Researcher Profiles - Matsuda Junya

写真a

Matsuda Junya

Affiliation

Nippon Medical School Hospital, Department of Cardiovascular Medicine, Assistant Professor

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Degree

医学博士 ( 日本医科大学 )

Research Areas

Life Science / Cardiology

Research History

日本医科大学付属病院循環器内科助教

2022.4

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日本医科大学付属病院心臓血管集中治療科助教

2018.9 - 2022.3

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日本医科大学付属病院循環器内科助教

2017.10 - 2018.8

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同愛記念病院循環器科

2014.9 - 2017.9

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日本医科大学付属病院心臓血管集中治療科助教

2014.7 - 2014.8

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日本医科大学成田国際空港クリニック

2014.4 - 2014.6

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日本医科大学武蔵小杉病院助教

2013.4 - 2014.3

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日本医科大学付属病院第一内科専修医

2011.4 - 2013.3

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Nippon Medical School

2009.4 - 2011.3

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Papers

Reply to letter to the editor: "Long-term clinical outcomes after alcohol septal ablation for hypertrophic obstructive cardiomyopathy in Japan: a retrospective study".

Junya Matsuda, Hitoshi Takano, Yoichi Imori, Kakeru Ishihara, Hideto Sangen, Yoshiaki Kubota, Jun Nakata, Hideki Miyachi, Yusuke Hosokawa, Shuhei Tara, Yukichi Tokita, Takeshi Yamamoto, Mitsunobu Kitamura, Morimasa Takayama, Kuniya Asai

Heart and vessels 2025.2

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We appreciate the comments from Arshad et al. regarding our study on long-term outcomes of alcohol septal ablation (ASA) for hypertrophic obstructive cardiomyopathy (HOCM) in Japan. Addressing concerns about sex-related differences, our analyses revealed no significant differences between men and women in overall mortality (log-rank P = 0.759) or major cardiovascular events (heart failure admission, P = 0.521; pacemaker/implantable cardioverter-defibrillator implantation, P = 0.234; sustained ventricular tachycardia/ventricular fibrillation, P = 0.615; new-onset atrial fibrillation, P = 0.894). The 12% reintervention rate is consistent with reported rates from high-volume centers over 10 years (10-15%), suggesting appropriate patient selection. Primary risk factors for reintervention were thicker interventricular septum and residual mitral regurgitation, as previously reported. Sustained efficacy of ASA is supported by 75% of patients maintaining NYHA class I at 10-year follow-up. These findings, while acknowledging potential differences between Japanese and Western populations, reinforce the long-term safety and effectiveness of ASA for HOCM in Japan.

DOI： 10.1007/s00380-025-02522-w

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Hospital Variability in the Use of Vasoactive Agents in Patients Hospitalized for Acute Decompensated Heart Failure for Clinical Phenotypes. International journal

Yasuyuki Shiraishi, Nozomi Niimi, Shun Kohsaka, Kazumasa Harada, Takashi Kohno, Makoto Takei, Takahiro Jimba, Hiroki Nakano, Junya Matsuda, Akito Shindo, Daisuke Kitano, Shigeto Tsukamoto, Shinji Koba, Takeshi Yamamoto, Morimasa Takayama

Circulation. Cardiovascular quality and outcomes e011270 2025.1

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BACKGROUND: The absence of practice standards in vasoactive agent usage for acute decompensated heart failure has resulted in significant treatment variability across hospitals, potentially affecting patient outcomes. This study aimed to assess temporal trends and institutional differences in vasodilator and inotrope/vasopressor utilization among patients with acute decompensated heart failure, considering their clinical phenotypes. METHODS: Data were extracted from a government-funded multicenter registry covering the Tokyo metropolitan area, comprising consecutive patients hospitalized in intensive/cardiovascular care units with a primary diagnosis of acute decompensated heart failure between January 2013 and December 2021. Clinical phenotypes, that is, pulmonary congestion or tissue hypoperfusion, were defined through a comprehensive assessment of clinical signs and symptoms, vital signs, and laboratory findings. We assessed the frequency and temporal trends in phenotype-based drug utilization of vasoactive agents and investigated institutional characteristics associated with adopting the phenotype-based approach using generalized linear mixed-effects models, with random intercepts to account for hospital-level variability. RESULTS: Among 37 293 patients (median age, 80 years; 43.7% female), 88.6% and 21.2% had pulmonary congestion and tissue hypoperfusion status, respectively. Throughout the study period, both overall and phenotype-based vasodilator utilizations showed significant declines, with overall usage dropping from 61.4% in 2013 to 48.6% in 2021 (Ptrend<0.001). Conversely, no temporal changes were observed in overall inotrope/vasopressor utilization from 24.6% in 2013 to 25.8% in 2021 or the proportion of phenotype-based utilization. Notably, there was considerable variability in phenotype-based drug utilization among hospitals, with a median ranging from 48.3% to 77.8%. In multivariable-adjusted models, a higher number of board-certified cardiologists were significantly associated with lower rates of phenotype-based vasodilator utilization and reduced inappropriate inotrope/vasopressor utilization, while tertiary care hospitals were linked to more appropriate inotrope/vasopressor utilization. CONCLUSIONS: Substantial variability existed among hospitals in phenotype-based drug utilization of vasoactive agents for patients with acute decompensated heart failure, highlighting the need for standardized treatment protocols. REGISTRATION: URL: https://www.umin.ac.jp/ctr/index.htm; Unique identifier: UMIN000013128.

DOI： 10.1161/CIRCOUTCOMES.124.011270

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Optimal ablation pattern on intraprocedural echocardiography is associated with favorable clinical outcomes of alcohol septal ablation for hypertrophic obstructive cardiomyopathy. International journal

Junya Matsuda, Yukichi Tokita, Lisa Hoshika, Kentaro Koyama, Kakeru Ishihara, Serina Kobayashi, Saori Uchiyama, Yoichi Imori, Yoshiaki Kubota, Jun Nakata, Hideki Miyachi, Shuhei Tara, Takeshi Yamamoto, Hitoshi Takano, Mitsunobu Kitamura, Morimasa Takayama, Kuniya Asai

Journal of cardiology 2025.1

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BACKGROUND: Alcohol septal ablation (ASA) is used to treat drug-refractory hypertrophic obstructive cardiomyopathy (HOCM). Intraprocedural echocardiography is essential for identifying the septal area perfused by each septal branch; however, its role in determining the procedural endpoint of ASA remains unclear. This retrospective study aimed to evaluate the impact of intraprocedural echocardiographic findings on clinical outcomes and left ventricular pressure gradient (LVPG) after ASA. METHODS: Overall, 120 patients with HOCM who underwent ASA at a single center were divided into two groups based on the presence of optimal ablation. Optimal ablation was defined as the ablated area fully covering the targeted septal myocardium from the point of contact with the onset of the accelerated flow to the basal septum and dense acoustic shadowing accompanying the ablated area. Clinical outcomes and LVPG changes were evaluated using inverse probability of treatment weighting. RESULTS: Significantly more patients showed a New York Heart Association (NYHA) functional class improvement of ≥2 stages or achievement of class I in the optimal ablation group (n = 74) than in the non-optimal ablation group (94 % vs. 62 %; p < 0.001). The optimal ablation group had a significantly greater percentage reduction in LVPG at 1-year after ASA (82 ± 18 % vs. 64 ± 18 %; p = 0.001). Multivariate analyses revealed that optimal ablation was an independent predictor of a NYHA functional class improvement of ≥2 stages or achievement of class I (odds ratio, 11.3; 95 % confidence interval, 3.43-39.1; p < 0.001) and a percentage reduction in LVPG (p = 0.001). CONCLUSIONS: Intraprocedural echocardiographic findings of optimal ablation were associated with favorable clinical outcomes and a significant reduction in LVPG.

DOI： 10.1016/j.jjcc.2025.01.007

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Long-term clinical outcomes after alcohol septal ablation for hypertrophic obstructive cardiomyopathy in Japan: a retrospective study.

Junya Matsuda, Hitoshi Takano, Yoichi Imori, Kakeru Ishihara, Hideto Sangen, Yoshiaki Kubota, Jun Nakata, Hideki Miyachi, Yusuke Hosokawa, Shuhei Tara, Yukichi Tokita, Takeshi Yamamoto, Mitsunobu Kitamura, Morimasa Takayama, Kuniya Asai

Heart and vessels 2024.11

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Hypertrophic cardiomyopathy is characterized by significant left ventricular wall thickening, often leading to obstructive symptoms. Alcohol septal ablation (ASA) has emerged as an effective treatment for patients with hypertrophic obstructive cardiomyopathy (HOCM) who remain symptomatic despite maximal medical therapy. However, the detailed long-term effects of ASA in Japanese patients with HOCM remain unclear. Therefore, this study aimed to investigate the long-term effects of ASA for HOCM by evaluating changes in symptoms, pressure gradient, hemodynamics, prognosis, and predictive factors for cardiovascular events over time. In this retrospective study, we examined 239 highly symptomatic patients (age, 64 ± 13 years; median follow-up, 6.9 years) treated with ASA for drug-refractory HOCM between 1998 and 2021. Patients were assessed using transthoracic echocardiography, magnetic resonance imaging, and cardiac catheterization. Follow-up evaluations included clinical assessments, electrocardiography, and echocardiography. Data analysis included descriptive statistics, Kaplan-Meier analysis, and multivariate regression. ASA reduced the left ventricular outflow tract gradient from 90.5 ± 52.8 to 14.4 ± 17.1 mmHg (P < 0.01) and New York Heart Association (NYHA) class from 3 [2.5-3] to 1 [1-2] at 10 years after ASA (P < 0.01). The 30-day mortality rate following ASA was 1%. Overall, 31 patients (13%) died during the follow-up period. The survival rates at 1, 5, 10, and 15 years after ASA were 97.4%, 89.9%, 83.7%, and 77.6%, respectively. Multivariable analysis revealed NYHA functional class before ASA (odds ratio [OR], 3.09; 95% confidence interval [CI], 1.40-6.82; P = 0.005), beta-blocker use (OR, 0.25; 95% CI, 0.07-0.91; P = 0.036), and class Ia agent use (OR, 0.31; 95% CI, 0.13-0.75; P = 0.009) as independent predictors of all-cause mortality. This study demonstrated low periprocedural and long-term mortality rates following ASA in patients with HOCM, suggesting that ASA provides durable symptomatic relief and reduces left ventricular outflow tract obstruction in selected highly symptomatic patients with HOCM.

DOI： 10.1007/s00380-024-02489-0

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Effects of Cardioprotective Drugs on 90-Day Mortality or Heart Transplantation in Patients With Fulminant Myocarditis.

Shuhei Tara, Takeshi Yamamoto, Koshiro Kanaoka, Eiichiro Oka, Reiko Shiomura, Junya Matsuda, Jun Nakata, Hideki Miyachi, Kenji Onoue, Yoshihiko Saito, Wataru Shimizu, Kuniya Asai

Circulation reports 6 ( 8 ) 322 - 332 2024.8

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BACKGROUND: Cardioprotective drugs have not been previously shown to improve the prognosis in patients with fulminant myocarditis presentation (FMP). We aimed to investigate whether cardioprotective drugs, including angiotensin-converting enzyme inhibitor (ACEI)/angiotensin II receptor blocker (ARB) and β-blocker, administered during hospitalization improved the prognosis in patients with FMP. METHODS AND RESULTS: This multicenter cohort study conducted in Japan included 755 patients with clinically diagnosed FMP. Those who died within 14 days of admission were excluded, and 588 patients (median age 53 [37-65] years and 40% female) were evaluated. The primary outcome was the composite of 90-day mortality or heart transplantation. The patients were divided into 4 groups according to whether they were administered ACEI/ARB or β-blocker during hospitalization. Administration of ACEI/ARB without β-blocker improved the overall patient outcomes (log-rank test [vs. ACEI/ARB - and β-blocker -]: ACEI/ARB + and β-blocker -, P<0.001; ACEI/ARB - and β-blocker +, P=0.256). Subsequently, a matched cohort of 146 patient pairs was generated for patients with or without ACEI/ARB administration during hospitalization. The outcome-free survival at 90 days was significantly higher in the ACEI/ARB administration group than in the non-administration group (hazard ratio 0.37; 95% confidence interval 0.19-0.71). CONCLUSIONS: Administration of ACEI or ARB during hospitalization was associated with favorable outcomes in terms of 90-day mortality and heart transplantation events in patients with clinically diagnosed FMP.

DOI： 10.1253/circrep.CR-24-0059

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Impact of polypharmacy on 3-year mortality in patients with heart failure: a retrospective study. International journal

Daisuke Hayashi, Yoshiaki Kubota, Takuya Nishino, Yukihiro Watanabe, Yoshiki Iwade, Junya Matsuda, Katsuhito Kato, Shuhei Tara, Yuya Ise, Yu-Ki Iwasaki, Kuniya Asai

Journal of pharmaceutical health care and sciences 10 ( 1 ) 34 - 34 2024.7

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BACKGROUND: Guideline-directed medical therapy (GDMT) is important in heart failure management; however, polypharmacy itself may impact heart failure. Although measures against polypharmacy are needed, current discussion on unilateral drug tapering (including the drugs that should be tapered) is insufficient. In this study, we investigated the relationship between the number of prescribed GDMT drugs and prognosis in patients with heart failure. METHODS: In this single-centre retrospective study, 3,146 eligible patients with heart failure were included and divided into four groups based on the median number of prescribed GDMT drugs and the median number of drugs not included in the GDMT (ni-GDMT) at the time of hospital discharge. The definition of GDMT was based on various Japanese guidelines. The primary outcome was all-cause mortality within 3 years of hospital discharge. RESULTS: A total of 252 deaths were observed during the 3-year follow-up period. Kaplan-Meier analysis revealed that groups with GDMT drug count ≥ 5 and ni-GDMT drug count < 4 had the lowest mortality, and those with GDMT drug count < 5 and ni-GDMT drug count ≥ 4 had the highest mortality (log-rank, P < 0.001). Cox regression analysis revealed a significant association between ni-GDMT drug count and all-cause mortality, even after adjustment for number of GDMT medications, age, male, left ventricular ejection function < 40%, hemoglobin, albumin levels, and estimated glomerular filtration rate [HR = 1.06 (95% CI: 1.01-1.11), P = 0.020]. Conversely, the GDMT drug count was not associated with increased mortality rates. CONCLUSIONS: The ni-GDMT drug count was significantly associated with 3-year mortality in patients with heart failure. Conversely, the GDMT drug count did not worsen the prognosis. Polypharmacy measures should consider ni-GDMT drug quantity to improve the prognosis and outcomes in patients with heart failure.

DOI： 10.1186/s40780-024-00357-7

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経皮的中隔心筋焼灼後の非持続性心室頻拍に対しカテーテルアブレーションが充功した閉塞性肥大型心筋症の1例

中村広一, 松田淳也, 高橋應仁, 小山賢太郎, 渡邉将央, 石原翔, 木村徳宏, 塩村玲子, 澁谷淳介, 野間さつき, 久保田芳明, 林洋史, 井守洋一, 中田淳, 宮地秀樹, 太良修平, 時田祐吉, 岩崎雄樹, 山本剛, 浅井邦也

日本心血管インターベンション治療学会抄録集 32回 MP44 - 3 2024.7

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川崎病冠動脈病変を合併した成人安定冠動脈疾患に対し経皮的冠動脈インターベンションを施行した3症例

瀬崎あやの, 時田祐吉, 中村広一, 浅見慎思, 高橋慶仁, 小山賢太郎, 渡邉将央, 石原翔, 木村徳宏, 澁谷淳介, 塩村玲子, 松田淳也, 野間さつき, 久保田芳明, 中田淳, 宮地秀樹, 太良修平, 山本剛, 浅井邦也

日本心血管インターベンション治療学会抄録集 32回 MI6 - 5 2024.7

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Comparison of clinical characteristics and prognostic factors in patients with heart failure with preserved ejection fraction with and without renal dysfunction. International journal

Kenichi Matsushita, Kazumasa Harada, Takashi Kohno, Hiroki Nakano, Daisuke Kitano, Junya Matsuda, Hideaki Yoshino, Takeshi Yamamoto, Ken Nagao, Morimasa Takayama

Minerva cardiology and angiology 2024.5

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BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) with renal dysfunction (RD) is considered to be a specific phenotype of HFpEF. This study aimed to compare the clinical characteristics and prognostic factors for in-hospital mortality between HFpEF-diagnosed patients with and without RD. METHODS: This multicenter retrospective study included 5867 consecutive patients with acute HFpEF. RD was defined by an estimated glomerular filtration rate (eGFR) of <60 mL/min per 1.73 m2. Kaplan-Meier survival curves and log-rank tests were used to compare the in-hospital mortality between the groups. Univariable and multivariable Cox regression analyses were performed to identify significant prognostic factors. RESULTS: Across the study cohort, 68% of patients had RD. In-hospital mortality was significantly higher in HFpEF patients with RD than in those without RD. The comorbidities and laboratory data differed significantly between the groups. Independent prognostic factors for in-hospital mortality in the HFpEF patients with RD were age (hazard ratio [HR], 1.039), systolic blood pressure (HR, 0.991), eGFR (HR, 0.981), C-reactive protein (CRP; HR, 1.028), diuretics (HR, 0.374), angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers (ACE-I/ARBs; HR, 0.680), and beta-blockers (HR, 0.662). In HFpEF patients without RD, age (HR, 1.039), systolic blood pressure (HR, 0.979), and ACE-I/ARBs (HR, 0.373) were independent prognostic factors. CONCLUSIONS: Significant differences in the clinical characteristics and prognostic factors, such as CRP and beta-blockers, were observed between the HFpEF patients with and without RD. These results have implications for future research and may help guide individualized patient management strategies.

DOI： 10.23736/S2724-5683.24.06510-4

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Prevalence and clinical characteristics of diabetic cardiomyopathy in patients with acute heart failure. International journal

Kenichi Matsushita, Kazumasa Harada, Takashi Kohno, Hiroki Nakano, Daisuke Kitano, Junya Matsuda, Makoto Takei, Hideaki Yoshino, Takeshi Yamamoto, Ken Nagao, Morimasa Takayama

Nutrition, metabolism, and cardiovascular diseases : NMCD 34 ( 5 ) 1325 - 1333 2024.5

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BACKGROUND AND AIMS: Diabetic cardiomyopathy refers to cases of diabetes mellitus (DM) complicated by cardiac dysfunction in the absence of cardiovascular disease and hypertension. Its epidemiology remains unclear due to the high rate of coexistence between DM and hypertension. Therefore, this study aimed to examine the prevalence and clinical characteristics of diabetic cardiomyopathy among patients with acute heart failure (HF). METHODS AND RESULTS: This multicenter, retrospective study included 17,614 consecutive patients with acute HF. DM-related HF was defined as HF complicating DM without known manifestations of coronary artery disease, significant valvular heart disease, or congenital heart disease, while diabetic cardiomyopathy was defined as DM-related HF without hypertension. Univariable and multivariable logistic regression analyses were performed to identify factors associated with in-hospital mortality. Diabetic cardiomyopathy prevalence was 1.6 % in the entire cohort, 5.2 % in patients with acute HF complicating DM, and 10 % in patients with DM-related HF. Clinical characteristics, including the presence of comorbidities, laboratory data on admission, and factors associated with in-hospital mortality, significantly differed between the diabetic cardiomyopathy group and the DM-related HF with hypertension group. The in-hospital mortality rate was significantly higher in patients with diabetic cardiomyopathy than in patients with DM-related HF with hypertension (7.7 % vs. 2.8 %, respectively; P < 0.001). CONCLUSION: The prevalence of diabetic cardiomyopathy was 1.6 % in patients with acute HF, and patients with diabetic cardiomyopathy were at high risk for in-hospital mortality. The clinical characteristics of patients with diabetic cardiomyopathy were significantly different than those of patients with DM-related HF with hypertension.

DOI： 10.1016/j.numecd.2023.12.013

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Fractional excretion of urea nitrogen can identify true worsening renal function in patients with heart failure International journal

Yukihiro Watanabe, Yoshiaki Kubota, Takuya Nishino, Shuhei Tara, Katsuhito Kato, Daisuke Hayashi, Junya Matsuda, Hideki Miyachi, Yukichi Tokita, Yu‐ki Iwasaki, Kuniya Asai

ESC Heart Failure 2024.3

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Language：English Publishing type：Research paper (scientific journal) Publisher：Wiley

Abstract

Aims

Fractional excretion of urea nitrogen (FEUN), used to differentiate the cause of acute kidney injury, has emerged as a useful fluid index in patients with heart failure (HF). We hypothesized that FEUN could be useful in identifying worsening renal function (WRF) associated with poor outcomes in patients with acute HF (AHF).

Methods and results

Overall, 1103 patients with AHF (median age, 78 years; male proportion, 60%) were categorized into six groups according to the presence of WRF and FEUN values (low, ≤32.1%; medium, >32.1% and ≤38.0%; and high, >38.0%) at discharge. WRF was defined as an increase of ≥0.3 mg/dL in the serum creatinine level from admission to discharge. FEUN was calculated by the following formula: (urinary urea × serum creatinine) × 100/(serum urea × urinary creatinine). The cut‐off values for low, medium, and high FEUN were based on a previous study. The primary outcome of this study was HF readmission after hospital discharge. During the 1 year follow‐up, 170 HF readmissions occurred. Kaplan–Meier analysis revealed significantly higher HF readmission rates in patients with WRF than in those without WRF (log‐rank test, P < 0.001). Additionally, among patients with WRF, HF readmission rates were lowest in those with medium FEUN values, followed by those with low FEUN values and those with high FEUN values. On multivariable analysis, the presence of WRF with low or high FEUN values was independently associated with increased HF readmission, as compared with the absence of WRF with medium FEUN values. Notably, no association was noted between WRF with medium FEUN values and HF readmission.

Conclusions

The prognostic impact of WRF was significantly mediated by the FEUN values and was associated with worse outcomes only when the FEUN values were either low or high. Our study suggests that FEUN can identify prognostically relevant WRF in patients with AHF.

DOI： 10.1002/ehf2.14755

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認知症高齢者の日常生活自立度と退院時看護必要度B項目が慢性心不全患者の予後に与える影響

完山穂波, 久保田芳明, 大金美羽子, 背戸陽子, 西野拓也, 林太祐, 岩出佳樹, 加藤活人, 渡邉将央, 松田淳也, 宮地秀樹, 太良修平, 時田祐吉, 岩崎雄樹, 浅井邦也

日本循環器学会学術集会抄録集 88回 CO3 - 7 2024.3

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ミネラルコルチコイド受容体拮抗薬を中止した慢性心不全患者の臨床背景と転帰

岩出佳樹, 久保田芳明, 林太祐, 西野拓也, 完山穂波, 渡邉将央, 松田淳也, 加藤活人, 太良修平, 宮地秀樹, 時田祐吉, 伊勢雄也, 岩崎雄樹, 浅井邦也

日本循環器学会学術集会抄録集 88回 CO3 - 6 2024.3

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心不全患者における不眠症治療薬使用の実態経年的変化を踏まえた検討

林太祐, 久保田芳明, 西野拓也, 岩出佳樹, 完山穂波, 渡邉将央, 松田淳也, 加藤活人, 太良修平, 宮地秀樹, 時田祐吉, 伊勢雄也, 岩崎雄樹, 浅井邦也

日本循環器学会学術集会抄録集 88回 CO1 - 6 2024.3

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The Impact of Change of SYNTAX Score and SYNTAX Score II on the Long-Term Prognosis after Percutaneous Coronary Intervention(タイトル和訳中)

小野有希, 時田祐吉, 石原翔, 渡邉将央, 木村徳宏, 澁谷淳介, 塩村玲子, 松田淳也, 野間さつき, 久保田芳明, 中田淳, 宮地秀樹, 太良修平, 山本剛, 浅井邦也

日本循環器学会学術集会抄録集 88回 OJ19 - 3 2024.3

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Eosinophilic Granulomatosis with Polyangiitis-Induced Eosinophilic Endomyocarditis with marked endocardial thickening and "Sea Urchin Roe-Like" Endocardial Thrombus. International journal

Junya Matsuda, Takeshi Yamamoto, Yousuke Ishii, Kuniya Asai

European heart journal. Cardiovascular Imaging 25 ( 6 ) e166 2024.1

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DOI： 10.1093/ehjci/jeae004

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Favorable Long-Term Outcomes After Alcohol Septal Ablation for Hypertrophic Obstructive Cardiomyopathy in Japan.

Yukichi Tokita, Junya Matsuda, Yoichi Imori

Circulation journal : official journal of the Japanese Circulation Society 88 ( 1 ) 133 - 134 2023.12

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DOI： 10.1253/circj.CJ-23-0846

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Forecasting the Acute Heart Failure Admissions: Development of Deep Learning Prediction Model Incorporating the Climate Information International journal

Takahiro Jimba, Satoshi Kodera, Shun Kohsaka, Toshiaki Otsuka, Kazumasa Harada, Akito Shindo, Yasuyuki Shiraishi, Takashi Kohno, Makoto Takei, Hiroki Nakano, Junya Matsuda, Takeshi Yamamoto, Ken Nagao, Morimasa Takayama

Journal of Cardiac Failure 30 ( 2 ) 404 - 409 2023.11

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BACKGROUND: Climate is known to influence the incidence of cardiovascular events. However, their prediction with traditional statistical models remains imprecise. METHODS AND RESULTS: We analyzed 27,799 acute heart failure (AHF) admissions within the Tokyo CCU Network Database from January 2014 to December 2019. High-risk AHF (HR-AHF) day was defined as a day with the upper 10th percentile of AHF admission volume. Deep neural network (DNN) and traditional regression models were developed using the admissions in 2014-2018 and tested in 2019. Explanatory variables included 17 meteorological parameters. Shapley additive explanations were used to evaluate their importance. The median number of incidences of AHF was 12 (9-16) per day in 2014-2018 and 11 (9-15) per day in 2019. The predicted AHF admissions correlated well with the observed numbers (DNN: R2 = 0.413, linear regression: R2 = 0.387). The DNN model was superior in predicting HR-AHF days compared with the logistic regression model [c-statistics: 0.888 (95% CI: 0.818-0.958) vs 0.827 (95% CI: 0.745-0.910): P = .0013]. Notably, the strongest predictive variable was the 7-day moving average of the lowest ambient temperatures. CONCLUSIONS: The DNN model had good prediction ability for incident AHF using climate information. Forecasting AHF admissions could be useful for the effective management of AHF.

DOI： 10.1016/j.cardfail.2023.10.476

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Percutaneous transluminal septal myocardial ablation for right ventricular outflow tract obstruction with repaired tetralogy of Fallot. International journal

Junya Matsuda, Yoichi Imori, Yukichi Tokita, Hitoshi Takano, Kuniya Asai

European heart journal. Cardiovascular Imaging 24 ( 10 ) e284 2023.9

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DOI： 10.1093/ehjci/jead167

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Predictive Factors for Decreasing Left Ventricular Ejection Fraction and Progression to the Dilated Phase of Hypertrophic Cardiomyopathy. International journal

Kakeru Ishihara, Yoshiaki Kubota, Junya Matsuda, Yoichi Imori, Yukichi Tokita, Kuniya Asai, Hitoshi Takano

Journal of clinical medicine 12 ( 15 ) 2023.8

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Patients with hypertrophic cardiomyopathy (HCM) may progress to the dilated phase (DHCM). This study aimed to identify the predictive factors for DHCM progression, including left ventricular (LV) ejection fraction (LVEF < 50%) or decreased LV contraction (LVEF < 60%). The study included 291 patients enrolled in our hospital's HCM registry who were grouped based on their poststudy LVEF (LVEF of ≥60%, 50-59%, and <50%). Predictive factors of an LVEF of <50% or <60% were determined. Further, the effects of percutaneous transluminal septal myocardial ablation (PTSMA) on long-term systolic LV function and DHCM development were investigated. LVEF was ≥60%, 50-59%, and <50% in 239, 33, and 19 patients, respectively, during the follow-up period (mean: 64.9 months). Multivariate analyses indicated baseline atrial fibrillation (AF), nonsustained ventricular tachycardia (NSVT), and left ventricular diameter at end-systole (LVDs) as significant predictors of DHCM. Using a scoring method based on AF, NSVT, and LVDs, patients with 2 and 3 points had a significantly higher risk of developing DHCM. PTSMA in 78 HCM patients demonstrated no significant effect on long-term LVEF changes or DHCM development. We concluded that AF, NSVT, and LVDs are significant predictors of DHCM development. However, a validation study with a larger population is required.

DOI： 10.3390/jcm12155137

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個々の血栓症リスク因子が高出血リスク患者に留置されたステントの血管内視鏡所見に与える影響

橘貴大, 時田祐吉, 中島悠希, 渡邉将央, 福山曜, 石原翔, 茂澤幸右, 澁谷淳介, 塩村玲子, 松田淳也, 野間さつき, 久保田芳明, 中田淳, 宮地秀樹, 太良脩平, 山本剛, 高野仁司, 浅井邦也

日本心血管インターベンション治療学会抄録集 31回 MP85 - 7 2023.8

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Utility of fractional excretion of urea nitrogen in heart failure patients with chronic kidney disease. International journal

Yukihiro Watanabe, Yoshiaki Kubota, Takuya Nishino, Shuhei Tara, Katsuhito Kato, Daisuke Hayashi, Kosuke Mozawa, Junya Matsuda, Yukichi Tokita, Masahiro Yasutake, Kuniya Asai, Yu-Ki Iwasaki

ESC heart failure 10 ( 3 ) 1706 - 1716 2023.2

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AIMS: Maintenance of euvolaemia with diuretics is critical in heart failure (HF) patients with chronic kidney disease (CKD); however, it is challenging because no reliable marker of volume status exists. Fractional excretion of urea nitrogen (FEUN) is a useful index of volume status in patients with renal failure. We aimed to examine whether FEUN is a surrogate marker of volume status for risk stratification in HF patients with CKD. METHODS AND RESULTS: We examined 516 HF patients with CKD (defined as discharge estimated glomerular filtration rate < 60 mL/min/1.73 m2 ) whose FEUN was measured at discharge (median age, 80 years; 58% male). The patients were divided into four groups according to quartile FEUN value at discharge: low-FEUN, FEUN ≤ 32.1; medium-FEUN, 32.1 < FEUN ≤ 38.0; high-FEUN, 38.0 < FEUN ≤ 43.7; and extremely-high-FEUN, FEUN > 43.7. FEUN was calculated by the following formula: (urinary urea × serum creatinine) × 100/(serum urea × urinary creatinine). During the 3 year follow-up, 131 HF readmissions occurred. Kaplan-Meier analysis showed that the HF readmission rate was significantly lower in the medium-FEUN group than in the other three groups (log-rank test, P = 0.029). Multivariate Cox regression analysis identified the low-FEUN, high-FEUN, and extremely-high-FEUN values as independent factors associated with post-discharge HF readmission. In the analysis of 130 patients who underwent right heart catheterization during hospitalization, a significant correlation between FEUN value and right atrial pressure was observed (R = 0.243, P = 0.005). Multivariate linear regression analysis revealed that FEUN value at discharge decreased in a dose-dependent manner with loop diuretics. CONCLUSIONS: In HF patients with CKD, FEUN is a potential marker of volume status for risk stratification of post-discharge HF readmission. Low FEUN value (FEUN ≤ 32.1) may represent intravascular dehydration, whereas high FEUN value (FEUN > 38.0) may represent residual congestion; both of them were independent risk factors for HF readmission. FEUN may be useful to determine euvolaemia and guide fluid management in HF patients with CKD.

DOI： 10.1002/ehf2.14327

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Clinical Characteristics and Prognosis of Life-Threatening Acute Myocardial Infarction in Patients Transferred to an Emergency Medical Care Center.

Hideto Sangen, Takeshi Yamamoto, Shuhei Tara, Tokuhiro Kimura, Noritomo Narita, Kenta Onodera, Keishi Suzuki, Junya Matsuda, Kosuke Kadooka, Kenta Takahashi, Toshinori Ko, Hiroshi Hayashi, Jun Nakata, Yusuke Hosokawa, Koichi Akutsu, Hitoshi Takano, Tomohiko Masuno, Shoji Yokobori, Hiroyuki Yokota, Wataru Shimizu, Kuniya Asai

International heart journal 64 ( 2 ) 164 - 171 2023

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Patients with acute myocardial infarction (AMI) triaged as life-threatening are transferred to our emergency medical care center (EMCC). However, data on these patients remain limited. We aimed to compare the characteristics and AMI prognosis of patients transferred to our EMCC with those transferred to our cardiovascular intensive care unit (CICU) using whole and propensity-matched cohorts.We analyzed the data of 256 consecutive AMI patients transferred from the scene to our hospital by ambulance between 2014 and 2017. The EMCC and CICU groups comprised 77 and 179 patients, respectively. There were no significant between-group age or sex differences. Patients in the EMCC group had more disease severity score and had the left main trunk identified as the culprit more frequently (12% versus 0.6%, P < 0.001) than those in the CICU group; however, the number of patients with multiple culprit vessels did not differ. The EMCC group had a longer door-to-reperfusion time (75 [60, 109] minutes versus 60 [40, 86] minutes, P< 0.001) and a higher in-hospital mortality (19% versus 4.5%, P < 0.001), especially from non-cardiac causes (10% versus 0.6%, P < 0.001), than the CICU group. However, peak myocardial creatine phosphokinase did not significantly differ between the groups. The EMCC group had a significantly higher 1-year post-discharge mortality than the CICU group (log-rank, P = 0.032); this trend was maintained after propensity score matching, although the difference was not statistically significant (log-rank, P = 0.094).AMI patients transferred to the EMCC exhibited more severe disease and worse overall in-hospital and non-cardiac mortality than those transferred to the CICU.

DOI： 10.1536/ihj.22-654

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Comparison of Percutaneous Coronary Intervention Procedures and Outcomes for Recent and Acute ST-Elevation Myocardial Infarction.

Yusuke Hosokawa, Takeshi Yamamoto, Shuhei Tara, Noritomo Narita, Kenta Onodera, Keishi Suzuki, Junya Matsuda, Kosuke Kadooka, Toshinori Ko, Hideto Sangen, Mitsunobu Kitamura, Jun Nakata, Hideki Miyachi, Yukichi Tokita, Koichi Akutsu, Hitoshi Takano, Wataru Shimizu, Kuniya Asai

International heart journal 64 ( 3 ) 352 - 357 2023

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Although the primary percutaneous coronary intervention (PCI) is an established treatment for acute ST-elevation myocardial infarction (STEMI), relevant guidelines do not recommend it for recent-STEMI cases with a totally occluded infarcted related artery (IRA). However, PCI is allowed in Japan for recent-STEMI cases, but little is known regarding its outcomes. We aimed to examine the details and outcomes of PCI procedures in recent-STEMI cases with a totally occluded IRA and compared the findings with those in acute-STEMI cases.Among the 903 consecutive patients admitted with acute coronary syndrome, 250 were treated with PCI for type I STEMI with a totally occluded IRA. According to the time between symptom onset and diagnosis, patients were divided into the recent-STEMI (n = 32) and acute-STEMI (n = 218) groups. The background, procedure details, and short-term outcomes were analyzed. No significant differences between the groups were noted regarding patient demographics, acute myocardial infarction severity, or IRA distribution. Although the stent number and type were similar, significant differences were observed among PCI procedures, including the number of guidewires used, rate of microcatheter or double-lumen catheter use, and application rate of thrombus aspiration. The thrombolysis rate in the myocardial infarction flow 3-grade post-PCI did not differ significantly between the groups. Both groups had a low frequency of procedure-related complications. The in-hospital mortality rates were 0% and 4.6% in the recent-STEMI and acute-STEMI groups, respectively (P > 0.05).Although recent-STEMI cases required complicated PCI techniques, their safety, success rate, and in-hospital mortality were comparable to those of acute-STEMI cases.

DOI： 10.1536/ihj.22-656

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Measurement of Turbulent Kinetic Energy in Hypertrophic Cardiomyopathy Using Triple-velocity Encoding 4D Flow MR Imaging.

Kotomi Iwata, Tetsuro Sekine, Junya Matsuda, Masaki Tachi, Yoichi Imori, Yasuo Amano, Takahiro Ando, Makoto Obara, Gerard Crelier, Masashi Ogawa, Hitoshi Takano, Shinichiro Kumita

Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine 23 ( 1 ) 39 - 48 2022.12

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PURPOSE: The turbulent kinetic energy (TKE) estimation based on 4D flow MRI has been currently developed and can be used to estimate the pressure gradient. The objective of this study was to validate the clinical value of 4D flow-based TKE measurement in patients with hypertrophic cardiomyopathy (HCM). METHODS: From April 2018 to March 2019, we recruited 28 patients with HCM. Based on echocardiography, they were divided into obstructed HCM (HOCM) and non-obstructed HCM (HNCM). Triple-velocity encoding 4D flow MRI was performed. The volume-of-interest from the left ventricle to the aortic arch was drawn semi-automatically. We defined peak turbulent kinetic energy (TKEpeak) as the highest TKE phase in all cardiac phases. RESULTS: TKEpeak was significantly higher in HOCM than in HNCM (14.83 ± 3.91 vs. 7.11 ± 3.60 mJ, P < 0.001). TKEpeak was significantly higher in patients with systolic anterior movement (SAM) than in those without SAM (15.60 ± 3.96 vs. 7.44 ± 3.29 mJ, P < 0.001). Left ventricular (LV) mass increased proportionally with TKEpeak (P = 0.012, r = 0.466). When only the asymptomatic patients were extracted, a stronger correlation was observed (P = 0.001, r = 0.842). CONCLUSION: TKE measurement based on 4D flow MRI can detect the flow alteration induced by systolic flow jet and LV outflow tract geometry, such as SAM in patients with HOCM. The elevated TKE is correlated with increasing LV mass. This indicates that increasing cardiac load, by pressure loss due to turbulence, induces progression of LV hypertrophy, which leads to a worse prognosis.

DOI： 10.2463/mrms.mp.2022-0051

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External Validation of the Kumamoto Criteria in Transthyretin Amyloid Cardiomyopathy Screening - A Retrospective Cohort Study.

Yukihiro Watanabe, Hiroshige Murata, Hitoshi Takano, Tomonari Kiriyama, Shinobu Kunugi, Masato Hachisuka, Saori Uchiyama, Junya Matsuda, Hiroyuki Nakano, Yoichi Imori, Kenji Yodogawa, Yu-Ki Iwasaki, Eitaro Kodani, Akira Shimizu, Wataru Shimizu

Circulation reports 4 ( 12 ) 579 - 587 2022.12

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Background: The Kumamoto criteria have been proposed as a non-invasive screen for transthyretin amyloid cardiomyopathy. This study assessed the validity of the Kumamoto criteria externally. Methods and Results: The study included 138 patients (median age 73 years; 65% male) who underwent 99 mTc-pyrophosphate (PYP) scintigraphy. Patients were divided into 4 groups according to total scores on the Kumamoto criteria (i.e., 0-3) for the following 3 factors: high-sensitivity cardiac troponin T ≥0.0308 ng/mL, wide (≥120 ms) QRS, and left ventricular posterior wall thickness ≥13.6 mm. The diagnostic performance and positive predictive value (PPV) of the Kumamoto criteria for positive 99 mTc-PYP scintigraphy were validated. Eighteen (13%) patients were positive on 99 mTc-PYP scintigraphy. The Kumamoto criteria had a favorable diagnostic performance (area under the curve 0.808). The PPV for groups with scores of 0, 1, 2, and 3 was 0% (n=0/42), 11% (n=6/57), 21% (n=7/33), and 83% (n=5/6), respectively, which is lower, particularly for those with a score of 2, than in the original Kumamoto cohort. However, the PPV increased after combining the Kumamoto criteria with a history of orthopedic diseases (spinal canal stenosis and/or carpal tunnel syndrome). Conclusions: This study suggests that the Kumamoto criteria have a favorable diagnostic performance; however, the PPV may decrease depending on the study population. Combining the Kumamoto criteria with the presence of orthopedic disease may improve the PPV.

DOI： 10.1253/circrep.CR-22-0110

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Angioscopic findings 1 year after percutaneous coronary intervention for chronic total occlusion. Reviewed International journal

Isamu Fukuizumi, Yukichi Tokita, Reiko Shiomura, Satsuki Noma, Junya Matsuda, Hideto Sangen, Yoshiaki Kubota, Hidenori Komiyama, Jun Nakata, Hideki Miyachi, Shuhei Tara, Wataru Shimizu, Takeshi Yamamoto, Hitoshi Takano

Journal of cardiology 81 ( 1 ) 91 - 96 2022.8

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BACKGROUND: Chronic total occlusion (CTO) is a high-risk factor for stent thrombosis, but little is known about the difference in neointimal healing between CTO and non-CTO lesions regarding implanted stents. We investigated factors affecting neointimal healing after stent implantation for CTO and non-CTO lesions using angioscopy. METHODS: We retrospectively evaluated 106 stents in 85 consecutive patients between March 2016 and July 2020. Their average age was 68 ± 11 years, and participants (73 male and 12 female) underwent follow-up angiography and angioscopy 1 year after percutaneous coronary intervention (PCI). The stents (n = 106) were divided into three groups according to the lesion status at the previous PCI: CTO (n = 17), acute coronary syndrome (ACS) (n = 35), and stable coronary artery disease without CTO or non-CTO (n = 54). RESULTS: The neointimal stent coverage grade was significantly lower in the CTO and ACS groups than in the non-CTO group (0.4 ± 0.5, 0.9 ± 0.8, and 1.4 ± 0.8, respectively, p < 0.001). Thrombi were significantly more frequent in CTO and ACS than in non-CTO (71 %, 51 %, and 15 %, respectively, p < 0.001). The yellow grade in CTO was comparable to that in ACS but significantly higher in CTO than in non-CTO (CTO vs. ACS vs. non-CTO 1.5 ± 0.7, 1.4 ± 0.6, and 0.9 ± 0.7, respectively, p = 0.007). CONCLUSIONS: Delayed healing occurs in stents implanted for CTO lesions. Longer dual-antithrombotic therapy may be beneficial.

DOI： 10.1016/j.jjcc.2022.08.008

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閉塞性肥大型心筋症に対する中隔縮小療法～PTSMAと中隔心筋切除術カテーテル治療、外科手術、最適な選択は? 薬剤抵抗性閉塞性肥大型心筋症に対する経皮的中隔心筋焼灼術

高野仁司, 井守洋一, 松田淳也, 諸岡雅城, 石原翔, 小山賢太郎, 時田祐吉

日本心血管インターベンション治療学会抄録集 30回 [S15 - 1] 2022.7

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Clinical features and long-term prognosis of patients with congestive heart failure taking tolvaptan: a comparison of patients with preserved and reduced left ventricular ejection fraction. Reviewed

Toshiki Seki, Yoshiaki Kubota, Junya Matsuda, Yukichi Tokita, Yu-Ki Iwasaki, Wataru Shimizu

Heart and vessels 37 ( 4 ) 574 - 582 2022.4

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Few studies have investigated the clinical benefit of the long-term use of tolvaptan (TLV) for heart failure (HF). This study evaluated the long-term prognosis of patients administered TLV for > 1 year among patients who had HF with preserved ejection fraction (HFpEF) and those who had HF with reduced ejection fraction (HFrEF). Overall, 591 consecutive patients were admitted to our hospital and administered TLV for HF between 2011 and 2018. We retrospectively enrolled 147 patients who were administered TLV for > 1 year. We divided them into the HFpEF group (n = 77, 52.4%) and the HFrEF group (n = 70; 47.6%). Their clinical backgrounds and long-term prognosis were examined. Compared with the patients in the HFrEF group, the patients in the HFpEF group were significantly older and included more women. Moreover, the HFpEF group showed significantly lower all-cause mortality (38.6% vs. 24.7%; log-rank, P = 0.014) and cardiovascular mortality during the average 2.7-year follow-up. Univariate analysis revealed that all-cause mortality was correlated with male sex, HFpEF, and changes in serum creatinine levels from baseline. Multivariate analysis revealed that HFpEF was an independent influencing factor for all-cause mortality (hazard ratio, 0.44; 95% confidence interval, 0.23-0.86; P = 0.017). Long-term administration of TLV may be more beneficial for HFpEF than for HFrEF.

DOI： 10.1007/s00380-021-01957-1

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Hemodynamic Parameters for Cardiovascular System in 4D Flow MRI: Mathematical Definition and Clinical Applications. Reviewed

Keiichi Itatani, Tetsuro Sekine, Masaaki Yamagishi, Yoshinobu Maeda, Norika Higashitani, Shohei Miyazaki, Junya Matsuda, Yasuo Takehara

Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine 21 ( 2 ) 380 - 399 2022.3

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Blood flow imaging becomes an emerging trend in cardiology with the recent progress in computer technology. It not only visualizes colorful flow velocity streamlines but also quantifies the mechanical stress on cardiovascular structures; thus, it can provide the detailed inspections of the pathophysiology of diseases and predict the prognosis of cardiovascular functions. Clinical applications include the comprehensive assessment of hemodynamics and cardiac functions in echocardiography vector flow mapping (VFM), 4D flow MRI, and surgical planning as a simulation medicine in computational fluid dynamics (CFD).For evaluation of the hemodynamics, novel mathematically derived parameters obtained using measured velocity distributions are essential. Among them, the traditional and typical parameters are wall shear stress (WSS) and its related parameters. These parameters indicate the mechanical damages to endothelial cells, resulting in degenerative intimal change in vascular diseases. Apart from WSS, there are abundant parameters that describe the strength of the vortical and/or helical flow patterns. For instance, vorticity, enstrophy, and circulation indicate the rotating flow strength or power of 2D vortical flows. In addition, helicity, which is defined as the cross-linking number of the vortex filaments, indicates the 3D helical flow strength and adequately describes the turbulent flow in the aortic root in cases with complicated anatomies. For the description of turbulence caused by the diseased flow, there exist two types of parameters based on completely different concepts, namely: energy loss (EL) and turbulent kinetic energy (TKE). EL is the dissipated energy with blood viscosity and evaluates the cardiac workload related to the prognosis of heart failure. TKE describes the fluctuation in kinetic energy during turbulence, which describes the severity of the diseases that cause jet flow. These parameters are based on intuitive and clear physiological concepts, and are suitable for in vivo flow measurements using inner velocity profiles.

DOI： 10.2463/mrms.rev.2021-0097

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Adjunctive Catheter-Directed Thrombolysis during Primary PCI for ST-Segment Elevation Myocardial Infarction with High Thrombus Burden. Reviewed International journal

Satsuki Noma, Hideki Miyachi, Isamu Fukuizumi, Junya Matsuda, Hideto Sangen, Yoshiaki Kubota, Yoichi Imori, Yoshiyuki Saiki, Yusuke Hosokawa, Shuhei Tara, Yukichi Tokita, Koichi Akutsu, Wataru Shimizu, Takeshi Yamamoto, Hitoshi Takano

Journal of clinical medicine 11 ( 1 ) 2022.1

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BACKGROUND: High coronary thrombus burden has been associated with unfavorable outcomes in patients with ST-segment elevation myocardial infarction (STEMI), the optimal management of which has not yet been established. METHODS: We assessed the adjunctive catheter-directed thrombolysis (CDT) during primary percutaneous coronary intervention (PCI) in patients with STEMI and high thrombus burden. CDT was defined as intracoronary infusion of tissue plasminogen activator (t-PA; monteplase). RESULTS: Among the 1849 consecutive patients with STEMI, 263 had high thrombus burden. Moreover, 41 patients received t-PA (CDT group), whereas 222 did not receive it (non-CDT group). No significant differences in bleeding complications and in-hospital and long-term mortalities were observed (9.8% vs. 7.2%, p = 0.53; 7.3% vs. 2.3%, p = 0.11; and 12.6% vs. 17.5%, p = 0.84, CDT vs. non-CDT). In patients who underwent antecedent aspiration thrombectomy during PCI (75.6% CDT group and 87.4% non-CDT group), thrombolysis in myocardial infarction grade 2 or 3 flow rate after thrombectomy was significantly lower in the CDT group than in the non-CDT group (32.2% vs. 61.0%, p < 0.01). However, the final rates improved without significant difference (90.3% vs. 97.4%, p = 0.14). CONCLUSIONS: Adjunctive CDT appears to be tolerated and feasible for high thrombus burden. Particularly, it may be an option in cases with failed aspiration thrombectomy.

DOI： 10.3390/jcm11010262

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Impact of the COVID-19 Pandemic on ST-elevation Myocardial Infarction from a Single-center Experience in Tokyo Reviewed

Yukihiro Watanabe, Hideki Miyachi, Kosuke Mozawa, Kenta Yamada, Eiichiro Oka, Reiko Shiomura, Yoichiro Sugizaki, Junya Matsuda, Jun Nakata, Shuhei Tara, Yukichi Tokita, Yu-ki Iwasaki, Takeshi Yamamoto, Hitoshi Takano, Wataru Shimizu

Internal Medicine 60 ( 23 ) 3693 - 3700 2022

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Objective The coronavirus disease 2019 (COVID-19) pandemic has had a significant impact on global healthcare systems. Some studies have reported the negative impact of COVID-19 on ST-elevation myocardial infarction (STEMI) patients; however, the impact in Japan remains unclear. This study investigated the impact of the COVID-19 pandemic on STEMI patients admitted to an academic tertiary-care center in Tokyo, Japan. Methods In this retrospective, observational, cohort study, we included 398 consecutive patients who were admitted to our institute from January 1, 2018, to March 10, 2021, and compared the incidence of hospitalization, clinical characteristics, time course, management, and outcomes before and after March 11, 2020, the date when the World Health Organization declared COVID-19 a pandemic. Results There was a 10.7% reduction in hospitalization of STEMI patients during the COVID-19 pandemic compared with that in the previous year (117 vs. 131 cases). During the COVID-19 pandemic, the incidence of late presentation was significantly higher (26.5% vs. 12.1%, p<0.001), and the onset-to-door [241 (IQR: 70-926) vs. 128 (IQR: 66-493) minutes, p=0.028] and door-to-balloon [72 (IQR: 61-128) vs. 60 (IQR: 43-90) min, p<0.001] times were significantly longer than in the previous year. Furthermore, the in-hospital mortality was higher, but the difference was not significant (9.4% vs. 5.0%, p=0.098). Conclusion The COVID-19 pandemic significantly impacted STEMI patients in Tokyo and resulted in a slight decrease in hospitalization, a significant increase in late presentation and treatment delays, and a slight but nonsignificant increase in mortality. In the COVID-19 era, the acute management system for STEMI in Japan must be reviewed.

DOI： 10.2169/internalmedicine.8220-21

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Relationship Between Procedural Right Bundle Branch Block and 1-Year Outcome After Alcohol Septal Ablation for Hypertrophic Obstructive Cardiomyopathy - A Retrospective Study. Reviewed

Junya Matsuda, Hitoshi Takano, Masaki Morooka, Yoichi Imori, Jun Nakata, Mitsunobu Kitamura, Shuhei Tara, Yukichi Tokita, Takeshi Yamamoto, Morimasa Takayama, Wataru Shimizu

Circulation journal : official journal of the Japanese Circulation Society 85 ( 9 ) 1481 - 1491 2021.8

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BACKGROUND: Alcohol septal ablation (ASA) is a treatment option in patients with drug-refractory symptomatic hypertrophic obstructive cardiomyopathy (HOCM). In many patients, right bundle branch block (RBBB) develops during ASA because septal branches supply the right bundle branch. However, the clinical significance of procedural RBBB is uncertain.Methods and Results:We retrospectively reviewed 184 consecutive patients with HOCM who underwent ASA. We excluded 40 patients with pre-existing RBBB (n=10), prior pacemaker implantation (n=15), mid-ventricular obstruction type (n=10), and those lost to follow-up (n=5), leaving 144 patients for analysis. Patients were divided into 2 groups according to the development (n=95) or not (n=49) of procedural RBBB. ASA conferred significant decreases in the left ventricular pressure gradient (LVPG) in both the RBBB and no-RBBB group (from 74±48 to 27±27 mmHg [P<0.001] and from 75±45 to 31±33 mmHg [P<0.001], respectively). None of the RBBB patients developed further conduction system disturbances. The percentage reduction in LVPG at 1 year after the procedure was significantly greater in the RBBB than no-RBBB group (66±24% vs. 49±45%; P=0.035). Procedural RBBB was not associated with pacemaker implantation after ASA, but was associated with reduction in repeat ASA (odds ratio 0.34; 95% confidence interval 0.13-0.92; P=0.045). CONCLUSIONS: Although RBBB frequently occurs during the ASA procedure, it does not adversely affect clinical outcomes.

DOI： 10.1253/circj.CJ-20-1191

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Hemodynamic Collapse Caused by Cardiac Dysfunction and Abdominal Compartment Syndrome in a Patient with Mitochondrial Disease. Reviewed

Reiko Shiomura, Shuhei Tara, Nobuaki Ito, Makoto Watanabe, Toshiki Arai, Noriyuki Kobayashi, Masaki Wakita, Yuhi Fujimoto, Junya Matsuda, Jun Nakata, Takeshi Yamamoto, Wataru Shimizu

Internal medicine (Tokyo, Japan) 61 ( 4 ) 489 - 493 2021.8

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We herein report a case of mitochondrial disease with heart and intestinal tract involvement resulting in hemodynamic collapse. A 66-year-old woman was transferred to our hospital because of cardiogenic shock. Vasopressors were administered, and a circulatory support device was deployed. However, her hemodynamics did not improve sufficiently, and we detected abdominal compartment syndrome caused by the aggravation of chronic intestinal pseudo-obstruction as a complication. Insertion of a colorectal tube immediately decreased the intra-abdominal pressure, improving the hemodynamics. Finally, we diagnosed her with mitochondrial disease, concluding that the resulting combination of acute heart failure and abdominal compartment syndrome had aggravated the hemodynamics.

DOI： 10.2169/internalmedicine.7729-21

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Clinical characteristics, secondary prevention goal attainment, and outcomes of patients with recurrent acute coronary syndrome. Reviewed

Shuhei Tara, Takeshi Yamamoto, Shin Sakai, Tokuhiro Kimura, Kazuhiro Asano, Yuhi Fujimoto, Reiko Shiomura, Junya Matsuda, Kosuke Kadooka, Kenta Takahashi, Toshinori Ko, Hideto Sangen, Yoshiyuki Saiki, Jun Nakata, Yusuke Hosokawa, Hitoshi Takano, Wataru Shimizu

Journal of Nippon Medical School = Nippon Ika Daigaku zasshi 2021.3

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BACKGROUND: Because acute coronary syndrome (ACS) development worsens the prognosis of patients with coronary artery disease, preventing recurrent ACS is crucial. However, the degree to which secondary prevention treatment goals in recurrent ACS patients are achieved is unknown. METHODS: Consecutive 214 ACS patients were divided into two groups; First ACS (n=182) and Recurrent ACS (n=32), and compared clinical characteristics between the groups. Fifteen patients developed death or cardiovascular (CV) events during hospitalization, and remained 199 patients were followed from the date of hospital discharge to evaluate subsequent CV events. RESULTS: Patients in the Recurrent ACS group were older (76.8±10.8 years vs 68.8±13.4 years, p=0.002) and had a higher rate of diabetes mellitus (DM) (65.6% vs 36.8%, p=0.003) than those in the First ACS group. The attainment rate of low-density lipoprotein cholesterol (LDL-C) < 70mg/dl in the Recurrent ACS group was only 28.1%, despite 68.8% of these patients receiving statin. HbA1c < 7.0% was achieved in 66.7% of recurrent ACS patients who had been diagnosed with DM. Overall, 12.5% of recurrent ACS patients had received optimal treatment for secondary prevention. CV events after hospital discharge were identified in 37.9% of the Recurrent ACS group and 21.2% of the First ACS group (log-rank: p=0.004). However, recurrent ACS was not an independent risk factor for CV events (adjusted hazard ratio: 2.09, 95% confidence interval: 0.95 to 4.63, p=0.068). CONCLUSION: Optimal treatment for secondary prevention in recurrent ACS patients was insufficient. Attainment of the guideline-recommended LDL-C goal for secondary prevention was especially low in recurrent ACS patients.

DOI： 10.1272/jnms.JNMS.2021_88-601

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PCI innovation PCIにおけるImpella補助循環用ポンプカテーテルの有用性

中田淳, 小林典之, 藤本雄飛, 塩村玲子, 松田淳也, 三軒豪仁, 西城由之, 細川雄亮, 太良修平, 山本剛, 高野仁司, 清水渉

日本心血管インターベンション治療学会抄録集 29回 349 - 349 2021.2

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Impella use in patient with hypertrophic obstructive cardiomyopathy complicated by cardiogenic shock associated with atrioventricular disconnection after alcohol septal ablation(和訳中)

松田淳也, 高野仁司, 井守洋一, 時田祐吉, 諸岡雅城, 塩村玲子, 福泉偉, 野間さつき, 久保田芳明, 小宮山英徳, 中田淳, 宮地秀樹, 太良修平, 山本剛, 清水渉

日本心血管インターベンション治療学会抄録集 29回 1382 - 1382 2021.2

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有効なPTSMA治療後に症状改善に至らなかった規定因子の解析

諸岡雅城, 高野仁司, 井守洋一, 松田淳也, 時田祐吉, 福泉偉, 野間さつき, 久保田芳明, 中田淳, 宮地秀樹, 太良修平, 山本剛, 清水渉

日本心血管インターベンション治療学会抄録集 29回 1047 - 1047 2021.2

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虚血性心疾患治療に補助循環をどのように活用するか補助循環装置を用いたAMI心原性ショック治療ショックチームの視点から

中田淳, 小林典之, 藤本雄飛, 塩村玲子, 松田淳也, 三軒豪仁, 西城由之, 細川雄亮, 太良修平, 山本剛, 高野仁司, 清水渉

日本心血管インターベンション治療学会抄録集 29回 443 - 443 2021.2

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Gastrointestinal bleeding increases the risk of subsequent cardiovascular events in patients with acute cardiovascular diseases requiring intensive care

Shin Sakai, Shuhei Tara, Takeshi Yamamoto, Kazuhiro Asano, Tokuhiro Kimura, Yuhi Fujimoto, Reiko Shiomura, Junya Matsuda, Kosuke Kadooka, Kenta Takahashi, Toshinori Ko, Hideto Sangen, Yoshiyuki Saiki, Jun Nakata, Yusuke Hosokawa, Hitoshi Takano, Wataru Shimizu

Heart and Vessels 2021

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Gastrointestinal (GI) bleeding worsens the outcomes of critically ill patients in the intensive care unit (ICU). Owing to a lack of corresponding data, we aimed to investigate whether GI bleeding during cardiovascular-ICU (C-ICU) admission in acute cardiovascular (CV) disease patients is a risk factor for subsequent CV events. Totally, 492 consecutive C-ICU patients (40.9% acute coronary syndrome, 22.8% heart failure) were grouped into GI bleeding (n = 27; 12 upper GI and 15 lower GI) and non-GI bleeding (n = 465) groups. Thirty-nine patients died or developed CV events during hospitalization, and 453 were followed up from the date of C-ICU discharge to evaluate subsequent major adverse CV events. The GI bleeding group had a higher Acute Physiology and Chronic Health Evaluation II score (20.2 ± 8.2 vs. 15.1 ± 6.8, p < 0.001), higher frequency of mechanical ventilator use (29.6% vs. 13.1%, p = 0.039), and longer C-ICU admission duration (8 [5–16] days vs. 5 [3–8] days, p < 0.001) than the non-GI bleeding group. The in-hospital mortality rate did not differ between the groups. Of those who were followed-up, CV events after C-ICU discharge were identified in 34.6% and 14.3% of patients in the GI and non-GI bleeding groups, respectively, during a median follow-up period of 228 days (log rank, p < 0.001). GI bleeding was an independent risk factor for subsequent CV events (adjusted hazard ratio: 2.23, 95% confidence interval: 1.06–4.71; p = 0.035). GI bleeding during C-ICU admission was independently associated with subsequent CV events in such settings.

DOI： 10.1007/s00380-021-01822-1

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Impella導入後の補助循環治療の進歩と臨床展開心原性ショックに対する補助循環治療戦略

中田淳, 山本剛, 茂澤幸右, 山田健太, 岡英一郎, 塩村玲子, 杉崎陽一郎, 松田淳也, 宮地秀樹, 清水渉

人工臓器 49 ( 2 ) S - 94 2020.10

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Impella導入後の補助循環治療の進歩と臨床展開心原性ショックに対する補助循環治療戦略

中田淳, 山本剛, 茂澤幸右, 山田健太, 岡英一郎, 塩村玲子, 杉崎陽一郎, 松田淳也, 宮地秀樹, 清水渉

人工臓器 49 ( 2 ) S - 94 2020.10

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当院におけるトルバプタン導入患者の暦年変化について

関俊樹, 久保田芳明, 松田淳也, 時田祐吉, 岩崎雄樹, 清水渉

日本老年医学会雑誌 57 ( 4 ) 526 - 526 2020.10

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当院におけるトルバプタン導入患者の暦年変化について

関俊樹, 久保田芳明, 松田淳也, 時田祐吉, 岩崎雄樹, 清水渉

日本老年医学会雑誌 57 ( 4 ) 526 - 526 2020.10

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Effects of empagliflozin versus placebo on cardiac sympathetic activity in acute myocardial infarction patients with type 2 diabetes mellitus: The EMBODY trial

Wataru Shimizu, Yoshiaki Kubota, Yu Hoshika, Kosuke Mozawa, Shuhei Tara, Yukichi Tokita, Kenji Yodogawa, Yu Ki Iwasaki, Takeshi Yamamoto, Hitoshi Takano, Yayoi Tsukada, Kuniya Asai, Masaaki Miyamoto, Yasushi Miyauchi, Eitaro Kodani, Masahiro Ishikawa, Mitsunori Maruyama, Michio Ogano, Jun Tanabe, Reiko Shiomura, Isamu Fukuizumi, Junya Matsuda, Satsuki Noma, Hideto Sangen, Hidenori Komiyama, Yoichi Imori, Shunichi Nakamura, Jun Nakata, Hideki Miyachi, Gen Takagi, Takahiro Todoroki, Takeshi Ikeda, Tomoyo Miyakuni, Ayaka Shima, Masato Matsushita, Hirotake Okazaki, Akihiro Shirakabe, Nobuaki Kobayashi, Masamitsu Takano, Yoshihiko Seino, Yugo Nishi, Keishi Suzuki, Junsuke Shibuya, Tsunenori Saito, Hiroyuki Nakano, Morisawa Taichirou, Erito Furuse, Kenji Nakama, Yusuke Hosokawa, Ippei Tsuboi, Hidekazu Kawanaka

Cardiovascular Diabetology 19 ( 1 ) 2020.9

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© 2020 The Author(s). Background: Protection from lethal ventricular arrhythmias leading to sudden cardiac death (SCD) is a crucial challenge after acute myocardial infarction (AMI). Cardiac sympathetic and parasympathetic activity can be noninvasively assessed using heart rate variability (HRV) and heart rate turbulence (HRT). The EMBODY trial was designed to determine whether the Sodium-glucose cotransporter 2 (SGLT2) inhibitor improves cardiac nerve activity. Methods: This prospective, multicenter, randomized, double-blind, placebo-controlled trial included patients with AMI and type 2 diabetes mellitus (T2DM) in Japan; 105 patients were randomized (1:1) to receive once-daily 10-mg empagliflozin or placebo. The primary endpoints were changes in HRV, e.g., the standard deviation of all 5-min mean normal RR intervals (SDANN) and the low-frequency-to-high-frequency (LF/HF) ratio from baseline to 24 weeks. Secondary endpoints were changes in other sudden cardiac death (SCD) surrogate markers such as HRT. Results: Overall, 96 patients were included (46, empagliflozin group; 50, placebo group). The changes in SDANN were + 11.6 and + 9.1 ms in the empagliflozin (P = 0.02) and placebo groups (P = 0.06), respectively. Change in LF/HF ratio was - 0.57 and - 0.17 in the empagliflozin (P = 0.01) and placebo groups (P = 0.43), respectively. Significant improvement was noted in HRT only in the empagliflozin group (P = 0.01). Whereas intergroup comparison on HRV and HRT showed no significant difference between the empagliflozin and placebo groups. Compared with the placebo group, the empagliflozin group showed significant decreases in body weight, systolic blood pressure, and uric acid. In the empagliflozin group, no adverse events were observed. Conclusions: This is the first randomized clinical data to evaluate the effect of empagliflozin on cardiac sympathetic and parasympathetic activity in patients with T2DM and AMI. Early SGLT2 inhibitor administration in AMI patients with T2DM might be effective in improving cardiac nerve activity without any adverse events. Trial Registration: The EMBODY trial was registered by the UMIN in November 2017 (ID: 000030158). UMIN000030158; https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000034442.

DOI： 10.1186/s12933-020-01127-z

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集中治療におけるArtificial Organ Support工夫と実践 Impellaの安全管理出血性合併症への対策

松田淳也, 山本剛, 中田淳, 藤本雄飛, 塩村玲子, 西城由之, 太良修平, 佐々木友子, 市場晋吾, 清水渉

日本集中治療医学会雑誌 27 ( Suppl. ) 332 - 332 2020.9

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CCU滞在中の出血合併症はその後の心血管イベントの危険因子となるか

酒井伸, 太良修平, 藤本雄飛, 塩村玲子, 松田淳也, 西城由之, 中田淳, 細川雄亮, 山本剛, 清水渉

日本集中治療医学会雑誌 27 ( Suppl. ) 474 - 474 2020.9

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心臓血管系集中治療医をどのように育成するべきか? 重症心血管疾患への集学的治療におけるclosed CCUの役割から心臓血管系集中治療医の育成を考える

太良修平, 宮地秀樹, 三軒豪仁, 藤本雄飛, 塩村玲子, 松田淳也, 西城由之, 中田淳, 山本剛, 清水渉

日本集中治療医学会雑誌 27 ( Suppl. ) 360 - 360 2020.9

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心臓血管系集中治療医をどのように育成するべきか? 重症心血管疾患への集学的治療におけるclosed CCUの役割から心臓血管系集中治療医の育成を考える

太良修平, 宮地秀樹, 三軒豪仁, 藤本雄飛, 塩村玲子, 松田淳也, 西城由之, 中田淳, 山本剛, 清水渉

日本集中治療医学会雑誌 27 ( Suppl. ) 360 - 360 2020.9

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CCUに入室した急性心不全患者における血清マグネシウム異常、リン異常の臨床的意義

脇田真希, 太良修平, 藤本雄飛, 塩村玲子, 松田淳也, 西城由之, 中田淳, 時田祐吉, 山本剛, 清水渉

日本集中治療医学会雑誌 27 ( Suppl. ) 488 - 488 2020.9

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亜急性心筋梗塞の予後は良好か?

細川雄亮, 山本剛, 松田淳也, 三軒豪仁, 中田淳, 宮地秀樹, 太良修平, 時田祐吉, 宗像亮, 清水渉

日本集中治療医学会雑誌 27 ( Suppl. ) 474 - 474 2020.9

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心臓血管集中治療室(CCU)に入室した急性心不全患者における入室時血糖値、血糖変動指標の臨床的意義

脇田真希, 長尾元嗣, 久保田芳明, 太良修平, 藤本雄飛, 塩村玲子, 松田淳也, 中田淳, 山本剛, 高木元, 宮本正章, 杉原仁, 清水渉

糖尿病 63 ( Suppl.1 ) S - 230 2020.8

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循環器系救急疾患の医療連携心血管集中治療チームと救急医療チームの連携からみた急性心血管疾患の管理(Management of Acute Cardiovascular Diseases from the Perspective of Cooperation between Cardiovascular Intensive Care Team and Critical Care Medicine Team)

中田淳, 小林典之, 藤本雄飛, 塩村玲子, 松田淳也, 三軒豪仁, 西城由之, 細川雄亮, 太良修平, 山本剛, 高野仁司, 増野智彦, 横堀将司, 横田裕行, 清水渉

日本循環器学会学術集会抄録集 84回シンポジウム17 - 7 2020.7

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循環器系救急疾患の医療連携心血管集中治療チームと救急医療チームの連携からみた急性心血管疾患の管理(Management of Acute Cardiovascular Diseases from the Perspective of Cooperation between Cardiovascular Intensive Care Team and Critical Care Medicine Team)

中田淳, 小林典之, 藤本雄飛, 塩村玲子, 松田淳也, 三軒豪仁, 西城由之, 細川雄亮, 太良修平, 山本剛, 高野仁司, 増野智彦, 横堀将司, 横田裕行, 清水渉

日本循環器学会学術集会抄録集 84回シンポジウム17 - 7 2020.7

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緊急心血管疾患患者におけるCCU滞在時の消化管出血とその後の心血管イベントとの関連(Association between Gastrointestinal Bleeding during CCU Stay and Subsequent Cardiovascular Events in Patients with Emergency Cardiovascular Diseases)

Sakai Shin, Tara Shuhei, Fujimoto Yuhi, Shiomura Reiko, Matsuda Junya, Saiki Yoshiyuki, Nakata Jun, Hosokawa Yusuke, Yamamoto Takeshi, Shimizu Wataru

日本循環器学会学術集会抄録集 84回 OE60 - 5 2020.7

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Delay in seeking treatment before emergent heart failure readmission and its association with clinical phenotype. International journal

Makoto Takei, Kazumasa Harada, Yasuyuki Shiraishi, Junya Matsuda, Yoichi Iwasaki, Yoshiya Yamamoto, Kenichi Matsushita, Tetsuro Miyazaki, Takamichi Miyamoto, Kiyosi Iida, Shuzo Tanimoto, Yuji Nagatomo, Toru Hosoda, Shun Kohsaka, Takeshi Yamamoto, Ken Nagao, Morimasa Takayama

Journal of intensive care 8 65 - 65 2020

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BACKGROUND: Many patients with emergent heart failure (HF) readmission have a delay between symptom onset and hospitalization. The present study aimed to characterize the interval between symptom onset and hospitalization in patients being readmitted for HF and to compare the clinical phenotypes of patients with delay before emergent readmission with those who presented to the hospital earlier. METHODS: Data for a total of 2073 consecutive patients was collected from the Tokyo CCU Network database; the patients were divided into delayed (those who sought medical help > 2 days after symptom onset; n = 271) and early groups (remaining patients; n = 1802), and their clinical characteristics and mode of presentation were compared. RESULTS: Age, sex, and laboratory findings including brain natriuretic peptide and serum creatinine levels were not significantly different between the two groups. Patients in the delayed group had greater chronic fluid retention and symptoms not associated with respiratory failure, whereas those in the early group were more likely to have acute respiratory distress, faster heart and respiration rates, and higher systolic blood pressure. CONCLUSIONS: More than one in ten patients with HF readmission delay seeking treatment > 2 days after symptom onset. Patients who delayed seeking treatment showed the phenotype of chronic fluid retention, whereas those who presented to the hospital earlier had the phenotype of acute respiratory failure.

DOI： 10.1186/s40560-020-00482-z

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Bisoprolol transdermal patch for perioperative care of non-cardiac surgery in patients with hypertrophic obstructive cardiomyopathy. Reviewed

Imori Y, Takano H, Mase H, Matsuda J, Sangen H, Izumi Y, Tokita Y, Yamamoto T, Shimizu W

BMC cardiovascular disorders 19 ( 1 ) 316 2019.12

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DOI： 10.1186/s12872-019-01274-6

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順行性及び逆行性アプローチによる慢性完全閉塞性病変治療後の慢性期ステント部血管内視鏡所見に関する検討

福泉偉, 時田祐吉, 塩村玲子, 野間さつき, 松田淳也, 久保田芳明, 井守洋一, 西城由之, 中田淳, 宮地秀樹, 太良修平, 高野仁司, 清水渉

日本冠疾患学会誌 ( Suppl.2019 ) 168 - 168 2019.12

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側壁心筋梗塞後心破裂から心嚢血腫をきたし、遅発性心タンポナーデに陥り治療方針の決定に苦慮した1例

茂澤幸右, 松田淳也, 細川雄亮, 鈴木憲治, 村田智洋, 佐藤達志, 木村徳宏, 浅野和宏, 藤本竜平, 三軒豪仁, 中田淳, 太良修平, 山本剛, 高野仁司, 新田隆, 清水渉

ICUとCCU 43 ( 別冊 ) S115 - S115 2019.12

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Percutaneous transluminal septal myocardial ablation for hypertrophic obstructive cardiomyopathy through non-left anterior descending septal perforators. Reviewed

Imori Y, Takano H, Kitamura M, Aoyama R, Sangen H, Kenta O, Matsuda J, Kubota Y, Tokita Y, Yamamoto T, Asai K, Takayama M, Shimizu W

Heart and vessels 2019.10

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DOI： 10.1007/s00380-019-01525-8

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Daily risk of adverse outcomes in patients undergoing complex lesions revascularization: A subgroup analysis from the RAIN-CARDIOGROUP VII study (veRy thin stents for patients with left mAIn or bifurcatioN in real life). International journal

Carloalberto Biolè, Zenon Huczek, Ivan Nuñez-Gil, Giacomo Boccuzzi, Michele Autelli, Antonio Montefusco, Daniela Trabattoni, Nicola Ryan, Giuseppe Venuti, Yoichi Imori, Hitoshi Takano, Junya Matsuda, Wataru Shimizu, Saverio Muscoli, Andrea Montabone, Wojciech Wojakowski, Andrea Rognoni, Gerard Helft, Diego Gallo, Radoslaw Parma, Leonardo De Luca, Filippo Figini, Satoru Mitomo, Mauro Pennone, Alessio Mattesini, Christian Templin, Giorgio Quadri, Wojciech Wańha, Enrico Cerrato, Grzegorz Smolka, Marcin Protasiewicz, Wiktor Kuliczkowski, Cristina Rolfo, Bernardo Cortese, Davide Capodanno, Alaide Chieffo, Umberto Morbiducci, Mario Iannaccone, Sebastiano Gili, Carlo di Mario, Maurizio D'Amico, Francesco Romeo, Thomas F Lüscher, Imad Sheiban, Javier Escaned, Ferdinando Varbella, Fabrizio D'Ascenzo

International journal of cardiology 290 64 - 69 2019.9

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INTRODUCTION: Percutaneous coronary intervention (PCI) for complex lesions, including unprotected left main (ULM) and bifurcations, is gaining a relevant role in treating coronary artery disease with good outcomes, also thanks to new generation stents. The daily risk of adverse cardiovascular events and their temporal distribution after these procedures is not known. METHODS: All consecutive patients presenting with a critical lesion of ULM or bifurcation treated with very thin struts stents, enrolled in the RAIN-Cardiogroup VII study, were analyzed. The daily risk of major acute cardiovascular events (MACE), target lesion revascularization (TLR) and stent thrombosis (ST) and their temporal distribution in the first year of follow-up was the primary endpoint. Differences among subgroups (ULM, patient presentation, kind of stent polymer) were the secondary endpoint. RESULTS: 2745 patients were included, mean age 68 ± 11 years, 33.3% diabetics, 54.5% had an acute coronary syndrome (ACS); 88.5% of treated lesions were bifurcations, 27.2% ULM. Average daily risk was 0.022% for MACE, 0.005% for TLR and 0.004% for ST, in the first year. Bimodal distribution of adverse events, especially TLR, with an early peak in the first 50 days and a late one after 150 days, was observed. Patients with ULM presented a significantly higher daily risk of events, and ACS patients presented higher MACE risk. No difference emerged according to the type of stent polymer. CONCLUSIONS: The daily risk of adverse events in the first year after complex PCI in our study is acceptably low. PCI on ULM carries a higher risk of complications.

DOI： 10.1016/j.ijcard.2019.03.038

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4D flow MRIを用いた閉塞性肥大型心筋症に対する血流解析

松田淳也, 高野仁司, 関根鉄郎, 三軒豪仁, 久保田芳明, 井守洋一, 中田淳, 西城由之, 宮地秀樹, 太良修平, 時田祐吉, 山本剛, 汲田伸一郎, 清水渉

日本心臓病学会学術集会抄録 67回 O - 019 2019.9

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心原性ショックを伴う急性心筋梗塞に対するImpella補助の有効性に関する検討

松田淳也, 中田淳, 山本剛, 藤本雄飛, 塩村玲子, 野間さつき, 三軒豪仁, 久保田芳明, 井守洋一, 西城由之, 宮地秀樹, 太良修平, 細川雄亮, 時田祐吉, 高野仁司, 清水渉

日本心血管インターベンション治療学会抄録集 28回 [MO71 - 002] 2019.9

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Hemodynamics assist device:when and how to use? インペラを用いた心原性ショック治療戦略

中田淳, 松田淳也, 三軒豪仁, 西城由之, 太良修平, 細川雄亮, 山本剛, 高野仁司, 清水渉

日本心血管インターベンション治療学会抄録集 28回 [S37 - 2] 2019.9

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Recent MIの予後は良好か?

細川雄亮, 山本剛, 松田淳也, 三軒豪仁, 中田淳, 宮地秀樹, 太良修平, 時田祐吉, 高野仁司, 清水渉

日本心血管インターベンション治療学会抄録集 28回 [MO79 - 004] 2019.9

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家族性コレステロール血症のない患者におけるアキレス腱肥厚と冠動脈アテローム性動脈硬化症の重症度との関連性

星加優, 高野仁司, 久保田芳明, 福泉偉, 野間さつき, 松田淳也, 三軒豪仁, 井守洋一, 西城由之, 中田淳, 宮地秀樹, 細川雄亮, 太良修平, 時田祐吉, 山本剛, 清水渉

日本心血管インターベンション治療学会抄録集 28回 [MP5 - 006] 2019.9

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Double balloon techniqueにより標的中隔心筋を分離させ経皮的中隔心筋焼灼術を行い得た3例

松田淳也, 高野仁司, 井守洋一, 時田祐吉, 三軒豪仁, 福泉偉, 野間さつき, 久保田芳明, 西城由之, 中田淳, 宮地秀樹, 太良修平, 細川雄亮, 山本剛, 清水渉

日本心血管インターベンション治療学会抄録集 28回 [MO34 - 002] 2019.9

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心原性ショックを呈した3枝病変合併重症大動脈弁狭窄症に対し、Impella補助下にBAV、PCIを施行し、救命し得た一例

三軒豪仁, 木村徳弘, 関俊樹, 福泉偉, 塩村玲子, 野間さつき, 松田淳也, 中村有希, 久保田芳明, 井守洋一, 西城由之, 中田淳, 宮地秀樹, 細川雄亮, 太良修平, 時田祐吉, 山本剛, 高野仁司, 清水渉

日本心血管インターベンション治療学会抄録集 28回 [MO104 - 001] 2019.9

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重症急性心筋梗塞に挑む Impellaを用いた重症心筋梗塞治療

中田淳, 藤本雄飛, 塩村玲子, 松田淳也, 三軒豪仁, 西城由之, 太良修平, 細川雄亮, 山本剛, 高野仁司, 清水渉

日本心臓病学会学術集会抄録 67回 S - 6 2019.9

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東京都における三次救急選定された急性心筋梗塞の検討

三軒豪仁, 木村徳弘, 塩村玲子, 松田淳也, 西城由之, 中田淳, 細川雄亮, 太良修平, 山本剛, 高野仁司, 清水渉

日本心血管インターベンション治療学会抄録集 28回 [MO50 - 004] 2019.9

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Four-dimentional Flow MRI reveals the reduction in turbulent kinetic energy after percutaneous transluminal septal myocardial ablation in hypertrophic obstructive cardiomyopathy. Reviewed

Iwata K, Matsuda J, Imori Y, Sekine T, Takano H, Co

European Heart Journal 2019.8

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当院における重症肺塞栓症の治療成績と今後の課題

細川雄亮, 山本剛, 谷田篤史, 松田淳也, 三軒豪仁, 林洋史, 中田淳, 宮地秀樹, 太良修平, 時田祐吉, 清水渉

心臓 51 ( 7 ) 753 - 753 2019.7

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2019&ichushi_jid=J00679&link_issn=&doc_id=20190719190020&doc_link_id=%2Fah2sinzd%2F2019%2Fs05107%2F003%2F0753-0753%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fah2sinzd%2F2019%2Fs05107%2F003%2F0753-0753%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif
Predictors of responders for low-dose carperitide monotherapy in patients with acute heart failure. Reviewed

Masataka Kamiya, Naoki Sato, Junya Matsuda, Ayaka Nozaki, Mai Akiya, Taisuke Sato, Hirotake Okazaki, Yasuhiro Takahashi, Wataru Shimizu

Heart and vessels 35 ( 1 ) 59 - 68 2019.6

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Human atrial natriuretic peptide, known as carperitide, is approved for early relief of dyspnea in patients with acute heart failure (AHF). However, the diuretic effect of carperitide is sometimes insufficient for controlling volume overload. We investigated predictors for the carperitide response in patients with AHF. Forty-seven patients (age: 74 ± 10 years; left ventricular ejection fraction: 42.0% ± 15.9%) with AHF were enrolled and treated with carperitide monotherapy at a dose of 0.0125 μg/kg/min. Patients without sufficient diuresis (< 60 ml/h) or improvement of symptoms by 4 h after carperitide administration, despite increasing to twice the dose of carperitide and adding another agent, were defined as non-responders. Twenty-four (51%) patients were defined as responders and treated with low-dose carperitide monotherapy on the first day. Multiple logistic regression analysis showed that the response to carperitide monotherapy was independently predicted by serum creatinine levels and systolic blood pressure (SBP) on admission. The area under the receiver-operating characteristic curve for predicting the response to carperitide by SBP was 0.808 (95% confidence interval [0.686-0.930], sensitivity: 83.3%, specificity: 65.2%, cutoff value: 135 mmHg). Four (8.5%) patients developed asymptomatic transient hypotension. Worsening renal function occurred within 3 days of admission in three (6.4%) patients who received low-dose carperitide therapy. SBP and serum creatinine levels on admission might be useful for predicting the diuretic response to low-dose carperitide monotherapy in patients with AHF. Initial use of low-dose carperitide therapy does not have adverse effects on renal function.

DOI： 10.1007/s00380-019-01450-w

PubMed

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心血管病を診断・治療する新しいモダリティ心原性ショック治療における新しい補助循環デバイス"Impella"

中田淳, 山本剛, 浅野和弘, 木村徳宏, 松田淳也, 三軒豪仁, 細川雄亮, 太良修平, 清水渉

日本循環制御医学会総会プログラム・抄録集 40回 39 - 39 2019.6

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ST上昇型心筋梗塞(STEMI)による難治性心原性ショック患者におけるImpellaによるLV負荷軽減の有益性(Benefit of LV Unloading by Means of Impella in Patients with Refractory Cardiogenic Shock for ST-Elevation Myocardial Infarction(STEMI))

中田淳, 堤正将, 浅野和宏, 木村徳宏, 関俊樹, 門岡浩介, 松田淳也, 三軒豪仁, 細川雄亮, 太良修平, 山本剛, 高野仁, 清水渉

日本循環器学会学術集会抄録集 83回 OJ41 - 3 2019.3

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肥大型閉塞性心筋症に対するアルコール中隔アブレーション後における右脚ブロックまたは二束ブロックと転帰の関連(Relationship between Post-procedural Right Bundle Branch or Bifascicular Block and Outcome after Alcohol Septal Ablation for Hypertrophic Obstructive Cardiomyopathy)

松田淳也, 高野仁司, 井守洋一, 野間さつき, 高圓雅博, 中村有希, 三軒豪仁, 久保田芳明, 中田淳, 西城由之, 宮地秀樹, 太良修平, 細川雄亮, 時田祐吉, 山本剛, 清水渉

日本循環器学会学術集会抄録集 83回 OJ19 - 8 2019.3

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心原性ショックを合併する急性心筋梗塞における左室の早期の機械低減負荷の方法(Early Left Ventricular Mechanical Unloading Strategy in Acute Myocardial Infarction Complicated by Cardiogenic Shock)

三軒豪仁, 山本剛, 佐藤達志, 茂澤幸右, 堤正将, 関俊樹, 浅野和宏, 木村徳宏, 脇田真希, 笹本希, 福泉偉, 小野寺健太, 野間さつき, 松田淳也, 黄俊憲, 高橋健太, 中村有希, 林洋史, 久保田芳明, 井守洋一, 中田淳, 西城由之, 宮地秀樹, 細川雄亮, 太良修平, 時田祐吉, 高野仁司, 清水渉

日本循環器学会学術集会抄録集 83回 PJ045 - 7 2019.3

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冠動脈疾患患者におけるアキレス腱厚は冠動脈プラークの脂質コア容量と関連している(Achilles Tendon Thickness is Associated with Lipid Core Volume of Coronary Plaques in Patients with Coronary Artery Disease)

野間さつき, 高野仁司, 久保田芳明, 星加優, 松田淳也, 三軒豪仁, 井守洋一, 西城由之, 中田淳, 宮地秀樹, 細川雄亮, 太良修平, 時田祐吉, 山本剛, 清水渉

日本循環器学会学術集会抄録集 83回 PJ029 - 3 2019.3

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経皮的冠動脈インターベンション後無症状が続く患者においてSyntaxスコア変化が長期予後に及ぼす影響(The Impact of Change of Syntax Score on the Long-Term Prognosis in Patients Staying Asymptomatic after Percutaneous Coronary Intervention)

Nakamura Yuuki, Tokita Yukichi, Noma Satsuki, Matsuda Junya, Koen Masahiro, Sangen Hideto, Kubota Yoshiaki, Imori Yoichi, Nakata Jun, Saiki Yoshiyuki, Miyachi Hideki, Tara Shuhei, Hosokawa Yusuke, Yamamoto Takeshi, Takano Hitoshi, Shimizu Wataru

日本循環器学会学術集会抄録集 83回 PE07 - 3 2019.3

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洋上救急医療によって救命し得た劇症型心筋炎の一例

井上正章, 富永直樹, 中野祐太, 萩原純, 中江竜太, 金史英, 松田淳也, 木村徳宏, 三軒豪仁, 中田淳, 細川雄亮, 太良修平, 山本剛, 清水渉, 横田裕行

日本救急医学会関東地方会雑誌 40 ( 1 ) 106 - 106 2019.2

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心タンポナーデによる閉塞性ショックから重度の低酸素性肝炎を呈した心筋梗塞後左室自由壁破裂の一例

藤本竜平, 松田淳也, 細川雄亮, 中田淳, 三軒豪仁, 浅野和弘, 木村徳宏, 太良修平, 山本剛, 清水渉

日本救急医学会関東地方会雑誌 40 ( 1 ) 93 - 93 2019.2

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補助循環の安全管理・最前線小型心臓ポンプカテーテルImpellaを用いた心原性ショック治療におけるショックチームの重要性

中田淳, 山本剛, 藤本竜平, 浅野和宏, 木村徳宏, 松田淳也, 三軒豪仁, 細川雄亮, 太良修平, 清水渉

日本集中治療医学会雑誌 26 ( Suppl. ) [SY22 - 9] 2019.2

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大量冠動脈内血栓を伴うSTEMIに対するprimary PCIにおける経カテーテル的t-PA投与の治療効果

野間さつき, 宮地秀樹, 高木宏治, 福泉偉, 松田淳也, 三軒豪人, 久保田芳明, 井守洋一, 西城由之, 細川雄亮, 太良修平, 時田祐吉, 山本剛, 高野仁司, 清水渉

日本冠疾患学会雑誌 ( Suppl. ) 162 - 162 2018.11

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PCI後、抗血小板療法中の患者における消化管出血発症率

木村徳宏, 高野仁司, 久保田芳明, 野間さつき, 松田淳也, 三軒豪仁, 井守洋一, 西城由之, 宮地秀樹, 細川雄亮, 太良修平, 時田祐吉, 山本剛, 清水渉

日本冠疾患学会雑誌 ( Suppl. ) 143 - 143 2018.11

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著明な石灰化を伴いロータブレーターを要したステント内再狭窄の一例

関俊樹, 時田祐吉, 高野仁司, 松田淳也, 野間さつき, 三軒豪仁, 井守洋一, 久保田芳明, 中田淳, 西城由之, 宮地秀樹, 細川雄亮, 太良修平, 山本剛, 清水渉

日本冠疾患学会雑誌 ( Suppl. ) 163 - 163 2018.11

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急性心筋梗塞患者における冠動脈塞栓の発症率とPCI戦略

辻林亨, 高野仁司, 野間さつき, 松田淳也, 三軒豪仁, 久保田芳明, 井守洋一, 西城由之, 中田淳, 宮地秀樹, 細川雄亮, 太良修平, 時田祐吉, 山本剛, 清水渉

日本冠疾患学会雑誌 ( Suppl. ) 162 - 162 2018.11

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冠動脈塞栓に起因した急性心筋梗塞に対する治療戦略の検討

辻林亨, 高野仁司, 野間さつき, 松田淳也, 三軒豪仁, 久保田芳明, 井守洋一, 西城由之, 中田淳, 宮地秀樹, 細川雄亮, 太良修平, 時田祐吉, 山本剛, 清水渉

日本心臓病学会学術集会抄録 66回 EP - 004 2018.9

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経皮的冠動脈インターベンション後無症候で経過している患者における遠隔期Syntaxスコアの進行に関する検討

中村有希, 時田祐吉, 高野仁司, 野間さつき, 松田淳也, 三軒豪仁, 久保田芳明, 井守洋一, 中田淳, 宮地秀樹, 細川雄亮, 太良修平, 山本剛, 浅井邦也, 清水渉

日本心臓病学会学術集会抄録 66回 EP - 210 2018.9

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本邦における心原性ショックの現状と対策 Impella時代到来後の重症心筋梗塞に対するインターベンショニストのアプローチ "重症心筋梗塞はどこに搬送されているのか?"

三軒豪仁, 山本剛, 野間さつき, 松田淳也, 門岡浩介, 中村有希, 久保田芳明, 井守洋一, 中田淳, 宮地秀樹, 太良修平, 細川雄亮, 時田祐吉, 高野仁司, 浅井邦也, 清水渉

日本心血管インターベンション治療学会抄録集 27回 SY8 - 4 2018.8

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Chronic phase improvements in electrocardiographic and echocardiographic manifestations of left ventricular hypertrophy after alcohol septal ablation for drug-refractory hypertrophic obstructive cardiomyopathy Reviewed

Junya Matsuda, Mitsunobu Kitamura, Morimasa Takayama, Yoichi Imori, Junsuke Shibuya, Yoshiaki Kubota, Hideto Sangen, Shunichi Nakamura, Hitoshi Takano, Kuniya Asai, Wataru Shimizu

Heart and Vessels 33 ( 3 ) 246 - 254 2018.3

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Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) Publisher：Springer Tokyo

After alcohol septal ablation (ASA), regression of left ventricular hypertrophy (LVH) has been observed in several studies using echocardiography or cardiac magnetic resonance, and favorable changes of myocardial excitation have been expected. However, no studies have focused on the alteration of electrocardiography (ECG) findings after ASA. Therefore, we evaluated serial changes in ECG parameters during the chronic phase after ASA for drug-refractory hypertrophic obstructive cardiomyopathy (HOCM). From 1998 to 2014, we performed 187 ASA procedures in 157 drug-refractory HOCM patients. After excluding patients who underwent dual-chamber pacing therapy and who underwent staged or repeat ASA within 2 years after the index ASA, 25 patients without bundle branch block and additional pacemaker implantation were enrolled in the main study group. ECGs, echocardiograms, and clinical follow-up data were evaluated at baseline and, 1, 6, 12, and 24 months after ASA. Patients with bundle branch block or additional pacemaker implantation were assigned in a referential group (n = 79), in which the echocardiographic changes between baseline and at 1 year were evaluated. Sokolow–Lyon index (SLi), Cornell index, and total 12-lead QRS amplitude significantly decreased during 2-year follow-up after ASA. SLi and Cornell index significantly decreased from 6 to 12 months (p &lt
0.05 vs. p &lt
0.01). Changes in SLi were significantly associated with changes in the interventricular septal thickness (r = 0.54, p &lt
0.005), left ventricular mass index (r = 0.40, p = 0.050), and peak creatine phosphokinase level (r = −0.41, p = 0.042), but not in the Cornell index and 12-lead QRS amplitude. In the comparison between baseline and at 1 year, significant improvements in the interventricular septal thickness, posterior wall thickness, left atrial size, E/A ratio, and E/e′ were observed in the echocardiographic study. Changes of SLi reflected regression of LVH after ASA with the best correlation. During the chronic phase after ASA, LVH regression was confirmed by echocardiographic and ECG parameters.

DOI： 10.1007/s00380-017-1053-9

Scopus

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アルコール中隔焼灼術が肥大型閉塞性心筋症患者の左室拡張機能に及ぼす効果(Impact of Alcohol Septal Ablation on Left Ventricular Diastolic Function in Patients with Hypertrophic Obstructive Cardiomyopathy)

轟崇弘, 高野仁司, 井守洋一, 泉佑樹, 小野寺健太, 松田淳也, 北村光信, 三軒豪仁, 野間さつき, 黄俊憲, 中村有希, 久保田芳明, 細川雄亮, 太良修平, 時田祐吉, 山本剛, 浅井邦也, 清水渉

日本循環器学会学術集会抄録集 82回 PJ040 - 1 2018.3

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非閉塞性腸間膜虚血に急性下肢虚血が続発し救命し得た一例

栗原健, 松田淳也, 塩村玲子, 福泉偉, 佐藤太亮, 高橋保裕, 清水渉

日本集中治療医学会雑誌 25 ( Suppl. ) [O7 - 1] 2018.2

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IgG4-related periarteritis in the coronary artery and subclinical pericarditis assessed the presence and monitoring of therapy response by PET and CT scan Reviewed

Junya Matsuda, Hitoshi Takano, Wataru Shimizu

BMJ Case Reports 2018 2018

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DOI： 10.1136/bcr-2018-225172

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Usefulness of Non-Anteroseptal Region Left Ventricular Hypertrophy Using Cardiac Magnetic Resonance to Predict Repeat Alcohol Septal Ablation for Refractory Obstructive Hypertrophic Cardiomyopathy Reviewed

Mitsunobu Kitamura, Yasuo Amano, Morimasa Takayama, Junsuke Shibuya, Junya Matsuda, Hideto Sangen, Shunichi Nakamura, Hitoshi Takano, Kuniya Asai, Shinichiro Kumita, Wataru Shimizu

AMERICAN JOURNAL OF CARDIOLOGY 120 ( 1 ) 124 - 130 2017.7

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Language：English Publishing type：Research paper (scientific journal) Publisher：EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC

We evaluated a cohort of patients treated with alcohol septal ablation (ASA) to identify predictive factors for repeat ASA. We compared 15 patients who underwent repeat ASA procedures (group R) with 69 patients not requiring repeat procedures (group S) in terms of clinical parameters and morphologic cardiac magnetic resonance. Group R showed higher number of hypertrophic segments (thickness >= 15 mm) in the basal left ventricular level (2.8 +/- 1.7 vs 1.7 +/- 0.8, p = 0.009) than group S. In the multivariate analysis, diuretics use (adjusted odds ratio 5.8, 95% confidential interval [CI] 1.04 to 32.2, p = 0.045) and the number of non anteroseptal extended hypertrophy segments at the basal level were independent predictors of a repeat ASA procedure (adjusted odds ratio 3.64/segment, 95% CI 1.40 to 9.4, p = 0.008). One repeat ASA among 21 patients without non anteroseptal hypertrophy and 1 repeat ASA among 29 patients without posteroseptal hypertrophy were observed; however, 7 of the 14 patients with >= 2 segments of non anteroseptal hypertrophy received repeat ASA. In conclusion, cardiac magnetic resonance based cross-sectional investigation elucidated non anteroseptal hypertrophy segments) to be a crucial predictor of repeat ASA. ASA is useful for patients with regional hypertrophy in the basal anteroseptal, but not posteroseptal region, and without heart failure requiring diuretics. (C) 2017 Elsevier Inc. All rights reserved.

DOI： 10.1016/j.amjcard.2017.03.248

Web of Science

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穿刺部合併症の現状と対策 PCPS動脈大口径カニューレ抜去における経皮的止血デバイスの有用性

高橋保裕, 福泉偉, 松田淳也, 羽田朋人, 佐藤太亮, 清水渉

日本心血管インターベンション治療学会抄録集 25回 S04 - 5 2016.7

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Clinical Characteristics and Outcome of Alcohol Septal Ablation With Confirmation by Nitroglycerin Test for Drug-Refractory Hypertrophic Obstructive Cardiomyopathy With Labile Left Ventricular Outflow Obstruction. Reviewed

Kitamura M, Takayama M, Matsuda J, Kubota Y, Nakamura S, Takano H, Asai K, Shimizu W

The American journal of cardiology 116 ( 6 ) 945 - 951 2015.9

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DOI： 10.1016/j.amjcard.2015.06.023

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薬剤抵抗性循環不全を伴う閉塞性肥大型心筋症へのカテーテル治療・体外式ペースメーカー併用の臨床的意義

北村光信, 藤本雄飛, 澁谷淳介, 松田淳也, 吉真孝, 宮地秀樹, 細川雄亮, 圷宏一, 山本剛, 清水渉

日本集中治療医学会雑誌 22 ( Suppl. ) [DP32 - 5] 2015.1

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Prognostic values of highly sensitive cardiac troponin T and B-type natriuretic peptide for clinical features in hypertrophic obstructive cardiomyopathy: a cross-sectional study. Reviewed

Nakamura S, Takano H, Matsuda J, Chinen D, Kitamura M, Murai K, Asai K, Yasutake M, Takayama M, Shimizu W

BMJ open 4 ( 9 ) e005968 2014.9

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DOI： 10.1136/bmjopen-2014-005968

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Giant left atrium due to mitral stenosis with massive atelectasis: A successful case with perioperative approach Reviewed

Atsushi Tanita, Yusuke Hosokawa, Takeshi Tomiyama, Maiko Kato, Junya Matsuda, Keisuke Sawai, Yoshie Arita, Toshiyuki Aokage, Hiroomi Suzuki, Hiroshige Murata, Hideki Miyachi, Toshiyuki Shibui, Takahito Nei, Koichi Akutsu, Takeshi Yamamoto, Shinhiro Takeda, Takashi Nitta, Kunio Tanaka, Kyoichi Mizuno, Keiji Tanaka

INTERNATIONAL JOURNAL OF CARDIOLOGY 163 ( 2 ) E23 - E25 2013.2

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DOI： 10.1016/j.ijcard.2012.08.037

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A case of rapid diagnosis of Boerhaave syndrome by thoracic drainage. International journal

Manabu Suzuki, Naoki Sato, Junya Matsuda, Naoya Niwa, Koji Murai, Takeshi Yamamoto, Shinhiro Takeda, Kengo Shigehara, Tsutomu Nomura, Akihiko Gamma, Keiji Tanaka

The Journal of emergency medicine 43 ( 6 ) e419-23 2012.12

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BACKGROUND: Boerhaave syndrome is a rare and often fatal syndrome. Delayed diagnosis and treatment is closely associated with prolonged morbidity and increased mortality. In general, esophagography is usually chosen as the diagnostic procedure, but it has a relatively high false-negative rate. There are no reports, to our knowledge, regarding the efficacy of thoracic drainage, although it is easier to perform and more immediate than esophagography in the emergency department. OBJECTIVES: To report the efficacy of thoracic drainage for rapid diagnosis and treatment of Boerhaave syndrome. CASE REPORT: An 80-year-old woman was admitted with vomiting and sudden onset of postprandial chest pain radiating to the back. Initially, myocardial infarction or aortic dissection was suspected, but was excluded by point-of-care tests and computed tomography (CT) scan, which revealed a left-sided pneumothorax, heterogeneous left pleural effusion, and pneumomediastinum at the lower level of the esophagus. Boerhaave syndrome was suspected and confirmed by thoracic drainage, which drained off bloody fluid and residual food such as broccoli. Emergency thoracotomy was performed within 4 h after onset of symptoms. The patient made an uneventful recovery. CONCLUSION: Findings in this case indicate that chest pain, left-sided massive effusion on chest radiography, and left-sided massive heterogeneous effusion on CT scan are important for the diagnosis of Boerhaave syndrome. Subsequent thoracic drainage is useful for confirming Boerhaave syndrome, and such a strategy might lead to a good prognosis for patients with this rare but critical disease.

DOI： 10.1016/j.jemermed.2011.05.079

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多発性IgG4関連疾患に伴う冠動脈・心病変の活動性評価にFDG-PET/CTが有用であった1例

小林靖宏, 天野康雄, 高野仁司, 松田淳也, 石原圭一, 秋山一義, 佐藤英尊, 林宏光, 水野杏一, 汲田伸一郎

日独医報 57 ( 1 ) 106 - 106 2012.8

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The Impact of Intraprocedural Echocardiographic Findings during Percutaneous Transluminal Septal Myocardial Ablation on Long-term Improvement in Hypertrophic Obstructive Cardiomyopathy

松田淳也, 時田祐吉, 星加りさ, 石原翔, 小林芹奈, 内山沙央里, 萩原かな子, 小野有希, 井守洋一, 久保田芳明, 小玉麻衣, 中田淳, 宮地秀樹, 太良修平, 山本剛, 高野仁司, 浅井邦也

日本循環器学会学術集会(Web) 88th 2024

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Impact of the COVID-19 Pandemic on Acute Heart Failure Practice: Insights from Tokyo CCU Network Database

中野宏己, 中野宏己, 山下淳, 原田和昌, 白石泰之, 武井眞, 松田淳也, 進藤彰人, 木庭新治, 北野大輔, 河野隆志, 神馬崇宏, 塚本茂人, 松下健一, 香坂俊, 山本剛, 高山守正

日本循環器学会学術集会(Web) 88th 2024

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The Incidence of Left Atrial Appendage Thrombus in Hypertrophic Cardiomyopathy Patients with Atrial Fibrillation

石原翔, 時田祐吉, 星加りさ, 内山沙央里, 小林芹奈, 萩原かな子, 松田淳也, 小野有希, 井守洋一, 久保田芳明, 小玉麻衣, 高野仁司, 浅井邦也

日本循環器学会学術集会(Web) 88th 2024

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運動負荷により左室流出路狭窄が誘発された閉塞性肥大型心筋症の一例

宮川慶大, 内山沙央里, 小山賢太郎, 小林芹奈, 中村有希, 松田淳也, 小玉麻衣, 時田祐吉, 高野仁司, 淺井邦也

日本臨床生理学会雑誌 54 ( 4 ) 2024

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退院処方日数と初回受診日の差異が予後に与える影響心不全患者における検討

西野拓也, 久保田芳明, 林太祐, 渡邉将央, 太良修平, 加藤活人, 茂澤幸右, 松田淳也, 時田祐吉, 岩崎雄樹, 安武正弘, 清水渉

日本循環器学会学術集会抄録集 87回 CP21 - 6 2023.3

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Relationship between Phase Angle and Peak Oxygen Uptake or Skeletal Muscle-related Indices in Men with Heart Failure(タイトル和訳中)

Koen Masahiro, Matsuda Junya, Tokita Miwa, Katoh Kazuyo, Takahashi Hiroshi, Akutsu Koichi, Shimizu Wataru, Takano Hitoshi

日本循環器学会学術集会抄録集 87回 PE66 - 6 2023.3

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Forecasting the Acute Heart Failure Admissions: Development of Deep Learning Prediction Model Incorporating the Climate Information

神馬崇宏, 小寺聡, 香坂俊, 原田和昌, 白石泰之, 木庭新治, 武井眞, 河野隆志, 松下健一, 中野宏己, 宮崎哲朗, 塚本茂人, 松田淳也, 進藤彰人, 北野大輔, 山本剛, 長尾建, 高山守正

ICUとCCU 47 2023

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心不全治療におけるポリファーマシーは患者の死亡率に影響を与えるのか

林太祐, 久保田芳明, 西野拓也, 渡邉将央, 太良修平, 加藤活人, 茂澤幸右, 松田淳也, 時田祐吉, 伊勢雄也, 岩崎雄樹, 安武正弘, 清水渉

日本循環器学会学術集会(Web) 87th 2023

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Impact of Red Blood Cell Transfusion on Subsequent Cardiovascular Events in Heart Failure Patients with Anemia: A Propensity Score-matching Analysis

渡邉将央, 太良修平, 西野拓也, 加藤活人, 久保田芳明, 林太祐, 茂澤幸右, 松田淳也, 宮地秀樹, 時田祐吉, 八島正明, 岩崎雄樹, 安武正弘, 清水渉

日本循環器学会学術集会(Web) 87th ( 2 ) 190 - 198 2023

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Red blood cell (RBC) transfusion therapy is often performed in patients with acute heart failure (AHF) and anemia; however, its impact on subsequent cardiovascular events is unclear. We examined whether RBC transfusion influences major adverse cardiovascular events (MACE) after discharge in patients with AHF and anemia.We classified patients with AHF and anemia (nadir hemoglobin level < 10 g/dL) according to whether they received RBC transfusion during hospitalization. The endpoint was MACE (composite of all-cause death, non-fatal acute coronary syndrome/stroke, or heart failure readmission) 180 days after discharge. For survival analysis, we used propensity score matching analysis with the log-rank test. As sensitivity analysis, we performed inverse probability weighting analysis and multivariable Cox regression analysis.Among 448 patients with AHF and anemia (median age, 81 years; male, 55%), 155 received RBC transfusion and 293 did not. The transfused patients had worse clinical features than the non-transfused patients, with lower levels of nadir hemoglobin and serum albumin and a lower estimated glomerular filtration rate. In the propensity-matched cohort of 87 pairs, there was no significant difference in the MACE-free survival rate between the 2 groups (transfused, 73.8% vs. non-transfused, 65.3%; P = 0.317). This result was consistent in the inverse probability weighting analysis (transfused, 76.0% vs. non-transfused, 68.7%; P = 0.512), and RBC transfusion was not significantly associated with post-discharge MACE in the multivariable Cox regression analysis (adjusted hazard ratio: 1.468, 95% confidence interval: 0.976-2.207; P = 0.065).In conclusion, this study suggests that RBC transfusions for anemia may not improve clinical outcomes in patients with AHF.

DOI： 10.1536/ihj.23-596

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最適な退院処方日数をチーム医療で考える

林太祐, 久保田芳明, 西野拓也, 岩出佳樹, 橘貴大, 渡邉将央, 松田淳也, 加藤活人, 太良修平, 時田祐吉, 宮地秀樹, 伊勢雄也, 岩崎雄樹, 浅井邦也

日本心臓病学会学術集会(Web) 71st 2023

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超高齢心不全患者における肥満パラドックス

橘貴大, 久保田芳明, 西野拓也, 岩出佳樹, 林太祐, 渡邉将央, 松田淳也, 加藤活人, 太良修平, 時田祐吉, 宮地秀樹, 岩崎雄樹, 浅井邦也

日本心臓病学会学術集会(Web) 71st 2023

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Percutaneous transluminal septal myocardial ablation in the multidisciplinary treatment of hypertrophic cardiomyopathy.

松田淳也

循環器内科 93 ( 6 ) 2023

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SYNTAX score,SYNTAX score IIの経時的変化と予後との関連

中村有希, 時田祐吉, 石原翔, 渡邉将央, 木村徳宏, 澁谷淳介, 塩村玲子, 松田淳也, 野間さつき, 久保田芳明, 中田淳, 宮地秀樹, 太良修平, 山本剛, 浅井邦也

日本心臓病学会学術集会(Web) 71st 2023

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心原性ショックを合併した急性心筋梗塞後の僧帽弁逆流に対する治療

石原翔, 中田淳, 高橋應仁, 蜂須賀誠人, 木村徳宏, 塩村玲子, 澁谷淳介, 宮地秀樹, 山本剛, 浅井邦也, 松田淳也

日本心臓病学会学術集会(Web) 71st 2023

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退院時看護必要度B項目が初発心不全患者の予後に与える影響

完山穂波, 久保田芳明, 大金美羽子, 背戸陽子, 西野卓也, 林太祐, 岩出佳樹, 加藤活人, 渡邉将央, 松田淳也, 太良修平, 時田祐吉, 宮地秀樹, 岩崎雄樹, 浅井邦也

日本心不全学会学術集会プログラム・抄録集 27th (CD-ROM) 2023

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最適な退院処方日数を心不全チームで考える

林太祐, 久保田芳明, 西野拓也, 完山穂波, 岩出佳樹, 橘貴大, 渡邉将央, 松田淳也, 加藤活人, 太良修平, 時田佑吉, 宮地秀樹, 伊勢雄也, 岩崎雄樹, 浅井邦也

日本心不全学会学術集会プログラム・抄録集 27th (CD-ROM) 2023

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心不全患者へのピモベンダン導入によるGDMT強化は再入院率の低下に寄与するか?

岩出佳樹, 久保田芳明, 林太祐, 西野拓也, 橘貴大, 渡邉将央, 松田淳也, 加藤活人, 太良修平, 宮地秀樹, 時田祐吉, 伊勢雄也, 岩崎雄樹, 浅井邦也

日本心不全学会学術集会プログラム・抄録集 27th (CD-ROM) 2023

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Relationship between Coronary Microvascular Dysfunction Evaluated by Dynamic Single-photon Emission Computed Tomography and Diastolic Dysfunction

田中匡成, 時田祐吉, 渡邉将央, 石原翔, 茂澤幸右, 星加優, 関俊樹, 福泉偉, 澁谷淳介, 塩村玲子, 野間さつき, 松田淳也, 久保田芳明, 中田淳, 宮地秀樹, 太良修平, 山本剛, 高野仁司, 今井祥吾, 桐山智成, 汲田伸一郎, 清水渉

日本循環器学会学術集会(Web) 87th 2023

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心不全患者の左室駆出率によってピモベンダンの効果に差異はあるか?

岩出佳樹, 林太祐, 久保田芳明, 西野拓也, 渡邉将央, 橘貴大, 松田淳也, 加藤活人, 太良修平, 宮地秀樹, 時田祐吉, 伊勢雄也, 岩崎雄樹, 浅井邦也

日本医療薬学会年会講演要旨集(Web) 33rd 2023

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心不全患者において退院処方日数と予約外受診は予後に影響を与えるか

林太祐, 久保田芳明, 岩出佳樹, 西野拓也, 橘貴大, 渡邉将央, 松田淳也, 加藤活人, 太良修平, 時田祐吉, 宮地秀樹, 伊勢雄也, 岩崎雄樹, 浅井邦也

日本医療薬学会年会講演要旨集(Web) 33rd 2023

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巨大左室内血栓の抗凝固療法中に上腸間膜動脈塞栓症を合併した1例

岡田泰司, 松田淳也, 澁谷淳介, 岡英一郎, 小山内悠介, 田中匡成, 石原翔, 星加優, 日野真彰, 塩村玲子, 中田淳, 宮地秀樹, 岩崎雄樹, 清水渉, 山本剛

ICUとCCU 46 ( 別冊 ) S80 - S80 2022.12

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80歳以上高齢者の急性心不全における院内死亡に関連するリスク因子の検討

塚本茂人, 新家俊郎, 原田和昌, 宮崎哲朗, 宮本貴庸, 香坂俊, 松下建一, 飯田圭, 武井眞, 松田淳也, 岩崎陽一, 山本良也, 進藤彰人, 竹村和紀, 木庭新治, 北野大輔, 白石泰之, 神馬栄宏, 長友祐司, 山本剛, 長山建, 高山守正, 東京都CCUネットワーク学術委員会

ICUとCCU 46 ( 別冊 ) S26 - S27 2022.12

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集中治療における重症心不全に対する補助循環によるブリッジ-VA-ECMO,ECPELLA,VAD- ECPELLAを用いた心原性ショック患者の予後改善への取り組み

中田淳, 田中匡成, 星加優, 日野真彰, 岡英一郎, 塩村玲子, 渋谷淳介, 松田淳也, 宮地秀樹, 山本剛, 清水渉

日本集中治療医学会雑誌 29 ( Suppl.1 ) 355 - 355 2022.11

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心不全患者に対する赤血球輸血とその後の心血管イベントの検討

渡邉将央, 太良修平, 西野拓也, 加藤活人, 久保田芳明, 林太祐, 茂澤幸右, 松田淳也, 時田祐吉, 伊勢雄也, 岩崎雄樹, 安武正弘, 清水渉

日本心臓病学会学術集会抄録 70回 O - 2 2022.9

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心不全症例におけるポリファーシーと転倒転落の関連性について

西野拓也, 久保田芳明, 林太祐, 渡邉将央, 太良修平, 加藤活人, 茂澤幸右, 松田淳也, 時田祐吉, 伊勢雄也, 岩崎雄樹, 安武正弘, 清水渉

日本心臓病学会学術集会抄録 70回 O - 4 2022.9

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心原性ショックを伴う重症大動脈弁狭窄症に対する集学的カテーテル治療の1例

星加優, 中田淳, 浅見慎思, 田中匡成, 日野真彰, 岡英一郎, 塩村玲子, 澁谷淳介, 松田淳也, 宮地秀樹, 清水渉, 山本剛, 高野仁司

日本心血管インターベンション治療学会抄録集 30回 [MO047] - [MO047] 2022.7

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血栓症リスクが経皮的冠動脈インターベンション1年後のステント内血管内視鏡所見に及ぼす影響

橘貴大, 時田祐吉, 小山賢太郎, 田中匡成, 茂澤幸右, 星加優, 関俊樹, 福泉偉, 澁谷淳介, 塩村玲子, 松田淳也, 野間さつき, 久保田芳明, 中田淳, 宮地秀樹, 太良修平, 山本剛, 清水渉, 高野仁司

日本心血管インターベンション治療学会抄録集 30回 [MO206] - [MO206] 2022.7

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Impella抜去後に急性下肢動脈閉塞を呈し、Fogartyカテーテルの使用と血管内治療のハイブリッド治療で良好な血流を得た78歳男性

澁谷淳介, 田中匡成, 星加優, 岡英一郎, 塩村玲子, 松田淳也, 中田淳, 宮地秀樹, 岩崎雄樹, 清水渉, 山本剛

日本心血管インターベンション治療学会抄録集 30回 [MO490] - [MO490] 2022.7

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閉塞性肥大型心筋症に対する経皮的中隔心筋焼灼術後の完全房室ブロックへの恒久的ペースメーカ植え込み時期に関する検討

小山賢太郎, 松田淳也, 橘貴大, 田中匡成, 茂澤幸右, 星加優, 関俊樹, 福泉偉, 澁谷淳介, 塩村玲子, 野間さつき, 久保田芳明, 井守洋一, 中田淳, 宮地秀樹, 太良修平, 時田祐吉, 山本剛, 清水渉, 高野仁司

日本心血管インターベンション治療学会抄録集 30回 [MO269] - [MO269] 2022.7

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Minimum Serum Albumin Levels in Cardiovascular Intensive Care Unit are Associated with In-hospital Mortality in Patients with Acute Heart Failure(和訳中)

石原翔, 宮地秀樹, 小山内悠介, 星加優, 日野真彰, 岡英一郎, 塩村玲子, 澁谷淳介, 松田淳也, 中田淳, 清水渉, 山本剛

日本循環器学会学術集会抄録集 86回 PJ48 - 6 2022.3

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ICU適応基準を用いて評価したCCU患者の患者背景と転帰(Demographics and Outcomes of CCU Patients Evaluated by Applying ICU Indication Criteria)

松田淳也, 石原翔, 星加優, 日野真彰, 岡英一郎, 澁谷淳介, 塩村玲子, 中田淳, 宮地秀樹, 岩崎雄樹, 清水渉, 山本剛

日本循環器学会学術集会抄録集 86回 PJ10 - 1 2022.3

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心臓リハビリテーション施行患者における最大歩行速度と無酸素性作業閾値の関連(Relationship between Maximum Walking Speed and Anearobic Threshold in Patients Undergoing Cardiac Rehabilitation)

Koen Masahiro, Takano Hitoshi, Wakita Masaki, Onodera Kenta, Matsuda Junya, Tokita Miwa, Katoh Kazuyo, Takahashi Hiroshi, Akutsu Koichi, Shimizu Wataru

日本循環器学会学術集会抄録集 86回 PE19 - 6 2022.3

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Demographics and Outcomes of CCU Patients Evaluated by Applying ICU Indication Criteria(和訳中)

松田淳也, 石原翔, 星加優, 日野真彰, 岡英一郎, 澁谷淳介, 塩村玲子, 中田淳, 宮地秀樹, 岩崎雄樹, 清水渉, 山本剛

日本循環器学会学術集会抄録集 86回 PJ10 - 1 2022.3

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冠微小循環の最適診断法定量的な心筋血流画像により評価した冠微小血管障害と拡張機能障害の関連(Relationship between Coronary Microvascular Dysfunction Evaluated by Quantitative Myocardial Perfusion Imagings and Diastolic Dysfunction)

野間さつき, 時田祐吉, 田中匡成, 石原翔, 茂澤幸右, 星加優, 関俊樹, 福泉偉, 澁谷淳介, 塩村玲子, 松田淳也, 久保田芳明, 中田淳, 宮地秀樹, 太良修平, 山本剛, 高野仁司, 今井祥吾, 桐山智成, 汲田伸一郎, 清水渉

日本循環器学会学術集会抄録集 86回 SY08 - 4 2022.3

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冠微小循環の最適診断法(Relationship between Coronary Microvascular Dysfunction Evaluated by Quantitative Myocardial Perfusion Imagings and Diastolic Dysfunction)

野間さつき, 時田祐吉, 田中匡成, 石原翔, 茂澤幸右, 星加優, 関俊樹, 福泉偉, 澁谷淳介, 塩村玲子, 松田淳也, 久保田芳明, 中田淳, 宮地秀樹, 太良修平, 山本剛, 高野仁司, 今井祥吾, 桐山智成, 汲田伸一郎, 清水渉

日本循環器学会学術集会抄録集 86回 SY08 - 4 2022.3

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心原性ショックを伴うAMIに対するImpella-assisted CABG:CHIP症例を含めた検討

丸山雄二, 中田淳, 前田基博, 村田智洋, 太田恵介, 上田仁美, 森嶋素子, 栗田二郎, 佐々木孝, 宮城泰雄, 松田淳也, 宮地秀樹, 山本剛, 石井庸介

日本心臓血管外科学会学術総会(Web) 52nd 2022

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がん患者の呼吸困難に対する薬物療法~システマティックレビューから見えてきたもの~

山口崇, 松田能宣, 渡邊紘章, 森雅紀, 小原弘之, 山本泰大, 高木雄亮, 松沼亮, 佐藤淳也, 安田俊太郎, 菅野康二, 片山英樹, 鈴木梢

日本がんサポーティブケア学会学術集会プログラム・抄録集(CD-ROM) 7th (Web) 2022

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大気汚染が心不全入院に及ぼす影響

武井眞, 原田和昌, 白石泰之, 松田淳也, 岩崎陽一, 山本良也, 松下健一, 宮崎哲朗, 宮本貴庸, 飯田圭, 谷本周三, 長友祐司, 細田徹, 香坂俊, 山本剛, 長尾建, 高山守正, 東京都CCUネットワーク学術委員会

ICUとCCU 45 ( 別冊 ) S43 - S45 2021.12

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序論:PM2.5をはじめとした大気汚染物質と心不全入院の関連が従来報告されてきた。しかしながら、こうした研究は主に疫学的なデータを背景としており、心不全患者それぞれの患者背景により大気汚染物質への感受性が異なるかどうかについての報告はなされていない。本研究ではPM2.5の濃度が心不全入院率に及ぼす影響について、患者背景を含めて解析した。方法:2017年に東京都CCUネットワーク心不全レジストリに登録された4,980例を解析した。Case cross over解析、Logistic regression解析を用いてPM2.5の大気中の濃度が1μg/m3上昇するごとに心不全入院率が何%上昇するかを全症例および事前に設定したサブグループについて検討した。結果:PM2.5濃度が1μg/m3上昇するに従い心不全入院率は2.9%(95%信頼区間1.2〜4.6%)上昇した。サブグループ解析においては75歳以下、心不全入院歴のない症例、高血圧既往のない症例、貧血のない症例、左室機能の低下した心不全においてPM2.5に対する感受性の上昇が示唆された。結論:PM2.5の上昇は心不全入院率の上昇と関連しており、特定の患者背景を持つ症例においてとくに感受性が高い可能性が示唆された。(著者抄録)

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超高齢者(90歳以上)の急性心不全の臨床像の特徴

塚本茂人, 新家俊郎, 原田和昌, 宮崎哲朗, 宮本貴庸, 香坂俊, 松下建一, 飯田圭, 武井眞, 松田淳也, 岩崎陽一, 山本良也, 進藤彰人, 竹村和紀, 木庭新治, 北野大輔, 白石泰之, 神馬栄宏, 長友祐司, 山本剛, 長尾建, 高山守正, 東京都CCUネットワーク学術委員会

ICUとCCU 45 ( 別冊 ) S41 - S42 2021.12

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救急搬送を要した心不全再入院患者における受療遅延とその臨床病型との関連

武井眞, 原田和昌, 白石泰之, 松田淳也, 岩崎陽一, 山本良也, 松下健一, 宮崎哲朗, 宮本貴庸, 飯田圭, 谷本周三, 長友祐司, 細田徹, 香坂俊, 山本剛, 長尾建, 高山守正

ICUとCCU 45 ( 別冊 ) S33 - S33 2021.12

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O-3.3枝病変を有する心原性ショックに対し、IMPELLA補助下で内科的治療を優先し、待機的に外科的完全血行再建を行い良好な経過が得られた1例

茂澤幸右, 松田淳也, 塩村玲子, 丸山雄二, 山田健太, 岡英一郎, 杉崎陽一郎, 中田淳, 宮地秀樹, 太良修平, 山本剛, 高野仁司, 石井庸介, 清水渉

ICUとCCU 45 ( 別冊 ) S56 - S56 2021.12

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超高齢者(90歳以上)の急性心不全の臨床像の特徴

塚本茂人, 新家俊郎, 原田和昌, 宮崎哲朗, 宮本貴庸, 香坂俊, 松下建一, 飯田圭, 武井眞, 松田淳也, 岩崎陽一, 山本良也, 進藤彰人, 竹村和紀, 木庭新治, 北野大輔, 白石泰之, 神馬栄宏, 長友祐司, 山本剛, 長尾建, 高山守正, 東京都CCUネットワーク学術委員会

ICUとCCU 45 ( 別冊 ) S41 - S42 2021.12

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【最新主要文献とガイドラインでみる循環器内科学レビュー2022-'23】(V章)原発性心筋症・心筋炎・心膜疾患・心臓腫瘍肥大型心筋症における最新の話題

松田淳也

循環器内科学レビュー 2022-'23 209 - 220 2021.11

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急性B型大動脈解離の治療戦略急性B型大動脈解離における挿管を要する重症呼吸不全の原因は何か?

圷宏一, 山本剛, 中田淳, 松田淳也, 塩村玲子, 岡英一郎, 宮地秀樹, 太良修平, 栗田二郎, 丸山雄二, 石井庸介, 清水渉

脈管学 61 ( Suppl. ) S129 - S129 2021.10

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心原性ショック管理への挑戦心原性ショックに対するチーム管理の重要性

山本剛, 岡英一郎, 塩村玲子, 松田淳也, 中田淳, 宮地秀樹, 太良修平, 時田祐吉, 圷宏一, 清水渉

日本集中治療医学会雑誌 28 ( Suppl.2 ) 216 - 216 2021.9

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肥大型心筋症における左室収縮能低下の予測スコア

石原翔, 久保田芳明, 松田淳也, 井守洋一, 時田祐吉, 高野仁司, 清水渉

日本心臓病学会学術集会抄録 69回 O - 224 2021.9

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心原性ショック合併急性心筋梗塞に対して血行再建前のImpella導入により再灌流が得られた1例

杉崎陽一郎, 中田淳, 山本剛, 太良修平, 松田淳也, 塩村玲子, 岡英一郎, 清水渉

日本集中治療医学会雑誌 28 ( Suppl.2 ) 405 - 405 2021.9

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アルコール中隔心筋焼灼術によるLV流出路狭窄の著明改善後も症状が持続する要因(Factors Affecting the Persistent Symptoms Even after the Significant Attenuation of LV Outflow Obstruction by Alcohol Septal Ablation)

諸岡雅城, 高野仁司, 井守洋一, 松田淳也, 時田祐吉, 福泉偉, 野間さつき, 久保田芳明, 太良修平, 宮地秀樹, 山本剛, 清水渉

日本循環器学会学術集会抄録集 85回 OJ28 - 8 2021.3

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集学的な"Shock Team"におけるSCAI心原性ショック分類を用いた心筋梗塞による心原性ショックに対するチーム医療の定型化(Standardized Team-based Care for Cardiogenic Shock Concomitant with Myocardial Infarction Using SCAI Shock Classification in Multidisciplinary "Shock Team")

中田淳, 山田健太, 茂澤幸右, 塩村玲子, 杉崎陽一郎, 松田淳也, 宮地秀樹, 山本剛, 高野仁司, 増野智彦, 横堀將司, 清水渉

日本循環器学会学術集会抄録集 85回 SS13 - 4 2021.3

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冠動脈疾患患者における13N-アンモニアPETで評価した冠微小血管機能障害と拡張機能障害との関連(Relationship between Coronary Microvascular Dysfunction Evaluated by 13N-ammonia Positron Emission Tomography and Diastolic Dysfunction in Patients with Coronary Artery Disease)

野間さつき, 時田祐吉, 石原翔, 茂澤幸右, 星加優, 関俊樹, 笹本希, 福泉偉, 塩村玲子, 松田淳也, 久保田芳明, 中田淳, 宮地秀樹, 太良修平, 山本剛, 高野仁司, 今井祥吾, 桐山智成, 汲田伸一郎, 清水渉

日本循環器学会学術集会抄録集 85回 OJ75 - 3 2021.3

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心原性ショックを合併した急性心筋梗塞における早期乳酸値とSOFAスコアによる生存率の予測(Early Lactate Level and SOFA Score Predict Survival in Cardiogenic Shock Complicating Acute Myocardial Infarction)

塩村玲子, 中田淳, 山本剛, 山田健太, 茂沢幸佑, 岡英一郎, 杉崎陽一郎, 門岡浩介, 松田淳也, 三軒豪仁, 宮地秀樹, 太良修平, 高野仁司, 清水渉

日本循環器学会学術集会抄録集 85回 OJ31 - 4 2021.3

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Standardized Team-based Care for Cardiogenic Shock Concomitant with Myocardial Infarction Using SCAI Shock Classification in Multidisciplinary "Shock Team"(和訳中)

中田淳, 山田健太, 茂澤幸右, 塩村玲子, 杉崎陽一郎, 松田淳也, 宮地秀樹, 山本剛, 高野仁司, 増野智彦, 横堀將司, 清水渉

日本循環器学会学術集会抄録集 85回 SS13 - 4 2021.3

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Factors Affecting the Persistent Symptoms Even after the Significant Attenuation of LV Outflow Obstruction by Alcohol Septal Ablation(和訳中)

諸岡雅城, 高野仁司, 井守洋一, 松田淳也, 時田祐吉, 福泉偉, 野間さつき, 久保田芳明, 太良修平, 宮地秀樹, 山本剛, 清水渉

日本循環器学会学術集会抄録集 85回 OJ28 - 8 2021.3

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Factors that Predict Cases of Improved Cardiac Function in the Clinical Course of Fulminant Myocarditis(和訳中)

岡英一郎, 中田淳, 茂澤幸右, 山田健太, 杉崎陽一郎, 塩村玲子, 松田淳也, 宮地秀樹, 太良修平, 岩崎雄樹, 山本剛, 清水渉

日本循環器学会学術集会抄録集 85回 OJ67 - 5 2021.3

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Relationship between Coronary Microvascular Dysfunction Evaluated by 13N-ammonia Positron Emission Tomography and Diastolic Dysfunction in Patients with Coronary Artery Disease(和訳中)

野間さつき, 時田祐吉, 石原翔, 茂澤幸右, 星加優, 関俊樹, 笹本希, 福泉偉, 塩村玲子, 松田淳也, 久保田芳明, 中田淳, 宮地秀樹, 太良修平, 山本剛, 高野仁司, 今井祥吾, 桐山智成, 汲田伸一郎, 清水渉

日本循環器学会学術集会抄録集 85回 OJ75 - 3 2021.3

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Clinical Feature and Long-term Prognosis of Tolvaptan in the Patients with Congestive Heart Failure: A Comparison between HFpEF and HFrEF(和訳中)

関俊樹, 久保田芳明, 松田淳也, 時田祐吉, 岩崎雄樹, 清水渉

日本循環器学会学術集会抄録集 85回 OJ63 - 2 2021.3

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有効なPTSMA治療後に症状改善に至らなかった規定因子の解析

諸岡雅城, 高野仁司, 井守洋一, 松田淳也, 時田祐吉, 福泉偉, 野間さつき, 久保田芳明, 中田淳, 宮地秀樹, 太良修平, 山本剛, 清水渉

日本心血管インターベンション治療学会抄録集 29回 1047 - 1047 2021.2

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心臓カテーテル検査を受けた高齢認知症患者の臨床経過と傾向について

茂澤幸右, 高野仁司, 久保田芳明, 塩村玲子, 福泉偉, 松田淳也, 野間さつき, 井守洋一, 西城由之, 中田淳, 宮地秀樹, 太良修平, 時田祐吉, 山本剛, 清水渉

日本心血管インターベンション治療学会抄録集 29回 578 - 578 2021.2

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心臓カテーテル検査を受けた高齢認知症患者の臨床経過と傾向について

茂澤幸右, 高野仁司, 久保田芳明, 塩村玲子, 福泉偉, 松田淳也, 野間さつき, 井守洋一, 西城由之, 中田淳, 宮地秀樹, 太良修平, 時田祐吉, 山本剛, 清水渉

日本心血管インターベンション治療学会抄録集 29回 578 - 578 2021.2

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アルコール中隔心筋焼灼術後に房室解離を伴う心原性ショックを合併した閉塞性肥大型心筋症に対するImpellaの使用(Impella use in patient with hypertrophic obstructive cardiomyopathy complicated by cardiogenic shock associated with atrioventricular disconnection after alcohol septal ablation)

松田淳也, 高野仁司, 井守洋一, 時田祐吉, 諸岡雅城, 塩村玲子, 福泉偉, 野間さつき, 久保田芳明, 小宮山英徳, 中田淳, 宮地秀樹, 太良修平, 山本剛, 清水渉

日本心血管インターベンション治療学会抄録集 29回 1382 - 1382 2021.2

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虚血性心疾患治療に補助循環をどのように活用するか補助循環装置を用いたAMI心原性ショック治療ショックチームの視点から

中田淳, 小林典之, 藤本雄飛, 塩村玲子, 松田淳也, 三軒豪仁, 西城由之, 細川雄亮, 太良修平, 山本剛, 高野仁司, 清水渉

日本心血管インターベンション治療学会抄録集 29回 443 - 443 2021.2

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PCI innovation PCIにおけるImpella補助循環用ポンプカテーテルの有用性

中田淳, 小林典之, 藤本雄飛, 塩村玲子, 松田淳也, 三軒豪仁, 西城由之, 細川雄亮, 太良修平, 山本剛, 高野仁司, 清水渉

日本心血管インターベンション治療学会抄録集 29回 349 - 349 2021.2

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ショックチームプロトコルを用いた心原性ショック治療

中田淳, 山本剛, 茂澤幸右, 山田健太, 岡英一郎, 塩村玲子, 杉崎陽一郎, 松田淳也, 宮地秀樹, 清水渉

日本集中治療医学会学術集会(Web) 48th 2021

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本邦におけるCOVID-19パンデミックがST上昇型心筋梗塞患者に与える影響

渡邉将央, 宮地秀樹, 茂澤幸右, 山田健太, 岡英一郎, 塩村玲子, 杉崎陽一郎, 松田淳也, 中田淳, 山本剛, 岩崎雄樹, 高野仁司, 清水渉

日本心臓病学会学術集会(Web) 69th 2021

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冠動脈ステント留置1年後の血管内視鏡所見とステント血栓症リスク因子の関連についての検討

福泉偉, 時田祐吉, 塩村玲子, 塩村玲子, 澁谷淳介, 澁谷淳介, 松田淳也, 松田淳也, 野間さつき, 久保田芳明, 中田淳, 中田淳, 宮地秀樹, 宮地秀樹, 太良修平, 高野仁司, 清水渉

日本冠疾患学会誌(Web) ( Supplement ) 2021

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ショックチームプロトコルに基づいたAMI心原性ショック治療

中田淳, 田中匡成, 星加優, 日野真彰, 岡英一郎, 塩村玲子, 渋谷淳介, 松田淳也, 宮地秀樹, 山本剛, 清水渉

日本冠疾患学会誌(Web) ( Supplement ) 2021

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超高齢者(90歳以上)の急性心不全の臨床像の特徴

塚本茂人, 新家俊郎, 原田和昌, 宮崎哲朗, 宮本貴庸, 香坂俊, 松下健一, 飯田圭, 武井眞, 松田淳也, 岩崎陽一, 山本良也, 進藤彰人, 竹村和紀, 木庭新治, 北野大輔, 白石泰之, 神馬崇宏, 長友祐司, 山本剛, 長尾建, 高山守正, 東京都CCUネットワーク学術委員会

ICUとCCU 44 ( 別冊 ) S110 - S113 2020.12

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背景:日本は超高齢社会へと突入し、高齢者と超高齢者を中心に心不全の増加が顕著である。多くの疫学データや臨床データは比較的若年者の心不全を対象としており、高齢者および超高齢者の心不全におけるデータは限られている。目的:超高齢者の急性心不全の特徴を明らかにする。方法:2016年1月から12月までの1年間に急性心不全で東京都CCUネットワーク登録施設に登録された5,045例の患者を対象とした。これらを90歳以上の超高齢者、75歳から89歳までの高齢者、65歳から74歳までの準高齢者、65歳未満の4群に分類し、それらの臨床データを比較検討した。結果:超高齢者の心不全は左室駆出率が保たれたHFpEFが多く、これらは弁膜症による心不全が多いことに起因するものと考えられた。ACE阻害薬およびARB、β遮断薬の処方率は超高齢者ではいずれも50%を下回っており、超高齢者の心不全における薬物療法の難しさが見て取れた。超高齢者の心不全は、若年心不全の延長ではなかった。超高齢者は院内死亡率が高く、他の年齢区分と比較しても予後不良であった。(著者抄録)

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外来患者の利尿薬の中止は、心不全の代償性の時期に考慮されるべきである

宮本貴庸, 原田和昌, 宮崎哲朗, 香坂俊, 飯田圭, 矢川真弓子, 松下健一, 武井眞, 松田淳也, 岩崎陽一, 長友祐司, 細田徹, 白石泰之, 山本剛, 長尾建, 高山守正, 東京都CCUネットワーク学術委員会心不全班

ICUとCCU 44 ( 別冊 ) S109 - S109 2020.12

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再発した急性冠症候群患者の特徴と二次予防

太良修平, 石原翔, 山田健太, 岡英一郎, 杉崎陽一郎, 塩村玲子, 松田淳也, 中田淳, 山本剛, 清水渉

脈管学 60 ( Suppl. ) S128 - S129 2020.10

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亜急性心筋梗塞の予後は良好か?

細川雄亮, 山本剛, 松田淳也, 三軒豪仁, 中田淳, 宮地秀樹, 太良修平, 時田祐吉, 宗像亮, 清水渉

日本集中治療医学会雑誌 27 ( Suppl. ) 474 - 474 2020.9

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【循環器疾患と臨床検査】急性冠症候群の心電図

松田淳也, 清水渉

アニムス 25 ( 3 ) 10 - 18 2020.7

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緊急心血管疾患患者におけるCCU滞在時の消化管出血とその後の心血管イベントとの関連(Association between Gastrointestinal Bleeding during CCU Stay and Subsequent Cardiovascular Events in Patients with Emergency Cardiovascular Diseases)

Sakai Shin, Tara Shuhei, Fujimoto Yuhi, Shiomura Reiko, Matsuda Junya, Saiki Yoshiyuki, Nakata Jun, Hosokawa Yusuke, Yamamoto Takeshi, Shimizu Wataru

日本循環器学会学術集会抄録集 84回 OE60 - 5 2020.7

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Impellaを用いた心原性ショック患者の予後改善への取り組み

中田淳, 藤本雄飛, 塩村玲子, 松田淳也, 三軒豪仁, 西城由之, 太良修平, 山本剛, 高野仁司, 清水渉, 清水渉

日本集中治療医学会学術集会(Web) 47th 2020

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経皮的中隔心筋焼灼術後の敗血症および心原性ショックに対しImpella補助が有用であった閉塞性肥大型心筋症の1例

松田淳也, 中田淳, 山本剛, 小林典之, 脇田真希, 藤本雄飛, 塩村玲子, 西城由之, 太良修平, 高野仁司, 清水渉

ICUとCCU 44 2020

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ICUにおけるImpella関連合併症の検討

塩村玲子, 中田淳, 小林典之, 藤本雄飛, 松田淳也, 三軒豪仁, 西城由之, 太良修平, 山本剛, 清水渉, 清水渉

日本集中治療医学会学術集会(Web) 47th 2020

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機械的補助循環を用いたAMI-CS治療

中田淳, 山本剛, 杉崎陽一郎, 岡英一郎, 山田健太, 橘貴大, 松田淳也, 塩村玲子, 茂澤幸右, 田中匡成, 宮地秀樹, 清水渉

日本心不全学会学術集会プログラム・抄録集 24th (CD-ROM) 2020

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救急搬送を要した心不全再入院患者における受療遅延 CCUネットワークデータベースからの解析

武井眞, 原田和昌, 白石泰之, 香坂俊, 宮崎哲朗, 宮本貴庸, 飯田圭, 谷本周三, 矢川真弓子, 松下健一, 松田淳也, 岩崎陽一, 長友祐司, 細田徹, 山本剛, 長尾建, 高橋寿由樹, 高山守正, 東京都CCUネットワーク学術委員会

ICUとCCU 43 ( 別冊 ) S108 - S109 2019.12

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Lag Effect of Temperature and Atmospheric Pressure Affects the Incidents and the Manner of Acute Heart Failure

Takahiro Jimba, Masao Yamasaki, Akito Shindo, Kazunori Takemura, Youichi Iwasaki, Junya Matsuda, Yoshiya Yamamoto, Makoto Takei, Daisuke Kitano, Yasuyuki Shiraishi, Shigeto Tsukamoto, Shun Kohsaka, Yuji Nagatomo, Tetsuro Miyazaki, Kenichi Matsushita, Takamichi Miyamoto, Kiyoshi Iida, Shinji Koba, Toshiaki Otsuka, Kazumasa Harada, Takeshi Yamamoto, Ken Nagao, Morimasa Takayama

CIRCULATION 140 2019.11

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4D Flow MRI撮像の際に取得したmagnitude imagingのdephasingを利用した乱流運動エネルギー測定閉塞性肥大型心筋症患者における臨床応用

岩田琴美, 関根鉄朗, 安藤嵩浩, 汲田伸一郎, 井守洋一, 松田淳也, 高野仁司

日本医科大学医学会雑誌 15 ( 4 ) 258 - 259 2019.10

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心不全を有する超高齢者患者(90歳以上)の臨床像の特徴(The Characteristics of Clinical Picture for Superelderly Patients (Over 90 Years Old) with Heart Failure)

塚本茂人, 新家俊郎, 原田和昌, 宮崎哲朗, 宮本貴庸, 香坂俊, 松下健一, 飯田圭, 武井眞, 松田淳也, 岩崎陽一, 山本良也, 進藤彰人, 竹村和紀, 木庭新治, 白石泰之, 長友祐司, 神馬崇宏, 山本剛, 長尾建, 高山守正, 東京都CCUネットワーク学術委員会

日本循環器学会学術集会抄録集 83回 PJ095 - 1 2019.3

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【Point-of-Care超音波-basicからadvanced skillまで-】Q&A トピックス編たこつぼ心筋症

松田淳也, 山本剛

救急・集中治療 31 ( 1 ) 195 - 204 2019.2

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＜point＞▼たこつぼ心筋症の典型的な壁運動異常は、心尖部の無収縮と心基部の過収縮を示す。▼典型的な心尖部型が全体の8割、残りが心室中部や心基部に無収縮を示す亜型である。▼たこつぼ心筋症の壁運動異常は、冠動脈支配に一致しない。▼急性期合併症として、心不全、左室流出路狭窄、僧帽弁逆流、心内血栓、心破裂がある。▼敗血症性心筋症では、可逆性のびまん性壁運動異常をきたす。(著者抄録)

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急性心不全患者の死亡率予測における乳酸値の有用性

松田淳也, 久保田芳明, 泉祐樹, 藤本竜平, 三軒豪仁, 中田淳, 細川雄亮, 太良修平, 山本剛, 清水渉

日本集中治療医学会雑誌 26 ( Suppl. ) [O88 - 1] 2019.2

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心タンポナーデによる閉塞性ショックから重度の低酸素性肝炎を呈した心筋梗塞後左室自由壁破裂の一例

藤本竜平, 松田淳也, 細川雄亮, 中田淳, 三軒豪仁, 浅野和弘, 木村徳宏, 太良修平, 山本剛, 清水渉

日本救急医学会関東地方会雑誌(Web) 40 ( 1 ) 2019

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入院前投与薬剤は、急性心不全の来院時呼吸状態と院内死亡率に影響を与える

宮本貴庸, 原田和昌, 宮崎哲郎, 香坂俊, 飯田圭, 谷本周三, 矢川真弓子, 松下健一, 武井眞, 松田淳也, 岩崎陽一, 長友祐司, 細田徹, 白石泰之, 山本剛, 長尾建, 高山守正

ICUとCCU 42 ( 別冊 ) S79 - S81 2018.12

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4D flow MRIを用いた閉塞性肥大型心筋症に対する経皮的中隔心筋焼灼術前後の血流解析

松田淳也, 高野仁司, 関根鉄郎, 井守洋一, 時田祐吉, 三軒豪仁, 久保田芳明, 中田淳, 宮地秀樹, 太良修平, 細川雄亮, 山本剛, 高木元, 清水渉

日本心臓病学会学術集会抄録 66回 O - 090 2018.9

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4D flow MRIを用いた閉塞性肥大型心筋症における乱流エネルギーの定量に関する検討

岩田琴美, 関根鉄朗, 城正樹, 井守洋一, 松田淳也, 武田美那子, 天野康雄, 新田武史, 小原真, 汲田伸一郎

日本医学放射線学会秋季臨床大会抄録集 54回 S451 - S452 2018.9

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閉塞性肥大型心筋症の左室内収縮期圧較差測定穿刺部シース圧で代用した大動脈圧測定による患者負担の軽減

小林涼, 高野仁司, 井守洋一, 松田淳也, 三軒豪仁, 鈴木健一, 市場晋吾, 清水渉

日本心血管インターベンション治療学会抄録集 27回 CO060 - CO060 2018.8

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閉塞性肥大型心筋症に対するASA後の右脚ブロックと1年予後の関連性

松田淳也, 高野仁司, 井守洋一, 時田祐吉, 三軒豪仁, 野間さつき, 高圓雅博, 中村有希, 久保田芳明, 中田淳, 宮地秀樹, 太良修平, 細川雄亮, 山本剛, 高木元, 浅井邦也, 清水渉

日本心血管インターベンション治療学会抄録集 27回 MO063 - MO063 2018.8

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薬剤抵抗性閉塞性肥大型心筋症に対してパーフュージョンバルーンとマイクロカテーテルを用い経皮的中隔心筋焼灼術を行い得た一例

松田淳也, 高野仁司, 井守洋一, 時田祐吉, 三軒豪仁, 野間さつき, 高圓雅博, 中村有希, 久保田芳明, 中田淳, 宮地秀樹, 太良修平, 細川雄亮, 山本剛, 高木元, 浅井邦也, 清水渉

日本心血管インターベンション治療学会抄録集 27回 MO062 - MO062 2018.8

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【ER、ICUのための循環器疾患の見方、考え方-エキスパートの診断テクニック-】浮腫収縮性心膜炎(慢性の急性増悪も含む)

松田淳也

救急・集中治療 30 ( 2 ) 276 - 280 2018.3

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＜Point＞▼全身倦怠感や息切れといった右心不全を主体とする疾患である。▼心膜の肥厚・石灰化を伴わない症例が約20%認められ、機能的な診断が重要である。(著者抄録)

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【ER、ICUのための循環器疾患の見方、考え方-エキスパートの診断テクニック-】発熱(感染症) 感染性心内膜炎

松田淳也

救急・集中治療 30 ( 2 ) 249 - 255 2018.3

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＜Point＞▼原因不明の発熱が持続する場合は、感染性心内膜炎を疑い全身を隈なく検索する。▼確定診断には複数回の血液培養検査と心臓超音波検査が必要である。(著者抄録)

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4D flow MRIを用いた閉塞性肥大型心筋症に対する経皮的中隔心筋焼灼術前後の血流解析

松田淳也, 高野仁司, 関根鉄郎, 井守洋一, 時田祐吉, 三軒豪仁, 久保田芳明, 中田淳, 宮地秀樹, 太良修平, 細川雄亮, 山本剛, 高木元, 清水渉

日本心臓病学会学術集会(Web) 66th ROMBUNNO.O‐090 (WEB ONLY) - 090 2018

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閉塞性肥大型心筋症の非心臓手術周術期管理における経皮吸収型β₁遮断薬の有用性

井守洋一, 高野仁司, 間瀬大司, 松田淳也, 三軒豪仁, 時田祐吉, 清水渉

日本心臓病学会学術集会(Web) 66th ROMBUNNO.O‐091 (WEB ONLY) - 091 2018

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左主幹部入口部病変に対するステント位置決めにFiltrapが有用であった一例

松田淳也, 高橋保裕, 塩村玲子, 福泉偉, 佐藤太亮, 清水渉

日本心血管インターベンション治療学会抄録集 26回 YI2 - 5 2017.7

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Successful Trans-collateral Approach for Chronic Total Occlusion of the Superficial Femoral Artery Using a Side-hole Sheath

Yasuhiro Takahashi, Reiko Shiomura, Erito Furuse, Junya Matsuda, Taisuke Sato, Wataru Shimizu

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 69 ( 16 ) S329 - S331 2017.4

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Successful Endovascular Treatment of Chronic Total Superficial Femoral Artery Occlusion Using a Side-hole Sheath and Re-entry Catheter

Reiko Shiomura, Yasuhiro Takahashi, Erito Furuse, Junya Matsuda, Taisuke Sato, Wataru Shimizu

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 69 ( 16 ) S300 - S301 2017.4

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A Case of Successful Treatment of Gamma Globulin Therapy in Patient With Drug Refractory Ventricular Fibrillation Associated With Fulminant Myocarditis

Junya Matsuda, Yasuhiro Takahashi, Taisuke Satou, Erito Furuse, Reiko Shiomura, Wataru Shimizu

JOURNAL OF CARDIAC FAILURE 22 ( 9 ) S220 - S220 2016.9

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診断に苦慮した冠攣縮による急性心筋梗塞の一例

松田淳也, 福泉偉, 羽田朋人, 佐藤太亮, 高橋保裕, 清水渉

日本心臓病学会学術集会抄録 64回 P - 262 2016.9

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急性心筋梗塞に対するPCI中の急性ステント内血栓症に対するパーフュージョンバルーンの有用性

松田淳也, 高橋保裕, 福泉偉, 羽田朋人, 佐藤太亮, 清水渉

日本集中治療医学会雑誌 23 ( Suppl. ) 577 - 577 2016.1

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診断に苦慮した冠攣縮による急性心筋梗塞の一例

松田淳也, 福泉偉, 羽田朋人, 佐藤太亮, 高橋保裕, 清水渉

日本心臓病学会学術集会(Web) 64th ROMBUNNO.P‐262 (WEB ONLY) - 262 2016

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Successful Percutaneous Fogarty Balloon Catheter Embolectomy in a Centenarian Patient with Subacute Limb Ischemia

Tomohito Hada, Yasuhiro Takahashi, Junya Matsuda, Ko Toshinori, Taisuke Sato, Wataru Shimizu

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 65 ( 17 ) S362 - S363 2015.5

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NPPVが行われる場面を見てみよう!5 心原性肺水腫

松田淳也, 山本剛, 竹田晋浩

呼吸器ケア 92 - 95 2014.12

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【この一冊でズバリ知りたい!とことん理解!NPPVまるごとブック】(第3章)NPPVが行われる場面を見てみよう! 心原性肺水腫

松田淳也, 山本剛, 竹田晋浩

呼吸器ケア ( 2014冬季増刊 ) 92 - 95 2014.12

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Clinical Predictors for Repeat Alcohol Septal Ablation in Refractory Hypertrophic Obstructive Cardiomyopathy

Mitsunobu Kitamura, Morimasa Takayama, Yasuo Amano, Junsuke Shibuya, Junya Matsuda, Aya Yoshinaga, Syunichi Nakamura, Kuniya Asai, Hitoshi Takano, Wataru Shimizu

CIRCULATION 130 2014.11

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Clinical characteristics and cardiac magnetic resonance for the patients received repeat percutaneous transluminal septal myocardial ablation in refractory hypertrophic obstructive cardiomyopathy

M. Kitamura, Y. Amano, J. Shibuya, J. Matsuda, S. Nakamura, H. Takano, K. Asai, M. Takayama, W. Shimizu

EUROPEAN HEART JOURNAL 35 1084 - 1084 2014.9

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Feasibitily of Alcohol Septal Ablation Using Nitroglycerin Tests for Refractory Hypertrophic Obstructive Cardiomyopaty with Labile Obstruction

KITAMURA Mitsunobu, TAKAYAMA Morimasa, SHIBUYA Junsuke, MATSUDA Junya, SHIBATA Yusaku, KUBOTA Yoshiaki, NAKAMURA Shunichi, TAKANO Hitoshi, ASAI Kuniya, SHIMIZU Wataru

Circulation Journal 78 ( Supplement 1(CD-ROM) ) 2014

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Feasibility of Alcohol Septal Ablation Using Nitroglycerine Tests for Refractory Hypertrophic Obstructive Cardiomyopathy With Labile Gradient

Mitsunobu Kitamura, Morimasa Takayama, Junya Matsuda, Hidenori Komiyama, Yoshiaki Kubota, Syunichi Nakamura, Hitoshi Takano, Kuniya Asai, Wataru Shimizu

CIRCULATION 128 ( 22 ) 2013.11

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住民健診での血清クレアチニン(Cr)とシスタチンC(Cys-C)の5年の変化

櫻井祐成, 山本祐子, 野間さつき, 松田淳也, 雪吹周生

日本腎臓学会誌 55 ( 3 ) 394 - 394 2013.4

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Electrocardiographic Alterations after Percutaneous Transluminal Septal Myocardial Ablation (PTSMA) Demonstrated 1-year Lasting the Chronic Effect

MATSUDA Junya, KITAMURA Mitsunobu, KUBOTA Yoshiaki, NAKAMURA Shunichi, INAMI Shigenobu, TAKANO Hitoshi, ASAI Kuniya, YASUTAKE Masahiro, TAKAYAMA Morimasa, MIZUNO Kyoichi

Circulation Journal 77 ( Supplement 1(CD-ROM) ) 2013

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Clinical Characteristics and Cardiac Magnetic Resonance for the Patients Received Repeating Alcohol Septal Ablation in Refractory Hypertrophic Obstructive Cardiomyopathy

KITAMURA Mitsunobu, TAKAYAMA Morimasa, MATSUDA Junya, KUBOTA Yoshiaki, YOSHIDA Asuka, NAKAMURA Shunichi, TAKANO Hitoshi, ASAI Kuniya, MIZUNO Kyoichi

Circulation Journal 77 ( Supplement 1(CD-ROM) ) 2013

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PTSMA reduce LVOT obstruction and Sokolow-Lyon index in patients with HOCM

MATSUDA Junya, KITAMURA Mitsunobu, KUBOTA Yoshiaki, NAKAMURA Shunichi, YOSHIDA Asuka, TARA Syuhei, MURAI Koji, TOKITA Yuukichi, TAKANO Hitoshi, ASAI Kuniya, YASUTAKE Masahiro, TAKAYAMA Morimasa, MIZUNO Kyouichi

日本心血管インターベンション治療学会誌 4 ( Supplement 2 ) 2012

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急性心筋梗塞による心停止後の胸骨圧迫により肝損傷を来し腹部コンパートメント症候群に陥った一例

松田淳也, 細川雄亮, 林耕次, 宮地秀樹, 山本剛, 佐藤直樹, 白石振一郎, 金史英, 横田裕行, 田中啓治

日本救急医学会雑誌 22 ( 8 ) 680 - 680 2011.8

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胸腔ドレナージにより食物残渣が吸引され,早期診断治療が可能であった特発性食道破裂の1例

松田淳也, 鈴木学, 村井綱児, 中里桂子, 三井誠司, 山本剛, 佐藤直樹, 竹田晋浩, 重原健吾, 野村務, 田中啓治

日本救急医学会雑誌 20 ( 8 ) 471 2009.8

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胸腔ドレナージにより食物残渣が吸引され、早期診断治療が可能であった特発性食道破裂の1例

松田淳也, 鈴木学, 村井綱児, 中里桂子, 三井誠司, 山本剛, 佐藤直樹, 竹田晋浩, 重原健吾, 野村務, 田中啓治

日本救急医学会雑誌 20 ( 8 ) 471 - 471 2009.8

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Awards

優秀賞

2016.10 第49回日本心血管インターベンション治療学会関東甲信越地方会優秀演題セッション

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Research Projects

Development of Partially Regenerated Heart Valves Based on Silk Fibroin for Clinical Application

Grant number：23KK0202 2023.9 - 2027.3

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Fund for the Promotion of Joint International Research (International Collaborative Research)

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Grant amount：\20930000 （ Direct Cost: \16100000 、 Indirect Cost：\4830000 ）

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