Updated on 2025/05/03

写真a

 
Yui Shunsuke
 
Affiliation
Nippon Medical School Hospital, Department of Hematology, Senior Assistant Professor
Title
Senior Assistant Professor
External link

Research Interests

  • AML

Research Areas

  • Life Science / Hematology and medical oncology  / AML

Research History

Papers

  • Disseminated fusariosis successfully treated with empirical liposomal amphotericin B and voriconazole combination followed by ocular therapy in an allogenic hematopoietic stem cell transplant recipient.

    Yuya Kishida, Masahiro Sakaguchi, Tomoyuki Kunishige, Atsushi Takeyoshi, Taichiro Tokura, Kazuki Inai, Ryosuke Kinoshita, Toshio Ibaraki, Satoshi Yamanaka, Toshio Asayama, Shunsuke Yui, Satoshi Wakita, Hiroki Yamaguchi

    Internal medicine (Tokyo, Japan)   2025.4

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    We report the case of a 61-year-old man with chronic myelomonocytic leukemia, who underwent unrelated peripheral blood stem cell transplantation. Fusariosis was suspected prior to identification of the fungal species, and voriconazole and liposomal amphotericin B combination therapy were administered. The patient developed fusarium-related endophthalmitis, accompanied by eye pain. Despite vitrectomy, the endophthalmitis was poorly controlled, and the left eye was enucleated. No recurrence of fusariosis was observed until death following multiple-organ failure due to steroid-resistant graft-versus-host disease.

    DOI： 10.2169/internalmedicine.4657-24

    PubMed

    researchmap

  • 非寛解期CBF関連急性骨髄性白血病に対する同種移植の検討

    由井 俊輔, 柳田 正光, 水野 昌平, 増子 正義, 内田 直之, 吉原 哲, 土岐 典子, 福田 隆浩, 西田 徹也, 衛藤 徹也, 河北 敏郎, 太田 秀一, 鬼塚 真仁, 熱田 由子, 山口 博樹, 小沼 貴晶

    日本血液学会学術集会   86回   O1 - 2   2024.10

    　More details

    Language：English   Publisher：(一社)日本血液学会  

    researchmap

  • Peripheral blood stem cell transplantation using HLA-haploidentical donor with post-transplant cyclophosphamide versus HLA-matched sibling donor for lymphoma International journal

    Yosuke Nakaya, Hirohisa Nakamae, Masashi Nishikubo, Eisei Kondo, Takahiro Fukuda, Nobuhiro Hiramoto, Yasuo Mori, Koji Nagafuji, Tetsuya Eto, Yasushi Onishi, Naoyuki Uchida, Jun Ishikawa, Ken-ichi Matsuoka, Shunsuke Yui, Ken Takase, Toshiro Kawakita, Junya Kanda, Tatsuo Ichinohe, Yoshiko Atsuta, Shinichi Kako

    Bone Marrow Transplantation   59 ( 5 )   630 - 636   2024.5

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    Data comparing HLA-haploidentical donors and HLA-matched sibling donors (MSDs) in peripheral blood stem cell transplantation (PBSCT) for lymphoma are scarce. We retrospectively analyzed 465 patients with lymphoma aged 16 years or older who underwent PBSCT using haploidentical donors with post-transplant cyclophosphamide (PTCy-haplo) (n = 166) or MSDs with calcineurin inhibitor-based graft-versus-host disease (GVHD) prophylaxis (n = 299). Two-year overall survival (OS), progression-free survival (PFS), and GVHD-free, relapse-free survival (GRFS) in the PTCy-haplo and MSD groups were 49.2% versus 51.9% (P = 0.64), 38.0% versus 39.9% (P = 0.97), and 27.7% versus 18.5% (P = 0.006), respectively. In multivariable analyses, PTCy-haplo recipients had slower neutrophil recovery (hazard ratio [HR], 0.62; P < 0.001) and platelet recovery (HR, 0.54; P < 0.001), lower risk of chronic GVHD (HR, 0.64; P = 0.038) and extensive chronic GVHD (HR, 0.45; P = 0.008), and better GRFS (HR, 0.66; P = 0.003) than MSD transplant recipients. OS, PFS, relapse or progression, and non-relapse mortality were similar between the groups. The difference might be mainly due to PTCy use rather than donor type; however, the results suggested that PTCy-haplo could be a possible option as an alternative to conventional MSD transplantation for lymphoma in PBSCT.

    DOI： 10.1038/s41409-024-02229-y

    PubMed

    researchmap

  • Dasatinibによる可逆性後白質脳症症候群(PRES)を呈した急性転化期慢性骨髄性白血病

    田中 康平, 由井 俊輔, 竹吉 敦志, 福永 景子, 山口 博樹

    臨床血液   65 ( 4 )   304 - 304   2024.4

    　More details

    Language：Japanese   Publisher：(一社)日本血液学会-東京事務局  

    researchmap

  • Dasatinibによる可逆性後白質脳症症候群(PRES)を呈した急性転化期慢性骨髄性白血病

    田中 康平, 由井 俊輔, 竹吉 敦志, 福永 景子, 山口 博樹

    臨床血液   65 ( 4 )   304 - 304   2024.4

    　More details

    Language：Japanese   Publisher：(一社)日本血液学会-東京事務局  

    researchmap

  • 造血器疾患患者においてClostridioides infection発症時は抗菌薬を中止すべきか

    稲井 一貴, 丸毛 淳史, 阪口 正洋, 朝山 敏夫, 由井 俊輔, 脇田 知志, 山口 博樹

    日本内科学会雑誌   113 ( 臨増 )   158 - 158   2024.2

    　More details

    Language：Japanese   Publisher：(一社)日本内科学会  

    researchmap

  • 造血器疾患患者におけるClostridioides infectionと広域抗菌薬治療の関係

    稲井 一貴, 丸毛 淳史, 阪口 正洋, 由井 俊輔, 脇田 知志, 山口 博樹, 篠山 明宏

    日本医科大学医学会雑誌   19 ( 4 )   396 - 396   2023.12

    　More details

    Language：Japanese   Publisher：日本医科大学医学会  

    researchmap

  • Picture in Clinical Hematology(No.159) 再発難治急性骨髄性白血病に対するHLA半合致同種造血幹細胞移植後に発症した皮膚フサリウム症

    竹吉 敦志, 丸毛 淳史, 山田 麻以, 田中 康平, 福永 景子, 由井 俊輔, 脇田 知志, 坂谷 貴司, 大橋 隆治, 山口 博樹

    臨床血液   64 ( 11 )   1395 - 1395   2023.11

    　More details

  • Picture in Clinical Hematology(No.159) 再発難治急性骨髄性白血病に対するHLA半合致同種造血幹細胞移植後に発症した皮膚フサリウム症

    竹吉 敦志, 丸毛 淳史, 山田 麻以, 田中 康平, 福永 景子, 由井 俊輔, 脇田 知志, 坂谷 貴司, 大橋 隆治, 山口 博樹

    臨床血液   64 ( 11 )   1395 - 1395   2023.11

    　More details

  • 免疫抑制療法にエミシズマブを併用して前立腺生検を行った後天性血友病Aの症例

    稲井 一貴, 由井 俊輔, 尾内 大志, 朝山 敏夫, 脇田 知志, 森下 英理子, 山口 博樹

    臨床血液   64 ( 10 )   1345 - 1345   2023.10

    　More details

    Language：Japanese   Publisher：(一社)日本血液学会-東京事務局  

    researchmap

  • 造血器疾患患者におけるClostridioides infectionと広域抗菌薬治療の関係

    稲井 一貴, 丸毛 淳史, 鷲尾 洋平, 篠山 明宏, 阪口 正洋, 由井 俊輔, 脇田 知志, 山口 博樹

    日本血液学会学術集会   85回   735 - 735   2023.10

    　More details

    Language：English   Publisher：(一社)日本血液学会  

    researchmap

  • 診断に難渋した後天性血友病Aの症例

    稲井 一貴, 脇田 知志, 由井 俊輔, 木戸 俊輔, 深澤 美樹, 山口 博樹, 森下 英理子

    日本血栓止血学会誌   34 ( 2 )   262 - 262   2023.5

    　More details

    Language：Japanese   Publisher：(一社)日本血栓止血学会  

    researchmap

  • 診断に難渋した後天性血友病Aの症例

    稲井 一貴, 脇田 知志, 由井 俊輔, 木戸 俊輔, 深澤 美樹, 山口 博樹, 森下 英理子

    日本血栓止血学会誌   34 ( 2 )   262 - 262   2023.5

    　More details

    Language：Japanese   Publisher：(一社)日本血栓止血学会  

    researchmap

  • 同種造血幹細胞移植にてようやく寛解に至った難治性毛包向性菌状息肉症の1例

    井渕 善聖, 尾崎 紗恵子, 魚住 知美, 三神 絵里奈, 由井 俊輔, 山口 博樹, 佐伯 秀久, 船坂 陽子

    日本皮膚科学会雑誌   133 ( 5 )   1412 - 1412   2023.5

    　More details

    Language：Japanese   Publisher：(公社)日本皮膚科学会  

    researchmap

  • Epstein-Barr virus-related hemophagocytic lymphohistiocytosis with central nervous system symptoms.

    Masahiro Sakaguchi, Yasunobu Nagata, Yasuhiro Terasaki, Atsushi Takeyoshi, Syunichi Yasuda, Shunsuke Honma, Ryosuke Kinoshita, Atsushi Marumo, Toshio Asayama, Shunsuke Yui, Satoshi Wakita, Muneo Okamoto, Yusuke Kajimoto, Koiti Inokuchi, Hiroki Yamaguchi

    Journal of Nippon Medical School = Nippon Ika Daigaku zasshi   2022.11

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    Hemophagocytic lymphohistiocytosis (HLH) involves pathological histiocytes and phagocytosis of normal blood cells through activation of inflammatory cytokines. We report a case of Epstein-Barr virus-HLH in a 75-year-old woman who presented with fever, thrombocytopenia, and loss of consciousness. Epstein-Barr virus-HLH was diagnosed after we identified massive hemophagocytosis in bone marrow and Epstein-Barr virus DNA in cerebrospinal fluid. The HLH-2004 protocol was applied, and lactate dehydrogenase levels-which reflect HLH disease status-decreased. However, persistent loss of consciousness and multiple organ failure led to the patient' s death on day 18. Most cases of primary and secondary HLH involve pediatric patients; adult cases are rare. Few cases of central nervous system involvement in older adults have been reported. Therefore, accumulation of more data will help in developing better treatment strategies.

    DOI： 10.1272/jnms.JNMS.2023_90-105

    PubMed

    researchmap

  • 筋移植片対宿主病発症後に致死的な肺移植片対宿主病を発症したPh陽性急性リンパ性白血病

    浅葉 惇, 朝山 敏夫, 由井 俊輔, 丸毛 淳史, 尾内 大志, 永田 安伸, 脇田 知志, 山口 博樹

    臨床血液   63 ( 10 )   1464 - 1464   2022.10

    　More details

    Language：Japanese   Publisher：(一社)日本血液学会-東京事務局  

    researchmap

  • Simultaneous detection of <scp> JAK2 </scp> , <scp> CALR </scp> , and <scp> MPL </scp> mutations and quantitation of <scp> JAK2 V617F </scp> allele burden in myeloproliferative neoplasms using the quenching <scp>probe‐Tm</scp> method in i‐densy <scp>IS</scp> ‐5320

    Kunihito Arai, Masahiro Sakaguchi, Shunsuke Yui, Tomoaki Kitano, Miho Miyata, Mayumi Yogosawa, Kazutaka Nakayama, Kenji Tajika, Kensuke Usuki, Junya Kuroda, Nobuhiko Uoshima, Yutaka Kobayashi, Hitoji Uchiyama, Yasushi Kubota, Shinya Kimura, Shinichiro Mori, Mitsuharu Hirai, Satoshi Wakita, Hiroki Yamaguchi

    International Journal of Laboratory Hematology   2022.8

    　More details

    Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    DOI： 10.1111/ijlh.13938

    researchmap

    Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1111/ijlh.13938

  • Safety and efficacy of high-dose cytarabine MEAM therapy and other treatments for auto-peripheral blood stem cell transplantation: A retrospective comparative study. International journal

    Shunsuke Yui, Satoshi Wakita, Yasunobu Nagata, Yasuko Kuribayashi, Toshio Asayama, Yusuke Fujiwara, Masahiro Sakaguchi, Satoshi Yamanaka, Atsushi Marumo, Ikuko Omori, Ryosuke Kinoshita, Daishi Onai, Mika Sunakawa, Yuta Kaito, Kazuki Inai, Taichiro Tokura, Atsushi Takeyoshi, Shunichi Yasuda, Shunsuke Honma, Kazutaka Nakayama, Tsuneaki Hirakawa, Kunihito Arai, Tomoaki Kitano, Muneo Okamoto, Koiti Inokuchi, Hiroki Yamaguchi

    Asia-Pacific journal of clinical oncology   19 ( 1 )   136 - 148   2022.5

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    AIM: The MEAM regimen consisting of ranimustine (MCNU), etoposide (ETP), cytarabine (Ara-C), and melphalan (MEL) is widely used before auto-peripheral blood stem cell transplantation (auto-PBSCT) for malignant lymphoma in Japan. The MEAM regimen generally consists of 200-400 mg/m2 for 4 days, but we decided to increase the dosage of Ara-C from the standard to 2 g/m2 for 2 days with the aim of increasing drug transferability to the central nervous system. We evaluate the safety and therapeutic efficacy of high-dose Ara-C MEAM therapy. METHODS: The high-dose Ara-C MEAM protocol consisted of MCNU 300 mg/m2 on day -7, ETP 200 mg/m2 on days -6, -5, -4, -3 and Ara-C 2 g/m2 on day -4 -3, and MEL 140 mg/m2 on day -2. We retrospectively analyzed 37 cases of malignant lymphoma at our institution between May 2014 and July 2020. RESULTS: All patients got engraftment and there were no cases of treatment-related mortality. In all cases, the 3-year overall survival (OS) and progression-free survival (PFS) after transplantation were 80.6% and 65.7%, respectively. Twenty-one cases of diffuse large B-cell lymphoma recurrence, for which there is proven usefulness of auto-PBSCT, showed good results after transplantation, with the 3-year OS and PFS after transplantation being 100% and 74.3%, respectively. CONCLUSION: The safety and efficacy of high-dose Ara-C MEAM therapy were demonstrated, but the expected therapeutic effect on central nervous system lesions could not be fully evaluated owing to the small number of cases.

    DOI： 10.1111/ajco.13780

    PubMed

    researchmap

  • 好酸球増多を伴う骨髄異形成症候群に劇症型好酸球性心筋症を合併した1剖検例

    竹吉 敦志, 脇田 知志, 本間 俊佑, 保田 駿一, 土蔵 太一郎, 稲井 一貴, 丸毛 淳史, 山中 聡, 阪口 正洋, 永田 安伸, 由井 俊輔, 岡本 宗雄, 山口 博樹

    臨床血液   63 ( 5 )   494 - 494   2022.5

    　More details

    Language：Japanese   Publisher：(一社)日本血液学会-東京事務局  

    researchmap

  • NPM1-mutation-based measurable residual disease assessment after completion of two courses of post-remission therapy is a valuable clinical predictor of the prognosis of acute myeloid leukemia.

    Atsushi Marumo, Satoshi Wakita, Kaoru Morita, Iekuni Oh, Shinichi Kako, Takashi Toya, Yuho Najima, Noriko Doki, Junya Kanda, Junya Kuroda, Shinichiro Mori, Atsushi Satake, Kensuke Usuki, Nobuhiko Uoshima, Yutaka Kobayashi, Eri Kawata, Yuhei Nagao, Katsuhiro Shono, Motoharu Shibusawa, Jiro Tadokoro, Masao Hagihara, Hitoji Uchiyama, Yasushi Kubota, Shinya Kimura, Sayuri Motomura, Akiko Hashimoto, Hideharu Muto, Eriko Sato, Masao Ogata, Kenjiro Mitsuhashi, Jun Ando, Kenta Date, Yusuke Fujiwara, Kazuki Terada, Shunsuke Yui, Kunihito Arai, Tomoaki Kitano, Miho Miyata, Kazuteru Ohashi, Yoshinobu Kanda, Hiroki Yamaguchi

    International journal of hematology   116 ( 2 )   199 - 214   2022.4

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    Recent studies have reported that measurable residual disease (MRD) analysis using NPM1 mutations helps determine whether allogeneic hematopoietic stem cell transplantation (allo-HSCT) is indicated in acute myeloid leukemia (AML) patients. However, the optimal timing and cutoff value for measuring MRD using genomic DNA remain undetermined. This study aimed to investigate the optimal timing and cutoff value to ascertain the value of NPM1 mutation in MRD assessment. NPM1-mutated MRD was quantified by real-time polymerase chain reaction of bone marrow samples from 56 patients with NPM1-positive AML who achieved hematological remission. The area under the receiver-operating characteristic curve was greatest when MRD was assessed after two courses of post-remission therapy with a cutoff value of 0.010% (specificity, 68.4%; sensitivity, 87.0%). Patients whose MRD was below the cutoff value throughout the course of treatment had significantly better overall survival and relapse-free survival rates. Of the 33 patients who did not undergo transplantation during the first remission, all of the 11 who were never MRD-negative at any point experienced a relapse. Evaluating MRD with a cutoff value of 0.010% after two courses of post-remission therapy helps predict prognosis and determine the indication for allo-HSCT.

    DOI： 10.1007/s12185-022-03328-6

    PubMed

    researchmap

  • 予後不良因子を複数伴った化学療法抵抗性のCD19陽性AMLに対して臍帯血移植が奏効した1例

    山口 玲, 阪口 正洋, 稲井 一貴, 土蔵 太一朗, 竹吉 敦志, 保田 駿一, 本間 俊佑, 尾内 大志, 砂川 実香, 丸毛 淳史, 山中 聡, 朝山 敏夫, 永田 安伸, 由井 俊輔, 脇田 知志, 岡本 宗雄, 山口 博樹, 猪口 孝一

    臨床血液   62 ( 10 )   1522 - 1522   2021.10

    　More details

    Language：Japanese   Publisher：(一社)日本血液学会-東京事務局  

    researchmap

  • 全自動遺伝子解析装置i-densy IS-5320を用いた造血器腫瘍における転座型遺伝子異常検出の有用性の検討(Examination of the usefulness of translocation-type gene abnormality detection using i-densy IS-5320)

    由井 俊輔, 岡本 宗雄, 脇田 知志, 永田 安伸, 栗林 泰子, 朝山 敏夫, 藤原 裕介, 阪口 正洋, 山中 聡, 丸毛 淳史, 大森 郁子, 木下 量介, 尾内 大志, 砂川 実香, 海渡 裕太, 稲井 一貴, 土蔵 太一朗, 竹吉 敦志, 保田 駿一, 本間 俊佑, 荒井 邦仁, 北野 智章, 宮田 美保, 土岐 典子, 諫田 淳也, 平井 光春, 木寺 一喜, 猪口 孝一, 山口 博樹

    日本血液学会学術集会   83回   PS - 2   2021.9

    　More details

    Language：English   Publisher：(一社)日本血液学会  

    researchmap

  • An advanced case of gastric histiocytic sarcoma treated with chemotherapy and gastrectomy: a case report and review of literature

    Ryu Matsunaga, Yoshikazu Kanazawa, Kunihiko Matsuno, Daisuke Kakinuma, Taichiro Tokura, Atsushi Marumo, Shunsuke Yui, Fumihiko Ando, Yuka Masuda, Nobutoshi Hagiwara, Tsutomu Nomura, Shunji Kato, Toshiro Yoshiyuki, Yukako Domoto, Takashi Sakatani, Ryuji Ohashi, Koiti Inokuchi, Hiroshi Yoshida

    Clinical Journal of Gastroenterology   14 ( 4 )   1053 - 1059   2021.8

    　More details

    Publishing type：Research paper (scientific journal)  

    Histiocytic sarcoma is a relatively new disease category and the gastrointestinal origin is sporadic. We report a case of a 74-year-old woman who underwent chemotherapy and proximal gastrectomy for extremely rare, advanced gastric histiocytic sarcoma. The resected specimen was subjected to numerous immunostainings to meet the diagnostic criteria of histiocytic sarcoma and was positive for the histiocyte markers’ cluster of differentiation 68 and lysozyme. The markers of Langerhans cells, follicular dendritic cells, and myelocyte were all negative. Six reports of surgical resection of histiocytic sarcoma originating in the stomach exist, including our case. We reviewed the clinical course and the histological and immunohistochemical diagnostic features of surgically resected gastric histiocytic sarcoma.

    DOI： 10.1007/s12328-021-01438-y

    Scopus

    PubMed

    researchmap

  • An advanced case of gastric histiocytic sarcoma treated with chemotherapy and gastrectomy: a case report and review of literature.

    Ryu Matsunaga, Yoshikazu Kanazawa, Kunihiko Matsuno, Daisuke Kakinuma, Taichiro Tokura, Atsushi Marumo, Shunsuke Yui, Fumihiko Ando, Yuka Masuda, Nobutoshi Hagiwara, Tsutomu Nomura, Shunji Kato, Toshiro Yoshiyuki, Yukako Domoto, Takashi Sakatani, Ryuji Ohashi, Koiti Inokuchi, Hiroshi Yoshida

    Clinical journal of gastroenterology   14 ( 4 )   1053 - 1059   2021.8

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    Histiocytic sarcoma is a relatively new disease category and the gastrointestinal origin is sporadic. We report a case of a 74-year-old woman who underwent chemotherapy and proximal gastrectomy for extremely rare, advanced gastric histiocytic sarcoma. The resected specimen was subjected to numerous immunostainings to meet the diagnostic criteria of histiocytic sarcoma and was positive for the histiocyte markers' cluster of differentiation 68 and lysozyme. The markers of Langerhans cells, follicular dendritic cells, and myelocyte were all negative. Six reports of surgical resection of histiocytic sarcoma originating in the stomach exist, including our case. We reviewed the clinical course and the histological and immunohistochemical diagnostic features of surgically resected gastric histiocytic sarcoma.

    DOI： 10.1007/s12328-021-01438-y

    PubMed

    researchmap

  • Central Nervous System-related Graft-versus-host Disease after Allogeneic Hematopoietic Stem Cell Transplantation.

    Yuta Kaito, Shunsuke Yui, Kazuki Inai, Daishi Onai, Ryosuke Kinoshita, Satoshi Yamanaka, Muneo Okamoto, Ryuichi Wada, Ryuji Ohashi, Koiti Inokuchi, Hiroki Yamaguchi

    Internal medicine (Tokyo, Japan)   60 ( 20 )   3299 - 3304   2021

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    Allogeneic hemopoietic stem cell transplantation (allo-HSCT) is the only curative therapy for refractory hematological malignancies. However, there are many treatment-related complications, including organ disorders, graft-versus-host disease (GVHD), and infectious diseases. Furthermore, there are many unclear points regarding central nervous system (CNS) complications, and the prognosis in patients with CNS complications is extremely poor. We herein report a 49-year-old woman who developed CNS-GVHD after a second transplantation for therapy-related myelodysplastic syndrome. CNS-GVHD in this case was refractory to all treatments, including steroids, and progressed. We also present a review of the literature about the symptoms, diagnosis, and treatment of CNS-GVHD.

    DOI： 10.2169/internalmedicine.6351-20

    PubMed

    researchmap

  • The prognostic impact of FLT3-ITD, NPM1 and CEBPa in cytogenetically intermediate-risk AML after first relapse. Reviewed

    Saiko Kurosawa, Hiroki Yamaguchi, Takuhiro Yamaguchi, Keiko Fukunaga, Shunsuke Yui, Heiwa Kanamori, Kensuke Usuki, Nobuhiko Uoshima, Masamitsu Yanada, Jin Takeuchi, Ishikazu Mizuno, Junya Kanda, Hiroshi Okamura, Shingo Yano, Haruko Tashiro, Takero Shindo, Shigeru Chiba, Junji Tomiyama, Koiti Inokuchi, Takahiro Fukuda

    International journal of hematology   112 ( 2 )   200 - 209   2020.8

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    We evaluated the impact of FLT3-ITD, NPM1 mutations, and double mutant CEBPa (dmCEBPa) on overall survival (OS) after relapse in patients with cytogenetically intermediate-risk acute myeloid leukemia (AML) who were treated with chemotherapy alone in the first remission (CR1). Patients aged 16-65 years diagnosed with cytogenetically intermediate-risk AML, and who achieved CR1 were included. We retrospectively analyzed FLT3-ITD, NPM1 mutations and CEBPa using samples obtained at diagnosis, which therefore did not affect the therapeutic decisions. Among 235 patients who had achieved CR1, 152 relapsed, and 52% of them achieved second CR. The rate of achieving second CR was significantly higher (85%) in those with dmCEBPa. Patients with FLT3-ITD had significantly worse OS after relapse than those without (19% vs 41%, p = 0.002), while OS was comparable between patients with and without NPM1 mutations (37% vs 34%, p = 0.309). Patients with dmCEBPa had improved OS than those without (61% vs 32%, p = 0.006). By multivariate analysis, FLT3-ITD was independently associated with worse OS after relapse [hazard ratio (HR) 1.99, 95% CI 1.27-3.12, p = 0.003], and dmCEBPa with improved OS (HR 0.40, 95% CI 0.17-0.93, p = 0.033). Our data show that screening for these mutations at diagnosis is useful for facilitating effective therapeutic decision-making even after relapse.

    DOI： 10.1007/s12185-020-02894-x

    PubMed

    researchmap

  • 高カルシウム血症から洞停止を起こした骨融解型の濾胞性リンパ腫の1例

    土蔵 太一朗, 由井 俊輔, 砂川 実香, 岡本 宗雄, 山口 博樹, 猪口 孝一

    臨床血液   61 ( 8 )   991 - 991   2020.8

    　More details

    Language：Japanese   Publisher：(一社)日本血液学会-東京事務局  

    researchmap

  • Cohesin遺伝子変異を伴う急性骨髄性白血病の臨床的特徴と予後

    久保山 まりか, 伊達 健太, 阪口 正洋, 植木 俊充, 臼杵 憲祐, 小林 裕, 田近 賢二, 黒澤 彩子, 稲井 一貴, 尾内 大志, 丸毛 淳史, 大森 郁子, 山中 聡, 藤原 裕介, 由井 俊輔, 脇田 知志, 岡本 宗雄, 寺田 和樹, 福田 隆浩, 山口 博樹, 猪口 孝一

    臨床血液   61 ( 8 )   988 - 988   2020.8

    　More details

    Language：Japanese   Publisher：(一社)日本血液学会-東京事務局  

    researchmap

  • Outcomes of Patients with Early Hyperbilirubinemia after Allogeneic Hematopoietic Stem Cell Transplantation.

    Ikuko Omori, Hiroki Yamaguchi, Tsuneaki Hirakawa, Kazuki Inai, Daishi Onai, Atsushi Marumo, Satoshi Yamanaka, Masahiro Sakaguchi, Yusuke Fujiwara, Satoshi Wakita, Muneo Okamoto, Hayato Tamai, Kazutaka Nakayama, Shunsuke Yui, Koiti Inokuchi

    Journal of Nippon Medical School = Nippon Ika Daigaku zasshi   87 ( 3 )   142 - 152   2020.7

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: Because the cause of liver dysfunction after allogeneic hematopoietic stem cell transplantation (HSCT) is difficult to identify in the early stages, treatment may be delayed. Therefore, early factors associated with unfavorable outcomes of liver dysfunction must be identified. The objective of this study was to identify unfavorable prognostic factors for liver dysfunction during the early period after transplantation. METHODS: We defined liver dysfunction as elevated liver or biliary enzyme levels (corresponding to Grade 2 in the Common Terminology Criteria for Adverse Events version 4.0) within 30 days of transplantation and retrospectively investigated data from 82 patients who had undergone allogeneic HSCT at our center. RESULTS: Elevated liver or biliary enzyme levels were observed in almost half of the patients studied (n=40, 48.7%). Elevated total bilirubin (T-Bil) level was the most frequently observed unfavorable prognostic factor and had the greatest effect on overall survival (OS), progression-free survival (PFS), and non-relapse mortality (NRM) (probability of unfavorable outcome in patients without and with elevated T-Bil level: OS, 58.9% vs. 15.4%, p < 0.001; PFS, 46.4% vs. 15.4%, p < 0.001; NRM, 10.7% vs. 53.8%, p < 0.001). Moreover, the probability of an unfavorable outcome increased in relation to the degree of T-Bil elevation and absence of improvement over time in T-Bil level. CONCLUSION: Elevated T-Bil level was an important marker of outcomes for liver dysfunction after allogeneic HSCT.

    DOI： 10.1272/jnms.JNMS.2020_87-404

    PubMed

    researchmap

  • The sensitivity of the FLT3-ITD detection method is an important consideration when diagnosing acute myeloid leukemia. International journal

    Masahiro Sakaguchi, Nana Nakajima, Hiroki Yamaguchi, Yuho Najima, Katsuhiro Shono, Atsushi Marumo, Ikuko Omori, Yusuke Fujiwara, Kazuki Terada, Shunsuke Yui, Satoshi Wakita, Miho Mitaya, Kunihito Arai, Tomoaki Kitano, Noriko Doki, Kazuteru Ohashi, Koiti Inokuchi

    Leukemia research reports   13   100198 - 100198   2020

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    Fms-like tyrosine kinase 3-internal tandem duplication (FLT3-ITD) is a key predictive factor for the prognosis of acute myeloid leukemia (AML). We compared the detection sensitivity of fragment analysis with that of PCR-electrophoresis using MV4-11 (FLT3-ITD) and NKM-1 (FLT3-wild type) cell lines. DNA of these cells was mixed at different ratios and subjected to PCR-electrophoresis or fragment analysis. PCR-electrophoresis was found to have an FLT3-ITD allelic ratio (AR) detection limit of 0.034-0.072. Visual inspection of the PCR-electrophoresis revealed a lower detection sensitivity than that of fragment analysis. Therefore, it is essential to conduct fragment analysis when screening for FLT3-ITD.

    DOI： 10.1016/j.lrr.2020.100198

    PubMed

    researchmap

  • Presence of promyelocytes in peripheral blood as a novel predictor of the optimal timing for single-step peripheral blood stem cell collection

    Atsushi Marumo, Hiroki Yamaguchi, Tsuneaki Hirakawa, Kazuki Inai, Daishi Onai, Ikuko Omori, Satoshi Yamanaka, Yusuke Fujiwara, Masahiro Sakaguchi, Satoshi Wakita, Muneo Okamoto, Shunsuke Yui, Koiti Inokuchi

    Journal of Nippon Medical School   88 ( 1 )   45 - 53   2020

    　More details

    Publishing type：Research paper (scientific journal)   Publisher：Medical Association of Nippon Medical School  

    DOI： 10.1272/jnms.jnms.2021_88-104

    researchmap

  • Risk Factors for Acute Kidney Injury and Chronic Kidney Disease following Allogeneic Hematopoietic Stem Cell Transplantation for Hematopoietic Malignancies. Reviewed

    Sakaguchi M, Nakayama K, Yamaguchi H, Mii A, Shimizu A, Inai K, Onai D, Marumo A, Omori I, Yamanaka S, Fujiwara Y, Fukunaga K, Ryotokuji T, Hirakawa T, Okabe M, Tamai H, Okamoto M, Wakita S, Yui S, Tsuruoka S, Inokuchi K

    Acta haematologica   143 ( 5 )   1 - 13   2019.12

    　More details

    Publishing type：Research paper (scientific journal)   Publisher：S. Karger AG  

    Background: Acute kidney injury (AKI) and chronic kidney disease (CKD) are considered common complications after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Objectives and Method: In this study, 114 patients who had undergone allo-HSCT were retrospectively analyzed to investigate the risk factors for onset of posttransplant AKI and CKD as defined by the new Kidney Disease Improving Global Outcomes criteria. Results: Seventy-four patients (64.9%) developed AKI and 25 (21.9%) developed CKD. The multivariate analysis showed that the risk factors for developing stage 1 or higher AKI were age ≥46 years at the time of transplant (p = 0.001) and use of ≥3 nephrotoxic drugs (p = 0.036). For CKD, the associated risk factors were disease status other than complete remission at the time of transplantation (p = 0.018) and onset of AKI after transplant (p = 0.035). The 5-year overall survival (OS) was significantly reduced by development of AKI (p &lt; 0.001), but not CKD. Posttransplant AKI significantly increased the 5-year nonrelapse mortality (p &lt; 0.001), whereas posttransplant CKD showed an increasing tendency, but the difference was not significant. Conclusions: Posttransplant AKI impacts OS, significantly increases the risk of CKD, and is significantly associated with disseminated intravascular coagulation and use of ˃3 nephrotoxic drugs.

    DOI： 10.1159/000504354

    PubMed

    researchmap

  • Significance of FLT3-tyrosine kinase domain mutation as a prognostic factor for acute myeloid leukemia. Reviewed

    Masahiro Sakaguchi, Hiroki Yamaguchi, Marika Kuboyama, Yuho Najima, Kensuke Usuki, Toshimitsu Ueki, Iekuni Oh, Shinichiro Mori, Eri Kawata, Nobuhiko Uoshima, Yutaka Kobayashi, Shinichi Kako, Kenji Tajika, Katsuhiro Shono, Kensuke Kayamori, Masao Hagihara, Junya Kanda, Hitoji Uchiyama, Junya Kuroda, Naoyuki Uchida, Yasushi Kubota, Shinya Kimura, Saiko Kurosawa, Kenta Date, Nana Nakajima, Atsushi Marumo, Ikuko Omori, Yusuke Fujiwara, Kazuki Terada, Shunsuke Yui, Satoshi Wakita, Kunihito Arai, Tomoaki Kitano, Kazuhiko Kakihana, Yoshinobu Kanda, Kazuteru Ohashi, Takahiro Fukuda, Koiti Inokuchi

    International journal of hematology   110 ( 5 )   566 - 574   2019.11

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    The prognostic significance of FLT3-tyrosine kinase domain (TKD) mutations remains unknown. To investigate the prognostic impact of FLT3-TKD, 676 de novo acute myeloid leukemia (AML), we retrospectively analyzed cases and conducted a review of the literature. Of the 676 de novo AML cases, 34 (5.0%) were FLT3-TKD-positive; both FLT3-TKD and FLT3-ITD were noted in only two cases (0.3%). Although no significant differences in relapse-free survival (RFS) were noted, FLT3-TKD-positive cases showed better prognoses than FLT3-ITD-positive cases (FLT3-TKD versus FLT3-ITD, p = 0.152). For overall survival (OS), although FLT3-TKD-positive cases showed prognoses similar to those for FLT3-WT cases, their prognoses were significantly better than those of FLT3-ITD-positive cases (FLT3-TKD versus FLT3-ITD, p = 0.032). Moreover, the 5-year OS for FLT3-TKD-positive cases was 46.1%, indicating that this as an intermediate prognosis group. Although no reports from Asia have indicated a frequency of FLT3-TKD-positive cases > 10%, several reports from Europe and the United States have indicated frequencies > 10%. This suggests the possibility that FLT3-TKD-positive cases are less common in Asia than in Europe and the United States. We anticipate that in the future, the appearance of targeting agents, such as FLT3 inhibitors, will improve the prognosis of FLT3-TKD-positive AML relative to that of FLT3-WT AML.

    DOI： 10.1007/s12185-019-02720-z

    PubMed

    researchmap

  • 末梢血幹細胞採取を単回でおこなう為の最適な時期予測における前骨髄球発現の有用性の検討

    丸毛 淳史, 山口 博樹, 平川 経晃, 稲井 一貴, 尾内 大志, 大森 郁子, 山中 聡, 藤原 裕介, 阪口 正洋, 岡部 雅弘, 脇田 知志, 岡本 宗雄, 由井 俊輔, 猪口 孝一

    日本医科大学医学会雑誌   15 ( 4 )   241 - 241   2019.10

    　More details

    Language：Japanese   Publisher：日本医科大学医学会  

    researchmap

  • 急速に進行する多発動脈狭窄と脳梗塞を伴った本態性血小板血症の1例

    高橋 康大, 片野 雄大, 村賀 香名子, 鈴木 健太郎, 鈴木 文昭, 鈴木 亨尚, 木村 和美, 由井 俊輔, 山口 博樹, 猪口 孝一

    日本医科大学医学会雑誌   15 ( 4 )   265 - 265   2019.10

    　More details

    Language：Japanese   Publisher：日本医科大学医学会  

    researchmap

  • フィラデルフィア染色体陽性急性リンパ性白血病と鑑別が困難であった慢性骨髄性白血病の急性転化

    安田 優輝, 脇田 知志, 由井 俊輔, 山方 俊弘, 丸毛 淳史, 大森 郁子, 岡本 宗雄, 山口 博樹, 猪口 孝一

    臨床血液   60 ( 10 )   1497 - 1497   2019.10

    　More details

    Language：Japanese   Publisher：(一社)日本血液学会-東京事務局  

    researchmap

  • 新鮮凍結血漿補充により診断に苦慮した後天性第V因子欠乏症の1例

    稲井 一貴, 山口 博樹, 海渡 裕太, 尾内 大志, 由井 俊輔, 脇田 知志, 岡本 宗雄, 田村 秀人, 丸毛 淳史, 猪口 孝一

    臨床血液   60 ( 5 )   520 - 521   2019.5

    　More details

    Language：Japanese   Publisher：(一社)日本血液学会-東京事務局  

    researchmap

  • Importance of prognostic stratification via gene mutation analysis in elderly patients with acute myelogenous leukemia. Reviewed

    Fujiwara Y, Yamaguchi H, Yui S, Tokura T, Inai K, Onai D, Omori I, Marumo A, Yamanaka S, Sakaguchi M, Terada K, Nakagome S, Arai K, Kitano T, Okabe M, Okamoto M, Tamai H, Nakayama K, Tajika K, Wakita S, Inokuchi K

    International journal of laboratory hematology   41 ( 4 )   461 - 471   2019.4

    　More details

    Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    DOI： 10.1111/ijlh.13025

    PubMed

    researchmap

    Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1111/ijlh.13025

  • 血液内科病棟におけるバンコマイシン(VCM)とピペラシリン/タゾバクタム(PIPC/TAZ)併用療法の急性腎障害(AKI)発症に関する検討

    尾内 大志, 稲井 一貴, 海渡 裕太, 丸毛 淳史, 阪口 正洋, 由井 俊輔, 脇田 知志, 岡本 宗雄, 山口 博樹, 猪口 孝一

    日本内科学会雑誌   108 ( Suppl. )   202 - 202   2019.2

    　More details

    Language：Japanese   Publisher：(一社)日本内科学会  

    researchmap

  • Prognostic impact of low allelic ratio FLT3-ITD and NPM1 mutation in acute myeloid leukemia. Reviewed International journal

    Masahiro Sakaguchi, Hiroki Yamaguchi, Yuho Najima, Kensuke Usuki, Toshimitsu Ueki, Iekuni Oh, Sinichiro Mori, Eri Kawata, Nobuhiko Uoshima, Yutaka Kobayashi, Shinichi Kako, Kenji Tajika, Seiji Gomi, Katsuhiro Shono, Kensuke Kayamori, Masao Hagihara, Junya Kanda, Hitoji Uchiyama, Junya Kuroda, Naoyuki Uchida, Yasushi Kubota, Shinya Kimura, Saiko Kurosawa, Nana Nakajima, Atsushi Marumo, Ikuko Omori, Yusuke Fujiwara, Shunsuke Yui, Satoshi Wakita, Kunihito Arai, Tomoaki Kitano, Kazuhiko Kakihana, Yoshinobu Kanda, Kazuteru Ohashi, Takahiro Fukuda, Koiti Inokuchi

    Blood advances   2 ( 20 )   2744 - 2754   2018.10

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    In the opinion of the European LeukemiaNet (ELN), nucleophosmin member 1 gene mutation (NPM1 mut)-positive acute myeloid leukemia (AML) with an fms-like kinase 3-internal tandem duplication (FLT3-ITD) allele ratio (AR) <0.5 (low AR) has a favorable prognosis, and allogeneic hematopoietic stem cell transplant (allo-HSCT) in the first complete remission (CR1) period is not actively recommended. We studied 147 patients with FLT3-ITD gene mutation-positive AML, dividing them into those with low AR and those with AR of ≥0.5 (high AR), and examined the prognostic impact according to allo-HSCT in CR1. Although FLT3-ITD AR and NPM1 mut are used in the prognostic stratification, we found that NPM1 mut-positive AML with FLT3-ITD low AR was not associated with favorable outcome (overall survival [OS], 41.3%). Moreover, patients in this group who underwent allo-HSCT in CR1 had a significantly more favorable outcome than those who did not (relapse-free survival [RFS] P = .013; OS P = .003). Multivariate analysis identified allo-HSCT in CR1 as the sole favorable prognostic factor (RFS P < .001; OS P < .001). The present study found that prognosis was unfavorable in NPM1 mut-positive AML with FLT3-ITD low AR when allo-HSCT was not carried out in CR1.

    DOI： 10.1182/bloodadvances.2018020305

    PubMed

    researchmap

  • PCR法を用いたFLT3-ITDの検査にて偽陰性となった急性骨髄性白血病の2例(Two cases of acute myeloid leukemia that FLT3-ITD became false-negative in standard PCR method)

    阪口 正洋, 山口 博樹, 名島 悠峰, 鐘野 勝洋, 尾内 大志, 丸毛 淳史, 大森 郁子, 山中 聡, 藤原 裕介, 由井 俊輔, 岡部 雅弘, 脇田 知志, 岡本 宗雄, 荒井 邦仁, 北野 智章, 大橋 一輝, 猪口 孝一

    臨床血液   59 ( 9 )   1641 - 1641   2018.9

    　More details

    Language：English   Publisher：(一社)日本血液学会-東京事務局  

    researchmap

  • 同種造血幹細胞移植における肝障害合併の臨床的意義(Clinical significance of liver injury in the early phase after allogeneic HSCT)

    大森 郁子, 山口 博樹, 尾内 大志, 丸毛 淳史, 山中 聡, 阪口 正洋, 藤原 裕介, 由井 俊輔, 福永 景子, 了徳寺 剛, 平川 経晃, 岡部 雅弘, 脇田 知志, 玉井 勇人, 岡本 宗雄, 中山 一隆, 猪口 孝一

    臨床血液   59 ( 9 )   1681 - 1681   2018.9

    　More details

    Language：English   Publisher：(一社)日本血液学会-東京事務局  

    researchmap

  • 急性骨髄性白血病における微小残存病変としてのNPM1変異検出法の有用性(Usefulness of a NPM1 mutation detection for assessment of minimal residual disease in AML)

    伊達 健太, 丸毛 淳史, 久保山 まりか, 臼杵 憲祐, 賀古 真一, 内山 人二, 鐘野 勝洋, 名島 悠峰, 黒澤 彩子, 阪口 正洋, 由井 俊輔, 脇田 知志, 荒井 邦仁, 北野 智章, 垣花 和彦, 福田 隆浩, 大橋 一輝, 山口 博樹, 猪口 孝一

    臨床血液   59 ( 9 )   1617 - 1617   2018.9

    　More details

    Language：English   Publisher：(一社)日本血液学会-東京事務局  

    researchmap

  • RAS遺伝子経路変異陽性の急性骨髄性白血病の臨床的特徴(The clinical features of Japanese de novo AML with RAS signal transduction pathway genes mutation)

    由井 俊輔, 山口 博樹, 植木 俊充, 臼杵 憲祐, 小林 裕, 田近 賢二, 五味 聖二, 黒澤 彩子, 丸毛 淳史, 大森 郁子, 藤原 裕介, 阪口 正洋, 脇田 知志, 荒井 邦仁, 北野 智章, 福田 隆浩, 猪口 孝一

    臨床血液   59 ( 9 )   1616 - 1616   2018.9

    　More details

    Language：English   Publisher：(一社)日本血液学会-東京事務局  

    researchmap

  • Usefulness of BCOR gene mutation as a prognostic factor in acute myeloid leukemia with intermediate cytogenetic prognosis Reviewed

    Kazuki Terada, Hiroki Yamaguchi, Toshimitsu Ueki, Kensuke Usuki, Yutaka Kobayashi, Kenji Tajika, Seiji Gomi, Saiko Kurosawa, Riho Saito, Yutaka Furuta, Keiki Miyadera, Taichiro Tokura, Atsushi Marumo, Ikuko Omori, Masahiro Sakaguchi, Yusuke Fujiwara, Shunsuke Yui, Takeshi Ryotokuji, Kunihito Arai, Tomoaki Kitano, Satoshi Wakita, Takahiro Fukuda, Koiti Inokuchi

    Genes Chromosomes and Cancer   57 ( 8 )   401 - 408   2018.8

    　More details

    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Blackwell Publishing Inc.  

    BCOR gene is a transcription regulatory factor that plays an essential role in normal hematopoiesis. The wider introduction of next-generation sequencing technology has led to reports in recent years of mutations in the BCOR gene in acute myeloid leukemia (AML), but the related clinical characteristics and prognosis are not sufficiently understood. We investigated the clinical characteristics and prognosis of 377 de novo AML cases with BCOR or BCORL1 mutation. BCOR or BCORL1 gene mutations were found in 28 cases (7.4%). Among cases aged 65 years or below that were also FLT3-ITD-negative and in the intermediate cytogenetic prognosis group, BCOR or BCORL1 gene mutations were observed in 11% of cases (12 of 111 cases), and this group had significantly lower 5-year overall survival (OS) (13.6% vs. 55.0%, P = 0.0021) and relapse-free survival (RFS) (14.3% vs. 44.5%, P = 0.0168) compared to cases without BCOR or BCORL1 gene mutations. Multivariate analysis demonstrated that BCOR mutations were an independent unfavorable prognostic factor (P = 0.0038, P = 0.0463) for both OS and RFS. In cases of AML that are FLT3-ITD-negative, aged 65 years or below, and in the intermediate cytogenetic prognosis group, which are considered to have relatively favorable prognosis, BCOR gene mutations appear to be an important prognostic factor.

    DOI： 10.1002/gcc.22542

    Scopus

    PubMed

    researchmap

  • ホジキンリンパ腫(HL)発症後に特発性血小板減少性紫斑病(ITP)を合併した1例

    土蔵 太一朗, 中山 一隆, 尾内 大志, 朝山 敏夫, 由井 俊輔, 岡本 宗雄, 山口 博樹, 猪口 孝一

    臨床血液   59 ( 5 )   619 - 619   2018.5

    　More details

    Language：Japanese   Publisher：(一社)日本血液学会-東京事務局  

    researchmap

  • S条結腸がん術後に発症し急性増悪を来した非白血姓皮膚白血病

    由井俊輔, 藤原裕介, 横瀬紀夫, 猪口孝一

    臨床血液   59 ( 2 )   135   2018.2

    　More details

    Language：Japanese  

    researchmap

  • Full-length mutation search of the TP53 gene in acute myeloid leukemia has increased significance as a prognostic factor Reviewed

    Kazuki Terada, Hiroki Yamaguchi, Toshimitsu Ueki, Kensuke Usuki, Yutaka Kobayashi, Kenji Tajika, Seiji Gomi, Saiko Kurosawa, Keiki Miyadera, Taichiro Tokura, Ikuko Omori, Atushi Marumo, Yusuke Fujiwara, Shunsuke Yui, Takeshi Ryotokuji, Yoshiki Osaki, Kunihito Arai, Tomoaki Kitano, Fumiko Kosaka, Satoshi Wakita, Hayato Tamai, Takahiro Fukuda, Koiti Inokuchi

    Annals of Hematology   97 ( 1 )   51 - 61   2018.1

    　More details

    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Verlag  

    TP53 gene abnormality has been reported to be an unfavorable prognostic factor in acute myeloid leukemia (AML). However, almost all studies of TP53 gene abnormality so far have been limited to mutation searches in the DNA binding domain. As there have been few reports examining both mutation and deletion over the full-length of the TP53 gene, the clinical characteristics of TP53 gene abnormality have not yet been clearly established. In this study, TP53 gene mutation was observed in 7.3% of the total 412 de novo AML cases (33 mutations in 30 cases), with mutation outside the DNA binding domain in eight cases (27%). TP53 gene deletion was observed in 3.1% of 358 cases. All cases had monoallelic deletion with TP53 gene mutation on the opposite allele. Multivariate analysis demonstrated that TP53 gene mutation in the DNA binding domain and outside the DNA binding domain was an independent poor prognostic factor for overall survival and relapse-free survival among the total cohort and it is also an unfavorable prognostic factor in FLT3-ITD-negative AML cases aged 70 years or below with intermediate cytogenetic prognosis. In stratified treatment, full-length search for TP53 gene mutation is therefore very important.

    DOI： 10.1007/s00277-017-3143-2

    Scopus

    PubMed

    researchmap

  • A Case of Anti-Glomerular Basement Membrane Antibody-Positive Systemic Lupus Erythematosus with Pulmonary Hemorrhage Successfully Treated at an Early Stage of the Disease. Reviewed

    Yamada T, Mugishima K, Higo S, Yoshida Y, Itagaki F, Yui S, Kashiwagi T, Endo Y, Shimizu A, Tsuruoka S

    Journal of Nippon Medical School = Nippon Ika Daigaku zasshi   85 ( 2 )   138 - 144   2018

    　More details

  • 大量シタラビンでのMEAM療法を前処置とした自家末梢血幹細胞移植の成績

    由井俊輔, 山口博樹, 木下量介, 大森郁子, 丸毛淳史, 山中聡, 朝山敏夫, 藤原裕介, 福永景子, 栗林泰子, 了徳寺剛, 平川経晃, 岡部雅弘, 脇田知志, 玉井勇人, 守屋慶一, 岡本宗雄, 中山一隆, 猪口孝一

    日本造血細胞移植学会総会プログラム・抄録集   40th   295   2017.12

    　More details

    Language：Japanese  

    J-GLOBAL

    researchmap

  • D816 mutation of the KIT gene in core binding factor acute myeloid leukemia is associated with poorer prognosis than other KIT gene mutations Reviewed

    Shunsuke Yui, Saiko Kurosawa, Hiroki Yamaguchi, Heiwa Kanamori, Toshimitsu Ueki, Nobuhiko Uoshima, Ishikazu Mizuno, Katsuhiro Shono, Kensuke Usuki, Shigeru Chiba, Yukinori Nakamura, Masamitsu Yanada, Junya Kanda, Kenji Tajika, Seiji Gomi, Keiko Fukunaga, Satoshi Wakita, Takeshi Ryotokuji, Takahiro Fukuda, Koiti Inokuchi

    ANNALS OF HEMATOLOGY   96 ( 10 )   1641 - 1652   2017.10

    　More details

    Language：English   Publishing type：Research paper (scientific journal)   Publisher：SPRINGER  

    The clinical impact of KIT mutations in core binding factor acute myeloid leukemia (CBF-AML) is still unclear. In the present study, we analyzed the prognostic significance of each KIT mutation (D816, N822K, and other mutations) in Japanese patients with CBF-AML. We retrospectively analyzed 136 cases of CBF-AML that had gone into complete remission (CR). KIT mutations were found in 61 (45%) of the patients with CBF-AML. D816, N822K, D816 and N822K, and other mutations of the KIT gene were detected in 29 cases (21%), 20 cases (15%), 7 cases (5%), and 5 cases (4%), respectively. The rate of relapse-free survival (RFS) and overall survival (OS) in patients with D816 and with both D816 and N822K mutations was significantly lower than in patients with other or with no KIT mutations (RFS: p &lt; 0.001, OS: p &lt; 0.001). Moreover, stratified analysis of the chromosomal abnormalities t(8;21)(q22;q22) and inv(16)(p13.1q22), t(16;16)(p13.1;q22) showed that D816 mutation was associated with a significantly worse prognosis. In a further multivariate analysis of RFS and OS, D816 mutation was found to be an independent risk factor for significantly poorer prognosis. In the present study, we were able to establish that, of all KIT mutations, D816 mutation alone is an unfavorable prognostic factor.

    DOI： 10.1007/s00277-017-3074-y

    Web of Science

    PubMed

    researchmap

  • 急性骨髄性白血病における微少残存病変としてのNPM1変異高感度検出法の有用性(High sensitivity analysis of NPM1 mutation is useful for minimal residual disease in AML)

    Marumo Atsushi, Yamaguchi Hiroki, Yamanaka Satoshi, Fujiwara Yusuke, Terada Kazuki, Yui Shunsuke, Fukunaga Keiko, Ryotokuji Takeshi, Hirakawa Tsuneaki, Okabe Masahiro, Wakita Satoshi, Osaki Yoshiki, Arai Kunihito, Kitano Tomoaki, Kosaka Fumiko, Okamoto Muneo, Tamai Hayato, Nakayama Kazutaka, Inokuchi Koiti

    臨床血液   58 ( 9 )   1473 - 1473   2017.9

    　More details

    Language：English   Publisher：(一社)日本血液学会-東京事務局  

    researchmap

  • Amlexanox Downregulates S100A6 to Sensitize KMT2A/AFF1-Positive Acute Lymphoblastic Leukemia to TNFα Treatment. Reviewed

    Tamai H, Yamaguchi H, Miyake K, Takatori M, Kitano T, Yamanaka S, Yui S, Fukunaga K, Nakayama K, Inokuchi K

    Cancer research   77 ( 16 )   4426 - 4433   2017.8

    　More details

    Publishing type：Research paper (scientific journal)  

    Acute lymphoblastic leukemias (ALL) positive for KMT2A/ AFF1 (MLL/AF4) translocation, which constitute 60% of all infant ALL cases, have a poor prognosis even after allogeneic hematopoietic stem cell transplantation (allo-HSCT). This poor prognosis is due to one of two factors, either resistance to TNFα, which mediates a graft-versus-leukemia (GVL) response after allo-HSCT, or immune resistance due to upregulated expression of the immune escape factor S100A6. Here, we report an immune stimulatory effect against KMT2A/AFF1-positive ALL cells by treatment with the anti-allergy drug amlexanox, which we found to inhibit S100A6 expression in the presence of TNF-α. In KMT2A/AFF1-positive transgenic (Tg) mice, amlexanox enhanced tumor immunity and lowered the penetrance of leukemia development. Similarly, in a NOD/SCID mouse model of human KMT2A/AFF1-positive ALL, amlexanox broadened GVL responses and extended survival. Our findings show how amlexanox degrades the resistance of KMT2A/AFF1-positive ALL to TNFα by downregulating S100A6 expression, with immediate potential implications for improving clinical management of KMT2A/AFF1-positive ALL.

    DOI： 10.1158/0008-5472.CAN-16-2974

    Scopus

    PubMed

    researchmap

  • 当院で施行した自家末梢血幹細胞採取患者における採取幹細胞数の検討

    丸毛淳史, 平川経晃, 木下量介, 大森郁子, 山中聡, 藤原裕介, 由井俊輔, 福永景子, 了徳寺剛, 岡部雅弘, 脇田知志, 玉井勇人, 岡本宗雄, 中山一隆, 山口博樹, 猪口孝一

    日本造血細胞移植学会総会プログラム・抄録集   39th   264   2017.2

    　More details

    Language：Japanese  

    J-GLOBAL

    researchmap

  • 同種造血幹細胞移植に伴う肝障害の背景と予後

    大森郁子, 平川経晃, 山口博樹, 了徳寺剛, 藤原裕介, 丸毛敦史, 山中聡, 由井俊輔, 福永景子, 岡部雅弘, 脇田知志, 玉井勇人, 岡本宗雄, 中山一隆, 猪口孝一

    日本造血細胞移植学会総会プログラム・抄録集   39th   271   2017.2

    　More details

    Language：Japanese  

    J-GLOBAL

    researchmap

  • 短期メソトレキセート投与におけるロイコボリンレスキューが毒性軽減に与える影響

    平川経晃, 山口博樹, 了徳寺剛, 藤原裕介, 丸毛淳史, 大森郁子, 木下量介, 山中聡, 由井俊輔, 福永景子, 岡部雅弘, 脇田知志, 玉井勇人, 岡本宗雄, 中山一隆, 猪口孝一

    日本造血細胞移植学会総会プログラム・抄録集   39th   230   2017.2

    　More details

    Language：Japanese  

    J-GLOBAL

    researchmap

  • The Prognostic Impact of KIT D816 Mutations in Core Binding Factor Acute Myeloid Leukemia Reviewed

    Shunsuke Yui, Saiko Kurosawa, Hiroki Yamaguchi, Heiwa Kanamori, Toshimitsu Ueki, Nobuhiko Uoshima, Ishikazu Mizuno, Katsuhiro Shono, Kensuke Usuki, Yasushi Okoshi, Yukinori Nakamura, Masamitsu Yanada, Junya Kanda, Kenji Tajika, Seiji Gomi, Keiko Fukunaga, Satoshi Wakita, Takeshi Ryotokuji, Takahiro Fukuda, Koiti Inokuchi

    BLOOD   128 ( 22 )   2016.12

    　More details

    Language：English   Publisher：AMER SOC HEMATOLOGY  

    Web of Science

    researchmap

  • BCOR/BCORL1遺伝子変異を伴う急性骨髄性白血病の臨床的特徴と予後への影響(The clinical features and prognostic impact of acute myeloid leukemia with BCOR/BCORL1 gene mutation)

    Saito Riho, Yamaguchi Hiroki, Ueki Toshimitsu, Usuki Kensuke, Kobayashi Yutaka, Tajika Kenji, Gomi Seiji, Kurosawa Saiko, Furuta Yutaka, Tokura Taichiro, Miyadera Keiki, Yui Shunsuke, Fukunaga Keiko, Ryotokuji Takeshi, Osaki Yoshiki, Arai Kunihito, Kitano Tomoaki, Kosaka Fumiko, Terada Kazuki, Fukuda Takahiro, Inokuchi Koiti

    臨床血液   57 ( 9 )   1527 - 1527   2016.9

    　More details

    Language：English   Publisher：(一社)日本血液学会-東京事務局  

    researchmap

  • 急性骨髄性白血病の高齢患者における遺伝子変異の総合的分析(Comprehensive analysis of gene mutations in the elderly patients with acute myeloid leukemia)

    Fujiwara Yusuke, Yamaguchi Hiroki, Marumo Atsushi, Omori Ikuko, Yamanaka Satoshi, Terada Kazuki, Yui Shunsuke, Fukunaga Keiko, Ryotokuji Takeshi, Hirakawa Tsuneaki, Okabe Masahiro, Wakita Satoshi, Osaki Yoshiki, Arai Kunihito, Kitano Tomoaki, Kosaka Fumiko, Okamoto Muneo, Tamai Hayato, Nakayama Kazutaka, Inokuchi Koiti

    臨床血液   57 ( 9 )   1519 - 1519   2016.9

    　More details

    Language：English   Publisher：(一社)日本血液学会-東京事務局  

    researchmap

  • Clinical characteristics and prognosis of acute myeloid leukemia associated with DNA-methylation regulatory gene mutations Reviewed

    Takeshi Ryotokuji, Hiroki Yamaguchi, Toshimitsu Ueki, Kensuke Usuki, Saiko Kurosawa, Yutaka Kobayashi, Eri Kawata, Kenji Tajika, Seiji Gomi, Junya Kanda, Anna Kobayashi, Ikuko Omori, Atsushi Marumo, Yusuke Fujiwara, Shunsuke Yui, Kazuki Terada, Keiko Fukunaga, Tsuneaki Hirakawa, Kunihito Arai, Tomoaki Kitano, Fumiko Kosaka, Hayato Tamai, Kazutaka Nakayama, Satoshi Wakita, Takahiro Fukuda, Koiti Inokuchi

    HAEMATOLOGICA   101 ( 9 )   1074 - 1081   2016.9

    　More details

    Language：English   Publishing type：Research paper (scientific journal)   Publisher：FERRATA STORTI FOUNDATION  

    In recent years, it has been reported that the frequency of DNA-methylation regulatory gene mutations - mutations of the genes that regulate gene expression through DNA methylation - is high in acute myeloid leukemia. The objective of the present study was to elucidate the clinical characteristics and prognosis of acute myeloid leukemia with associated DNA-methylation regulatory gene mutation. We studied 308 patients with acute myeloid leukemia. DNA-methylation regulatory gene mutations were observed in 135 of the 308 cases (43.8%). Acute myeloid leukemia associated with a DNA-methylation regulatory gene mutation was more frequent in older patients (P&lt;0.0001) and in patients with intermediate cytogenetic risk (P&lt;0.0001) accompanied by a high white blood cell count (P=0.0032). DNA-methylation regulatory gene mutation was an unfavorable prognostic factor for overall survival in the whole cohort (P=0.0018), in patients aged &lt;= 70 years, in patients with intermediate cytogenetic risk, and in FLT3-ITD-negative patients (P=0.0409). Among the patients with DNA-methylation regulatory gene mutations, 26.7% were found to have two or more such mutations and prognosis worsened with increasing number of mutations. In multivariate analysis DNA-methylation regulatory gene mutation was an independent unfavorable prognostic factor for overall survival (P=0.0424). However, patients with a DNA-methylation regulatory gene mutation who underwent allogeneic stem cell transplantation in first remission had a significantly better prognosis than those who did not undergo such transplantation (P=0.0254). Our study establishes that DNA-methylation regulatory gene mutation is an important unfavorable prognostic factor in acute myeloid leukemia.

    DOI： 10.3324/haematol.2016.143073

    Web of Science

    PubMed

    researchmap

  • DNMT3AR882変異の高感度分析はAMLにおける微小残存病変に対し有用である(High sensitivity analysis of DNMT3AR882 mutation is useful for minimal residual disease in AML)

    Marumo Atsushi, Yamaguchi Hiroki, Omori Ikuko, Yamanaka Satoshi, Fujiwara Yusuke, Terada Kazuki, Yui Shunsuke, Fukunaga Keiko, Ryotokuji Takeshi, Hirakawa Tsuneaki, Okabe Masahiro, Wakita Satoshi, Arai Kunihito, Kitano Tomoaki, Kosaka Fumiko, Osaki Yoshiki, Tamai Hayato, Nakayama Kazutaka, Inokuchi Koiti

    臨床血液   57 ( 9 )   1528 - 1528   2016.9

    　More details

    Language：English   Publisher：(一社)日本血液学会-東京事務局  

    researchmap

  • Decision Analysis of Postremission Therapy in Cytogenetically Intermediate-Risk Acute Myeloid Leukemia: The Impact of FLT3 Internal Tandem Duplication, Nucleophosmin, and CCAAT/Enhancer Binding Protein Alpha. Reviewed

    Kurosawa S, Yamaguchi H, Yamaguchi T, Fukunaga K, Yui S, Wakita S, Kanamori H, Usuki K, Uoshima N, Yanada M, Shono K, Ueki T, Mizuno I, Yano S, Takeuchi J, Kanda J, Okamura H, Inamoto Y, Inokuchi K, Fukuda T

    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation   22 ( 6 )   1125 - 1132   2016.6

    　More details

  • Epstein-barr virus-positive T-cell lymphoproliferative disease following umbilical cord blood transplantation for acute myeloid leukemia Reviewed

    Shunsuke Yui, Hiroki Yamaguchi, Ken-Ichi Imadome, Ayako Arai, Mikiko Takahashi, Ryuji Ohashi, Hayato Tamai, Keiichi Moriya, Kazutaka Nakayama, Akira Shimizu, Koiti Inokuchi

    Journal of Nippon Medical School   83 ( 1 )   35 - 42   2016.3

    　More details

    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Medical Association of Nippon Medical School  

    We report a case of the extremely rare condition Epstein-Barr virus (EBV)-positive T-cell lymphoproliferative disease (LPD) which occurred after umbilical cord blood transplantation. A 25-year-old Japanese man underwent cord blood transplantation from a male human leukocyte antigen 4/6-matched donor due to acute myeloid leukemia with trisomy 8. Bone marrow examination on day 30 showed chimerism with at least 90% donor cells and complete hematological response. Chronic symptoms of graft-versushost disease appeared only on the skin and were successfully treated with cyclosporine alone. Three years later, however, the patient experienced repeated cold-like symptoms and was hospitalized with liver dysfunction. A high fever developed and was followed by significant edema of the right side of the face. The EBV DNA copy number in whole peripheral blood was 2×104/mL. Liver biopsy showed invasion of EBV-infected CD8-positive T cells. Southern blotting analysis of the whole peripheral blood showed that the T-cell receptor Cβ1 rearrangement was positive. On the basis of these results, EBVpositive T-cell LPD was diagnosed and treated with prednisolone, cyclosporine, and etoposide, followed by cyclophosphamide, doxorubicin, vincristine, and prednisone. However, the patient died of cardiac function failure, pneumonia, and pulmonary hemorrhage, all of unidentified cause. Most cases of EBVrelated LPD after hematopoietic stem cell transplantation consist of EBV-positive B-cell LPD, and, to our knowledge, de novo EBV-positive T-cell LPD subsequent to transplantation has not been previously reported.

    DOI： 10.1272/jnms.83.35

    Scopus

    PubMed

    researchmap

  • Complex molecular genetic abnormalities involving three or more genetic mutations are important prognostic factors for acute myeloid leukemia. Reviewed

    Wakita S, Yamaguchi H, Ueki T, Usuki K, Kurosawa S, Kobayashi Y, Kawata E, Tajika K, Gomi S, Koizumi M, Fujiwara Y, Yui S, Fukunaga K, Ryotokuji T, Hirakawa T, Arai K, Kitano T, Kosaka F, Tamai H, Nakayama K, Fukuda T, Inokuchi K

    Leukemia   30 ( 3 )   545 - 554   2016.3

    　More details

  • 造血器幹細胞移植に伴う非感染性呼吸器合併症の検討

    丸毛淳史, 山口博樹, 大森郁子, 山中聡, 藤原裕介, 由井俊輔, 福永景子, 了得寺剛, 平川経晃, 岡部雅弘, 脇田知志, 玉井勇人, 岡本宗雄, 中山一隆, 猪口孝一

    日本造血細胞移植学会総会プログラム・抄録集   38th   209   2016.2

    　More details

    Language：Japanese  

    J-GLOBAL

    researchmap

  • 血液造血器腫瘍に対する同種移植後のKDIGO分類によるAKIおよびCKD発症のリス因子および,腎組織像についての検討

    中山一隆, 山口博樹, 清水章, 三井亜希子, 玉井勇人, 岡本宗雄, 福永景子, 由井俊輔, 了徳時剛, 平川経晃, 岡部雅弘, 朝山敏夫, 小野寺麻加, 守屋慶一, 奥山奈美子, 濱田泰子, 脇田知志, 猪口孝一

    日本造血細胞移植学会総会プログラム・抄録集   38th   209   2016.2

    　More details

    Language：Japanese  

    J-GLOBAL

    researchmap

  • Epstein-Barr Virus-positive T-cell Lymphoproliferative Disease Following Umbilical Cord Blood Transplantation for Acute Myeloid Leukemia.

    Shunsuke Yui, Hiroki Yamaguchi, Ken-ichi Imadome, Ayako Arai, Mikiko Takahashi, Ryuji Ohashi, Hayato Tamai, Keiichi Moriya, Kazutaka Nakayama, Akira Shimizu, Koiti Inokuchi

    J Nippon Med Sch   83 ( 1 )   35 - 42   2016.2

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    We report a case of the extremely rare condition Epstein-Barr virus (EBV)-positive T-cell lymphoproliferative disease (LPD) which occurred after umbilical cord blood transplantation. A 25-year-old Japanese man underwent cord blood transplantation from a male human leukocyte antigen 4/6-matched donor due to acute myeloid leukemia with trisomy 8. Bone marrow examination on day 30 showed chimerism with at least 90% donor cells and complete hematological response. Chronic symptoms of graft-versus-host disease appeared only on the skin and were successfully treated with cyclosporine alone. Three years later, however, the patient experienced repeated cold-like symptoms and was hospitalized with liver dysfunction. A high fever developed and was followed by significant edema of the right side of the face. The EBV DNA copy number in whole peripheral blood was 2×10(4)/mL. Liver biopsy showed invasion of EBV-infected CD8-positive T cells. Southern blotting analysis of the whole peripheral blood showed that the T-cell receptor Cβ1 rearrangement was positive. On the basis of these results, EBV-positive T-cell LPD was diagnosed and treated with prednisolone, cyclosporine, and etoposide, follow

    DOI： 10.1272/jnms.83.35

    PubMed

    researchmap

  • The Therapeutic Outcomes of Mechanical Ventilation in Hematological Malignancy Patients with Respiratory Failure. Reviewed

    Fujiwara Y, Yamaguchi H, Kobayashi K, Marumo A, Omori I, Yamanaka S, Yui S, Fukunaga K, Ryotokuji T, Hirakawa T, Okabe M, Wakita S, Tamai H, Okamoto M, Nakayama K, Takeda S, Inokuchi K

    Internal medicine (Tokyo, Japan)   55 ( 12 )   1537 - 1545   2016

    　More details

  • 血液型不適合骨髄移植後の赤芽球瘻を発症しその後にEvans syndromeを合併した1例

    丸毛淳史, 中山一隆, 奥山奈美子, 小野寺麻加, 玉井勇人, 由井俊輔, 山口博樹, 猪口孝一

    臨床血液   56 ( 11 )   2360 - 2360   2015.11

    　More details

    Language：Japanese   Publisher：(一社)日本血液学会-東京事務局  

    J-GLOBAL

    researchmap

  • Clinical and genetic features of dyskeratosis congenita, cryptic dyskeratosis congenita, and Hoyeraal-Hreidarsson syndrome in Japan. Reviewed

    Yamaguchi H, Sakaguchi H, Yoshida K, Yabe M, Yabe H, Okuno Y, Muramatsu H, Takahashi Y, Yui S, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Inokuchi K, Ito E, Ogawa S, Kojima S

    International journal of hematology   102 ( 5 )   544 - 552   2015.11

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    Dyskeratosis congenita (DKC) is an inherited bone marrow failure (BMF) syndrome typified by reticulated skin pigmentation, nail dystrophy, and mucosal leukoplakia. Hoyeraal-Hreidarsson syndrome (HHS) is considered to be a severe form of DKC. Unconventional forms of DKC, which develop slowly in adulthood but without the physical anomalies characteristic of DKC (cryptic DKC), have been reported. Clinical and genetic features of DKC have been investigated in Caucasian, Black, and Hispanic populations, but not in Asian populations. The present study aimed to determine the clinical and genetic features of DKC, HHS, and cryptic DKC among Japanese patients. We analyzed 16 patients diagnosed with DKC, three patients with HHS, and 15 patients with cryptic DKC. We found that platelet count was significantly more depressed than neutrophil count or hemoglobin value in DKC patients, and identified DKC patients with large deletions in the telomerase reverse transcriptase and cryptic DKC patients with RTEL1 mutations on both alleles. This led to some patients previously considered to have unclassifiable BMF being diagnosed with cDKC through identification of new gene mutations. It thus seems important from a clinical viewpoint to re-examine the clinical characteristics, frequency of genetic mutations, and treatment efficacy in DKC, HHS, and cDKC.

    DOI： 10.1007/s12185-015-1861-6

    PubMed

    researchmap

  • TP53変異を有する急性骨髄性白血病の臨床的特徴(The clinical features of acute myeloid leukemia with TP53 mutation)

    Miyadera Keiki, Yamaguchi Hiroki, Ueki Toshimitsu, Usuki Kensuke, Kobayashi Yutaka, Tajika Kenji, Gomi Seiji, Kurosawa Saiko, Tokura Taichiro, Watanabe Makoto, Kobayashi Anna, Fujiwara Yusuke, Yui Shunsuke, Fukunaga Keiko, Wakita Satoshi, Hirakawa Tuneaki, Ryotokuji Takeshi, Arai Kunihito, Kitano Tomoaki, Kosaka Fumiko, Tamai Hayato, Fukuda Takahiro, Inokuchi Koiti

    臨床血液   56 ( 9 )   1454 - 1454   2015.9

    　More details

    Language：English   Publisher：(一社)日本血液学会-東京事務局  

    researchmap

  • RASシグナル伝達経路遺伝子の変異を有する日本人de novo AMLの臨床的特徴(The clinical features of Japanese de novo AML with RAS signal transduction pathway genes mutation)

    Yui Shunsuke, Yamaguchi Hiroki, Ueki Toshimitsu, Usuki Kensuke, Kobayashi Yutaka, Tajika Kenji, Gomi Seiji, Kurosawa Saiko, Fujiwara Yusuke, Fukunaga Keiko, Wakita Satoshi, Hirakawa Tsuneaki, Ryotokuji Takeshi, Arai Kunihito, Kitano Tomoaki, Kosaka Fumiko, Tamai Hayato, Fukuda Takahiro, Inokuchi Koiti

    臨床血液   56 ( 9 )   1454 - 1454   2015.9

    　More details

    Language：English   Publisher：(一社)日本血液学会-東京事務局  

    researchmap

  • 同種SCTを受けた難治性AML患者の臨床的および分子的特徴の解析(Analyses of clinical and molecular feature of refractory AML patients underwent allo-SCT)

    Fukunaga Keiko, Yamaguchi Hiroki, Wakita Satoshi, Fujiwara Yusuke, Yui Shunsuke, Rhotokuji Takeshi, Hirakawa Tsuneaki, Okabe Masahiro, Tamai Hayato, Arai Kunihito, Kitano Tomoaki, Kosaka Fumiko, Nakayama Kazutaka, Inokuchi Koiti

    臨床血液   56 ( 9 )   1725 - 1725   2015.9

    　More details

    Language：English   Publisher：(一社)日本血液学会-東京事務局  

    researchmap

  • 急性骨髄性白血病の高齢患者における遺伝子変異の解析(Analysis of genetic mutation of the elderly patients with acute myeloid leukemia)

    Fujiwara Yusuke, Wakita Satoshi, Yui Shunsuke, Fukunaga Keiko, Ryotokuji Takeshi, Hirakawa Tsuneaki, Okabe Masahiro, Tamai Hayato, Okamoto Muneo, Nakayama Kazutaka, Yamaguchi Hiroki, Inokuchi Koiti

    臨床血液   56 ( 9 )   1692 - 1692   2015.9

    　More details

    Language：English   Publisher：(一社)日本血液学会-東京事務局  

    researchmap

  • エピジェネティクス制御遺伝子変異を有するde novo AMLの臨床的および予後的特徴(The clinical and prognostic features of de novo AML with epigenetics regulative gene mutation)

    Ryotokuji Takeshi, Yamaguchi Hiroki, Ueki Toshimitsu, Usuki Kensuke, Kobayashi Yutaka, Tajika Kenji, Gomi Seiji, Kurosawa Saiko, Tokura Taichiro, Miyadera Keiki, Watanabe Makoto, Kobayashi Anna, Fujiwara Yusuke, Yui Shunsuke, Fukunaga Keiko, Wakita Satoshi, Hirakawa Tsuneaki, Arai Kunihito, Kitano Tomoaki, Kosaka Fumiko, Tamai Hayato, Fukuda Takahiro, Inokuchi Koiti

    臨床血液   56 ( 9 )   1537 - 1537   2015.9

    　More details

    Language：English   Publisher：(一社)日本血液学会-東京事務局  

    researchmap

  • MLL遺伝子異常を伴う急性骨髄性白血病の臨床像と予後への影響(The clinical features and prognostic impact of acute myeloid leukemia with MLL gene aberrations)

    Tokura Taichiro, Yamaguchi Hiroki, Ueki Toshimitsu, Usuki Kensuke, Kobayashi Yutaka, Tajika Kenji, Gomi Seiji, Kurosawa Saiko, Miyadera Keiki, Watanabe Makoto, Kobayashi Anna, Fujiwara Yusuke, Yui Shunsuke, Fukunaga Keiko, Wakaita Satoshi, Hirakawa Tuneaki, Ryotokuji Takeshi, Arai Kunihito, Kitano Tomoaki, Kosaka Fumiko, Tamai Hayato, Fukuda Takahiro, Inokuchi Koiti

    臨床血液   56 ( 9 )   1626 - 1626   2015.9

    　More details

    Language：English   Publisher：(一社)日本血液学会-東京事務局  

    researchmap

  • 複合遺伝子異常は急性骨髄性白血病の重要な予後因子である(Complex genetic abnormalities are important prognostic factors for acute myeloid leukemia)

    Wakita Satoshi, Yamaguchi Hiroki, Ueki Toshimitsu, Usuki Kensuke, Kobayashi Yutaka, Tajika Kenji, Gomi Seiji, Kurosawa Saiko, Tokura Taichiro, Watanabe Makoto, Kobayashi Anna, Fujiwara Yusuke, Yui Shunsuke, Fukunaga Keiko, Hirakawa Tuneaki, Ryotokuji Takeshi, Tamai Hayato, Arai Kunihito, Kitano Tomoaki, Kosaka Fumiko, Fukuda Takahiro, Inokuchi Koiti

    臨床血液   56 ( 9 )   1456 - 1456   2015.9

    　More details

    Language：English   Publisher：(一社)日本血液学会-東京事務局  

    researchmap

  • 血液造血器腫瘍に対する同種移植後のAKIおよびCKD発症のリスク因子および,腎組織像についての検討

    中山一隆, 山口博樹, 三井亜希子, 玉井勇人, 岡本宗雄, 福永景子, 由井俊輔, 藤原裕介, 平川経晃, 猪口孝一

    日本内科学会雑誌   104 ( Suppl. )   228 - 228   2015.2

    　More details

    Language：Japanese   Publisher：(一社)日本内科学会  

    J-GLOBAL

    researchmap

  • 当院における非寛解期急性骨髄性白血病に対する同種造血幹細胞移植の治療成績

    福永景子, 山口博樹, 藤原裕介, 由井俊輔, 了徳寺剛, 平川経晃, 岡部雅弘, 脇田知志, 玉井勇人, 岡本宗雄, 中山一隆, 猪口孝一

    日本造血細胞移植学会総会プログラム・抄録集   37th   293   2015.2

    　More details

    Language：Japanese  

    J-GLOBAL

    researchmap

  • 人工呼吸管理を必要とした呼吸不全合併造血幹細胞移植症例の予後と臨床的特徴

    藤原裕介, 山口博樹, 小林克也, 由井俊輔, 福永景子, 了徳寺剛, 平川経晃, 岡部雅弘, 脇田知志, 玉井勇人, 岡本宗雄, 中山一隆, 竹田晋浩, 猪口孝一

    日本造血細胞移植学会総会プログラム・抄録集   37th   308   2015.2

    　More details

    Language：Japanese  

    J-GLOBAL

    researchmap

  • 血液造血器腫瘍に対する同種移植後のAKIおよびCKD発症のリスク因子および,腎組織像についての検討

    中山一隆, 山口博樹, 三井亜希子, 玉井勇人, 福永景子, 由井俊輔, 了徳寺剛, 平川経晃, 岡部雅弘, 藤原裕介, 朝山敏夫, 小野寺麻加, 守屋慶一, 山中聡, 奥山奈美子, 濱田泰子, 岡本宗雄, 猪口孝一

    日本造血細胞移植学会総会プログラム・抄録集   37th   233   2015.2

    　More details

    Language：Japanese  

    J-GLOBAL

    researchmap

  • De novo AMLを有する日本人患者におけるPTPN11遺伝子変異の臨床的特徴(The clinical features of PTPN11 gene mutation in Japanese patients with de novo AML)

    Yui Shunsuke, Yamaguchi Hiroki, Usuki Kensuke, Kobayashi Yutaka, Tajika Kenji, Gomi Seiji, Kobayashi Anna, Watanabe Makoto, Azuma Kentaro, Sato Yuko, Todoroki Takahiro, Omori Ikuko, Fukunaga Keiko, Wakita Satoshi, Hirakawa Tsuneaki, Ryotokuji Takeshi, Arai Kunihito, Kitano Tomoaki, Kosaka Fumiko, Tamai Hayato, Inokuchi Koiti

    臨床血液   55 ( 9 )   1349 - 1349   2014.9

    　More details

    Language：English   Publisher：(一社)日本血液学会-東京事務局  

    researchmap

  • 細胞遺伝学的異常および遺伝学的異常がAMLの2回目のCR達成に及ぼす予後的影響(The prognostic impact of cytogenetic and genetic abnormality for the achievement of 2nd CR in AML)

    Fukunaga Keiko, Yamaguchi Hiroki, Wakita Satoshi, Omori Ikuko, Yui Shunsuke, Ryotokuji Takeshi, Hirakawa Tsuneaki, Arai Kunihito, Kitano Tomoaki, Kosaka Fumiko, Inokuchi Koiti

    臨床血液   55 ( 9 )   1351 - 1351   2014.9

    　More details

    Language：English   Publisher：(一社)日本血液学会-東京事務局  

    researchmap

  • 重症再生不良性貧血の治療

    山口 博樹, 由井 俊輔, 猪口 孝一

    血液内科   68 ( 5 )   599 - 608   2014.5

    　More details

    Language：Japanese  

    researchmap

  • 当院における重症再生不良性貧血9例の同種造血幹細胞移植成績

    由井俊輔, 山口博樹, 福永景子, 了徳寺剛, 平川経晃, 岡部雅弘, 脇田知志, 玉井勇人, 岡本宗雄, 中山一隆, 猪口孝一

    日本造血細胞移植学会総会プログラム・抄録集   36th   272   2014.2

    　More details

    Language：Japanese  

    J-GLOBAL

    researchmap

  • Test PK studyの結果を参考にivBU投与量を決定し前処置を施行した高度肥満を有するAML(M6)患者の一例

    中山一隆, 山口博樹, 松元加奈, 奥山奈美子, 朝山敏夫, 岡本宗雄, 福永景子, 守屋慶一, 浜田泰子, 藤原裕介, 由井俊輔, 玉井勇人, 脇田知志, 岡部雅弘, 平川経晃, 了徳寺剛, 近藤麻加, 森田邦彦, 猪口孝一, 山下卓也

    日本造血細胞移植学会総会プログラム・抄録集   36th   253   2014.2

    　More details

    Language：Japanese  

    J-GLOBAL

    researchmap

  • 重度再生不良性貧血に対するfludarabine含有前処置レジメンの実行可能性と有効性(Feasibility and efficacy of fludarabine-containing conditioning regimen for severe aplastic anemia)

    Nakayama Kazutaka, Yamaguchi Hiroki, Okabe Masahiro, Wakita Satoshi, Okamoto Muneo, Hirakawa Tsuneaki, Ryoutokuji Takeshi, Fukunaga Keiko, Yui Shunsuke, Tamai Hayato, Inokuchi Koichi

    臨床血液   54 ( 9 )   1477 - 1477   2013.9

    　More details

    Language：English   Publisher：(一社)日本血液学会-東京事務局  

    researchmap

  • 多項目自動血球分析装置XE‐5000による機械的破砕赤血球カウントを用いた移植後TMA診断の試み

    中山一隆, 常木美智子, 間宮一夫, 由井俊輔, 福永景子, 平川経晃, 岡本宗雄, 脇田知志, 岡部雅弘, 了徳寺剛, 玉井勇人, 竹内純子, 山口博樹, 猪口孝一, 檀和夫

    日本造血細胞移植学会総会プログラム・抄録集   35th   274   2013.2

    　More details

    Language：Japanese  

    J-GLOBAL

    researchmap

  • 自施設における悪性リンパ腫に対する造血幹細胞移植の治療成績

    平川経晃, 山口博樹, 由井俊輔, 浜田泰子, 福永景子, 了徳寺剛, 奥山奈美子, 岡部雅弘, 脇田知志, 玉井勇人, 中村純子, 近藤麻加, 守屋慶一, 岡本宗男, 中村弘之, 中村恭子, 中山一隆, 猪口孝一, 田近賢二, 檀和夫

    日本造血細胞移植学会総会プログラム・抄録集   35th   232   2013.2

    　More details

    Language：Japanese  

    J-GLOBAL

    researchmap

▼display all

Misc.

  • Taste disorders in patients undergoing hematopoietic stem cell transplantation

    斉藤芳徳, 外園卓也, 由井俊輔, 服部馨, 高澤理奈, 原田枝里, 土蔵太一, 脇田知志, 藤原裕介, 山中聡, 尾内大志, 砂川実香, 稲井一貴, 阪口正洋, 岡本宗雄, 久野彰子, 山口博樹, 猪口孝一

    日本造血細胞移植学会総会プログラム・抄録集   43rd   2021

    　More details

  • Clinical characteristics of noninfectious lung complication in allogenic stem cell transplantation

    朝山敏夫, 由井俊輔, 脇田知志, 永田安伸, 栗林泰子, 藤原裕介, 阪口正洋, 山中聡, 丸毛淳史, 大森郁子, 木下量介, 砂川実香, 海渡裕太, 尾内大志, 稲井一貴, 土蔵太一朗, 本間俊祐, 竹吉敦志, 保田駿一, 岡本宗雄, 猪口孝一, 山口博樹

    日本血液学会学術集会抄録(Web)   83rd   2021

    　More details

  • The clinical importance of DNMT3A, NPM1, and FLT3-ITD triple-mutation in Japanese AML

    板橋佳子, 阪口正洋, 由井俊輔, 翁家国, 賀古真一, 土岐典子, 諫田淳也, 森慎一郎, 佐竹敦志, 臼杵憲祐, 植木俊充, 魚嶋伸彦, 田近賢二, 鐘野勝洋, 田所治朗, 萩原政夫, 内山人二, 久保田寧, 黒田純也, 黒澤彩子, 橋本朗子, 本村小百合, 河田英里, 佐藤恵理子, 緒方正男, 三橋健次郎, 安藤純, 福田隆浩, 神田善伸, 山口博樹

    日本血液学会学術集会抄録(Web)   83rd   2021

    　More details

  • A case report of differential syndrome induced by gilteritinib in FLT3-ITD positive AML

    竹吉敦志, 丸毛淳史, 土蔵太一朗, 尾内大志, 阪口正洋, 由井俊輔, 永田安伸, 朝山敏夫, 脇田知志, 猪口孝一, 山口博樹

    日本血液学会学術集会抄録(Web)   83rd   2021

    　More details

  • FLT3-ITD陽性急性骨髄性白血病におけるDNAメチル化制御遺伝子変異とそのアレル比の臨床的意義

    神田真志, 脇田知志, 新井悠, 溝口歩, 黒沢明世, 阪口正洋, 由井俊輔, 臼杵憲祐, 植木俊充, 翁家国, 森慎一郎, 魚嶋伸彦, 小林裕, 賀古真一, 田近賢二, 鐘野勝洋, 萩原政夫, 諫田淳也, 内山人二, 黒田純也, 内田直之, 久保田寧, 黒澤彩子, 北野智章, 荒井邦仁, 荒井邦仁, 神田善伸, 大橋一輝, 福田隆浩, 山口博樹, 猪口孝一

    日本血液学会学術集会抄録(Web)   82nd   2020

    　More details

  • 無治療で自然軽快したびまん性大細胞型B細胞リンパ腫の一例

    尾内大志, 由井俊輔, 土蔵太一朗, 阪口正洋, 脇田知志, 岡本宗雄, 山口博樹, 猪口孝一

    日本血液学会学術集会抄録(Web)   82nd   2020

    　More details

  • Association between tongue wetness and oral mucositis in patients undergoing hematopoietic stem cell transplantation

    高澤理奈, 原田枝里, 服部馨, 久野彰子, 斎藤芳徳, 外園卓也, 阪口正洋, 土蔵太一郎, 稲井一貴, 砂川実香, 尾内大志, 山中聡, 藤原祐介, 脇田知志, 由井俊輔, 山口文子, 岡本宗雄, 山口博樹, 猪口孝一

    日本造血細胞移植学会総会プログラム・抄録集   42nd   2020

    　More details

  • Taste disorders in patients undergoing hematopoietic stem cell transplantation

    斎藤芳徳, 外薗卓也, 由井俊輔, 服部馨, 高澤理奈, 原田枝里, 土蔵太一朗, 脇田知志, 藤原裕介, 山中聡, 尾内大志, 砂川実香, 稲井一貴, 阪口正洋, 山口文子, 岡本宗雄, 久野彰子, 山口博樹, 猪口孝一

    日本造血細胞移植学会総会プログラム・抄録集   42nd   2020

    　More details

  • FLT3-ITD陽性急性骨髄性白血病におけるDNAメチル化制御遺伝子変異とそのアレル比の臨床的意義

    神田真志, 脇田知志, 新井悠, 溝口歩, 黒沢明世, 阪口正洋, 由井俊輔, 臼杵憲祐, 植木俊充, 翁家国, 森慎一郎, 魚嶋伸彦, 小林裕, 賀古真一, 田近賢二, 鐘野勝洋, 萩原政夫, 諫田淳也, 内山人二, 黒田純也, 内田直之, 久保田寧, 黒澤彩子, 北野智章, 荒井邦仁, 荒井邦仁, 神田善伸, 大橋一輝, 福田隆浩, 山口博樹, 猪口孝一

    日本血液学会学術集会抄録(Web)   82nd   2020

    　More details

  • Picture in Clinical Hematology No. 110

    由井 俊輔, 藤原 裕介, 横瀬 紀夫, 猪口 孝一

    臨床血液   59 ( 2 )   135 - 135   2018

    　More details

    Language：Japanese   Publisher：一般社団法人 日本血液学会  

    DOI： 10.11406/rinketsu.59.135

    researchmap

  • 高齢者de novo AMLに対する減量寛解導入療法"2+5"療法の試み

    尾内 大志, 中山 一隆, 岡本 宗雄, 守屋 慶一, 玉井 勇人, 岡部 雅弘, 平川 経晃, 栗林 泰子, 木下 量介, 阪口 正洋, 由井 俊輔, 朝山 敏夫, 大森 郁子, 丸毛 淳史, 山田 晃子, 海渡 裕太, 砂川 実香, 田村 秀人, 山口 博樹, 猪口 孝一

    老年者造血器疾患研究会会誌   25   12 - 12   2017.6

    　More details

    Language：Japanese   Publisher：老年者造血器疾患研究会  

    J-GLOBAL

    researchmap

  • Analysis of Genetic Mutation of the Elderly Patients with Acute Myeloid Leukemia

    Yusuke Fujiwara, Hiroki Yamaguchi, Atsushi Marumo, Ikuko Omori, Satoshi Yamanaka, Kazuki Terada, Shunsuke Yui, Keiko Fukunaga, Takeshi Ryotokuji, Tsuneaki Hirakawa, Masahiro Okabe, Satoshi Wakita, Yoshiki Osaki, Kunihito Arai, Tomoaki Kitano, Fumiko Kosaka, Hayato Tamai, Muneo Okamoto, Kazutaka Nakayama, Koiti Inokuchi

    BLOOD   128 ( 22 )   2016.12

    　More details

    Language：English   Publishing type：Research paper, summary (international conference)   Publisher：AMER SOC HEMATOLOGY  

    Web of Science

    researchmap

  • 前立腺肥大として発症し診断に苦慮した小型B細胞リンパ腫の1例

    瀬理祥, 藤原裕介, 由井俊輔, 横瀬紀夫, 猪口孝一

    臨床血液   57 ( 6 )   783(J‐STAGE) - 783   2016.6

    　More details

    Language：Japanese   Publisher：(一社)日本血液学会-東京事務局  

    J-GLOBAL

    researchmap

  • Decision Analysis of Allogeneic Hematopoietic Stem Cell Transplantation Versus Chemotherapy in Cytogenetically Standard-Risk Acute Myeloid Leukemia in First Complete Remission: The Impact of FLT3-ITD Profile

    Saiko Kurosawa, Hiroki Yamaguchi, Takuhiro Yamaguchi, Keiko Fukunaga, Shunsuke Yui, Heiwa Kanamori, Kensuke Usuki, Nobuhiko Uoshima, Masamitsu Yanada, Katsuhiro Shono, Toshimitsu Ueki, Ishikazu Mizuno, Shingo Yano, Jin Takeuchi, Junya Kanda, Hiroshi Okamura, Kinuko Tajima, Yoshihiro Inamoto, Koiti Inokuchi, Takahiro Fukuda

    BLOOD   124 ( 21 )   2014.12

    　More details

    Language：English   Publishing type：Research paper, summary (international conference)   Publisher：AMER SOC HEMATOLOGY  

    Web of Science

    researchmap

  • The Clinical and Genetic Features of Dyskeratosis Congenita, Cryptic Dyskeratosis Congenita, and Hoyeraal-Hreidarsson Syndrome in Japan

    Hiroki Yamaguchi, Hirotoshi Sakaguchi, Kenichi Yoshida, Miharu Yabe, Hiromasa Yabe, Yusuke Okuno, Hideki Muramatsu, Shunsuke Yui, Koiti Inokuchi, Etsuro Ito, Seishi Ogawa, Seiji Kojima

    BLOOD   124 ( 21 )   2014.12

    　More details

    Language：English   Publishing type：Research paper, summary (international conference)   Publisher：AMER SOC HEMATOLOGY  

    Web of Science

    researchmap

  • THE PROGNOSTIC IMPACT OF CYTOGENETIC AND GENETIC ABNORMALITY FOR THE ACHIEVEMENT OF THE SECOND COMPLETE REMISSION IN ADULT PATIENTS WITH ACUTE MYELOID LEUKEMIA

    K. Fukunaga, H. Yamaguchi, S. Wakita, I. Omori, S. Yui, T. Ryotokuji, T. Hirakawa, K. Arai, T. Kitano, F. Kosaka, K. Dan, K. Inokuchi

    HAEMATOLOGICA   99   300 - 300   2014.6

    　More details

    Language：English   Publishing type：Research paper, summary (international conference)   Publisher：FERRATA STORTI FOUNDATION  

    Web of Science

    researchmap

  • 多発性骨髄腫の病変評価におけるSPECT-CTの有用性

    守屋 慶一, 田村 秀人, 福嶋 善光, 石橋 真理子, 濱田 泰子, 奥山 奈美子, 近藤 麻加, 山田 晃子, 由井 俊輔, 汲田 伸一郎, 猪口 孝一

    International Journal of Myeloma   4 ( 2 )   91 - 91   2014.5

    　More details

    Language：Japanese   Publisher：日本骨髄腫学会  

    researchmap

▼display all