Updated on 2026/10/03

写真a

 
YUI KANAKO
 
Affiliation
Faculty of Medicine, Department of Medicine, Department of Legal Medicine, Assistant Professor
Title
Assistant Professor
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Research Interests

  • NMR

Research Areas

  • Life Science / Forensics medicine

  • Life Science / Neurosurgery

Education

  • 日本医科大学大学院   医学研究科生体制御再生医学領域   脳神経外科学分野

    2019.4 - 2024.6

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Research History

  • Nippon Medical School   Forensic Medicine   Assistant Professor

    2024.4

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  • Nippon Medical School   Neurosurgery   Assistant Professor

    2017.4 - 2024.3

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Professional Memberships

Papers

  • 皮質動脈の破裂によって引き起こされた急性硬膜下血腫の1剖検例(An autopsy case of acute subdural hematoma caused by rupture of a cortical artery)

    朝倉 久美子, 由井 奏子, 市川 実咲, 金涌 佳雅

    日本医科大学医学会雑誌   21 ( 4 )   416 - 416   2025.12

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    Language：English   Publisher：日本医科大学医学会  

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  • Time-frequency analysis reveals an association between the specific nuclear magnetic resonance (NMR) signal properties of serum samples and arteriosclerotic lesion progression in a diabetes mouse model

    Kanako Yui, Yoshimasa Kanawaku, Akio Morita, Keiko Hirakawa, Fanlai Cui

    PLOS ONE   2024.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    <jats:p>Diabetes causes arteriosclerosis, primarily due to persistent hyperglycemia, subsequently leading to various cardiovascular events. No method has been established for directly detecting and evaluating arteriosclerotic lesions from blood samples of diabetic patients, as the mechanism of arteriosclerotic lesion formation, which involves complex molecular biological processes, has not been elucidated. “NMR modal analysis” is a technology that enables visualization of specific nuclear magnetic resonance (NMR) signal properties of blood samples. We hypothesized that this technique could be used to identify changes in blood status associated with the progression of arteriosclerotic lesions in the context of diabetes. The study aimed to assess the possibility of early detection and evaluation of arteriosclerotic lesions by NMR modal analysis of serum samples from diabetes model mice. Diabetes model mice (BKS.Cg db/db) were bred in a clean room and fed a normal diet. Blood samples were collected and centrifuged. Carotid arteries were collected for histological examination by hematoxylin and eosin staining on weeks 10, 14, 18, 22, and 26. The serum was separated and subjected to NMR modal analysis and biochemical examination. Mice typically show hyperglycemia at an early stage (8 weeks old), and pathological findings of a previous study showed that more than half of mice had atheromatous plaques at 18 weeks old, and severe arteriosclerotic lesions were observed in almost all mice after 22 weeks. Partial least squares regression analysis was performed, which showed that the mice were clearly classified into two groups with positive and negative score values within 18 weeks of age. The findings of this study revealed that NMR modal properties of serum are associated with arteriosclerotic lesions. Thus, it may be worth exploring the possibility that the risk of cardiovascular events in diabetic patients could be assessed using serum samples.</jats:p>

    DOI： 10.1371/journal.pone.0299641

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Research Projects

  • 血清NMRモード解析による動脈硬化病変スクリーニング法開発の試み

    Grant number：25K18988  2025.4 - 2028.3

    日本学術振興会  科学研究費助成事業  若手研究

    由井 奏子

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    Grant amount：\4810000 （ Direct Cost: \3700000 、 Indirect Cost：\1110000 ）

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  • 最新の核磁気共鳴(ＮＭＲ)分析技術を用いた革新的な溺水吸引診断法への応用の試み

    Grant number：24K22213  2024.6 - 2027.3

    日本学術振興会  科学研究費助成事業  挑戦的研究(萌芽)

    崔 范来, 平川 慶子, 市川 実咲, 金涌 佳雅, 由井 奏子, 沖原 香

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    Grant amount：\6370000 （ Direct Cost: \4900000 、 Indirect Cost：\1470000 ）

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  • 複数のNMR分析技術による死後髄液からの同時複合的な法医診断法の開発

    Grant number：24K13556  2024.4 - 2027.3

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    金涌 佳雅, 平川 慶子, 市川 実咲, 崔 范来, 沖原 香, 由井 奏子

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    Grant amount：\4550000 （ Direct Cost: \3500000 、 Indirect Cost：\1050000 ）

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  • Development of a method for determining the cause of death from postmortem body fluid samples using NMR modal analysis

    Grant number：21K19676  2021.7 - 2025.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Research (Exploratory)

    Ichikawa Misaki

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    Grant amount：\6370000 （ Direct Cost: \4900000 、 Indirect Cost：\1470000 ）

    Postmortem cerebrospinal fluid collected during a forensic autopsy was subjected to nuclear magnetic resonance (NMR) measurement, followed by time-frequency analysis. The resulting spectrogram data were analysed using PLS-DA to verify the ability to identify or detect the presence of cranial trauma, pathological conditions, and postmortem interval. The results indicated the possibility of detecting the presence of cranial trauma and other factors derived from postmortem cerebrospinal fluid.Nevertheless, the spectrogram data obtained from this experiment was deemed to contain various biomedical information present in postmortem cerebrospinal fluid. It was therefore recognised that further research was necessary to develop a testing method that could be immediately utilised in forensic practice, given that the data may be influenced by drugs or other factors.

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  • Research on the application of qNMR method to forensic toxicological analysis

    Grant number：21K10534  2021.4 - 2025.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Kanawaku Yoshimasa

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    Grant amount：\4290000 （ Direct Cost: \3300000 、 Indirect Cost：\990000 ）

    A series of experiments were conducted using the qNMR method to ascertain the concentration of ascorbic acid solution. Ascorbic acid is a human endogenous substance and one of the components detected in blood. A comparative analysis was performed using high-performance liquid chromatography (HPLC) on the same sample. Following the optimisation of the measurement conditions for the qNMR method, it was determined that the NMR spectra of the ascorbic acid solution samples were obtained without incident under the prevailing measurement conditions.No impurity peaks that could potentially interfere with quantitative calculations were identified in the spectra. The correlation between the ascorbic acid concentrations quantified by qNMR and HPLC methods was found to be extremely good. In serum samples characterised by elevated levels of mixed components, it was determined that the successful extraction of peaks necessitates the application of expertise.

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Teaching Experience

  • 法医学

    2024.5
    Institution：日本医科大学

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