Language：Japanese   Publisher：(一社)日本耳科学会  

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Language：Japanese   Publisher：(一社)日本耳科学会  

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Language：Japanese   Publisher：(一社)日本めまい平衡医学会  

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Language：Japanese   Publisher：(一社)日本鼻科学会  

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Language：English   Publishing type：Research paper (scientific journal)  

PURPOSE: The status of dupilumab self-injection at home is not well understood. We therefore aimed to identify the barriers to adherence to dupilumab self-injection. PATIENTS AND METHODS: This non-interventional open-label study was conducted between March 2021 and July 2021. Patients with atopic dermatitis, bronchial asthma, and chronic rhinosinusitis with nasal polyps receiving dupilumab, from 15 sites, were requested to complete a self-administered questionnaire regarding the frequency and effectiveness of dosing as well as their use and satisfaction with dupilumab. Barriers to adherence were assessed using the Adherence Starts with Knowledge-12. RESULTS: We included 331 patients who used dupilumab for atopic dermatitis (n = 164), chronic rhinosinusitis with nasal polyps (n = 102), and bronchial asthma (n = 65). The median efficacy of dupilumab scored 9.3 on the visual analog scale. Overall, 85.5% of the patients self-injected dupilumab, and 70.7% perfectly complied with the established injection dates. The pre-filled pen was significantly superior to the conventional syringe in terms of usability, operability, ease of pushing the plunger, and patient satisfaction. However, the pre-filled pen caused more pain during self-injection than did the syringe. Multivariate logistic regression analysis showed that adherence decreased with longer dupilumab treatment duration (p = 0.017) and was not associated with age, sex, underlying disease, or device type. There was a difference in responses related to "inconvenience/forgetfulness" between the good and poor adherence groups. CONCLUSION: The pre-filled dupilumab pen was superior to the syringe in terms of usability, operability, ease of pushing the plunger, and satisfaction. Repetitive instructions are recommended for preventing poor adherence to dupilumab self-injection.

DOI： 10.2147/PPA.S389865

PubMed

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J-GLOBAL

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J-GLOBAL

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J-GLOBAL

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Language：Japanese   Publisher：(一社)日本アレルギー学会  

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Language：Japanese   Publisher：(株)医学書院  

65歳男性。咽頭痛、嚥下時違和感を主訴に当院へ受診となった。初診時、左口蓋扁桃下極を中心に、左口蓋扁桃上極から左梨状陥凹に至る腫瘍が認められ、同部は頸部MRI T2強調像にて高信号を示した。生検および全身検索の結果、p16陰性中咽頭癌(T3N2bM0)と診断され、DTX、CDDPと5-FUによる化学療法を2コース行ったのち、CDDP併用放射線療法が施行された。その結果、治療効果はCRであったが、治療終了9週後に治療関連骨髄異形成症候群を発症した。以後、予後不良が予測されたため積極的治療は行えず、治療終了24週後に死亡となった。

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Language：Japanese  

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Presentation type：Oral presentation (general)  

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