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DOI： 10.1016/j.jdermsci.2022.10.004

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Authorship：Corresponding author  

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Publishing type：Research paper (scientific journal)  

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Language：English   Publisher：日本医科大学医学会  

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Language：Japanese   Publisher：(一社)日本耳鼻咽喉科頭頸部外科学会  

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Medical Association of Nippon Medical School  

BACKGROUND: Cutaneous wound healing is a complex, dynamic physiological process. Traditional methods of promoting wound healing are not always effective. Consequently, alternative modalities, such as photodynamic therapy (PDT), are needed. We examined the effectiveness and underlying mechanisms of PDT in a murine model of acute wound healing. METHODS: Two excisional wounds were produced, one on each side of the midline, in C57bL/6J mice. Methyl 5-aminolevulinate hydrochloride (MAL) was applied to the right-side wound. After 1 to 3 hours of incubation, the wound was irradiated with red light. The left-side wound was not treated with MAL or red light. On Day 14, the wounds were excised and subjected to histological and immunohistochemical analysis. RESULTS: During the first week, no difference was seen between the two sides. However, at week 2, PDT-treated wounds exhibited delayed re-epithelialization. On Day 14, hematoxylin and eosin (HE) staining showed a continuous epithelial lining in untreated wounds. In contrast, PDT-treated wounds partially lacked epithelium in the wound bed. Masson's Trichrome (MTC) staining showed a thicker dermis and more collagen fibers and inflammatory cells in PDT-treated wounds than in untreated wounds. Immunohistochemical analyses showed significantly fewer CD31+ blood vessels and greater collagen III density in PDT-treated wounds than in untreated wounds. However, treated and untreated wounds did not differ in collagen I density. CONCLUSIONS: PDT delayed acute wound healing in a murine model of secondary intention wound healing.

DOI： 10.1272/jnms.jnms.2020_87-301

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DOI： 10.1097/PRS.0000000000006481

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Language：Japanese   Publisher：(一社)日本創傷治癒学会  

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Language：Japanese   Publisher：(一社)日本創傷治癒学会  

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：AMER CHEMICAL SOC  

Using a novel hydrogen peroxide heating method, we synthesized milky white, water-soluble polyhydroxylated fullerenes (fullerenols) with 36-40 hydroxyl groups (estimated average) along with 8-9 secondary bound water molecules. The fullerenols exhibited high water solubility up to 58.9 mg/mL in a neutral (pH = 7) condition. Dynamic light scattering analysis showed a high dispersion property, to give a narrow particle size distribution within 0.7-2.0 nm.

DOI： 10.1021/nn700151z

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：WILEY-LISS  

Objective. Studies have shown the roles of oxidative stress in the pathogenesis of osteoarthritis (OA) and induction of chondrocyte senescence during OA progression. The aim of this study was to examine the potential of a strong free-radical scavenger, water-soluble fullerene (C60), as a protective agent against catabolic stress-induced degeneration of articular cartilage in OA, both in vitro and in vivo.
Methods. In the presence or absence of C60 (100 mu M), human chondrocytes were incubated with interleukin-1 beta (10 ng/ml) or H2O2 (100 mu M, and chondrocyte activity was analyzed. An animal model of OA was produced in rabbits by resection of the medial meniscus and medial collateral ligament. Rabbits were divided into 5 subgroups: sham operation or treatment with C60 at 0.1 mu M, 1 mu M, 10 mu M, or 40 mu M. The left knee joint was injected intraarticularly with water-soluble C60 (2 ml), while, as a control, the right knee joint received 50% polyethylene glycol (2 ml), once weekly for 4 weeks or 8 weeks. Knee bone and cartilage tissue were prepared for histologic analysis. In addition, in the OA rabbit model, the effect of C60 (10 mu M) on degeneration of articular cartilage was compared with that of sodium hyaluronate (HA) (5 mg/ml).
Results. C60 (100 mu M) inhibited the catabolic stress-induced production of matrix-degrading enzymes (matrix metalloproteinases 1, 3, and 13), down-regulation of matrix production, and apoptosis and premature senescence in human chondrocytes in vitro. In rabbits with OA, treatment with water-soluble C60 significantly reduced articular cartilage degeneration, whereas control knee joints showed progression of cartilage degeneration with time. This inhibitory effect was dose dependent, and was superior to that of HA. Combined treatment with C60 and RA yielded a significant reduction in cartilage degeneration compared with either treatment alone.
Conclusion. The results indicate that C60 fullerene is a potential therapeutic agent for the protection of articular cartilage against progression of OA.

DOI： 10.1002/art.22917

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：TAYLOR & FRANCIS LTD  

We investigated the antioxidant activity of supramolecular water-soluble fullerenes, polyvinylpyrrolidone (PVP)-entrapped C-60, and gamma-cyclodextrin (CD)bicapped C-60, based on comparable beta-carotene bleaching assay. Antioxidant activity against reactive oxygen species (ROS) generated by three different methods, (i) autoxidation of linoleic acid, (ii) hydrogen peroxide promoter, and (iii) photoirradiation, was evaluated as percent of inhibition relative to a control experiment in view of the bleaching rate constant (k(obs)) as well as the persistent absorbancy of beta-carotene. Water-soluble fullerenes exhibit significant inhibitory effects on the oxidative discoloration of beta-carotene in any system.

DOI： 10.1271/bbb.60491

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：ELSEVIER IRELAND LTD  

Fullerenes characterized as an antioxidant are believed to reduce various reactive chemical species, such as free radicals, and their characteristic features have been disclosed to furnish many useful medical technologies. Despite the numerous applications for the biological efficacy of fullerenes, less is known about the toxicity of fullerenes in mammals. Hence, the protocol was designed to determine the acute oral median lethal dose and evaluate the acute toxicity of fullerenes when administrated as a single dose to Sprague-Dawley rats. In an acute toxicity test, fullerenes were administered once orally to a single group of male and female at a dose level of 2000 mg/kg. No deaths were observed and the body weights in both sexes of 2000 mg/kg group increased in a similar pattern to the control group. Genotoxicity of fullerenes was also assessed in a bacterial reverse mutation assay (Ames test) and the chromosomal aberration test in cultured Chinese hamster lung (CHL/IU) cells. Although structural chromosomal aberrations were induced at up to 5000 mu g/mL, there was no significant increase in the frequency of chromosomal aberrations at any dose level regardless of presence of S9. Fullerenes did not cause genetic damage in Salmonella typhimurium TA100, TA1535, TA98 and TA1537 and Escherichia coli WP2uvrA/pKM101. These results indicate that fullerenes are not of high toxicological significance. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

DOI： 10.1016/j.tox.2006.05.001

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：TAYLOR & FRANCIS INC  

We evaluated the inhibitory effect of water-soluble fullerene on UV-induced and the hydroperoxide t-BuOOH-induced apoptosis-like cell death against HaCaT cells. Pretreatment with polymer wrapped water-soluble fullerene, Radical Sponge (Vitamin C-60 BioResearch Corp., Tokyo, Japan), prevented the cell death, exhibiting anti-oxidant activity. We also assessed the effect of Radical Sponge in HMV-II human melanoma cells and NHEM normal human epidermal melanocytes. The results indicated that Radical Sponge affected melanogenesis in both human skin cells, displaying without any detectable cytotoxicity. We have found that Radical Sponge is endowed with a series of factors such as anti-oxidant ability and antimelanogenesis effect for juvenile skin protection.

DOI： 10.1080/15363830600665433

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：PERGAMON-ELSEVIER SCIENCE LTD  

Fullerene was entrapped in polyvinylpyrrolidone of 60-80 kDa at a molar ratio range of 0.42-0.67:1, resulting in a water-soluble derivative with a mean particle diameter of about 688 nm, named 'Radical Sponge(R)' because of its ROS-scavenging ability as previously demonstrated, and examined in the present study for its photo-biological actions toward human skin keratinocytes HaCaT. The keratinocytes were repeatedly irradiated with a visible light of wavelengths of 400-2000 nm (approximately 19,800 lux) in the presence or absence of Radical Sponge(R) of 25-75 mu M and did not exhibit any photo-cytotoxicity due to coexistent Radical Sponge(R) as compared with the sham-irradiation control. Radical Sponge(R) exerted a more marked cytoprotection at doses of 10-40 mu M against UVA irradiation of 30 J/cm(2) when it was pre-irradiationally administered and rinsed out immediately before the irradiation, than when administered only during or after the irradiation, indicating the preventive rather than therapeutic or ray-sheltering effect of Radical Sponge(R) on UVA injuries. Cytoprotection by Radical Sponge(R) against UVA was achieved at the advisable range doses of 10-40 mu M in contrast to no effect of polyvinylpyrrolidone alone; its dose-dependency was advantageous over that of VC-IP, a tetra-alkyl-esterized provitamin C, which became less cytoprotective above 20 mu M. Thus, Radical Sponge(R) is expected as an anti-UVA-preventive agent without visible-light-catalyzed cytotoxicity toward human skin keratinocytes. (C) 2005 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.bmcl.2005.12.011

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER  

Chemically generated hydroxyl radicals were scavenged by PEG-modified fullerene, hydroxy-fullerene and isostearate-mixed fullerene as efficiently as ascorbic acid (Asc) or its 2-O-phosphorylated derivative (A2P) as shown by the DMPO-spin trap/ESR method. Enzymatically generated superoxide anion radicals were also scavenged by PEG-modified or PVP-entrapped fullerene similarly as done by Asc or A2P. Some reactive oxygen species (ROS) such as hydroperoxides and hydrogen peroxides were generated preferably in the nuclei of UVB-irradiated human skin keratinocytes HaCaT, and repressed by PVP- or gamma-cyclodextrin-fullerene. In contrast, the cytoplasm in the keratinocytes accumulated the ROS that were generated by the peroxylipid model compound t-BuOOH, and underwent the ROS repression by PVP-fullerene more markedly than by A2P. Thus several fullerene derivatives, especially PVP-fullerene, were shown to diminish the ROS amounts in terms of the molecular and cellular levels against either UVB or t-BuOOH, suggesting the expectation for development as rejuvenation cosmetics. (c) 2005 Elsevier SAS. All rights reserved.

DOI： 10.1016/j.biopha.2005.02.004

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：TAYLOR & FRANCIS LTD  

The reaction of novel chiral selenonium and telluronium ylides was investigated with aldehydes and compared to the sulfur analogues. (2R,5R)-2,5-Dimethylselenolane was prepared and reacted as a catalyst for the benzylidenation of aldehydes, Disubstituted epoxides were readily prepared with a (surprising) absence of diastereoselectivity, and. with enantiomeric excesses higher than 90%. The reaction of a tellurium analogue, (2S,5S)-2,5-diethyltellurolane, afforded the oxirane in very moderate yield and e.e.'s in the range of 62-82%. Though this was less productive, it is the first report of a chiral telluronium ylide leading to an. asymmetric epoxidation of aldehydes.

DOI： 10.1080/10426500590905824

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：ROYAL SOC CHEMISTRY  

Amination of C H bonds activated by ether oxygen atoms is facile with chloramine-T as nitrene source and copper(I) chloride in acetonitrile as catalyst. For cyclic ethers the hemiaminal products are generally stable and can be isolated pure. For acyclic ethers, the hemiaminal products, as expected, fragment with elimination of alcohol to yield imines. When activation of benzylic positions is remote through a conjugated system, stable benzylamine derivatives are isolated. Mechanistic studies are consistent with concerted insertion of an electrophilic nitrenoid into the C-H bond in the rate-determining step, though in an asynchronous manner with a more activated substrate.

DOI： 10.1039/b410883c

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：ROYAL SOC CHEMISTRY  

Enantioenriched selenonium ylides have been generated by addition of benzyl bromide to C-2 symmetric (2R,5R)-2,5-dimethylselenolane in the presence of NaOH, and subsequently reacted with a variety of aldehydes to give oxiranes with excellent enantiomeric excesses (a catalytic version has been achieved); also, an aliphatic cyclic hypervalent dibromoselenurane structure has been demonstrated by X-ray analysis.

DOI： 10.1039/b106063p

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier  

Treatment of aryl benzyl selenides with [N-(p-toluenesulfonyl)imino]phenyliodinane [TsN=IPh] in the absence or presence of copper(I) salt in toluene or acetonitrile affords the corresponding N-tosylselenimides in 31-46% yield. When the reaction is carried out in the presence of optically active 4,4′-disubstituted bis(oxazoline) as a ligand together with molecular sieves, enantioselective imidation occurs to give optically active N-tosylselenimides and the best result is obtained from benzyl 2-naphthyl selenide (64% yield and 36% ee). Similar treatment of allylic selenides gives the corresponding optically active allylic amides (up to 71% yield and 30% ee). In the case of diastereoselective imidation, the reaction of diaryl selenides bearing a chiral oxazolinyl moiety with TsN=IPh or Chloramine-T trihydrate [TsN(Cl)Na·3H2O] has been successfully carried out to give the corresponding optically active N-tosylselenimides in good yields (up to 97% isolated yield and 76% de). The absolute configuration around the selenium atom of (4S)-Se-[2-(4-isopropyloxazolin-2-yl)phenyl]-Se-phenyl-N-(p-toluenesulfonyl) selenimide [(4S)-13], obtained by diastereoselective imidation of the corresponding selenide with Chloramine-T trihydrate, has been determined to be S by X-ray crystallographic analysis, from the result of which an ionic reaction pathway involving a chloroselenonium ion intermediate is proposed. © 2000 Elsevier Science S.A. All rights reserved.

DOI： 10.1016/S0022-328X(00)00488-5

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Language：English   Publishing type：Research paper (scientific journal)  

Enantioselective desymmetrization of meso-cyclic disulfides has been investigated on the basis of the desulfurization with chiral phosphines. Chiral tert-aminophosphines enable the desulfurization of a six-membered disulfide, cw-3,6-bis(alkoxycarbonyl)-1,2-dithiane 2, to give an enantiomerically enriched five-membered sulfide, trans-2,5-bis(alkoxycarbonyl)thiolane 5, with up to 36% ee. The desulfurization of a seven-membered disulfide, ds-3,7-bis(alkoxycarbonyl)-1,2-dithiepane 3, with chiral aminophosphines also gives a six-membered sulfide, trans-2,6-bis(alkoxycarbonyl)thiane 6, with up to 30% ee. © The Royal Society of Chemistry 2000.

DOI： 10.1039/b000191k

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：ROYAL SOC CHEMISTRY  

Enantioselective desymmetrization of meso-cyclic disulfides has been investigated on the basis of the desulfurization with chiral phosphines. Chiral tert-aminophosphines enable the desulfurization of a six-membered disulfide, cis-3,6-bis(alkoxycarbonyl)-1,2-dithiane 2, to give an enantiomerically enriched five-membered sulfide, trans-2,5-bis(alkoxycarbonyl)thiolane 5, with up to 36% ee. The desulfurization of a seven-membered disulfide, cis-3,7-bis(alkoxycarbonyl)-1,2-dithiepane 3, with chiral aminophosphines also gives a six-membered sulfide, trans-2,6-bis(alkoxycarbonyl)thiane 6, with up to 30% ee.

DOI： 10.1039/b000191k

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：WILEY-LISS  

The copper-catalyzed diastereoselective imidation of diaryl sulfides bearing a chiral oxazolinyl moiety at the ortho-position with [N-(p-toluenesulfonyl) imino]phenyliodinane (TsN=IPh) or Chloramine-T trihydrate [TsN(Cl)Na.3H(2)O] was successfully carried out to give the corresponding optically active N-tosylsulfimides in good yields. For example, the imidation of diphenyl sulfide bearing a methoxymethyl moiety at the 4-position of the oxazoline ring with TsN(Cl) Na.3H(2)O in acetonitrile in the presence of 10 mol% Cu(OTf)(2) at 25 degrees C for 24 h affords the corresponding optically active N-tosylsulfimide in 52% isolated yield with a high diastereoselectivity of 99%. Hydrolysis of the optically active N-p-tosylsulfimides converts them into the corresponding optically active sulfimides in high yields without loss of diastereoselectivity. These novel optically active sulfimides and N-tosylsulfimides work as efficient chiral ligands for palladium (II)-catalyzed allylic alkylation of 1,3-diphenyl-3-acetoxy-1-propene with dimethyl malonate to give the corresponding alkylation product quantitatively and with a high stereoselectivity (up to 90% ee). (C) 2000 Wiley-Liss, Inc.

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：ROYAL SOC CHEMISTRY  

Asymmetric intramolecular selenocyclisation of alkenoic acids, alkenols acid alkenyl urethanes using chiral 2-[1(dimethylamino)ethyl]ferrocenylselenenyl cations proceeds smoothly to give the corresponding organoselenenyl moiety-containing lactones, cyclic ethers and N-heterocycles, respectively, in good to excellent chemical yields (up to 97%) with very high diastereoselectivities (up to 98% de). The nature of the counter anions of the selenenylating agents affected remarkably the diastereoselectivity of the cyclisation, PF6- and BF4- being revealed to be the best for alkenoic acids and alkenols, and alkenyl urethanes, respectively A plausible reaction scheme for the cyclisation is presented where a chiral selenenylating agent approaches the carbon-carbon double bond of the substrate from the less sterically-congested direction to afford a chiral episelenonium ion followed by an intramolecular back side attack of a nucleophile.

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：GORDON BREACH SCI PUBL LTD  

A highly diastereoselective imidation (up to 91% de) of diaryl sulfides having a chiral oxazolinyl group at the ortho-position to the corresponding sulfimides has been achieved using TsN=IPh as a nitrene transfer reagent in the presence of Cu(OTf)(2) (10 mol%).

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：WILEY-V C H VERLAG GMBH  

DOI： 10.1002/(SICI)1521-3773(19990503)38:9<1288::AID-ANIE1288>3.0.CO;2-5

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：ROYAL SOC CHEMISTRY  

The direct catalytic imidation of various prochiral selenides with TsN=IPh in the presence of CuOTf using chiral 4,4'-disubstituted 2,2'-bis(oxazoline) ligand afforded the corresponding chiral selenimides(similar to 36% ee).

DOI： 10.1039/a803494j

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：ROYAL SOC CHEMISTRY  

lA direct catalytic sulfimidation of l,3-dithianes to the corresponding chiral monosulfimides with N-(p-tolylsulfonyl)imino(phenyl)iodinane (TsN=IPh) using a catalytic amount of copper(I) triflate (CuOTf) and a chiral 4,4'-disubstituted bis(oxazoline) as ligand has been developed. The reaction affords the chiral monosulfimides in good yield and with moderate enantioselectivity (up to 40% ee).

DOI： 10.1039/a802915f

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：GORDON BREACH PUBLISHING, TAYLOR & FRANCIS GROUP  

Asymmetric intramolecular selenocyclisation of alkenoic acids, alkenols and alkenyl urethanes using chiral ferrocenylselenenyl cations proceeds smoothly to give the corresponding lactones, cyclic ethers and N-heterocyclic compounds, respectively, in moderate yields with very high diastereoselectivities.

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：AMER CHEMICAL SOC  

A direct catalytic imidation of sulfides to sulfimides with [N-(p-tolylsulfonyl)imino]phenyliodinane (TsN=IPh) using a catalytic amount of copper triflate (CuOTf) has been developed. The reaction proceeds with a wide range of sulfides to give the corresponding sulfimides in 50-83% isolated yields. When the reaction is applied to allylic sulfides, the products are the corresponding sulfonamides produced via [2,3] sigmatropic rearrangement of the initially formed allylic sulfimides. In the presence of a chiral bis(oxazoline) as ligand, asymmetric induction occurs to afford the chiral sulfimides (up to 71% ee) and sulfonamides (up to 58% ee). Chloramine T (TsNClNa) can be used in place of TsN=IPh for asymmetric sulfimidation, but the ee's are much lower. Some mechanistic observations are described.

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：PERGAMON-ELSEVIER SCIENCE LTD  

Selenothioic acid S-alkyl esters were reacted with allylic bromides in the presence of Et3N. Mono-, di- or tri-allylated products were selectively formed by changing reaction temperatures. limes and allylic bromides used. The reaction proceeded with high regio- and stereoselectivity via the seleno-Claisen rearrangement. The selective synthesis of mono-allylated esters was also attained by the reaction of in-situ generated lithium eneselenolates with allylic bromides. (C) 1997 Elsevier Science Ltd.

DOI： 10.1016/S0040-4020(97)00556-5

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：AMER CHEMICAL SOC  

Selenothioic acid S-alkyl esters were synthesized from the reaction of terminal acetylenes with n-butyllithium, selenium, and alkanethiols in moderate to high yields. The use of substituted benzenethiols or (triphenylsilyl)-acetylene. allowed for the isolation of S-aryl esters, The synthesis of alpha-aryl selenothioic acid S-alkyl esters was attained by the acid-catalyzed reaction of selenoacetic acid Se-alkynyl esters with thiols in good yields. Se-77 NMR studies showed that the chemical shifts in a series of the esters were downfield of that in selenoester by about 500 ppm and were upfield of that in selenoketone by about 600 ppm, In the visible spectra the absorptions of the esters were observed at about 340 and 568 nm. X-ray molecular structure analyses of alpha-silyl esters showed that the bond distances in the selenocarbonyl group were 1.792 and 1.785 Angstrom, respectively, The formation of 1,3-diselenetane was confirmed from the decomposed products of S-phenyl ester. The trend for the stability of selenothioic acid S-esters is discussed on the basis of these synthetic results.

DOI： 10.1021/ja970462l

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：GORDON BREACH SCI PUBL LTD  

The synthesis and stability of selenothioic acid S-esters are discussed.

DOI： 10.1080/10426509708545533

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：GORDON BREACH SCI PUBL LTD  

Prochiral sulfides reacted with PhI=NTs in the presence of a catalytic amount of Cu(I) salt together with a chiral 4,4'-disubstituted bis(oxazoline) ligand to afford the corresponding chiral sulfimides.

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Taylor and Francis Ltd.  

The synthesis and stability of selenothioic acid S-esters are discussed.

DOI： 10.1080/10426509708545533

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Taylor and Francis Ltd.  

Prochiral sulfides reacted with PhI=NTs in the presence of a catalytic amount of Cu(I) salt together with a chiral 4,4′-disubstituted bis(oxazoline) ligand to afford the corresponding chiral sulfimides.

DOI： 10.1080/10426509708545550

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：ROYAL SOC CHEMISTRY  

Prochiral sulfides react with PhI=NTs in the presence of a catalytic amount of Cu-I salt together with chiral 4,4'-disubstituted bis(oxazoline) ligands to afford the corresponding chiral sulfimides.

DOI： 10.1039/cc9960000931

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：ROYAL SOC CHEMISTRY  

The chiral oxazolylferrocene-phosphine hybrid ligand (DIPOF) is a very effective ligand for Ir-I-catalysed asymmetric hydrosilylation of simple ketones to give the corresponding sec-alcohols (up to 96% ee) after acid hydrolysis.

DOI： 10.1039/cc9960000847

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：ROYAL SOC CHEMISTRY  

Asymmetric intramolecular selenocyclisation of alkenoic acids, alkenols and olefinic urethanes using chiral ferrocenylselenenyl cations proceeds smoothly to give the corresponding lactones, cyclic ethers and nitrogen-heterocyclic compounds, respectively, in moderate yields with very high diastereoselectivities.

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DOI： 10.1039/c39950002321

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：PERGAMON-ELSEVIER SCIENCE LTD  

The reaction of selenothioic acid S-alkyl esters with electron deficient alkynes was carried out under reflux in toluene to give cyclic selenides in good yields. On the contrary, the similar reaction in MeOH or CH2Cl2 with Et(3)N afforded acyclic divinyl selenides in good to high yields.

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Language：Japanese   Publisher：日本医科大学医学会  

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Language：Japanese   Publisher：(株)ニュー・サイエンス社  

肝臓などを除いて多くの臓器で組織再生が生じないヒトでは、臓器が傷ついた際、創傷治癒過程がおこる。創傷治癒の主体は、欠損部や壊死部が線維組織に置換され瘢痕が形成されるものである。体表面の創傷では、この線維組織である肉芽組織・瘢痕組織が外観上の問題だけでなく、機能的な瘢痕拘縮といった病態を引き起こす。従来この創傷治癒においては細胞や液性因子ばかりが注目されてきたが、リンパ液や血液などの細胞外液(Extracellular Fluid:ECF)や細胞外基質(Extracellular Matrix:ECM)を含む、細胞を取り巻く物理的環境が劇的に変化し、メカノセンシング機構が多分に関与していることがわかってきた。このメカニズムを利用して、創傷治癒を促進させる陰圧閉鎖治療や体外衝撃波治療などのメカノセラピーが臨床応用されはじめている。さらに詳細なメカノセンシング機構の解明が、新たな治療法の開発に役立つと考えられる。(著者抄録)

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Language：Japanese   Publisher：日本耳鼻咽喉科免疫アレルギー学会  

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Language：Japanese   Publisher：日本耳鼻咽喉科免疫アレルギー学会  

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Language：Japanese   Publisher：日本医科大学医学会  

J-GLOBAL

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Language：Japanese   Publisher：日本医科大学医学会  

J-GLOBAL

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Language：Japanese   Publisher：日本医科大学医学会  

J-GLOBAL

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Language：Japanese   Publisher：(一社)日本アレルギー学会  

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J-GLOBAL

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Language：Japanese   Publisher：COSMIC  

メカノバイオロジーは、張力や浸透圧といった物理的刺激が、細胞、組織、臓器あるいは生体にどのような影響を与えるかを解析する生物物理学の研究領域である。メカノバイオロジーの概念をもとにした医学研究はメカノメディシンと言われるが、これを実際の臨床現場で考え、物理的環境をコントロールする医療はメカノセラピーと呼ばれる。本論文では、メカノメディシンを臨床応用する具体的方法論、すなわちメカノセラピーの具体的方法につき考察する。(著者抄録)

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Language：Japanese   Publisher：日本医科大学医学会  

J-GLOBAL

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Language：Japanese  

CiNii Books

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Other Link： http://search.jamas.or.jp/link/ui/2016231121

Language：English   Publishing type：Research paper, summary (international conference)   Publisher：SPRINGER JAPAN KK  

Web of Science

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Language：English   Publishing type：Research paper, summary (international conference)   Publisher：AMER CHEMICAL SOC  

Web of Science

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Language：English   Publishing type：Research paper, summary (international conference)   Publisher：AMER CHEMICAL SOC  

Web of Science

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Language：English   Publisher：CHEMICAL SOC JAPAN  

Allylations of selenothioic acid S-alkyl esters with allylic bromides in the presence of Et(3)N in THF took place selectively at the or-position of selenocarbonyl group to give allylated products with high regio- and stereo-selectivity.

DOI： 10.1246/cl.1995.1057

Web of Science

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