2026/06/12 更新

写真a

クボムラ　ケン
久保村　憲
Kubomura Ken
所属
武蔵小杉病院 形成外科 病院講師
職名
病院講師
外部リンク

学位

  • 医学博士 （ 2023年3月   日本医科大学 ）

論文

  • Objective Odor Assessment in Patients with Osmidrosis. 国際誌

    Ken Kubomura, Rei Ogawa, Naori Sasaki, Shizuko Ichinose, Satoshi Akaishi, Hiroaki Kuwahara

    Plastic and reconstructive surgery. Global open   10 ( 10 )   e4622   2022年10月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    UNLABELLED: No standards for the assessment of axillary odor intensity and the effects of therapy for osmidrosis have been established. This study presents an objective method for assessing odor severity in patients with osmidrosis and investigates the volatile odorants and skin flora. METHODS: The odor intensity was measured pre- and postoperatively using an industrial odor sensor in 79 patients with osmidrosis. Cultures of the axillary skin were obtained during skin flap surgery. Volatile odorants of the patients were assessed using an odor-sensor gas chromatograph mass spectrometer, and samples collected from clothing worn by the patients before and after surgery. The skin pH of the axilla was measured before and after surgery. The locations of odorants and bacteria in the skin were observed using electron microscopy. RESULTS: The mean patient age was 28.8 years, and the male-to-female ratio was 4:3. The odor significantly decreased from 52.6 preoperatively to 20.5 postoperatively (P < 0.001). The bacterial flora on the skin included mostly Staphylococcus. Multiple causative substances (volatile proteins) were identified on gas chromatography. The mean preoperative axillary skin pH was 6.21, which was significantly different than that of patients without osmidrosis (5.92; P < 0.01). CONCLUSIONS: An odor sensor accurately assesses odor intensity in patients with osmidrosis. The neutralization of axillary pH may promote the production of odorants by creating the optimal pH for bacterial growth. Odor sensor and pH values can be used pre- and postoperatively as objective assessment measurements for patients with osmidrosis.

    DOI： 10.1097/GOX.0000000000004622

    PubMed

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  • Extension of flaps associated with burn scar reconstruction: A key difference between island and skin-pedicled flaps 査読

    Yukiko Yoshino, Ken Kubomura, Hyakuzoh Ueda, Takuya Tsuge, Rei Ogawa

    BURNS   44 ( 3 )   683 - 691   2018年5月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：ELSEVIER SCI LTD  

    Objective: The choice between local flap designs for burn reconstruction is largely shaped by aesthetic, vascularity, procedural complexity, and wound-closure considerations. However, another key consideration is how well specific local flap designs release post-burn scar contractures. This is because constant tension on wound edges can generate pathological scarring. However, the ability of specific local flap to release post-burn scar contractures is poorly understood. This question was addressed by this study of patients who underwent local flap surgery to release post-burn scar contractures.Methods: The flap type, its original size, and the degree to which the flap extended 6 months after surgery were recorded.Results: Of the 40 patients enrolled, 20 received an island flap and 20 received a skin-pedicled flap. The scars were most commonly located on the anterior chest, axilla, and cubital fossa, followed by the lateral chest, abdomen, thigh, and popliteal fossa. Six months after surgery, the skin-pedicled and island flaps had extended on average by 1.53-and 1.28-fold, respectively.Conclusions: While it was technically easier to transfer island flaps to the recipient site, they released contractures less effectively than skin-pedicled flaps. The postoperative extensibility of flaps should be considered when determining which flap design is optimal for the individual patient. (C) 2017 Elsevier Ltd and ISBI. All rights reserved.

    DOI： 10.1016/j.burns.2017.09.016

    Web of Science

    Scopus

    PubMed

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  • Periauricular Keloids on Face-Lift Scars in a Patient with Facial Nerve Paralysis. 査読 国際誌

    Masayo Aoki, Satoshi Akaishi, Noriko M Matsumoto, Takuya Tsuge, Ken Kubomura, Midori Nishikawa, Shunichi Nomoto, Rei Ogawa

    Plastic and reconstructive surgery. Global open   5 ( 7 )   e1417   2017年7月

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    記述言語：英語  

    Keloids are caused by excessive scar formation that leads to scar growth beyond the initial scar boundaries. Keloid formation and progression is promoted by mechanical stress such as skin stretch force. Consequently, keloids rarely occur in paralyzed areas and areas with little skin tension, such as the periauricular region. Therefore, periauricular incision is commonly performed for face lifts. We report a rare case of keloids that arose from face-lift scars in a patient with bilateral facial nerve paralysis. A 51-year-old Japanese man presented with abnormal proliferative skin masses in bilateral periauricular scars. Seventeen years before, he had a cerebral infarction that resulted in permanent bilateral facial nerve paralysis. Three years before presentation, the patient underwent face-lift surgery with periauricular incisions. We diagnosed multiple keloids. We removed the masses surgically, closed the wounds with sutures in the superficial musculoaponeurotic system layer to reduce tension on the wound edges, reconstructed the earlobes with local skin flaps, and provided 2 consecutive days of radiotherapy. The wounds/scars were managed with steroid plasters and injections. Histology confirmed that the lesions were keloids. Ten months after surgery, the lesions did not exhibit marked regrowth. The keloids appeared to be caused by the patient's helmet, worn during his 3-hour daily motorcycle rides, which placed repeated tension on the periauricular area. This rare case illustrates how physical force contributes to auricular and periauricular keloid development and progression. It also shows that when performing surgery with periauricular incisions, care should be taken to eliminate wound/scar stretching.

    DOI： 10.1097/GOX.0000000000001417

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MISC

▼全件表示

共同研究・競争的資金等の研究課題

  • 腋臭症における腋臭発生メカニズムの分子生物学的解明

    研究課題/領域番号：25K18764  2025年4月 - 2027年3月

    日本学術振興会  科学研究費助成事業  若手研究

    久保村 憲

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    配分額：4810000円 （ 直接経費：3700000円 、 間接経費：1110000円 ）

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  • ABCC11遺伝子1塩基多形に基づく腋窩環境が及ぼす細菌叢と臭気強度に関する研究

    研究課題/領域番号：22K09871  2022年4月 - 2025年3月

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    桑原 大彰, 久保村 憲

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    配分額：1820000円 （ 直接経費：1400000円 、 間接経費：420000円 ）

    本研究では、腋臭症の客観的診断法と治療選択の最適化を目的に、ABCC11遺伝子の一塩基多型（SNP）、腋窩pH、皮膚常在細菌叢の解析を216名に実施した。腋臭の強度や術前後の腋窩環境の変化と明確な相関が示され、診断や治療適応の客観的指標としての有用性が確認された。特に自己臭恐怖症との鑑別における遺伝子情報と局所環境の評価意義は重要であり、得られた成果は腋臭症の科学的理解と非侵襲的診療の発展に貢献すると期待される。

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