Updated on 2025/08/12

写真a

 
Ando Takahiro
 
Affiliation
Nippon Medical School Hospital, Department of Radiology, Assistant Professor
Title
Assistant Professor
External link

Research Areas

  • Life Science / Radiological sciences

Papers

  • Measurement of Turbulent Kinetic Energy in Hypertrophic Cardiomyopathy Using Triple-velocity Encoding 4D Flow MR Imaging.

    Kotomi Iwata, Tetsuro Sekine, Junya Matsuda, Masaki Tachi, Yoichi Imori, Yasuo Amano, Takahiro Ando, Makoto Obara, Gerard Crelier, Masashi Ogawa, Hitoshi Takano, Shinichiro Kumita

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   23 ( 1 )   39 - 48   2022.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    PURPOSE: The turbulent kinetic energy (TKE) estimation based on 4D flow MRI has been currently developed and can be used to estimate the pressure gradient. The objective of this study was to validate the clinical value of 4D flow-based TKE measurement in patients with hypertrophic cardiomyopathy (HCM). METHODS: From April 2018 to March 2019, we recruited 28 patients with HCM. Based on echocardiography, they were divided into obstructed HCM (HOCM) and non-obstructed HCM (HNCM). Triple-velocity encoding 4D flow MRI was performed. The volume-of-interest from the left ventricle to the aortic arch was drawn semi-automatically. We defined peak turbulent kinetic energy (TKEpeak) as the highest TKE phase in all cardiac phases. RESULTS: TKEpeak was significantly higher in HOCM than in HNCM (14.83 ± 3.91 vs. 7.11 ± 3.60 mJ, P < 0.001). TKEpeak was significantly higher in patients with systolic anterior movement (SAM) than in those without SAM (15.60 ± 3.96 vs. 7.44 ± 3.29 mJ, P < 0.001). Left ventricular (LV) mass increased proportionally with TKEpeak (P = 0.012, r = 0.466). When only the asymptomatic patients were extracted, a stronger correlation was observed (P = 0.001, r = 0.842). CONCLUSION: TKE measurement based on 4D flow MRI can detect the flow alteration induced by systolic flow jet and LV outflow tract geometry, such as SAM in patients with HOCM. The elevated TKE is correlated with increasing LV mass. This indicates that increasing cardiac load, by pressure loss due to turbulence, induces progression of LV hypertrophy, which leads to a worse prognosis.

    DOI: 10.2463/mrms.mp.2022-0051

    PubMed

    researchmap

  • Factors Influencing Long-Term Blood Flow in Extracranial-to-Intracranial Bypass for Symptomatic Internal Carotid Artery Occlusive Disease: A Quantitative Study. International journal

    Yasuo Murai, Tetsuro Sekine, Eitaro Ishisaka, Atsushi Tsukiyama, Asami Kubota, Fumihiro Matano, Takahiro Ando, Ryuta Nakae, Akio Morita

    Neurosurgery   90 ( 4 )   426 - 433   2022.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND: Maintaining the patency of extracranial-to-intracranial (EC-IC) bypass is critical for long-term stroke prevention. However, reports on the factors influencing long-term bypass patency and quantitative assessments of bypass patency are limited. OBJECTIVE: To quantitatively evaluate blood flow in EC-IC bypass using four-dimensional (4D) flow magnetic resonance imaging (MRI) and investigate factors influencing the long-term patency of EC-IC bypass. METHODS: Thirty-six adult Japanese patients who underwent EC-IC bypass for symptomatic internal carotid or middle cerebral artery occlusive disease were included. We examined the relationships between decreased superficial temporal artery (STA) blood flow volume and perioperative complications, long-term ischemic complications, patient background, and postoperative antithrombotic medications in patients for whom STA flow could be quantitatively assessed for at least 5 months using 4D flow MRI. RESULTS: The mean follow-up time was 54.7 ± 6.1 months. One patient presented with a stroke during the acute postoperative period that affected postoperative outcomes. No recurrent strokes were recorded during long-term follow-up. Two patients died of malignant disease. Seven cases of reduced flow occurred in the STA, which were correlated with single bypass (P = .0294) and nonuse of cilostazol (P = .0294). STA occlusion was observed in 1 patient during the follow-up period. Hypertension, age, smoking, dyslipidemia, and diabetes mellitus were not correlated with reduced blood flow in the STA. CONCLUSION: Double anastomoses and cilostazol resulted in long-term STA blood flow preservation. No recurrence of cerebral infarction was noted in either STA hypoperfusion or occlusion cases.

    DOI: 10.1227/NEU.0000000000001846

    PubMed

    researchmap

  • 4D Flow MR Imaging of the Left Atrium: What is Non-physiological Blood Flow in the Cardiac System?

    Tetsuro Sekine, Masatoki Nakaza, Mitsuo Matsumoto, Takahiro Ando, Tatsuya Inoue, Shun-Ichiro Sakamoto, Mitsunori Maruyama, Makoto Obara, Olgierd Leonowicz, Jitsuo Usuda, Shinichiro Kumita

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   21 ( 2 )   293 - 308   2022.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Most cardiac diseases cause a non-physiological blood flow pattern known as turbulence around the heart and great vessels, which further worsen the disease itself. However, there is no consensus on how blood flow can be defined in disease conditions. Especially, in the left atrium, the fact that vortex flow already exists makes this debate more complicated. 3D time-resolved phase-contrast (4D flow) MRI is expected to be able to capture blood flow patterns from multiple aspects, such as blood flow velocity, stasis, and vortex quantification. Previous studies have confirmed that physiological vortex flow is predominantly induced by the higher-volume flow from the superior left pulmonary vein. In atrial fibrillation, 4D flow MRI reveals a non-physiological blood flow pattern, which information may add value to well-established clinical risk factors. Currently, the research target of LA analysis has also widened to lung surgeons, pulmonary vein stump thrombosis after left upper lobectomy. 4D flow MRI is expected to be utilized for many more variable diseases that are currently unimaginable.

    DOI: 10.2463/mrms.rev.2021-0137

    PubMed

    researchmap

  • Dual-VENC 4D Flow MRI Can Detect Abnormal Blood Flow in the Left Atrium That Potentially Causes Thrombosis Formation after Left Upper Lobectomy

    Masatoki Nakaza, Mitsuo Matsumoto, Tetsuro Sekine, Tatsuya Inoue, Takahiro Ando, Masashi Ogawa, Makoto Obara, Olgierd Leonowicz, Shinichiro Kumita, Jitsuo Usuda

    Magnetic Resonance in Medical Sciences   21 ( 3 )   433 - 443   2022

     More details

    Publishing type:Research paper (scientific journal)   Publisher:Japanese Society for Magnetic Resonance in Medicine  

    DOI: 10.2463/mrms.mp.2020-0170

    researchmap

  • Utility of 4D Flow MRI in Thoracic Aortic Diseases: A Literature Review of Clinical Applications and Current Evidence

    Kenichiro Takahashi, Tetsuro Sekine, Takahiro Ando, Yosuke Ishii, Shinichiro Kumita

    Magnetic Resonance in Medical Sciences   21 ( 2 )   327 - 339   2022

     More details

    Publishing type:Research paper (scientific journal)   Publisher:Japanese Society for Magnetic Resonance in Medicine  

    DOI: 10.2463/mrms.rev.2021-0046

    researchmap

  • Cross-Comparison of 4-Dimensional Flow Magnetic Resonance Imaging and Intraoperative Middle Cerebral Artery Pressure Measurements Before and After Superficial Temporal Artery-Middle Cerebral Artery Bypass Surgery

    Tetsuro Sekine, Yasuo Murai, Erika Orita, Takahiro Ando, Ryo Takagi, Yasuo Amano, Fumihiro Matano, Kotomi Iwata, Masashi Ogawa, Makoto Obara, Shinichiro Kumita

    Neurosurgery   89 ( 5 )   909 - 916   2021.8

     More details

    Publishing type:Research paper (scientific journal)   Publisher:Ovid Technologies (Wolters Kluwer Health)  

    Abstract

    BACKGROUND

    The hemodynamic changes after superficial temporal artery (STA) to middle cerebral artery (MCA) bypass surgery are unclear.

    OBJECTIVE

    To clarify the hemodynamics by comparing flow parameters obtained by 4-dimensional (4D) flow magnetic resonance imaging (MRI) and intraoperative MCA pressure measurement.

    METHODS

    We recruited 23 patients who underwent STA-MCA bypass surgery for internal carotid artery (ICA) or MCA stenosis. We monitored intraoperative MCA, STA, and radial artery (RA) pressure. All patients underwent 4D flow MRI preoperatively and 3 wk after surgery to quantify the blood flow volume (BFV) of the ipsilateral ICA (BFViICA), contralateral ICA (BFVcICA), basilar artery (BFVBA), ipsilateral STA (BFViSTA), and contralateral STA (BFVcSTA). The sum of intracranial BFV was defined as BFVtotal. We compared BFV parameters and intraoperative pressure.

    RESULTS

    BFViSTA significantly increased after surgery (P &lt; .001). BFViICA and BFVBA significantly decreased after surgery (BFViICA P = .005; BFVBA P = .02). No significant difference was observed between BFVcICA before and after surgery. As a result, BFVtotal postoperatively increased by 6.8%; however, no significant difference was observed. Flow direction at M1 changed from antegrade to unclear after surgery in 5 patients. Intraoperative MCA pressure and MCA/RA pressure ratio significantly increased after surgery (P &lt; .001). We found a stronger positive correlation between MCA pressure increase ratio and BFVtotal increase ratio in patients with lower pre-MCA pressure (r = 0.907, P &lt; .001).

    CONCLUSION

    The visual and quantitative assessment of 4D flow MRI revealed that intracranial blood flow changes complementarily after STA-MCA bypass surgery. 4D flow MRI may detect the improvement of cerebral perfusion pressure.

    DOI: 10.1093/neuros/nyab305

    researchmap

    Other Link: https://journals.lww.com/10.1093/neuros/nyab305

  • Zero Echo Time MRAC on FDG-PET/MR Maintains Diagnostic Accuracy for Alzheimer’s Disease; A Simulation Study Combining ADNI-Data

    Takahiro Ando, Bradley Kemp, Geoffrey Warnock, Tetsuro Sekine, Sandeep Kaushik, Florian Wiesinger, Gaspar Delso

    Frontiers in Neuroscience   14   2020.11

     More details

    Publishing type:Research paper (scientific journal)   Publisher:Frontiers Media SA  

    Aim

    Attenuation correction using zero-echo time (ZTE) – magnetic resonance imaging (MRI) (ZTE-MRAC) has become one of the standard methods for brain-positron emission tomography (PET) on commercial PET/MR scanners. Although the accuracy of the net tracer-uptake quantification based on ZTE-MRAC has been validated, that of the diagnosis for dementia has not yet been clarified, especially in terms of automated statistical analysis. The aim of this study was to clarify the impact of ZTE-MRAC on the diagnosis of Alzheimer’s disease (AD) by performing simulation study.

    Methods

    We recruited 27 subjects, who underwent both PET/computed tomography (CT) and PET/MR (GE SIGNA) examinations. Additionally, we extracted 107 subjects from the Alzheimer Disease Neuroimaging Initiative (ADNI) dataset. From the PET raw data acquired on PET/MR, three FDG-PET series were generated, using two vendor-provided MRAC methods (ZTE and Atlas) and CT-based AC. Following spatial normalization to Montreal Neurological Institute (MNI) space, we calculated each patient’s specific error maps, which correspond to the difference between the PET image corrected using the CTAC method and the PET images corrected using the MRAC methods. To simulate PET maps as if ADNI data had been corrected using MRAC methods, we multiplied each of these 27 error maps with each of the 107 ADNI cases in MNI space. To evaluate the probability of AD in each resulting image, we calculated a cumulative t-value using a fully automated method which had been validated not only in the original ADNI dataset but several multi-center studies. In the method, PET score = 1 is the 95% prediction limit of AD. PET score and diagnostic accuracy for the discrimination of AD were evaluated in simulated images using the original ADNI dataset as reference.

    Results

    Positron emission tomography score was slightly underestimated both in ZTE and Atlas group compared with reference CTAC (−0.0796 ± 0.0938 vs. −0.0784 ± 0.1724). The absolute error of PET score was lower in ZTE than Atlas group (0.098 ± 0.075 vs. 0.145 ± 0.122, p &amp;lt; 0.001). A higher correlation to the original PET score was observed in ZTE vs. Atlas group (R2: 0.982 vs. 0.961). The accuracy for the discrimination of AD patients from normal control was maintained in ZTE and Atlas compared to CTAC (ZTE vs. Atlas. vs. original; 82.5% vs. 82.1% vs. 83.2% (CI 81.8–84.5%), respectively).

    Conclusion

    For FDG-PET images on PET/MR, attenuation correction using ZTE-MRI had superior accuracy to an atlas-based method in classification for dementia. ZTE maintains the diagnostic accuracy for AD.

    DOI: 10.3389/fnins.2020.569706

    researchmap

  • Turbulent Kinetic Energy Is Different from Viscous Energy Loss

    Kotomi Iwata, Tetsuro Sekine, Izumi Tanaka, Takahiro Ando, Erika Orita

    RadioGraphics   2020.11

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1148/rg.2020200177

    researchmap

  • Multiparametric flow analysis using four-dimensional flow magnetic resonance imaging can detect cerebral hemodynamic impairment in patients with internal carotid artery stenosis

    Takahiro Ando, Tetsuro Sekine, Yasuo Murai, Erika Orita, Ryo Takagi, Yasuo Amano, Kotomi Iwata, Masatoki Nakaza, Masashi Ogawa, Makoto Obara, Shin-ichiro Kumita

    Neuroradiology   62 ( 11 )   1421 - 1431   2020.6

     More details

    Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    DOI: 10.1007/s00234-020-02464-2

    researchmap

    Other Link: https://link.springer.com/article/10.1007/s00234-020-02464-2/fulltext.html

  • Prevalence of atrial FDG uptake and association with atrial arrhythmias in patients with cardiac sarcoidosis. Reviewed International journal

    Kenji Yodogawa, Yoshimitsu Fukushima, Takahiro Ando, Yu-Ki Iwasaki, Kazuyoshi Akiyama, Shin-Ichiro Kumita, Arata Azuma, Yoshihiko Seino, Wataru Shimizu

    International journal of cardiology   2020.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND: There is increasing evidence that a proportion of patients with cardiac sarcoidosis (CS) have atrial arrhythmias (AA). Although 18F-fluorodeoxy-glucose (FDG) uptake in the ventricle on positron emission tomography/computed tomography (PET/CT) is well studied, FDG uptake in the atrium has not been elucidated in detail. OBJECTIVES: To evaluate FDG uptake in the atrium and its relationship with AA in patients with CS. METHODS: We retrospectively investigated 62 CS patients. All patients underwent echocardiography and PET/CT. Serum angiotensin converting enzyme (ACE) and soluble IL-2 receptor (sIL-2R) levels, plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) concentrations were also evaluated. ECG, Holter monitoring and device interrogations were used to detect AA. RESULTS: Of the studied population, 25 patients (40.3%) had AA, of which 2 patients had atrial tachycardia (AT) and 23 patients had atrial fibrillation (AF). Eighteen patients with AA had atrial FDG uptake on PET/CT, whereas 14 patients without AA had atrial FDG uptake (72.0% vs 37.8%, P = 0.017). Multivariate analysis revealed a significant association between AA and age (odds ratio [OR]: 1.15; 95% confidence interval [CI]: 1.01-1.31, P = 0.040), atrial FDG uptake (odds ratio [OR]: 7.23; 95% confidence interval [CI]: 1.91-27.36, P = 0.004), and left atrial diameter (OR: 1.08; 95% CI: 1.01-1.16, P = 0.027). Meanwhile, gender, serum ACE and BNP levels, and left ventricular ejection fraction were not associated with AA. CONCLUSIONS: Atrial FDG uptake was common in patients with CS and strongly associated with AA.

    DOI: 10.1016/j.ijcard.2020.04.041

    PubMed

    researchmap

  • 4D Flow MRIを用いた片側内頸動脈狭窄症患者を対象とした血流multiparametric flow解析

    安藤 嵩浩, 関根 鉄朗, 村井 保夫, 織田 絵里香, 高木 亮, 天野 康雄, 小原 真, 岩田 琴美, 仲座 方辰, 汲田 伸一郎

    日本磁気共鳴医学会雑誌   40 ( 1 )   36 - 38   2020.2

  • 浅側頭動脈から中大脳動脈へのバイパス手術前後の脳血流についての4D Flow MRI分析(4D Flow MRI Analysis of Cerebral Blood Flow Before and After Superficial Temporal Artery to Middle Cerebral Artery Bypass Surgery)

    関根 鉄朗, 織田 絵里香, 村井 保夫, 高木 亮, 安藤 嵩浩, 岩田 琴美, 小川 匡史, 小原 真, 汲田 伸一郎

    日本医学放射線学会秋季臨床大会抄録集   55回   S488 - S489   2019.9

     More details

    Language:English   Publisher:(公社)日本医学放射線学会  

    researchmap

  • Four-Dimensional Flow MRI Analysis of Cerebral Blood Flow Before and After High-Flow Extracranial–Intracranial Bypass Surgery With Internal Carotid Artery Ligation

    Erika Orita, Yasuo Murai, Tetsuro Sekine, Ryo Takagi, Yasuo Amano, Takahiro Ando, Kotomi Iwata, Makoto Obara, Shinichiro Kumita

    Neurosurgery   85 ( 1 )   58 - 64   2018.5

     More details

    Publishing type:Research paper (scientific journal)   Publisher:Ovid Technologies (Wolters Kluwer Health)  

    Abstract

    BACKGROUND

    The hemodynamic changes that occur after high-flow (extracranial–intracranial) EC-IC bypass surgery with internal carotid artery (ICA) ligation are not well known.

    OBJECTIVE

    To assess blood flow changes after high-flow EC-IC bypass with ICA ligation by time-resolved 3-dimensional phase-contrast (4D Flow) magnetic resonance imaging (MRI).

    METHODS

    We enrolled 11 patients who underwent high-flow EC-IC bypass. 4D Flow MRI was performed before and after surgery to quantify the blood flow volume (BFV) of the ipsilateral ICA (BFViICA), bypass artery (BFVbypass), contralateral ICA (BFVcICA), and basilar artery (BFVBA). Subsequently, we calculated the total BFV (BFVtotal = BFViICA + BFVcICA + BFVBA [before surgery], BFVcICA + BFVBA + BFVbypass [after surgery]). The BFV changes after bypass was statistically analyzed.

    RESULTS

    BFVbypass was slightly lower than BFViICA, but the difference was not statistically significant (3.84 ± 0.94 vs 4.42 ± 1.38 mL/s). The BFVcICA and BFVBA significantly increased after bypass surgery (BFVcICA 5.89 ± 1.44 vs 7.22 ± 1.37 mL/s [P = .0018], BFVBA 3.06 ± 0.41 vs 4.12 ± 0.38 mL/s [P &lt; .001]). The BFVtotal significantly increased after surgery (13.37 ± 2.58 vs 15.18 ± 1.77 mL/s [P = .015]). There was no evidence of hyperperfusion syndrome in any cases.

    CONCLUSION

    After high-flow EC-IC bypass with permanent ICA ligation, the bypass artery could partially compensate for the loss of BFV of the sacrificed ICA. The increased flow of the contralateral ICA and BA supply collateral blood flow. Clinically irrelevant hyperperfusion was observed.

    DOI: 10.1093/neuros/nyy192

    researchmap

▼display all

Misc.

  • 心臓サルコイドーシス例における心筋病変炎症活性の定量解析を用いたFDG-PET/CTの予後予測能

    安藤 嵩浩, 福嶋 善光, 汲田 伸一郎, 橋本 英伸, 杉原 康朗

    核医学   54 ( Suppl. )   S174 - S174   2017.9

     More details

    Language:Japanese   Publisher:(一社)日本核医学会  

    researchmap

Awards

  • 学術奨励賞

    2019.9   日本磁気共鳴学会  

     More details