掲載種別：研究論文（学術雑誌）   出版者・発行元：Elsevier BV  

DOI： 10.1016/j.ctro.2022.09.005

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記述言語：日本語   出版者・発行元：(公社)日本医学放射線学会  

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記述言語：日本語   出版者・発行元：(公社)日本医学放射線学会  

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記述言語：日本語   出版者・発行元：(一社)日本皮膚悪性腫瘍学会  

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記述言語：日本語   出版者・発行元：金原出版(株)  

＜文献概要＞皮膚悪性腫瘍と他臓器悪性腫瘍の合併はときにみられるが,ともに進行癌の場合は治療に難渋する。症例は72歳,女性。幼少期に受傷した右上肢の熱傷瘢痕から有棘細胞癌が出現し,また所属外リンパ節転移を有するStage IVの右乳癌も重複していた。右上肢からの出血量が多く輸血を要したため,有棘細胞癌の手術を優先した。1cmマージンで切除し,植皮で再建したが,同部位に局所再発がみられ再切除した。乳癌は内分泌療法を施行し,腫瘍・リンパ節の著明な縮小がみられたため,乳房切除,右腋窩リンパ節郭清術を施行した。現在,有棘細胞癌,乳癌ともに完全奏効の状態である。重複癌をきたした場合,予後規定因子やQOL(生活の質)などを踏まえたうえで治療の優先順位を決定することが重要となる。

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記述言語：日本語   出版者・発行元：(一社)日本皮膚悪性腫瘍学会  

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記述言語：日本語   掲載種別：研究論文（学術雑誌）   出版者・発行元：金原出版(株)  

＜文献概要＞79歳,男性。2017年1月に当科を受診。臨床的にはパンツ型紅斑を呈していた。組織学的に癌性リンパ管症を伴う外陰部乳房外Paget病と診断した。多発骨転移,多発リンパ節転移があったためStage IVと診断した。放射線療法とドセタキセル投与にて紅斑局面はほぼ消失した。統合失調症の既往があり,外来での放射線療法,化学療法の施行が困難だったため,上記治療は基本的に入院で施行した。当初は一般病棟入院としたが,徘徊・不眠症状が強く入院継続困難となり,精神科病棟に転棟し精神科管理の下で,幻聴などの陽性症状なく安定した精神状態を維持できた。統合失調症の合併症のある癌患者では,癌治療のための入院中にせん妄の問題を生じることが多い。しかし細かな精神科回診などを行えば,ほとんどの例で入院継続が可能である。

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：SPRINGER JAPAN KK  

© 2018, Japan Society of Clinical Oncology. Background: To determine the current practice of stereotactic irradiation (STI) for brain metastases in Japan by a questionnaire survey. Methods: A questionnaire was distributed to 313 institutions performing STI with one of the following machines: Gamma Knife (GK), CyberKnife (CK), Novalis (Nov), or other linear accelerator (LINAC)-based systems (OLS). The participation was voluntary. Results: There were 163 responding institutions. The total number of STI treatments between April 2013 and March 2014 was 10,684. Stereotactic radiosurgery (SRS) and fractionated stereotactic radiotherapy (SRT) were performed in 8624 (80.7%) and 2060 (19.3%) cases, respectively. Whole-brain radiation therapy (WBRT) was performed for a total of 3515 cases. For a case model of a 1.5-cm solitary brain metastasis in a non-eloquent area, the most common GTV-PTV margin was 2 mm (22 of 114 institutions), and an institutional standard fraction was 1 (75 of 114 institutions). The doses for the model case also varied from 13.0 to 26.0 Gy (Median 20 Gy) when converted to SRS (α/β = 10). A prescription point was at the PTV margin the most. The median dose constraints which were converted to SRS (α/β = 3) to organs at risk were 12.2, 12.7, and 13.7 Gy for optic nerves, cavernous sinus, and brainstem, respectively. Conclusions: STI for brain metastases in current practice varied significantly among institutions. These different strategies relied mostly on the type of treatment machine used. It is thus necessary to establish a common guideline to express dose prescriptions and plan qualities for different STI machines.

DOI： 10.1007/s10147-018-1313-4

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記述言語：日本語   出版者・発行元：(一社)日本頭頸部癌学会  

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DOI： 10.1200/JCO.2018.36.6_suppl.142

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DOI： 10.3171/2014.10.FOCUS14651

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：AMER ASSOC NEUROLOGICAL SURGEONS  

Object. The objective of the present study was to perform a prospective evaluation of the potential efficacy and safety of intraoperative photodynamic therapy (PDT) using talaporfin sodium and irradiation using a 664-nm semiconductor laser in patients with primary malignant parenchymal brain tumors.
Methods. In 27 patients with suspected newly diagnosed or recurrent primary malignant parenchymal brain tumors, a single intravenous injection of talaporfin sodium (40 mg/m(2)) was administered 1 day before resection of the neoplasm. The next day after completion of the tumor removal, the residual lesion and/or resection cavity were irradiated using a 664-nm semiconductor laser with a radiation power density of 150 mW/cm(2) and a radiation energy density of 27 J/cm(2). The procedure was performed 22-27 hours after drug administration. The study cohort included 22 patients with a histopathologically confirmed diagnosis of primary malignant parenchymal brain tumor. Thirteen of these neoplasms (59.1%) were newly diagnosed glioblastomas multiforme (GBM).
Results. Among all 22 patients included in the study cohort, the 12-month overall survival (OS), 6-month progression-free survival (PFS), and 6-month local PFS rates after surgery and PDT were 95.5%, 91%, and 91%, respectively. Among patients with newly diagnosed GBMs, all these parameters were 100%. Side effects on the skin, which could be attributable to the administration of talaporfin sodium, were noted in 7.4% of patients and included rash (2 cases), blister (1 case), and erythema (1 case). Skin photosensitivity test results were relatively mild and fully disappeared within 15 days after administration of photosensitizer in all patients.
Conclusions. Intraoperative PDT using talaporfin sodium and a semiconductor laser may be considered as a potentially effective and sufficiently safe option for adjuvant management of primary malignant parenchymal brain tumors. The inclusion of intraoperative PDT in a combined treatment strategy may have a positive impact on OS and local tumor control, particularly in patients with newly diagnosed GBMs. Clinical trial registration no.: JMA-IIA00026 (https://dbcentre3.jmacct.med.or.jp/jmactr/App/JMACTRS06/JMACTRS06.aspx?seqno=862).

DOI： 10.3171/2013.7.JNS13415

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：JAPAN NEUROSURGICAL SOC  

The importance of surgical resection for patients with supratentorial low-grade glioma (LGG) remains controversial. This retrospective study of patients (n = 153) treated between 2000 to 2010 at a single institution assessed whether increasing the extent of resection (EOR) was associated with improved progression-free survival (PFS) and overall survival (OS). Histological subtypes of World Health Organization grade II tumors were as follows: diffuse astrocytoma in 49 patients (32.0%), oligoastrocytoma in 45 patients (29.4%), and oligodendroglioma in 59 patients (38.6%). Median pre- and postoperative tumor volumes and median EOR were 29.0 cm(3) (range 0.7-162 cm(3)) and 1.7 cm(3) (range 0-135.7 cm(3)) and 95%, respectively. Five- and 10-year OS for all LGG patients were 95.1% and 85.4%, respectively. Eight-year OS for diffuse astrocytoma, oligoastrocytoma, and oligodendroglioma were 70.7%, 91.2%, and 98.3%, respectively. Five-year PFS for diffuse astrocytoma, oligoastrocytoma, and oligodendroglioma were 42.6%, 71.3%, and 62.7%, respectively. Patients were divided into two groups by EOR >= 90% and <90%, and OS and PFS were analyzed. Both OS and PFS were significantly longer in patients with >= 90% EOR. Increased EOR resulted in better PFS for diffuse astrocytoma but not for oligodendroglioma. Multivariate analysis identified age and EOR as parameters significantly associated with OS. The only parameter associated with PFS was EOR. Based on these findings, we established updated therapeutic strategies for LGG. If surgery resulted in EOR <90%, patients with astrocytoma will require second-look surgery, whereas patients with oligodendroglioma or oligoastrocytoma, which are sensitive to chemotherapy, will be treated with chemotherapy.

DOI： 10.2176/nmc.53.447

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：OXFORD UNIV PRESS  

oDropped head syndrome' (DHS) is characterized by severe weakness of the muscles of the back of the neck, resulting in chin-on-chest deformity. Dropped head syndrome induced by radiotherapy is very rare. We report a case of DHS following chemoradiotherapy with a total of 64.8 Gy in 36 fractions for nasopharyngeal carcinoma.

DOI： 10.1093/jjco/hys135

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：ELSEVIER SCIENCE INC  

Purpose: To evaluate and compare the efficacy of medium-dose-rate (MDR) and low-dose-rate (LDR) intracavitary brachytherapy (ICBT) for uterine cervical cancer.
Methods and Materials: We evaluated 419 patients with squamous cell carcinoma of the cervix who were treated by radical radiotherapy with curative intent at Tokyo Women's Medical University from 1969 to 1999. LDR was used from 1969 to 1986, and MDR has been used since July 1987. When compared with LDR, fraction dose was decreased and fraction size was increased (1 or 2 fractions) for MDR to make the total dose of MDR equal to that of LDR. In general, the patients received a total dose of 60 to 70 Gy at Point A with external beam radiotherapy combined with brachytherapy according to the International Federation of Gynecology and Obstetrics stage. In the LDR group, 32 patients had Stage I disease, 81 had Stage II, 182 had Stage III, and 29 had Stage IVA; in the MDR group, 9 patients had Stage I disease, 19 had Stage II, 55 had Stage III, and 12 had Stage IVA.
Results: The 5-year overall survival rates for Stages I, II, III, and IVA in the LDR group were 78%, 72%, 55%, and 34%, respectively. In the MDR group, the 5-year overall survival rates were 100%, 68%, 52%, and 42%, respectively. No significant statistical differences were seen between the two groups. The actuarial rates of late complications Grade 2 or greater at 5 years for the rectum, bladder, and small intestine in the LDR group were 11.1%, 5.8%, and 2.0%, respectively. The rates for the MDR group were 11.7%, 4.2%, and 2.6%, respectively, all of which were without statistical differences.
Conclusion: These data suggest that MDR ICBT is effective, useful, and equally as good as LDR ICBT in daytime (about 5 hours) treatments of patients with cervical cancer. (C) 2012 Elsevier Inc.

DOI： 10.1016/j.ijrobp.2011.10.066

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記述言語：日本語   掲載種別：研究論文（学術雑誌）   出版者・発行元：13  

Malignant peritoneal mesothelioma is extremely rare, and its prognosis is poor. The median survival period is said to be approximately one year after diagnosis. We report a case of recurrent malignant peritoneal mesothelioma treated with concurrent chemoradiotherapy (CCRT). The patient has been alive for six years without recurrence. This report seems to be the first that indicates CCRT to be useful for peritoneal mesothelioma. The patient was a 21-year-old woman who underwent emergency surgery of the in acute abdomen at another hospital. The resected tumor was 18 cm in size and pathological examination revealed that it was a malignant mesothelioma of the epithelioid type. CAP therapy (cyclophosphamide+adriamycine+cisplatin)+CPT-11 administration was given only one course, and the patient was then transferred to our hospital. She underwent resection of the residual disease and six courses of TC therapy (paclitaxel+carboplatin) as adjuvant chemotherapy. Twelve months after chemotherapy, pelvic recurrence occurred. We attempted surgery but only biopsy could be performed because of a pelvic wall invasion. The patient underwent CCRT with weekly cisplatin. The tumor was reduced by irradiation of 50.4 Gy and disappeared after 6 months. No recurrence has been found six years since the last treatment. CCRT might be effective against malignant peritoneal mesothelioma of the epithelioid type.

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：SPRINGER  

Trilateral retinoblastoma (TRb) is an intracranial neurogenic tumor associated with unilateral or bilateral retinoblastoma and has very poor prognosis. Patients typically die from leptomeningeal tumor dissemination.
A 3-year-old girl who had been diagnosed with TRb had a disseminated relapse after a tumorectomy, cerebrospinal irradiation, and conventional chemotherapy. The disseminated tumor disappeared after the first autologous peripheral blood stem cell transplantation (PBSCT) with high-dose melphalan and thiotepa. During the second complete remission, a second autologous PBSCT with high-dose busulfan and melphalan was performed. Seven months after the first PBSCT, the second relapse occurred, and we subsequently performed an allogeneic PBSCT with myeloablative chemotherapy consisting of melphalan, thiotepa, and cyclophosphamide. The patient showed clinical improvement after the allogeneic PBSCT.
Although high-dose chemotherapies have a curative effect for some patients with TRb, the prognoses of disseminated tumors are still poor. Further examination of the high-dose chemotherapy is necessary for the time, the conditioning drugs, and the hematopoietic stem cell sources.

DOI： 10.1007/s00381-011-1419-8

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：OXFORD UNIV PRESS  

We conducted a prospective study to assess the anxiety and salivary Chromogranin A (CgA), which is considered to be a biomarker of the stress response, in outpatients receiving breast conserving surgery followed by radiation therapy (RT) to the whole breast. Fifty consecutive patients who received whole-breast RT were enrolled in this study. The anxiety levels were measured by the State-Trait Anxiety Inventory (STAI) at the beginning of RT (baseline), 30 Gy, completion of RT, and 1 and 3 months after RT. Salivary CgA levels were also measured at the same time. The mean state anxiety score for all patients was 46.16 with a standard error (SE) of 1.57 at the beginning of RT (baseline) which continued to decline during and after RT. It reached its lowest score with 36.34 +/- 1.56 at 3 months after RT (p < 0.0001). The mean trait anxiety score for all patients was 43.10 +/- 1.54 at baseline and remained constant during RT but began to decline after completion of RT and reached a low level at 3 months after RT (p = 0.0021). The mean salivary CgA concentration for all patients demonstrated no consistent trends over time, but at 30 Gy the concentration showed a significant decreasing pattern (p = 0.0473). Salivary CgA concentrations and state anxiety and trait anxiety scores at all time points showed no correlation. The mean anxiety scores measured by STAI showed no positive correlation with salivary CgA concentration for breast cancer patients undergoing radiation therapy following breast conserving surgery.

DOI： 10.1269/jrr.10160

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：LIPPINCOTT WILLIAMS & WILKINS  

We performed double high-dose chemotherapy followed by peripheral blood stem cell transplantation (PBSCT) in 3 children with medulloblastoma and primary leptomeningial dissemination, including spinal metastasis. After resection of the main tumor mass, 30.6 Gy whole craniospinal radiation therapy and 4 or 5 courses of conventional chemotherapy with vincristine (1.5 mg/m(2)), carboplatin (560 mg/m(2)), ifosfamide (9000 mg/m(2)), and etoposide (500 mg/m(2)), and 2 courses of high-dose thiotepa (680 mg/m(2)) and melphalan (240 mg/m(2)) therapy with PBSCT were administered. Two patients with low erythroblastic leukemia viral oncogene homolog 2 (ERBB2) gene expression achieved long-term survival (41 mo and 40 mo) but the patient with high ERBB2 expression relapsed 9 months after the second PBSCT.

DOI： 10.1097/MPH.0b013e3181c46b92

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：INT INST ANTICANCER RESEARCH  

Background: The aim of this study was to evaluate the impact of dysadherin and E-cadherin expression on the clinical outcomes, including the treatment outcomes and recurrence pattern, in patients with head and neck cancer. Patients and Methods: Tumor specimens were obtained from 48 head and neck cancer patients who were treated by radiation therapy and the specimens were immunohistochemically stained for dysadherin and E-cadherin. The expressions were graded according to the percentage area occupied by cancer cells showing positive staining for E-cadherin and dysadherin as follows: grade 0, less than 10%; grade 1, 10-50%; grade 2, more than 50%. The correlations between the expression of E-cadherin and dysadherin and the clinical outcomes, including the treatment outcomes and recurrence pattern, were analyzed. Results: The complete response (CR) rate in the patients with a dysadherin expression grade of 0 or 1 was 70% and that in the patients with dysadherin expression grade of 2 was 38%; the difference was significant (p<0.05). Regarding the pattern of recurrence, the expression grade of dysadherin or E-cadherin alone was not correlated with the recurrence pattern; however, patients with a difference in the expression grade between dysadherin and E-cadherin (Dys-Ecad value) of 1 or 2 showed a significantly higher rate of lymph node and/or distant metastasis (55%) as compared with those with a Dys-Ecad value of <1 (22%) (p<0.05). Conclusion: Dysadherin and E-cadherin expression might serve as useful prognostic factors in patients with head and neck cancer treated by definitive radiation therapy.

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：ELSEVIER SCIENCE INC  

Purpose: The aims of this study were twofold: (1) to examine the effects of dual inhibition of 2 members of the HER family, the epidermoid growth factor receptor (EGFR) and HER2/neu, by gefitinib (ZD1839) and trastuzumab on radiosensitivity; and (2) to explore the molecular mechanism of radiosensitization especially focusing on the survival signal transduction pathways by using A431 human vulvar squamous carcinoma cells expressing EGFR and HER2/neu.
Methods and Materials: The effects of inhibitors on the radiation-induced activation of EGFR and/or HER2/neu, and the intracellular proteins that are involved in their downstream signaling, were quantified by the Western blot. Radiosensitizing effects by the blockage of EGFR and/or HER2/neu were determined by a clonogenic assay.
Results: Radiation-induced activation of the EGFR and HER2/neu was inhibited with ZD1839 and/or trastuzumab. ZD1839 also inhibited the radiation-induced phosphorylation of HER2/neu. Radiation in combination with the HER family inhibitors inhibited the activation of Akt and MEK1/2, the downstream survival signaling of the HER family. ZD1839 enhanced radiosensitivity with a dose-modifying factor (DMF) (SF3) of 1.45 and trastuzumab did so with a DMF (SF3) of 1.11. Simultaneous blockade of EGFR and HER2/neu induced a synergistic radiosensitizing effect with a DMF (SF3) of 2.29.
Conclusions: The present data suggest that a dual EGFR and HER2/neu targeting may have potential for radiosensitization in tumors in which both of these pathways are active. (c) 2006 Elsevier Inc.

DOI： 10.1016/j.ijrobp.2006.05.036

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：7  

Purpose: Radiotherapy is considered to be associated with psychological distress. We assessed the mental status, anxiety, and the factors associated with these in cancer patients about to receive radiotherapy. Materials and Methods: Hospitalized patients about to receive radiotherapy participated. Psychological status was assessed by a psychiatrist, based on interview about the type of anxiety related to cancer or radiotherapy as well as self-rating questionnaires. Results: Eligible data were collected from 94 patients. The incidence of mental disorders was 20%. The total mood disturbance scores were significantly higher in patients with poor performance status. The most common type of anxiety regarding radiotherapy was acute adverse effect, and the predictors were palliative treatment and living alone. Conclusion: Mental disorders, mood disturbance, and anxiety in patients cannot be neglected in radiation oncology practice. Especially careful attention should be paid to patients with these predictive factors.

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：OXFORD UNIV PRESS  

Objective: The aim of this study is to establish Japanese national practice patterns for uterine cervical cancer patients who received radiotherapy without surgery.
Methods: The Japanese Patterns of Care Study (JPCS) conducted a national survey of 73 institutions using two-stage cluster sampling, and collected specific information on 591 patients with uterine cervical cancer treated by radiotherapy without planned surgery between 1995 and 1997.
Results: The median age of the patients was 70 years. Karnofsky performance status (KPS) was >= 90 for 37%. Most patients (95%) had histology of squamous cell carcinoma. Ten percent were stage I, 29% stage II, 48% stage III and 13% stage IVA. Photon beams of 10-14 MV were the most used for external beam radiotherapy (EBRT). The beam energy utilized varied significantly by institution strata. Midline block was used in similar to 70% of institutions. Intracavitary brachytherapy (ICBT) was performed in 77%. Institution strata correlated significantly with the ICBT application. The majority of patients (89%) were treated with high-close-rate (HDR) ICBT. The median single point A dose of HDR-ICBT was 600 cGy. The median summated point A dose from EBRT and HDR-ICBT was 5800 cGy (range: 1196-8600). The median overall treatment time including ICBT was 49 days. Twenty-four percent of the patients received chemotherapy. Concurrent chemoradiation was performed in 5%.
Conclusions: The JPCS established the Japanese national practice patterns of care for uterine cervical cancer patients treated with radiotherapy without planned surgery between 1995 and 1997. This survey demonstrated that the institutional strata significantly affected several practice patterns.

DOI： 10.1093/jjcolhyi047

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：OXFORD UNIV PRESS  

Objective: To determine the average national practice of postoperative radiotherapy for uterine cervical cancer in Japan.
Methods: The Japanese Patterns of Care Study (PCS) reviewed the process of care employed for 455 uterine cervical cancer patients who were treated with surgery followed by postoperative radiotherapy (RT) during 1995-1997. Cases with missing data were excluded from calculations of percentage and significance for each of the surveyed items.
Results: According to FIGO stages, 198 patients (45%) were in stage 1, 52 patients (12%) were in stage IIA, 146 patients (33%) were in stage 1113 and 46 patients (10%) were in stage III/IVA. The most common surgical procedure among the patients was radical hysterectomy (73%). Three hundred and seventy patients (82%) were treated with external beam FIT (ERT) alone, and 74 patients (17%) were treated with a combination of ERT and intracavitary FIT (ICRT). A midline block was used for the pelvic field in 63 patients (14%). Only seven patients (2%) were treated with extended field ERT. Pelvic ERT was most often performed using AP-PA opposed fields for 431 patients (97%). A majority of the patients (312 patients, 70%) were treated with a total dose of 45.0-50.4 Gy for ERT. Chemotherapy (CT) was administered to 178 patients (40%), neoadjuvant preoperative CT was administered to 80 patients (22%) and concurrent CT with postoperative RT was administered to 29 patients (8%).
Conclusion: This PCS established the national practice average of postoperative RT for uterine cervical cancer. Follow-up studies need to be conducted to determine whether the observed differences in treatment processes affect outcomes.

DOI： 10.1093/jjco/hyh014

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：INT INST ANTICANCER RESEARCH  

Background: The aim of this study was to improve tumor control, the survival rate and organ preservation for locally advanced head and neck cancer by using induction chemotherapy followed by hyperfractionated radiotherapy and concurrent chemotherapy. Materials and Methods: Thirty-five patients with stage III-IVB head and neck cancer were treated with this protocol. Induction chemotherapy consisted of cisplatin and fluorouracil and concurrent chemotherapy consisted of carboplatin and doxifluridin. Radiotherapy was administered twice a day until a dose of 72 Gy was reached. Results: Twenty-two (63%) and 13 patients (37%) achieved complete responses and partial responses, respectively. In terms of non-hematological toxicities, grade 3 mucositis was observed in 49 % of the patients. The overall 5-year survival was 53.5 % and the progression-free survival was 40.6 %. Conclusion: Response to induction chemotherapy was useful as a predictive factor for ultimate outcome and organ conservation. More intensive regimen or other combination chemotherapy is needed to improve treatment outcome with hyperfractionated radiotherapy.

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：INT INST ANTICANCER RESEARCH  

Background: This study was designed to evaluate the concomitant use of docetaxel and carboplatin for radiosensitization in head and neck cancer. Materials and Methods: One dose of docetaxel at 10 mg/m(2) and five doses of carboplatin at AUC of 0.4 per week were administered to patients during the first two weeks of radiotherapy. Sixteen patients were treated with this regimen. Radiotherapy was given to a total dose of 64.8 to 82.0 Gy. Altered fractionation radiotherapy was performed in 12 patients with untreated advanced tumors. Results: The complete response (CR) rate was 81%, with a partial response (PR) rate of 19%. Toxicities included grade 3 mucositis in 69% of patients and grade 2 dermatitis in 56% of patients. Conclusion:, This schedule of docetaxel and carboplatin combined with radiotherapy may become a useful approach for the management of head and neck cancer with proper management of mucositis.

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：INT INST ANTICANCER RESEARCH  

We investigated the signal transduction pathway to low-dose radiation-induced apoptosis in vitro in the human peripheral primitive neuroectodermal tumor (pPNET) cell line with wild-type p53 established in our laboratory. Apoptosis was induced by 2Gy irradiation in an almost p53-dependent manner in this model except for a deficiency of the cleavage of caspase-9. It was detected 3 hours after irradiation by fragmentation assay. The expressions of p53, p21(WAF-1) and Bax increased, in contrast to the gradually decreasing expression of Bcl-2, as observed by immunoblotting. Following this, cleavages of caspase-3 and PARP reached peak levels. There were no detectable increases in ERK expression and caspase-9 cleavage. In respect of the probability of other pathways to apoptosis, this cell line will provide a useful model both for investigating low-dose radiation-induced signal transduction pathway and for analyzing the biological characteristics of pPNET

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：3  

Background: Docetaxel has shown remarkable radiosensitizing properties in vitro. In this study we investigated whether the addition of docetaxel to radiotherapy enhanced tumor response in patients with advanced or recurrent breast cancer. Methods: A total of 35 patients were enrolled in this study. Docetaxel was administered concurrently during radiotherapy. Radiation doses were 54 to 69 Gy (median 60 Gy). In those enrolled through January 2000, docetaxel 40 mg/m 2 was administered biweekly (once every two weeks), with subsequent dose adjustments based on tolerance and bone marrow and liver function. Beginning in February 2000, a weekly docetaxel schedule was used instead. This new regimen was based on data suggesting reduced myelosuppression with this regimen. The weekly dose rate was 20 mg/m 2, with dose reductions for impaired organ function. Results: All patients were evaluated for toxicity and response and a total of 40 irradiated sites were evaluated for local response. The overall response rate of irradiated sites was 95% and the CR rate was 68%. CR and PR were achieved in 40%, 37% of patients, respectively. Acute toxicities were tolerated by most patients: 17% had Grade 3-4 neutropenia, 6% had Grade 3-4 radiation dermatitis, and 3% had Grade 3-4 pneumonitis. Conclusion: The combination of docetaxel with radiotherapy is an active and safe regimen in patients with inoperable advanced or recurrent breast cancer. We determined the recommended dose of docetaxel with concomitant radiotherpy to be 20 mg/m 2 weekly for a Phase II study. Further study is necessary to assess the impact of this treatment on long-term outcome.

DOI： 10.1007/BF02966728

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：OXFORD UNIV PRESS  

Primary malignant lymphoma of the uterine body is extremely rare. There are few reports concerning magnetic resonance images (MR) of uterine body lymphoma although there are several reports concerning uterine cervical lymphoma. The MR images of a 66-year-old woman with primary malignant lymphoma of the uterine body showed that the myometrium was diffusely involved, exhibiting an almost homogeneous character, and the normal zonal anatomy of the uterine cervix was preserved, with the endometrium being partly recognized near the center of the tumor. We report suggestive findings on MR images of primary malignant lymphoma of the uterine body.

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：ELSEVIER SCI IRELAND LTD  

The differences between two rat yolk sac tumor cell lines, which are of the same origin but differ in their response to irradiation, in thermal sensitivity and development of thermotolerance were investigated. A radiosensitive cell line NMT-1 is consistently less heat sensitive than the radioresistant cell line NMT-1R. The thermotolerances in NMT-1 and in NMT-1R preheated at 43 degrees C for 30 min, respectively, reached peaks at 6 h and at 12 h, but did not completely disappear at 48 h. Thermotolerance with a good correlation between both cell Lines with HSP70 accumulation was observed in a different time course after a primary heating. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

A case of embryonal rhabdomyosarcoma (RMS) arising from adult lower proximal extremity is described. Rhabdomyosarcoma (RMS) is most common among children, but adult embryonal RMS is rare. The patient was a 44-year-old man with a large tumor of the left extremity invading to the pelvis. The histological diagnosis was embryonal RMS. Radiation therapy was delivered a total dose of 50 Gy to the tumor. Although adult RMS, usually pleomorphic type, is considered to be radioresistant, the tumor showed marked response to radiotherapy and local control was achieved easily in this case.

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

Relationships between p53 protein expression and radiation-induced apoptosis in five human tumors transplanted to nude mice were studied immunohistochemically. They were irradiated with 200 kV X-rays. Six hours after 2, 5, 10, or 20 Gy irradiation, tumors were excised and fixed. Tumors were also examined 1-48 hours after 10 Gy. Immunohistochemical studies were performed for analysis of p53 protein expression. TUNEL and electron microscopic studies were performed to identify apoptosis. In non-irradiated control groups, the incidence of apoptosis was very low in all of the five tumors. Most tumor cells of the ependymoblastoma were p53 protein negative, but the other four tumors were p53 positive. Following irradiation, most tumor cells of the ependymoblastoma became p53 positive, and the incidence of apoptosis increased. However, we could not find significant changes in the percentage of p53 positive cells in the other tumors, and radiation-induced apoptosis in them was low or negligible. These results suggest that radiation-induced apoptosis in a radiosensitive human tumor is related to wild-type p53 protein expression. In contrast, the p53 protein expression of the other four human tumors should be mutant type, and it does not lead to radiation-induced apoptosis.

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記述言語：日本語   掲載種別：研究論文（学術雑誌）   出版者・発行元：The Kitakanto Medical Society  

症例は血性帯下, 血便を主訴に来院した49歳の女性である.子宮頸癌IV a期と診断され, 放射線治療が行われた.子宮頸部の腫瘍は照射により消失したが, 治療終了から3週後に全身に多発性の皮下転移が認められた.組織学的には線維性皮下組織に浸潤し多数の核分裂像をもった腫瘍細胞からなる扁平上皮癌であった.子宮頸癌の皮下転移は比較的まれで, 現在までに報告された症例は検索した範囲では31例をみるにすぎない.症例を供覧し文献的考察を加え報告する.

DOI： 10.2974/kmj1951.46.67

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：RADIOLOGICAL SOC NORTH AMER  

PURPOSE: To evaluate the usefulness of radiation therapy for elderly patients with squamous cell carcinoma of the uterine cervix.
MATERIALS AND METHODS: Two hundred ninety-three patients with squamous cell carcinoma of the uterine cervix underwent external pelvic irradiation and three sessions of low-dose-rate intracavitary irradiation. One hundred twenty-six patients were aged 70 years or older (elderly group), and 167 patients were aged 69 years or younger (younger group). Survival rates, pattern of failure, local control rates, and complications for the two groups were compared.
RESULTS: The 5-year, cause-specific survival rates for the elderly group with stage I, II, III, or IV disease were 100%, 81%, 73%, and 54%, respectively. Corresponding rates for the younger group were 100%, 92%, 74%, and 32%. Differences in survival curves, patterns of failure, recurrence rates, and incidences of radiation complications for the two groups were not statistically significant.
CONCLUSION: Age did not influence the effectiveness of radiation therapy for the elderly patients.

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記述言語：英語   出版者・発行元：(一社)日本癌治療学会  

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記述言語：日本語   出版者・発行元：医学図書出版(株)  

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記述言語：日本語   出版者・発行元：医学図書出版(株)  

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記述言語：日本語   出版者・発行元：(一社)日本頭頸部癌学会  

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記述言語：日本語   出版者・発行元：(一社)日本泌尿器科学会総会事務局  

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記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）   出版者・発行元：ELSEVIER SCIENCE INC  

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記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）   出版者・発行元：ELSEVIER SCIENCE INC  

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記述言語：日本語   出版者・発行元：東京女子医科大学  

原発性脳腫瘍は悪性であっても中枢神経系外に転移することはまれである。また、悪性では境界が不明瞭で、十分な全摘をするのは困難である。さらに、脳内には血液脳関門が存在するため、化学療法薬剤の病変へ到達が十分ではなく、体幹部病変よりも効果が劣るのが一般的である。これらのことから、体幹部悪性腫瘍と比べ、原発性悪性脳腫瘍の治療には、局所治療である放射線治療の役割は大きく、どのようなタイミングで、どのような範囲に、どの程度を、照射するのかが治療戦略の上で重要な位置を占める。しかし、原発性脳腫瘍の種類は多く、放射線治療が効きやすいものからあまり効かないものまで多数ある。本章では、放射線治療や化学療法の効果からみた原発性悪性脳腫瘍に対する治療戦略のアウトライン、原発性悪性脳腫瘍に対する放射線治療に対する有害事象とその特徴、原発性悪性脳腫瘍に対する放射線治療の進歩について説明した。放射線治療の進歩では、放射線治療の高精度化として、MRIやPET画像の応用法や実際の高精度放射線治療(SRS/SRT(定位手術的照射/定位放射線治療)、IMRT(強度変調放射線治療))を、新たに発見された分子マーカーと集学的治療の中での放射線治療の役割について、悪性神経膠腫などの摘出術が必要な疾患をもとに、治療感受性に関わる分子マーカーの結果に応じた新たな試験的治療をまとめた。

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その他リンク： http://hdl.handle.net/10470/30569

記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）   出版者・発行元：OXFORD UNIV PRESS INC  

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記述言語：日本語   出版者・発行元：東京女子医科大学  

東京女子医科大学は臨床に強い病院である。先端的診断・治療・手技の臨床導入に積極的であり、多くの日本初の医療を行なってきた実績がある。しかし薬事法改正によって未承認医療機器や適応外薬剤の臨床研究での使用が困難になり、また臨床医の日常臨床業務が煩雑なため、新規性の高い臨床研究を実施できなくなった。すなわち臨床研究に強い病院であるとは言えない状態である。。この課題を克服し臨床研究・治験に強い病院に進化するためには、研究者を徹底的にサポート(パワーサポート)するシステムが必要である。そこで我々は、2012年春に臨床研究支援センター(Intelligent CLinical Research and Innovation Center:iCLIC)を設立した。iCLICの3大機能として、入口出口戦略に基づいた研究計画作成支援、先端臨床ITシステムPOPSを核としたGCP準拠臨床研究支援、レギュラトリーサイエンスに基づいた産官学融合規制開発がある。東京女子医大の豊富な研究シーズと細胞シート、人工心臓、インテリジェント手術室等の実例にみられる出口突破力を十分に生かせる仕組みとし、5年後のGCP準拠の臨床研究年30件施行を目指す。

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その他リンク： http://hdl.handle.net/10470/30094

記述言語：日本語   出版者・発行元：東京女子医科大学  

日本の臨床研究は欧米から大きく立ち遅れているといわれて久しい。新たな発見や知見があっても日本で成熟させることができない理由は何であるのか。そこには臨床研究実施体制がシステム化されていないこと、そして臨床医の臨床研究に対する見識の乏しさが挙げられるだろう。また、ものづくり日本の実力が発揮されるべき治療機器分野では医療サイドと技術的シーズを持つ研究者・企業サイドとの連携が乏しいことも臨床研究・治験をさらに停滞させている。,東京女子医科大学には、我が国初の補助人工心臓や細胞シートなど探索型臨床研究、国産医療機器と薬物による我が国初の複合治療医師主導治験を行ってきた実績があり、治療機器の豊富なシーズ、ステントや人工臓器で実績のある日本唯一の医療機器評価系(東京女子医科大学・早稲田大学連携先端生命医科学研究教育施設TWIns内)、そして豊富な患者数(東京女子医科大学医療施設群として200万人/年)を有する臨床実績がある。臨床研究支援センター(Intelligent Clinical Research and Innovation Center: iCLIC)はこれらを有機的に連携・活用し、迅速でかつ質の高い臨床研究実施を強化する目的で設立された。,iCLICでは、入口戦略から出口戦略、市販後臨床評価までをシステム化し、イノベーションサイエンスからレギュラトリーサイエンスまでを包括した強固な研究基盤を作り上げることを目標とし、(1)他施設・企業とのマッチングプログラム、(2)アイディアのある研究者に対して具体的な研究提案まで行う事前相談プログラム、(3)研究プロダクツとしての論文作成・各種申請書作成支援プログラム、(4)知財管理プログラム、(5)教育・研修・広報プログラム作成に現在取り組んでいる。

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その他リンク： http://hdl.handle.net/10470/30087

記述言語：日本語   出版者・発行元：メディカルレビュー社  

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その他リンク： http://search.jamas.or.jp/link/ui/2013247521

記述言語：英語   掲載種別：速報，短報，研究ノート等（学術雑誌）  

DOI： 10.1016/j.ijrobp.2013.01.015

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記述言語：日本語   出版者・発行元：総合医学社  

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記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）   出版者・発行元：ELSEVIER SCIENCE INC  

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記述言語：日本語   出版者・発行元：篠原出版新社  

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記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）   出版者・発行元：ELSEVIER SCIENCE INC  

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記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）   出版者・発行元：ELSEVIER SCIENCE INC  

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記述言語：日本語   出版者・発行元：科学評論社  

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記述言語：日本語   出版者・発行元：社団法人 日本産科婦人科学会  

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DOI： 10.5981/jjhnc.34.530

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記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）   出版者・発行元：ELSEVIER SCIENCE INC  

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DOI： 10.5981/jjhnc.34.530

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記述言語：日本語   出版者・発行元：東京女子医科大学  

Utility of radiation therapy against carcinoma is recently on the increase in number in Japan. Radiotherapy is possible to preserve the organ with cancer and maintain the QOL (quality of life) and is one of the curative therapy for cancer. A wide use radiotherapy at the present time is external beam radiation. However external beam radiotherapy is not able to perfectly block the normal organ around the target of radiotherapy. In order to solve this problem, progress of computer technology in recent years is used, and extremely precision radiotherapy is developed. In extremely precise radiotherapy, there are 3D-comformal radiation therapy (3D-CRT), intensity modulated radiation therapy (IMRT), stereotactic radiation surgery (SRS), stereotactic radiation therapy (SRT) and particle therapy. On the other hand, with progress of molecular biology in recent years, the molecular target medicine which carries out the feeling of increase of the radiation sensitivity is developed and the gene analysis, single nucleotide polymorphism (SNP), is performed in order to determine the optimal radiation therapy for every patient (tailor maid radiotherapy). Thus, the present radiotherapy has been carrying out new development with progress of radiation physics or radiation biology.

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記述言語：日本語   出版者・発行元：東京女子医科大学  

Utility of radiation therapy against carcinoma is recently on the increase in number in Japan. Radiotherapy is possible to preserve the organ with cancer and maintain the QOL (quality of life) and is one of the curative therapy for cancer. A wide use radiotherapy at the present time is external beam radiation. However external beam radiotherapy is not able to perfectly block the normal organ around the target of radiotherapy. In order to solve this problem, progress of computer technology in recent years is used, and extremely precision radiotherapy is developed. In extremely precise radiot...

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記述言語：日本語  

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記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）   出版者・発行元：JOHN WILEY & SONS LTD  

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語  

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記述言語：日本語   出版者・発行元：篠原出版  

CiNii Books

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語  

J-GLOBAL

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記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）   出版者・発行元：RADIOLOGICAL SOC NORTH AMERICA  

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記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）   出版者・発行元：RADIOLOGICAL SOC NORTH AMERICA  

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語   出版者・発行元：現代医療社  

CiNii Books

J-GLOBAL

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語   出版者・発行元：現代医療社  

CiNii Books

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記述言語：英語  

CiNii Books

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語   出版者・発行元：一般社団法人日本消化器外科学会  

CiNii Books

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記述言語：日本語   出版者・発行元：一般社団法人日本消化器外科学会  

CiNii Books

J-GLOBAL

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語  

J-GLOBAL

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記述言語：英語   出版者・発行元：the Japan Radiation Research Society  

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その他リンク： https://projects.repo.nii.ac.jp/?action=repository_uri&item_id=236056

記述言語：日本語  

DOI： 10.5981/jjhnc1974.25.433

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記述言語：日本語  

DOI： 10.5981/jjhnc1974.25.433

CiNii Books

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記述言語：日本語   出版者・発行元：The Kitakanto Medical Society  

【目的】変異型p53細胞に対するカフェインの放射線増感効果を指標としてMTTアッセイ法の放射線感受性や放射線増感効果の評価法としての有用性を検討する.【材料・方法】ラット卵黄嚢腫瘍細胞由来でp53がん抑制遺伝子に変異を認めるNMT-IR細胞を用いて, カフェインによる放射線増感効果をMTTアッセイ法とコロニー形成法で比較検討した.【結果】MTTアッセイ法では, G2ブロックの解除が認められない濃度である0.5mMのカフェインによる放射線増感効果は認めなかったが, G2ブロックの解除が認められる濃度である2.0mMのカフェインでは放射線増感効果を認めた.コロニー形成法でも, 2.0mMのカフェインにのみ放射線増感効果が認められた.【結論】変異型p53を有するNMT-lRではカフェインによる放射線増感効果があることがコロニー法と同様にMTTアッセイ法でも立証しえたことから, MTTアッセイ法は放射線感受性や放射線増感効果の評価法として有用であると考えられた.

DOI： 10.2974/kmj.49.413

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語  

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語   出版者・発行元：日本肺癌学会  

CiNii Books

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記述言語：日本語   出版者・発行元：一般社団法人日本外科学会  

CiNii Books

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語   出版者・発行元：一般社団法人日本消化器外科学会  

CiNii Books

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語  

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記述言語：日本語   出版者・発行元：The Kitakanto Medical Society  

近年, 画像診断の進歩ならびに悪性腫瘍に対する治療成績の向上に伴い, 重複癌の頻度が急速に増加してきており, 重複癌に関して種々の組み合わせの報告が数多くされている.しかし, 現在までのところ子宮頸癌と腎細胞癌の重複癌に関する報告はあまりみられていない.今回, 子宮頸癌の放射線治療経過中に画像診断にて腎細胞癌が偶然発見され, 3年間にわたり経過を観察しえた症例を経験した.本症例は放射線治療が不完全な状態で終了したため, 子宮頸癌の局所再発により初回治療から3年1か月後に尿路障害にて死亡したが, 経過中に腎細胞癌の明らかな増大は認められなかった.剖検にて子宮頸癌と腎細胞癌の重複癌であることが確認された.

DOI： 10.2974/kmj.47.95

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記述言語：英語   出版者・発行元：The Kitakanto Medical Society  

The prognostic factors and the correlation between local control and total dose were investigated for the patients with invasive thymoma treated by a combination of radiation therapy and surgery or radiation therapy alone. Eighteen patients were retrospectively analyzed. Our treatment strategy was to give the target volume a total dose of at least 50 Gy for patients with microscopic residual and 60 Gy or more for macroscopic residual. The actuarial survival rates were 61 % at 5 years and 54 % at 10 years in all patients. All patients having a complete resection survived disease-free for more than 6 years while the survival rates of patients with macroscopic residual or unresected tumors were 38 % at 5 years and 25 % at 10 years (p<0.005). For macroscopic residual local recurrence rate within a radiation field was 0 % at a dose of 60 Gy or more, 67 % from 50 to 58 Gy and 100 % under 40 Gy, respectively. Invasive thymoma may be preferable to be treated at the dose of 50 Gy or more for microscopic residual and 60 Gy or more for macroscopic residual. Good prognosis may be expected in the patients undergoing complete resection and radiation therapy.

DOI： 10.2974/kmj.47.19

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記述言語：英語   出版者・発行元：the Japan Radiation Research Society  

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その他リンク： https://projects.repo.nii.ac.jp/?action=repository_uri&item_id=234972

記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）   出版者・発行元：PERGAMON-ELSEVIER SCIENCE LTD  

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記述言語：日本語  

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記述言語：日本語   出版者・発行元：The Kitakanto Medical Society  

症例は血性帯下, 血便を主訴に来院した49歳の女性である.子宮頸癌IV a期と診断され, 放射線治療が行われた.子宮頸部の腫瘍は照射により消失したが, 治療終了から3週後に全身に多発性の皮下転移が認められた.組織学的には線維性皮下組織に浸潤し多数の核分裂像をもった腫瘍細胞からなる扁平上皮癌であった.子宮頸癌の皮下転移は比較的まれで, 現在までに報告された症例は検索した範囲では31例をみるにすぎない.症例を供覧し文献的考察を加え報告する.

DOI： 10.2974/kmj1951.46.67

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記述言語：英語   出版者・発行元：the Japan Radiation Research Society  

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その他リンク： https://projects.repo.nii.ac.jp/?action=repository_uri&item_id=234870

記述言語：日本語  

J-GLOBAL

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語  

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記述言語：日本語  

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記述言語：日本語  

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記述言語：英語   出版者・発行元：ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS  

Retrospective analysis was carried out from the records of 108 patients with carcinoma of the uterine cervix treated with postoperative external whole pelvic irradiation (EWPI) followed by intravaginal tone boost with an electron beam to the vaginal cuff (IVCB) to evaluate the efficacy of this method. The 5-year cause-specific survival rates were 89% for 89 patients undergoing prophylactic radiation therapy and 56% for 19 patients undergoing salvage radiation therapy (P &lt; 0.001). The 5-year survival rates were 62% for 11 patients with macroscopic residual tumors and 41% for 8 patients with microscopic residual tumors. Of the patients with pelvic lymph node (PLN) involvement, incidences of intrapelvic recurrence, extrapelvic recurrence, and distant metastases were 12, 9, and 3%, respectively. The prognosis for patients without PLN metastasis was significantly better than that for patients with PLN metastasis in the prophylactic radiation therapy group (P &lt; 0.001), Recurrent tumors at the vaginal cuff were observed in only 2 patients in the prophylactic radiation therapy group. Vesicovaginal fistula was observed in 4 patients. Only 1 patient developed Grade 2 rectal complications. No other severe complications were observed. IVCB following EWPI is a safe and effective postoperative radiation therapy technique for patients with cervical cancer. (C) 1995 Academic Press, Inc.

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記述言語：英語   出版者・発行元：FOUNDATION PROMOTION CANCER RESEARCH  

Retrospective analysis was performed to evaluate the prognostic factors for loco-regional control and the results of re-irradiation for 28 patients with recurrent, poorly-differentiated squamous cell carcinoma (PDSCC) of the nasopharynx. Twenty-four of them received re-irradiation. Local, local plus regional and regional recurrences were observed in 19, five and four patients, respectively. Except for three patients, all had Stage IV disease at the initial diagnosis. The only parameters influencing loco-regional recurrence were T and N stage categories. The median latent period from initial treatment to recurrence was 18.5 (range, 2-100) months. There was no difference in latent period by first recurrence site, although recurrent tumors confined to the nasopharynx or those only regionally developed had a longer latent period. Only four patients developed secondary distant bone metastases with a median latency of three months from loco-regional relapse. The patients with local recurrent tumors confined to the nasopharynx, and those with regional recurrences only, could be salvaged by re-irradiation, with five-year survival rates of 44 and 100%, respectively. Five of 28 patients (18%) developed severe chronic radiation sequelae: cerebrospinal complications in four patients, bilateral neck fibrosis in one. We conclude that recurrent PDSCC of the nasopharynx can be controlled by re-irradiation with some success. Radiation therapy techniques must, however, be carefully planned in order to avoid the severe late post re-irradiation sequelae. For patients with advanced non-curable local recurrences, palliative care should be recommended instead of agressive re-irradiation.

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記述言語：日本語   出版者・発行元：日本肺癌学会  

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