Updated on 2025/01/28

写真a

 
Tateno Amane
 
Affiliation
Graduate School of Medicine, Department of Neuropsychiatry, Graduate Shool Professor
Nippon Medical School Hospital, Department of Neuropsychiatry, Graduate Shool Professor
Title
Graduate Shool Professor
External link

Degree

  • 医学博士 ( 日本医科大学 )

Research Interests

  • brain imaging

  • clinical psychaitry

  • 脳画像

  • 臨床精神医学

Research Areas

  • Life Science / Neuroscience-general

  • Life Science / Psychiatry

Research History

  • Nippon Medical School   Department of Neuropsychiatry   Graduate School Professor

    2021.4

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  • Nippon Medical School   Department of Neuropsychiatry   Associate Professor

    2013.4 - 2021.3

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Papers

  • Supplementary motor area is deactivated during mental rotation tasks with biomechanical constraints in fMRI

    Makoto Nomura, Michihiko Koeda, Yumiko Ikeda, Amane Tateno, Ryosuke Arakawa, Yoichiro Aoyagi

    Frontiers in Human Neuroscience   18   2024.10

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    Publishing type:Research paper (scientific journal)   Publisher:Frontiers Media SA  

    Introduction

    Mental rotation (MR) tasks of body parts involve anatomically interconnected brain systems. The systems are implicated in sensorimotor information integration and activate cortical motor-related areas, corresponding to the execution of similar motor tasks. In this study, we aimed to investigate the effect of varying the angle in the hand MR task on cerebral activation of the motor-related areas.

    Methods

    Twenty healthy right-handed participants were recruited. We investigated cerebral activation while each participant decided whether a hand-palm image, rotated by 0°, 90°, 180°, and 270°, was a right or left hand.

    Results and discussion

    A significant negative correlation between the angle and brain activity was observed in the right and left supplementary motor area (SMA) and right posterior anterior cingulate gyrus. The SMA was inactivated with 180°- or 270°-rotated images in the regions of interest analysis. 180°- and 270°-rotated palms would be biomechanically difficult to position; thus, SMA deactivation may be closely associated with biomechanical constraints. This study provided novel findings regarding the neurophysiological mechanisms of motor imagery and may be useful in developing treatment plans using MR tasks during patient rehabilitation.

    DOI: 10.3389/fnhum.2024.1455587

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  • A randomized placebo controlled trial demonstrates the effect of dl-methylephedrine on brain functions is weaker than that of pseudoephedrine

    Takeshi Sakayori, Yumiko Ikeda, Ryosuke Arakawa, Tsuyoshi Nogami, Amane Tateno

    Scientific Reports   14 ( 1 )   2024.9

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    DOI: 10.1038/s41598-024-71851-z

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    Other Link: https://www.nature.com/articles/s41598-024-71851-z

  • Tramadol effects on brain activity during cognitive and emotional empathy for pain: a randomized controlled study

    Chihiro Suzuki, Yumiko Ikeda, Amane Tateno, Yoshiro Okubo, Haruhisa Fukayama, Hidenori Suzuki

    The Journal of Pain   104672 - 104672   2024.9

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    Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    DOI: 10.1016/j.jpain.2024.104672

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  • New-onset schizophrenia in an adolescent after COVID-19.

    Masatsugu Ishii, Kakusho C Nakajima-Ohyama, Hayato Saito, Tomoyuki Ohya, Shotaro Uchiyama, Mizuho Takahashi, Masanori Sakamaki, Akihiro Watanabe, Jun-Ichi Inoue, Tetsuro Sekine, Amane Tateno, Yasuhiro Kishi

    Journal of Nippon Medical School = Nippon Ika Daigaku zasshi   2024.6

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    Schizophrenia develops during adolescence. Maternal infections during the fetal period increase the incidence of schizophrenia in children, which suggests that the pathogenesis involves neuroinflammation. Here, we report a case of new-onset schizophrenia in a 16-year-old boy after COVID-19. After developing COVID-19, he entered a catatonic state 4 days later and was hospitalized. Benzodiazepines alleviated his catatonia, but hallucinations and delusions persisted. Encephalitis and epilepsy were excluded by magnetic resonance imaging (MRI), encephalography, and cerebrospinal fluid examination. Psychosis persisted after the virus titer declined and the inflammatory response subsided. Moreover, the patient exhibited delusions of control-a Schneider's first-rank symptom. Schizophrenia was diagnosed, and olanzapine improved his symptoms. He had a brief history of insomnia before COVID-19 but his symptoms did not satisfy the ultra-high-risk criteria. However, COVID-19 may have facilitated development of schizophrenia through neuroinflammation and volume reduction in the gray matter of the right medial temporal lobe. This case demonstrates that infectious diseases in adolescents should be carefully managed, to prevent schizophrenia.

    DOI: 10.1272/jnms.JNMS.2025_92-301

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  • 老年期反復性うつ病が前駆したアルツハイマー型認知症の1例

    比留間 達之, 大矢 智之, 山本 憲, 坂寄 健, 野上 毅, 松本 有紀子, 舘野 周

    精神神経学雑誌   126 ( 5 )   339 - 339   2024.5

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    Language:Japanese   Publisher:(公社)日本精神神経学会  

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  • 発達障害,うつ病を伴う高度肥満患者に対し肥満減量手術を検討した1例

    川端 留里佐, 秋山 友美, 山本 憲, 松本 有紀子, 舘野 周

    精神神経学雑誌   126 ( 5 )   338 - 338   2024.5

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  • Cerebral activation caused by dental sounds: a functional magnetic resonance imaging study

    Hiroyuki Karibe, Michihiko Koeda, Yuichi Kato, Tomoko Hama, Satoshi Tanaka, Amane Tateno, Hidenori Suzuki, Yoshiro Okubo

    Odontology   2024.2

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    Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    Abstract

    Dental drilling sounds can induce anxiety in some patients. This study aimed to use functional magnetic resonance imaging (fMRI) to assess the relationship between dental fear and auditory stimuli. Thirty-four right-handed individuals (21 women and 13 men; average age, 31.2 years) were selected. The level of dental fear was assessed using the dental fear survey (DFS). Based on a threshold DFS score > 52, participants were categorized into two groups: dental fear (DF) group (n = 12) and control group (n = 22). Two types of stimuli were presented in a single session: dental and neutral sounds. Cerebral activation during the presentation of these sounds was evaluated using contrast-enhanced blood oxygenation level-dependent fMRI. In the DF group, dental sounds induced significantly stronger activation in the left inferior frontal gyrus and left caudate nucleus (one-sample t test, P < 0.001). In contrast, in the control group, significantly stronger activation was observed in the bilateral Heschl’s gyri and left middle frontal gyrus (one-sample t test, P < 0.001). Additionally, a two-sample t test revealed that dental sounds induced a significantly stronger activation in the left caudate nucleus in the DF group than in the control group (P < 0.005). These findings suggest that the cerebral activation pattern in individuals with DF differs from that in controls. Increased activation of subcortical regions may be associated with sound memory during dental treatment.

    DOI: 10.1007/s10266-023-00898-7

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    Other Link: https://link.springer.com/article/10.1007/s10266-023-00898-7/fulltext.html

  • 電気けいれん療法(ECT)における再発とドーパミントランスポーター(DAT)結合能の関連性

    内山 翔太郎, 大矢 智之, 坂寄 健, 野上 毅, 舘野 周, 荒川 亮介

    日本医科大学医学会雑誌   19 ( 4 )   398 - 398   2023.12

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    Language:Japanese   Publisher:日本医科大学医学会  

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  • コロナ禍に日本医科大学附属病院高度救命救急センターに入院した自殺未遂者の特徴

    佐々木 瞭, 大高 靖史, 成重 竜一郎, 山本 憲, 野上 毅, 舘野 周

    総合病院精神医学   35 ( Suppl. )   S - 209   2023.11

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    Language:Japanese   Publisher:(一社)日本総合病院精神医学会  

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  • 摂食障害・依存症におけるケトン体の役割についての基盤的研究

    大山 覚照, 坂井 敦, 早川 清雄, 明野 薫, 内山 翔太郎, 岸 泰宏, 荒川 亮介, 舘野 周

    総合病院精神医学   35 ( Suppl. )   S - 160   2023.11

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  • 自閉症スペクトラム障害傾向のある産後うつ患者に対する心理支援を行った一例

    秋山 友美, 明野 薫, 舘野 周

    総合病院精神医学   35 ( Suppl. )   S - 200   2023.11

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  • 外来患者における超短時間作用型ベンゾジアゼピン受容体作動薬使用時の睡眠随伴症状の異常行動発現の調査

    齋藤 晴紀, 山口 裕太郎, 菅沼 慶, 山本 憲, 坂寄 健, 野上 毅, 下田 健吾, 舘野 周

    総合病院精神医学   35 ( 3 )   277 - 277   2023.7

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  • 短時間作用型睡眠薬使用時の睡眠随伴症状の異常行動発現の頻度について

    齋藤 晴紀, 山口 裕太郎, 菅沼 慶, 山本 憲, 坂寄 健, 野上 毅, 下田 健吾, 舘野 周

    精神神経学雑誌   ( 2023特別号 )   S423 - S423   2023.6

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  • 日本医科大学付属病院で施行した高齢者に対するm-ECTの有効性と安全性に関する報告

    大矢 智之, 坂寄 健, 山本 憲, 野上 毅, 舘野 周

    精神神経学雑誌   ( 2023特別号 )   S696 - S696   2023.6

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  • Depression as a Prodromal Symptom of Neurodegenerative Diseases.

    Amane Tateno, Tsuyoshi Nogami, Takeshi Sakayori, Ken Yamamoto, Yoshiro Okubo

    Journal of Nippon Medical School = Nippon Ika Daigaku zasshi   90 ( 2 )   157 - 164   2023

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    Neurodegenerative diseases can manifest as psychiatric symptoms in the prodromal phase, before the onset of core symptoms such as neurological, motor, and cognitive symptoms. Positron emission tomography (PET) has made it possible to detect the pathology of some neurodegenerative diseases in vivo. Many studies have indicated that depression is a preclinical symptom of neurodegenerative diseases. Approximately 10% of non-demented participants with depression developed Alzheimer's disease (AD) during the follow-up period. The prevalence of depression/dysphoria was 42.9% in the preclinical stage of dementia with Lewy bodies. Depression was present in 33.3% of patients with preclinical behavioral-variant frontotemporal lobar degeneration. Approximately 10% of patients had a history of depression at the time of diagnosis with Parkinson's disease. PET studies have revealed the pathology of neurodegenerative diseases in some cases of geriatric depression. Increased brain amyloid-beta deposition in late-onset depression is a possible reflection of prodromal AD. The severity of depression was significantly associated with greater inferior temporal tau and marginally associated with greater entorhinal cortex tau, and depression was associated with significantly greater mean cortical tau deposition. Thus, the presence of depression as a preclinical/prodromal symptom of neurodegenerative diseases has been demonstrated by epidemiological, pathological, and biomarker studies. A growing body of evidence from PET studies indicates that some cases of geriatric depression have pathologies of degenerative neurological disease. In the future, it is expected that PET will be utilized as an imaging biomarker for diagnosis of psychiatric disorders and development of new therapeutic agents.

    DOI: 10.1272/jnms.JNMS.2023_90-216

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  • Feasibility and acceptability of cognitive behavioural therapy in older Japanese people with cognitive decline: a single-arm intervention

    Masami Kashimura, Akiko Ishiwata, Amane Tateno, Aimee Spector

    COGNITIVE BEHAVIOUR THERAPIST   15   2022.12

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:CAMBRIDGE UNIV PRESS  

    Studies have shown that cognitive behavioural therapy (CBT) for older people with cognitive decline and depression/anxiety improves negative moods. However, CBT research focusing on this population in Japan is limited. This study aimed to evaluate the feasibility of a cognitive behavioural program for people with cognitive decline. Sixteen Japanese patients with mild dementia (n = 3) and mild cognitive impairment (MCI, n = 13) participated in the study. A single-arm, pre-post study was implemented in two hospitals in Japan. The CBT program included eight bi-weekly sessions. The feasibility outcomes (satisfaction, understanding and usefulness) were measured immediately after completing the sessions, and depression, anxiety, quality of life (QOL), neuropsychiatric symptoms, and caregiver burden were measured at three time points (i.e. before, immediately after, and 3-month follow-up). Ten MCI participants attended all sessions and the mean patient satisfaction scores using the Client Satisfaction Questionnaire were 31.0 +/- 10.05 out of 32. Linear mixed model analyses demonstrated that the time effect was significant for depression (d = 1.62), anxiety (d = 1.39), and QOL (d = 1.00) for the patients, and significant for anxiety (d = 1.08) for their caregivers. The study found that this CBT program is feasible and acceptable for older Japanese people with cognitive decline. The program also improved patients' QOL, anxiety and depressive symptoms, and decreased caregivers' anxiety. Key learning aims Recently, studies have shown that CBT for older people living with dementia has been effective in treating their depression and anxiety. However, evidence for the efficacy of CBT and other curative or care options for people living with dementia is limited in Japan. We studied a short-period CBT program and found that it was likely to be feasible and acceptable for use among older Japanese people with mild cognitive impairment, that it may improve negative mood among this group, and that it may lessen the care burden for caregivers. Furthermore, we found that caregiver involvement in the implementation of CBT for older people may be effective in improving the mood of family members.

    DOI: 10.1017/S1754470X22000514

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  • 市販の向知薬が脳内ドパミントランスポーターに与える影響

    大矢 智之, 坂寄 健, 内山 翔太朗, 野上 毅, 舘野 周, 池田 裕美子, 荒川 亮介

    日本医科大学医学会雑誌   18 ( 4 )   447 - 447   2022.12

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  • 発達障害特性のある妊産婦の心理面接の組み立て

    秋山 友美, 明野 薫, 舘野 周

    総合病院精神医学   34 ( Suppl. )   S - 220   2022.10

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  • 精神疾患を有する妊産婦支援の当科の取り組みについて

    明野 薫, 秋山 友美, 舘野 周

    総合病院精神医学   34 ( Suppl. )   S - 182   2022.10

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  • Effect of DL-Methylephedrine on Dopamine Transporter Using Positron Emission Tomography With [18F]FE-PE2I

    Tsuyoshi Nogami, Ryosuke Arakawa, Takeshi Sakayori, Yumiko Ikeda, Yoshiro Okubo, Amane Tateno

    Frontiers in Psychiatry   13   2022.5

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    Rationale

    Since ephedrine has a dopamine transporter (DAT) inhibitory effect similar to amphetamine, dl-methylephedrine, a derivative of ephedrine, is considered to have the characteristics of a central nervous system stimulant due to the DAT inhibitory effect. For example, the World Anti-Doping Agency categorizes dl-methylephedrine as a stimulant in the prohibited list for competitions. Assuming to have the same effect as ephedrine, the urinary concentration of dl-methylephedrine is regulated below 10 μg/mL, as is ephedrine. However, the extent to which dl-methylephedrine affects brain function is not yet fully understood.

    Objectives

    The purpose of this study was to evaluate DAT occupancy by a single oral administration of a daily dose of dl-methylephedrine using positron emission tomography (PET) with [18F]FE-PE2I to characterize its stimulatory effect on the central nervous system.

    Methods

    Nine healthy male volunteers were enrolled in the study. The experiments were designed as a placebo-controlled randomized double-blind crossover comparative study. After the first PET scan in a drug-free state, the second and third PET scans were performed with randomized dosing at 60 mg of dl-methylephedrine or placebo. The plasma and urine concentrations of dl-methylephedrine were measured just before and after the PET scans, respectively.

    Results

    Mean urine and plasma concentrations of dl-methylephedrine were 13.9 μg/mL and 215.2 ng/mL, respectively. Mean DAT occupancy in the caudate was 4.4% for dl-methylephedrine and 1.2% for placebo. Mean DAT occupancy in the putamen was 3.6% for dl-methylephedrine and 0.5% for placebo. There was no significant difference of DAT occupancies between the groups.

    Conclusion

    In this study, the urinary concentration of dl-methylephedrine (13.9 μg/mL) was higher than the prohibited reference value (10.0 μg/mL), and there was no significant difference in DAT occupancy between dl-methylephedrine and placebo. These findings suggest that a clinical daily dose of dl-methylephedrine may exceed the doping regulation value according to urine concentration; however, it was considered that at least the central excitatory effect mediated by DAT inhibition was not observed at the daily dose of dl-methylephedrine.

    DOI: 10.3389/fpsyt.2022.799319

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  • Suicide decline and improved psychiatric treatment status: longitudinal survey of suicides and serious suicide attempters in Tokyo. International journal

    Yasushi Otaka, Ryosuke Arakawa, Ryuichiro Narishige, Yoshiro Okubo, Amane Tateno

    BMC psychiatry   22 ( 1 )   221 - 221   2022.3

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    BACKGROUND: Connecting individuals in need of psychiatric treatment with adequate medical services has been a major strategy for suicide prevention in Japan. By investigating serious suicide attempters admitted to our Critical Care Medical Center (CCM), we aimed to examine longitudinal changes in the psychiatric treatment status of high-risk suicidal individuals, and to explore the association between any improvement in psychiatric treatment status and suicide decline. METHODS: Subjects from two periods, 2006-2011 and 2012-2017, were enrolled. We collected the data of 32,252 suicides in Tokyo from police reports and the data of 942 suicide attempters admitted to CCM from medical records. Data were annually collected by both age and gender for the number of suicide completers, the number of suicide attempters, and the psychiatric treatment rates, respectively. ANOVA and t-test were used to examine whether there were differences in the number of suicides and attempers between the two periods. The difference in psychiatric treatment rate between the two periods was examined by chi-square test. Additionally, we used Pearson's correlation coefficient to analyze any correlation between annual treatment rate and the number of suicide completers in subgroups with altered psychiatric treatment rates. RESULTS: The number of suicide attempters in the 20-39-year age group of decreased together with the number of suicides. Psychiatric treatment rates of male attempters aged 20-59 years improved significantly from 48.7 to 70.6% and this improvement correlated with a decrease in suicides. However, psychiatric treatment rates in the elderly, which have the highest number of suicides in both genders, did not improve and remain low. CONCLUSIONS: The number of suicide attempters, as well as that of suicides, decreased in Tokyo. Improvement of psychiatric treatment status in high-risk suicidal male adults may have contributed to the reduction of suicides in Tokyo. However, the continuing low rate of psychiatric treatment in the elderly is a pressing issue for future suicide prevention.

    DOI: 10.1186/s12888-022-03866-7

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  • Factors Regarding Suicide Decline in Japan: A Longitudinal Study on Psychiatric Diagnosis of Serious Suicide Attempters.

    Yasushi Otaka, Ryosuke Arakawa, Ryuichiro Narishige, Yoshiro Okubo, Amane Tateno

    Journal of Nippon Medical School = Nippon Ika Daigaku zasshi   89 ( 4 )   392 - 398   2022

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    BACKGROUND: The number of suicides in Japan decreased during the period from 2012 through 2019. Because data on factors associated with this decline are limited, we conducted a retrospective longitudinal study of psychiatric diagnoses of serious suicide attempters before 2012 and after 2019. METHODS: Serious suicide attempters admitted to the critical care medicine (CCM) department of Nippon Medical School Hospital between 2006 and 2017 were included and classified as those before and after the suicide decline in 2012. Chi-square test and residual analysis were used to analyze changes in the proportion of suicide attempters among all patients admitted to CCM and to examine differences in the proportion of psychiatric diagnoses. RESULTS: The proportion of suicide attempters among CCM hospitalized patients decreased overall (χ2 (1) =18.29, p<.01). The proportion of psychiatric diagnoses changed significantly (χ2 (8) =62.21, p<0.001); specifically, it decreased for schizophrenia (residual: -2.28), depressive disorders (residual: -5.39), persistent mood disorders (residual: -3.58), and reaction to stress disorders (residual: -2.73). Depressive disorders decreased and had a large contribution ratio in both sexes. CONCLUSIONS: The decrease in the proportion of attempted suicides among patients admitted to CCM was consistent with the decline in suicides in Japan. Analysis by psychiatric diagnosis confirmed a significant decrease in the proportion of suicide attempts associated with depressive disorders, schizophrenia, and reaction to stress disorders, which were the most common disorders associated with attempted suicide. Depressive disorders made the greatest contribution to the reduction in suicide attempts.

    DOI: 10.1272/jnms.JNMS.2022_89-405

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  • A positron emission tomography study of the serotonin1B receptor effect of electroconvulsive therapy for severe major depressive episodes. International journal

    Mikael Tiger, Martin Gärde, Amane Tateno, Granville J Matheson, Takeshi Sakayori, Tsuyoshi Nogami, Hiroki Moriya, Katarina Varnäs, Ryosuke Arakawa, Yoshiro Okubo

    Journal of affective disorders   294   645 - 651   2021.11

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    BACKGROUND: Electroconvulsive therapy (ECT) is an effective treatment for depressive disorders, although its molecular mechanism of action is unknown. The serotonin 1B (5-HT1B) receptor is a potential target for treatment of depression and low 5-HT1B receptor binding in limbic regions has been reported in previous positron emission tomography (PET) studies of depression. METHODS: The objective of this longitudinal PET study was to examine the effect of ECT for depression on 5-HT1B receptor binding. Fifteen hospitalized patients with major depressive episodes were examined with PET and the 5-HT1B receptor selective radioligand [11C]AZ10419369, before and after ECT. Fifteen controls matched for age and sex were examined. Limbic regions with previously reported low 5-HT1B receptor binding in depression and a dorsal brain stem region were selected. RESULTS: Thirteen patients completed the study according to protocol. Eleven out of thirteen patients responded to ECT. 5-HT1B receptor binding in hippocampus increased with 30 % after ECT (p=0.021). Using linear mixed effects modelling, we observed increases in 5-HT1B receptor binding following ECT with a moderate to large effect size, which did not differ significantly between regions. In an exploratory analysis, strong correlations between changes in 5-HT1B receptor binding and agitation scores on the Hamilton Depression Rating Scale after ECT were observed. LIMITATIONS: Albeit representative of a PET study, the sample size is still small and there are potential confounding effects of medication. CONCLUSIONS: Increased 5-HT1B receptor binding was observed following ECT for depression, corresponding to previous findings of increased 5-HT1B receptor binding in hippocampus after rapid acting ketamine for treatment resistant depression.

    DOI: 10.1016/j.jad.2021.07.060

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  • Modafinil decreased thalamic activation in auditory emotional processing: A randomized controlled functional magnetic resonance imaging study

    Tomoko Hama, Michihiko Koeda, Yumiko Ikeda, Amane Tateno, Tokuhiro Kawara, Hidenori Suzuki, Yoshiro Okubo

    Journal of Nippon Medical School   88 ( 5 )   485 - 495   2021.10

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    Publishing type:Research paper (scientific journal)   Publisher:Medical Association of Nippon Medical School  

    DOI: 10.1272/jnms.jnms.2021_88-607

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  • 老年期うつ病における血管性うつ病と非血管性うつ病の形態学的脳変化の相違

    下田 健吾, 木村 真人, 舘野 周, 大久保 善朗

    精神神経学雑誌   ( 2021特別号 )   S630 - S630   2021.9

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  • 生殖医療治療中のうつ病に対する認知行動療法

    秋山 友美, 明野 薫, 舘野 周

    日本うつ病学会総会・日本認知療法・認知行動療法学会プログラム・抄録集   18回・21回   332 - 332   2021.7

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    Language:Japanese   Publisher:日本うつ病学会・日本認知療法・認知行動療法学会  

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  • Effects of anodal transcranial direct current stimulation on implicit motor learning and language‐related brain function: An fMRI study

    Soichiro Nakashima, Michihiko Koeda, Yumiko Ikeda, Tomoko Hama, Takuya Funayama, Tomomi Akiyama, Ryosuke Arakawa, Amane Tateno, Hidenori Suzuki, Yoshiro Okubo

    Psychiatry and Clinical Neurosciences   75 ( 6 )   200 - 207   2021.6

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    Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    DOI: 10.1111/pcn.13208

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    Other Link: https://onlinelibrary.wiley.com/doi/full-xml/10.1111/pcn.13208

  • Evaluation of dopamine D3 receptor occupancy by blonanserin using [11C]-(+)-PHNO in schizophrenia patients

    Takeshi Sakayori, Amane Tateno, Ryosuke Arakawa, Woo-chan Kim, Yoshiro Okubo

    Psychopharmacology   238 ( 5 )   1343 - 1350   2021.5

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    Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    Abstract

    Rationale

    Unlike other antipsychotics, our previous positron emission tomography (PET) study demonstrated that a single dose of blonanserin occupied dopamine D3 as well as dopamine D2 receptors in healthy subjects. However, there has been no study concerning the continued use of blonanserin.

    Objectives

    We examined D2 and D3 receptor occupancies in patients with schizophrenia who had been treated with blonanserin.

    Methods

    Thirteen patients with schizophrenia participated. PET examinations were performed on patients treated with clinical dosage of blonanserin or olanzapine alone. A crossover design was used in which seven patients switched drugs after the first scan, and PET examinations were conducted again. D2 and D3 receptor occupancies were evaluated by [11C]-(+)-PHNO. We used nondisplaceable binding potential (BPND) of 6 healthy subjects which we previously reported as baseline. To consider the effect of upregulation of D3 receptor by continued use of antipsychotics, D3 receptor occupancy by blonanserin in seven subjects who completed 2 PET scans were re-analyzed by using BPND of olanzapine condition as baseline.

    Results

    Average occupancy by olanzapine (10.8 ± 6.0 mg/day) was as follows: caudate 32.8 ± 18.3%, putamen 26.3 ± 18.2%, globus pallidus − 33.7 ± 34.9%, substantia nigra − 112.8 ± 90.7%. Average occupancy by blonanserin (12.8 ± 5.6 mg/day) was as follows: caudate 61.0 ± 8.3%, putamen 55.5 ± 9.5%, globus pallidus 48.9 ± 12.4%, substantia nigra 34.0 ± 20.6%. EC50 was 0.30 ng/mL for D2 receptor for caudate and putamen (df = 19, p &lt; 0.0001) and 0.70 ng/mL for D3 receptor for globus pallidus and substantia nigra (df = 19, p &lt; 0.0001). EC50 for D3 receptor of blonanserin changed to 0.22 ng/mL (df = 13, p = 0.0041) when we used BPND of olanzapine condition as baseline.

    Conclusions

    Our study confirmed that blonanserin occupied both D2 and D3 receptors in patients with schizophrenia.

    DOI: 10.1007/s00213-020-05698-3

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  • Bupropion increases cerebral activation in auditory affective processing: A randomized controlled fMRI study

    Tomoko Hama, Michihiko Koeda, Yumiko Ikeda, Amane Tateno, Tokuhiro Kawara, Hidenori Suzuki, Yoshiro Okubo

    Neuroscience Letters   749   135716 - 135716   2021.4

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  • Psychometric properties of the Japanese version of the Geriatric Anxiety Inventory for community‐dwelling older adults

    Masami Kashimura, Kenichiro Ishizu, Takaki Fukumori, Akiko Ishiwata, Amane Tateno, Toshiaki Nomura, Nancy A. Pachana

    Psychogeriatrics   2021.3

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    DOI: 10.1111/psyg.12683

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  • Striatal Dopamine D2 Receptor Occupancy Induced by Daily Application of Blonanserin Transdermal Patches: Phase II Study in Japanese Patients With Schizophrenia

    Hironori Nishibe, Amane Tateno, Takeshi Sakayori, Masahiro Yamamoto, WooChan Kim, Hiroyoshi Kakuyama, Yoshiro Okubo

    International Journal of Neuropsychopharmacology   24 ( 2 )   108 - 117   2021.2

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    Abstract

    Background

    Transdermal antipsychotic patch formulations offer potential benefits, including improved adherence. This study investigated the striatal dopamine D2 receptor occupancy with daily blonanserin transdermal patch application.

    Methods

    This open-label, phase II study enrolled 18 Japanese outpatients (20 to &amp;lt;65 years) with schizophrenia (DSM-IV-TR criteria; total Positive and Negative Syndrome Scale score &amp;lt;120 at screening) treated with blonanserin 8-mg or 16-mg tablets. Patients continued tablets for 2–4 weeks at their current dose and were then assigned to once-daily blonanserin patches (10/20/40/60/80 mg daily) for 2–4 weeks based on the oral dose. [11C]raclopride positron emission tomography scanning determined blonanserin striatal dopamine D2 receptor occupancy (primary endpoint). Secondary endpoints included assessment of receptor occupancy by dose, changes in Positive and Negative Syndrome Scale and Clinical Global Impressions-Severity of Illness-Severity scores, patient attitudes towards adherence, and patch adhesiveness.

    Results

    Of 18 patients who started the blonanserin tablet treatment period, 14 patients completed treatment. Mean D2 receptor occupancy for blonanserin tablets 8 mg/d (59.2%, n = 5) and 16 mg/d (66.3%, n = 9) was within the values for blonanserin patches: 10 mg/d (33.3%, n = 3), 20 mg/d (29.9%, n = 2), 40 mg/d (61.2%, n = 3), 60 mg/d (59.0%, n = 3), and 80 mg/d (69.9%, n = 3). Occupancy generally increased with increasing blonanserin dose for both formulations with the half maximal receptor occupancy for tablets and patches associated with doses of 6.9 mg/d and 31.9 mg/d, respectively. Diurnal variability in occupancy was lower during transdermal patch treatment than during tablet treatment. Blonanserin transdermal patches were well tolerated with no major safety concerns.

    Conclusions

    Blonanserin patches (40/80 mg/d) have lower diurnal variability in occupancy than blonanserin tablets (8/16 mg/d), and patches at doses of 40 mg/d and 80 mg/d appear to be a suitable alternative for blonanserin tablets at doses of 8 mg/d and 16 mg/d, respectively. Blonanserin patches represent a potential new treatment option for patients with schizophrenia.

    Trial registry

    JAPIC Clinical Trials Information registry (www.clinicaltrials.jp; JapicCTI-No: JapicCTI-121914).

    DOI: 10.1093/ijnp/pyaa071

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  • Multi-Atlas MRI-Based Striatum Segmentation for 123I-FP-CIT SPECT (DAT-SPECT) Compared With the Bolt Method and SPECT-Atlas-Based Segmentation Method Toward the Accurate Diagnosis of Parkinson's Disease/Syndrome. International journal

    Koji Sohara, Tetsuro Sekine, Amane Tateno, Sunao Mizumura, Masaya Suda, Takeshi Sakayori, Yoshiro Okubo, Shin-Ichiro Kumita

    Frontiers in medicine   8   662233 - 662233   2021

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    Aims: This study aimed to analyze the performance of multi-atlas MRI-based parcellation for 123I-FP-CIT SPECT (DAT-SPECT) in healthy volunteers. The proposed method was compared with the SPECT-atlas-based and Bolt methods. 18F-FE-PE2I-PET (DAT-PET) was used as a reference. Methods: Thirty healthy subjects underwent DAT-SPECT, DAT-PET, and 3D-T1WI-MRI. We calculated the striatum uptake ratio (SUR/SBR), caudate uptake ratio (CUR), and putamen uptake ratio (PUR) for DAT-SPECT using the multi-atlas MRI-based method, SPECT-atlas-based method, and Bolt method. In the multi-atlas MRI-based method, the cerebellum, occipital cortex, and whole-brain were used as reference regions. The correlation of age with DAT-SPECT activity and the correlations of SUR/SBR, CUR, and PUR between DAT-SPECT and DAT-PET were calculated by each of the three methods. Results: The correlation between age and SUR/SBR for DAT-SPECT based on the multi-atlas MRI-based method was comparable to that based on the SPECT-atlas-based method (r = -0.441 to -0.496 vs. -0.488). The highest correlation between DAT-SPECT and DAT-PET was observed using the multi-atlas MRI-based method with the occipital lobe defined as the reference region compared with the SPECT-atlas-based and Bolt methods (SUR, CUR, and PUR: 0.687, 0.723, and 0.676 vs. 0.698, 0.660, and 0.616 vs. 0.655). Conclusion: Multi-atlas MRI-based parcellation with the occipital lobe defined as the reference region was at least comparable to the clinical methods.

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  • 軽度認知障害から認知症への移行におけるうつ病とアミロイドベータの関連

    山本 憲, 坂寄 健, 荒川 亮介, 舘野 周, 大久保 善朗

    精神神経学雑誌   ( 2020特別号 )   S323 - S323   2020.9

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  • Low dopamine transporter binding in the nucleus accumbens in geriatric patients with severe depression. International journal

    Hiroki Moriya, Mikael Tiger, Amane Tateno, Takeshi Sakayori, Takahiro Masuoka, WooChan Kim, Ryosuke Arakawa, Yoshiro Okubo

    Psychiatry and clinical neurosciences   74 ( 8 )   424 - 430   2020.8

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    AIM: Dysfunction of dopaminergic neurons in the central nervous system is considered to be related to major depressive disorder (MDD). Especially, MDD in geriatric patients is characterized by anhedonia, which is assumed to be associated with reduced dopamine neurotransmission in the reward system. Dopamine transporter (DAT) is considered to reflect the function of the dopamine nerve system. However, previous DAT imaging studies using single photon emission computed tomography or positron emission tomography (PET) have shown inconsistent results. The radioligand [18 F]FE-PE2I for PET enables more precise evaluation of DAT availability. Hence, we aimed to evaluate the DAT availability in geriatric patients with MDD using [18 F]FE-PE2I. METHODS: Eleven geriatric patients with severe MDD and 27 healthy controls underwent PET with [18 F]FE-PE2I, which has high affinity and selectivity for DAT. Binding potentials (BPND ) in the striatum (caudate and putamen), nucleus accumbens (NAc), and substantia nigra were calculated. BPND values were compared between MDD patients and healthy controls. RESULTS: MDD patients showed significantly lower DAT BPND in the NAc (P = 0.009), and there was a trend of lower BPND in the putamen (P = 0.032) compared to controls. CONCLUSION: We found low DAT in the NAc and putamen in geriatric patients with severe MDD, which could be related to dysregulation of the reward system.

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  • Electroconvulsive therapy decreases striatal dopamine transporter binding in patients with depression: A positron emission tomography study with [18F]FE-PE2I. International journal

    Takahiro Masuoka, Amane Tateno, Takeshi Sakayori, Mikael Tiger, WooChan Kim, Hiroki Moriya, Satoshi Ueda, Ryosuke Arakawa, Yoshiro Okubo

    Psychiatry research. Neuroimaging   301   111086 - 111086   2020.7

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    Electroconvulsive therapy (ECT) is an effective treatment for major depression. Previous studies suggested that dopaminergic neurotransmission plays a crucial role in the mechanism of the action of ECT. Since dopamine transporters (DAT) regulate extracellular dopamine concentration, DAT represents an interesting target for the study of the mechanism of action of ECT. Eight inpatients (7 patients with major depressive disorder and 1 patient with bipolar disorder with a DSM-IV diagnosis) received a series of 7-15(11.3±5.2) bilateral ECT sessions.The severity of symptoms was assessed using the 21-item Hamilton Depression Rating Scale (HDRS) and Clinical Global Impression-Severity (CGI-S). All patients were examined with [18F]FE-PE2I positron emission tomography (PET) at pre-ECT, after the 10th ECT, and at post-ECT. Striatal DAT-binding potential (BPND) of all patients was reduced, with an average change ratio of DAT-BPND of -13.1±5.6%. In the 2 cases with 15 ECT sessions, the ratio change of DAT-BPND after the 15th ECT was larger than that after the 10th ECT. Also, HDRS and CGI-S were reduced. These results indicate that the dopamine nervous system is part of themechanism of action of ECT.

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  • Acceptability and feasibility of a Japanese version of STrAtegies for RelaTives (START-J): A manualized coping strategy program for family caregivers of relatives living with dementia. Reviewed International journal

    Masami Kashimura, Penny Rapaport, Toshiaki Nomura, Akiko Ishiwata, Amane Tateno, Akane Nogami, Mari Yamashita, Tomoya Kawanishi, Yoshitaka Kawashima, Shin Kitamura, Gill Livingston

    Dementia (London, England)   20 ( 3 )   1471301220919938 - 1471301220919938   2020.4

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    The rising older population in Japan is associated with a rise in cases of dementia. Support for the increased number of family caregivers of people living with dementia is crucial, as caring may negatively affect a family caregiver's health. This study seeks to evaluate the feasibility and applicability of a recently developed Japanese version of START (STrAtegies for RelaTives). START is a psychosocial coping intervention program developed in the United Kingdom that has been shown to improve caregivers' mood and quality of life in a randomized controlled trial. We made changes to START (e.g., idioms, linguistic nuance, and providing care insurance information suited for Japan) to make it culturally appropriate. Fourteen Japanese female family caregivers of relatives with mild dementia (n = 10) or mild cognitive impairment (n = 4) were referred to the study, but six were excluded owing to illness and busyness. This single-arm study had a before-after trial evaluating psychological outcomes including depression, anxiety, quality of life, and subjective care burden. The acceptance retention and satisfaction rate suggest the feasibility and acceptability of the START program; 8/14 (>55%) eligible, prospective participants consented and were included in this study, all (8/8) of whom completed all START sessions. The mean program satisfaction score was 30.25 (standard deviation = 2.25) out of a potential 32. The results suggest that it is feasible and acceptable to deliver START in Japanese and based on the results of analysis using a linear mixed model, there is initial indication that the intervention improved family caregivers' quality of life, depressive symptoms, and care burden.

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  • Cognitive Behavioral Therapy for Improving Mood in an Older Adult with Mild Cognitive Impairment: A Case Report. Reviewed

    Masami Kashimura, Toshiaki Nomura, Akiko Ishiwata, Shin Kitamura, Amane Tateno

    Journal of Nippon Medical School = Nippon Ika Daigaku zasshi   86 ( 6 )   352 - 356   2020.1

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    This study investigated the feasibility of a cognitive behavioral therapy (CBT) program for improving mood and quality of life in an older woman with mild cognitive impairment (MCI), depression, and anxiety. The program comprised eight 30-minute weekly sessions; interventions included behavioral activation, relaxation, and cognitive reconstruction, in which the patient's caregiver also participated. The patient's condition was assessed before and immediately after the intervention. After 3 and 12 months, the caregiver reported the patient's behavioral and psychological symptoms by using self-reported psychological scales for depression, anxiety, and quality of life. Although CBT helped to improve mood and quality of life in the short term (3 months), the results were not sustained over the long term (12 months). Even though improvement in psychological symptoms did not persist and only one patient with MCI was evaluated, these results suggest that CBT is a feasible nonpharmacological treatment option and provide preliminary support for wider use of CBT in Japan. CBT programs should be tailored to the needs of patients with MCI and dementia, and regular follow-up sessions should be used to evaluate program feasibility and improvement in patient mental health.

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  • 迷走神経刺激療法を行う難治症候性てんかんの精神症状についての考察

    朝山 健太郎, 岸 泰宏, 舘野 周, 大久保 善朗

    総合病院精神医学   31 ( Suppl. )   S - 230   2019.11

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  • 健常者に対するDAT SPECTとDAT PETの線条体集積比の比較検討 PNEUROとDa TView、DaTQUANTによる解析

    曽原 康二, 関根 鉄郎, 舘野 周, 水村 直, 永山 寛, 須田 匡也, 桑子 智之, 桐山 智成, 福嶋 善光, 大久保 善郎, 汲田 伸一郎

    核医学   56 ( Suppl. )   S162 - S162   2019.10

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  • Bupropion increases activation in nucleus accumbens during anticipation of monetary reward. Reviewed

    Ikeda Y, Funayama T, Tateno A, Fukayama H, Okubo Y, Suzuki H

    Psychopharmacology   2019.7

  • Clozapine投与により就労就学に繋がった若年統合失調症患者三症例

    内山 翔太郎, 朝山 健太郎, 舘野 周, 大久保 善朗

    精神神経学雑誌   ( 2019特別号 )   S474 - S474   2019.6

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  • 出産直後に発症した重症うつ病に対し、ECTにて加療したのち退院後のサポート体制を策定した1例

    大矢 智之, 増岡 孝浩, 大高 靖史, 坂寄 健, 朝山 健太郎, 舘野 周, 大久保 善朗

    精神神経学雑誌   121 ( 4 )   313 - 313   2019.4

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  • Differences in the perception of dental sounds: a preliminary study. Reviewed

    Karibe H, Koeda M, Aoyagi-Naka K, Kato Y, Tateno A, Suzuki H, Okubo Y

    Patient preference and adherence   13   1051 - 1056   2019

  • Acute Atomoxetine Selectively Modulates Encoding of Reward Value in Ventral Medial Prefrontal Cortex. Reviewed

    Suzuki C, Ikeda Y, Tateno A, Okubo Y, Fukayama H, Suzuki H

    Journal of Nippon Medical School = Nippon Ika Daigaku zasshi   86 ( 2 )   98 - 107   2019

  • Introduction to a psychoeducational program "START" for family caregivers with people living with dementia

    47 ( 47 )   15 - 29   2018.12

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  • Japanese multicenter database of healthy controls for [123I]FP-CIT SPECT. Reviewed International journal

    Hiroshi Matsuda, Miho Murata, Yohei Mukai, Kazuya Sako, Hidetoshi Ono, Hiroshi Toyama, Yoshitaka Inui, Yasuyuki Taki, Hideo Shimomura, Hiroshi Nagayama, Amane Tateno, Kenjiro Ono, Hidetomo Murakami, Atsushi Kono, Shigeki Hirano, Satoshi Kuwabara, Norihide Maikusa, Masayo Ogawa, Etsuko Imabayashi, Noriko Sato, Harumasa Takano, Jun Hatazawa, Ryosuke Takahashi

    European journal of nuclear medicine and molecular imaging   45 ( 8 )   1405 - 1416   2018.7

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    PURPOSE: The aim of this multicenter trial was to generate a [123I]FP-CIT SPECT database of healthy controls from the common SPECT systems available in Japan. METHODS: This study included 510 sets of SPECT data from 256 healthy controls (116 men and 140 women; age range, 30-83 years) acquired from eight different centers. Images were reconstructed without attenuation or scatter correction (NOACNOSC), with only attenuation correction using the Chang method (ChangACNOSC) or X-ray CT (CTACNOSC), and with both scatter and attenuation correction using the Chang method (ChangACSC) or X-ray CT (CTACSC). These SPECT images were analyzed using the Southampton method. The outcome measure was the specific binding ratio (SBR) in the striatum. These striatal SBRs were calibrated from prior experiments using a striatal phantom. RESULTS: The original SBRs gradually decreased in the order of ChangACSC, CTACSC, ChangACNOSC, CTACNOSC, and NOACNOSC. The SBRs for NOACNOSC were 46% lower than those for ChangACSC. In contrast, the calibrated SBRs were almost equal under no scatter correction (NOSC) conditions. A significant effect of age was found, with an SBR decline rate of 6.3% per decade. In the 30-39 age group, SBRs were 12.2% higher in women than in men, but this increase declined with age and was absent in the 70-79 age group. CONCLUSIONS: This study provided a large-scale quantitative database of [123I]FP-CIT SPECT scans from different scanners in healthy controls across a wide age range and with balanced sex representation. The phantom calibration effectively harmonizes SPECT data from different SPECT systems under NOSC conditions. The data collected in this study may serve as a reference database.

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  • Acute tramadol enhances brain activity associated with reward anticipation in the nucleus accumbens Reviewed

    Yuki Asari, Yumiko Ikeda, Amane Tateno, Yoshiro Okubo, Takehiko Iijima, Hidenori Suzuki

    Psychopharmacology   235 ( 9 )   1 - 12   2018.6

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    Background: Tramadol is an analgesic with monoamine reuptake inhibition and μ-opioid receptor activation. Although tramadol has been widely used for treatment of various pain conditions, there is controversy over the risk of abuse potential. We examined the effects of tramadol on the reward system in humans using functional magnetic resonance imaging (fMRI) to assess the potential of tramadol for drug abuse or dependence. Methods: A randomized, double-blind, placebo-controlled, crossover study was conducted for 19 healthy adults under tramadol or placebo. In association with subjective mood questionnaires, monetary incentive delay (MID) task was performed to assess the neural response to reward anticipation during fMRI. Subjective mood measures and blood oxygenation level-dependent (BOLD) signal during gain and loss anticipation were compared between tramadol and placebo. Results: Tramadol significantly reduced anxiety (Z = − 2.513, p = 0.012) and enhanced vigor (Z = − 2.725, p = 0.006) compared with placebo. By Mood Rating Scale, tramadol provoked contented (Z = − 2.316, p = 0.021), relaxed (Z = − 2.236, p = 0.025), and amicable feelings (Z = − 2.015, p = 0.044) as well as increased alertness (Z = − 1.972, p = 0.049) and contentedness domains (Z = − 2.174, p = 0.030) compared with placebo. Several brain regions including nucleus accumbens (NAc) were activated during gain anticipation in the MID task under both tramadol and placebo. Tramadol increased the %BOLD signal change in NAc at +\500 cue significantly more than the placebo (Z = − 2.295, p = 0.022). Conclusion: Tramadol enhances the reward system and thereby may have abuse potential or precipitate drug abuse in human.

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  • Comparison of Dopamine D3 and D2 Receptor Occupancies by a Single Dose of Blonanserin in Healthy Subjects: A Positron Emission Tomography Study With [11C]-(+)-PHNO. Reviewed

    Tateno A, Sakayori T, Kim WC, Honjo K, Nakayama H, Arakawa R, Okubo Y

    The international journal of neuropsychopharmacology   21 ( 6 )   522 - 527   2018.6

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  • Relationship of Area of Soft Drusen in Retina with Cerebral Amyloid-β Accumulation and Blood Amyloid-β Level in the Elderly Reviewed

    Chiho Shoda, Yorihisa Kitagawa, Hiroyuki Shimada, Mitsuko Yuzawa, Amane Tateno, Yoshiro Okubo

    Journal of Alzheimer's Disease   62 ( 1 )   239 - 245   2018

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    Background: Histopathological studies have confirmed that soft drusen contains amyloid-(A). Objective: To examine the relationship between the area of soft drusen in the macular area and cerebral A accumulation or plasma A level in elderly persons without dementia. Methods: Fourteen consecutive patients (18 eyes) aged ≥ 50 years with macular soft drusen were studied prospectively. From color fundus photographs, the area of soft drusen (pixel) within a 6,000 μm diameter with the macula as center was measured. Standard uptake value ratio (SUVR) was obtained from positron emission tomography using florbetapir, which indicates the ratio of cerebral cortical-to-cerebellar A accumulation. Ratio of plasma A1-42 to A1-40 level was calculated. Results: Mean age was 73.3 ± 7.6 years. The soft drusen area was 4.32 ± 2.42 mm2. The SUVR was 1.08 ± 0.15. Plasma A1-42/A1-40 ratio was 0.17 ± 0.08. When SUVR =1.10 was defined as positive and &lt
    1.10 as negative, the soft drusen area in SUVR-positive patients (6.19 ± 1.14 mm2) was significantly (p = 0.0043) larger than that in SUVR-negative patients (3.13 ± 2.27 mm2). Multivariate regression analysis showed that SUVR positivity correlated with soft drusen area (p = 0.0484) and with Voxel-based Specific Regional Analysis System for Alzheimer's Disease score (p = 0.0360). However, there was no correlation with gender (p = 0.1921), age (p = 0.2361), Alzheimer's Disease Assessment Scale score (p = 0.6310), Mini-Mental State Examination score (p = 0.4246), or plasma A1-42/A1-40 ratio (p = 0.8398). Conclusion: Among elderly persons without dementia, the area of soft drusen was larger in those with more extensive cerebral A accumulation. The area of soft drusen may be a biomarker of cerebral A accumulation.

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  • Modafinil enhances alerting-related brain activity in attention networks Reviewed

    Yumiko Ikeda, Takuya Funayama, Amane Tateno, Haruhisa Fukayama, Yoshiro Okubo, Hidenori Suzuki

    PSYCHOPHARMACOLOGY   234 ( 14 )   2077 - 2089   2017.7

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    Modafinil is a wake-promoting agent and has been reported to be effective in improving attention in patients with attentional disturbance. However, neural substrates underlying the modafinil effects on attention are not fully understood.
    We employed a functional magnetic resonance imaging (fMRI) study with the attention network test (ANT) task in healthy adults and examined which networks of attention are mainly affected by modafinil and which neural substrates are responsible for the drug effects.
    We used a randomized placebo-controlled within-subjects cross-over design. Twenty-three healthy adults participated in two series of an fMRI study, taking either a placebo or modafinil. The participants performed the ANT task, which is designed to measure three distinct attentional networks, alerting, orienting, and executive control, during the fMRI scanning. The effects of modafinil on behavioral performance and regional brain activity were analyzed.
    We found that modafinil enhanced alerting performance and showed greater alerting network activity in the left middle and inferior occipital gyri as compared with the placebo. The brain activations in the occipital regions were positively correlated with alerting performance.
    Modafinil enhanced alerting performance and increased activation in the occipital lobe in the alerting network possibly relevant to noradrenergic activity during the ANT task. The present study may provide a rationale for the treatment of patients with distinct symptoms of impaired attention.

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  • Effect of apolipoprotein E phenotype on the association of plasma amyloid β and amyloid positron emission tomography imaging in Japan Reviewed

    Amane Tateno, Takeshi Sakayori, Woo Chan Kim, Michihiko Koeda, Shinichiro Kumita, Hidenori Suzuki, Yoshiro Okubo

    Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring   9   51 - 56   2017

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    Introduction The plasma concentration of beta-amyloid (Aβ) has been considered another biomarker of Alzheimer's disease and was reportedly associated with cortical Aβ accumulation. Methods We analyzed 28 subjects with apolipoprotein E4 (ApoE4
    E4 group) and 89 subjects without ApoE4 (non-E4 group) to determine the association between cortical Aβ accumulation by standard uptake value ratio with [18F]florbetapir positron emission tomography and plasma Aβ1–40 and Aβ1–42. Results Aβ1–42/Aβ1–40 correlated significantly with mean regional [18F]florbetapir standard uptake value ratio in the non-E4 group (R2 = 0.06, P =.02) but not in the E4 group, and receiver operating characteristic curve analysis for Aβ1–42/Aβ1–40 in the non-E4 group showed sensitivity (92.9%) and specificity (45.9%) with a cutoff value of 0.150 for Aβ positivity. Discussion We verified that the correlation between Aβ1–42/Aβ1–40 and Aβ accumulation differed according to ApoE phenotype. The high sensitivity of plasma Aβ1–42/Aβ1–40 for Aβ positivity in non-E4 subjects indicated a possible role of plasma Aβ1–42/Aβ1–40 as a screening biomarker before amyloid positron emission tomography in clinical settings.

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  • Effect of placebo and lorazepam on functional connectivity in fearful vocal processing: an fMRI study Reviewed

    Michihiko Koeda, Takeshi Hase, Tomoko Hama, Yumiko Ikeda, Noriaki Yahata, Amane Tateno, Hidehiko Takahashi, Masato Matsuura, Hidenori Suzuki, Yoshiro Okubo

    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY   19   54 - 54   2016.6

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  • Time-course of serotonin transporter occupancy by single dose of three SSRIs in human brain: A positron emission tomography study with [C-11]DASB Reviewed

    Ryosuke Arakawa, Amane Tateno, WooChan Kim, Takeshi Sakayori, Kohei Ogawa, Yoshiro Okubo

    PSYCHIATRY RESEARCH-NEUROIMAGING   251   1 - 6   2016.5

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    Sixteen healthy volunteers were enrolled and divided into four groups according to the single administration of 10 mg or 20 mg escitalopram, 50 mg sertraline, or 20 mg paroxetine. Four positron emission tomography scans with [C-11]DASB were performed on each subject, the first prior to taking the drug, followed by the others at 4, 24, and 48 h after. Serotonin transporter occupancies of the drugs at each time point were calculated. All drugs showed maximum occupancy at 4 h after dosing and then decreasing occupancies with time. Escitalopram and sertraline showed high occupancies of 69.1-77.9% at 4 h, remaining at 52.8-57.8% after 48 h. On the other hand, paroxetine showed relatively low occupancy of 44.6%, then decreasing to 10.3% at 48 h. Escitalopram (both 10 mg and 20 mg) and sertraline (50 mg) showed high and sustained occupancy. Paroxetine (20 mg) showed relatively low and rapidly decreasing occupancy, possibly due to the low plasma concentration by single dosing schedule. Applying the reported concentration of multiple dosing, 20 mg paroxetine will induce over 80% occupancy. The present study suggested that these drugs and doses would be sufficient for the treatment of depression. (C) 2016 Published by Elsevier Ireland Ltd.

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  • Amyloid imaging with [F-18]florbetapir in geriatric depression: early-onset versus late-onset Reviewed

    Amane Tateno, Takeshi Sakayori, Makoto Higuchi, Tetsuya Suhara, Keiichi Ishihara, Shinichiro Kumita, Hidenori Suzuki, Yoshiro Okubo

    INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY   30 ( 7 )   720 - 728   2015.7

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    BackgroundWe examined patients with mild cognitive impairment (MCI) with a history of geriatric depression (GD) and healthy controls (HC) to evaluate the effect of beta-amyloid (A) pathology on the pathology of GD by using [F-18]florbetapir PET.
    MethodsThirty-three elderly patients (76.74.2years) and 22 healthy controls (HC; 72.04.5years, average +/- SD) were examined by [F-18]florbetapir positron emission tomography (PET) to quantify the standard uptake value ratio (SUVR) as the degree of amyloid accumulation, by MRI to determine the degree of atrophy, by Mini-Mental State Examination for cognitive functions, and by Geriatric Depression Scale for the severity of depression, and by Clinical Dementia Rating for activity of daily living (ADL). The cut-off value of 1.08 for SUVR was defined as A-positive.
    ResultsOf the patients and HC, 39.4% and 27.3%, respectively, were beta-amyloid-positive. The onset age of GD was significantly correlated with SUVR (r=0.44, p&lt;0.01). Compared to patients without A (GD-A), patients with A (GD+A) did not differ in terms of age, cognitive function, severity of depression and ADL, and brain atrophy. GD+A had significantly older average +/- SD age at onset of GD (73.6 +/- 7.1 versus 58.7 +/- 17.8, p&lt;0.01) and significantly shorter average +/- SD time between onset of GD and PET scan day (3.1 +/- 5.2years versus 18.1 +/- 18.6years, p&lt;0.001) than GD-A.
    ConclusionsOur results showed that the rate of A positivity was higher in late-onset GD and that onset-age was associated with SUVR, suggesting that the later the onset of GD, the more A pathology affected its onset. Copyright (c) 2014 John Wiley & Sons, Ltd.

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  • Comparison of imaging biomarkers for Alzheimer's disease: amyloid imaging with [F-18]florbetapir positron emission tomography and magnetic resonance imaging voxel-based analysis for entorhinal cortex atrophy Reviewed

    Amane Tateno, Takeshi Sakayori, Yoshitaka Kawashima, Makoto Higuchi, Tetsuya Suhara, Sunao Mizumura, Mark A. Mintun, Daniel M. Skovronsky, Kazuyoshi Honjo, Keiichi Ishihara, Shinichiro Kumita, Hidenori Suzuki, Yoshiro Okubo

    INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY   30 ( 5 )   505 - 513   2015.5

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    ObjectiveWe compared amyloid positron emission tomography (PET) and magnetic resonance imaging (MRI) in subjects clinically diagnosed with Alzheimer's disease (AD), mild cognitive impairment (MCI), and older healthy controls (OHC) in order to test how these imaging biomarkers represent cognitive decline in AD.
    MethodsFifteen OHC, 19 patients with MCI, and 19 patients with AD were examined by [F-18]florbetapir PET to quantify the standard uptake value ratio (SUVR) as the degree of amyloid accumulation, by MRI and the voxel-based specific regional analysis system for AD to calculate z-score as the degree of entorhinal cortex atrophy, and by mini-mental state examination (MMSE) and Alzheimer's Disease Assessment Scale-cognitive componentJapanese version (ADAS-Jcog) for cognitive functions.
    ResultsBoth cutoff values for measuring AD-like levels of amyloid (1.099 for SUVR) and entorhinal cortex atrophy (1.60 for z-score) were well differentially diagnosed and clinically defined AD from OHC (84.2% for SUVR and 86.7% for z-score). Subgroup analysis based on beta-amyloid positivity revealed that z-score significantly correlated with MMSE (r=-0.626, p&lt;0.01) and ADAS-Jcog (r=0.691, p&lt;0.01) only among subjects with beta-amyloid.
    ConclusionsThis is the first study to compare [F-18]florbetapir PET and MRI voxel-based analysis of entorhinal cortex atrophy for AD. Both [F-18]florbetapir PET and MRI detected changes in AD compared with OHC. Considering that entorhinal cortex atrophy correlated well with cognitive decline only among subjects with beta-amyloid, [F-18]florbetapir PET makes it possible to detect AD pathology in the early stage, whereas MRI morphometry for subjects with beta-amyloid provides a good biomarker to assess the severity of AD in the later stage. Copyright (c) 2014 John Wiley & Sons, Ltd.

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  • Interaction effect between handedness and CNTNAP2 polymorphism (rs7794745 genotype) on voice-specific frontotemporal activity in healthy individuals: an fMRI study Reviewed

    Michihiko Koeda, Atsushi Watanabe, Kumiko Tsuda, Miwako Matsumoto, Yumiko Ikeda, Woochan Kim, Amane Tateno, Banyar Than Naing, Hiroyuki Karibe, Takashi Shimada, Hidenori Suzuki, Masato Matsuura, Yoshiro Okubo

    FRONTIERS IN BEHAVIORAL NEUROSCIENCE   9   87   2015.4

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    Recent neuroimaging studies have demonstrated that Contactin-associated protein-like2 (CNTNAP2) polymorphisms affect left-hemispheric function of language processing in healthy individuals, but no study has investigated the influence of these polymorphisms on right-hemispheric function involved in human voice perception. Further, although recent reports suggest that determination of handedness is influenced by genetic effect, the interaction effect between handedness and CNTNAP2 polymorphisms for brain activity in human voice perception and language processing has not been revealed. We aimed to investigate the interaction effect of handedness and CNTNAP2 polymorphisms in respect to brain function for human voice perception and language processing in healthy individuals. Brain function of 108 healthy volunteers (74 right-handed and 34 non-right-handed) was examined while they were passively listening to reverse sentences (rSEN), identifiable non-vocal sounds (SND), and sentences (SEN). Full factorial design analysis was calculated by using three factors: (1) rs7794745 (A/A or A/T), (2) rs2710102 [G/G or A carrier (A/G and A/A)], and (3) voice-specific response (rSEN or SND). The main effect of rs7794745 (A/A or A/T) was significantly revealed at the right middle frontal gyrus (MFG) and bilateral superior temporal gyrus (STG). This result suggests that rs7794745 genotype affects voice-specific brain function. Furthermore, interaction effect was significantly observed among MFG-STG activations by human voice perception, rs7794745 (A/A or A/T), and handedness. These results suggest that CNTNAP2 polymorphisms could be one of the important factors in the neural development related to vocal communication and language processing in both right-handed and non-right-handed healthy individuals.

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  • A case of Alzheimer's disease following mild traumatic brain injury Reviewed

    Amane Tateno, Takeshi Sakayori, Yuichi Takizawa, Ken Yamamoto, Kaoru Minagawa, Yoshiro Okubo

    GENERAL HOSPITAL PSYCHIATRY   37 ( 1 )   97.e7 - 9   2015.1

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    Objective: To report a case of Alzheimer's disease (AD) following mild traumatic brain injury (TBI).
    Method: Case report.
    Results: We report the time course of AD following mild TBI with evidence of AD pathology. A patient complained of minor memory disturbance 6 months after TBI and was diagnosed with mild cognitive impairment 1.5 years after TBI, and she was finally diagnosed as probable AD 4 years after TBI. Amyloid PET revealed brain accumulation of beta-amyloid at a pathological AD level.
    Conclusion: Our case well illustrated how TBI can accelerate the AD process. Clinicians should carefully follow up patients with persistent cognitive impairment after TBI. (C) 2015 Elsevier Inc. All rights reserved.

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  • Modafinil augments brain activation associated with reward anticipation in the nucleus accumbens Reviewed

    Takuya Funayama, Yumiko Ikeda, Amane Tateno, Hidehiko Takahashi, Yoshiro Okubo, Haruhisa Fukayama, Hidenori Suzuki

    PSYCHOPHARMACOLOGY   231 ( 16 )   3217 - 3228   2014.8

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    The nucleus accumbens (NAc) works as a key brain structure of the reward system, in which reward-related neural activity is well correlated with dopamine release from mesolimbic dopaminergic neurons.
    Since modafinil can modulate dopaminergic transmission through re-uptake inhibition of dopamine, we investigated whether modafinil affects the reward-related brain activity in the NAc in healthy subjects.
    Twenty healthy participants underwent two series of functional magnetic resonance imaging while performing monetary incentive delay task in which they were cued to anticipate and respond to a rapidly presented target to gain or avoid losing varying amounts of money, under modafinil or placebo condition. Blood oxygenation-level dependent (BOLD) activation signals during gain and loss anticipations were analyzed in the NAc as an a priori region of interest as well as the whole brain.
    Modafinil significantly changed subjective feelings toward positive ones. The activation of BOLD signals was observed during gain anticipation under the placebo and modafinil conditions in the left and bilateral NAc, respectively. The modafinil condition showed significantly higher BOLD signal change at the highest gain (+Ayen500) cue compared to the placebo condition.
    The present study showed that modafinil affects reward processing in the NAc in healthy subjects through enhancing more positive anticipation, and it may provide a basis for the use of this drug for treating anhedonia observed in psychiatric disorders.

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  • Effect of mazindol on extracellular dopamine concentration in human brain measured by PET Reviewed

    Takeshi Sakayori, Amane Tateno, Ryosuke Arakawa, Yumiko Ikeda, Hidenori Suzuki, Yoshiro Okubo

    PSYCHOPHARMACOLOGY   231 ( 11 )   2321 - 2325   2014.6

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    Mazindol, an appetite suppressant, inhibits the reuptake of dopamine in the synaptic cleft. It has been considered that mazindol might enhance dopamine transmission in the human brain. However, there has been no study that investigated the extracellular dopamine concentration in vivo.
    Using positron emission tomography (PET), we aimed to measure the effect of mazindol on the extracellular dopamine concentration and to evaluate how mazindol affects the dopamine system in the healthy human brain.
    Eleven healthy individuals (six males, five females, age 30.9 +/- 4.9 years) were enrolled in this study. Each participant was scanned with [C-11]raclopride on 1 day without any medicine as baseline condition, and on another day with mazindol as drug condition. In the drug condition, participants took mazindol 0.5 mg (N = 5) or 1.5 mg (N = 6) 2 h before the PET scan. Plasma concentrations of mazindol were measured before the injection of [C-11]raclopride, and urine concentrations of mazindol were measured after the scan.
    After taking mazindol, the calculated decrease in binding potential (Delta BP) in the striatum was 1.74 % for 0.5 mg and 8.14 for 1.5 mg, and the correlation with the blood concentration of mazindol was significant (P = 0.0016, R (2) = 0.69). Delta BP was not significantly correlated with the urine concentration of mazindol (P = 0.84, R (2) = 0.005).
    Mazindol increased the extracellular concentration of dopamine in the human brain, and its effect was dose dependent. A single administration of mazindol, even at usual dosage, elevated dopamine concentration similarly to other addictive drugs, suggesting that the risk of dependence may increase with the mazindol dose.

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  • Occupancy of serotonin transporter by tramadol: a positron emission tomography study with [C-11] DASB Reviewed

    Kohei Ogawa, Amane Tateno, Ryosuke Arakawa, Takeshi Sakayori, Yumiko Ikeda, Hidenori Suzuki, Yoshiro Okubo

    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY   17 ( 6 )   845 - 850   2014.6

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    Tramadol is used for the treatment of pain, and it is generally believed to activate the -opioid receptor and inhibit serotonin (5-HT) and norepinephrine (NE) transporters. Recent findings from animal experiments suggest that 5-HT reuptake inhibition in brain is related to pain reduction. However, there has been no report of 5-HT transporter (5-HTT) occupancy by tramadol at clinical doses in humans. In the present study, we investigated 5-HTT occupancy by tramadol in five subjects receiving various doses of tramadol by using positron emission tomography (PET) scanning with the radioligand [C-11]DASB. Our data showed that mean 5-HTT occupancies in the thalamus by single doses of tramadol were 34.7% at 50mg and 50.2% at 100mg. The estimated median effective dose (ED50) of tramadol was 98.1mg, and the plasma concentration was 0.33g/ml 2h after its administration; 5-HTT occupancy by tramadol was dose-dependent. We estimated 5-HTT occupancy at 78.7% upon taking an upper limit dose (400mg) of tramadol. The results of the present study support the finding that 5-HTT inhibition is involved in the mechanism underlying the analgesic effect of tramadol in humans, and a clinical dose of tramadol sufficiently inhibits 5-HTT reuptake; this inhibition is similar to that shown by selective serotonin reuptake inhibitors (SSRIs).

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  • Amyloid plaque among patients with mild cognitive impairment following traumatic brain injury detected by [18F]florbetapir Reviewed

    Amane Tateno, Takeshi Sakayori, Akira Senzaki, Yoshiro Okubo

    BRAIN INJURY   28 ( 5-6 )   742 - 743   2014.5

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  • In vivo activity of modafinil on dopamine transporter measured with positron emission tomography and [F-18]FE-PE2I Reviewed

    WooChan Kim, Amane Tateno, Ryosuke Arakawa, Takeshi Sakayori, Yumiko Ikeda, Hidenori Suzuki, Yoshiro Okubo

    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY   17 ( 5 )   697 - 703   2014.5

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    Modafinil, a wake-promoting drug used to treat narcolepsy, is a dopamine transporter inhibitor and is said to have very low abuse liability; this, however, is still up for debate. We conducted a dopamine transporter (DAT) occupancy study with modafinil (200 or 300mg) in ten healthy volunteers using positron emission tomography (PET) with [F-18]FE-PE2I, a new PET radioligand with high affinity and selectivity for the dopamine transporter, to characterize its relation to abuse liability. Mean striatal DAT occupancies were 51.4% at 200mg and 56.9% at 300mg. There was a significant correlation between occupancy and plasma concentration, indicating dose dependency of DAT inhibition by modafinil in the striatum, and especially in the nucleus accumbens. This study showed that DAT occupancy by modafinil was close to that of methylphenidate, indicating that modafinil may be near the same level as methylphenidate in relation to abuse liability in terms of dopaminergic transmission.

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  • Age-related decline in dopamine transporter in human brain using PET with a new radioligand [F-18]FE-PE2I Reviewed

    Yoshitoshi Shingai, Amane Tateno, Ryosuke Arakawa, Takeshi Sakayori, WooChan Kim, Hidenori Suzuki, Yoshiro Okubo

    ANNALS OF NUCLEAR MEDICINE   28 ( 3 )   220 - 226   2014.4

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    Dopamine transporter (DAT) density is considered as a marker of pre-synaptic function. Numerous neuroimaging studies have consistently demonstrated an age-related decrease in DAT density in normal human brain. However, the precise degree of the regional decline is not yet clear. The purpose of this study was to evaluate the effect of the normal aging process on DAT densities in human-specific brain regions including the substantia nigra and thalamus using positron emission tomography (PET) with [F-18]FE-PE2I, a new PET radioligand with high affinity and selectivity for DAT.
    Thirty-six healthy volunteers ranging in age from 22 to 80 years were scanned with PET employing [F-18]FE-PE2I for measuring DAT densities. Region of interest (ROI)-based analysis was used, and ROIs were manually defined for the caudate, putamen, substantia nigra, thalamus, and cerebellar cortex. DAT binding was quantified using a simplified reference tissue model, and the cerebellum was used as reference region. Estimations of binding potential in the caudate, putamen, substantia nigra, and thalamus were individually regressed according to age using simple regression analysis. Estimates of DAT loss per decade were obtained using the values from the regression slopes.
    There were 7.6, 7.7, and 3.4 % per-decade declines in DAT in the caudate, putamen, and substantia nigra, respectively. By contrast, there was no age-related decline of DAT in the thalamus.
    [F-18]FE-PE2I allowed reliable quantification of DAT, not only in the caudate and putamen but also in the substantia nigra. From the results, we demonstrated the age-related decline in the caudate and putamen as reported in previous studies, and additionally for those in the substantia nigra for the first time.

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  • Norepinephrine transporter occupancy by nortriptyline in patients with depression: a positron emission tomography study with (S,S)-[¹⁸F]FMeNER-D₂. International journal

    Harumasa Takano, Ryosuke Arakawa, Tsuyoshi Nogami, Masayuki Suzuki, Tomohisa Nagashima, Hironobu Fujiwara, Yasuyuki Kimura, Fumitoshi Kodaka, Keisuke Takahata, Hitoshi Shimada, Yoshitaka Murakami, Amane Tateno, Makiko Yamada, Hiroshi Ito, Kazunori Kawamura, Ming-Rong Zhang, Hidehiko Takahashi, Motoichiro Kato, Yoshiro Okubo, Tetsuya Suhara

    The international journal of neuropsychopharmacology   17 ( 4 )   553 - 60   2014.4

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    Norepinephrine transporter (NET) plays important roles in the treatment of various neuropsychiatric disorders, such as depression and attention deficit hyperactivity disorder (ADHD). Nortriptyline is a NET-selective tricyclic antidepressant (TCAs) that has been widely used for the treatment of depression. Previous positron emission tomography (PET) studies have reported over 80% serotonin transporter occupancy with clinical doses of selective serotonin reuptake inhibitors (SSRIs), but there has been no report of NET occupancy in patients treated with relatively NET-selective antidepressants. In the present study, we used PET and (S,S)-[18¹⁸F]FMeNER-D₂ to investigate NET occupancies in the thalamus in 10 patients with major depressive disorder taking various doses of nortriptyline, who were considered to be responders to the treatment. Reference data for the calculation of occupancy were derived from age-matched healthy controls. The result showed approximately 50-70% NET occupancies in the brain as a result of the administration of 75-200 mg/d of nortriptyline. The estimated effective dose (ED₅₀) and concentration (EC₅₀) required to induce 50% occupancy was 65.9 mg/d and 79.8 ng/ml, respectively. Furthermore, as the minimum therapeutic level of plasma nortriptyline for the treatment of depression has been reported to be 70 ng/ml, our data indicate that this plasma nortriptyline concentration corresponds to approximately 50% NET occupancy measured with PET, suggesting that more than 50% of central NET occupancy would be appropriate for the nortriptyline treatment of patients with depression.

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  • Norepinephrine transporter occupancy by nortriptyline in patients with depression: a positron emission tomography study with (S,S)-[F-18]FMeNER-D-2 Reviewed

    Harumasa Takano, Ryosuke Arakawa, Tsuyoshi Nogami, Masayuki Suzuki, Tomohisa Nagashima, Hironobu Fujiwara, Yasuyuki Kimura, Fumitoshi Kodaka, Keisuke Takahata, Hitoshi Shimada, Yoshitaka Murakami, Amane Tateno, Makiko Yamada, Hiroshi Ito, Kazunori Kawamura, Ming-Rong Zhang, Hidehiko Takahashi, Motoichiro Kato, Yoshiro Okubo, Tetsuya Suhara

    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY   17 ( 4 )   553 - 560   2014.4

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    Norepinephrine transporter (NET) plays important roles in the treatment of various neuropsychiatric disorders, such as depression and attention deficit hyperactivity disorder (ADHD). Nortriptyline is a NET-selective tricyclic antidepressant (TCAs) that has been widely used for the treatment of depression. Previous positron emission tomography (PET) studies have reported over 80% serotonin transporter occupancy with clinical doses of selective serotonin reuptake inhibitors (SSRIs), but there has been no report of NET occupancy in patients treated with relatively NET-selective antidepressants. In the present study, we used PET and (S,S)-[F-18]FMeNER-D-2 to investigate NET occupancies in the thalamus in 10 patients with major depressive disorder taking various doses of nortriptyline, who were considered to be responders to the treatment. Reference data for the calculation of occupancy were derived from age-matched healthy controls. The result showed approximately 50-70% NET occupancies in the brain as a result of the administration of 75-200mg/d of nortriptyline. The estimated effective dose (ED50) and concentration (EC50) required to induce 50% occupancy was 65.9mg/d and 79.8ng/ml, respectively. Furthermore, as the minimum therapeutic level of plasma nortriptyline for the treatment of depression has been reported to be 70ng/ml, our data indicate that this plasma nortriptyline concentration corresponds to approximately 50% NET occupancy measured with PET, suggesting that more than 50% of central NET occupancy would be appropriate for the nortriptyline treatment of patients with depression.

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  • Amyloid Positron Emission Tomography Imaging for the Differential Diagnosis of Alzheimer's Disease Reviewed

    Amane Tateno, Takeshi Sakayori, Yoshiro Okubo

    JOURNAL OF NIPPON MEDICAL SCHOOL   81 ( 1 )   2 - 3   2014.2

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  • Efficacy and Tolerability of Risperidone, Yokukansan, and Fluvoxamine for the Treatment of Behavioral and Psychological Symptoms of Dementia A Blinded, Randomized Trial Reviewed

    Mika Teranishi, Masatake Kurita, Satoshi Nishino, Kenji Takeyoshi, Yukio Numata, Tadahiro Sato, Amane Tateno, Yoshiro Okubo

    JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY   33 ( 5 )   600 - 607   2013.10

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    The descriptive term behavioral and psychological symptoms of dementia (BPSD) is used to cover a range of noncognitive disturbances including anxiety, depression, irritability, aggression, agitation, eating disorders, and inappropriate social or sexual behaviors. Behavioral and psychological symptoms of dementia are seen in about 90% of patients with dementia. We aimed to compare the efficacy and tolerability of risperidone, yokukansan, and fluvoxamine used for BPSD in elderly patients with dementia. Ninety inpatients with dementia according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition criteria were investigated in Sato Hospital, Koutokukai. We conducted an 8-week, rater-blinded, randomized trial, administering flexibly dosed risperidone, yokukansan, or fluvoxamine. Primary outcome measures were Neuropsychiatric Inventory in Nursing Home Version total score and its items. Secondary outcome measures were cognitive function measured by Mini-Mental State Examination and daily life function measured by Functional Independence Measure (FIM). Neurological adverse effects were measured by the Drug-Induced Extra-Pyramidal Symptoms Scale. At the end of the study, we analyzed 76 patients (92.7%). Mean Neuropsychiatric Inventory in Nursing Home Version total score decreased in all 3 drug groups, with no significant between-group differences. Mini-Mental State Examination and Functional Independence Measure scores did not change significantly. Drug-Induced Extra-Pyramidal Symptoms Scale scores did not change in the yokukansan and fluvoxamine groups, but increased significantly in the risperidone group. Risperidone, yokukansan, and fluvoxamine were equally effective in the treatment of BPSD in elderly patients. However, yokukansan or fluvoxamine for BPSD showed a more favorable profile in tolerability compared with risperidone. This trial is registered at UMIN Clinical Trials Registry (identifier: UMIN000006146).

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  • Acute NK1 receptor antagonist administration affects reward incentive anticipation processing in healthy volunteers Reviewed

    Kanako Saji, Yumiko Ikeda, Woochan Kim, Yoshitoshi Shingai, Amane Tateno, Hidehiko Takahashi, Yoshiro Okubo, Haruhisa Fukayama, Hidenori Suzuki

    International Journal of Neuropsychopharmacology   16 ( 7 )   1461 - 1471   2013.8

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    The primary brain structures of reward processing are mainly situated in the mid-brain dopamine system. The nucleus accumbens (NAc) receives dopaminergic projections from the ventral tegmental area and works as a key brain region for the positive incentive value of rewards. Because neurokinin-1 (NK1) receptor, the cognate receptor for substance P (SP), is highly expressed in the NAc, we hypothesized that the SP/NK1 receptor system might play a role in positive reward processing in the NAc in humans. Therefore, we conducted a functional MRI (fMRI) study to assess the effects of an NK1 receptor antagonist on human reward processing through a monetary incentive delay task that is known to elicit robust activation in the NAc especially during gain anticipation. Eighteen healthy adults participated in two series of an fMRI study, taking either a placebo or the NK1 receptor antagonist aprepitant. Behavioural measurements revealed that there was no significant difference in reaction time, hit rate, or self-reported effort for incentive cues between the placebo and aprepitant treatments. fMRI showed significant decrease in blood oxygenation-level-dependent signals in the NAc during gain anticipation with the aprepitant treatment compared to the placebo treatment. These results suggest that SP/NK1 receptor system is involved in processing of positive incentive anticipation and plays a role in accentuating positive valence in association with the primary dopaminergic pathways in the reward circuit. © CINP 2013.

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  • Occupancy of serotonin and norepinephrine transporter by milnacipran in patients with major depressive disorder: a positron emission tomography study with [C-11]DASB and (S,S)-[F-18]FMeNER-D-2 Reviewed

    Tsuyoshi Nogami, Harumasa Takano, Ryosuke Arakawa, Tetsuya Ichimiya, Hironobu Fujiwara, Yasuyuki Kimura, Fumitoshi Kodaka, Takeshi Sasaki, Keisuke Takahata, Masayuki Suzuki, Tomohisa Nagashima, Takaaki Mori, Hitoshi Shimada, Hajime Fukuda, Mizuho Sekine, Amane Tateno, Hidehiko Takahashi, Hiroshi Ito, Yoshiro Okubo, Tetsuya Suhara

    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY   16 ( 5 )   937 - 943   2013.6

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    Antidepressants used for treatment of depression exert their efficacy by blocking reuptake at serotonin transporters (5-HTT) and/or norepinephrine transporters (NET). Recent studies suggest that serotonin and norepinephrine reuptake inhibitors that block both 5-HTT and NET have better tolerability than tricyclic antidepressants and may have higher efficacy compared to selective serotonin reuptake inhibitors. Previous positron emission tomography (PET) studies have reported &gt;80% 5-HTT occupancy with clinical doses of antidepressants, but there has been no report of NET occupancy in patients treated with antidepressants. In the present study, we investigated both 5-HTT and NET occupancies by PET using radioligands [C-11]DASB and (S,S)-[F-18]FMeNER-D-2, in six patients, each with major depressive disorder (MDD), using various doses of milnacipran. Our data show that mean 5-HTT occupancy in the thalamus was 33.0% at 50 mg, 38.6% at 100 mg, 60.0% at 150 mg and 61.5% at 200 mg. Mean NET occupancy in the thalamus was 25.3% at 25 mg, 40.0% at 100 mg, 47.3% at 125 mg and 49.9% at 200 mg. Estimated ED50 was 122.5 mg with the dose for 5-HTT and 149.9 mg for NET. Both 5-HTT and NET occupancies were observed in a dose-dependent manner. Both 5-HTT and NET occupancies were about 40% by milnacipran at 100 mg, the dose most commonly administered to MDD patients.

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  • Occupancy of serotonin and norepinephrine transporter by milnacipran in patients with major depressive disorder: a positron emission tomography study with [(11)C]DASB and (S,S)-[(18)F]FMeNER-D(2). International journal

    Tsuyoshi Nogami, Harumasa Takano, Ryosuke Arakawa, Tetsuya Ichimiya, Hironobu Fujiwara, Yasuyuki Kimura, Fumitoshi Kodaka, Takeshi Sasaki, Keisuke Takahata, Masayuki Suzuki, Tomohisa Nagashima, Takaaki Mori, Hitoshi Shimada, Hajime Fukuda, Mizuho Sekine, Amane Tateno, Hidehiko Takahashi, Hiroshi Ito, Yoshiro Okubo, Tetsuya Suhara

    The international journal of neuropsychopharmacology   16 ( 5 )   937 - 43   2013.6

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    Antidepressants used for treatment of depression exert their efficacy by blocking reuptake at serotonin transporters (5-HTT) and/or norepinephrine transporters (NET). Recent studies suggest that serotonin and norepinephrine reuptake inhibitors that block both 5-HTT and NET have better tolerability than tricyclic antidepressants and may have higher efficacy compared to selective serotonin reuptake inhibitors. Previous positron emission tomography (PET) studies have reported >80% 5-HTT occupancy with clinical doses of antidepressants, but there has been no report of NET occupancy in patients treated with antidepressants. In the present study, we investigated both 5-HTT and NET occupancies by PET using radioligands [(11)C]DASB and (S,S)-[(18)F]FMeNER-D(2), in six patients, each with major depressive disorder (MDD), using various doses of milnacipran. Our data show that mean 5-HTT occupancy in the thalamus was 33.0% at 50 mg, 38.6% at 100 mg, 60.0% at 150 mg and 61.5% at 200 mg. Mean NET occupancy in the thalamus was 25.3% at 25 mg, 40.0% at 100 mg, 47.3% at 125 mg and 49.9% at 200 mg. Estimated ED(50) was 122.5 mg with the dose for 5-HTT and 149.9 mg for NET. Both 5-HTT and NET occupancies were observed in a dose-dependent manner. Both 5-HTT and NET occupancies were about 40% by milnacipran at 100 mg, the dose most commonly administered to MDD patients.

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  • Striatal and Extrastriatal Dopamine D-2 Receptor Occupancy by a Novel Antipsychotic, Blonanserin A PET Study With [C-11]Radopride and [C-11]FLB 457 in Schizophrenia Reviewed

    Amane Tateno, Ryosuke Arakawa, Masaki Okumura, Hajime Fukuta, Kazuyoshi Honjo, Keiichi Ishihara, Hiroshi Nakamura, Shin-ichiro Kumita, Yoshiro Okubo

    JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY   33 ( 2 )   162 - 169   2013.4

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    Blonanserin is a novel antipsychotic with high affinities for dopamine D-2 and 5-HT2A receptors, and it was recently approved for the treatment of schizophrenia in Japan and Korea. Although double-blind clinical trials have demonstrated that blonanserin has equal efficacy to risperidone, and with a better profile especially with respect to prolactin elevation, its profile of in vivo receptor binding has not been investigated in patients with schizophrenia. Using positron emission tomography (PET), we measured striatal and extrastriatal dopamine D-2 receptor occupancy by blonanserin in 15 patients with schizophrenia treated with fixed doses of blonanserin (ie, 8, 16, and 24 mg/d) for at least 4 weeks before PET scans, and in 15 healthy volunteers. Two PET scans, 1 with [C-11]raclopride for the striatum and 1 with [C-11]FLB 457 for the temporal cortex and pituitary, were performed on the same day. Striatal dopamine D2 receptor occupancy by blonanserin was 60.8% (3.0%) [mean (SD)] at 8 mg, 73.4% (4.9%) at 16 mg, and 79.7% (2.3%) at 24 mg. The brain/plasma concentration ratio calculated from D-2 receptor occupancy in the temporal cortex and pituitary was 3.38, indicating good blood-brain barrier permeability. This was the first study to show clinical daily dose amounts of blonanserin occupying dopamine D-2 receptors in patients with schizophrenia. The clinical implications obtained in this study were the optimal therapeutic dose range of 12.9 to 22.1 mg/d of blonanserin required for 70% to 80% dopamine D-2 receptor occupancy in the striatum, and the good blood-brain barrier permeability that suggested a relatively lower risk of hyperprolactinemia.

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  • Effects of menopause on brain structural changes in schizophrenia

    Hajime Fukuta, Itsuo Ito, Amane Tateno, Tsuyoshi Nogami, Yasutomo Taiji, Ryosuke Arakawa, Tetsuya Suhara, Kunihiko Asai, Yoshiro Okubo

    Psychiatry and Clinical Neurosciences   67 ( 1 )   3 - 11   2013.1

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    Aim The aim of this study was to investigate the influences of menopause on brain morphological changes in schizophrenia using magnetic resonance imaging (MRI). Methods Forty female schizophrenia patients, 20 premenopausal and 20 postmenopausal, and 50 female controls underwent cerebral MRI. Optimized voxel-based morphometry was performed with Statistical Parametric Mapping version 5. Results Compared with controls, regional gray matter reductions in schizophrenia patients were observed in the insula, superior temporal gyrus, anterior cingulate, parahippocampal gyrus, and thalamus. Direct comparison between the patient groups showed that the gray matter of postmenopausal patients was significantly smaller when compared with premenopausal patients in the left middle frontal gyrus, and no region had significantly lower gray matter volume in premenopausal patients relative to postmenopausal patients. Significant negative correlation between gray matter volume and the interval after menopause was found in the right superior frontal gyrus in the postmenopause patient group. Conclusion Differential morphological alterations between postmenopausal and premenopausal schizophrenia patients were observed, suggesting that the female hormone plays a protective role against schizophrenia. © 2013 The Authors. Psychiatry and Clinical Neurosciences © 2013 Japanese Society of Psychiatry and Neurology.

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  • [Effect of menopause on morphological changes of the brain in schizophrenia]. Reviewed

    Fukuta H, Ito I, Tateno A, Nogami T, Taiji Y, Arakawa R, Suhara T, Asai K, Okubo Y

    Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica   115 ( 12 )   1178 - 1185   2013

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  • Influence of contact with schizophrenia on implicit attitudes towards schizophrenia patients held by clinical residents Reviewed

    Ataru Omori, Amane Tateno, Takashi Ideno, Hidehiko Takahashi, Yoshitaka Kawashima, Kazuhisa Takemura, Yoshiro Okubo

    BMC PSYCHIATRY   12   205   2012.11

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    Background: Patients with schizophrenia and their families have suffered greatly from stigmatizing effects. Although many efforts have been made to eradicate both prejudice and stigma, they still prevail even among medical professionals, and little is known about how contact with schizophrenia patients affects their attitudes towards schizophrenia.
    Methods: We assessed the impact of the renaming of the Japanese term for schizophrenia on clinical residents and also evaluated the influence of contact with schizophrenia patients on attitudes toward schizophrenia by comparing the attitudes toward schizophrenia before and after a one-month clinical training period in psychiatry. Fifty-one clinical residents participated. Their attitudes toward schizophrenia were assessed twice, before and one month after clinical training in psychiatry using the Implicit Association Test (IAT) as well as Link's devaluation-discrimination scale.
    Results: The old term for schizophrenia, "Seishin-Bunretsu-Byo", was more congruent with criminal than the new term for schizophrenia, "Togo-Shitcho-Sho", before clinical training. However, quite opposite to our expectation, after clinical training the new term had become even more congruent with criminal than the old term. There was no significant correlation between Link's scale and IAT effect.
    Conclusions: Renaming the Japanese term for schizophrenia still reduced the negative images of schizophrenia among clinical residents. However, contact with schizophrenia patients unexpectedly changed clinical residents' attitudes towards schizophrenia negatively. Our results might contribute to an understanding of the formation of negative attitudes about schizophrenia and assist in developing appropriate clinical training in psychiatry that could reduce prejudice and stigma concerning schizophrenia.

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  • Caffeine's Effects on Attentional Networks in Healthy Subjects: A Pharmacological Functional Magnetic Resonance Imaging Study Reviewed

    Yumiko Ikeda, Michihiko Koeda, Woochan Kim, Amane Tateno, Yoshiro Okubo, Hidenori Suzuki

    JOURNAL OF NIPPON MEDICAL SCHOOL   79 ( 5 )   318 - 319   2012.10

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  • [Amyloid PET imaging with [18F]AV-45]. Reviewed

    Tateno A, Okubo Y

    Nihon rinsho. Japanese journal of clinical medicine   69 Suppl 8   561 - 564   2011.10

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  • Cortical blindness caused by hypoxemia following an asthma attack Reviewed

    Tomoyuki Kunishige, Ataru Omori, Amane Tateno, Noriaki Yahata, Junko Hori

    JAPANESE JOURNAL OF OPHTHALMOLOGY   55 ( 5 )   588 - 590   2011.9

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  • Peripheral benzodiazepine receptors in patients with chronic schizophrenia: a PET study with [C-11]DAA1106 Reviewed

    Akihiro Takano, Ryosuke Arakawa, Hiroshi Ito, Amane Tateno, Hidehiko Takahashi, Ryohei Matsumoto, Yoshiro Okubo, Tetsuya Suhara

    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY   13 ( 7 )   943 - 950   2010.8

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    Inflammatory/immunological process and glial contribution are suggested in the pathophysiology of schizophrenia. We investigated peripheral benzodiazepine receptors in brains of patients with chronic schizophrenia, which were reported to be located on mitochondria of glial cells, using [C-11]DAA1106 with positron emission tomography. Fourteen patients and 14 age- and sex-matched normal controls participated in this study. PET data were analysed by two-tissue compartment model with metabolite-corrected plasma input. Clinical symptoms were assessed using the Positive and Negative Syndrome Scale. There was no significant difference between [C-11]DAA1106 binding of the cortical regions of normal controls and patients with schizophrenia, whereas the patients showed a positive correlation between cortical [C-11]DAA1106 binding and positive symptom scores. There was also a positive correlation between [C-11]DAA1106 binding and duration of illness. Although the correlations need to be interpreted very cautiously, involvement of glial reaction process in the pathophysiology of positive symptoms or progressive change of schizophrenia might be suggested.

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  • Working memory processing for human voice perception in a patient with mild cognitive impairment: An fMRI study Reviewed

    Michihiko Koeda, Amane Tateno, Kosuke Ishizaka, Tomoyuki Saijo, Yoshiro Okubo

    Journal of Nippon Medical School   77 ( 4 )   188 - 189   2010

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  • Regional cerebral blood flow in patients with orally localized somatoform pain disorder: a single photon emission computed tomography study Reviewed

    Hiroyuki Karibe, Ryosuke Arakawa, Amane Tateno, Sunao Mizumura, Tomoo Okada, Takashi Ishii, Katsuo Oshima, Mitsuhiro Ohtsu, Isao Hasegawa, Yoshiro Okubo

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   64 ( 5 )   476 - 482   2010

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    Aim:
    Somatoform pain disorder is characterized by persistent and chronic pain at one or more sites without an associated general medical condition and in which psychological factors are thought to play a role. This study aimed to investigate the pathological features of somatoform pain disorder localized to the oral region by single photon emission computed tomography (SPECT).
    Methods:
    Ten patients (nine females and one male; average age 55.0 +/- 14.4 years) having somatoform pain disorder with oral symptoms participated. SPECT was performed using N-isopropyl-4-[123I] iodoamphetamine intravenous injections, and regional cerebral blood flow (rCBF) was assessed by three-dimensional stereotactic surface projections. We also selected 12 healthy individuals (seven females and five males; average age 61.8 +/- 13.2 years) to act as controls.
    Results:
    Both the patient and control groups showed no atrophy or infarction on CT or magnetic resonance imaging. The patient group showed higher rCBF in the subcortical area, especially in the thalamus and cingulate gyri, than the control group. In contrast, the patient group showed lower rCBF in the bilateral frontal and occipital lobes as well as in the left temporal lobe.
    Conclusions:
    These results suggest that the biological process involved in somatoform pain disorder of the oral region is characterized by changes in limbic and cortical functions. The finding that somatoform pain disorder with oral symptoms is associated with brain functional changes will help to develop treatment regimes for this disorder and clarify the underlying pathology.

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  • An easy Z-score imaging system for discrimination between very early Alzheimer's disease and controls using brain perfusion SPECT in a multicentre study Reviewed

    Hiroshi Matsuda, Sunao Mizumura, Takehiko Nagao, Tsuneyoshi Ota, Tomomichi Iizuka, Kiyotaka Nemoto, Michihiro Kimura, Amane Tateno, Akiko Ishiwata, Ichiei Kuji, Heii Arai, Akira Homma

    NUCLEAR MEDICINE COMMUNICATIONS   28 ( 3 )   199 - 205   2007.3

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    Background and aim In Alzheimer's disease (AD), regional cerebral blood flow (rCBF) in the posterior cingulate gyrus and precuneus has been reported to decrease even at a very early stage. We performed a multicentre SPECT study to evaluate the discrimination ability of an easy Z-score imaging system (eZIS) by detecting an rCBF decrease in this area with a common normal database between very early AD patients at the stage of mild cognitive impairment and age-matched healthy volunteers.
    Methods Brain perfusion SPECT images of 40 Alzheimer's disease patients and 40 healthy volunteers were acquired from four gamma camera systems in different institutions. Systematic differences of SPECT images between different gamma cameras were corrected using conversion maps calculated from the SPECT images of the same brain phantom. Ten observers with various degrees of expertise graded eZIS results for receiver operating characteristic (ROC) curves. ROC curves for a positive Z-score in the volume of interest (VOI) of the posterior cingulate gyrus and precuneus were also analysed.
    Results An area under the ROC curve value (A(Z)) for ten observers showed the highest value of 0.866 on average with the smallest standard deviation of 0.027 in the condition of the lower threshold of a Z-score map of 2 without superimposition of VOI. Automated analysis of a Z-score in the VOI showed an A(Z) value of 0.895.
    Conclusion Since the degree of expertise of the observers with respect to reading eZIS did not influence the performance and an eZIS can use a common normal database by converting site-specific SPECT data to the core data, the eZIS was considered to be very useful for diagnosing early AD in routine studies in many institutions.

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  • [99m Tc]ECD-SPECTを用いた早発性および晩発性アルツハイマー病局所脳血流の比較検討

    大塚 太郎, 黄田 常嘉, 水村 直, 松田 博史, 長尾 毅彦, 根本 清貴, 館野 周, 石渡 明子, 久慈 一英, 木村 通宏, 本間 昭, 新井 平伊

    老年精神医学雑誌   18 ( 1 )   61 - 67   2007.1

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    従来からアルツハイマー病(AD)には臨床症候的、生化学的、病理学的、遺伝学的多様性が存在すると報告されている。今回、筆者らはADの多様性を解明する端緒として発症年齢に着目し、早発性アルツハイマー病(early onset Alzheimer's disease;EOAD)と晩発性アルツハイマー病(late onset Alzheimer's disease;LOAD)の局所脳血流の低下パターンの差異について検討した。NINCDS-ADRDAの診断基準を満たすprobable AD 114例をEOAD27例とLOAD87例の2群に分け、[99m Tc]ECD-SPECTを撮像し、解剖学的標準化と平滑化を加えたうえ、SPM for Windowsを用いてunpaired t-testを行った。その結果、EOADはLOADに対して側頭頭頂連合野において血流低下が高度であったのに対し、LOADではEOADに対して前部帯状回や後頭連合野において有意な脳血流低下が認められた。これらは臨床症候的・病理学的変性の分布・程度などADの多様性を反映した結果と考えられた。(著者抄録)

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    Other Link: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2007&ichushi_jid=J02464&link_issn=&doc_id=20070202230010&doc_link_id=%2Faj2rsizd%2F2007%2F001801%2F011%2F0061-0067%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Faj2rsizd%2F2007%2F001801%2F011%2F0061-0067%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

  • eZISによる超早期アルツハイマー病と健常高齢者の脳血流SPECTの鑑別 多施設共同研究

    松田 博史, 水村 直, 黄田 常嘉, 長尾 毅彦, 飯塚 友道, 根本 清貴, 木村 通宏, 舘野 周, 石渡 明子, 久慈 一英

    核医学   42 ( 3 )   301 - 301   2005.9

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  • Repetitive transcranial magnetic stimulation as treatment of poststroke depression: A preliminary study Reviewed

    RE Jorge, RG Robinson, A Tateno, K Narushima, L Acion, D Moser, S Arndt, E Chemerinski

    BIOLOGICAL PSYCHIATRY   55 ( 4 )   398 - 405   2004.2

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    Background: Depression has a significant impact on poststroke recovery and mortality. There are a proportion of Patients with poststroke depression (PSD) who do not respond to antidepressants. Repetitive Transcranial Magnetic Stimulation (rTMS) might be a safe and effective alternative in these refractory cases.
    Methods: We conducted a randomized, parallel, double-blind study of active versus sham left prefrontal rTMS in patients with refractory PSD. After discontinuing antidepressants, patients were randomly assigned to receive 10 sessions of active (10 Hz, 110% of the motor threshold, 20 trains of 5 seconds duration) or sham left prefrontal rTMS. Efficacy measures included HAM-D scores, response and remission rates. Patients completed a neuropsychological battery at baseline and after completing the protocol.
    Results: When compared with sham stimulation, 10 sessions of active rTMS of the left dorsolateral prefrontal cortex were associated with a significant reduction of depressive symptoms. This reduction was not influenced by patient's age, type or location of stroke, volume of left frontal leukoaraiosis or by the distance of the stimulating coil to the prefrontal cortex. However, there was a significant positive correlation between the percentage of reduction of Ham-D scores and frontal gray and white matter volumes. There were no significant changes in cognitive functioning between the active and the sham stimulation groups. In addition, there were few and mild adverse effects that were equally distributed among groups.
    Conclusions: Taken together, these preliminary,findings suggest that rTMS may be an effective and safe treatment alternative for patients with refractory depression and stroke.

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  • Major depression following traumatic brain injury Reviewed

    RE Jorge, RG Robinson, D Moser, A Tateno, B Crespo-Facorro, S Arndt

    ARCHIVES OF GENERAL PSYCHIATRY   61 ( 1 )   42 - 50   2004.1

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    Backgroud: Major depression is a frequent psychiatric complication among patients with traumatic brain injury (TBI). To our knowledge, however, the clinical correlates of major depression have not been extensively studied.
    Objective: To determine the clinical, neuropsychological, and structural neuroimaging correlates of major depression occurring after TBI.
    Design: Prospective, case-controlled, surveillance study conducted during the first year after the traumatic episode occurred.
    Settings: University hospital level I trauma center and a specialized rehabilitation unit.
    Methods: The study group consisted of 91 patients with TBI. In addition, 27 patients with multiple traumas but without evidence of central nervous system injury constituted the control group. The patients' conditions were evaluated at baseline and at 3, 6, and 12 months after the traumatic episode. Psychiatric diagnosis was made using a structured clinical interview and DSM-IV criteria. Neuropsychological testing and quantitative magnetic resonance imaging were performed at the 3-month follow-up visit.
    Results: Major depressive disorder was observed in 30 (33%) of 91 patients during the first year after sustaining a TBI. Major depressive disorder was significantly more frequent among patients with TBI than among the controls. Patients with TBI who had major depression were more likely to have a personal history of mood and anxiety disorders than patients who did not have major depression. Patients with major depression exhibited comorbid anxiety (76.7%) and aggressive behavior (56.7%). Patients with major depression had significantly greater impairment in executive functions than their nondepressed counterparts. Major depression was also associated with poorer social functioning at the 6-and 12-month follow-up, as well as significantly reduced left prefrontal gray matter volumes, particularly in the ventrolateral and dorsolateral regions.
    Conclusions: Major depression is a frequent complication of TBI that hinders a patient's recovery. It is associated with executive dysfunction, negative affect, and prominent anxiety symptoms. The neuropathological changes produced by TBI may lead to deactivation of lateral and dorsal prefrontal cortices and increased activation of ventral limbic and paralimbic structures including the amygdala.

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  • Pathological laughing and crying following traumatic brain injury. Reviewed

    Tateno A, Jorge RE, Robinson RG

    The Journal of neuropsychiatry and clinical neurosciences   16 ( 4 )   426 - 434   2004

  • Regional cerebral blood flow in vascular depression assessed by 123I-IMP SPECT Reviewed

    Mahito Kimura, Kengo Shimoda, Sunao Mizumura, Amane Tateno, Tatsuma Fujito, Takao Mori, Shunkichi Endo

    Journal of Nippon Medical School   70 ( 4 )   321 - 326   2003.8

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    Objective: As the prevalence of white matter hyperintensities detected on T 2 weighted MRI scans in patients with late-onset depression is higher than that in nondepressed patients, the concept of "vascular depression" (VDep) was introduced in 1997. However, the pathology of vascular depression has not been clarified. This study examined the differences in functional imaging between vascular and non-vascular depression (non-VDep). Methods: We utilized 123I-IMP single photon emission computed tomography (SPECT) to compare regional cerebral blood flows (rCBF) between 9 patients with VDep (Krishnan criteria) and 11 age- and sex-matched patients with non-VDep in both depressed and remitted states. Results: In both VDep and non-VDep patients, mean rCBF increased significantly as depression improved, partially aided by changes in left anterior temporal blood flow. In addition, compared to non-VDep patients, the left anterior frontal rCBF for VDep patients was significantly lower in both depressed and remitted states. Conclusions: Left anterior temporal rCBF therefore appears to represent a state marker that increases as symptoms associated with late-onset depression improve. regardless of vascular changes. Furthermore, in VDep patients, left anterior frontal rCBF was low in both states compared to non-VDep patients, and might not only represent a trait marker, but also correlated with the duration of disease and likelihood of recurrence and relapse.

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  • Treatment of poststroke generalized anxiety disorder comorbid with poststroke depression - Merged analysis of nortriptyline trials Reviewed

    M Kimura, A Tateno, RG Robinson

    AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY   11 ( 3 )   320 - 327   2003.5

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    The existence of anxiety disorders plays an important role in the prognosis and associated impairment among patients with poststroke depression. The authors examined the efficacy of nortriptyline treatment for patients with comorbid generalized anxiety disorder (GAD) and depression after stroke. Methods: Data from three studies were merged to provide 27 patients with comorbid GAD and depression, who participated in double-blind treatment studies comparing nortriptyline (N=13) and placebo (N=14). Severity of anxiety was measured with the Hamilton Rating Scale for Anxiety (Ham A), and severity of depression was measured with the Hamilton Rating Scale for Depression (Ham-D). Activities of daily living were assessed by use of the Johns Hopkins Functioning Inventory (JHFI). Results: There were no significant differences between the nortriptyline and placebo groups in demographic characteristics, stroke type, and neurological findings. Patients receiving nortriptyline treatment showed significantly greater improvement on the Ham A, Ham-D, and JHFI than patients receiving placebo. The anxiety symptoms showed earlier improvement than depressive symptoms inpatients treated with nortriptyline. Conclusions: These findings suggest that poststroke GAD comorbid with poststroke depression may be effectively treated with nortriptyline, and data indicate the need for a trial specifically designed to examine treatment of anxiety disorder.

    DOI: 10.1097/00019442-200305000-00009

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  • Clinical correlates of aggressive behavior after traumatic brain injury Reviewed

    Amane Tateno, Ricardo E. Jorge, Robert G. Robinson

    Journal of Neuropsychiatry and Clinical Neurosciences   15 ( 2 )   155 - 160   2003

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    The authors assessed aggressive behavior in 89 patients with traumatic brain injury (TBI) and 26 patients with multiple trauma but without TBI using a quantitative scale (the Overt Aggression Scale) and examined its clinical correlates. Aggressive behavior was found in 33.7% of TBI patients and 11.5% of patients without TBI during the first 6 months after injury. Aggressive behavior was significantly associated with the presence of major depression, frontal lobe lesions, poor premorbid social functioning, and a history of alcohol and substance abuse. Interventions aimed at treatment of depression and substance abuse and enhancing social support may help reduce the severity of this disruptive behavior.

    DOI: 10.1176/jnp.15.2.155

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  • Phenomenological characteristics of poststroke depression - Early-versus late-onset Reviewed

    A Tateno, M Kimura, RG Robinson

    AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY   10 ( 5 )   575 - 582   2002.9

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    Objective: Authors compared poststroke major (n = 17) or minor (n = 28) depression diagnosed 3 to 6 months poststroke with major (n = 16) or minor (n = 22) depression diagnosed at 12 to 24 months to identify changes in the phenomenological characteristics of poststroke depression over time. Methods: Depressive symptoms were divided into vegetative, psychological symptoms, and melancholic features elicited by the Present State Exam (PSE). Patients were also examined for severity of depression, social impairment, and neurological findings. Results: Early-onset poststroke major depression was associated with a higher frequency of vegetative symptoms and larger lesion volume than late-onset major depression. Similarly, early-onset minor depression was associated with poorer social functioning and a higher frequency of melancholic, vegetative, and psychological symptoms than late-onset minor depression. Conclusion: These findings suggest that the phenomenological characteristics of both major and minor poststroke depression change over time and that both early-onset major and minor poststroke depression may result from similar etiological mechanisms provoked by brain injury.

    DOI: 10.1097/00019442-200209000-00011

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  • Comparison of cognitive impairment associated with major depression following stroke versus traumatic brain injury Reviewed

    A Tateno, Y Murata, RG Robinson

    PSYCHOSOMATICS   43 ( 4 )   295 - 301   2002.7

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    Several studies have reported an association between cognitive impairment and major depression following stroke but failed to find a similar association among patients with traumatic brain injury (TBI). This study examined the hypothesis that age differences between stroke and TBI patients would account for the differences in the effect of major depression on cognitive function. We examined subjects' cognitive function using the Mini-Mental State Examination and compared findings among patients with stroke or TBI. Results indicated that stroke patients with major depression (N = 73) were significantly older and more cognitively impaired than similar TBI patients (N = 35), even after matching patients for lesion volume and years of education. After matching for age, however, there was no association of major depression with cognitive impairment in this relatively young stroke population. These findings support the hypothesis that age, presumably related to physiological response to brain injury accounts for differences in the effect of major depression on cognitive function between stroke and TBI patients.

    DOI: 10.1176/appi.psy.43.4.295

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  • The effect of poststroke depressoin on recovery from stroke Reviewed

    Amane Tateno, Robert G. Robinson

    PSYCHOGERIATRICS   2 ( 2 )   73 - 84   2002.3

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  • P3 and rCBF characteristics of patients with major depression in depressed and remitted phases Reviewed

    A Tateno, M Hada, M Kimura, T Mori, H Suzuki, S Endo, S Mizumura

    BRAIN TOPOGRAPHY TODAY   1147   445 - 449   1997

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    Background. Depressive episodes are likely to be associated with reversible brain states. These can be examined with a variety of methods, such as ERP, SPECT or PET. Previous studies have reported that P300 amplitudes reduced in the depressed phase and recovered in the remitted phase. There have been some reports that anterior cingulate blood flow reduced in the depressed phase and recovered in the remitted phase.
    Method. Five right-handed depressed patients were studied in both the depressed and remitted phases by using I-123-IMP SPECT and ERP.
    Results. There were no significant differences in regional cerebral blood flows (rCBFs) between the depressed and remitted phases. Four of the five subjects showed parallel changes of rCBF in the anterior cingulate, frontal cortex and basal ganglia between the depressed and remitted phases. The changes of P300 amplitude at P4 between the depressed and remitted phases had positive correlation with those of rCBFs in the bilateral thalamus and right cingulate. The changes of P300 amplitude at Pt had negative correlation with those of rCBFs in the right frontal and left basal ganglia, In the anxious type, P300 amplitudes at Pt decreased and rCBFs in the frontal cortex and anterior cingulate increased. Conversely, in the retarded type, P300 amplitudes at Pt increased and rCBFs in the frontal cortex and anterior cingulate decreased.
    Conclusion. Our findings of the parallel changes of rCBF in the anterior cingulate, frontal cortex and basal ganglia between the depressed and remitted phases indicates that these neuroanatomical circuits may be involved in depression. The anxious type may be different from the retarded type in the changes of rCBF between the depressed and remitted phases in the frontal cortex and anterior cingulate, and in the changes of P300 amplitudes.

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Books

  • 今日の精神疾患治療指針第2版

    舘野 周( Role: Contributor精神科面接、診断と各種検査(脳画像検査))

    医学書院  2016.10 

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  • 脳卒中における臨床神経精神医学 第2版

    舘野 周( Role: Joint translatorp43-92)

    星和書店  2013.7 

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  • 精神科領域からみた心身症:専門医のための精神科臨床リュミエール

    舘野 周( Role: Contributor脳内イメージングからみた心身医学:疼痛障害の画像所見)

    中山書店  2011.8 

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  • ポケット精神科

    舘野 周( Role: Contributor検査(脳機能画像))

    金芳堂  2010.6 

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  • ポケット精神科第2版

    舘野 周( Role: Contributor検査(脳機能画像))

    金芳堂  2010.6 

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  • コア・ローテイション精神科第2版

    舘野 周( Role: Contributor検査(脳機能画像))

    金芳堂  2007.3 

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  • コア・ローテイション精神科

    舘野 周( Role: Contributor検査(脳機能画像))

    金芳堂  2004.7 

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  • International Congress Series

    TATENO Amane( Role: Joint authorChanges in regional cerebral blood flow on recovery from depression-comparison of vascular depression and non-vascular depression.)

    Elsevier Science  2002.4 

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  • 脳卒中の臨床神経精神医学

    舘野 周( Role: Joint translator)

    星和書店  2002.2 

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  • Brain Topography Today

    TATENO Amane( Role: Joint authorP3 and rCBF characteristics of patients with major depression in depressed and remitted phases.)

    Elsevier Science B.V.  1998.3 

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Misc.

  • 経頭蓋直流刺激による安静時機能的MRI施行時の機能的結合に対する影響:予備的fMRI研究

    肥田道彦, 濱智子, 中島創一郎, 秋山友美, 池田裕美子, 舘野周, 鈴木秀典, 大久保善朗

    日本生物学的精神医学会(Web)   41st   2019

  • 経頭蓋直流刺激による言語流暢性課題施行時の脳賦活に対する影響:予備的fMRI研究

    中島創一郎, 肥田道彦, 濱智子, 秋山友美, 池田裕美子, 舘野周, 鈴木秀典, 大久保善朗

    日本生物学的精神医学会(Web)   41st   2019

  • 高齢者の不安・うつ症状に対する認知行動療法の試み-一事例からみる介入プログラムの安全性・有用性の可能性について-

    樫村正美, 野村俊明, 野村俊明, 石渡明子, 舘野周

    老年精神医学雑誌   30   2019

  • アミロイドPET時代の認知症診療;アミロイド陽性と陰性の臨床的意義を考える 老年期うつ病におけるアミロイドPETの臨床的意義

    舘野 周, 大久保 善朗

    老年精神医学雑誌   29 ( 増刊II )   135 - 135   2018.6

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  • 認知症の介護家族を対象とした心理社会的介入の試み 日本語版STARTの安全性と有用性の予備的検討

    樫村 正美, 野村 俊明, 石渡 明子, 舘野 周, 川西 智也, 北村 伸

    老年精神医学雑誌   29 ( 増刊II )   175 - 175   2018.6

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  • Effect of Tramadol on Nucleus Accumbens Activation in Monetary Reward Anticipation

    Ikeda Yumiko, Tateno Amane, Okubo Yoshiro, Suzuki Hidenori

    Nihon Ika Daigaku Igakkai Zasshi   14 ( 3 )   98 - 99   2018.6

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  • PETイメージングを用いたうつ病におけるセロトニン1B受容体評価研究

    野上 毅, 守屋 洋紀, 増岡 孝浩, 坂寄 健, 舘野 周, 大久保 善朗

    先進医薬研究振興財団研究成果報告集   2017年度   24 - 25   2018.3

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  • ブプロピオンによる聴覚情動認知・機能的結合に対する効果:fMRI研究

    濱智子, 肥田道彦, 池田裕美子, 舘野周, 鈴木秀典, 大久保善朗

    日本ヒト脳機能マッピング学会プログラム・抄録集   20th   79   2018

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  • 軟性ドルーゼンと脳内アミロイドβの関連

    北川 順久, 正田 千穂, 島田 宏之, 篠島 亜里, 湯澤 美都子, 舘野 周, 大久保 善朗

    日大医学雑誌   76 ( 6 )   326 - 326   2017.12

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  • 【超高齢化社会の精神科診療】 老年期うつ病におけるアミロイドイメージングの意義

    舘野 周, 大久保 善朗

    臨床精神医学   46 ( 11 )   1395 - 1401   2017.11

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  • The amyloid imaging for geriatric depression

    舘野 周, 大久保 善朗

    臨床精神医学 = Japanese journal of clinical psychiatry   46 ( 11 )   1395 - 1401   2017.11

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  • 若年性統合失調症に対し、アリピプラゾール持続型注射剤が奏功した一例

    藤本 泰樹, 野上 毅, 肥田 道彦, 成重 竜一郎, 舘野 周, 大久保 善朗

    精神神経学雑誌   119 ( 10 )   802 - 802   2017.10

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  • 音声情動認知時の機能的結合に対するブプロピオンの効果 予備的fMRI研究

    濱 智子, 肥田 道彦, 池田 裕美子, 舘野 周, 鈴木 秀典, 大久保 善朗

    日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集   39回・47回   164 - 164   2017.9

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  • ブプロピオンの情動認知時脳賦活に与える影響 予備的fMRI研究

    肥田 道彦, 濱 智子, 池田 裕美子, 舘野 周, 鈴木 秀典, 大久保 善朗

    日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集   39回・47回   154 - 154   2017.9

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  • [11C]-(+)-PHNOを用いたblonanserinによるドパミンD3受容体占有率の評価

    坂寄 健, キム・ウーチャン, 舘野 周, 大久保 善朗

    日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集   39回・47回   195 - 195   2017.9

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  • EFFECT OF CNTNAP2 POLYMORPHISMS ON CEREBRAL RESPONSE TO HUMAN VOICE PERCEPTION AND HANDEDNESS: AN FMRI STUDY Reviewed

    Michihiko Koeda, Atsushi Watanabe, Kumiko Tsuda, Miwako Matsumoto, Yumiko Ikeda, Woochan Kim, Amane Tateno, Banyar Than Naing, Hiroyuki Karibe, Takashi Shimada, Hidenori Suzuki, Masato Matsuura, Yoshiro Okubo

    JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY   88 ( 8 )   E25 - E26   2017.8

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    DOI: 10.1136/jnnp-2017-BNPA.55

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  • MAZINDOL EFFECT ON CEREBRAL RESPONSE TO NONVERBAL AFFECTIVE VOCALISATION IN HEALTHY INDIVIDUALS: AN FMRI STUDY Reviewed

    Michihiko Koeda, Yumiko Ikeda, Amane Tateno, Hidenori Suzuki, Yoshiro Okubo

    JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY   88 ( 8 )   E35 - E36   2017.8

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    DOI: 10.1136/jnnp-2017-BNPA.80

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  • 高齢者に向けた精神療法の応用 認知症患者とその介護者を対象とした認知行動的なアプローチ

    樫村 正美, 野村 俊明, 舘野 周, 石渡 明子

    日本抗加齢医学会総会プログラム・抄録集   17回   113 - 113   2017.6

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  • 軟性ドルーゼンと脳内アミロイドβの関連

    正田 千穂, 北川 順久, 島田 宏之, 篠島 亜里, 湯澤 美都子, 舘野 周, 大久保 善朗

    日本眼科学会雑誌   121 ( 臨増 )   240 - 240   2017.3

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  • 老年期うつ病のドーパミントランスポーターイメージング

    守屋 洋紀, 増岡 孝浩, 坂寄 健, 金 禹さん, 新貝 慈利, 舘野 周, 大久保 善朗

    先進医薬研究振興財団研究成果報告集   2016年度   14 - 15   2017.3

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  • 痛みの声を聴いたときの脳活動

    冨澤 大佑, 山崎 陽子, 嶋田 昌彦, 肥田 道彦, 舘野 周, 大久保 善朗

    日本慢性疼痛学会プログラム・抄録集   46回   60 - 60   2017.2

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  • ロラゼパム投与時の不安軽減度と恐怖感情認知脳内ネットワークの分布の関連:機能的MRI研究

    肥田道彦, 長谷武志, 濱智子, 濱智子, 池田裕美子, 舘野周, 鈴木秀典, 大久保善朗

    日本臨床精神神経薬理学会プログラム・抄録集   27th   119   2017

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  • 恐怖音声認知・脳処理時の機能的結合に対するプラセボ・ロラゼパムの効果 機能的MRI研究

    肥田 道彦, 長谷 武志, 濱 智子, 池田 裕美子, 八幡 憲明, 舘野 周, 高橋 英彦, 松浦 雅人, 鈴木 秀典, 大久保 善朗

    日本神経精神薬理学会年会プログラム・抄録集   46回   215 - 215   2016.7

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  • 老年期うつ病のドーパミントランスポーターイメージング

    守屋 洋紀, 坂寄 健, 金 禹瑣, 増岡 孝浩, 新貝 慈利, 舘野 周, 大久保 善朗

    精神神経学雑誌   ( 2016特別号 )   S368 - S368   2016.6

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  • 老年期うつ病と認知症の関連 うつ病と認知症の関連 神経画像所見から

    舘野 周, 大久保 善朗

    老年精神医学雑誌   27 ( 増刊II )   149 - 149   2016.6

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  • 難治性うつ状態に電気けいれん療法が有効であったアミロイド関連うつ病の一例 3年の長期入院からの回復

    小林 まどか, 明野 薫, 肥田 道彦, 上田 諭, 舘野 周, 大久保 善朗

    老年精神医学雑誌   27 ( 増刊II )   168 - 168   2016.6

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  • 電気けいれん療法がドーパミントランスポーターに及ぼす影響

    増岡 孝浩, 坂寄 健, 舘野 周, 大久保 善朗

    精神神経学雑誌   ( 2016特別号 )   S482 - S482   2016.6

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  • 軽度認知機能障害患者の顔認知時の脳機能に関する予備的検討 機能的MRI研究

    肥田 道彦, 舘野 周, 大久保 善朗

    老年精神医学雑誌   27 ( 増刊II )   172 - 172   2016.6

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  • イメージングバイオマーカーを用いた高齢者の精神神経疾患の評価 アミロイドPETイメージングを用いた高齢者の精神疾患の評価

    舘野 周

    精神神経学雑誌   ( 2016特別号 )   S287 - S287   2016.6

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  • アミロイドβ集積の経時変化 [18F]florbetapirを用いたPET研究

    山本 憲, 坂寄 健, 舘野 周, 大久保 善朗

    精神神経学雑誌   ( 2016特別号 )   S527 - S527   2016.6

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  • 【認知症の診断と治療:最近の進歩】 アミロイドイメージングによる認知症の診断

    舘野 周, 大久保 善朗

    臨床精神医学   45 ( 4 )   433 - 439   2016.4

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  • Diagnosis of dementia by amyloid imaging

    舘野 周, 大久保 善朗

    臨床精神医学   45 ( 4 )   433 - 439   2016.4

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  • 薬剤性パーキンソンニズムのドパミン分子イメージング

    坂寄 健, 守屋 洋紀, 増岡 孝浩, 舘野 周, 大久保 善朗

    先進医薬研究振興財団研究成果報告集   2015年度   4 - 5   2016.3

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  • セルトラリンのドパミン神経伝達への作用に関するPET研究

    金禹瑣, 舘野周, 池田裕美子, 坂寄健, 荒川亮介, 荒川亮介, 鈴木秀典, 大久保善朗

    日本生物学的精神医学会(Web)   38th   168 (WEB ONLY)   2016

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  • プラセボ・ロラゼパム投与時の恐怖感情認知脳内ネットワークと不安軽減度の関連:機能的MRI研究

    肥田道彦, 長谷武志, 長谷武志, 濱智子, 濱智子, 池田裕美子, 八幡憲明, 舘野周, 高橋英彦, 松浦雅人, 鈴木秀典, 大久保善朗

    日本生物学的精神医学会(Web)   38th   60 (WEB ONLY)   2016

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  • 軽度認知障害における18F-AV45(Florbetapir)-PETによるアミロイド蓄積評価

    石渡 明子, 水村 直, 舘野 周, 大久保 善朗, 木村 和美

    臨床神経学   55 ( Suppl. )   S246 - S246   2015.12

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  • 【認知症の最前線】 PET検査 アミロイドイメージングとタウイメージング

    大久保 善朗, 舘野 周

    精神科   27 ( 5 )   304 - 309   2015.11

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  • パーキンソン病に併発した妄想性障害に対してECTを行った1例

    石澤 純平, 朝山 健太郎, 上田 諭, 舘野 周, 大久保 善朗

    精神神経学雑誌   117 ( 11 )   941 - 941   2015.11

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  • Amyloid and tau imaging with positron emission tomography

    大久保 善朗, 舘野 周

    精神科 = Psychiatry   27 ( 5 )   304 - 309   2015.11

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  • ブプロピオンのドパミン神経伝達への作用に関するPET研究

    金 禹瑣, 舘野 周, 池田 裕美子, 坂寄 健, 荒川 亮介, 鈴木 秀典, 大久保 善朗

    日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集   37回・45回   183 - 183   2015.9

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  • EFFECT OF CNTNAP2 POLYMORPHISMS ON CEREBRAL RESPONSE TO HUMAN VOICE PERCEPTION AND HANDEDNESS: AN FMRI STUDY Reviewed

    Michihiko Koeda, Atsushi Watanabe, Kumiko Tsuda, Miwako Matsumoto, Yumiko Ikeda, Woochan Kim, Amane Tateno, Banyar Than Naing, Hiroyuki Karibe, Takashi Shimada, Hidenori Suzuki, Masato Matsuura, Yoshiro Okubo

    JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY   86 ( 9 )   2015.9

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    DOI: 10.1136/jnnp-2015-311750.64

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  • うつ病のドーパミントランスポーターイメージング

    守屋 洋紀, 増岡 孝浩, 坂寄 健, 金 禹瑣, 舘野 周, 大久保 善朗

    精神神経学雑誌   ( 2015特別 )   S361 - S361   2015.6

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  • 薬剤性パーキンソンニズムのドパミン分子イメージング

    坂寄 健, 舘野 周, 大久保 善朗

    精神神経学雑誌   ( 2015特別 )   S770 - S770   2015.6

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  • ベータアミロイドの集積が認知機能に与える影響について [18F]florbetapir PETによる調査

    山本 憲, 坂寄 健, 舘野 周, 大久保 善朗

    精神神経学雑誌   ( 2015特別 )   S768 - S768   2015.6

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  • うつ病の危険因子と予防 認知症と関連するうつ病

    TATENO AMANE, OKUBO YOSHIRO

    臨床精神医学   44 ( 4 )   561 - 568   2015.4

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  • Dementia-associated depression

    舘野 周, 大久保 善朗

    臨床精神医学   44 ( 4 )   561 - 568   2015.4

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  • 薬剤性パーキンソンニズムのドパミン分子イメージング

    坂寄 健, 増岡 孝浩, 舘野 周, 大久保 善朗

    先進医薬研究振興財団研究成果報告集   2014年度   8 - 9   2015.3

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  • セレギリンのドパミン情報伝達系への作用に関するPET研究

    金 禹瑣, 舘野 周, 池田 裕美子, 坂寄 健, 荒川 亮介, 鈴木 秀典, 大久保 善朗

    日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集   24回・44回   195 - 195   2014.11

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  • 非言語性感情音声聴取時の脳賦活に対するマジンドールの効果 fMRI研究

    肥田 道彦, 池田 裕美子, 舘野 周, 鈴木 秀典, 大久保 善朗

    日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集   24回・44回   160 - 160   2014.11

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  • DAT SPECT診断の線条体集積比における操作者間、解析ツール(QSPECT・DATview)間の再現性

    曽原 康二, 水村 直, 桑子 智之, 桐山 智成, 福嶋 善光, 永山 寛, 舘野 周, 汲田 伸一郎

    核医学   51 ( 3 )   273 - 273   2014.9

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  • 薬物依存のPET画像研究 臨床応用の可能性

    舘野 周

    日本アルコール・薬物医学会雑誌   49 ( 4 )   253 - 253   2014.8

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  • 反復性傾眠症1症例の傾眠期/間欠期におけるFDG-PETによる糖代謝の比較

    朝山 健太郎, 舘野 周, 大久保 善朗

    日本睡眠学会定期学術集会プログラム・抄録集   39回   226 - 226   2014.7

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  • Effects of bupropion on reward processing in healthy individuals: a pharmacological fMRI study Reviewed

    Takuya Funayama, Yumiko Ikeda, Amane Tateno, Hidehiko Takahashi, Yoshiro Okubo, Haruhisa Fukayama, Hidenori Suzuki

    JOURNAL OF PHARMACOLOGICAL SCIENCES   124   213P - 213P   2014

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  • Modafinil affects the neural activity during attention in healthy adults Reviewed

    Yumiko Ikeda, Takuya Funayama, Amane Tateno, Hidehiko Takahashi, Yoshiro Okubo, Hidenori Suzuki

    JOURNAL OF PHARMACOLOGICAL SCIENCES   124   212P - 212P   2014

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  • 人の声に選択的な脳賦活部位に対するCNTNAP2多型の影響:機能的MRI研究

    肥田道彦, 渡辺淳, 池田裕美子, キム ウーチャン, 舘野周, 苅部洋行, 鈴木秀典, 松浦雅人, 大久保善朗

    日本生物学的精神医学会誌   384   2014

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  • Burning Mouth Syndromeの精神科診断に関する検討

    TOMISAWA DAISUKE, KAWASHIMA MASATO, SHIMADA AKIHIKO, TATENO AMANE, OKUBO YOSHIRO

    日本歯科心身医学会雑誌   28 ( 1月2日 )   48 - 49   2013.12

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  • 精神医学のフロンティア 統合失調症の脳形態変化における閉経の影響について

    福田 一, 伊藤 逸生, 舘野 周, 野上 毅, 田井治 康友, 荒川 亮介, 須原 哲也, 浅井 邦彦, 大久保 善朗

    精神神経学雑誌   115 ( 12 )   1178 - 1185   2013.12

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    統合失調症の脳形態変化における閉経の影響について、患者群を閉経患者と非閉経患者の2群に分けMRIを用いて調査した。最終月経からMRI撮像までの期間が12ヵ月以上である統合失調症女性患者20名と同時期が12ヵ月未満であり閉経患者群と年齢を一致させた統合失調症女性患者20名(平均41.8±9.0歳)を対象とした。分析の結果、非閉経患者群と比較し、閉経患者群において左中前頭回の灰白質に有意な体積減少を認めた。一方、非閉経患者群が閉経患者群と比較して有意に体積減少している部位は認められなかった。閉経患者20名において、閉経後経過年数と脳体積の相関を調べた結果、右上前頭回の灰白質体積と閉経後経過年数に負の相関が認められた。健常者が閉経する平均年齢は50から52歳の間であるとされるが、今回の閉経患者群においては、若年期に最終月経がきており、原因の一つに抗精神薬の副作用であることが考えられた。

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  • [11]DASBを用いたトラマドールのセロトニントランスポーターの占有率についての陽電子放射断層撮影(PET)研究 鎮痛効果の作用機序と抗うつ作用の可能性

    小川 耕平, 舘野 周, 荒川 亮介, 坂寄 健, 池田 裕美子, 鈴木 秀典, 大久保 善朗

    日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集   23回・43回   182 - 182   2013.10

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  • Florbetapirアミロイドイメージングにおける全脳灰白質/白質集積比を用いた診断法

    佐藤 英尊, 舘野 周, 石原 圭一, 須田 匡也, 大久保 善郎, 汲田 伸一郎

    核医学   50 ( 3 )   S181 - S181   2013.9

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  • prochlorperazineとparoxetineの併用でパーキンソン症状が出現した1症例

    冨田 理紗子, 大久保 善朗, 舘野 周, 山本 正浩, 澤谷 篤, 能登 雅明, 坂寄 健, 山本 憲

    精神神経学雑誌   ( 2013特別 )   S - 573   2013.5

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  • 希望の性別の妊娠児でないことを背景に心気妄想を生じたうつ病の症例

    坂寄 健, 石田 留生, 成重 竜一郎, 上田 諭, 舘野 周, 大久保 善朗

    精神神経学雑誌   ( 2013特別 )   S - 551   2013.5

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  • モダフィニルのPET神経画像評価

    金 禹瑣, 舘野 周, 坂寄 健, 荒川 亮介, 大久保 善朗

    精神神経学雑誌   ( 2013特別 )   S - 684   2013.5

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  • ドーパミントランスポーターイメージングによる電気けいれん療法の作用機序に関する研究

    NOTO MASAAKI, SAKAYORI KEN, UEDA SATOSHI, TATENO AMANE, OKUBO YOSHIRO

    精神薬療研究年報   ( 45 )   27 - 28   2013.3

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  • Effects of modafinil on reward processing in healthy individuals: pharmacological fMRI Reviewed

    Takuya Funayama, Yumiko Ikeda, Amane Tateno, Hidehiko Takahashi, Yoshiro Okubo, Haruhisa Fukayama, Hidenori Suzuki

    JOURNAL OF PHARMACOLOGICAL SCIENCES   121   217P - 217P   2013

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  • 歯科領域における精神科コンサルテーション・リエゾン(CL)診療でのM.I.N.I.(精神疾患簡易構造化面接)の使用の試み

    冨澤 大佑, 川島 正人, 嶋田 昌彦, 舘野 周, 大久保 善朗

    日本歯科心身医学会雑誌   27 ( 1月2日 )   76 - 77   2012.12

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  • 精神科コンサルテーション・リエゾン診療が有効であったセネストパチーの一症例

    冨澤 大佑, 川島 正人, 嶋田 昌彦, 舘野 周, 大久保 善朗

    日本歯科心身医学会雑誌   27 ( 1月2日 )   97 - 97   2012.12

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  • ECT経過中に認知機能障害を呈し、異なる経過で改善した老年期うつ病の二症例

    竹村 雅代, 舘野 周, 山本 正浩, 澤谷 篤, 上田 諭, 大久保 善朗

    精神神経学雑誌   ( 2012特別 )   S - 475   2012.5

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  • 認知症周辺症状に対する薬物治療 抑肝散、フルボキサミンでランダム化比較試験を行って

    寺西 美佳, 栗田 征武, 西野 敏, 武吉 健児, 沼田 由紀夫, 佐藤 忠宏, 下田 健吾, 舘野 周, 木村 真人, 大久保 善朗

    精神神経学雑誌   ( 2012特別 )   S - 546   2012.5

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  • 日本語版自己記入式うつ症状尺度(Inventory of Depressive Symptomatology-self report:IDS-SR)の開発

    藤澤 大介, 佐渡 充洋, 中川 敦夫, 舘野 周, 川島 義高, 菊地 俊暁, 満田 大, 野崎 昭子, 新福 正機, 岩下 覚, 大野 裕

    精神神経学雑誌   108th ( 2012特別 )   S - 480   2012.5

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  • 東京ルールに基づいて当院高度救命救急医療センターを経て精神科受診となった症例について

    冨田 理紗子, 山本 正浩, 舘野 周, 大高 靖史, 川島 義高, 朝山 健太郎, 大久保 善朗

    精神神経学雑誌   ( 2012特別 )   S - 451   2012.5

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  • 精神科臨床実習の実態と問題点

    齊藤 卓弥, 成重 竜一郎, 舘野 周, 大久保 善朗

    精神神経学雑誌   ( 2012特別 )   S - 485   2012.5

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  • 眼窩および下内側面皮質下白質切截術50年経過後の頭部拡散テンソル画像

    朝山 健太郎, 山口 祐司, 澤谷 篤, 山本 正浩, 舘野 周, 大久保 善朗

    精神神経学雑誌   ( 2012特別 )   S - 301   2012.5

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  • ETCを契機にセロトニン症候群をきたした二症例

    坂寄 健, 滝沢 勇一, 一宮 哲哉, 上田 諭, 舘野 周, 大久保 善朗

    精神神経学雑誌   ( 2012特別 )   S - 474   2012.5

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  • アミロイドイメージングによる高齢者うつ病性仮性認知症の病態診断

    OKUBO YOSHIRO, TATENO AMANE, SAKAYORI KEN, SEKINE MIZUHO

    精神薬療研究年報   ( 44 )   25 - 26   2012.3

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  • Caffeine effects on attentional networks: a pharmacological fMRI study Reviewed

    Yumiko Ikeda, Michihiko Koeda, Woochan Kim, Noriaki Yahata, Hidehiko Takahashi, Amane Tateno, Yoshiro Okubo, Hidenori Suzuki

    JOURNAL OF PHARMACOLOGICAL SCIENCES   118   263P - 263P   2012

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  • Modafinil使用時の音声情動認知の脳活動に関するfunctional MRI研究

    長濱健一郎, 戸田由美子, 肥田道彦, 池田裕美子, 舘野周, 鈴木秀典, 大久保善朗

    日本精神科診断学会プログラム・抄録集   32nd   114   2012

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  • 精神疾患の臨床病態評価に向けた音声感情認知評価法の開発

    長濱 健一郎, 戸田 由美子, 原 真由美, 野々垣 香織, 園木 健太郎, 肥田 道彦, 舘野 周, 大久保 善朗

    日本医科大学医学会雑誌   7 ( 4 )   224 - 224   2011.10

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  • 【認知症学(上)-その解明と治療の最新知見-】 臨床編 認知症診断に用いられる検査診断学とバイオマーカー 各論 [18F]AV-45によるアミロイドイメージング

    舘野 周, 大久保 善朗

    日本臨床   69 ( 増刊8 認知症学(上) )   561 - 564   2011.10

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  • Global phase 2b efficacy and safety trial of florbetaben for beta-amyloid brain positron emission tomography in Alzheimer's disease

    O. Sabri, H. Gertz, K. Ischihara, A. Tateno, A. Drzezga, T. Grimmer, M. Senda, Y. Yamamoto, F. Hiemeyer, I. McKeith, J. O'Brien, Z. Walker, C. Reininger, J. Seibyl, H. Barthel

    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING   38   S121 - S121   2011.10

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  • 医学生を対象とする精神障害に関するチュートリアル教育の試み 精神障害に関する知識と偏見(第2報)

    伊藤 滋朗, 舘野 周, 川島 義高, 野村 俊明, 大久保 善朗

    日本社会精神医学会雑誌   20 ( 3 )   271 - 271   2011.7

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  • Global phase 2b trial on florbetaben for beta-amyloid brain PET in Alzheimer's disease Reviewed

    Sabri Osama, Ischihara Keiichi, Tateno Amane, Drzezga Alexander, Grimmer Timo, Senda Michio, Yamamoto Yasuji, Hiemeyer Florian, Reininger Cornelia, Barthel Henryk

    JOURNAL OF NUCLEAR MEDICINE   52   2011.5

  • 認知症患者の中核症状、周辺症状および日常生活動作能力の関係について

    寺西 美佳, 栗田 征武, 西野 敏, 武吉 健児, 沼田 由紀夫, 佐藤 忠宏, 中畑 則道, 舘野 周, 大久保 善朗

    老年精神医学雑誌   22 ( 2 )   185 - 193   2011.2

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    認知症患者の中核症状、周辺症状および日常生活動作能力の関係を明らかにするために、当院入院中の認知症患者58人を対象に向精神薬を使用せずに7日以上経過してから中核症状をMini-Mental State Examination(MMSE)で、周辺症状をNeuropsychiatric Inventory in Nursing Home Version(NPI-NH)で、日常生活動作能力をFunctional Independence Measure(FIM)でそれぞれ評価した。その結果、MMSEとNPI-NHで有意な負の相関(ρ=-0.508:p=0.000)、MMSEとFIMで有意な正の相関(ρ=0.550:p=0.000)、NPI-NHとFIMで有意な負の相関(ρ=-0.353:p=0.007)が得られた。中核症状が軽度な患者は周辺症状も軽度であり、さらに日常生活動作の水準が高いことが示された。(著者抄録)

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  • PETを用いた新規抗精神病薬blonanserinの評価

    TATENO AMANE

    臨床精神薬理   14 ( 2 )   334 - 341   2011.2

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    外傷後、健忘が遷延した48歳女性症例について検討した。注意や意識は保たれているが、短期記憶障害が顕著であった。CT・MRIに異常所見はみられなかった。作動性記憶課題の機能的磁気共鳴画像法(fMRI)を施行したところ、左下前頭回、両側海馬、左前頭葉極において、健常群よりも有意な賦活低下を認めた。COGNISTAT認知機能検査において、記銘力障害が確認された。器質性健忘症候群と考えられた。心理学的認知機能評価に加え、fMRI施行時の脳機能の変化を検証することが器質性精神疾患の補助診断に有用であることが示唆された。

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  • 精神療法の有効性の確立と普及に関する研究「うつ病に対する認知行動療法の効果研究」

    中川敦夫, 大野裕, 藤澤大介, 菊地俊暁, 佐渡充洋, 中川ゆう子, 満田大, 菊地彩, 岩下覚, 田島美幸, 大久保善朗, 館野周, 川島義高, 八幡憲明

    精神療法の有効性の確立と普及に関する研究 平成22年度 総括・分担研究報告書   14 - 20   2011

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  • Effects of caffeine on attentional networks in healthy individuals: A pharmacological fMRI study Reviewed

    Yumiko Ikeda, Michihiko Koeda, Woochan Kim, Noriaki Yahata, Hidehiko Takahashi, Amane Tateno, Yoshiro Okubo, Hidenori Suzuki

    NEUROSCIENCE RESEARCH   71   E174 - E174   2011

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    DOI: 10.1016/j.neures.2011.07.754

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  • 認知症患者の中核症状,周辺症状及び日常生活動作能力の関係について

    寺西美佳, 栗田征武, 西野敏, 武吉健児, 沼田由紀夫, 佐藤忠宏, 中畑則道, 舘野周, 大久保善朗

    総合病院精神医学   22 ( Supplement )   S.157   2010.11

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  • Stroop課題関連の脳活動に対するcaffeineの効果―fMRlによるドーピング効果の検出―

    金禹瑣, 池田裕美子, 肥田道彦, 高橋英彦, 舘野周, 鈴木秀典, 大久保善朗

    日本生物学的精神医学会誌   21 ( Supplement )   101   2010.10

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  • IATを用いた精神疾患に対する差別的態度の評価 医学生を対象として

    奈古 利恵, 西堀 瑛美, 森山 まどか, 安藤 玲奈, 大森 中, 川島 義高, 舘野 周, 大久保 善朗, 井出野 尚, 高橋 英彦, 竹村 和久

    日本医科大学医学会雑誌   6 ( 4 )   233 - 233   2010.10

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  • IATを用いた精神疾患に対する差別的態度の評価 医学生を対象として

    奈古 利恵, 西堀 瑛美, 森山 まどか, 安藤 玲奈, 大森 中, 川島 義高, 井出野 尚, 高橋 英彦, 舘野 周, 竹村 和久, 大久保 善朗

    医学教育   41 ( Suppl. )   193 - 193   2010.7

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  • 大学生のメンタルヘルスの特徴 大学病院精神科外来統計から

    小泉 公平, 西條 朋行, 舘野 周, 野村 俊明, 大久保 善朗

    日本社会精神医学会雑誌   19 ( 1 )   116 - 116   2010.7

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  • 医学生を対象とする精神障害に関するチュートリアル教育の試み 精神障害に関する知識と偏見

    伊藤 滋朗, 舘野 周, 野村 俊明, 大久保 善朗

    日本社会精神医学会雑誌   19 ( 1 )   97 - 98   2010.7

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  • H2ブロッカーlafutidineによる術後せん妄

    上田 諭, 肥田 道彦, 舘野 周, 大久保 善朗

    老年精神医学雑誌   21 ( 増刊II )   158 - 158   2010.6

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  • 医学生・研修医における精神疾患への態度 教育・BSL・研修前後の変化についての検討

    大森 中, 川島 義高, 舘野 周, 井出野 尚, 高橋 英彦, 竹村 和久, 大久保 善朗

    精神神経学雑誌   ( 2010特別 )   S - 208   2010.5

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  • 高齢者で初発の躁病エピソードを呈した双極I型障害に関する臨床的検討

    石井 辰弥, 小須田 茂美, 金 禹瑣, 朝山 健太郎, 一宮 哲哉, 舘野 周, 大久保 善朗

    精神神経学雑誌   ( 2010特別 )   S - 191   2010.5

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  • 抗うつ薬による脳内ノルエピネフリントランスポーター占有率に関するPET研究

    SEKINE MIZUHO, ARAKAWA RYOSUKE, OKUMURA MASANORI, ICHIMIYA TETSUYA, TATENO AMANE, SAITO TAKUYA, ITO HIROSHI, SUHARA TETSUYA, OKUBO YOSHIRO

    精神薬療研究年報   13 ( 42 )   25 - 26   2010.3

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    Positron Emission Tomography(PET)は標識化合物の種類により受容体、トランスポーター、合成能等のモノアミン神経系機能評価やアミロイド、P糖タンパクなどを計測できる。特異結合部位での受容体密度を反映するとされる結合能(BP)を指標にして「受容体占有率(%)=(服薬前BP-服薬後BP)/(服薬前BP)×100」を求めることで、抗精神病薬や抗うつ薬の薬効、至適用量、薬理学的特性、脳内動態の経時的変化、脳内移行性などの評価が行われている。これらの知見、特に受容体占有率に基づく至適用量設定は、我が国でも薬剤開発のPhase IやPhase II試験に利用されるようになっている。今後はマイクロドーズ臨床試験などへの利用も期待されている。本稿では、PETの臨床開発への利用と今後の可能性についてこれまでの知見を踏まえて述べたい。(著者抄録)

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  • 脳機能画像によるこころの科学

    藤澤 洋輔, 野守 美千子, 神山 貴弘, 舘野 周, 八幡 憲明, 大久保 善朗

    日本医科大学医学会雑誌   6 ( 1 )   50 - 51   2010.2

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  • 精神療法の実施方法と有効性に関する研究 うつ病に対する認知行動療法の効果研究

    大野裕, 藤澤大介, 中川敦夫, 菊地俊暁, 佐渡充洋, 中川ゆう子, 満田大, 菊地彩, 岩下覚, 田村法子, 腰みさき, 田島美幸, 大久保善朗, 館野周, 川島義高, 八幡憲明, 米本直裕

    精神療法の実施方法と有効性に関する研究 平成19-21年度 総合研究報告書   17 - 21   2010

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  • 精神療法の実施方法と有効性に関する研究 認知行動療法などの精神療法の効果に関する研究「うつ病に対する認知行動療法の効果研究」

    大野裕, 藤澤大介, 中川敦夫, 菊地俊暁, 佐渡充洋, 中川ゆう子, 満田大, 菊地彩, 岩下覚, 田村法子, 腰みさき, 田島美幸, 大久保善朗, 館野周, 川島義高, 八幡憲明, 米本直裕

    精神療法の実施方法と有効性に関する研究 平成21年度 総括・分担研究報告書   17 - 19   2010

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  • Dose-finding study of blonanserin based on striatal and extrastriatal dopamine D-2 receptor occupancy in patients with schizophrenia

    A. Tateno, R. Arakawa, M. Okumura, H. Fukuta, K. Ishihara, S. Kumita, Y. Okubo

    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY   13   107 - 107   2010

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  • 【分子イメージングの最前線】 分子イメージングによる向精神薬の薬効評価

    舘野 周, 大久保 善朗

    PET Journal   ( 8 )   33 - 34   2009.12

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  • 精神科クリニカルクラークシップの現状と問題点

    齊藤 卓弥, 舘野 周, 西條 朋行, 大久保 善朗

    医学教育   40 ( Suppl. )   80 - 80   2009.7

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  • 総合病院精神科ではDLB患者を診察する機会が増えている?

    下田 健吾, 舘野 周, 木村 真人, 大久保 善朗

    老年精神医学雑誌   20 ( 増刊II )   133 - 133   2009.6

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  • 精神科Bed side learningの現状と問題点

    齊藤 卓弥, 舘野 周, 西條 朋行, 大久保 善朗

    精神神経学雑誌   ( 2009特別 )   S - 506   2009.5

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  • 精神科外来統計からみた大学生のメンタルヘルス

    小泉 公平, 西條 朋行, 舘野 周, 野村 俊明, 大久保 善朗

    精神神経学雑誌   ( 2009特別 )   S - 291   2009.5

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  • 精神療法の実施方法と有効性に関する研究 うつ病に対する認知行動療法の効果研究

    大野裕, 藤澤大介, 中川敦夫, 佐渡充洋, 菊地俊暁, 中川ゆう子, 岩下覚, 杉本彩, 田村法子, 腰みさき, 田島美幸, 大久保善朗, 舘野周, 川島義高, 光井和馬, 八幡憲明, 米本直裕

    精神療法の実施方法と有効性に関する研究 平成20年度 総括・分担研究報告書   13 - 15   2009

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  • Placebo-induced modulation of the human emotional system: an fMRI study Reviewed

    Noriaki Yahata, Yoshitoshi Shingai, Amane Tateno, Hidenori Suzuki, Yoshiro Okubo

    NEUROSCIENCE RESEARCH   65   S229 - S229   2009

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    DOI: 10.1016/j.neures.2009.09.1286

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  • 【アリピプラゾールの臨床】 アリピプラゾールの薬理 Abi-DarghamのPET研究から

    舘野 周, 大久保 善朗

    精神科   13 ( 5 )   401 - 405   2008.11

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  • Pharmacological profile of aripiprazole: new information obtained from Abi-Dargham's PET study

    舘野 周, 大久保 善朗

    Psychiatry   13 ( 5 )   401 - 405   2008.11

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  • 解離症状下での自殺企図及び自傷行為 救命救急センターに搬送された9症例

    川島 義高, 伊藤 敬雄, 舘野 周, 下田 健吾, 鈴木 博子, 山本 正浩, 池森 紀夫, 大久保 善朗

    日本社会精神医学会雑誌   17 ( 1 )   134 - 134   2008.7

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  • 児童精神科医の不足と遠隔診療の可能性

    河嶌 譲, 齊藤 卓弥, 舘野 周, 成重 竜一郎, 御供 正明, 佐藤 忠宏, 大久保 善朗

    精神神経学雑誌   ( 2008特別 )   S - 183   2008.5

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  • Oral pain

    舘野 周, 大久保 善朗

    Japanese journal of clinical psychiatry   37 ( 1 )   33 - 39   2008.1

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  • 精神療法の実施方法と有効性に関する研究 認知行動療法などの精神療法の効果に関する研究「うつ病に対する認知行動療法の効果研究」

    大野裕, 藤澤大介, 佐渡充洋, 中川敦夫, 菊地俊暁, 腰みさき, 田島美幸, 杉本彩, 宗未来, 田村法子, 中川ゆうこ, 花岡素美, 朴順禮, 古谷真理子, 山口洋介, 渡邉義信, 大久保善朗, 舘野周, 川島義高, 光井和馬, 八幡憲明

    精神療法の実施方法と有効性に関する研究 平成19年度 総括・分担研究報告書   17 - 21   2008

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  • vbSEEを用いた機能画像と形態画像の画像統合

    水村 直, 相馬 努, 天野 康雄, 石原 圭一, 福嶋 善光, 椎葉 真人, 山口 英宣, 汲田 伸一郎, 舘野 周, 大久保 善朗

    核医学   44 ( 3 )   313 - 313   2007.10

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  • Consultation-liaison psychiatry for the elderly

    舘野 周, 澤谷 篤, 大久保 善朗

    Japanese journal of clinical psychiatry   36 ( 6 )   749 - 753   2007.6

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  • コンサルテーション・リエゾンサービスによるせん妄への早期介入 日本医科大学附属病院での取り組み

    澤谷 篤, 小川 耕平, 山本 正浩, 川島 義高, 舘野 周, 伊藤 敬雄, 西川 律子, 大久保 善朗

    精神神経学雑誌   ( 2007特別 )   S257 - S257   2007.5

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  • 【双極性障害 双極性概念の拡大と治療法の発展】 双極性障害の最近の脳画像研究

    舘野 周, 大久保 善朗, 須原 哲也

    精神科治療学   20 ( 12 )   1263 - 1271   2005.12

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    双極性障害では,モノアミン,前頭-線条-視床経路,細胞内情報伝達系の異常が推測され,これまでの画像研究結果もこれを支持しているが,個々の結果は一致しないことも多い.近年の画像診断技術の進歩が,脳内の変化のより詳細なin vivoでの評価を可能とした.陽電子放出断層撮影(PET)研究では,病相や治療の代謝への影響や,セロトニン受容体・ドーパミン受容体・トランスポーターのトレーサー開発により神経伝達系の研究が行われている.磁気共鳴イメージング(MRI)研究では,形態変化・神経化学物質の解析による細胞内情報伝達系やlithiumの神経保護作用・神経線維についての研究が行われている.近赤外線スペクトロスコピー(NIRS)研究では,まだ報告が少なくこれからの成果が期待される.脳画像研究を中心として臨床症状,薬理学研究,分子遺伝学研究などが結びつくことで,双極性障害の病態解明,鑑別診断,治療効果予測,新規治療法の開発などが今後期待される(著者抄録)

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  • アルツハイマー型痴呆における脳血流所見の推移

    長尾 毅彦, 根本 清貴, 水村 直, 黄田 常嘉, 大山 雅史, 飯塚 友道, 舘野 周, 平井 平伊, 松田 博史, 本間 昭, 片山 泰朗, 横地 正之

    臨床神経学   45 ( 12 )   1165 - 1165   2005.12

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  • 脳血流SPECTを用いた早期アルツハイマー型痴呆の予後予測

    根本 清貴, 石渡 明子, 黄田 常嘉, 木村 通宏, 長尾 毅彦, 舘野 周, 久慈 一英, 水村 直, 松田 博史, 新井 平伊, 本間 昭

    核医学   42 ( 3 )   358 - 358   2005.9

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  • 無けいれん性通電療法が奏効した器質性精神障害の2症例

    福田 一, 舘野 周, 一宮 哲哉, 大久保 善朗

    精神神経学雑誌   107 ( 9 )   1005 - 1005   2005.9

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  • 超高齢者における精神障害について うつ病の特徴とその治療

    舘野 周, 伊藤 敬雄, 新井 麻紀, 青木 要子, 大久保 善朗

    精神神経学雑誌   ( 2005特別 )   S217 - S217   2005.5

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  • 抗精神病薬による維持療法時のドーパミンD2受容体占有率の検討

    荒川 亮介, 大久保 善朗, 一宮 哲哉, 舘野 周, 西條 朋行, 伊藤 敬雄, 高野 晶寛, 安野 史彦, 須原 哲也

    精神薬療研究年報   ( 37 )   7 - 12   2005.3

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    [11C]FLB457を用いたPET検査により,抗精神病薬維持療法時の側頭皮質ドーパミンD2受容体占有率を明らかにした.抗精神病薬単剤で治療を受けている統合失調症患者10例を対象とした.側頭皮質におけるドーパミンD2受容体占有率は最小0%,最大84.3%で,平均59.1%であった.維持療法中の7例は,D2受容体占有率は最小30.8%,最大84.3%で,平均61.9%であった.維持療法中の7例中5例が70%以下の占有率であった.sulpirideについて,70〜80%をD2至適占有率として至適用量を推定すると,およそ400〜700mg/日となった.維持療法時では急性期と同様の高い占有率を必要としない可能性があり,さらなる検討が必要であることが示唆された

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  • Treatment of Psychiatric Disorder following Traumatic Brain Injury

    TATENO AMANE, OKUBO YOSHIRO

    日本医科大学医学会雑誌   1 ( 1 )   17 - 20   2005.2

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    Psychiatric disorders following traumatic brain injury (TBI) have negative influence on the recovery from TBI (e.g., they worsen the effect of rehabilitation, psychosocial function, activity of daily living, quality of life, relations with family members, etc.). Although psychiatric disorders are frequent complications of TBI (e.g., mood disorder 6&amp;sim;77%, anxiety disorder 11&amp;sim;70%, psychotic disorder 2&amp;sim;20%, and problematic behavior 11&amp;sim;90%), most of them are misdiagnosed and not treated adequately. Treatment of psychiatric disorder following TBI is not different from treatment of primary psychiatric disorder. TBI patients, however, are more sensitive to the side effects of medications, and therefore we should treat them by (1) starting low and going slow, (2) setting an adequate therapeutic trail with regard to dosage and duration of treatment, (3) frequent assessment during the treatment period, and (4) paying attention to adverse effects and drug interactions. Since psychiatric disorders may worsen the recovery process from TBI, successful treatment is especially important for TBI patients. It is essential for clinicians to be aware of any psychiatric disorders following TBI and to treat them properly.

    DOI: 10.1272/manms.1.17

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  • 臨床医のために 頭部外傷後精神障害の治療について

    舘野 周, 大久保 善朗

    日本医科大学医学会雑誌   1 ( 1 )   17 - 20   2005.2

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  • 症例 辺縁系脳炎後の緊張病様症状に無痙攣性通電療法が著効した1症例

    福田 一, 舘野 周, 伊藤 敬雄

    精神科   6 ( 1 )   61 - 64   2005.1

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  • 辺縁系脳炎後の緊張病様症状に無痙攣性通電療法が著効した1症例

    福田 一, 舘野 周, 伊藤 敬雄, 一宮 哲哉, 朝山 健太郎, 大久保 善朗

    精神科   6 ( 1 )   61 - 64   2005.1

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    辺縁系脳炎(LE)によりひき起こされた器質性精神障害に無痙攣性通電療法(m-ECT)が著効した症例(14歳女性)を報告した.患者は統合失調症を疑われた後にLEと診断され,脳炎治療後も続く緊張病様症状に対してm-ECTが効果的であった.精神疾患と判断することで重篤な身体症状,またはその徴候が見逃されることもあり,患者の生命予後を重視する際には除外されない身体疾患を積極的に疑い,診断を進めることが適切と考える.本症例のような経過・検査所見を示す症例に対しては,稀ではあるがARLE-MR(N)を含めLEの可能性を検討することは意義がある.また,脳炎罹患後に意識障害や身体症状が改善されて精神症状が残存する症例や,器質性精神障害としての緊張病様症状を呈する症例において,m-ECTは有効な治療法の一つと考えられた

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    Other Link: http://search.jamas.or.jp/link/ui/2005165922

  • 口腔内疼痛性障害の薬物療法および脳血流評価

    荒川 亮介, 舘野 周, 水村 直, 岡田 智雄, 石井 隆資, 大津 光寛, 長谷川 功, 苅部 洋行, 大久保 善朗

    日本歯科心身医学会雑誌   19 ( 1〜2 )   112 - 112   2004.12

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  • 介護ストレス以外の高齢者虐待の原因--ADLが自立していた4症例報告からの検討

    伊藤 敬雄, 葉田 道雄, 舘野 周

    臨床精神医学   33 ( 12 )   1617 - 1622   2004.12

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    Other Link: http://search.jamas.or.jp/link/ui/2005070226

  • 非定型抗精神病薬投与中clonazepam減量に伴いParkinson症候群を呈した1症例

    NARISHIGE RYUICHIRO, TATENO AMANE, OKUBO YOSHIRO

    精神医学   46 ( 10 )   1113 - 1115   2004.10

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    統合失調症急性期治療において非定型抗精神病薬であるリスペリドンに加え,クロナゼパムを使用し,症状軽快後にクロナゼパムを減量したところ,パーキンソン症候群を呈した症例(26歳女性)を報告した.クロナゼパムは統合失調症急性期治療において興奮,焦燥に対して有効な薬剤であり,抗精神病薬による錐体外路症状が比較的出現しやすい統合失調症初回エピソードにおいては錐体外路症状の予防という点でも有効である可能性がある.その一方で急性期治療の後クロナゼパムの減量を考える際には,減量によりパーキンソン症候群が発現する危険性を考慮する必用があると思われた

    DOI: 10.11477/mf.1405100571

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  • A Study of Suicide Attempters who Admitted to the Critical Care and Emergency Center

    SEKINE Mizuho, SUZUKI Hiroko, TAKEZAWA Kenji, TATENO Amane, ASAYAMA Kentaro, OKUBO Yoshiro

    総合病院精神医学 = Japanese journal of general hospital psychiatry   16 ( 3 )   257 - 263   2004.9

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  • 【自殺企図患者の動機と心理社会的特徴】 救命救急センターに搬送された自殺未遂症例の検討

    関根 瑞保, 鈴木 博子, 竹沢 健司, 舘野 周, 朝山 健太郎, 大久保 善朗

    総合病院精神医学   16 ( 3 )   257 - 263   2004.9

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    2003年1月〜10月に大学病院高度救命救急センターに自殺企図で搬送され未遂に終わった患者のうち,精神科医が関与した111例を対象に実態を調査し,特に対人関係の問題を自殺企図の動機とした未遂症例(38.4%)について検討した.その結果,IDC-10でF4カテゴリーに分類される症例が最も多かった.企図手段では,薬物・毒物によるものが最も多く,自殺企図の動機では,家族や恋人とのトラブルなどによる対人関係の問題を動機とするものが最も多かった.対人関係の問題を動機とする症例に着目すると,F4カテゴリーに分類されるものが57.1%を占め,そのほとんどがF43.2:適応障害と診断された.対人関係の問題などの些細な心因を動機とする衝動的な自殺企図の背景には,性格的な偏り,人格障害を伴っている可能性があったが,救命救急センターの短期間の入院経過では十分な情報が得られず,適応障害のみと診断された症例が多く含まれていた可能性がある

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  • アルツハイマー型痴呆の脳血流SPECTによる短期予後予測

    根本 清貴, 飯塚 友道, 黄田 常嘉, 長尾 毅彦, 舘野 周, 水村 直, 松田 博史, 新井 平伊, 朝田 隆, 本間 昭

    核医学   41 ( 3 )   347 - 347   2004.9

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  • eZISを用いたアルツハイマー型痴呆症例の多施設間共有データ解析

    水村 直, 新井 平伊, 飯塚 友道, 黄田 常嘉, 舘野 周, 長尾 毅彦, 根本 清貴, 本間 昭, 松田 博史

    核医学   41 ( 3 )   346 - 346   2004.9

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  • 自殺未遂症例における自殺企図の動機

    関根 瑞保, 鈴木 博子, 竹澤 健司, 舘野 周, 朝山 健太郎, 大久保 善朗

    総合病院精神医学   15 ( Suppl. )   S122 - S122   2003.11

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  • 頻回に一過性健忘を呈した1症例

    田邊 綾, 下田 健吾, 舘野 周, 村田 雄一, 遠藤 俊吉

    東京精神医学会誌   19 ( 1 )   28 - 28   2001.12

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  • 血管性うつ病における123I-IMP SPECT所見 非血管性うつ病との縦断的比較

    下田 健吾, 木村 真人, 森 隆夫, 葉田 道雄, 鈴木 博子, 舘野 周, 遠藤 俊吉

    脳21   4 ( 4 )   435 - 435   2001.10

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  • セネストパチーの123I-IMP SPECT所見 うつ病との比較

    舘野 周, 木村 真人, 下田 健吾, 葉田 道雄, 森 隆夫, 鈴木 博子, 村田 雄一, 遠藤 俊吉, 水村 直, 佐藤 田鶴子

    脳と精神の医学   12 ( 2 )   127 - 132   2001.6

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    口腔内異常感覚を訴える狭義のセネストパチー(CP)8例(A群)と,大鬱病を伴なう広義のCP5例(B群),大鬱病9例(C群)を対象に検討した.C群と比べA群では左右視床と右前部帯状回で有意に高い局所脳血流量(rCBF)を示し,B群では左視床で高いrCBFを示した.A,B群間にはrCBFの有意差を認める部位はなく,左右視床と右前部帯状回の機能変化がCP症状の出現に関与している可能性が示唆された.狭義及び広義のCPに認められた視床領域,特に左視床の所見はCP症状と密接に関連していると考えられたが,今後,正常対照群との検討が必要である

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  • 一過性てんかん性健忘(TEA)の1例 臨床経過と脳波所見との関連

    田邊 綾, 下田 健吾, 木村 真人, 森 隆夫, 鈴木 博子, 村田 雄一, 舘野 周, 遠藤 俊吉

    臨床神経生理学   29 ( 2 )   121 - 121   2001.4

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  • セネストパチーの^<123>I-IMP SPECT所見-うつ病との比較-

    館野周

    脳と精神医学   12   127 - 131   2001

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  • うつ病の123IMP-SPECT所見と事象関連電位P300について

    下田 健吾, 木村 真人, 舘野 周, 森 隆夫, 鈴木 博子, 遠藤 俊吉

    脳波と筋電図   27 ( 2 )   200 - 200   1999.4

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  • うつ病における123IMP-SPECT所見と事象関連電位P300について

    下田 健吾, 木村 真人, 舘野 周, 森 隆夫, 鈴木 博子, 遠藤 俊吉

    脳波と筋電図   27 ( 1 )   70 - 70   1999.2

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  • 高齢うつ病者の塩酸bifemelane追加投与後の臨床効果とSPECT所見の関連について

    舘野 周, 木村 真人, 下田 健吾, 葉田 道雄, 鈴木 博子, 森 隆夫, 遠藤 俊吉, 水村 直

    東京精神医学会誌   16 ( 1 )   95 - 95   1998.12

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  • ERPs study in 3 cases of shizophrenic patients with Capgras syndrome.

    HADA MICHIO, KIMURA MAHITO, ENDO SHUNKICHI, SHIMODA KENGO, MORI TAKAO, SATO AKIKO, TATENO AMANE, SUZUKI HIROKO

    臨床脳波   38 ( 5 )   353 - 356   1996.5

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    高齢者虐待4例を報告した.被害者はADLは自立していたが家族に依存せざるを得ない生活状況にあった.虐待加害者の言動と態度により緊張感,恐怖感,うつ症状,身体症状の悪化を認めたが理解者の死去や不在のため相談できず,また,責任感の強い性格傾向と抑圧された感情から虐待を報告できなかった.加害者は同居の主介護者で身体的虐待2例の加害者は精神的脆弱性を有していた.弱者・依存者となった高齢者に対し,過去から蓄積された緊密関係,老親子間の未解決の葛藤と歪んだ相関関係から,蔑視意識,嫌悪感,差別意識が強まり,家族内において高齢者の存在は空虚化・希薄化した.このため加害者の虐待認識の欠如と家族成員の虐待に対する問題意識の欠如から,家庭内に加害者は拡大していき,結果として虐待の発見が困難になったと考えられた.以上より,虐待の原因として介護ストレス以外の要因が考えられた

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  • 錯乱状態に始まり,経過中に悪性症候群を併発した脳炎の1症例

    舘野 周

    東京精神医学会誌   13 ( 1 )   71 - 71   1995.12

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Presentations

  • 出産直後に発症した重症うつ病に対し、ECTにて加療したのち退院後のサポート体制を策定した1例

    大矢智之, 増岡孝浩, 大髙靖史, 坂寄健, 朝山健太郎, 舘野周, 大久保善朗

    第114回東京精神医学会  2018.11 

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Research Projects

  • Elucidation of impulse control neural circuits involved in suicide attempts and biological indicators for prevention of repeat attempts

    Grant number:24K10745  2024.4 - 2028.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Grant amount:\4420000 ( Direct Cost: \3400000 、 Indirect Cost:\1020000 )

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  • Pathophysiological studies on the relationship between neurodegenerative disease pathology and treatment responsiveness in geriatric depression

    Grant number:24K10744  2024.4 - 2027.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

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  • [18F]PM-PBB3を用いたタウイメージングによるパルス波ECTの認知機能への影響研究

    Grant number:24K10692  2024.4 - 2027.3

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    坂寄 健, 野上 毅, 荒川 亮介, 舘野 周

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    Grant amount:\4550000 ( Direct Cost: \3500000 、 Indirect Cost:\1050000 )

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  • Drug repositioning of the analgesic drug tramadol using central nervous system PET imaging

    Grant number:24K10691  2024.4 - 2027.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Grant amount:\4550000 ( Direct Cost: \3500000 、 Indirect Cost:\1050000 )

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  • An attempt to elucidate the neurological basis of empathy and depression among medical professionals

    Grant number:23K09609  2023.4 - 2026.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    Eisho Yoshikawa, Michihiko Koeda, Amane Tateno, Nozumi Sukigara

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    Grant amount:\2990000 ( Direct Cost: \2300000 、 Indirect Cost:\690000 )

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  • タウ蛋白PETイメージングからみた老年期うつ病の治療反応性の解明

    Grant number:20K07981  2020.4 - 2023.3

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    荒川 亮介, 大久保 善朗, 舘野 周

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    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

    高齢者のうつ病治療においては、通常の薬物療法に反応が乏しいことがしばしば見受けられる。その背景に、アルツハイマー型認知症をはじめとする器質性疾患の前駆症状としてのうつ状態、もしくはその合併があるとする報告があるが、臨床症状からの判断だけでは、その鑑別や確認を行うのは困難であることが多い。アルツハイマー型認知症の病態生理の代表的なものとして、老人斑(アミロイドβ)と神経原繊維変化(タウ蛋白)があげられる。アミロイドβについては、PETにより生体内において脳内集積を評価出来るようになっており、アルツハイマー型認知症で認められる病理が高齢者のうつ病発症に関与している可能性が報告されている。一方、アルツハイマー型認知症の認知機能障害の程度は、タウ蛋白の局所集積と関連するという報告があり、タウ蛋白による局所神経細胞脱落が精神・神経症状の出現、進行に強く関与していることが示唆されている。近年、タウ蛋白を対象としたPETリガンドの開発が盛んに行われているが、従来の[11C]PBB3等のPETリガンドについては、脳内のタウ蛋白の定量に一定の制限があることが指摘されている。これらの問題点を改良した[18F]PM-PBB3が開発され、臨床応用が進められているところである。
    本年度は、6名の寛解期にあるうつ病患者に対して、[18F]PM-PBB3を用いたPET測定を行い、6名全てでタウ蛋白の集積は認められなかった。昨年度の結果と合わせると、1名のみが陽性で、残り7名は陰性と判断された。このことから、同様の寛解期にあるうつ病患者においても、その脳内のタウ蛋白の集積に大きな差があることが判明した。

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  • 薬理学的脳機能画像法と経頭蓋直流電気刺激法による痛みの共感に関する神経基盤の解明

    Grant number:19K07809  2019.4 - 2023.3

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    池田 裕美子, 舘野 周, 肥田 道彦

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    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

    共感は、重要な社会的認知機能の1つである。ヒトは、他者が喜びや悲しみといった情動および痛みのような感覚をどのように感じているかを理解することができる。近年、痛みの共感の障害が、神経障害性疼痛を始めとする様々な疾患で現れることが報告され、痛みの共感の神経基盤を解明する研究が活発に行われている。これまで痛みの共感に関する神経画像研究が行われているが、痛みの共感の神経基盤について一貫した見解は得られていない。本研究の目的は、薬理学的手法を使って、痛みの共感に関わる脳内ネットワークおよびそのネットワークを修飾する神経伝達物質を特定することである。
    本年度は、痛みの共感で活動する脳領域を特定するために、健常成人を対象としたfMRI検査によって取得したデータを使用して脳画像解析を行った。fMRI検査では、被験者に他者が痛みを伴うような傷害を受けている画像と対照画像を呈示した。脳画像解析では、対照画像を見ている間の脳活動と比較して、他者が痛みを伴うような傷害を受けている画像を見ている間の脳活動が有意に増加している脳領域を、痛みの共感で活動する脳領域として評価した。その結果、痛みの共感において、島皮質、前部帯状回、下頭頂小葉の活動がみられた。さらに、共感は、他者の立場に立って他者の思考や感情を推測する認知的共感と、他者の感情状態を共有する情動的共感に分類され、それぞれ異なる神経基盤が示唆されていることから、痛みに関連する認知的共感および情動的共感の脳活動を評価した。痛みの認知的共感において、側頭頭頂接合部および上側頭溝の有意な活動がみられた。痛みの情動的共感においては、下前頭回の有意な活動がみられた。これらの痛みの共感における脳活動領域は、先行研究の結果と一致していた。現在、これらの結果を踏まえて、薬理学的手法によって修飾される脳領域および神経伝達物質を特定する脳画像解析を進めている。

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  • The role of tau protein and 5-HT1B receptor in the amyloid associated depression by positron emission tomography

    Grant number:19K08029  2019.4 - 2022.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    Tateno Amane

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    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

    The number of patients who completed the PET examinations was less than half of the originally planned number (15) due to a one-year interruption in both subject recruitment and PET examinations caused by the spread of coronary infection. Tau PET imaging was performed in 8 subjects (6 females and 2 males, mean age 74.1 years), and 5-HT1B receptor PET was also performed in 4 subjects (3 females and 1 male, mean age 69.5 years). Analysis revealed significant tau protein accumulation in the hippocampal region in one patient, and 5-HT1B receptor accumulation in the hippocampal region.
    It was not possible to determine from the present study whether 5-HT1B receptors and tau protein accumulation are related in terms of distribution, density, and degree in the group of patients with amyloid-related depression.

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  • Clarification of the impairment of default mode/functional network due to tau-pathology pathway for Behavior problems of dementia

    Grant number:19K08028  2019.4 - 2022.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

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    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

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  • 非侵襲的脳機能画像法による歯科恐怖症の脳内ネットワークの解明と新たな対応法の開発

    Grant number:17K12063  2017.4 - 2021.3

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    苅部 洋行, 大久保 善朗, 舘野 周, 肥田 道彦

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    Grant amount:\4810000 ( Direct Cost: \3700000 、 Indirect Cost:\1110000 )

    1)歯科聴覚刺激の新規課題に対する脳活動の評価:歯科臨床の場において、歯科恐怖症患者に対する対応法は多種多様である。治療中の聴覚刺激などの不快刺激を軽減するための方策としてはカウント法が頻用されている。しかし、歯科聴覚刺激に対する脳活動の観点から、その効果を検討した研究はみられない。そこで、歯科治療時の不快な聴覚刺激を素材とした心理課題を新たに作成し、課題遂行中の脳活動をfMRIにて評価することとした。
    2)心理テストの施行:被験者10名(女性8名、男性2名)に対して、国際的標準尺度であるDental Fear Survey を用いて歯科恐怖の評価を行い、歯科医師に対する信頼度をDental Beliefs Surveyで、健康関連QOLをMedical Outcome Study 36-Item Short-Form Health Survey (SF-36)で、心理性格特性をSelf-rating Depression ScaleとState Trait Anxiety Inventoryの心理尺度にて評価した。
    3)fMRI検査の実施と自律神経反応の測定:同様の被験者10名に対して、眠らず閉眼安静にすることを指示し、約5分間の安静時の撮像を行った。聴覚刺激課題では、歯科聴覚刺激時、音声刺激時、歯科聴覚刺激+音声刺激時の脳活動をfMRIにて撮像するとともに、自律神経反応の評価として、心臓自律神経系活動と皮膚電気活動を同時計測した。今後はさらに被験者数を増やして、詳細な解析を行っていく予定である。
    4)研究発表:現在までの歯科聴覚刺激に対する研究成果と日本人中学生の歯科医師に対する信頼度の疫学調査の結果が学術論文として国際誌に掲載された。さらに、これらの内容は国際学会にて研究発表を行った。また、国内学会では招待講演にてこれまでの研究成果を紹介した。

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  • 非侵襲的脳機能画像法による歯科恐怖症の脳内ネットワークの解明と新たな対応法の開発

    2017 - 2020

    文部科学省  科学研究費補助金(基盤研究(C)) 

    苅部 洋行

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    Grant type:Competitive

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  • The study for the pathology of delusion and hallucination among geriatric patients by tau imaging

    Grant number:16K10227  2016.4 - 2019.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    Tateno Amane

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    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

    The relationship between tau-protein and psychotic symptoms among non-demented patients who presented late-onset psychotic symptoms was examined by positron emission tomography (PET) with [11C]PBB3. Nine patients and 6 healthy volunteers (2 male and 3 female, average age was 73.5 years old, average MMSE score was 29 point) were participated in the study. The diagnosis of patients (4 male and 5 female, average age was 77.3 years old, average MMSE score was 27.3 point) were following; schizophrenia: 2 patients, delusional disorder: 2 patients, organic mental disorder: 3 patients, depression: 2 patients. PET scan detected significant accumulation of tau-protein in some of patients. However, we could not find the common areas of psychotic symptom where the significant accumulation of tau-protein. Our results indicated the possibility that some of the non-demented patients with geriatric onset of psychotic symptoms were caused by tau-induced neuropathy.

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  • タウイメージングによる老年期幻覚妄想の病態解明研究

    2016 - 2018

    文部科学省  科学研究費補助金(基盤研究(C)) 

    舘野 周

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    Authorship:Principal investigator  Grant type:Competitive

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  • Molecular imaging of amyloid-associated depression

    Grant number:15H04896  2015.4 - 2019.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)  Grant-in-Aid for Scientific Research (B)

    Okubo Yoshiro

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    Grant amount:\17550000 ( Direct Cost: \13500000 、 Indirect Cost:\4050000 )

    We aimed to develop a diagnostic method of depression as a precursor symptom of dementia such as Alzheimer's disease (AD) using novel molecular imaging techniques. First, we conducted a 20-month follow-up survey on patients with mild cognitive impairment and depression. As a result, it was confirmed that there were more cases of transition to dementia in the amyloid positive group. Next, we introduced tau imaging and confirmed that there were cases with strong tau accumulation among depressive patients. Some of these cases appeared to have depression as a precursor to AD and other tauopathy. Furthermore, we found that mild to moderate decline in dopamine transporter was observed in elderly depression, and introduced serotonin 1B receptor imaging as a novel biomarker of depression.

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  • Molecular neuroimaging research of abnormality of default mode network in dementia

    Grant number:15K09844  2015.4 - 2018.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    Koeda Michihiko

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    Grant amount:\4810000 ( Direct Cost: \3700000 、 Indirect Cost:\1110000 )

    Development of new treatments for the early prevention of dementia is a pressing issue for the aging society of Japan. We examined the accumulation of amyloid, considered a risk for dementia, by Positron Emission Tomography. In addition, with the use of functional MRI, we evaluated brain function at resting state in Alzheimer’s disease and depression in the elderly. Based on the results, we verified the associated accumulation of amyloid with brain function at resting state, including the default mode network (DMN). Our results showed that amyloid gradually accumulates in persons at risk of dementia. Further, our results demonstrated that patients with depression have functional impairment in the left parietal lobe, whereas those with Alzheimer’s disease are impaired in the right parietal lobe. From these findings, association between the progressive pathology of dementia and brain function at resting state was revealed.

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  • アミロイド関連うつ病の分子イメージング

    2015 - 2018

    文部科学省  科学研究費補助金(基盤研究(B)) 

    大久保 善朗

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    Grant type:Competitive

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  • 認知症におけるデフォルトモードネットワーク異常に関する分子イメージング研究

    2015 - 2017

    文部科学省  科学研究費補助金(基盤研究(C)) 

    肥田 道彦

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  • Development of a psychosocial intervention program for supporting older people

    Grant number:26590165  2014.4 - 2018.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research  Grant-in-Aid for Challenging Exploratory Research

    Kashimura Masami, ISHIWATA Akiko, NOGAMI Akane, TATENO Amane, SUKIGARA Nozomi, KAWASHIMA Yoshitaka, ARAKI Maho, KAWANISHI Tomoya, HARA Yuko, YAMASHITA Mari, KITAMURA Shin

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    Grant amount:\3120000 ( Direct Cost: \2400000 、 Indirect Cost:\720000 )

    The aim of this study was to develop two psychosocial intervention programs (for older people with mild cognitive impairment and mild dementia and family caregivers with demented relatives), and to examine the safety and effectiveness. In this study, we were able to develop two programs and to conduct two intervention studies for the 15 elderly and 10 caregivers. As a result, the interventions enabled them to improve their depressive mood and quality of life. Additionally, there was no adverse event during the interventions and the participant’s satisfaction levels of two programs were high. Finally, we were able to contact with two researchers in the United Kingdom who developed a psychosocial program for family caregivers with demented relatives, called “START”, which we adopted it as our intervention for family caregivers, and to receive their guidance and to build forward-looking relationships with them for our future collaborative works.

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  • Neural correlates of dental fear in the cerebral response to dental sounds: An fMRI study

    Grant number:25463266  2013.4 - 2017.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    KARIBE HIROYUKI, NAKA KYOKO

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    Grant amount:\5070000 ( Direct Cost: \3900000 、 Indirect Cost:\1170000 )

    The present study utilized functional magnetic resonance imaging to assess the relationships between cerebral activation in response to auditory stimuli and levels of dental fear and trait anxiety. We found that activation in the left posterior superior temporal gyrus and bilateral precentral gyri positively correlated with dental fear scores in all participants. In contrast, activation in the right middle temporal gyrus, the left inferior frontal gyrus, and the right insula positively correlated with trait anxiety scores in all participants. This difference in activation may indicate some differential level of processing for both types of anxious behaviors.

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  • 非侵襲的脳機能画像法を用いた歯科恐怖症に対する効果的な認知行動技法の定量的評価

    2013 - 2016

    文部科学省  科学研究費補助金(基盤研究(C)) 

    苅部 洋行

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  • The dopamine transporter PET study clarify the mechanism of delusion and develop the objective evaluation method for delusion.

    Grant number:25461788  2013 - 2015

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Tateno Amane, OKUBO YOSHIRO

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\5070000 ( Direct Cost: \3900000 、 Indirect Cost:\1170000 )

    The role of dopamine transporter (DAT) function in the delusion and hallucination was examined by DAT positron emission tomography (PET). Seventeen geriatric patients with delusional disorder, 8 geriatric patients with schizophrenia, 12 geriatric healthy subjects, 2 young patients with delusional disorder, 6 young patients with schizophrenia and 9 young healthy controls were participated. DAT binding potential (BP) was examined by DAT-PET to compare the DAT function of each groups. Compared to geriatric healthy controls, geriatric patients with delusional disorder showed significantly lower DAT-BP. These results indicated the possibility that the decreased DAT function takes part in the mechanism of delusional disorder in old age period.

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  • A study on biomarker of dementia of Lewy bodies with dopamine transporter imaging

    Grant number:24591733  2012 - 2014

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    UEDA Satoshi, OKUBO Yoshiro, TATENO Amane

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    Authorship:Collaborating Investigator(s) (not designated on Grant-in-Aid)  Grant type:Competitive

    Grant amount:\5200000 ( Direct Cost: \4000000 、 Indirect Cost:\1200000 )

    It does not appear easy to correctly diagnose patients with dementia with Lewy bodies (DLB). Although there is no definite diagnostic biomarkers for DLB, dopamine transporter (DAT) imaging using PET is considered possibly usuful as one of the strong biomarkers.
    DAT imaging was conducted for patients with depression or parkinsonism, which DLB often accompanies. DAT imaging made it very easy to diagnose DLB among depressive or parkinsonic patients. These findings suggest that DAT imaging using PET may be a clinically useful biomarker for DLB.

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  • Amyloid imaging with PET and florbetapir F18 in geriatric depression

    Grant number:23390292  2011 - 2014

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    YOSHIRO Okubo, SUZUKI Hidenori, TATENO Amane

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    Authorship:Collaborating Investigator(s) (not designated on Grant-in-Aid)  Grant type:Competitive

    Grant amount:\19110000 ( Direct Cost: \14700000 、 Indirect Cost:\4410000 )

    We performed amyloid positron emission tomography (PET) with [18F]florbetapir in patients with Alzheimer's disease (AD), mild cognitive impairment (MCI), and older healthy controls (OHC). A cutoff values for measuring AD-like levels of amyloid for SUVR was well differentially diagnosed and clinically defined AD from OHC. We examined patients with MCI with a history of geriatric depression (GD) and OHC to evaluate the effect of beta-amyloid (Aβ) pathology. Compared to patients without Aβ (GD-Aβ), patients with Aβ (GD+Aβ) did not differ in terms of age, cognitive function, severity of depression and ADL, and brain atrophy. But GD+Aβ had significantly older average age at onset of GD. Our results showed that the rate of Aβ positivity was higher in late-onset GD and that onset-age was associated with SUVR, suggesting that the later the onset of GD, the more Aβ pathology affected its onset.

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  • The evaluation of dopaminergic and noradrenargic function of treatment resistant depression by neuromelanin MRI

    Grant number:22591303  2010 - 2012

    Ministry of Education, Culture, Sports, Science and Technology  Grants-in-Aid for Scientific Research(基盤研究(C))  基盤研究(C)

    Amane TATENO, Yoshiro OKUBO

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4550000 ( Direct Cost: \3500000 、 Indirect Cost:\1050000 )

    The role of dopamine and noradrenalin among the patients with depression were evaluated by neuromelanin magnetic resonance imaging (MRI) and dopamine transporter (DAT) positron emission tomography (PET). The signal of neuromelanin MRI of patients with depression was significantly lower in locus coeruleus and substantia nigra pars compacta than healthy controls. The availability of dopamine transporter in striatum of patients with depressed phase was significantly lower than healthy controls, however that of patients with remitted phase was comparable with healthy controls. The signal of neuromelanin MRI was significantly correlated with the function of dopamine transporter among healthy controls. In conclusion, patients with depression had lower dopaminergic function and neulomelanin MRI was as useful as DAT PET for the evaluation of dopaminergic function.

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  • Cerebral activation associated with dental fear: An fMRI study

    Grant number:21592666  2009 - 2012

    Ministry of Education, Culture, Sports, Science and Technology  Grants-in-Aid for Scientific Research(基盤研究(C))  基盤研究(C)

    Hiroyuki KARIBE, 八幡 憲明, Yoshiro OKUBO, Hidenori SUZUKI, Amane TATENO, Noriaki YAHATA

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    Authorship:Collaborating Investigator(s) (not designated on Grant-in-Aid)  Grant type:Competitive

    Grant amount:\4550000 ( Direct Cost: \3500000 、 Indirect Cost:\1050000 )

    To better understand the relationship between dental fear and auditory stimuli, we aimed to investigate cerebral activation associated with sounds of dental treatment using fMRI. Our findings suggest that the cerebral activation pattern observed in individuals with dental fear differed from that observed in control individuals. Increased activation in the subcortical region may be associated with the learning and memory of the sounds associated with dental treatment.

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  • Establishing a neuroimaging-based biomarker that aids optimal diagnosis and treatment of mood disorder

    Grant number:20591378  2008 - 2012

    Ministry of Education, Culture, Sports, Science and Technology  Grants-in-Aid for Scientific Research(基盤研究(C))  基盤研究(C)

    Noriaki YAHATA, 大久保 善朗, 鈴木 秀典, 舘野 周

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    Authorship:Collaborating Investigator(s) (not designated on Grant-in-Aid)  Grant type:Competitive

    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

    We aimed to establish a neuroimaging-based biomarker for depression that may help optimizing the treatment of this disorder on an individual basis. We focused on the self-reference task, for which the participants judged whether visually-presented sentences describing adaptive or non-adaptive behaviors in given situations are applicable to the participants themselves. We found that the activity in the medial prefrontal cortex (MPFC) was higher for the patient group when they made judgments on adaptive behaviors, correlating positively with the Hamilton depressive rating scale. We also found that the activity in the MPFC was higher for the healthy control group during their judgments on non-adaptive behaviors, correlating positively with the harm avoidance score in the Temperament and Character Inventory. Collectively, it is suggested that the self-reference task may be a useful state-trait biomarker of mood disorder at the neural network level that may aid diagnosing and determining the kind of treatments for the patients.

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  • Brain structural change in child and adolescent depression

    Grant number:20591423  2008 - 2010

    Ministry of Education, Culture, Sports, Science and Technology  Grants-in-Aid for Scientific Research(基盤研究(C))  基盤研究(C)

    Takuya SAITO, Yoshiro OKUBO, Amane TATENO

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    Authorship:Collaborating Investigator(s) (not designated on Grant-in-Aid)  Grant type:Competitive

    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

    Depression is a major mental health problem in child and adolescent and the prevalence is estimated approximately 5-8% and is gradually increased. However, there is no biological maker for child and adolescent for diagnosis and treatment. To find association between biomarkers and symptoms for child depression is important. 8 major depressive disorder child and age matched non-depressive 7clinical samples are participated in an MRI experiment. Whole-brain analyses were conducted and the results of these analyses were examined for potential relationships with depression severity, Quality of life and General psychopathology.

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  • Molecular imaging of altered dopamine transmission in patients with schizophrenia

    Grant number:19390308  2007 - 2010

    Ministry of Education, Culture, Sports, Science and Technology  Grants-in-Aid for Scientific Research(基盤研究(B))  基盤研究(B)

    Yoshiro OKUBO, 須原 哲也, Takuya SAITO, Amane TATENO, Tetsuya ICHIMIYA, Michihiko KOEDA

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    Authorship:Collaborating Investigator(s) (not designated on Grant-in-Aid)  Grant type:Competitive

    Grant amount:\18330000 ( Direct Cost: \14100000 、 Indirect Cost:\4230000 )

    Using positron emission tomography (PET) and different radioligands, we aimed to elucidate altered dopamine transmission in patients with schizophrenia. Using two different radioligands, [^<11>C]NNC112 and [^<11>C]SCH23390, we measured dopamine D1 receptor binding in patients with chronic schizophrenia and healthy controls. In patients with schizophrenia, the binding potentials of both ligands were significantly lower in the striatum and cortical regions than those of healthy controls. We measured presynaptic dopamine synthesis using PET with L-[β-^<11>C]DOPA and found that patients with schizophrenia showed higher dopamine synthesis in the left caudate nucleus, and that dopaminergic transmission in the thalamus and right temporal cortex might be implicated in the expression of symptoms in schizophrenia. Finally, we performed PET using [^<11>C]PE2I in patients with schizophrenia and healthy subjects to investigate dopamine transporter binding. Dopamine transporter binding in the thalamus of patients with schizophrenia was significantly higher than in control subjects. There were significant correlations between dopamine transporter binding and clinical symptom scores suggesting that altered dopamine transporter binding in the thalamus might be related to the pathophysiology and clinical symptoms of schizophrenia.

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  • The prospective study in the relationship between recurrence or treatment-resistance of depression and vulnerability of brain using brain imaging and neurotrophic factor.

    Grant number:19591379  2007 - 2009

    Ministry of Education, Culture, Sports, Science and Technology  Grants-in-Aid for Scientific Research(基盤研究(C))  基盤研究(C)

    Amane TATENO, 水村 直, Yoshiro OKUBO, Hidenori SUZUKI, Sunao MIZUMURA

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4550000 ( Direct Cost: \3500000 、 Indirect Cost:\1050000 )

    We investigated patients with depression using brain morphometry and functional MRI. Patients with depression at the beginning of the treatment showed significantly smaller gray matter volume in anterior cinglate, ventromedial temporal, ventromedial frontal, and caudate head than healthy controls. We made the task for fMRI to evaluate self-esteem and dysfunctional attitude. We evaluate healthy controls and patients with depression who treated with medication and/or cognitive behavioral therapy using fMRI. Our results indicated that regional brain activities of patients with depression changed in the course of the treatment, and the changes varied among treatments.

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  • Regional cerebral blood flow in patients with pain disorder in the oral region : A SPECT study

    Grant number:18592290  2006 - 2008

    Ministry of Education, Culture, Sports, Science and Technology  Grants-in-Aid for Scientific Research(基盤研究(C))  基盤研究(C)

    Hiroyuki KARIBE, Yoshiro OKUBO, Amane TATENO, 岡田 智雄, Takashi ISHII

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    Authorship:Collaborating Investigator(s) (not designated on Grant-in-Aid)  Grant type:Competitive

    Grant amount:\4070000 ( Direct Cost: \3500000 、 Indirect Cost:\570000 )

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  • PET・SPECTを用いたうつ病の認知機能及び末梢性ベンゾジアゼピン受容体の研究

    Grant number:16790704  2004 - 2006

    文部科学省  科学研究費補助金(若手研究(B))  若手研究(B)

    舘野 周

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\2700000 ( Direct Cost: \2700000 )

    頭部MRIにて明らかな器質的病変を伴わないうつ病患者33名(認知機能障害を伴わないうつ病患者12名及び認知機能障害を伴ったうつ病患者21名)に対してハミルトンうつ病評価尺度による重症度評価及びミニメンタルステート検査による認知機能の評価を行った後、^<99m>Tc-ECDを用いたSPECT検査を実施し、統計処理ソフトを利用して健常対照群データベースを用いた比較検討を行った。認知機能を伴わないうつ病群(12名)は前部前頭葉を中心とした血流低下、うつ症状が改善した後も回復しない認知機能障害を伴ったうつ病群(14名)は後部前頭葉の血流低下、うつ症状改善により回復する認知機能障害を伴ったうつ病群(7名)は後部前頭葉・頭頂葉・後頭葉の血流低下を認めた。この結果、うつ病に伴う認知機能障害は回復するものと回復しないものとで治療開始時点で違いがあること、前頭-頭頂葉領域が、うつ病における認知機能障害の出現に関与している可能性があることを第6回国際老年精神神経薬理学会で発表した。PET検査に関しては、被検者の募集を行い5名に対して、頭部MRI、各種心理検査、[^<11>C]DAA1106を用いたPET検査を行った。うつ病患者5名と年齢を一致させた5名の健常対象群を前頭葉・側頭葉・後頭葉・小脳・前部帯状回・被殻・尾状核においてミクログリアの活性を比較検討したが、いずれの部位においても有意差を認めなかった。この結果から今回の検討ではミクログリアは反復性うつ病においては活性化していないことが明らかになった。

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  • 気分障害の病態解明、疼痛性障害の病態解明、fMRI研究、PET研究

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    Grant type:Competitive

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Teaching Experience

  • 精神医学

    Institution:日本医科大学

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