掲載種別：研究論文（学術雑誌）   出版者・発行元：Medical Association of Nippon Medical School  

DOI： 10.1272/jnms.jnms.2026_93-308

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掲載種別：研究論文（学術雑誌）   出版者・発行元：Elsevier BV  

DOI： 10.1016/j.genhosppsych.2026.04.001

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

Electroconvulsive therapy (ECT) is a very valuable treatment for mood disorders. While previous studies have examined predictors of ECT responsiveness, there is a scarcity of neuroimaging studies examining these predictors. In previous studies, it has been reported that epilepsy is significantly more common in patients with Alzheimer's disease, and it has been suggested that tau accumulation is related to the susceptibility to seizures. Positron emission tomography (PET) with florzolotau (18 F) ([18F]PM-PBB3) allows accurate quantification of tau in the brain cortex. We therefore performed tau PET with florzolotau (18 F) in 14 patients with mood disorders undergoing ECT to determine whether there is a relationship between tau accumulation and susceptibility to ECT. As a result, we found that the more tau accumulates, the more likely it is to produce effective seizures in ECT. Although our study has some limitations, it is suggested that ECT would be the first choice for treatment of depression associated with degenerative pathology such as Alzheimer's disease because tau accumulation might enhance the therapeutic efficacy of ECT.

DOI： 10.1038/s41398-026-04016-3

PubMed

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掲載種別：研究論文（学術雑誌）   出版者・発行元：Elsevier BV  

DOI： 10.1016/j.jaclp.2026.04.002

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

BACKGROUND: Suicide remains a major public health challenge across Asia, where psychiatrist shortages are severe. In Japan, psychiatric emergencies for suicide attempts frequently occur during times without psychiatrist availability. Accurate prediction of suicide itself remains difficult, therefore, the decision by psychiatrists to hospitalize suicide attempters might be a practical outcome for triage. OBJECTIVE: As a pilot study, we aimed to develop a Japanese version of the Modified SAD PERSONS Scale (MSPS-J), evaluate its reliability and validity for psychiatrists' hospitalization decisions among suicide attempters, and determine whether inclusion of an agitation item improves the performance. METHODS: This retrospective study analyzed medical records of 203 consecutive suicide attempters from 2022 to 2024. After excluding 59 cases with missing data, 144 cases were included. The primary outcome was psychiatrists' admission decisions. Receiver operating characteristic (ROC) analysis assessed predictive accuracy. Reliability was evaluated using K-fold cross-validation and bootstrapping. Sensitivity analyses using multiple imputation were performed for missing data. RESULTS: The MSPS-J achieved an AUC of 0.867 (95 % CI 0.805-0.930). At a cut-off ≥ 6, specificity was 76.3 % and sensitivity 78.7 %. Adding a one‑point agitation item raised the AUC to 0.879 and two points to 0.885. K-fold cross-validation and bootstrapping demonstrated high reproducibility. Sensitivity analysis using multiple imputation suggested robustness although selection bias of excluded cases remained. CONCLUSIONS: The MSPS-J is expected to be a practical tool to support non-specialists' decisions regarding psychiatric hospitalization in suicide attempters when psychiatrists are unavailable. MSPS-J could support suicide prevention in resource-limited clinical settings. Further study is needed.

DOI： 10.1016/j.ajp.2025.104817

PubMed

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J-GLOBAL

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