Updated on 2026/06/26

写真a

 
北川　恒実
 
Affiliation
Musashikosugi Hospital, Department of Rehabilitation, Senior Assistant Professor
Title
Senior Assistant Professor
External link

Papers

  • Dysphagia after COVID-19 Vaccination: A Report of Two Cases.

    Eiko Sunami, Yoichiro Aoyagi, Miho Ohashi, Yoko Asano, Daishi Onai, Satoshi Wakita, Yuta Kaito, Tsunemi Kitagawa, Taku Yoneyama, Satoshi Ikeda, Arito Yozu, Qing Li

    Internal medicine (Tokyo, Japan)   65 ( 12 )   1720 - 1724   2026.6

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    Various adverse reactions to COVID-19 vaccination have been reported; however, no case reports have focused on dysphagia. We herein present two cases of severe dysphagia after COVID-19 vaccination. Case 1: A 24-year-old man with Burkitt's lymphoma developed dysphagia and multiple cranial nerve palsies. Case 2: An 80-year-old man with Parkinson's disease developed aspiration pneumonia and dysphagia. Both patients underwent a detailed dysphagia evaluation and swallowing rehabilitation. According to the Vaccine Adverse Event Reporting System, dysphagia following COVID-19 vaccination is very rare. Clinicians should be aware of the appearance or worsening of dysphagia following COVID-19 vaccination.

    DOI： 10.2169/internalmedicine.5450-25

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  • Impacts of Forest Bathing (Shinrin-Yoku) in Female Participants with Depression/Depressive Tendencies. International journal

    Qing Li, Norimasa Takayama, Masao Katsumata, Hiroshi Takayama, Yukako Kimura, Shigeyoshi Kumeda, Takashi Miura, Tetsuya Ichimiya, Ruei Tan, Haruka Shimomura, Amane Tateno, Tsunemi Kitagawa, Yoichiro Aoyagi, Michiko Imai

    Diseases (Basel, Switzerland)   13 ( 4 )   2025.3

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    BACKGROUND: It has been reported that forest bathing significantly reduced negative emotions and increased the positive feelings in both healthy males and females, as well as increasing blood serotonin in healthy males, indicating the potential for a beneficial effect on depressive status. However, an improvement effect of forest bathing on participants with depression has not been reported so far. Therefore, in order to fill this gap, this study examined the effect of forest bathing on depression in female participants with depression/depressive tendencies. METHODS: Thirty-one females aged 40.1 ± 2.4 years with depression/depressive tendencies were recruited after obtaining informed consent. The study employed a randomized crossover design to compare forest bathing with city walking. They participated in day trips to a Japanese cypress forest park and to a city area of Nagano Prefecture as a control in June 2023. On both trips, they walked 2.5 km (for 90 min) in the morning and afternoon, respectively, for a total of 5.0 km per day. Blood samples were taken at 4 pm for the measurements before forest bathing on the first day and after the walking in forest and unban sites on the second and third days, at the same hospital. Concentrations of oxytocin, IGF-1, serotonin and lactic acid in blood were measured. SDS scores were calculated and the POMS test and questionnaires for subjective fatigue symptoms and sleep quality were administered before and after each trip. Temperature, humidity and illuminance were also measured in the forest and urban environments. The Nippon Medical School Central Ethics Committee approved this study. RESULTS: Forest bathing significantly decreased SDS scores compared to city walk and the baseline, and the effect lasted for one week after forest bathing. Forest bathing also significantly increased the concentrations of blood serotonin in participants who were not taking antidepressants, significantly increased the levels of oxytocin and IGF-1 in blood, significantly increased the scores for positive feelings, and reduced the scores for negative emotions compared with city walking in the POMS test. In addition, forest bathing reduced subjective fatigue symptoms and improved sleep quality. CONCLUSIONS: These findings provided scientific evidence to contribute to understanding forest bathing as a potential intervention for preventing depression, and future research on males should further explore these effects.

    DOI： 10.3390/diseases13040100

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  • Forest bathing improves inflammatory markers, SpO2, and subjective symptoms related to chronic obstructive pulmonary disease (COPD) in male subjects at risk of developing COPD. International journal

    Qing Li, Norimasa Takayama, Yukako Kimura, Hiroshi Takayama, Shigeyoshi Kumeda, Takashi Miura, Tsunemi Kitagawa, Yoichiro Aoyagi, Michiko Imai

    Journal of occupational health   67 ( 1 )   2025.1

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    BACKGROUND: Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death worldwide, responsible for 3.5 million deaths in 2021. Effective preventive measures are needed. Forest bathing has been reported to have positive effects on the immune system. In addition, the clean air, mild climate, phytoncides, high oxygen concentration, and other elements of forests are expected to have benefits for respiratory diseases such as COPD. Based on the above background, this study used a randomized crossover design to examine the improving effects of forest bathing on inflammatory markers and subjective symptoms related to COPD. METHODS: Thirty male subjects aged 63.1 ± 7.5 years were recruited after obtaining informed consent. These subjects participated in day trips to a Japanese cypress forest park and to a city area of Nagano Prefecture as a control in June 2024. Blood samples were taken in the afternoon of each day before and after the walks. Concentrations of α1-antitrypsin (α1-AT), C-reactive protein (CRP), fibrinogen, and interleukin 6 (IL-6) in blood were measured. Percutaneous oxygen saturation (SpO2), the profile of mood states (POMS), and questionnaires for subjective fatigue and respiratory symptoms and sleep quality were carried out before and after each trip. RESULTS: Forest bathing significantly decreased the concentrations of blood CRP, α1-AT, IL-6, and fibrinogen, significantly increased SpO2, reduced subjective fatigue and respiratory symptoms, improved sleep and the scores of positive feelings, and reduced the scores for negative emotions in POMS. CONCLUSIONS: Forest bathing may improve inflammatory markers, SpO2, and subjective symptoms related to COPD.

    DOI： 10.1093/joccuh/uiaf041

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  • Difficulties Nurses Report in Caring for Patients with Bone Metastases and Their Expectations after Participating in a Bone Metastasis Cancer Board: A Questionnaire Study.

    Tsunemi Kitagawa, Yasuyuki Kitagawa, Yoichiro Aoyagi, Tokifumi Majima

    Journal of Nippon Medical School = Nippon Ika Daigaku zasshi   91 ( 2 )   198 - 206   2024.5

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    BACKGROUND: Patients with bone metastases often face physical, mental, and social challenges that require multidisciplinary management. To improve treatment and practice, we conducted a questionnaire survey to assess nurses' opinions of problems related to caring for patients with bone metastases. In addition, we investigated nurses' perceptions of bone metastases after participating in a Bone Metastasis Cancer Board (BMCB). METHODS: An anonymous questionnaire survey on problems in bone metastasis treatment and the BMCB was conducted. The respondents were nurses with more than 1 year of clinical experience working in wards where patients with bone metastases were admitted. RESULTS: The number of valid responses was 224. Almost all the nurses felt anxiety about the risk of pathological fracture and paralysis while caring for patients with bone metastases. To reduce this anxiety, about 90% of the nurses supported the suggestion that "patients should be referred to an orthopedic surgeon in advance to obtain opinions on load restrictions". Nurses who had participated in the BMCB had higher expectations regarding treatment, multidisciplinary collaboration, and sharing and accumulating knowledge and experience. CONCLUSION: To improve treatment and nursing care for patients with bone metastases, it is important to make regular BMCB meetings more functional and to actively consult with specialists.

    DOI： 10.1272/jnms.JNMS.2024_91-210

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  • Rapid Recovery in a Patient with Severe COVID-19 after a Low-Load, High-Frequency Rehabilitation Program Using an Ergometer in the Supine Position.

    Akira Saito, Motomichi Masuyama, Daisuke Ishiyama, Kenta Shigeta, Tsunemi Kitagawa, Yoichiro Aoyagi

    Journal of Nippon Medical School = Nippon Ika Daigaku zasshi   90 ( 5 )   414 - 418   2023.11

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    Background Rehabilitation therapy for patients with severe coronavirus disease 2019 (COVID-19) is crucial; however, studies regarding rehabilitation strategies for intensive care unit (ICU) patients with COVID-19 are limited. We report a case of severe COVID-19 in an ICU patient whose physical function and basic movement ability rapidly improved after the initiation of active aerobic exercise in the supine position.Case A 70-year-old man with hypertension and obesity was admitted to the ICU and managed with a ventilator because of severe COVID-19. Physical therapy started on postadmission day 34. Problems encountered during physical therapy included low saturation of percutaneous oxygen (SpO2; <90%), dyspnea with a light exercise load, advancing muscle weakness, and endurance decline. The rehabilitation program included getting out of bed and resistance training of the upper and lower limbs twice daily while maintaining SpO2 at ≥90%. After ventilator weaning, we initiated aerobic training using a supine ergometer with varying load volume. On discharge from the ICU on postadmission day 45, the patient' s physical function (handgrip strength, Medical Research Council score, and Borg scale) and basic movement ability (Functional Status Score for ICU) rapidly improved.Conclusion Rehabilitation therapy involving aerobic cycling training based on a quantitative load setting may be effective in treating COVID-19.

    DOI： 10.1272/jnms.JNMS.2023_90-602

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  • Risk of Pathological Fracture and Paralysis during Rehabilitation for Patients with Bone Metastases: A Questionnaire-Based Study.

    Tsunemi Kitagawa, Yasuyuki Kitagawa, Yoichiro Aoyagi, Tokifumi Majima

    Journal of Nippon Medical School = Nippon Ika Daigaku zasshi   90 ( 4 )   326 - 332   2023.9

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    BACKGROUND: Bone metastases can cause severe pain, pathological fractures, and spinal cord paralysis, which interrupt treatment for tumors and cause patients to be bedridden. In this study, we aimed to clarify therapists' problems in the rehabilitation of patients with bone metastases and their countermeasures using the results of questionnaires to therapists and recommend safer and more rational rehabilitation. METHODS: Questionnaire forms were sent to 21 therapists in our department. The questionnaire was conducted anonymously about problems during the rehabilitation procedure such as the risk of pathological fractures and paralysis. RESULTS: All of the therapists had strong anxiety (43%) or some anxiety (57%) about the risk of pathological fractures or paralysis during a procedure. However, no therapist responded that this had ever occurred. Many of the respondents had changed a procedure to a milder one (81%) or interrupted a procedure (48%) due to the patient's condition on the day. Therapists chose many options to reduce the risk of pathological fractures and paralysis during the procedure. Among them, "pre-rehabilitation referral to orthopedic surgeon" (86%), "consultation with a doctor about changes in patient's symptoms and findings" (86%), and "regular cooperation between multiple occupations" (67%) were frequently selected. CONCLUSION: Our questionnaire survey of therapists regarding the treatment of patients with bone metastases found that there was considerable anxiety about the risk of pathological fractures and paralysis during treatment. Our findings suggest that it is necessary to strengthen cooperation with multiple occupations, especially those in the orthopedic field.

    DOI： 10.1272/jnms.JNMS.2023_90-304

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  • 重度熱傷を受傷した高齢男性患者の運動耐容能改善が得られた1症例

    矢部 健汰, 齊藤 彬, 増山 素道, 北川 恒美, 青柳 陽一郎

    The Japanese Journal of Rehabilitation Medicine   ( 特別号 )   S189 - S189   2022.5

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    Language：Japanese   Publisher：(公社)日本リハビリテーション医学会  

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  • 好酸球増多症に嚥下障害を伴った一例

    角南 英子, 北川 恒実, 李 卿, 四津 有人, 青柳 陽一郎

    The Japanese Journal of Rehabilitation Medicine   ( 特別号 )   S136 - S136   2022.5

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  • 好酸球増多症に嚥下障害を伴った一例

    角南 英子, 北川 恒実, 李 卿, 四津 有人, 青柳 陽一郎

    The Japanese Journal of Rehabilitation Medicine   ( 特別号 )   S136 - S136   2022.5

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  • 低負荷・高頻度のリハビリテーションプログラムにて、身体機能と基本動作能力が改善した重症COVID-19症例

    齊藤 彬, 増山 素道, 石山 大介, 重田 健太, 北川 恒実, 青柳 陽一郎

    The Japanese Journal of Rehabilitation Medicine   58 ( 秋季特別号 )   S478 - S478   2021.10

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  • 骨転移患者リハビリテーション診療実施における病的骨折及び麻痺のリスクについて アンケート調査(第二報)

    北川 恒実, 北川 泰之, 青柳 陽一郎

    The Japanese Journal of Rehabilitation Medicine   58 ( 秋季特別号 )   S432 - S432   2021.10

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  • [The effects of a respiratory education class on psychological status for patients with chronic respiratory disease].

    Eiichi Sudo, Hiroaki Kitade, Tsunemi Kitagawa, Minoru Kawaguchi

    Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics   43 ( 5 )   630 - 4   2006.9

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    AIM: To educate patients with chronic respiratory disease about respiratory diseases and pulmonary rehabilitation, a respiratory education class was held for patients with chronic respiratory diseases and their families. In this study, we evaluated the psychological effects of the class. METHODS: The respiratory education class was held twice during the 2-year period (2002-2004) while the physician specializing in geriatric and respiratory diseases worked at the hospital. Before, during, and one year after the class, we investigated the mental and physical condition in 24 chronic respiratory patients (aged 72.7 +/- 1.3 years) using the State-Trait Anxiety Inventory (STAI) to measure anxiety, the Self-Rating Depression Scale (SDS) to evaluate depressive state, and the General Self-Efficacy Scale (GSES) to evaluate self-efficacy. RESULTS: Before, during, and one year after the class, the mean STAI scores were 39.2 +/- 2.5, 40.0 +/- 2.5, and 39.4 +/- 2.7, the mean SDS scores were 37.6 +/- 22, 37.0 +/- 2.0, and 38.0 +/- 2.0, and the mean GSES scores were 7.4 +/- 0.7, 8.0 +/- 0.8, and 8.6 +/- 0.8, respectively. No statistically significant difference was observed for scores on the STAI, SDS between the time points. The score during the class significantly (p < 0.05) increased compared to the score before the class, and remained significantly increased one year after the class on the GSES. CONCLUSION: These results suggest that conducting a respiratory education class might be beneficial for patients with chronic respiratory disease.

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  • [The influence of complications on rehabilitation of spinal cord injuries: economical minus effects and physical disadvantages caused by urinary tract infection and decubitus ulcer].

    Tsunemi Kitagawa, Tetsuhiko Kimura

    Journal of Nippon Medical School = Nippon Ika Daigaku zasshi   69 ( 3 )   268 - 77   2002.6

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

    There are few studies on the many complications that disrupt the rehabilitation of patients with cervical cord injuries and their subsequent health-economic benefits. I particularly focused on the treatment of urinary tract infection and decubitus ulcers because these are very frequently encountered complications in a clinical setting. I examined how these complications affect the progress of rehabilitation and facilitate a patient's return to society. The subjects included ninety-eight cervical cord injury patients with tetraplegia who were discharged from the Rehabilitation Center for Severely Disabled Persons from 1995 to 2000. I retrospectively investigated these ninety-eight subjects regarding ninety-six items from clinical records, among which twenty items were selected because they are considered to be closely associated with outcome, such as age, sex, length of stay, medical expense, urinary tract infection, and decubitus ulcer. Moreover, I examined the influence that urinary tract infection and decubitus ulcer had on other items. The average length of stay and total medical expenses per patient were 1,174.4 +/- 559.9 days and 13,563,128.4 +/- 6,351,078.1 yen, respectively. Urinary tract infection and decubitus ulcer occurred at a rate of 97% in patients with cervical cord injury undergoing chronic stage rehabilitation, and these complications caused a two-fold prolongation of the length of stay and a three-fold increase in medical expenses compared with patients without complications. It is important to fully recognize that these complications produce many expenses as well as those for the medical treatment of cervical cord injury.

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  • 小柴胡湯によるC型慢性肝炎から肝硬変への進展抑制効果

    中島 修, 曽根 美好, 大西 英胤, 井上 恒美, 杉本 健, 荻野 宏, 諸星 政治, 佐久間 徹, 黒川 香, 小林 潔正, 西野 義隆, 新浪 千加子, 麻生 智子, 野口 三四朗, 畔田 浩一, 長谷川 慶華

    臨牀と研究   76 ( 5 )   1008 - 1016   1999.5

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    INF療法を終了したC型慢性活動性肝炎100例のうち陰虚証の1例を除外した99を2群に分け,カネボウ小柴胡湯1日6gを食前分三に服用(A群)し,B群には一般の肝庇護薬を与え,更にINF未治療の同肝炎患者13例に肝庇護薬を与え,対照として比較した.その結果ALT値でA群に有意の改善を示した.またHCV-RNAは有意にA群で50ヵ月で低値(p<0.05)を示した

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  • 抗α型インターフェロン抗体陽性のC型慢性活動性肝炎症例にβ型インターフェロンを投与し奏効した2例

    小林 潔正, 西野 隆義, 井上 恒美

    医学と薬学   37 ( 3 )   737 - 740   1997.3

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    Language：Japanese   Publisher：(株)自然科学社  

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