記述言語：日本語   出版者・発行元：(公社)日本臨床細胞学会  

背景:肺粘表皮癌はまれな腫瘍であり、粘膜下腫瘍様の形態をとることから気管支擦過細胞診での組織型推定がしばしば困難となる。気管支擦過および洗浄検体にて術前細胞診断に苦慮した肺低悪性度粘表皮癌の1例を経験したので報告する。症例:40歳代、女性。検診にて胸部異常陰影を指摘され当院を受診し、胸部CTにて左下葉気管支内に境界明瞭な結節を認めた。気管支擦過・洗浄細胞診では、核がほぼ中心性で異型の弱い多陵形細胞と、ごくわずかではあるが核偏在性で細胞質に多量の粘液を含んだ泡沫状の細胞を認めた。しかしいずれも異型に乏しく、細胞量も少なかったため、組織型推定は困難であった。最終的に生検および手術検体で肺低悪性度粘表皮癌と診断された。結論:下気道発生の粘表皮癌の細胞診断においては気管支擦過細胞診に比べ、穿刺吸引細胞診での検体採取が有用とされているが、異型の弱さや採取されてきた細胞の各成分の割合、細胞量によっては診断が困難となることがある。細胞の採取方法にとらわれず、特徴的な細胞像を理解し、臨床像、画像所見や腫瘍の発生部位から粘表皮癌の可能性を念頭に置くことが肝要である。(著者抄録)

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記述言語：日本語   出版者・発行元：(NPO)日本呼吸器内視鏡学会  

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記述言語：日本語   出版者・発行元：(NPO)日本呼吸器内視鏡学会  

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記述言語：日本語   出版者・発行元：(NPO)日本肺癌学会  

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記述言語：日本語   出版者・発行元：(一社)日本内分泌学会  

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記述言語：日本語   出版者・発行元：(NPO)日本呼吸器内視鏡学会  

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.5761/atcs.nm.18-00066

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記述言語：日本語   出版者・発行元：(NPO)日本呼吸器外科学会  

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記述言語：日本語   出版者・発行元：(NPO)日本呼吸器外科学会  

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記述言語：日本語   出版者・発行元：(NPO)日本呼吸器外科学会  

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Oxford University Press  

OBJECTIVES: Division of incompletely lobulated fissures is often performed during surgical resection of non-small-cell lung cancer (NSCLC)
however, the effect of lobulation on tumour recurrence is unclear. This study aimed to assess the prognostic effect of lobulation in patients with NSCLC according to their preoperative and operative findings. METHODS: A retrospective study of patients with p-stage I NSCLC who underwent lobectomy was conducted between April 2008 and April 2016. A receiver operating characteristic curve of the number of stapling cartridges was constructed to determine the optimal cut-off value. Patients who underwent division of the interlobar fissure using 2 or more stapling cartridges (H group) were compared with those who did not undergo division of the interlobar fissure or who underwent division of the interlobar fissure using only 1 cartridge (L group). RESULTS: The study included 85 patients, and of these patients, 46 were included in the L group and 39 in the H group. Survival analysis showed better disease-specific survival (P = 0.0135) and disease-free survival (P = 0.0412) in the L group. Cox regression analysis showed better disease-specific survival in patients who underwent division of the interlobar fissure with few stapler cartridges than in those who underwent division with more stapler cartridges (P = 0.021). CONCLUSIONS: The extent and status of incompletely lobulated fissures are significant risk factors for disease-specific survival in patients with resected p-stage I NSCLC.

DOI： 10.1093/icvts/ivx305

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：MEDICAL TRIBUNE INC  

Background: In the elderly patients, optimal surgical treatment can be difficult to achieve, because of comorbidity. Therefore, we aimed to clarify the preferred surgical management in this patient group.
Methods: A retrospective study was conducted between April 2008 and March 2015 that included patients with non-small cell lung cancer (NSCLC) aged >= 75 years.
Results: We included 44 patients who underwent partial resection (n = 20) or lobectomy (n = 24). There were no significant differences between the two groups on most variables, except for some character. Survival analysis revealed a significant difference in overall survival (OS) between the two groups; however, no significant differences existed in the disease-free survival or in the OS for stage I disease. Postoperative complications led to poor prognoses. Cox regression analysis revealed statistical significance for the Brinkman Index, the ratio of the pulmonary artery diameter to the ascending aorta diameter (PA:A), and the alveolar-arterial oxygen gradient. Only the PA:A ratio remained significant after multivariate analysis, with a higher ratio associated with better survival.
Conclusion: In elderly patients with NSCLC, surgical resection should not be denied because of age alone. However, partial resection should be favored to lobectomy when possible.

DOI： 10.5761/atcs.oa.15-00365

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：BIOMED CENTRAL LTD  

Background: Video-assisted thoracoscopic surgery (VATS) lobectomy is increasingly used for pulmonary sequestration; however, there are few descriptions of safe handling of the aberrant artery. Here we clarify the safe handling of an aberrant artery using a clinical review and an experimental model.
Methods: We retrospectively reviewed the records of patients who underwent lobectomy for pulmonary sequestration with aberrant arteries at the Nippon Medical School between January 2008 and December 2010. This was supplemented by an experimental pressure test using vessels obtained from pigs.
Results: We identified four patients with aberrant arteries that were successfully occluded via either stapling. In the experimental model, we divided pig vessels into small-diameter (S) and large-diameter (L) groups. The 1.0-mm-high staples were stronger in the S group than in the L group (p = 0.028). In the L group, the 2.0-mm-high staples were stronger than the 1.0-mm staples (p = 0.015). Leakage from the staple line was associated with a poorer B-shape of inserted staples.
Conclusions: The techniques described in this report are useful in successful minimally invasive transection of an aberrant artery (other than very thin vessels) when resecting a pulmonary sequestration by stapler only. A detailed investigation should be performed to determine the most appropriate stapler or cartridge.

DOI： 10.1186/s12893-015-0009-1

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記述言語：日本語   出版者・発行元：特定非営利活動法人 日本呼吸器外科学会  

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記述言語：日本語   出版者・発行元：日本医科大学医学会  

Background: Spontaneous pneumothorax is a relatively rare complication of lung cancer. Herein, we report two cases of lung cancer <i>in situ</i> with spontaneous pneumothorax as the initial symptom. Cases: Case 1: A 63-year-old male presented to our outpatient clinic with chest discomfort. He had a collapsed lung, and we inserted a chest drainage tube through the thoracic cavity to re-expand the lung. Computed tomography of the chest showed a large emphysematous bulla at the lung apex. Video-assisted thoracoscopic surgery was used to resect the bulla, and the final pathological diagnosis was an emphysematous bulla with adenocarcinoma <i>in situ</i>. Case 2: A 45-year-old man presented to our outpatient clinic with pain in the left chest and dyspnea. To treat an almost completely collapsed lung, we inserted a chest drainage tube into the thoracic cavity. Air leakage continued for a few days, so we resected the bulla. The final pathological diagnosis was an emphysematous bulla with a squamous cell carcinoma <i>in situ</i>. Conclusion: It is important to consider the possibility of lung cancer in patients with pneumothorax and emphysematous changes, especially in middle-aged or elderly patients.

DOI： 10.1272/manms.11.161

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：MEDICAL ASSOC NIPPON MEDICAL SCH  

The form and timing of the local recurrence of lung cancer can be unpredictable and unexpected. Pseudomesotheliomatous adenocarcinoma is a rare tumor that mimics malignant pleural mesothelioma both clinically and pathologically. Distinguishing pseudomesotheliomatous adenocarcinoma from malignant pleural mesothelioma on the basis of clinical findings can be difficult; therefore, a biopsy is usually required for diagnosis. Here we report on a 73-year-old Japanese man who presented with extensive dissemination along the pleural surfaces and clinical findings similar to those of pseudomesotheliomatous lung cancer 10 years after undergoing left upper lobectomy for lung adenocarcinoma. This report provides information that will help physicians establish an accurate diagnosis in similar cases.

DOI： 10.1272/jnms.81.173

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記述言語：日本語   出版者・発行元：特定非営利活動法人 日本呼吸器外科学会  

肺アスペルギローマでは拡張した空洞と胸腔が交通する場合があり，菌球除去のみを行った際には有瘻性膿胸を予防する手技が必要である．今回，空洞切開菌球除去を行った後に瘻孔となった気管支周囲の巾着縫合と，肺縫縮による臓側胸膜ラッピングで2層の閉鎖を行った結果，合併症無く終了しえた．1年経過後も，再発を来していない．この経験から，本術式は有効なものと考えられた．

DOI： 10.2995/jacsurg.28.707

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1055/s-0033-1348477

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記述言語：日本語   出版者・発行元：日本医科大学医学会  

We report the case of a 16-year-old boy who developed chylothorax after the chest tube insertion for spontaneous pneumothorax. The patient was admitted to our hospital for right spontaneous pneumothorax that required thoracic drainage. After chest tube insertion, we noticed chylous effusion discharging from the tube. Although this discharge of chylous effusion gradually decreased after the patient was put on a fat-restricted diet, we performed video-assisted thoracic surgery (VATS) for continuous air leakage 9 days after admission. The patient's postoperative course was excellent. The chest tube was removed 5 days after surgery (POD5), and the patient was discharged the following day (POD6).<br> Chest tube insertion was usually a blind procedure; therefore, the location of the chest tube should receive special attention in order to prevent any unexpected thoracic injury.<br>

DOI： 10.1272/manms.9.156

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：MEDICAL ASSOC NIPPON MEDICAL SCH  

A 58-year-old man was admitted to our hospital because of dyspnea, dysphagia, and back pain. A chest roentgenogram showed bilateral pleural effusion. Bloody fluid was aspirated via thoracocentesis, but no malignancy was detected on cytological examination. Computed tomography revealed a hypodense circular mass approximately 8 cm in diameter with well-defined margins in the posterior mediastinum. Furthermore, T2-weighted magnetic resonance imaging showed the lesion to be a hyperintense mass. Video-assisted thoracoscopic surgery was performed, and the tumor was diagnosed as a mediastinal cystic hemangioma. The bilateral bloody pleural effusion was attributed to the cystic tumor. (J Nippon Med Sch 2012: 79: 381-384)

DOI： 10.1272/jnms.79.381

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：ELSEVIER SCIENCE INC  

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：MEDICAL TRIBUNE INC  

Purpose: We report our experience with completion pneumonectomy (CP).
Methods: We report on operative procedure and morbidity, mortality, and survival rates.
Results: CP was performed for malignancy in 12 patients and postoperative complications after the first operation in 4 patients. Intrapericardial dissection of vessels was performed in 14 patients (87.5%). Partial vertebrectomy from the second to the fifth vertebrae was performed in 1 patient. Carinal resection was performed in 2 patients. Morbidity including bronchopleural fistula, pulmonary insufficiency, pyothorax, and pulmonary infarction developed in 6 of the 16 patients (37.5%). Mortality rate was 18.8%. The actuarial 1-, 3-, and 5-year overall survival after CP for all malignancy was 80.8%, 49.0%, and 49.0% respectively.
Conclusions: The morbidity and mortality rates are high in CP. Combined resection, especially carinal resection, appears to be contraindicated in CP. CP is one of the treatments of choice, even for malignancy, if complete resection is possible because of the good long-term survival.

DOI： 10.5761/atcs.oa.09.01502

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：MEDICAL TRIBUNE INC  

Purpose: We report surgical results of metachronous nonsmall cell lung cancer (NSCLC).
Methods: We report mortality and analyze prognostic factors for overall survival in patients with metachronous NSCLC at Nippon Medical School from July 1982 to July 2008.
Results: Thirty-three out of 1726 patients (1.9%) who underwent lung resection had metachronous NSCLC. Mortality rate was 10%. On univariate analyses, the different histologies at the first and second operations were the only significant poor prognostic factor. Twenty-two patients (73%) had the same histology at the first and second operations: adenocarcinoma in 18 (60%) and squamous cell carcinoma in 4 (13%). Their actuarial 5- and 10-year overall survivals were both 71%, compared to 47% and 16% for patients with different histology (p = 0.0174). Sex (p = 0.1742), locations of the first and second cancers (p = 0.3957), operative procedures in patients with p-stage I at the second operation (p = 0.2782), pathological stage at the first operation (p = 0.5958), and pathological stage at the second operation (p = 0.0609) were not prognostic factors. Different histology at the first and second operations was significant based on a multivariate analysis (Hazard ratio: 3.918; p value: 0.0269; 95% confidence interval: 1.169-13.131). The actuarial 5- and 10-year overall survivals for the first cancer was 86% and 64%, compared to 65% and 45% for the second (p = 0.0609).
Conclusions: Our study shows that a surgical approach is beneficial for patients with metachronous NSCLC. Good prognosis in patients with the same histology may support the current criteria of metachronous NSCLC mainly based on the histology. (Ann Thorac Cardiovasc Surg 2010; 16: 319-325)

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：MEDICAL TRIBUNE INC  

We report a glomus tumor of the bronchus that showed invasion of the neural area and extrabronchial extension without significant histological malignancy. The patient was a male in his late 30s with the chief complaint being hemosputum. CT revealed a nodal shadow 15 mm in diameter in the right bronchus intermedius. An irregularly protruding lesion on the tumor surface was observed by bronchoscopy immediately under the second carina in the right truncus intermedius, but could not be diagnosed because of bleeding. Sleeve lobectomy of the right upper lobe was performed, since carcinoid tumor was suspected in open chest biopsy and intraoperative frozen section diagnosis. A solid growth of spherical and cubic uniform cells with a clear eosinophilic cytoplasm and spherical nuclei was observed. Immunohistochemistry was positive for alpha-smooth muscle actin and type IV collagen, weakly positive for synaptophysin, and negative for keratin, neural cell adhesion molecule, chromogranin A, desmin, CD34, and S100, leading to a diagnosis of glomus tumor. Neuroinvasion and extrabronchial tumor extension were observed, but an atypical cytology, bleeding, or necrosis was found histologically. This is the first description of infiltrative glomus tumor of the bronchus. (Ann Thorac Cardiovasc Surg 2010; 16: 113-117)

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：MEDICAL TRIBUNE INC  

We herein describe a patient we encountered in whom mediastinal lymph node metastasis of lung cancer with an unknown primary lesion was complicated by both an endocrine abnormality and acanthosis nigricans. A 66-year-old male visited a local hospital and was diagnosed as having acanthosis nigricans. The patient was referred to our hospital for further examination. Computed tomography scans of the chest and the abdomen showed no adverse findings except for an enlargement of the mediastinal lymph node. No malignant lesions were detected in examinations of the upper gastrointestinal tract. Based on the above findings, the lesion was thus considered to possibly be mediastinal lymph node metastasis of an unknown primary tumor or malignant lymphoma. A thoracoscopic biopsy of the mediastinal lymph node was performed. The patient was diagnosed to have mediastinal lymph node metastasis of lung cancer with an unknown primary lesion and endocrine abnormality resulting from paraneoplastic syndrome. Palliative radiation therapy was initiated to prevent superior vena cava syndrome and esophageal passage failure or dysphagia. The cutaneous lesions markedly improved thereafter. The serum levels of adrenocorticotropic hormone decreased. (Ann Thorac Cardiovasc Surg 2009; 15: 397-400)

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：MEDICAL TRIBUNE INC  

Purpose: We report surgical results of lung cancer associated with postobstructive pneumonia.
Materials and Methods: We report on morbidity and mortality, and we analyze the risk factors for them and the prognostic factors for overall survival of patients without mortality.
Results: Morbidity developed in 13 of the 38 patients (34.2%). Mortality rate was 10.5%. Hemoglobin concentration before surgery and predicted postoperative forced expiratory volume in one second were significantly low in patients with morbidity and mortality based on the univariate analyses. Predicted postoperative forced expiratory volume in one second was a significant risk factor for morbidity based on a multivariate analysis. Poor prognostic factors for overall survival were serum albumin concentration, hemoglobin concentration, and performance status before surgery, combined resection, and pathological stage. Serum albumin concentration was significant based on a multivariate analysis.
Conclusions: Morbidity and mortality are high in patients with lung cancer associated with postobstructive pneumonia. Morbidity demonstrates significant association with low predicted postoperative forced expiratory volume in one second and hemoglobin concentration, indicating the need for preoperative transfusion in severe anemia or bronchoplasty if possible. Poor nutritional state before surgery possibly derived from cachexia may influence not only morbidity and mortality, but also prognosis. (Ann Thorac Cardiovasc Surg 2009; 15: 297-303)

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：MEDICAL TRIBUNE INC  

A 16-year-old male patient was admitted to the hospital for a medical workup to examine an anterior mediastinal tumor in April 2000. A tumor excision and a right lower lung lobe nodule resection were performed in June 2000. The tumor tissue showed a cobblestone-like proliferation of atypical cells containing a discrete nucleolus that were aligned in an epithelial fashion against mainly lymphocytic inflammatory cells in the background; also shown were undifferentiated tumor cells with epithelioid characteristics. Immunohistochemical staining for CD5, CD99, and KIT (CD117) revealed that the tumor cells were CD5-negative and that some of the lymphocytes infiltrating the tumor tissue stained positive for CD99 and negative for KIT. The lesion was therefore diagnosed to be a type B3 thymic epithelial tumor. (Ann Thorac Cardiovasc Surg 2009; 15: 324-327)

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記述言語：日本語   出版者・発行元：日本サイトメトリー学会  

<p>CD40 is a member of the tumor necrosis factor (TNF) receptor superfamily of molecules and is known to play an important role in normal dendritic cell and B-cell maturation. However, the function of CD40 in malignant neoplasms, especially solid tumors, remains largely unknown. We previously reported CD40-CD40L stimulation had the anti-tumor effect in non-small cell lung cancer cell lines which expressed CD40 on their surface in vitro study. Detection of CD40 expression of the tumor cell is usually examined by FACS, not by immunohistochemical staining (IHC). As far as we know, IHC of CD40 has not been reported yet. Therefore, if IHC of CD40 could be examined from paraffin embedded specimens, the role of CD40 in malignant tumors might become clear from the clinicopathological findings. CD40 expression could be detected by IHC from the paraffin embedded specimens of lung adenocarcinomas. We observed enhanced IHC of CD40 in all specimens of N2 cases, in contrast none of N0 cases was expressed. CD40 expression rate was much higher in N2 cases than N0 cases from our experiment. Thus, CD40 may play an important role in lymph node metastasis in lung cancer. Further investigations are required to clarify the mechanism of CD40 on lung cancer.</p>

DOI： 10.18947/cytometryresearch.19.1_41

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：MEDICAL TRIBUNE INC  

Pulmonary carcinosarcoma is a rarely encountered tumor. We treated a patient who had an intrabronchial polypoid lesion that required a diagnostic differentiation from epithelial-mesenchymal mixed neoplasms inclusive of pleomorphic adenoma, and that was diagnosed by immunohistochemical staining to be a true carcinosarcoma. A 69-year-old man underwent left pneumonectomy in November 2000 with a diagnosis of atelectasis resulting from a tumor obstructing the left lower lobar bronchus, and also a lung abscess. The tumor was initially diagnosed as pleomorphic adenoma, since it contained both benign-looking epithelial and mesenchymal elements, but immunohistochemical staining demonstrated myoglobin-positive rhabdomyosarcomatous elements along with cytokeratin-positive squamous cell carcinoma elements. A definite diagnosis of pulmonary carcinosarcoma was confirmed. (Ann Thorac Cardiovasc Surg 2009; 15: 42-45)

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：MEDICAL TRIBUNE INC  

Extramedullary hematopoiesis (EMH) is a rare disease associated with hematologic disorders. This report describes a case of posterior mediastinal mass found by occurring spontaneous pneumothorax in a 48-year-old male. The intrathoracic mass resected using video-assisted thoracic surgery (VATS) was diagnosed thoracic EMH (TEMH). No disorders were found by hematologic exams before or after surgery. This report suggests that such lesions must therefore be considered in the differential diagnosis of posterior mediastinal tumors presenting with no hematologic disorders. (Ann Thorac Cardiovasc Surg 2008; 14: 382-385)

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記述言語：日本語   出版者・発行元：日本医科大学医学会  

Anomalous systemic arterial supply to the basal segment of the left lung (ABLL) is a rare congenital disorder in which an aberrant artery arising from the descending thoracic aorta supplies the basal segment of the left lower lobe, which is then drained through the normal pulmonary vein. We report two cases of ABLL treated at Nippon Medical School Chiba Hokusoh Hospital. The first patient was a 56-year-old woman who was admitted to our hospital because of hemoptysis. ABLL was suspected on the basis of computed tomography of the chest. The second patient was a 22-year-old man who was admitted to the emergency room of another hospital presenting with severe hemoptysis due to a contusion of the back, and was then transferred to our hospital after the symptoms improved. ABLL was diagnosed in both patients by means of bronchoscopy and angiography (aortography and pulmonary arteriography). Left lower lobectomy and ligation of aberrant artery were successfully performed.<br>

DOI： 10.1272/manms.4.118

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記述言語：日本語   出版者・発行元：日本医科大学医学会  

Thymic hyperplasia commonly presents in association with Grave's disease. We report on a patient in whom Grave's disease was diagnosed after thymectomy. The patient, a 53-year-old man, was initially suspected to have thymoma, thymectomy was performed. Tachycardia and a high-grade fever developed immediately after surgery, suggesting thyroid crisis. The patient was treated with antithyroid drugs and beta blockers. The patient's condition improved thereafter, and the patient was discharged on the 18th hospital day. Histopathological examination of the resected thymic tissue revealed thymic hyperplasia. To our knowledge, there have been no reported cases of Grave's disease which had not been detected until the development of postoperative thyroid crisis, as in our patient. Therefore, we report this case with discuss the treatment performed.<br>

DOI： 10.1272/manms.4.115

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記述言語：日本語   出版者・発行元：日本サイトメトリー学会  

<p>Cortactin（EMS-1）とは，細胞骨格，細胞分化，及び細胞接着に対して重要な役割を果たしている遺伝子であり，F-actinや微小管などの因子との因果関係についても報告がある。現在までに多数の癌でのover-expressionが報告されているが，詳しい作用機序などは未だ不明である。肺癌でも好発現の傾向が見られていることから今回，si-RNAを用いてCortactinのノックダウン細胞を作成し，実験を行ったところ，F-actinの減少による運動能の低下がみられた。そして，Microtubeの局在変化が顕著に見られた。 次に，そのfibronectinをCortactinのノックダウン細胞に添加したところ，apoptosisを示唆する核異型細胞が多数見られた。 以上より，癌においてCortactinがF-actinのbinding factorとしてだけではなく，Microtubeの関連遺伝子としても働いていることが示唆された。 そして，cortactin，fibronectinの相互作用が癌細胞のapoptosisに影響を与えている事がかさねて示唆された。</p>

DOI： 10.18947/cytometryresearch.18.1_19

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記述言語：日本語   出版者・発行元：日本医科大学医学会  

We treated 40 consecutive cases of spontaneous pneumothorax (SP) with video-assisted thoracic surgery (VATS) in 2004. To develop and introduce a clinical pathway (CP) of VATS for patients with SP, we reviewed the 40 cases in this study. All patients were managed before and after surgery according to the newly established program through manuals and an ordering system (including intravenous infusion, radiography, laboratory tests, and prescriptions). The 40 patients were 35 men (87.5%) and 5 women, with an average age of 30.5 years. In addition, 27 patients (67.5%) were younger than 30 years. The operation sites were right, 18 cases; left, 20 cases; and bilateral, 2 cases. The average surgical duration was 65.6 minutes (excluding 2 bilateral cases). The postoperative duration of thoracic drainage was 1.7 days, and the drain was removed the day after surgery in 35 of 38 patients (excluding the bilateral cases). Only 2 patients (5%) required drainage for more than 1 week. The postoperative stay was 3.2 days; 21 patients (52.5%) were discharged on the second day after surgery, and 8 patients (20%) were discharged on the third day. In addition, 2 patients required hospitalization for more than 1 week. These results show that our programmed management system using VATS for patients with SP is effective and appropriate as a clinical pathway.<br>

DOI： 10.1272/manms.3.11

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：KARGER  

Background: There are gender differences in multiple primary malignancies associated with lung cancer ( MPMLC) in terms of clinical characteristics. However, the importance of these differences in the management of patients has not been clarified. Objective: Differences in characteristics affected by gender were investigated in MPMLC to identify factors important for the proper management of the patients. Methods: Univariate and multivariate analyses were performed between 82 male and 34 female patients with MPMLC treated from August 1982 to March 2002. Results: In univariate analysis, the numbers of smokers or ex-smokers, smoking-related cancer and synchronous multiple primary malignancies were signicantly increased in males with MPMLC ( p < 0.0001, p < 0.05 and p < 0.05, respectively). In multivariate analysis, synchronous multiple primary malignancies and the number of smokers or ex-smokers were signicantly different between male and female MPMLC. Gastric, lung and colon cancers were major constituents in male MPMLC, and 40.2% of all malignancies were smoking-related cancers. On the other hand, breast and uterine cancers were major constituents in female MPMLC, and only 20.6% of all MPMLC were smoking-related cancers. Conclusions: Male patients with MPMLC demonstrated signicant smoking history and synchronous multiple primary malignancies, indicating the need for different approaches to properly manage and follow up male versus female MPMLC patients. Copyright (C) 2006 S. Karger AG, Basel.

DOI： 10.1159/000093324

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

Background: Bronchopleural fistula is a poentioally fatal complication of pulmonary resections, especially pneumonectomy. Methods: Univariate and multivariate analyses of the development of bronchopleural fistula were performed in 12 patients with bronchopleural fistula and 102 patients without bronchopleural fistula who had undergone pneumonectomy from January 1983 through December 2005. Results: Bronchopleural fistula developed after pneumonecotomy in 12 patients (8.5%). Seven (58.7%) of the 12 patients died of bronchopleural fistula. Univariate analysis showed that preoperative infection, right pneumonectomy, and pathological N2, 3 disease significantly contributed to the development of postpneumonectomy bronchopleural fistula (p=0.0002, p= 0.0043, and p=0.0387, respectively). Multivariate analysis also showed that preoperative infection, right pneumonectomy, and pathological N2, 3 disease were significant risk factors for postpneumonectomy bronchopleural fistula. Conclusions: Bronchopleural fistula is strongly associated with preoperative infection, right pneumonectomy, and pathological N2, 3 disease. Bronchial stump coverage with pedicled tissue flaps and preservation of the bronchial arteries during mediastinal lymphnode dissection are recommended to maintain the blood supply to the bronchial stump in patients at risk.

DOI： 10.1272/jnms.73.314

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

We encountered a male patient aged 64 with pulmonary mucinous carcinoma in whom a diagnosis of pulmonary metastasis from early rectal cancer with submucosal invasion was made based on an immunohistochemical examination. A rectal cancer was detected together with a mass in the lung. The mass in the lung was consistent with mucinous adenocarcinoma, whereas the invasion of rectal cancer was confined to the submucosa
thus, distant metastases appeared unlikely. These lesions were assessed using immunohistochemical staining for cytokeratin and thyroid transcription factor-1, which failed to make a definite diagnosis. A further assessment was made by staining for villin. Both neoplasms were positive for this protein, demonstrating a common brush-border pattern. A lung metastasis from rectal cancer with submucosal invasion was diagnosed. Villin is considered useful for detecting primary neoplastic lesions based not only on its specificity but also on its staining pattern, which is different from that of other proteins. © The Japanese Association for Thoracic Surgery 2006.

DOI： 10.1007/s11748-006-0006-5

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：The Medical Association of Nippon Medical School  

添付ファイル： 073010042.pdf

DOI： 10.1272/jnms.73.42

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記述言語：日本語   出版者・発行元：特定非営利活動法人 日本呼吸器外科学会  

DOI： 10.2995/jacsurg.20.884_3

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

Primary lymphoepithelioma-like carcinoma (LELC) of the lung is a very rare disease. There is very little long term follow-up data about this disease. A 60-year-old woman was found to have abnormalities according to a routine chest X-ray examination. She was admitted to our hospital in March 1998. Since a malignant tumor of the right lung was suspected, surgical resection was performed in April of the same year. Pathological diagnosis was LELC of the lung. Its pathological stage was T1N0M0 stage IA. It has been reported that this carcinoma is associated with Epstein-Barr virus (EBV) infection. However, the patient's tumor cells were negative for EBV as examined with RNA in situ hybridization technique. She is alive and has been free from recurrence of the disease over 7 years postoperatively.

DOI： 10.1007/BF02665079

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記述言語：英語  

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DOI： 10.1272/jnms.72.34

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

Purpose: We analyzed the risk factors predisposing patients to develop postoperative respiratory complications (PRCs) in VATS lobectomy and segmentectomy for lung cancer, retrospectively. Methods: Both univariate and multivariate analyses of PRCs were performed in seventy-five patients who had undergone VATS lobectomy and segmentectomy for lung cancer from November 1994 to December 2000. Results: Univariate analysis of the development of PRCs revealed that the significant risk factors were age, ppo%VC, ppo%FEV, ppoFEV, poor pulmonary function, and duration of surgery. Multivariate logistic regression test in regard to the development of PRCs revealed that duration of surgery was the most significant risk factor. On the basis of the receiver operator characteristic analysis, duration of surgery more than 297 min had a sensitivity of 70% and a specificity of 66% for the development of PRCs. Conclusions: The duration of surgery should be less than five hours not to lose advantages of VATS lobectomy and segmentectomy. Therefore, if the duration of surgery is more than five hours for any reasons, conversion to limited thoracotomy or muscle-sparing methods is recommended.

DOI： 10.1272/jnms.71.30

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：MOSBY, INC  

Introduction: Esophageal cancer remains a highly lethal malignancy, with therapeutic options of limited efficacy in the majority of patients. Understanding the molecular events involved in the pathogenesis of esophageal cancer offers insight into potential targets for treatment. Beta catenin and Writ signaling abnormalities are involved in the development of both adenocarcinoma and squamous carcinoma of the esophagus. We hypothesized that down-regulation of beta catenin would inhibit the growth of human esophageal cancer.
Methods: A human esophageal squamous cell carcinoma cell line (TE10) was treated with phosphorothioate antisense oligonucleotides to beta catenin. The cells were subsequently assayed for beta catenin mRNA and protein by real-time polymerase chain reaction and Western blot. Beta catenin transcriptional activity was determined by TOPFlash assay. Cell viability and growth was assessed by methyl-thiazol-diphenyl-tetrazolium assay and trypan blue exclusion. A colorimetric assay was employed to assess caspase 3 activity, and flow cytometry was done to determine percentage of cells in a given phase of the cell cycle.
Results: Following antisense treatment, beta catenin mRNA and protein concentration were decreased. There was corresponding decrease in beta catenin-transcription factor-dependent transcription. Treatment with beta catenin antisense resulted in significantly decreased cell viability and proliferation. The mechanism appears to be increased induction of apoptosis.
Conclusions: These data suggest a potential role for the targeting of beta catenin in the treatment of esophageal cancer.

DOI： 10.1016/j.jtcvs.2003.06.008

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記述言語：英語   掲載種別：研究論文（国際会議プロシーディングス）   出版者・発行元：Japanese Association for Thoracic Surgery  

Objectives: We evaluated the pre-, intra- and postoperative outcome of video-assisted thoracic surgery lobectomy in elderly lung cancer patients to determine what factors may be disadvantageous. Methods: From June 1982 to May 2000, 707 patients underwent pulmonary resection for primary lung cancer. Of these, 87 patients with t1-2 peripheral lung cancer underwent lobectomy and postoperative pulmonary function tests and postoperative conditions at an average of 2.3 months postoperatively. Of these, 52 underwent video-assisted thoracic surgery lobectomy since 1994 and 35 lobectomy by standard thoracotomy. Results: Video-assisted thoracic surgery lobectomy offered advantages in blood loss, chest wall damage, and minimal performance deterioration status. The percent vital capacity, percent forced expiratory in 1 second, and percent maximum ventilatory volume were well preserved in patients who underwent video-assisted thoracic surgery lobectomy. Multivariate logistic regression analysis identified operation duration as an independent risk factor in morbidity and operative procedure as an independent risk factor in performance deterioration. In stage IA and IB patients, 3-year-survival was 92.9% and 5-year survival 53.8% in those undergoing lobectomy by standard thoracotomy and 84.2% at 3 years and 60.1% at 5-years in those undergoing video-assisted thoracic surgery lobectomy. Conclusion: We thus consider video-assisted thoracic surgery lobectomy in this age group to be an effective procedure, but the long surgical duration is a risk factor in a poor clinical outcome.

DOI： 10.1007/BF02913481

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記述言語：英語  

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記述言語：日本語   出版者・発行元：日本医科大学医学会  

DOI： 10.1272/jnms.68.65

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

We analyzed the risk factors predisposing elderly patients to develop postoperative respiratory complications (PRCs) and investigated the possibility of predicting the postoperative pulmonary function and PRC rate. The postoperative pulmonary functions were predicted according to a simplified system, which we developed using plain chest roentgenograms from patients with primary lung cancer. Both univariate and multivariate analyses of PRCs were performed in 39 elderly patients with lung cancer from July 1982 to March 1991 (the early period). Based on the results obtained, the permissible extent of lung resection to achieve a predicted postoperative % forced expiratory volume in 1s (ppo%FEV1.0) and a predicted postoperative % vital capacity (ppo%VC) of more than 55% was selected as the basic criteria for undergoing such an operation after April 1991 (the recent period). A ppo%FEV1.0 and/or ppo%VC of 55% or less was the most significant risk factor for developing PRCs. The PRC rate decreased from 33.3% to 9.8% (P = 0.0251) and the operative mortality rate decreased from 10.3% to 0%. The survival rates for stage I, II, and III cases were not significantly different between the early and recent periods. Decisions made on the operability and the permissible extent of lung resection based on our system using plain chest roentgenograms therefore appeared to reduce the PRC rate and operative mortality rate in elderly patients.

DOI： 10.1007/s005950170023

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記述言語：日本語   出版者・発行元：日本肺癌学会  

症例は45歳の女性.主訴は胸部異常陰影であった.CT,気管支鏡等の精査の結果,腫瘍径2cmの良性悪性判定不能の肺腫瘍として当胸部外科紹介となり開胸術を施行した.術中所見で良性と考え核出術を試みたが,迅速診断にて腺癌との報告であったため,左下葉切除術に変更した一最終病理診断は,「Biphasic Pulmonary Blastoma」であった.本症例は臨床的には無症状かつ腫瘍径が小さいという特徴を有し,組織学的にはEmbryonal Carcinoma様の所見を認めたという点において特色を有していた.

DOI： 10.2482/haigan.39.339

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記述言語：日本語   出版者・発行元：日本医科大学医学会  

DOI： 10.1272/jnms.66.346

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記述言語：日本語   出版者・発行元：埼玉県医学会  

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1007/s005950050162

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記述言語：日本語   出版者・発行元：日本医科大学医学会  

DOI： 10.1272/jnms1923.65.481

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記述言語：日本語   出版者・発行元：Japanese College of Surgeons  

今回われわれは大腸内視鏡検査によりS状結腸穿孔を起こし, 開腹手術を行った潰瘍性大腸炎の1症例を経験したので報告する。症例は69歳の男性で, 粘血便, 下腹部痛のため入院, 全大腸型の潰瘍性大腸炎と診断された。保存的治療に抵抗し病期の確認のために大腸内視鏡検査を施行した。検査後から激烈な下腹部痛をきたし腹部単純X線写真で腹腔内遊離ガス像を認め, 結腸穿孔の診断のもと同日緊急開腹手術となった。S状結腸に5mm大の線状穿孔を認め, 同部をAlbert-Lembert縫合, 特にLembert縫合は穿孔部近傍の腹膜垂を漿膜に縫着するように行い, 穿孔を治癒せしめた。潰瘍性大腸炎のように大腸の炎症が強い場合, 大腸内視鏡検査による穿孔の危険は高まるものと考えられ, 十分注意して検査を進めるべきである。また, 穿孔部分が小さく, 腹腔内汚染も少なければ穿孔部分の縫合閉鎖で対処できると思われた。

DOI： 10.4030/jjcs1979.22.4_662

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記述言語：英語   掲載種別：研究論文（国際会議プロシーディングス）   出版者・発行元：MEDIMOND S R L  

For patients who were unable to undergo a lobectomy for small peripheral lung cancer. a partial resection was performed in an effort:to preserve as much lung parenchyma as possible.(1-7) However, since loco-regional recurrence could not be prevented by partial resection. this study was conducted to determine whether loco-regional recurrence could be reduced by means of concurrent internal radio-chemotherapy in the form of minimally invasive combined therapy (MICT). Eleven patients underwent MICT for stage I non-small cell lung cancer during the period from 1995 to 1996. Although a small number of patients were investigated and the follow-up period was short. 81 % of the MICT patients exhibited a one-year survival rate without recurrence and ten of ail exhibited good quality of life following MICT.

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記述言語：日本語   出版者・発行元：特定非営利活動法人 日本呼吸器外科学会  

DOI： 10.2995/jacsurg.11.449_3

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記述言語：日本語   出版者・発行元：特定非営利活動法人 日本呼吸器外科学会  

DOI： 10.2995/jacsurg.11.471_1

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記述言語：日本語   出版者・発行元：(NPO)日本肺癌学会  

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記述言語：日本語   出版者・発行元：(NPO)日本呼吸器外科学会  

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記述言語：日本語   出版者・発行元：(NPO)日本呼吸器外科学会  

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記述言語：日本語   出版者・発行元：(NPO)日本呼吸器外科学会  

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記述言語：日本語   出版者・発行元：(NPO)日本肺癌学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(NPO)日本呼吸器外科学会  

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記述言語：日本語   出版者・発行元：(NPO)日本呼吸器外科学会  

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記述言語：日本語   出版者・発行元：(NPO)日本呼吸器外科学会  

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記述言語：日本語   出版者・発行元：(NPO)日本肺癌学会  

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記述言語：日本語   出版者・発行元：(NPO)日本肺癌学会  

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記述言語：日本語   出版者・発行元：(NPO)日本肺癌学会  

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記述言語：日本語   出版者・発行元：(NPO)日本呼吸器外科学会  

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記述言語：日本語   出版者・発行元：(NPO)日本呼吸器外科学会  

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記述言語：日本語   出版者・発行元：日本胸部外科学会-関東甲信越地方会  

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記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）   出版者・発行元：ELSEVIER SCIENCE INC  

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記述言語：日本語   出版者・発行元：日本胸部外科学会-関東甲信越地方会  

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記述言語：日本語   出版者・発行元：(株)医学書院  

DOI： 10.11477/mf.1430200110

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記述言語：日本語   出版者・発行元：(NPO)日本肺癌学会  

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記述言語：日本語   出版者・発行元：(NPO)日本呼吸器外科学会  

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記述言語：日本語   出版者・発行元：日本胸部外科学会-関東甲信越地方会  

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記述言語：日本語   出版者・発行元：日本胸部外科学会-関東甲信越地方会  

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記述言語：日本語   出版者・発行元：(NPO)日本肺癌学会  

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記述言語：日本語   出版者・発行元：(NPO)日本肺癌学会  

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記述言語：日本語   出版者・発行元：(NPO)日本肺癌学会  

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記述言語：日本語   出版者・発行元：日本気胸・嚢胞性肺疾患学会  

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記述言語：日本語   出版者・発行元：(NPO)日本呼吸器内視鏡学会  

DOI： 10.18907/jjsre.37.Special_S298_3

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その他リンク： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2015&ichushi_jid=J00298&link_issn=&doc_id=20150521230434&doc_link_id=%2Fcf0brond%2F2015%2F0037s1%2F434%2F5298-5298%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fcf0brond%2F2015%2F0037s1%2F434%2F5298-5298%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

記述言語：日本語   出版者・発行元：日本外科系連合学会  

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記述言語：日本語   出版者・発行元：(NPO)日本呼吸器外科学会  

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記述言語：日本語   出版者・発行元：(NPO)日本呼吸器外科学会  

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記述言語：日本語   出版者・発行元：日本胸部外科学会-関東甲信越地方会  

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記述言語：日本語   出版者・発行元：(NPO)日本呼吸器内視鏡学会  

DOI： 10.18907/jjsre.37.1_120_4

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その他リンク： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2015&ichushi_jid=J00298&link_issn=&doc_id=20150213260057&doc_link_id=%2Fcf0brond%2F2015%2Fs03701%2F037%2F0120-0120%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fcf0brond%2F2015%2Fs03701%2F037%2F0120-0120%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

記述言語：日本語   出版者・発行元：(NPO)日本肺癌学会  

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記述言語：日本語   出版者・発行元：(NPO)日本肺癌学会  

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記述言語：日本語   出版者・発行元：日本胸部外科学会-関東甲信越地方会  

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記述言語：日本語   出版者・発行元：(NPO)日本呼吸器外科学会  

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記述言語：日本語   出版者・発行元：(NPO)日本呼吸器外科学会  

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記述言語：日本語   出版者・発行元：(NPO)日本呼吸器外科学会  

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記述言語：日本語   出版者・発行元：一般社団法人日本外科学会  

CiNii Books

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記述言語：日本語   出版者・発行元：(一社)日本呼吸器学会  

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記述言語：日本語   出版者・発行元：(一社)日本外科学会  

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記述言語：日本語   出版者・発行元：日本臨床外科学会  

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記述言語：日本語   出版者・発行元：(NPO)日本呼吸器外科学会  

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記述言語：日本語   出版者・発行元：(NPO)日本呼吸器外科学会  

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記述言語：日本語   出版者・発行元：(NPO)日本呼吸器外科学会  

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記述言語：日本語   出版者・発行元：(NPO)日本呼吸器外科学会  

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記述言語：日本語   出版者・発行元：特定非営利活動法人 日本小児外科学会  

DOI： 10.11164/jjsps.48.3_590_2

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記述言語：日本語   出版者・発行元：日本臨床外科学会  

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記述言語：日本語   出版者・発行元：(NPO)日本肺癌学会  

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記述言語：日本語   出版者・発行元：(NPO)日本肺癌学会  

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記述言語：日本語   出版者・発行元：日本外科系連合学会  

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記述言語：日本語   出版者・発行元：(NPO)日本呼吸器外科学会  

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記述言語：日本語   出版者・発行元：(NPO)日本肺癌学会  

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記述言語：日本語   出版者・発行元：(一社)日本内視鏡外科学会  

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記述言語：日本語   出版者・発行元：日本臨床外科学会  

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記述言語：日本語   出版者・発行元：日本臨床外科学会  

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記述言語：日本語   出版者・発行元：日本内科学会-関東地方会  

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記述言語：日本語   出版者・発行元：(一社)日本乳癌学会  

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記述言語：日本語   出版者・発行元：(NPO)日本呼吸器外科学会  

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記述言語：日本語   出版者・発行元：(NPO)日本呼吸器外科学会  

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記述言語：日本語   出版者・発行元：(NPO)日本呼吸器外科学会  

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記述言語：日本語   出版者・発行元：日本臨床外科学会  

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記述言語：日本語   出版者・発行元：日本臨床外科学会  

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記述言語：日本語   出版者・発行元：(一社)日本内視鏡外科学会  

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記述言語：日本語   出版者・発行元：日本臨床外科学会  

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記述言語：日本語   出版者・発行元：日本胸部外科学会-関東甲信越地方会  

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記述言語：日本語   出版者・発行元：日本胸部外科学会-関東甲信越地方会  

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記述言語：日本語   出版者・発行元：(NPO)日本肺癌学会  

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記述言語：日本語   出版者・発行元：日本臨床外科学会  

DOI： 10.3919/jjsa.70.839

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記述言語：日本語   出版者・発行元：日本臨床外科学会  

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記述言語：日本語   出版者・発行元：日本臨床外科学会  

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記述言語：日本語   出版者・発行元：(NPO)日本肺癌学会  

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記述言語：日本語   出版者・発行元：(NPO)日本呼吸器内視鏡学会  

DOI： 10.18907/jjsre.31.4_263_4

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その他リンク： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2009&ichushi_jid=J00298&link_issn=&doc_id=20090807340039&doc_link_id=%2Fcf0brond%2F2009%2F003104%2F043%2F0263-0263%26dl%3D2&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fcf0brond%2F2009%2F003104%2F043%2F0263-0263%26dl%3D2&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_5.gif

記述言語：日本語   出版者・発行元：(一社)日本サイトメトリー学会  

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記述言語：日本語   出版者・発行元：(一社)日本乳癌学会  

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記述言語：日本語   出版者・発行元：(NPO)日本呼吸器外科学会  

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記述言語：日本語   出版者・発行元：(NPO)日本呼吸器外科学会  

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記述言語：日本語   出版者・発行元：(NPO)日本呼吸器外科学会  

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記述言語：日本語   出版者・発行元：(NPO)日本心臓血管外科学会  

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記述言語：日本語   出版者・発行元：(一社)日本外科学会  

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記述言語：日本語   出版者・発行元：日本臨床外科学会  

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記述言語：日本語   出版者・発行元：日本臨床外科学会  

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記述言語：日本語   出版者・発行元：日本臨床外科学会  

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記述言語：日本語   出版者・発行元：(一社)日本内視鏡外科学会  

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記述言語：日本語   出版者・発行元：(一社)日本サイトメトリー学会  

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記述言語：日本語   出版者・発行元：(一社)日本呼吸器学会  

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記述言語：日本語   出版者・発行元：日本外科系連合学会  

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記述言語：日本語   出版者・発行元：(NPO)日本呼吸器外科学会  

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記述言語：日本語   出版者・発行元：(NPO)日本呼吸器外科学会  

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記述言語：日本語   出版者・発行元：(NPO)日本呼吸器外科学会  

DOI： 10.2995/jacsurg.22.426_4

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記述言語：日本語   出版者・発行元：日本気胸・嚢胞性肺疾患学会  

2002年1月〜2007年4月の難治性かつ間質性肺炎や肺気腫を合併した気胸症20例(男19例、女1例、年齢42〜86歳)を対象に手術適応について検討した。間質性肺炎合併5例、肺気腫合併15例であった。術前ドレナージ期間は6〜70日、術前癒着療法の施行は4例であった。胸腔鏡下手術は14例、小開胸術は6例で、術式は結紮術12例、胸膜剥離3例、ブラ縫縮術2例、縫合器使用2例、結紮術+縫合器使用1例であり、術後人工呼吸器使用は7例であった。術後合併症は間質性肺炎増悪1例、肺炎併発4例、肺瘻遷延1例、喘息発作1例で、術後死亡は3例あったが生存例における気胸再発は認めなかった。難治性気胸に対する治療は確立されておらず、治療にあたって留意すべきことは1.手術のタイミング、2.胸腔鏡下手術の優先、3.剥離困難や出血例には開胸手術、4.基本は気漏原因のブラ切除と縫縮、5.瘻孔部の処置可能な段階で剥離操作は留めて最小限とする、6.PGAシートなどの貼付、fibrin glue撒布、胸膜テントの併用で再発防止に努める、などであると考えた。

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記述言語：日本語   出版者・発行元：日本胸部外科学会-関東甲信越地方会  

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記述言語：日本語   出版者・発行元：(一社)日本内視鏡外科学会  

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記述言語：日本語   出版者・発行元：(NPO)日本呼吸器内視鏡学会  

DOI： 10.18907/jjsre.29.6_381_4

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記述言語：日本語   出版者・発行元：(一社)日本内視鏡外科学会  

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記述言語：日本語   出版者・発行元：日本臨床外科学会  

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記述言語：日本語   出版者・発行元：(NPO)日本肺癌学会  

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記述言語：日本語   出版者・発行元：(NPO)日本肺癌学会  

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記述言語：日本語   出版者・発行元：(NPO)日本肺癌学会  

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記述言語：日本語   出版者・発行元：(NPO)日本肺癌学会  

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記述言語：日本語   出版者・発行元：(NPO)日本肺癌学会  

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記述言語：日本語   出版者・発行元：(NPO)日本肺癌学会  

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記述言語：日本語   出版者・発行元：日本気胸・嚢胞性肺疾患学会  

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記述言語：日本語   出版者・発行元：(NPO)日本呼吸器内視鏡学会  

DOI： 10.18907/jjsre.29.4_262_3

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記述言語：日本語   出版者・発行元：日本胸部外科学会-関東甲信越地方会  

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記述言語：日本語   出版者・発行元：日本外科系連合学会  

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記述言語：日本語   出版者・発行元：日本外科系連合学会  

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記述言語：日本語   出版者・発行元：(NPO)日本肺癌学会  

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記述言語：日本語   出版者・発行元：(一社)日本サイトメトリー学会  

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記述言語：日本語   出版者・発行元：(NPO)日本呼吸器内視鏡学会  

DOI： 10.18907/jjsre.29.3_207_3

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記述言語：日本語   出版者・発行元：(NPO)日本呼吸器外科学会  

DOI： 10.2995/jacsurg.21.450_3

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記述言語：日本語   出版者・発行元：(NPO)日本呼吸器外科学会  

DOI： 10.2995/jacsurg.21.402_3

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記述言語：日本語   出版者・発行元：(NPO)日本呼吸器外科学会  

DOI： 10.2995/jacsurg.21.446_2

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記述言語：日本語   出版者・発行元：(NPO)日本呼吸器外科学会  

DOI： 10.2995/jacsurg.21.336_3

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記述言語：日本語   出版者・発行元：(一社)日本外科学会  

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記述言語：日本語   出版者・発行元：(一社)日本外科学会  

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記述言語：日本語   出版者・発行元：(一社)日本外科学会  

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記述言語：日本語   出版者・発行元：日本胸部外科学会-関東甲信越地方会  

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記述言語：日本語   出版者・発行元：(NPO)日本呼吸器内視鏡学会  

DOI： 10.18907/jjsre.29.1_69_1

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記述言語：日本語   出版者・発行元：(一社)日本内視鏡外科学会  

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記述言語：日本語   出版者・発行元：(一社)日本内視鏡外科学会  

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記述言語：日本語   出版者・発行元：(一社)日本内視鏡外科学会  

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記述言語：日本語   出版者・発行元：(NPO)日本肺癌学会  

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その他リンク： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2006&ichushi_jid=J01244&link_issn=&doc_id=20061120260652&doc_link_id=%2Fec7jaluc%2F2006%2F004605%2F650%2F0614-0614%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fec7jaluc%2F2006%2F004605%2F650%2F0614-0614%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

記述言語：日本語   出版者・発行元：(NPO)日本肺癌学会  

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記述言語：日本語   出版者・発行元：(NPO)日本肺癌学会  

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記述言語：日本語   出版者・発行元：(NPO)日本肺癌学会  

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記述言語：日本語   出版者・発行元：日本癌学会  

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記述言語：日本語   出版者・発行元：日本癌学会  

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記述言語：日本語   出版者・発行元：シュプリンガー・ジャパン(株)  

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記述言語：日本語   出版者・発行元：(NPO)日本呼吸器外科学会  

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記述言語：日本語   出版者・発行元：(NPO)日本肺癌学会  

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記述言語：日本語   出版者・発行元：(NPO)日本肺癌学会  

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記述言語：日本語   出版者・発行元：日本医科大学医学会  

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記述言語：日本語   出版者・発行元：(一社)日本循環器学会  

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記述言語：日本語   出版者・発行元：日本癌学会  

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記述言語：日本語   出版者・発行元：日本癌学会  

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記述言語：日本語   出版者・発行元：日本癌学会  

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記述言語：日本語   出版者・発行元：(NPO)日本呼吸器内視鏡学会  

症例)56歳 女性, 主訴)血痰, 現病歴)15年前より血疾症状の消退と再燃を繰り返し, 他院で精査するも診断に至らず経過観察となっていた. 平成17年2月始め頃より血痰出現し, 2週間以上軽快認めないため, 2/18当科外来受診した. 経過)入院にて胸部CT, 気管支鏡検査と併せて行った血管造影にて肺底区動脈大動脈起始症と診断に至った. この後, 当院肺外科転科し, 左肺下葉切除+異常肺動脈結紮切離術を行った. 肺分画症の定義は正常の肺組織から隔離された異常動脈により血液を供給されている異常肺組織とあり, 分類に肺葉内分画症, 肺葉外分画症がある. 今回の症例は肺葉内分画症の中のPryceの分類の異常血管は在るが分画肺がないとするType Iに相当するものであった. 今回我々は数年来の喀血を繰り返し, 当院で肺底区動脈大動脈起始症と確定診断した症例を経験した. 文献的考察とともに, 病理学的考察も併せて本症例を報告する.

DOI： 10.18907/jjsre.27.5_421_2

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記述言語：日本語   出版者・発行元：日本胸部外科学会-関東甲信越地方会  

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記述言語：日本語   出版者・発行元：日本胸部外科学会-関東甲信越地方会  

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記述言語：日本語   出版者・発行元：(NPO)日本呼吸器外科学会  

DOI： 10.2995/jacsurg.19.513_2

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記述言語：日本語   出版者・発行元：(NPO)日本呼吸器内視鏡学会  

DOI： 10.18907/jjsre.27.3_174_2

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記述言語：日本語   出版者・発行元：(NPO)日本呼吸器外科学会  

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その他リンク： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2005&ichushi_jid=J02256&link_issn=&doc_id=20050530300477&doc_link_id=10.2995%2Fjacsurg.19.436_1&url=https%3A%2F%2Fdoi.org%2F10.2995%2Fjacsurg.19.436_1&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

記述言語：日本語   出版者・発行元：日本胸部外科学会-関東甲信越地方会  

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記述言語：日本語   出版者・発行元：特定非営利活動法人 日本呼吸器内視鏡学会  

DOI： 10.18907/jjsre.27.3_174_2

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記述言語：日本語   出版者・発行元：日本胸部外科学会-関東甲信越地方会  

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記述言語：日本語   出版者・発行元：(NPO)日本呼吸器外科学会  

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その他リンク： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2004&ichushi_jid=J02256&link_issn=&doc_id=20040511120572&doc_link_id=10.2995%2Fjacsurg.18.437_1&url=https%3A%2F%2Fdoi.org%2F10.2995%2Fjacsurg.18.437_1&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

記述言語：英語   出版者・発行元：(一社)日本外科学会  

CiNii Books

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記述言語：日本語   出版者・発行元：(株)南江堂  

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記述言語：日本語   出版者・発行元：日本外科系連合学会  

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記述言語：日本語   出版者・発行元：(一社)日本呼吸器学会  

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記述言語：日本語   出版者・発行元：(NPO)日本肺癌学会  

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その他リンク： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2002&ichushi_jid=J01244&link_issn=&doc_id=20021114010604&doc_link_id=%2Fec7jaluc%2F2002%2F004205%2F605%2F0496-0496%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fec7jaluc%2F2002%2F004205%2F605%2F0496-0496%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

記述言語：日本語   出版者・発行元：シュプリンガー・ジャパン(株)  

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記述言語：日本語   出版者・発行元：シュプリンガー・ジャパン(株)  

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記述言語：日本語   出版者・発行元：シュプリンガー・ジャパン(株)  

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記述言語：日本語   出版者・発行元：(一社)日本サイトメトリー学会  

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記述言語：日本語   出版者・発行元：(一社)日本内視鏡外科学会  

1994年10月〜2000年9月に78例の原発性肺癌に対する胸腔鏡補助下肺葉切除を施行し,うち68例に縦隔リンパ節郭清を施行した.手術術式は小開胸と2〜3ヶ所のポートを使用し,胸腔鏡は30度の斜視を用いた.郭清には電気メス使用可の内視鏡用鋏刀,止血クリップ,超音波メスを使用した.平均縦隔郭清リンパ節個数は右肺癌で14.6個,左肺癌で8.6個であった.全体の5年生存率は75.1%で,左右別での5年生存率は右肺癌75.1%,左肺癌75.4%,病理病期IA+IB期は全体で88.0%,右肺癌は93.3%,左肺癌は84.8%であったが有意差を認めなかった.今回の対象症例では,左肺癌に対する#4リンパ節を除いて縦隔リンパ節郭清(ND2a)は安全に施行でき,予後も従来の定型的開胸術に相当する成績が得られ低侵襲手術の目的が達成されていると考えられた

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記述言語：日本語   出版者・発行元：一般社団法人日本外科学会  

CiNii Books

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記述言語：日本語   出版者・発行元：シュプリンガー・ジャパン(株)  

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記述言語：日本語   出版者・発行元：シュプリンガー・ジャパン(株)  

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記述言語：日本語   出版者・発行元：(一社)日本外科学会  

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記述言語：日本語   出版者・発行元：(一社)日本外科学会  

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記述言語：英語   出版者・発行元：(一社)日本サイトメトリー学会  

悪性腫瘍の中で特に乳癌は,欧米女性の8-10人に対して1人が生涯の間に罹患すると推測されており,日本においても最近増加傾向にある.手術新鮮標本にHER2/neu geneとchromosome 17 a satellite DNA probeを用いてdual color FISHをおこない乳癌とamplificationの関係を検討した.それらの結果から乳癌においてHER-2/neu amplificationは74%と高率に認められた

CiNii Books

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記述言語：日本語   出版者・発行元：(NPO)日本小児がん学会  

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記述言語：日本語   出版者・発行元：日本肺癌学会  

CiNii Books

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記述言語：日本語   出版者・発行元：シュプリンガー・ジャパン(株)  

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記述言語：日本語   出版者・発行元：(NPO)日本肺癌学会  

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記述言語：日本語   出版者・発行元：日本外科系連合学会  

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記述言語：日本語   出版者・発行元：(NPO)日本呼吸器外科学会  

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記述言語：日本語   出版者・発行元：(NPO)日本呼吸器外科学会  

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記述言語：日本語   出版者・発行元：一般社団法人日本外科学会  

CiNii Books

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記述言語：日本語   出版者・発行元：(一社)日本外科学会  

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記述言語：日本語   出版者・発行元：シュプリンガー・ジャパン(株)  

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記述言語：日本語   出版者・発行元：シュプリンガー・ジャパン(株)  

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記述言語：日本語   出版者・発行元：日本医科大学医学会  

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記述言語：日本語   出版者・発行元：シュプリンガー・ジャパン(株)  

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記述言語：日本語   出版者・発行元：シュプリンガー・ジャパン(株)  

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記述言語：日本語   出版者・発行元：(NPO)日本肺癌学会  

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記述言語：日本語   出版者・発行元：シュプリンガー・ジャパン(株)  

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記述言語：日本語   出版者・発行元：(NPO)日本肺癌学会  

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記述言語：日本語   出版者・発行元：(一社)日本サイトメトリー学会  

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記述言語：日本語   出版者・発行元：(NPO)日本呼吸器外科学会  

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記述言語：日本語   出版者・発行元：(NPO)日本呼吸器外科学会  

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記述言語：日本語   出版者・発行元：(NPO)日本呼吸器外科学会  

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記述言語：日本語   出版者・発行元：(NPO)日本呼吸器外科学会  

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記述言語：日本語   出版者・発行元：シュプリンガー・ジャパン(株)  

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記述言語：日本語   出版者・発行元：(一社)日本外科学会  

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記述言語：英語  

CiNii Books

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記述言語：日本語   出版者・発行元：(株)医学書院  

レゼクトスコープを用い5例8側に対し胸腔鏡下胸部交感神経節焼灼術を施行.対象は手掌多汗症3例6側,Buerger病2例2側で,手掌多汗症の3例6側は単一孔にて焼灼を行い,Buerger病2例のうち1例は胸腔内全面癒着がありミニ開胸を併用,他の1例は初期の症例で2個の操作孔(two puncture法)を用いて焼灼を施行.全症例において術中,術後の手術に関する合併症は認めなかった.術後疼痛は全例軽度であり,自覚症状の改善を全例にて認められた.ホルネル症候群の合併は1例もなかった

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記述言語：日本語   出版者・発行元：日本肺癌学会  

CiNii Books

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記述言語：日本語   出版者・発行元：(NPO)日本肺癌学会  

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記述言語：日本語   出版者・発行元：(NPO)日本肺癌学会  

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記述言語：日本語   出版者・発行元：日本肺癌学会  

CiNii Books

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記述言語：日本語   出版者・発行元：日本癌学会  

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記述言語：日本語   出版者・発行元：(一社)日本サイトメトリー学会  

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記述言語：日本語   出版者・発行元：(NPO)日本呼吸器外科学会  

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記述言語：日本語   出版者・発行元：(NPO)日本肺癌学会  

CiNii Books

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記述言語：日本語   出版者・発行元：日本肺癌学会  

CiNii Books

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記述言語：日本語   出版者・発行元：日本肺癌学会  

CiNii Books

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記述言語：日本語   出版者・発行元：日本肺癌学会  

CiNii Books

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記述言語：日本語   出版者・発行元：日本肺癌学会  

CiNii Books

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記述言語：日本語   出版者・発行元：日本肺癌学会  

CiNii Books

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記述言語：日本語   出版者・発行元：日本肺癌学会  

CiNii Books

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記述言語：日本語   出版者・発行元：日本肺癌学会  

CiNii Books

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記述言語：日本語   出版者・発行元：(NPO)日本肺癌学会  

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記述言語：日本語   出版者・発行元：日本肺癌学会  

CiNii Books

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記述言語：日本語   出版者・発行元：日本臨床外科学会  

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記述言語：日本語   出版者・発行元：(NPO)日本肺癌学会  

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記述言語：日本語   出版者・発行元：(NPO)日本呼吸器外科学会  

DOI： 10.2995/jacsurg.11.457_4

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記述言語：日本語   出版者・発行元：特定非営利活動法人 日本呼吸器外科学会  

DOI： 10.2995/jacsurg.11.325_1

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記述言語：日本語   出版者・発行元：日本肺癌学会  

DOI： 10.2482/haigan.39.339

CiNii Books

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記述言語：日本語   出版者・発行元：日本肺癌学会  

CiNii Books

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記述言語：日本語   出版者・発行元：社団法人日本循環器学会  

CiNii Books

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記述言語：日本語   出版者・発行元：(NPO)日本不整脈学会  

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記述言語：日本語   出版者・発行元：医学図書出版(株)  

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記述言語：日本語   出版者・発行元：日本臨床外科学会  

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記述言語：英語   会議種別：ポスター発表  

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記述言語：英語   会議種別：ポスター発表  

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記述言語：英語   会議種別：口頭発表（一般）  

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記述言語：英語   会議種別：ポスター発表  

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記述言語：英語   会議種別：口頭発表（一般）  

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記述言語：英語   会議種別：ポスター発表  

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記述言語：英語   会議種別：ポスター発表  

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記述言語：英語   会議種別：ポスター発表  

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