Updated on 2024/04/26

写真a

 
Kishi Yasuhiro
 
Affiliation
Musashikosugi Hospital, Department of Neuropsychiatry, Clinical Professor
Title
Clinical Professor
External link

Research Areas

  • Life Science / Psychiatry

Research History

Papers

  • Patient complexity, depression, and quality of life in patients with epilepsy at an epilepsy center in Japan. International journal

    Yasuiro Kishi, Ichiro Takumi, Hitoshi Yamamoto, Takako Ishimaru, Steven Thurber

    Epilepsia open   2022.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    OBJECTIVE: The relationship between care complexity and quality of life among patients with epilepsy has not been assessed, especially in Japan. The aim of this study is to test the hypothesis that care complexity is associated with health-related quality of life (HRQOL) and mood disturbance. METHOD: This was an observational cross-sectional study. The study included a consecutive series of 49 patients who newly visited an epilepsy center. Study participants were administered standardized quantitative measures of HRQOL, case complexity, and depression. RESULTS: Patient complexity predicted lower HRQL scores. Data on the social and psychological complexity domains predicted patient HRQOL findings more accurately than data from the biological domain of the case complexity scale. Seizure frequency was unrelated to HRQOL findings in this study. Additionally, depression scores were also associated with lower HRQOL. SIGNIFICANCE: A patient complexity assessment, including psychological and social domains, may be one of the key tools in epilepsy treatment settings. Further studies using larger random selection from patients with epilepsy are necessary to generalize the findings to patients in other epilepsy programs.

    DOI: 10.1002/epi4.12614

    PubMed

    researchmap

  • Does scoring patient complexity using COMPRI predict the length of hospital stay? A multicentre case-control study in Japan. International journal

    Daiki Yokokawa, Kiyoshi Shikino, Yasuhiro Kishi, Toshiaki Ban, Shigeyoshi Miyahara, Yoshiyuki Ohira, Yasutaka Yanagita, Yosuke Yamauchi, Yasushi Hayashi, Kosuke Ishizuka, Yuta Hirose, Tomoko Tsukamoto, Kazutaka Noda, Takanori Uehara, Masatomi Ikusaka

    BMJ open   12 ( 4 )   e051891   2022.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    OBJECTIVE: To clarify the factors associated with prolonged hospital stays, focusing on the COMplexity PRediction Instrument (COMPRI) score's accuracy in predicting the length of stay of newly hospitalised patients in general internal medicine wards. DESIGN: A case-control study. SETTING: Three general internal medicine wards in Chiba Prefecture, Japan. PARTICIPANTS: Thirty-four newly hospitalised patients were recruited between November 2017 and December 2019, with a final analytic sample of 33 patients. We included hospitals in different cities with general medicine outpatient and ward facilities, who agreed to participate. We excluded any patients who were re-hospitalised within 2 weeks of a prior discharge. PRIMARY AND SECONDARY OUTCOME MEASURES: Patients' COMPRI scores and their consequent lengths of hospital stay. RESULTS: The 17 patients (52%) allocated to the long-term hospitalisation group (those hospitalised ≥14 days) had a significantly higher average age, COMPRI score and percentage of participants with comorbid chronic illnesses than the short-term hospitalisation group (<14 days). A logistic regression model (model A, comprising only the COMPRI score as the explanatory variable) and a multiple logistic regression model (model B, comprising variables other than the COMPRI score as explanatory variables) were created as prediction models for the long-term hospitalisation group. When age ≥75 years, a COMPRI score ≥6 and a physician with 10 years' experience were set as explanatory variables, model A showed better predictive accuracy compared with model B (fivefold cross-validation, area under curve of 0.87 vs 0.78). The OR of a patient with a COMPRI score of ≥6 joining the long-term hospitalisation group was 4.25 (95% CI=1.43 to 12.63). CONCLUSIONS: Clinicians can use the COMPRI score when screening for complexity assessment to identify hospitalised patients at high risk of prolonged hospitalisation. Providing such patients with multifaceted and intensive care may shorten hospital stays.

    DOI: 10.1136/bmjopen-2021-051891

    PubMed

    researchmap

  • Translation and Cross-Cultural Adaptation of the Japanese Version of the INTERMED Self-Assessment Questionnaire (IMSA) for Patient-Case Complexity Assessment. International journal

    Daiki Yokokawa, Kiyoshi Shikino, Yasuhiro Kishi, Masatomi Ikusaka

    International journal of general medicine   15   6309 - 6313   2022

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Purpose: This study aims to translate and ensure cross-cultural adaptation of a Japanese version of the INTERMED Self-Assessment Questionnaire (IMSA). Methods: A family medicine physician, a medical education specialist, a psychiatrist who prepared the Japanese version of the INTERMED, and two members of the INTERMED consortium were selected as committee members. We used the standard forward and backward translation method to translate the IMSA into Japanese. After translating the original IMSA into Japanese, all committee members discussed and reached a consensus on the proposed translation. The back-translation was performed by an English native professional translator who did not know the original text. We contacted the INTERMED consortium and asked them to review the conceptual equivalence of the back-translated Japanese version with the original version; after two reviews, the members approved the Japanese version. Thereafter, we conducted cognitive debriefings with four patients and nine healthcare professionals to ensure cross-cultural adaptation. Results: The members of the INTERMED consortium approved the use of the Japanese version. We modified some expressions and words, while retaining the original meaning, to make it easier for Japanese patients to understand. Conclusion: We developed a Japanese version of the IMSA. A future study will investigate the construct criterion-related validity and the reliability of the scale.

    DOI: 10.2147/IJGM.S369056

    PubMed

    researchmap

  • 総合病院精神医学会におけるてんかん診療の現状・ニーズ調査(予備研究)

    谷口 豪, 井上 真一郎, 岩城 弘隆, 高木 俊輔, 倉持 泉, 朝山 健太郎, 辻富 基美, 本岡 大道, 岸 泰宏, 和田 健

    総合病院精神医学   33 ( Suppl. )   S - 186   2021.11

     More details

    Language:Japanese   Publisher:(一社)日本総合病院精神医学会  

    researchmap

  • 全国の精神保健福祉センターにおける自殺対策の取り組み 川崎市自殺未遂者支援地域連携モデルの実現可能性に関する調査

    竹島 正, 張 賢徳, 岸 泰宏, 高井 美智子, 廣田 菜津子, 橋本 貢河

    精神神経学雑誌   ( 2021特別号 )   S396 - S396   2021.9

     More details

    Language:Japanese   Publisher:(公社)日本精神神経学会  

    researchmap

  • 全国の精神保健福祉センターにおける自殺対策の取り組み 川崎市自殺未遂者支援地域連携モデルの実現可能性に関する調査

    竹島 正, 張 賢徳, 岸 泰宏, 高井 美智子, 廣田 菜津子, 橋本 貢河

    精神神経学雑誌   ( 2021特別号 )   S396 - S396   2021.9

     More details

    Language:Japanese   Publisher:(公社)日本精神神経学会  

    researchmap

  • せん妄の機序・病態の追求とそれに基づく発症予測・予防・治療方略 せん妄予防方略における睡眠覚醒サイクル障害と時間薬理学的アプローチ

    八田 耕太郎, 岸 泰宏, 和田 健, 竹内 崇, 橋本 直子, 須田 潔子, 平 俊浩, 土田 和生, 大森 隆史, 秋月 伸哉, 西尾 優子, 中西 幸子, 臼井 千恵, 倉田 明子, 堀川 直希, 江口 寛, 伊藤 滋朗, 武藤 仁志, 内村 直尚

    精神神経学雑誌   ( 2021特別号 )   S389 - S389   2021.9

     More details

    Language:Japanese   Publisher:(公社)日本精神神経学会  

    researchmap

  • コロナ禍における地域の自殺予防実践活動 自殺未遂者の地域支援活動 川崎市のモデル事業について

    高井 美智子, 竹島 正, 廣田 菜津子, 橋本 貢河, 植木 美津枝, 竹田 博子, 塚田 和広, 上原 嘉子, 伊藤 滋朗, 岸 泰宏, 玄 東和, 水野 康弘, 張 賢徳

    日本うつ病学会総会・日本認知療法・認知行動療法学会プログラム・抄録集   18回・21回   241 - 241   2021.7

     More details

    Language:Japanese   Publisher:日本うつ病学会・日本認知療法・認知行動療法学会  

    researchmap

  • 救急医がまず診る精神科救急患者の標準的対処法の学び方

    三宅 康史, 日野 耕介, 橋本 聡, 岸 泰宏, 大塚 耕太郎

    Journal of Japan Society of Neurological Emergencies & Critical Care   34 ( 1 )   24 - 24   2021.6

     More details

    Language:Japanese   Publisher:(株)へるす出版  

    researchmap

  • 日本サイコオンコロジー学会/日本サポーティブケア学会がん患者のせん妄ガイドライン第二版策定状況について

    貞廣 良一, 谷向 仁, 井上 真一郎, 松田 能宣, 稲田 修士, 岡本 禎晃, 角甲 純, 菅野 雄介, 岸 泰宏, 北浦 祐一, 菅野 康二, 竹内 麻理, 堂谷 知香子, 長谷川 貴昭, 原島 沙季, 平山 貴敏, 藤澤 大介, 吉村 匡史, 和田 佐保, 奥山 徹

    Palliative Care Research   15 ( Suppl. )   S591 - S591   2020.8

     More details

    Language:Japanese   Publisher:(NPO)日本緩和医療学会  

    researchmap

  • Impact of Behavioral Health Comorbidities on Health Care Costs Among Japanese Patients With Cancer. International journal

    Yasuhiro Kishi, Roger G Kathol, Yasuyuki Okumura

    Psychosomatics   2020.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND: Little is known about how behavioral health (BH) conditions affect health care costs of patients with cancer in Japan. OBJECTIVE: The purpose of this study is to evaluate the magnitude of general medical claims expenditures for individuals with cancer who use or do not use BH services in Japan. METHODS: The study used a health insurance claims database for more than 3 million enrollees in Japan. All health plan enrollees (18 y or older) who had tumors without metastasis or metastatic solid tumors defined by the Charlson Comorbidity Index were included in the study (n = 20,260). Measurements included total claims expenditures for BH and medical services. RESULTS: The proportion of enrollees using BH services was 12.8%. BH service users accounted for 17.7% of total health service spending. Mean annual cost of total health care services were 1.5 times higher in BH users than those with no BH use, whereas the median was 1.8 times higher. Mean annual medical cost alone for BH users was 1.3 times higher than that for non-BH users, whereas the median was 1.5 times higher. CONCLUSIONS: The findings suggest the importance for the Japanese medical system to address BH needs of patients with cancer and introduce fiscal efficiencies to cancer care. Strategic implementation of effective integrated care services for patients with cancer should be considered in Japan.

    DOI: 10.1016/j.psym.2020.06.008

    PubMed

    researchmap

  • General medical claims for behavioral health patients in Japan. International journal

    Yasuhiro Kishi, Roger G Kathol, Yasuyuki Okumura

    The American journal of managed care   26 ( 6 )   256 - 261   2020.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    OBJECTIVES: To evaluate the magnitude of general medical claims expenditures (ie, medical service use) for individuals who use and do not use behavioral health (BH) services in the Japanese free-access medical insurance system to determine if BH patients use substantially more health services, as has consistently been reported in the United States. STUDY DESIGN: Retrospective comparison of Japanese occupation-based total health services use for enrollees with and without comorbid BH conditions. METHODS: The study used a health insurance claims database for more than 3 million enrollees in Japan. All health plan enrollees (18 years and older) who had at least 1 diagnosis of a chronic medical condition were included in the study (N = 192,613). Measurements were total claims expenditures for BH and medical services. RESULTS: The proportion of enrollees using BH services was 14.3%. BH service users accounted for 21.1% of total health service spending. Annual total costs of BH service users were 1.6 times higher than those of non-BH users. Annual medical costs of BH users were 1.3 times higher than those of non-BH users. CONCLUSIONS: The results of this Japanese cohort study show that patients with concurrent BH conditions and chronic medical illnesses have substantially lower total health care costs than numerous studies have demonstrated in US populations. This is perhaps in part due to the integration of medical and BH claims payment and care delivery in Japan, an approach that the US health system may wish to consider testing.

    DOI: 10.37765/ajmc.2020.43488

    PubMed

    researchmap

  • JPOS/JASCC clinical guidelines for delirium in adult cancer patients: a summary of recommendation statements. International journal

    Yoshinobu Matsuda, Hitoshi Tanimukai, Shinichiro Inoue, Shuji Inada, Koji Sugano, Hideaki Hasuo, Masafumi Yoshimura, Saho Wada, Chikako Dotani, Hiroyoshi Adachi, Yoshiaki Okamoto, Mari Takeuchi, Daisuke Fujisawa, Jun Kako, Chiyuki Sasaki, Yasuhiro Kishi, Nobuya Akizuki, Masatoshi Inagaki, Yosuke Uchitomi, Eisuke Matsushima, Toru Okuyama

    Japanese journal of clinical oncology   50 ( 5 )   586 - 593   2020.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND: The Japanese Psycho-Oncology Society and Japanese Association of Supportive Care in Cancer recently launched the clinical practice guidelines for delirium in adult cancer patients. The aim of the guidelines was to provide evidence-based recommendations for the clinical assessment and management of delirium in cancer patients. This article reports the process of developing the guideline and summarizes the recommendations made. METHODS: The guidelines were developed in accordance with the Medical Information Network Distribution Service creation procedures. The guideline development group, consisting of multidisciplinary members, formulated nine clinical questions. A systematic literature search was conducted to identify relevant articles published prior to through 31 May 2016. Each article was reviewed by two independent reviewers. The level of evidence and the strength of the recommendations were graded using the grading system developed by the Medical Information Network Distribution Service, following the concept of The Grading of Recommendations Assessment, Development and Evaluation system. The modified Delphi method was used to validate the recommendation statements. RESULTS: This article provides a summary of the recommendations with rationales for each, as well as a short summary. CONCLUSIONS: These guidelines will support the clinical assessment and management of delirium in cancer patients. However, additional clinical studies are warranted to further improve the management of delirium.

    DOI: 10.1093/jjco/hyaa003

    PubMed

    researchmap

  • せん妄の新たな予防方略とその実効性を高める発症予測の研究展開 せん妄の新たな予防方略の展開とそのエビデンス Reviewed

    八田 耕太郎, 橋本 直子, 須田 潔子, 平 俊浩, 和田 健, 内村 直尚, 岸 泰宏, 竹内 崇, 土田 和生, 臼井 千恵, 秋月 伸哉, 西尾 優子, 中西 幸子, 倉田 明子, 堀川 直希, 江口 寛, 伊藤 滋朗, 武藤 仁志, 大森 隆史

    精神神経学雑誌   ( 2019特別号 )   S693 - S693   2019.6

     More details

    Language:Japanese   Publisher:(公社)日本精神神経学会  

    researchmap

  • Delirium Phenotype by Age and Sex in a Pooled Data Set of Adult Patients. Reviewed

    Trzepacz PT, Franco JG, Meagher DJ, Lee Y, Kim JL, Kishi Y, Furlanetto LM, Negreiros D, Huang MC, Chen CH, Kean J, Leonard M

    The Journal of neuropsychiatry and clinical neurosciences   appineuropsych18020024   2018.7

  • 過換気を主訴に救急受診となったくも膜下出血の一症例

    伊藤 滋朗, 岸 泰宏, 長谷川 智宏, 渡邉 顕弘, 望月 徹, 松田 潔

    総合病院精神医学   29 ( Suppl. )   S - 198   2017.11

     More details

    Language:Japanese   Publisher:(一社)日本総合病院精神医学会  

    researchmap

  • Preventive Effects of Suvorexant on Delirium: A Randomized Placebo-Controlled Trial Reviewed

    Kotaro Hatta, Yasuhiro Kishi, Ken Wada, Takashi Takeuchi, Shigeo Ito, Akiko Kurata, Kazunori Murakami, Manabu Sugita, Chie Usui, Hiroyuki Nakamura

    JOURNAL OF CLINICAL PSYCHIATRY   78 ( 8 )   E970 - +   2017.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:PHYSICIANS POSTGRADUATE PRESS  

    Objective: No highly effective pharmacologic interventions to prevent delirium have been identified. We examined whether suvorexant, a potent and selective orexin receptor antagonist, is effective for the prevention of delirium.
    Methods: We conducted a multicenter, rater-blinded, randomized, placebo-controlled clinical trial in intensive care units and regular acute wards between April 2015 and March 2016. Eligible patients were 65 to 89 years old, newly admitted due to emergency, and able to take medicine orally and had an expected stay or life expectancy of 48 hours or more. Seventy-two patients were randomly assigned using the sealed envelope method to receive suvorexant (15 mg/d; 36 patients) or placebo (36 patients) every night for 3 days. The primary outcome measure was incidence of delirium as determined by the DSM-5. Trained psychiatrists assessed for delirium.
    Results: We found that delirium developed significantly less often among patients taking suvorexant than among those taking placebo (0% [n/N = 0/36] vs 17% [6/36], respectively, P = .025). Comparison by log-rank test also showed that delirium developed significantly less often among patients taking suvorexant than among those taking placebo (chi(2) = 6.46, P = .011). Analysis of variance revealed a tendency for main effect of treatment (F = 3.79, P = .053) on the sleep-wake cycle disturbance score (item 1) of the Japanese version of the Delirium Rating Scale-Revised-98 (DRS-R-98-J). There were no significant differences in adverse events.
    Conclusions: Suvorexant administered nightly to elderly patients admitted for acute care may provide protection against delirium. Larger studies are needed to show the potential of suvorexant to improve the circadian core domain of delirium. (C) Copyright 2017 Physicians Postgraduate Press, Inc.

    DOI: 10.4088/JCP.16m11194

    Web of Science

    PubMed

    researchmap

  • Expert opinions on the first-line pharmacological treatment for delirium in Japan: a conjoint analysis Reviewed

    Yasuyuki Okumura, Kotaro Hatta, Ken Wada, Takashi Takeuchi, Yasuhiro Kishi

    INTERNATIONAL PSYCHOGERIATRICS   28 ( 6 )   1041 - 1050   2016.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:CAMBRIDGE UNIV PRESS  

    Background: There is little expert consensus as to which drugs should comprise the first-line pharmacological treatment for delirium. We sought to assess experts' opinions on the first-line oral and injection drugs for delirium associated with a diverse range of clinical features using a rating-based conjoint analysis.
    Methods: We conducted a cross-sectional study. We mailed a questionnaire to all consultation-liaison psychiatrists/educators certified by the Japanese Society of General Hospital Psychiatry.
    Results: Of 136 experts (response rate: 27.5%), more than 68% recommended the use of risperidone or quetiapine administered orally for hyperactive delirium, except in patients with comorbid diabetes and renal dysfunction. More than 67% recommended the use of haloperidol administered intravenously for hyperactive delirium if an intravenous line has been placed. No oral or injection drugs were recommended by over half of experts for treatment of hypoactive delirium with any clinical features.
    Conclusions: In the absence of a definitive treatment trial, there are both areas of agreement and a lack of consensus regarding the first-line drug. Efforts are needed to routinely collect information that would allow a comparison of the effectiveness and safety of various drugs in real-world clinical practice.

    DOI: 10.1017/S1041610215002446

    Web of Science

    PubMed

    researchmap

  • Ramelteon for Delirium in Hospitalized Patients Reviewed

    Kotaro Hatta, Yasuhiro Kishi, Ken Wada

    JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION   314 ( 10 )   1071 - 1072   2015.9

     More details

    Language:English   Publisher:AMER MEDICAL ASSOC  

    DOI: 10.1001/jama.2015.8522

    Web of Science

    PubMed

    researchmap

  • Using the INTERMED complexity instrument for a retrospective analysis of patients presenting with medical illness, substance use disorder, and other psychiatric illnesses Reviewed

    William Meller, Sheila Specker, Pam Schultz, Yasuhiro Kishi, Steven Thurber, Roger Kathol

    ANNALS OF CLINICAL PSYCHIATRY   27 ( 1 )   39 - 43   2015.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:QUADRANT HEALTHCOM INC  

    BACKGROUND: The financial and treatment challenges of complex patients must be addressed with adequate assessment and evaluation. The INTERMED complexity instrument (INTERMED) has been developed for this purpose, but to date has not been used retrospectively. The current study represents a retrospective validity investigation of INTERMED with patients with substance use disorder comorbid with other psychiatric and medical conditions (triple diagnoses). Such patients were expected to generate high complexity scores on the INTERMED instrument.
    METHODS: Information on 66 patients with triple diagnoses was submitted to the INTERMED complexity grid. These data were subjected to cluster analysis and other analytic procedures.
    RESULTS: Total INTERMED scores reflected elevated complexity for patients with triple diagnoses. As a group, they represented a single cluster of complex patients.
    CONCLUSIONS: The validity of the INTERMED complexity assessment was corroborated in relation to retrospective data. In addition to elevations in the biological domain that hospital personnel typically confront, findings related to coping deficiencies and problems in living conditions were noteworthy in requiring comprehensive interventions.

    Web of Science

    PubMed

    researchmap

  • Confirmatory factor analysis of the delirium rating scale revised-98 (DRS-r98) Reviewed

    Steven Thurber, Yasuhiro Kishi, Paula T. Trzepacz, Jose G. Franco, David J. Meagher, Yanghyun Lee, Jeong-Lan Kim, Leticia M. Furlanetto, Daniel Negreiros, Ming-Chyi Huang, Chun-Hsin Chen, Jacob Kean, Maeve Leonard

    Journal of Neuropsychiatry and Clinical Neurosciences   27 ( 2 )   e122 - e127   2015

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:American Psychiatric Association  

    Principal components analysis applied to the Delirium Rating Scale-Revised-98 contributes to understanding the delirium construct. Using a multisite pooled international delirium database, the authors applied confirmatory factor analysis to Delirium Rating Scale-Revised-98 scores from 859 adult patients evaluated by delirium experts (delirium, N=516
    nondelirium, N=343). Confirmatory factor analysis found all diagnostic features and core symptoms (cognitive, language, thought process, sleep-wake cycle, motor retardation), except motor agitation, loaded onto factor 1. Motor agitation loaded onto factor 2 with noncore symptoms (delusions, affective lability, and perceptual disturbances). Factor 1 loading supports delirium as a single construct, but when accompanied by psychosis, motor agitation’s role may not be solely as a circadian activity indicator.

    DOI: 10.1176/appi.neuropsych.13110345

    Scopus

    PubMed

    researchmap

  • What is integrated care? Reviewed

    Heather Huang, William Meller, Yasuhiro Kishi, Roger G. Kathol

    INTERNATIONAL REVIEW OF PSYCHIATRY   26 ( 6 )   620 - 628   2014.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:INFORMA HEALTHCARE  

    Increasing awareness of mental illness's impact on medical and psychiatric health has accelerated global efforts to integrate medical and behavioural health services. As the field of integration has advanced, numerous integrated programmes have been implemented. In examining the impact of these programmes, it is important to maintain a standardized vocabulary to describe the various components of their integration. Additionally important is examination of how these programmes impact elements of patient care and the healthcare system. Specifically, what value do they bring? This article will discuss the importance of carefully assessing the value integrated services bring to patients, and questioning whether they do so in ways in which today's segregated world of medical and behavioural health cannot. This article will also explore the various settings in which medical and behavioural integration can bring added value.

    DOI: 10.3109/09540261.2014.964189

    Web of Science

    PubMed

    researchmap

  • Outcomes after delirium in a Japanese intensive care unit Reviewed

    Takako Yamaguchi, Etsuko Tsukioka, Yasuhiro Kishi

    GENERAL HOSPITAL PSYCHIATRY   36 ( 6 )   634 - 636   2014.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER SCIENCE INC  

    Objective: Deliriumin the intensive care unit (ICU) is recognized as a major public health problem. Few Japanese outcome studies have been reported. The purpose of the study was to investigate the hospital outcomes of ICU delirium in a Japanese general hospital.
    Methods: Patients were drawn from consecutive admissions to an ICU at a tertiary care university hospital. Delirium assessments were conducted using the Intensive Care Delirium Screening Checklist (ICDSC). The following information was recorded: age, sex, the reason for ICU admission, the ICDSC scores, the COmplexity PRediction Instrument (COMPRI) scores, the length of stay (LOS) in the ICU, the total hospital LOS, hospital outcomes and social worker's consultation.
    Results: Of the 126 patients who were evaluated, 35 (27.8%) developed delirium during the ICU stay. Older age and biopsychosocial vulnerability assessed by the COMPRI were risk factors of ICU delirium. ICU delirium was a predictor of increased mortality and associated with prolonged ICU and hospital LOS. ICU delirium was an independent risk factor for having social worker's consultation after ICU discharge.
    Conclusions: ICU delirium is associated with worse outcomes including mortality and LOS in Japan. ICU delirium is independently associated with further social worker's consultations, suggesting that early proactive social worker's intervention may be beneficial for the patients with ICU delirium. (C) 2014 Elsevier Inc. All rights reserved.

    DOI: 10.1016/j.genhosppsych.2014.09.006

    Web of Science

    PubMed

    researchmap

  • Can quick first step bio-psycho-social screening, COMPRI (COMplexity PRediction Instrument), predict length of hospital stay in a general hospital in Japan? Reviewed

    Yasuhiro Kishi, Yuri Hazama, Yumika Komagata, Minato Karube, Junko Takahashi

    JOURNAL OF PSYCHOSOMATIC RESEARCH   77 ( 4 )   330 - 331   2014.10

     More details

    Language:English   Publisher:PERGAMON-ELSEVIER SCIENCE LTD  

    DOI: 10.1016/j.jpsychores.2014.06.018

    Web of Science

    PubMed

    researchmap

  • Preventive Effects of Ramelteon on Delirium A Randomized Placebo-Controlled Trial Reviewed

    Kotaro Hatta, Yasuhiro Kishi, Ken Wada, Takashi Takeuchi, Toshinari Odawara, Chie Usui, Hiroyuki Nakamura

    JAMA PSYCHIATRY   71 ( 4 )   397 - 403   2014.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:AMER MEDICAL ASSOC  

    IMPORTANCE No highly effective interventions to prevent delirium have been identified.
    OBJECTIVE To examine whether ramelteon, a melatonin agonist, is effective for the prevention of delirium.
    DESIGN, SETTING, AND PARTICIPANTS A multicenter, rater-blinded, randomized placebo-controlled trial was performed in intensive care units and regular acute wards of 4 university hospitals and 1 general hospital. Eligible patients were 65 to 89 years old, newly admitted due to serious medical problems, and able to take medicine orally. Patients were excluded from the study if they had an expected stay or life expectancy of less than 48 hours.
    INTERVENTIONS Sixty-seven patients were randomly assigned using the sealed envelope method to receive ramelteon (8 mg/d; 33 patients) or placebo (34 patients) every night for 7 days.
    MAIN OUTCOMES AND MEASURES Incidence of delirium, as defined by the Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition).
    RESULTS Ramelteon was associated with a lower risk of delirium (3% vs 32%; P = .003), with a relative risk of 0.09 (95% CI, 0.01-0.69). Even after risk factors were controlled for, ramelteon was still associated with a lower incidence of delirium (P =.01; odds ratio, 0.07 [95% CI, 0.008-0.54]). The Kaplan-Meier estimates of time to development of delirium were 6.94 (95% CI, 6.82-7.06) days for ramelteon and 5.74 (5.05-6.42) days for placebo. Comparison by log-rank test showed that the frequency of delirium was significantly lower in patients taking ramelteon than in those taking placebo (X-2 = 9.83; P =.002).
    CONCLUSIONS AND RELEVANCE Ramelteon administered nightly to elderly patients admitted for acute care may provide protection against delirium. This finding supports a possible pathogenic role of melatonin neurotransmission in delirium.

    DOI: 10.1001/jamapsychiatry.2013.3320

    Web of Science

    PubMed

    researchmap

  • Coefficient Alpha and Interculture Test Selection Reviewed

    Steven Thurber, Yasuhiro Kishi

    ASSESSMENT   21 ( 2 )   250 - 252   2014.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:SAGE PUBLICATIONS INC  

    The internal consistency reliability of a measure can be a focal point in an evaluation of the potential adequacy of an instrument for adaptation to another cultural setting. Cronbach's alpha (alpha) coefficient is often used as the statistical index for such a determination. However, alpha presumes a tau-equivalent test and may constitute an inaccurate population estimate for multidimensional tests. These notions are expanded and examined with a Japanese version of a questionnaire on nursing attitudes toward suicidal patients, originally constructed in Sweden using the English language. The English measure was reported to have acceptable internal consistency (alpha) albeit the dimensionality of the questionnaire was not addressed. The Japanese scale was found to lack tau-equivalence. An alternative to alpha, "composite reliability," was computed and found to be below acceptable standards in magnitude and precision. Implications for research application of the Japanese instrument are discussed.

    DOI: 10.1177/1073191112444921

    Web of Science

    PubMed

    researchmap

  • Antipsychotics for delirium in the general hospital setting in consecutive 2453 inpatients: a prospective observational study Reviewed

    Kotaro Hatta, Yasuhiro Kishi, Ken Wada, Toshinari Odawara, Takashi Takeuchi, Takafumi Shiganami, Kazuo Tsuchida, Yoshio Oshima, Naohisa Uchimura, Rie Akaho, Akira Watanabe, Toshihiro Taira, Katsuji Nishimura, Naoko Hashimoto, Chie Usui, Hiroyuki Nakamura

    INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY   29 ( 3 )   253 - 262   2014.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY-BLACKWELL  

    ObjectiveAttention to risk of antipsychotics for older patients with delirium has been paid. A clinical question was whether risk of antipsychotics for older patients with delirium would exceed efficacy of those even in the general hospital setting.
    MethodsA prospective observational study proceeded over a 1-year period at 33 general hospitals, where at least one psychiatrist worked full time. Subjects were patients who developed delirium during their admission due to acute somatic diseases or surgery, and who received antipsychotics for delirium. The primary outcome was rates and kinds of serious adverse events.
    ResultsAmong 2834 patients who developed delirium, 2453 patients received antipsychotics, such as risperidone (34%), quetiapine (32%), and parenteral haloperidol (20%), for delirium. Out of 2453 patients, 22 serious adverse events (0.9%) were reported. Aspiration pneumonia was the most frequent (17 patients, 0.7%), followed by cardiovascular events (4 patients, 0.2%) and venous thromboembolism (1 patient, 0.0%). There was no patient with a fracture or intracranial injury due to a fall. No one died because of antipsychotic side effects. The mean Clinical Global ImpressionsImprovement Scale score was 2.02 (SD 1.09). Delirium was resolved within 1week in more than half of the patients (54%).
    ConclusionsIn the general hospital setting under management including fine dosage adjustment and early detection of side effects, risk of antipsychotics for older patients with delirium might be low, in contrast to antipsychotics for dementia in the nursing home or outpatient settings. A point may be not how to avoid using antipsychotics but how to monitor their risk. (c) 2013 The Authors. International Journal of Geriatric Psychiatry published by John Wiley & Sons, Ltd.

    DOI: 10.1002/gps.3999

    Web of Science

    PubMed

    researchmap

  • The predictive value of a change in natural killer cell activity for delirium Reviewed

    Kotaro Hatta, Yasuhiro Kishi, Takashi Takeuchi, Ken Wada, Toshinari Odawara, Chie Usui, Yutaka Machida, Hiroyuki Nakamura

    PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY   48   26 - 31   2014.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:PERGAMON-ELSEVIER SCIENCE LTD  

    Purpose: Few studies looking for an effective biomarker to predict delirium have been performed. This study was designed to investigate whether a change in inflammatory status, indicated by blood natural killer (NK) cell activity, predicts delirium.
    Methods: This prospective study, performed in 4 university and 1 general hospital from September, 2011 to October, 2012, included 29 patients. Eligible patients were 65-89 years old, newly and emergently admitted. Patients were assessed daily, up to 7 days, for occurrence of DSM-IV-defined delirium. The main outcome measure was change in blood NK cell activity between the first and second mornings after admission.
    Results: The mean change in blood NK cell activity on the second morning, compared to the first morning, in patients developing delirium (n = 9) was significantly greater than that in patients without delirium (n = 20) (6.0% [SD 8.4] vs. -1.4% [9.0], respectively, t = 2.10, P = 0.045). Significant difference between the groups was still found after adjusting for age, the history of previous delirium, and the Clinical Dementia Rating score (F = 6.63, P = 0.017). Of note is that 8 of 9 (89%) patients developing delirium had increased blood NK cell activity, as did only 8 of 20 (40%) patients without delirium, giving measurement of this parameter, for distinguishing the two groups, a sensitivity of 89%, specificity 60%, positive predictive value 50%, negative predictive value 92%, positive likelihood ratio 2.22, and negative likelihood ratio 0.19. When combining this predictor with another predictor, a Delirium Rating Scale-Revised-98 severity score of 5 or more at baseline, positive and negative likelihood ratios were 7.80 and 0.24, respectively.
    Conclusion: Increase in blood NK cell activity may be associated with developing delirium. Further studies including larger numbers of patients are needed to justify the preventive use of drugs for patients meeting criteria for both predictors. (C) 2013 The Authors. Published by Elsevier Inc. All rights reserved.

    DOI: 10.1016/j.pnpbp.2013.09.008

    Web of Science

    PubMed

    researchmap

  • DIAGNOSES OF PSYCHIATRIC DISORDERS IN HYPOTHETICAL PATIENTS BY NON-PSYCHIATRIC PHYSICIANS IN JAPAN Reviewed

    Yasuhiro Kishi, Hisashi Kurosawa, Naoshi Horikawa, Kotaro Hatta, William Meller

    INTERNATIONAL JOURNAL OF PSYCHIATRY IN MEDICINE   47 ( 1 )   65 - 74   2014

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:SAGE PUBLICATIONS INC  

    Objective: This study was undertaken to investigate non-psychiatric physicians' diagnoses of hypothetical patients in clinical scenarios with comorbid medical and psychiatric disease in Japan. Methods: The non-psychiatric physicians were asked to diagnose eight clinical scenarios describing several typical behavioral health problems in the medical settings. Results: A total of 155 non-psychiatric physicians participated. Many physicians had problems correctly diagnosing depression and hypoactive delirium with medically ill patients. Conclusions: It is time to incorporate new efficient and effective approaches, such as collaborative care system and proactive delirium prevention programs, to improve overall behavioral health diagnosis and treatment, rather than relying on the rapid recognition of behavioral health problems in primary care/general medical settings.

    DOI: 10.2190/PM.47.1.f

    Web of Science

    PubMed

    researchmap

  • Effects of a training workshop on suicide prevention among emergency room nurses. Reviewed International journal

    Yasuhiro Kishi, Kotaro Otsuka, Keiko Akiyama, Tomoki Yamada, Yumiko Sakamoto, Yaeko Yanagisawa, Hiroshi Morimura, Chiaki Kawanishi, Hiroaki Higashioka, Yasushi Miyake, Steven Thurber

    Crisis   35 ( 5 )   357 - 61   2014

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND: Suicide attempts are frequently encountered by emergency department nurses. Such encounters can potentially provide a foundation for secondary suicide prevention. AIMS: The aim of the present investigation was to evaluate the effect of a 7-hr training program for emergency room nursing personnel in Japan. METHOD: In all, 52 nurses completed the questionnaires before the workshop and 1 month after the workshop. The nurses' understanding of and willingness to care for suicidal patients positively changed. RESULTS: It is feasible to provide a 7-hr, relatively short, workshop on suicidal prevention aimed at emergency medical staff and to improve attitudes during a follow-up of 1 month. CONCLUSION: It is uncertain whether the positive attitudes of emergency nurses toward suicide and/or educational interventions could impact the outcomes of these interventions. Further studies are needed to address these important questions in this field.

    DOI: 10.1027/0227-5910/a000268

    PubMed

    researchmap

  • [Delirium]. Reviewed

    Kishi Y

    Nihon rinsho. Japanese journal of clinical medicine   71 ( 10 )   1738 - 1742   2013.10

     More details

  • Three Core Domains of Delirium Validated Using Exploratory and Confirmatory Factor Analyses Reviewed

    Jose G. Franco, Paula T. Trzepacz, David J. Meagher, Jacob Kean, Yanghyan Lee, Jeong-Lan Kim, Yasuhiro Kishi, Leticia M. Furlanetto, Daniel Negreiros, Ming-Chyi Huang, Chun-Hsin Chen, Maeve Leonard, Joan de Pablo

    PSYCHOSOMATICS   54 ( 3 )   227 - 238   2013.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER SCIENCE INC  

    Objective: To confirm the existence of the proposed three-core symptom domains in delirium by analyzing a dataset of nondemented adults using selected core symptoms as measured by the Delirium Rating Scale-Revised-98 (DRS-R98) scale. Methods: Exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) of proposed delirium core symptoms were conducted in a pooled international dataset of 592 delirious and nondelirious patients using DSM-IV criteria from 14 studies with comparable methodologies. Using DRS-R98 categorization, 445 had either subsyndromal or full delirium and comprised the delirium group. The dataset was divided into three independent random subsamples to perform a stepwise analysis. First we performed EFA in 100 cases to delineate latent factor loadings of DRS-R98 items selected to represent the three-core domains (circadian, higher level thinking, and cognitive). These items were then assessed using CFA-modeling (n = 246) followed by a CFA-validation (n = 246). Reliability and goodness of fit of these two CFA were assessed statistically. Results: DRS-R98 items representing the proposed delirium core symptoms loaded onto one factor in the EFA, supporting their core nature. The two CFA confirmed the nature of this core factor as comprising three core domains where DRS-R98 items each loaded with high values (&gt;0.7) onto their corresponding core domain (circadian, higher level thinking, and cognitive) with good fit and reliability). Attention was DRS-R98 item with the highest loading in CFA, followed by thought process, and then by sleep-wake cycle and motor behavior. Conclusions: Our EFA and CFA confirm and validate the proposed three-core domains of delirium, where symptoms were highly related to the domain that they were hypothesized to represent. These domains are consistent with delirium being a state of impaired consciousness, and should be considered necessary to assess whether in clinical or research settings.

    DOI: 10.1016/j.psym.2012.06.010

    Web of Science

    PubMed

    researchmap

  • Training workshop on caring for suicide attempters implemented by the Ministry of Health, Labour and Welfare, Japan Reviewed

    Maki Hirata, Chiaki Kawanishi, Nene Oyama, Yasushi Miyake, Kotaro Otsuka, Tomoki Yamada, Yasuhiro Kishi, Hiroto Ito, Ryousuke Arakawa

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   67 ( 1 )   64 - 64   2013.1

     More details

    Language:English   Publisher:WILEY-BLACKWELL  

    DOI: 10.1111/pcn.12004

    Web of Science

    PubMed

    researchmap

  • Treatment of delirium with risperidone in cancer patients Reviewed

    Yasuhiro Kishi, Masashi Kato, Toru Okuyama, Steven Thurber

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   66 ( 5 )   411 - 417   2012.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY  

    Aim: Antipsychotic medications have frequently been regarded as the treatment of choice for delirium. This study examined the clinical efficacy of risperidone for the treatment of delirium in cancer patients, combined with a repeated assessment of underlying medical severity levels. Methods: The study included consecutive referrals of 29 delirious cancer patients (mean age, 68.9 +/- 12.5 years; male, 69%) to the psychiatric consultation service. Risperidone was given orally once per day (mean dosage, 1.4 +/- 1.3 mg/day). Study participants were assessed using quantitative standardized scales of cognitive function, delirium, and physical impairment at baseline and at the end of the study (seventh day). Results: Risperidone with routine clinical management was effective for the treatment of delirium: 48% of the patients responded and 38% achieved remission. The reduction of delirium severity occurred in 79% of the patients. Changes in delirium severity were unrelated to age, gender, general cognitive dysfunction, or to severity of attendant medical conditions. In addition to changes in agitation and perceptional disturbances, risperidone was also effective for other specific delirium symptoms. Conclusions: Risperidone with routine clinical management is effective in the treatment of delirium in advanced cancer patients, independent of changes in the underlying medical condition.

    DOI: 10.1111/j.1440-1819.2012.02346.x

    Web of Science

    PubMed

    researchmap

  • Preferences of help regarding behavioral health problems among the Japanese general population Reviewed

    Yasuhiro Kishi, Hisashi Kurosawa, Naoshi Horikawa, Kotaro Hatta, William Meller

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   66 ( 5 )   460 - 461   2012.8

     More details

    Language:English   Publisher:WILEY-BLACKWELL  

    DOI: 10.1111/j.1440-1819.2012.02369.x

    Web of Science

    PubMed

    researchmap

  • Phenotype of subsyndromal delirium using pooled multicultural Delirium Rating Scale Revised-98 data Reviewed

    Paula T. Trzepacz, Jose G. Franco, David J. Meagher, Yanghyun Lee, Jeong-Lan Kim, Yasuhiro Kishi, Leticia M. Furlanetto, Daniel Negreiros, Ming-Chyi Huang, Chun-Hsin Chen, Jacob Kean, Maeve Leonard

    JOURNAL OF PSYCHOSOMATIC RESEARCH   73 ( 1 )   10 - 17   2012.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:PERGAMON-ELSEVIER SCIENCE LTD  

    Objective: There is no consensus definition for the phenotype of subsyndromal delirium (SSD), a subthreshold state to full delirium. Without an a priori definition we applied advanced analytic techniques to discern SSD.
    Method: We pooled Delirium Rating Scale Revised-98 (DRS-R98) data from 859 DSM-IV diagnosed nondemented delirious adults and nondelirious controls collected by investigators in 7 countries. Discriminant analyses defined an SSD group that was then compared to Nondelirium and Delirium groups.
    Results: SSD (n = 138) had intermediate DRS-R98 item seventies between Delirium (n = 497) and Nondelirium (n = 224) groups, where groups significantly differed on all DRS-R98 items (ANOVA p&lt;.001) except delusions. Discriminant analysis found SSD phenomenologically closer to Delirium than Nondelirium. Using full multinomial logistical regression, SSD was distinguished from Nondelirium by temporal onset, sleep-wake cycle, perceptual disturbances, motor retardation, delusion, affective lability, and all cognitive items; SSD was similar to Delirium in thought process, language, motor agitation or retardation, sleep-wake cycle, all cognitive items, fluctuation and physical disorder. The multivariate model correctly classified 94.2% of Nondelirium, 75.4% of SSD and 97.2% of Delirium subjects. Binary logistic regression of six core domain symptoms (sleep-wake cycle, thought process, language, attention, orientation, and visuospatial ability) together were found as highly differentiating of SSD from Nondelirium, which correctly classified almost 80% of SDD.
    Conclusions: SSD is intermediate in severity between nondelirious controls and full syndromal delirium, but its phenotype is more like delirium. Core domain delirium symptoms present at milder severity in SSD should be evaluated further for utility in detecting and managing SSD, preventing delirium, and possible inclusion in DSM-V. (C) 2012 Elsevier Inc. All rights reserved.

    DOI: 10.1016/j.jpsychores.2012.04.010

    Web of Science

    PubMed

    researchmap

  • Attitudes of Japanese nursing personnel toward patients who have attempted suicide Reviewed

    Yasuhiro Kishi, Hisashi Kurosawa, Hiroshi Morimura, Kotaro Hatta, Steven Thurber

    GENERAL HOSPITAL PSYCHIATRY   33 ( 4 )   393 - 397   2011.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER SCIENCE INC  

    Objective: The aim of this study was to examine the attitudes among Japanese nurses together with their perceived need for training in relation to understanding the nature of suicidal behavior and preventive strategies.
    Methods: The Understanding Suicidal Patients scale together with additional questions reflecting training and the psychiatric treatment of suicide attempters were administered.
    Results: A total of 323 nurses attended this study. Overall, the nurses thought patients who attempted suicide were not treated well. The nurses who worked in the psychiatric unit or had the experience in psychiatric nursing had more favorable attitudes toward suicidal patients and viewed themselves as having more relevant skill training in dealing with suicidal patients than those who did not. The nurses who worked at emergency care/intensive care unit were less likely to understand suicidal patients, and were less inclined to be sympathetic and to verbally interact with suicidal patients concerning their problems. The nurses who have confidence in the psychiatric care of suicidal patients, confidence in their own skills, and have a need for more training had the more positive attitudes.
    Conclusions: The results suggest that less favorable attitudes may to some extent be the result of lack of knowledge regarding suicidal patients. Future studies should focus on the evaluation of educational experiences on attitudes and skill acquisition of nurses. (C) 2011 Elsevier Inc. All rights reserved.

    DOI: 10.1016/j.genhosppsych.2011.02.005

    Web of Science

    PubMed

    researchmap

  • The INTERMED Japanese version: Inter-rater reliability and internal consistency Reviewed

    Yasuhiro Kishi, Maki Matsuki, Hidetoshi Mizushima, Hideyuki Matsuki, Yukiko Ohmura, Naoshi Horikawa

    JOURNAL OF PSYCHOSOMATIC RESEARCH   69 ( 6 )   583 - 586   2010.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:PERGAMON-ELSEVIER SCIENCE LTD  

    Objective: The intent of this study was to establish the inter-rater reliability and the internal consistency of the Japanese version of the INTERMED. Methods: The study included a series of patients referred to psychiatric consultation service or palliative care service. The study participants were independently scored using the INTERMED by the raters. Results: The INTERMED-Japanese version had high inter-rater reliability (intraclass correlation coefficient=0.98) and high internal consistency (alpha=.89). All four domains (biological, psychological, social, and health care domains) were positively correlated. Based on a cutoff score of 20/21, a kappa of 0.79 was found. Conclusions: The INTERMED is an easy and useful proactive biopsychosocial screening tool, which could be a reasonable utility under the current Japanese health care situations. Future studies focusing on the INTERMED utility in improving health care delivery for patients with complex biopsychosocial care needs has to be demonstrated in various medical settings in Japan. (C) 2010 Elsevier Inc. All rights reserved.

    DOI: 10.1016/j.jpsychores.2010.02.006

    Web of Science

    PubMed

    researchmap

  • Japanese Version of the Delirium Rating Scale, Revised-98 (DRS-R98-J): Reliability and Validity Reviewed

    Masashi Kato, Yasuhiro Kishi, Toru Okuyama, Paula T. Trzepacz, Takashi Hosaka

    PSYCHOSOMATICS   51 ( 5 )   425 - 431   2010.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:AMER PSYCHIATRIC PUBLISHING, INC  

    Background: Delirium is a common neuropsychiatric disorder in medical and surgical inpatients of all ages. It is associated with increased long-term mortality, longer length of hospital stay, poor functional recovery, and increased likelihood of nursing home placement. Objective: The aim of this study was to investigate the reliability and the validity of the Japanese translation of the Delirium Rating Scale, Revised-98 (DRS-R-98). Method: Psychiatric-consultation patients were assessed to compare groups of delirium, dementia, and non-delirium. Results: Mean Total and Severity scores significantly distinguished delirium from the other groups. The scale had high interrater reliability and high internal consistency. Mean Severity scores during delirium differed from the posttreatment scores. Stratum-specific likelihood ratios showed that the DRS-R98-J is a reliable diagnostic tool. Conclusion: This study indicates that the Japanese version of the DRS-R-98 has high reliability and validity, and is a useful tool for assessing delirium among Japanese medically ill populations. (Psychosomatics 2010; 51: 425-431)

    DOI: 10.1176/appi.psy.51.5.425

    Web of Science

    PubMed

    researchmap

  • [The current state and further development of consultation-liaison psychiatry in general hospitals]. Reviewed

    Kishi Y

    Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica   112 ( 12 )   1203 - 1209   2010

     More details

  • Frequency and clinical features of pervasive developmental disorder in adolescent suicide attempts Reviewed

    Katsunaka Mikami, Seiji Inomata, Noriyoshi Hayakawa, Yuichi Ohnishi, Yoichi Enseki, Akitoshi Ohya, Yasuo Haruki, Yasuhiro Kishi, Yutaka Shinohara, Atsushi Ichimura, Hideo Matsumoto

    GENERAL HOSPITAL PSYCHIATRY   31 ( 2 )   163 - 166   2009.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER SCIENCE INC  

    Objective: The goal of this clinical study was to examine the frequency and clinical features of pervasive developmental disorder (PDD) relative to suicide attempts by adolescents.
    Method: Ninety-four adolescent patients tinder age 20 participated in this study; it was a consecutive study of individuals who had attempted suicide and had been hospitalized for inpatient treatment.
    Results: Twelve of the 94 subjects (12.8%) were diagnosed with PDD. The ratio of males in the PDD group was higher than that in the non-PDD group (P=.017). There was a significant difference between the two groups regarding the rate of patients having mood or anxiety disorder (P=.037).
    Conclusion: This study indicates that PDD should always be a consideration when dealing with adolescent suicide attempts. (C) 2009 Elsevier Inc. All rights reserved.

    DOI: 10.1016/j.genhosppsych.2008.12.003

    Web of Science

    PubMed

    researchmap

  • Medical and psychiatric comorbidity in psychiatric beds in general hospitals: A cross-sectional study in Tokyo Reviewed

    Kotaro Hatta, Hiroyuki Nakamura, Chie Usui, Takafumi Kobayashi, Yoshito Kamijo, Toyoaki Hirata, Shuichi Awata, Yasuhiro Kishi, Heii Arai, Hisashi Kurosawa

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   63 ( 3 )   329 - 335   2009

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY-BLACKWELL PUBLISHING, INC  

    Aims: Although somatic diseases in psychiatric patients are increasing with the increase of the aged population, psychiatric wards in general hospitals in Japan have progressively been decreasing. The purpose of this cross-sectional study was to clarify whether psychiatric beds in general hospitals play sufficient roles in medical comorbidities of psychiatric patients or not.
    Methods: This was a cross-sectional study performed all over Tokyo during the 2-month period from April to May 2007. The total number of patients who require admission due to both somatic and psychiatric diseases was investigated with their demographic and clinical characteristics.
    Results: The total number of patients admitted to psychiatric beds in general hospitals for the above-mentioned reason was 326, while the number of patients who could not be admitted to them despite the same reason was 88. The rate of surgical diseases in the latter group was higher than that in the former group. In the latter group, diseases requiring orthopedic surgery (22%) and abdominal surgery (22%) were the most frequent, followed by gastrointestinal and hepatic diseases (8%), and gynecological diseases (7%). Patients who had attempted suicide were included more in the latter group than in the former group. Even in the former group, general hospitals could not respond to 34% of requests for emergency admission.
    Conclusion: Psychiatric beds in general hospitals do not necessarily function for medical comorbidities in psychiatric patients, especially in severe and emergency cases. Not only the quantity but also the quality of psychiatric wards in general hospitals should be reconsidered.

    DOI: 10.1111/j.1440-1819.2009.01978.x

    Web of Science

    PubMed

    researchmap

  • Misdiagnosed delirium in patient referrals to a university-based hospital psychiatry department Reviewed

    Susan E. Swigart, Yasuhiro Kishi, Steven Thurber, Roger G. Kathol, William H. Meller

    PSYCHOSOMATICS   49 ( 2 )   104 - 108   2008.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:AMER PSYCHIATRIC PUBLISHING, INC  

    The authors examined the factors associated with referral errors in which the presence of delirium was ostensibly not recognized by medical staff personnel. Medical records of 541 University hospital patients consecutively referred for psychiatric consultation were scrutinized for extant delirium. The data indicated that a greater likelihood of a missed diagnosis was associated with younger age; referrals outside of family practice service; orientation as to person, place, and time; and a history of bipolar affective disorder or psychosis. The ramifications of failure to diagnose existing delirium include increased morbidity and mortality, longer length of hospital stay, and increased healthcare costs.

    DOI: 10.1176/appi.psy.49.2.104

    Web of Science

    PubMed

    researchmap

  • A comparison of psychiatric consultation-liaison services between hospitals in the United States and Japan Reviewed

    Yasuhiro Kishi, William H. Meller, Masashi Kato, Steven Thurber, Susan E. Swigart, Toru Okuyama, Katsunaka Mikami, Roger G. Kathol, Takashi Hosaka, Takayuki Aoki

    PSYCHOSOMATICS   48 ( 6 )   517 - 522   2007.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:AMER PSYCHIATRIC PUBLISHING, INC  

    The authors investigated psychiatric consultation in two hospitals, one in the United States, the other in Japan. They examined similarities and differences, and drew inferences on possible cross-cultural values and/or temporary cultural conditions. As compared with the Japanese consultation patients, the Americans had more mood disorders, including anxiety and chemical-dependency problems, in respective diagnostic classifications. Patients in the United States also showed more acute as well as more serious chronic conditions. These differences may relate to disorder base-rates in the respective countries. In general, psychosocial problems emerged as ascendant in Japan, as compared with chemical-dependency difficulties among American patients. The results are discussed in terms of current conditions in Japan that affect the mental health professions, together with attempts by Japanese clinicians to protect collective mores by ascribing causation for disorders to the individual, rather than the societal conditions often invoked in the United States.

    DOI: 10.1176/appi.psy.48.6.517

    Web of Science

    PubMed

    researchmap

  • Delirium: Patient characteristics that predict a missed diagnosis at psychiatric consultation Reviewed

    Yasuhiro Kishi, Masashi Kato, Toru Okuyama, Takashi Hosaka, Katsunaka Mikami, William Meller, Steven Thurber, Roger Kathol

    GENERAL HOSPITAL PSYCHIATRY   29 ( 5 )   442 - 445   2007.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER SCIENCE INC  

    Objective: This study evaluates patient characteristics that might predict a missed diagnosis of delirium prior to being seen by a psychiatric consultant.
    Method: Study participants were assessed using quantitative standardized scales of cognitive function, delirium and physical impairment.
    Results: Referring service personnel missed the diagnosis of delirium in 46% of psychiatric consultations. Two factors were associated with their failure to identify delirium accurately: use of a past psychiatric diagnosis to explain delirium symptoms and the presence of pain. Symptoms of delirium and quantitative scale scores did not distinguish between patients with whom diagnosis had been missed and those with accurate diagnoses.
    Conclusion: The consulting physicians of patients with delirium often incorrectly turn to past psychiatric diagnoses and/or are distracted by the presence of pain and, thus, fail to accurately diagnose delirium. (C) 2007 Elsevier Inc. All rights reserved.

    DOI: 10.1016/j.genhosppsych.2007.05.006

    Web of Science

    PubMed

    researchmap

  • Calculating treatment costs in an MBHO - In reply Reviewed

    Samuel H. Zuvekas, Agnes Rupp, Grayson Norquist

    PSYCHIATRIC SERVICES   58 ( 3 )   413 - 414   2007.3

     More details

    Language:English   Publisher:AMER PSYCHIATRIC PUBLISHING, INC  

    DOI: 10.1176/ps.2007.58.3.413

    Web of Science

    PubMed

    researchmap

  • Paroxetine-induced bruxism effectively treated with tandospirone Reviewed

    Yasuhiro Kishi

    JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES   19 ( 1 )   90 - 91   2007.2

     More details

    Language:English   Publisher:AMER PSYCHIATRIC PUBLISHING, INC  

    DOI: 10.1176/jnp.2007.19.1.90

    Web of Science

    PubMed

    researchmap

  • What should non-US behavioral health systems learn from the USA? US behavior health services trends in the 1980s and 1990s Reviewed

    Y Kishi, RG Kathol, DD McAlpine, WH Meller, SW Richards

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   60 ( 3 )   261 - 270   2006.6

     More details

    Language:English   Publisher:BLACKWELL PUBLISHING  

    Several countries, such as the USA, inadvertently created a different behavioral health payment system from the rest of medicine through the introduction of diagnostic-related group exemptions for psychiatric care. This led to isolation in the administration and delivery of care for patients with mental health and substance abuse disorders from other medical services with significant, yet unintended, consequences. To insure an efficient and effective health-care system, it is necessary to recognize the problems introduced by segregating behavioral health from the rest of medical care. In this review, the authors assess trends in behavioral health services during the last two decades in the USA, a period in which independently managed behavioral health care has dominated administrative practices. During this time, behavioral health has been an easy target for aggressive cost cutting measures. There have been no clinically significant improvements in the number of adults receiving minimally adequate treatment or in the percentage of the population with behavior health problems receiving psychiatric care with the possible exception of depression. While decreased spending for behavioral health services has been well documented during this period, these savings are offset by costs shifted to greater medical service use with a net increase in the total cost of health care. Targeting behavioral health for reduction in health-care spending through independent management, starting with diagnostic procedure code or diagnostic-related group exemption may not be the wisest approach in addressing the increasing fiscal burden that medical care is placing on the national economy.

    DOI: 10.1111/j.1440-1819.2006.01500.x

    Web of Science

    PubMed

    researchmap

  • General medical and pharmacy claims expenditures in users of behavioral health services Reviewed

    RG Kathol, D McAlpine, Y Kishi, R Spies, W Meller, T Bernhardt, S Eisenberg, K Folkert, W Gold

    JOURNAL OF GENERAL INTERNAL MEDICINE   20 ( 2 )   160 - 167   2005.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:SPRINGER  

    OBJECTIVE: To quantify the magnitude of general medical and/or pharmacy claims expenditures for individuals who use behavioral health services and to assess future claims when behavioral service use persists.
    DESIGN: Retrospective cost trends and 24-month cohort analyses.
    SETTING: A Midwest health plan.
    PARTICIPANTS: Over 250,000 health plan enrollees during 2000 and 2001.
    MEASUREMENTS: Claims expenditures for behavioral health services, general medical services, and prescription medications.
    MAIN RESULTS: Just over one tenth of enrollees (10.7%) in 2001 had at least 1 behavioral health claim and accounted for 21.4% of total general medical, behavioral health, and pharmacy claims expenditures. Costs for enrollees who used behavioral health services were double that for enrollees who did not use such services. Almost 80% of health care costs were for general medical services and medications, two thirds of which were not psychotropics. Total claims expenditures in enrollees with claims for both substance use and mental disorders in 2000 were 4 times that of those with general medical and/or pharmacy claims only. These expenditures returned to within 15% of nonbehavioral health service user levels in 2001 when clinical need for behavioral health services was no longer required but increased by another 37% between 2000 and 2001 when both chemical dependence and mental health service needs persisted.
    CONCLUSIONS: The majority of total claims expenditures in patients who utilize behavioral health services are for medical, not behavioral, health benefits. Continued service use is associated with persistently elevated total general medical and pharmacy care costs. These findings call for studies that better delineate: 1) the interaction of general medical, pharmacy, and behavioral health service use and 2) clinical and/or administrative approaches that reverse the high use of general medical resources in behavioral health patients.

    DOI: 10.1111/j.1525-1497.2005.40099.x

    Web of Science

    PubMed

    researchmap

  • Are the patients with post-transplant psychiatric consultation different from other medical-surgical consultation inpatients? Reviewed

    Y Kishi, WH Meller, SE Swigart, RG Kathol

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   59 ( 1 )   19 - 24   2005.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:BLACKWELL PUBLISHING ASIA  

    The present study examines the characteristics of post-transplant patients compared with non-transplant patients seen by consultation psychiatrists. Medical records of 541 consecutive psychiatric consultation patients at a university teaching hospital in 2001 were reviewed. Of the 541 patients who were evaluated, 67 were post-transplant patients. Post-transplant psychiatric consultation is different in some aspects from other psychiatric consultation. Post-transplant patients suffer complicated medical, psychiatric, and social burdens.

    DOI: 10.1111/j.1440-1819.2005.01326.x

    Web of Science

    PubMed

    researchmap

  • Factors affecting the relationship between the timing of psychiatric consultation and general hospital length of stay Reviewed

    Y Kishi, WH Meller, RG Kathol, SE Swigart

    PSYCHOSOMATICS   45 ( 6 )   470 - 476   2004.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:AMER PSYCHIATRIC PUBLISHING, INC  

    The purpose of this study was to examine the factors affecting the timing of psychiatric consultations and length of stay in the current managed care era. It also assessed the relationships between the timing of consultations and demographic/clinical characteristics. Medical records of 541 consecutive psychiatric consultation patients at a university teaching hospital in 2001 were reviewed for demographic characteristics, lengths of stay, number of days from admission to consultation, specialty services requesting consultations, reasons for the referral given by the referring physicians, and all five axes of DSM-IV Earlier consultations independently predicted shorter lengths of stay. Delayed consultations were seen more often in women; surgical patients; those seen with a request to assess depression; and those seen with a diagnosis of adjustment disorder delirium, or no psychiatric disorder Delay in psychiatric consultations continues to be associated with longer lengths of stay in the current managed care environment. It is now possible that early detection strategies for high-risk patients with behavioral health problems in the medical setting, such as use of the INTERMED, may lead to reduction in delayed psychiatric consultations and thus shorter lengths of stay.

    DOI: 10.1176/appi.psy.45.6.470

    Web of Science

    PubMed

    researchmap

  • Schizophrenia and narcolepsy: A review with a case report Reviewed

    Y Kishi, S Konishi, S Koizumi, Y Kudo, H Kurosawa, RG Kathol

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   58 ( 2 )   117 - 124   2004.4

     More details

    Language:English   Publisher:BLACKWELL PUBLISHING ASIA  

    Several reports emphasize the importance of differentiating between psychosis in schizophrenia and the psychotic form of narcolepsy. The failure to identify narcolepsy leads to the labeling of patients as refractory to standard treatments for schizophrenia and retards consideration of intervention for narcolepsy in which psychosis can improve with psychostimulant treatment. Psychosis in patients with narcolepsy can occur in three ways: (i) as the psychotic form of narcolepsy with hypnagogic and hypnopompic hallucinations; (ii) as a result of psychostimulant use in a patient with narcolepsy; and (iii) as the concurrent psychosis of schizophrenia in a patient with narcolepsy. The present case report describes a difficult-to-treat patient who likely had concurrent schizophrenia and narcolepsy. It then summarizes the literature related to the treatment of the three types of patients with psychosis associated with narcolepsy.

    Web of Science

    PubMed

    researchmap

  • [Post-operative psychiatric problems]. Reviewed

    Kishi Y

    Ryoikibetsu shokogun shirizu   ( 40 )   374 - 377   2003

     More details

  • Current status of general hospital psychiatry in Japan. Reviewed

    Kishi Y, Hosaka T, Kurosawa H

    Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica   105 ( 3 )   296 - 306   2003

     More details

  • Assessment of Patients Who Attempt Suicide. Reviewed

    Kishi Y, Kathol RG

    Primary care companion to the Journal of clinical psychiatry   4 ( 4 )   132 - 136   2002.8

     More details

  • Suicidal ideation among patients during the rehabilitation period after life-threatening physical illness Reviewed

    Y Kishi, RG Robinson, JT Kosier

    JOURNAL OF NERVOUS AND MENTAL DISEASE   189 ( 9 )   623 - 628   2001.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:LIPPINCOTT WILLIAMS & WILKINS  

    A total of 496 patients were examined for suicidal ideation during the acute hospital period and at 3, 6, 12, and 24 months' follow-up after suffering either stroke, traumatic brain injury, myocardial infarction, or spinal cord injury. A total of 7.3% of patients had suicidal ideation during the in-hospital evaluation (acute-onset suicidal ideation), and 11.3% developed it during the chronic 3 to 24 month rehabilitation period (delayed-onset suicidal ideation). Compared with delayed-onset suicidal patients, acute-onset suicidal patients had more predisposing risk factors (i.e., personal psychiatric history and alcohol abuse/dependence) and less social support (i.e., lower frequency of being married). Both acute and delayed-onset suicidal ideation, however, were strongly associated with the existence of major depression and impaired social functioning. These findings suggest that the detection and appropriate treatment of depressive disorders and social isolation may be the most important factor in preventing suicide both during the acute and chronic period following life-threatening physical illnesses.

    Web of Science

    PubMed

    researchmap

  • Suicidal ideation among patients with acute life-threatening physical illness - Patients with stroke, traumatic brain injury, myocardial infarction, and spinal cord injury Reviewed

    Y Kishi, RG Robinson, JT Kosier

    PSYCHOSOMATICS   42 ( 5 )   382 - 390   2001.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:AMER PSYCHIATRIC PRESS, INC  

    Suicide is one of the leading causes of death in the community. The risk of suicide is greater among patients with physical illnesses than among the general population. This study was undertaken to evaluate the clinical characteristics and correlates of suicidal ideation in patients with acute life-threatening physical illnesses and to assess the duration of suicidal ideation. The study included a consecutive series of patients admitted with stroke, traumatic brain injury myocardial infarction, or spinal cord injury (n = 496). Study participants were administered a semistructured psychiatric interview as well as a series of standardized quantitative scales of mood, cognitive function, physical impairment, social ties, and social functioning. Follow-up evaluations of up to 24 months were also carried out. This study found that 36 (7.3%) patients with acute medical illness had clinically, significant suicidal ideation. The suicidal ideation occurred mostly among patients with major depression and sometimes in those with minor depression. About 25% of patients with major depression and acute physical illnesses developed suicidal ideation. After the improvement of depressive disorders, suicidal ideations were ameliorated. These findings suggest that the detection and treatment of depressive disorders is the most important factor in preventing suicide among this patient population.

    DOI: 10.1176/appi.psy.42.5.382

    Web of Science

    PubMed

    researchmap

  • Integrating medical and psychiatric treatment in an inpatient medical setting - The type IV program Reviewed

    Y Kishi, RG Kathol

    PSYCHOSOMATICS   40 ( 4 )   345 - 355   1999.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:AMER PSYCHIATRIC PRESS, INC  

    This study compares the treatment of patients with comorbid medical and psychiatric illness admitted to a high-acuity (Type IV) integrated medicine and psychiatry inpatient program with patients having psychiatric symptoms on general internal medicine wards (IMWs). More patients in the Type IV program had agitation, suicidal ideation, or psychosis as psychiatric admission behaviors when compared to IMW patients. Medical symptom improvement was comparable in the two settings, whereas, psychiatric symptoms improved pd more in the Type IV Program than on the IMWs despite more significant illness and comparable lengths stay Integrated care on the Type IV unit allowed shorter total lengths of stay for medical patients with serious psychiatric illness than would have occurred had the traditional sequential approach to care been used The integrated Type IV medicine and psychiatry treatment program represents an efficient and effective process improvement in the way that medical patients with comorbid medical and psychiatric illness can be treated.

    DOI: 10.1016/S0033-3182(99)71230-2

    Web of Science

    PubMed

    researchmap

  • A preliminary study of staff perception of psychiatric services in general hospitals Reviewed

    H Ito, Y Kishi, H Kurosawa

    GENERAL HOSPITAL PSYCHIATRY   21 ( 1 )   57 - 61   1999.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER SCIENCE INC  

    There has been increasing recognition of the importance of integrating physical and psychiatric cave under growing economic pressure. We conducted a survey of staff perception on psychiatric services in four general hospitals. The purpose of this study was to see differences among the staff in their recognition and expectation of the role of the psychiatric department and the need for psychiatric and other staff to work more closely together. Although 81% of psychiatrists recognized their role in acute psychiatry, only 42.6% thought that acute psychiatry was the most important role of psychiatry. Mooed disorders were recognized as a psychiatric category in 95.2% of psychiatrists and 54.8% of nonpsychiatrist physicians. Overall satisfaction with psychiatric services in psychiatric and other staff were 54.0% and 68.2%, respectively. Although 85.7% of psychiatrists answered that they supported staff in other departments that have psychiatric or psychological problems, only 53.5% of those staff in other departments were satisfied with their support. Staff in other departments expected psychiatric staff to establish consultation hotlines and to visit other departments regularly. Our results suggest that there are discrepancies between psychiatric and other staff in their perception of psychiatric services, and it is our belief that those gaps must be bridged for better collaboration in general hospitals. (C) 1999 Elsevier Science Inc.

    Web of Science

    PubMed

    researchmap

  • The high acuity (type IV) integrated medicine and psychiatry treatment program: can Japan adopt this model of care? Reviewed

    Y Kishi, RG Kathol

    CUTTING EDGE MEDICINE AND LIAISON PSYCHIATRY   1174   23 - 31   1999

     More details

    Language:English   Publishing type:Research paper (international conference proceedings)   Publisher:ELSEVIER SCIENCE BV  

    The Japanese National Health and Welfare Task Force Panel for the Role of General Hospital Psychiatry reported that a high priority in the general hospital setting is to establish a system of integrated medical and psychiatric treatment programs. Although there are some integrated medical and psychiatric treatment programs in Japan, the concept of high acuity type IV programs has not been tried. To facilitate the establishment of the high quality integrated medical and psychiatric treatment programs in Japan, it would be helpful for Japanese psychiatrists and their primary care colleagues to analyze a model case of the type IV program in the USA.
    To establish the need and the benefit from establishing type IV treatment units, it is necessary to compare demographic, clinical and administrative characteristics and outcomes of patients with combined medical and psychiatric illness treated in a type IV program to patients treated on general medicine wards. The integrated type IV program represents an efficient and effective process improvement in the way that medical patients with combined medical and psychiatric illness can be treated. Involvement of both internal medicine and psychiatry facilitates a high acuity environment that increases the value of patient care. By adding the capabilities inherent in the type IV program, patients can be expected to have comparable improvement in medical illness and greater improvement of psychiatric illness than that provided on internal medicine wards yet to have similar lengths of stay even when more severe psychiatric illness is present. Such treatment reduces the cost of care for these complicated patients since concurrent rather than consecutive care can be provided.

    Web of Science

    researchmap

  • Is propranolol effective in primary polydipsia? Reviewed

    Y Kishi, H Kurosawa, S Endo

    INTERNATIONAL JOURNAL OF PSYCHIATRY IN MEDICINE   28 ( 3 )   315 - 325   1998

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:BAYWOOD PUBL CO INC  

    Objective: psychiatric patients presenting with polydipsia are often difficult to treat with standard psychiatric interventions. Pharmacological intervention was attempted in these patients based on the hypothesis that angiotensin II, a potent dipsinogen, may be involved in the drinking behavior of patients with polydipsia. Beta-blockers inhibit renin release land thus indirectly angiotensin II) by blocking beta receptors in the kidney. Methods: Three patients were identified as excessive water drinkers during their hospital admissions. All three patients were eunatremic but polydipsic at the time of study. Two of the three had histories of hyponatremia and required emergency medical treatment on more than one occasion. No patients had been controlled by strict fluid restriction. Trials of propranolol were initiated to control their water drinking. Results: After starting propranolol, two patients responded quickly. In one patient, fluid intake decreased from 2650 +/- 647 to 1577 +/- 361, p &lt; .001. In the other, fluid intake decreased from over 7000 mi before starting propranolol to around 3000 mi. The mean noon body weight of the third patient, in whom it was not possible to document fluid intake or urine volume before and after administering beta-blocker, was 72.6 +/- 2.6 Kg and 66.0 +/- 1.0 Kg, respectively (p &lt; .0001). Conclusions: These results suggest that propranolol may be useful for the treatment of polydipsia in patients with schizophrenia. Its efficacy could be related to inhibition of the renin-angiotensin system. Additional research using the controlled pharmacotherapeutic trials is required to confirm these findings.

    DOI: 10.2190/QPWL-14H7-HPGG-A29D

    Web of Science

    PubMed

    researchmap

  • Access to the emergency psychiatry system in Japan Reviewed

    Y Kishi, H Kurosawa, Y Iwasaki, R Hirayama, S Endo

    GENERAL HOSPITAL PSYCHIATRY   19 ( 2 )   130 - 137   1997.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER SCIENCE INC  

    Although the need for an emergency psychiatry system is increasing in Japan because of a shift to providing psychiatric care from hospitalization to community-based services, little attention is being given to what the general population expects from the health care system. To ascertain the expectations of the general population about how emergency psychiatric cases should be handled, the authors distributed a questionnaire to 1000 people containing 12 characteristic psychiatric emergency cases. The results showed that most expected psychiatric care to be rendered in a general hospital. This was different from the opinion held by most mental health professionals who felt that mental health hospitals should be the core hospitals of emergency psychiatry. Although there was a higher expectation for police officers or paramedics to provide emergent psychiatric care, the general population expected less from public health centers which now provide mental health service in the community. To connect emergency psychiatry with the community the general hospital must play a larger role in the system through training programs for general hospital psychiatrists as well as nonpsychiatrist professionals, paramedics, and police officers. (C) 1997 Elsevier Science, Inc.

    Web of Science

    PubMed

    researchmap

  • The validity of observed depression as a criteria for mood disorders in patients with acute stroke Reviewed

    Y Kishi, RG Robinson, JT Kosier

    JOURNAL OF AFFECTIVE DISORDERS   40 ( 1-2 )   53 - 60   1996.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER SCIENCE BV  

    The validity of observed depression as a criteria for major or minor depression was assessed among 301 patients with acute stroke. Patients who acknowledged a depressed mood or loss of interest (standard depression) were compared to patients who denied depression but were 'observed' to be depressed (non-standard depression) for the clinical correlates of depression. Although standard and non-standard major depressions had some clinical correlates such as increased frequency of female gender and prior psychiatric history, standard major depression patients had a significantly higher frequency of left hemisphere lesions than the non-standard major depression patients. These results support the validity of 'observed' depression as a criteria for major depression but also suggest the possibility that failure to report depressed mood may identify a condition with a different etiology than depression that is recognized and acknowledged. Observed depression, however, was not validated among patients with minor depression since there were no clinical or phenomenological differences from non-depression.

    Web of Science

    PubMed

    researchmap

  • Suicidal plans in patients with acute stroke Reviewed

    Y Kishi, JT Kosier, RG Robinson

    JOURNAL OF NERVOUS AND MENTAL DISEASE   184 ( 5 )   274 - 280   1996.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILLIAMS & WILKINS  

    The clinical correlates of suicidal thoughts were examined among a group of 301 patients with acute stroke. A total of 20 patients (6.6%) had suicidal thoughts. Previous history of stroke was associated with suicidal thoughts. Suicidal thoughts, however, were not related to severity of physical impairment. Most patients with suicidal thoughts met criteria for major depression. Other risk factors included younger age, poor social support, sensory deficit, and impaired cognitive function. Patients with suicidal plans had depression characterized by social withdrawal and brooding and self blame. Early identification of risk factors including the existence of depression may lead to effective therapeutic intervention.

    Web of Science

    PubMed

    researchmap

  • Suicidal plans following spinal cord injury: a six month study. Reviewed

    Kishi Y, Robinson RG

    The Journal of neuropsychiatry and clinical neurosciences   8 ( 4 )   442 - 445   1996

  • Suicidal plans in patients with stroke: Comparison between acute-onset and delayed-onset suicidal plans Reviewed

    Yasuhiro Kishi, Robert G. Robinson, James T. Kosier

    International Psychogeriatrics   8 ( 4 )   623 - 634   1996

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Three hundred one patients were examined for suicidal plans during the acute hospital period following stroke and at 3, 6, 12, and 24 months' follow-up. It was found that 6.6% of patients developed suicidal plans during the initial in-hospital evaluation (acute-onset suicidal plans) and 11.3% of patients developed suicidal plans at 3, 6, 12, or 24 months' follow-up (delayed-onset suicidal plans). The development of both acute and delayed-onset suicidal plans was strongly related to the existence of depressive disorders, especially major depression, and to a prior history of stroke. Acute-onset suicidal plans were also related to premorbid alcohol abuse. Acute-onset suicidal patients had more anterior lesion location and delayed-onset suicidal patients had more posterior stroke lesions. Delayed-onset suicidal plans were not related to alcohol abuse but tended to be associated with greater physical impairment and poorer social support during the acute poststroke period. These data suggest that the etiology of these two types of suicidal plans may be different with acute onset related to biological mechanisms and delayed onset related to psychological mechanisms.

    DOI: 10.1017/S1041610296002931

    Scopus

    PubMed

    researchmap

  • DELIRIUM IN CRITICAL CARE UNIT PATIENTS ADMITTED THROUGH AN EMERGENCY ROOM Reviewed

    Y KISHI, Y IWASAKI, K TAKEZAWA, H KUROSAWA, S ENDO

    GENERAL HOSPITAL PSYCHIATRY   17 ( 5 )   371 - 379   1995.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER SCIENCE PUBL CO INC  

    Two hundred thirty-eight patients admitted consecutively to a critical cave unit through an emergency room were assessed prospectively for the presence of delirium. Thirty-eight patients (16%) developed delirium. Delirium occurred with equal frequency in all disease categories. The presence of abnormal head imaging which required medical intervention did not predict the development of delirium. The median delay between admission and the development of delirious was 4 days, however, one-fourth of the patients were delirious on the day Of admission. The patients with abnormal head imaging who required medical intervention had a higher frequency of onset of delirium on the first day compared with patients without. The delirium lasted a median of 5 days and resolved within a week in over 70% of patients. These results confirm that delirium is frequently present in patients who require acute critical care after emergency room evaluation. In this population, serious medical disease is a better predictor of the development of delirium than the presence of abnormal brain imaging which required medical intervention. Although delirious patients have longer lengths of stay, the presence of delirium does not predict higher mortality, as has been reported in other populations. This could be because delirious patients admitted to the critical care unit through the emergency room have fewer premorbid medical problems predisposing them to poor outcome.

    Web of Science

    PubMed

    researchmap

  • COMPARISON BETWEEN ACUTE AND DELAYED-ONSET MAJOR DEPRESSION AFTER SPINAL-CORD INJURY Reviewed

    Y KISHI, RG ROBINSON, AW FORRESTER

    JOURNAL OF NERVOUS AND MENTAL DISEASE   183 ( 5 )   286 - 292   1995.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILLIAMS & WILKINS  

    Sixty patients with spinal cord injury were examined to assess major depression during the in-hospital period and at 3- and 6-month follow-up. Thirteen patients had depression during the initial in-hospital evaluation (acute onset depression) and eight had depression first diagnosed at either 3- or 6-month follow-up (delayed onset depression). Acute onset depression was related to the severity of impairment and premorbid history of psychiatric disorder, suggesting a psychological reaction to impairment or premorbid vulnerability as a possible mechanism for developing depression. Delayed onset depression was not related to severity of physical impairment but was associated with more rostral spinal injury, suggesting the possibility that neurophysiological response to injury more proximal to the brain may play a role in delayed onset depression. These data also suggest that the etiology and pathophysiology of these two types of depression may be different.

    Web of Science

    PubMed

    researchmap

  • Prospective longitudinal study of depression following spinal cord injury. Reviewed

    Kishi Y, Robinson RG, Forrester AW

    The Journal of neuropsychiatry and clinical neurosciences   6 ( 3 )   237 - 244   1994

  • THE PRACTICE OF CONSULTATION-LIAISON PSYCHIATRY IN JAPAN Reviewed

    H KUROSAWA, Y IWASAKI, N WATANABE, K NAKAMURA, Y KISHI, R HUSE

    GENERAL HOSPITAL PSYCHIATRY   15 ( 3 )   160 - 165   1993.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER SCIENCE INC  

    Consultation-liaison (C-L) psychiatry has been developing for the past 10 years as a new clinical service field in Japan. Although this kind of service had been practiced previously, it was not recognized as an independent clinical field. Still in the developing phase, clinical research in C-L psychiatry has been reported, although its quality has been variable. The authors describe the development and a typology of C-L psychiatry (seven types) in Japan. This article reports time spent on C-L psychiatry activity in a general hospital. Although C-L psychiatry requires much time and labor, hardly any of the C-L psychiatry services are reimbursed in the Japanese insurance system. The authors propose a ''new department'' as one option to continue providing C-L psychiatry service to general hospital patients and for further development of C-L psychiatry in Japan.

    Web of Science

    PubMed

    researchmap

▼display all

Misc.

▼display all

Research Projects

  • 高齢者のせん妄とてんかんとの関連性の解明とそれに基づく薬物療法的介入の開発

    Grant number:23K07045  2023.4 - 2026.3

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    八田 耕太郎, 杉田 学, 中村 裕之, 大山 覚照, 谷口 豪, 岸 泰宏, 竹内 崇, 臼井 千恵, 宮島 美穂

      More details

    Grant amount:\4810000 ( Direct Cost: \3700000 、 Indirect Cost:\1110000 )

    researchmap

  • メラトニン・オレキシン神経伝達を視点にした時間薬理学的なせん妄予防と発症予測研究

    Grant number:20K07927  2020.4 - 2023.3

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    八田 耕太郎, 一宮 洋介, 内村 直尚, 杉田 学, 中村 裕之, 東 晋二, 宮川 晃一, 岸 泰宏, 竹内 崇, 臼井 千恵

      More details

    Grant amount:\4420000 ( Direct Cost: \3400000 、 Indirect Cost:\1020000 )

    せん妄は、高齢化に伴いさらなる増加が見込まれ、生命予後、転倒、認知症発症に関わる医学全般の課題であるが、未だ適応薬剤がない。その中で研究代表者はせん妄に必発の睡眠覚醒サイクル障害に着目し、メラトニン受容体作動薬ラメルテオンやオレキシン受容体拮抗薬スボレキサントのせん妄予防効果をランダム化比較試験(RCT)で実証した。さらに、観察研究ではラメルテオンを就寝前より夕刻に投与する方が予防効果が高いことを見出した。本研究では、この結果をRCTで実証することによって、加齢に伴うメラトニン分泌量減少の補完のみならずメラトニン分泌リズムのずれの補完がせん妄予防に重要という時間薬理学的な仮説を検証する。
    今年度は、そのRCTを実施するために他施設共同研究を組織した。当初9病院の予定であったが、1つの病院が都合により不参加となったため8病院の研究組織となった。全体の研究計画を研究代表者の所属する順天堂大学医学部附属練馬病院倫理委員会で審査の上承認を得、年度末までに日本医大武蔵小杉病院、広島市民病院、東京医科歯科大学病院、東京医大茨城医療センター、福山市民病院、順天堂浦安病院の各倫理委員会から承認が得られた。残りの順天堂東京江東高齢者医療センターも次年度早々に審査が行われる状況となった。同時に、ランダム割付するための封筒法の準備、評価表の準備を完了した。特に、RICHARDS CAMPBELL SLEEP QUESTIONNAIRE(RCSQ)は原版および日本語訳版それぞれに版権があるため、各著作権者に連絡をとり使用許諾を得た。臨床研究保険への加入も完了した。このように次年度初日からRCTを開始できる体制を整えた。

    researchmap

  • Comprehensive research for prevention, treatment, and evaluation of delirium with respect to melatonin and orexin neurotransmission

    Grant number:17K10342  2017.4 - 2020.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    Hatta Kotaro

      More details

    Grant amount:\3510000 ( Direct Cost: \2700000 、 Indirect Cost:\810000 )

    The aim of this study was to examine the effectiveness of ramelteon (RAM) and suvorexant (SVR) on delirium prevention in real-world practice. We examined whether RAM and/or SVR would affect delirium prevention among both patients at risk for but without delirium (patients-at-risk), and those with delirium (patients-with-delirium) on the night before a consultation. Patients who were age 65 years or older and hospitalized because of acute diseases or elective surgery, had risk factors for delirium, and had insomnia or delirium on the night before the consultation were prescribed RAM and/or SVR. Among 526 patients-at-risk, those taking RAM and/or SVR developed delirium significantly less frequently than those who did not. Similar results were found among 422 patients-with-delirium. RAM and SVR appears to be effective for delirium prevention in real-world practice.

    researchmap

  • Prediction, prevention, and treatment of delirium from the perspective of neuroinflammation

    Grant number:26461773  2014.4 - 2017.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    Hatta Kotaro

      More details

    Grant amount:\4940000 ( Direct Cost: \3800000 、 Indirect Cost:\1140000 )

    We examined whether suvorexant, a potent and selective orexin receptor antagonist, is effective for the prevention of delirium.Method: We conducted a multi-center, rater-blinded, randomized placebo-controlled clinical trial in intensive care units and regular acute wards between April 2015 and March 2016. Eligible patients were 65-89 years old and newly admitted due to emergency. Seventy-two patients were randomly assigned to receive suvorexant (15 mg/day; 36 patients) and placebo (36 patients) every night for three days. The primary outcome measure was incidence of delirium as determined by the DSM-5. Trained psychiatrists assessed for delirium. We found that development of delirium occurred significantly less often among patients taking suvorexant than those taking placebo (0% [n/N=0/36] vs. 17% [6/36], P=.025). Suvorexant administered nightly to elderly patients admitted for acute care may provide protection against delirium.

    researchmap

  • A study on treatment, prevention, and medical safty of delirium

    Grant number:23591728  2011.4 - 2015.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    HATTA Kotaro, KISHI Yasuhiro, ODAWARA Toshinari, TAKEUCHI Takashi, SUGITA Manabu, USUI Chie, KAMIJO Yoshito, MACHIDA Yutaka, NAKAMURA Hiroyuki

      More details

    Grant amount:\5070000 ( Direct Cost: \3900000 、 Indirect Cost:\1170000 )

    First, we have demonstrated preventive effects of ramelteon, a melatonin agonist, on delirium through a randomized placebo-controlled trial. This finding supports a possible pathogenic role of melatonin neurotransmission in delirium. This accomplishment may provide a paradigm shift from treatment to prevention in clinical practice of delirium. Second, we have demonstrated the predictive value of a change in natural killer cell activity for delirium. The importance of delirium prediction may increase as we have developed an effective prevention method. Third, we have demonstrated that in the general hospital setting under management including fine dosage adjustment in individual patients and the early detection of side-effects, antipsychotics have a low risk in the treatment of patients with delirium, and have high efficacy.
    These findings such as prevention, prediction, and treatment will provide clinical guidelines for delirium.

    researchmap