Updated on 2024/01/25

写真a

 
Atsumi Kenichiro
 
Affiliation
Tamanagayama Hospital, Department of Pulmonary Medicine, Infectious Disease and Oncology, Assistant Professor
Title
Assistant Professor
External link

Degree

  • 医学博士 ( 日本医科大学 )

Research Areas

  • Life Science / Respiratory medicine

Research History

  • 日本医科大学多摩永山病院   呼吸器・腫瘍内科   助教

    2020.4

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  • 日本医科大学大学院医学研究科   呼吸器内科学分野   助教

    2013.1 - 2020.3

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  • 日本医科大学千葉北総病院   呼吸器内科

    2010.10 - 2013.12

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  • 海老名総合病院   呼吸器内科

    2007.9 - 2010.9

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  • 慈山会医学研究所付属坪井病院   呼吸器内科

    2005.7 - 2007.8

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  • 日本医科大学付属病院   呼吸器内科

    2003.5 - 2005.6

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Professional Memberships

  • 日本睡眠学会専門医

    2022.8

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  • 日本呼吸器内視鏡学会専門医

    2019.1

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  • 日本呼吸器学会専門医

    2017.12

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  • 日本内科学会総合内科専門医

    2016.12

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  • 日本内科学会認定内科医

    2009.9

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Papers

  • Thyroid transcription factor-1 (TTF-1) expression and the efficacy of combination therapy with immune checkpoint inhibitors and cytotoxic chemotherapy in non-squamous non-small cell lung cancer. International journal

    Hirokazu Iso, Kakeru Hisakane, Erika Mikami, Takahiro Suzuki, Satoru Matsuki, Kenichiro Atsumi, Kohji Nagata, Masahiro Seike, Takashi Hirose

    Translational lung cancer research   12 ( 9 )   1850 - 1861   2023.9

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    BACKGROUND: Thyroid transcription factor-1 (TTF-1) is expressed in approximately 70% of lung adenocarcinomas and is one of the most reliable makers to distinguish primary lung adenocarcinoma from metastatic disease. TTF-1-negative status is a poor prognostic factor, and TTF-1-negative lung adenocarcinoma is associated with poor efficacy of immune checkpoint inhibitor (ICI) monotherapy. However, the relationship between TTF-1 expression and the efficacy of ICI plus chemotherapy is still unclear. METHODS: We performed a retrospective analysis of 129 consecutive patients with advanced non-squamous non-small cell lung cancer (NS-NSCLC) treated with ICI monotherapy or ICI plus chemotherapy between January 2016 and December 2021. The expression of programmed death ligand-1 (PD-L1) and TTF-1 was also determined in cases for which no previous data were available. We then evaluated the association between TTF-1 expression status and treatment efficacy. RESULTS: Of the 129 cases, 33 were TTF-1-negative and 96 were positive. In the ICI monotherapy group (N=70), progression-free survival (PFS) was not significantly different between TTF-1-positive and negative patients (median 3.6 vs. 3.8 months, P=0.27); however, in patients with wild-type epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK), a trend for worse PFS was observed in TTF-1-negative cases compared with those that were TTF-1-positive (median 3.8 vs. 4.5 months, P=0.088). Moreover, long-term efficacy of ICI monotherapy (>2 years) was not observed in the TTF-1-negative group. TTF-1-negative patients tended to have worse overall survival (OS) than TTF-1-positive patients (median 15.6 vs. 19.5 months, P=0.13). In the ICI plus chemotherapy group (N=59), TTF-1-negative patients tended to have better PFS and similar OS compared with TTF-1-positive patients (median 9.9 vs. 9.6 months, P=0.14; median 32.3 vs. 18.9 months, P=0.78). Long-term efficacy was generally observed in TTF-1-negative patients treated with atezolizumab plus bevacizumab plus carboplatin plus paclitaxel (ABCP) (median PFS 22.5 months, median OS not reached). CONCLUSIONS: ICI monotherapy is generally less efficacious in TTF-1-negative NS-NSCLC patients, and clinicians should consider ICI plus chemotherapy in these cases. Our study suggests that ABCP is an optimal regimen for TTF-1-negative NS-NSCLC.

    DOI: 10.21037/tlcr-23-331

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  • irAE腸炎再燃との鑑別を要したPPI誘発性collagenous colitisの一例

    白倉 ゆかり, 久金 翔, 鄒 奮飛, 門間 直大, 二島 駿一, 渥美 健一郎, 土生 亜美, 田中 周, 永田 耕治, 清家 正博, 廣瀬 敬

    日本結核・非結核性抗酸菌症学会関東支部学会・日本呼吸器学会関東地方会合同学会プログラム・抄録集   184回・256回   20 - 20   2023.9

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    Language:Japanese   Publisher:日本結核・非結核性抗酸菌症学会関東支部学会・日本呼吸器学会関東地方会  

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  • Cohort study to evaluate prognostic factors in idiopathic pulmonary fibrosis patients introduced to oxygen therapy

    Kensuke Kataoka, Keishi Oda, Hajime Takizawa, Takashi Ogura, Atsushi Miyamoto, Yoshikazu Inoue, Shinobu Akagawa, Seishu Hashimoto, Tomoo Kishaba, Koji Sakamoto, Naoki Hamada, Kazuyoshi Kuwano, Masayuki Nakayama, Masahito Ebina, Noriyuki Enomoto, Yasunari Miyazaki, Kenichiro Atsumi, Shinyu Izumi, Yoshinori Tanino, Hiroshi Ishii, Hiroshi Ohnishi, Takafumi Suda, Yasuhiro Kondoh

    Scientific Reports   13 ( 1 )   2023.8

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    Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    Abstract

    While high-level evidence is lacking, numerous retrospective studies have depicted the value of supplemental oxygen in idiopathic pulmonary fibrosis (IPF) and other interstitial lung diseases, and its use should be encouraged where necessary. The clinical course and survival of patients with IPF who have been introduced to oxygen therapy is still not fully understood. The objective of this study was to clarify overall survival, factors associated with prognosis, and causes of death in IPF patients after the start of oxygen therapy. This is a prospective cohort multicenter study, enrolling patients with IPF who started oxygen therapy at 19 hospitals with expertise in interstitial lung disease. Baseline clinical data at the start of oxygen therapy and 3-year follow-up data including death and cause of death were assessed. Factors associated with prognosis were analyzed using univariable and multivariable analyses. One hundred forty-seven eligible patients, of whom 86 (59%) were prescribed ambulatory oxygen therapy and 61 (41%) were prescribed long-term oxygen therapy, were recruited. Of them, 111 died (76%) during a median follow-up of 479 days. The median survival from the start of oxygen therapy was 537 ± 74 days. In the univariable analysis, low body mass index (BMI), low forced vital capacity (FVC), low diffusion capacity (DLCO), resting hypoxemia, short 6 min-walk distance, and high COPD assessment test (CAT) score were significantly associated with poor prognosis. Multivariable analysis revealed low BMI, low FVC, low DLCO, low minimum SpO2 on 6MWT, and high CAT score were independent factors for poor prognosis. The overall survival of IPF patients after starting oxygen therapy is about 1.5 years. In addition to pulmonary function tests, 6MWT and patient reported outcomes can be used to predict prognosis more accurately.

    Clinical Trial Registration: UMIN000009322.

    DOI: 10.1038/s41598-023-40508-8

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    Other Link: https://www.nature.com/articles/s41598-023-40508-8

  • Minimal effective dose of maintenance steroid therapy for relapse of cryptogenic organizing pneumonia. International journal

    Kenichiro Atsumi, Kakeru Hisakane, Erika Mikami, Takahiro Suzuki, Satoru Matsuki, Masahiro Seike, Takashi Hirose

    Respiratory medicine   107390 - 107390   2023.8

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    BACKGROUND: Long-term maintenance steroid therapy (MST) is frequently required for repeated relapses of cryptogenic organizing pneumonia (COP); however, the optimal minimal dose has not been clarified. Therefore, this study evaluated the minimal MST dose required to prevent repeated relapses and identify relapse predictors. METHODS: We retrospectively reviewed the medical records of patients with steroid-treated COP and compared background factors between the non-relapse and relapse groups. We also reviewed the treatment course in the relapse group and determined the minimal effective steroid dose based on the MST dose at relapse events and the current relapse prevention dose. RESULTS: In total, 48 patients were identified, including 27 (56%) in the non-relapse group and 21 (44%) in the relapse group. Receiver operating characteristic curve analysis identified prednisolone at 5 mg/day as the optimal cut-off value in the relapse group. Relapse-free time in patients with relapsed COP was significantly longer in the MST dose ≥5 mg/day group than in the <5 mg/day group (log-rank P = 0.003; hazard ratio, 0.19; 95% confidence interval [CI], 0.04-0.60). Multivariate logistic regression analysis demonstrated that a high eosinophil percentage and CD4/CD8 ratio in bronchoalveolar lavage fluid (BALF) were predictors of relapse (odds ratio [OR], 1.12; 95% CI, 1.02-1.23; P = 0.008 and OR, 3.87; 95% CI, 1.29-11.6; P = 0.008, respectively). CONCLUSIONS: Our results indicate that 5 mg/day of prednisolone may be the minimal effective dose for preventing repeated relapses, and a high BALF eosinophil percentage and CD4/CD8 ratio are independent predictors of relapse.

    DOI: 10.1016/j.rmed.2023.107390

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  • 肺原発紡錘細胞癌に対してCBDCA+PTX+Nivolumab+Ipilimumabを投与し奏効した1例

    鈴木 貴大, 三上 恵莉花, 久金 翔, 渥美 健一郎, 廣瀬 敬, 永田 耕治, 清家 正博

    肺癌   63 ( 4 )   328 - 328   2023.8

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    Language:Japanese   Publisher:(NPO)日本肺癌学会  

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  • Platinum-combination chemotherapy with or without immune-checkpoint inhibitor in patients with postoperative recurrent non-small cell lung cancer previously treated with adjuvant platinum-doublet chemotherapy: A multicenter retrospective study. International journal

    Kakeru Hisakane, Takehiro Tozuka, Satoshi Takahashi, Namiko Taniuchi, Nobuhiko Nishijima, Kenichiro Atsumi, Tetsuya Okano, Masahiro Seike, Takashi Hirose

    Thoracic cancer   14 ( 21 )   2069 - 2076   2023.7

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    BACKGROUND: Rechallenge with platinum-combination chemotherapy in patients with advanced non-small cell lung cancer (NSCLC) after disease progression on platinum-combination chemotherapy occasionally leads to a favorable response. The efficacy and safety of platinum-combination chemotherapy with or without immune-checkpoint inhibitor (ICI) for patients with recurrent NSCLC after surgery followed by adjuvant platinum-doublet chemotherapy remains uncertain. METHODS: Patients who relapsed after surgery plus adjuvant platinum-doublet chemotherapy and received platinum-combination chemotherapy with or without ICI between April 2011 and March 2021 at four Nippon Medical School hospitals were retrospectively analyzed. RESULTS: Among 177 patients who received adjuvant platinum-doublet chemotherapy after surgery, a total of 30 patients who received platinum-combination rechemotherapy with or without ICI after relapse were included in this study. Seven patients received ICI-combined chemotherapy. The median disease-free survival (DFS) after surgery was 13.6 months. The objective response rate and disease-control rate were 46.7% and 80.0%, respectively. The median progression-free survival and overall survival were 10.2 and 37.5 months, respectively. Patients with longer DFS (≥12 months) had a better prognosis than others. The most common grade ≥3 toxicity associated with this treatment was neutropenia (33%). Grade ≥3 immune-related adverse events were pneumonitis (14%) and colitis (14%). Treatment-related deaths did not occur in this study. CONCLUSION: Platinum-combination chemotherapy with or without ICI for patients with postoperative recurrent NSCLC who previously received adjuvant platinum-doublet chemotherapy was effective and safe. In particular, this therapy may be promising for patients with longer DFS.

    DOI: 10.1111/1759-7714.14992

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  • Development of eosinophilic pneumonia from eosinophilic bronchiolitis without asthma: A case report

    Erika Mikami, Kenichiro Atsumi, Hirokazu Iso, Takahiro Suzuki, Satoru Matsuki, Kakeru Hisakane, Koji Nagata, Masahiro Seike, Takashi Hirose

    Respiratory Medicine Case Reports   45   2023.7

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    Eosinophilic bronchiolitis is a disease concept reported in Japan in 2001, that presents with bronchiolitis accompanied by eosinophilia in the blood and lungs. In 2013, hypereosinophilic obliterative bronchiolitis, as a group of disease presenting with eosinophilic bronchiolitis, was proposed in France. The relationship between eosinophilic bronchiolitis and other eosinophil-related diseases has not been clarified. Herein, we report the case of a 56-year-old female patient with eosinophilic bronchiolitis without asthma, which developed into eosinophilic pneumonia. Treatment with oral prednisone improved the respiratory function. According to the clinicopathological findings in this case, eosinophilic bronchiolitis may be a different disease from asthma.

    DOI: 10.1016/j.rmcr.2023.101901

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  • A remarkable response to combination chemotherapy with nivolumab and ipilimumab in a patient with primary pulmonary choriocarcinoma: a case report

    Hirokazu Iso, Kakeru Hisakane, Naoki Terashi, Erika Mikami, Satoru Matsuki, Takumi Sonokawa, Kenichiro Atsumi, Naoyuki Yoshino, Kohji Nagata, Masahiro Seike, Takashi Hirose

    TRANSLATIONAL CANCER RESEARCH   2023.7

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:AME PUBLISHING COMPANY  

    Background: Primary pulmonary choriocarcinoma (PPC) is a rare malignancy, and only 41 PPC cases have been reported in males up to 2021. Due to its rarity, no standardized treatments for PPC have been established. Cytotoxic chemotherapy has limited efficacy, and the prognosis of advanced PPC is notably poor. Immune checkpoint inhibitors (ICIs) are expected to provide long-term survival for PPC patients, but only a few cases have been reported. The optimal treatment for PPC has not been determined.Case Description: Here, we report a 72-year-old male with post-surgery relapsed PPC, presenting with multiple pulmonary nodules and an intracardiac mass. The OncomineTM Dx target test showed no mutation of cancer-relevant genes, and programmed death-ligand 1 (PD-L1) expression was negative (0%) in the 22C3 assay. He received a combination of carboplatin, paclitaxel, nivolumab, and ipilimumab which is widely used as a first-line treatment for advanced non-small-cell lung cancer (NSCLC). Two months after treatment began, computed tomography (CT) showed multiple lung nodules and an intracardiac mass reduction, which has been sustained for 12 months. Grade 3 febrile neutropenia and grade 2 rash were observed, however, these adverse events were manageable. Conclusions: This is the first case of postoperative relapse PPC that has been successfully treated with the combination of chemotherapy, nivolumab, and ipilimumab. This therapy may be a promising option for advanced PPC.

    DOI: 10.21037/tcr-23-221

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  • 急性細気管支炎・リステリア菌血症を契機に発見されたHTLV-1関連気管支肺疾患の1例

    三上 恵莉花, 渥美 健一郎, 鈴木 貴大, 松本 覚, 久金 翔, 山中 聡, 尾崎 勝俊, 永田 耕治, 清家 正博, 廣瀬 敬

    気管支学   45 ( 3 )   241 - 241   2023.5

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  • 特発性器質化肺炎再発の背景因子と再発後のステロイド至適維持量

    渥美 健一郎, 久金 翔, 三上 恵莉花, 磯 博和, 松木 覚, 清家 正博, 廣瀬 敬

    日本呼吸器学会誌   12 ( 増刊 )   320 - 320   2023.3

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  • 胸水セルブロックで診断に至ったIgM型ALアミロイドーシスの一例

    鈴木 貴大, 久金 翔, 宮寺 恵希, 三上 恵莉花, 松木 覚, 渥美 健一郎, 栗林 泰子, 尾崎 勝俊, 永田 耕治, 清家 正博, 廣瀬 敬

    日本結核・非結核性抗酸菌症学会関東支部学会・日本呼吸器学会関東地方会合同学会プログラム・抄録集   183回・253回   24 - 24   2023.2

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  • 術後プラチナ併用化学療法後の再発非小細胞肺癌に対するプラチナ併用化学療法±ICIの有効性と安全性の検討

    久金 翔, 戸塚 猛大, 高橋 聡, 谷内 七三子, 西島 伸彦, 渥美 健一郎, 小齊平 聖治, 神尾 孝一郎, 岡野 哲也, 弦間 昭彦, 清家 正博, 廣瀬 敬

    肺癌   62 ( 6 )   593 - 593   2022.11

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  • 術後プラチナ併用化学療法後の再発非小細胞肺癌に対するプラチナ併用化学療法±ICIの有効性と安全性の検討

    久金 翔, 戸塚 猛大, 高橋 聡, 谷内 七三子, 西島 伸彦, 渥美 健一郎, 小齊平 聖治, 神尾 孝一郎, 岡野 哲也, 弦間 昭彦, 清家 正博, 廣瀬 敬

    肺癌   62 ( 6 )   593 - 593   2022.11

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  • A Case of Pseudo-progression-like Pleurisy After Combined Treatment with Nivolumab and Ipilimumab for Lung Adenocarcinoma

    Terashima Yuto, Hisakane Kakeru, Atsumi Kenichiro, Terashi Naoki, Suzuki Ayana, Nagata Koji, Seike Masahiro, Gemma Akihiko, Hirose Takashi

    Haigan   62 ( 5 )   400 - 405   2022.10

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    Language:Japanese   Publisher:The Japan Lung Cancer Society  

    Background. The frequency of pseudo-progression caused by immune-checkpoint inhibitors in non-small cell lung cancer (NSCLC) is approximately 5%. Thus far, most reports of pseudo-progression in NSCLC have been due to immune-checkpoint inhibitor monotherapy. We report a case of pseudo-progression-like pleurisy after combined treatment with nivolumab and ipilimumab for lung adenocarcinoma. Case. A 70-year-old man with adenocarcinoma (pT3N0M1a, stage IVA) with pleural dissemination received combination therapy consisting of carboplatin, pemetrexed, nivolumab, and ipilimumab as first-line treatment. After treatment, he had fever, dyspnea, elevated CRP, and developed pleural effusion on the affected side. Thoracic drainage was subsequently performed. Abundant T lymphocytes with predominant CD4-positive cells infiltration were observed in pleural fluid cell-block specimens. Afterwards, his symptoms improved. No further accumulation of pleural effusion was observed, even though he continued receiving chemotherapy. Hence, he was diagnosed with pseudo-progression rather than an immune-related adverse event (irAE). Conclusion. This is the first report of pseudo-progression-like pleurisy in a lung cancer patient after combined nivolumab and ipilimumab treatment. It is important to distinguish pseudo-progression from irAE-induced pleurisy.

    DOI: 10.2482/haigan.62.400

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  • カルボプラチン+パクリタキセル+ニボルマブ+イピリムマブ併用療法が奏効した肺原発絨毛癌の1例

    磯 博和, 久金 翔, 三上 恵莉花, 松木 覚, 渥美 健一郎, 廣瀬 敬, 永田 耕治, 吉野 直之, 清家 正博, 弦間 昭彦

    肺癌   62 ( 5 )   460 - 460   2022.10

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  • Black pleural effusion caused by a pancreaticopleural fistula associated with autoimmune pancreatitis: A case report. International journal

    Keiki Miyadera, Kakeru Hisakane, Yuki Kato, Kenichiro Atsumi, Hiroki Ono, Shu Tanaka, Kaoru Kubota, Masahiro Seike, Akihiko Gemma, Takashi Hirose

    Medicine   101 ( 36 )   e30322   2022.9

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    RATIONALE: Black pleural effusion is a rare medical condition and a diagnostic marker. Pancreaticopleural fistula is one of the causes of black pleural effusion. Thus far, black pleural effusions caused by pancreaticopleural fistulae have mostly been reported in patients with alcohol-induced chronic pancreatitis. In this report, we present a case of black pleural effusion caused by a pancreaticopleural fistula associated with autoimmune pancreatitis. PATIENT CONCERNS AND DIAGNOSIS: A 59-year-old female without a history of alcohol drinking presented to our hospital with a chief complaint of dyspnea, as well as chest and back discomfort. She had left pleural effusion, and thoracentesis showed black pleural effusion. Computed tomography revealed the presence of encapsulated fluid from the pancreatic tail to the left pleural cavity, which was diagnosed as a pancreaticopleural fistula. It also showed diffuse pancreatic swelling. Serum testing showed a high IgG4 level (363 mg/dL). These findings led to the diagnosis of autoimmune pancreatitis. INTERVENTIONS AND OUTCOME: The patient underwent endoscopic pancreatic sphincterotomy and pancreatic duct stent placement and received treatment with steroids. After treatment, there was no further accumulation of pleural effusion observed. CONCLUSION: This is the first report of black pleural effusion due to a pancreaticopleural fistula associated with autoimmune pancreatitis. The characteristic appearance of black pleural effusion may assist diagnosis. We report this case to emphasize that autoimmune pancreatitis can be a cause of black pleural effusion.

    DOI: 10.1097/MD.0000000000030322

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  • びまん性汎細気管支炎との鑑別を要した好酸球性細気管支炎の1例

    三上 恵莉花, 渥美 健一郎, 磯 博和, 松木 覚, 久金 翔, 永田 耕治, 清家 正博, 廣瀬 敬

    日本結核・非結核性抗酸菌症学会関東支部学会・日本呼吸器学会関東地方会合同学会プログラム・抄録集   182回・251回   36 - 36   2022.9

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  • A Case of Fulminant Type 1 Diabetes Mellitus After the Administration of Durvalumab for Small-cell Lung Cancer

    Terashi Naoki, Hisakane Kakeru, Miyadera Keiki, Kato Yuki, Terashima Yuto, Suzuki Ayana, Atsumi Kenichiro, Seike Masahiro, Gemma Akihiko, Hirose Takashi

    Haigan   62 ( 4 )   323 - 328   2022.8

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    Language:Japanese   Publisher:The Japan Lung Cancer Society  

    Background. Fulminant type 1 diabetes mellitus caused by immune checkpoint inhibitors is a rare adverse event. In lung cancer, several cases have been reported in non-small-cell lung cancer. We herein report a patient with small-cell lung cancer who developed fulminant type 1 diabetes mellitus after administration of durvalumab. Case. A 71-year-old man with extensive-stage small-cell lung cancer (cT4N3M1b, stage IVA) with no history of diabetes mellitus received combination therapy of carboplatin, etoposide, and durvalumab on May 20XX. He became aware of anorexia and fatigue on day 27. He was diagnosed with fulminant type 1 diabetes mellitus caused by durvalumab with hyperglycemia of 761 mg/dl, positive urine ketones, and urinary C-peptide of 3.9 μg/day on the second course of treatment (day 30). After his blood glucose level had been stabilized with insulin therapy, an additional three cycles of chemotherapy with carboplatin and etoposide were administered. A significant response was achieved, and the patient survived without disease progression. Conclusion. Fulminant type 1 diabetes mellitus caused by durvalumab for small-cell lung cancer is a rare but urgent immune-related adverse event that requires attention.

    DOI: 10.2482/haigan.62.323

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  • デュルバルマブ投与後に激症1型糖尿病を発症した小細胞肺癌の1例

    寺師 直樹, 久金 翔, 宮寺 恵希, 寺嶋 勇人, 鈴木 彩奈, 渥美 健一郎, 廣瀬 敬, 清家 正博, 弦間 昭彦

    肺癌   62 ( 2 )   139 - 139   2022.4

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  • COVID-19感染の回復期の白血球像の分析

    渥美 健一郎, 久金 翔, 鈴木 彩奈, 清家 正博, 弦間 昭彦, 廣瀬 敬

    日本呼吸器学会誌   11 ( 増刊 )   234 - 234   2022.4

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  • 肺扁平上皮癌に対するPembrolizumab投与中に発症した耳介軟骨炎の1例

    寺嶋 勇人, 渥美 健一郎, 寺師 直樹, 鈴木 彩奈, 久金 翔, 永田 耕治, 細矢 慶, 清家 正博, 弦間 昭彦, 廣瀬 敬

    日本内科学会関東地方会   676回   70 - 70   2022.3

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  • 免疫チェックポイント阻害剤投与後に発症した、免疫関連有害事象による副腎機能低下症の3例

    宮下 稜太, 中山 幸治, 齊藤 翔, 渥美 健一郎, 廣瀬 敬, 久保田 馨, 清家 正博, 弦間 昭彦

    肺癌   61 ( 7 )   992 - 992   2021.12

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  • EGFR遺伝子変異陽性肺癌における繰り返し再生検の有効性とオシメルチニブの効果

    廣瀬 敬, 渥美 健一郎, 加藤 祐樹, 宮寺 恵希, 久金 翔, 久保田 馨, 清家 正博, 弦間 昭彦

    肺癌   61 ( 6 )   602 - 602   2021.10

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  • EGFR遺伝子変異陽性肺癌における繰り返し再生検の有効性とオシメルチニブの効果

    廣瀬 敬, 渥美 健一郎, 加藤 祐樹, 宮寺 恵希, 久金 翔, 久保田 馨, 清家 正博, 弦間 昭彦

    肺癌   61 ( 6 )   602 - 602   2021.10

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  • 黒色胸水を契機に診断された膵胸腔瘻の1例

    宮寺 恵希, 久金 翔, 加藤 祐樹, 渥美 健一郎, 大野 弘貴, 田中 周, 久保田 馨, 清家 正博, 弦間 昭彦, 廣瀬 敬

    日本結核・非結核性抗酸菌症学会関東支部学会・日本呼吸器学会関東地方会合同学会プログラム・抄録集   180回・246回   18 - 18   2021.9

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  • 黒色胸水を契機に診断された膵胸腔瘻の1例

    宮寺 恵希, 久金 翔, 加藤 祐樹, 渥美 健一郎, 大野 弘貴, 田中 周, 久保田 馨, 清家 正博, 弦間 昭彦, 廣瀬 敬

    日本結核・非結核性抗酸菌症学会関東支部学会・日本呼吸器学会関東地方会合同学会プログラム・抄録集   180回・246回   18 - 18   2021.9

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  • 【内科疾患の診断基準・病型分類・重症度】(第1章)呼吸器 診断メモ サルコイドーシス

    渥美 健一郎, 吾妻 安良太

    内科   127 ( 4 )   546 - 546   2021.4

  • 自家骨髄細胞による肺線維症モデルマウスの病態改善効果に関する研究

    神尾 孝一郎, 吾妻 安良太, 松田 久仁子, 猪俣 稔, 久世 眞之, 臼杵 二郎, 田中 徹, 柏田 建, 佐藤 純平, 西島 伸彦, 渥美 健一郎, 齋藤 好信, 清家 正博, 弦間 昭彦

    日本呼吸器学会誌   10 ( 増刊 )   179 - 179   2021.4

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  • 間質性肺炎に伴う肺高血圧症に対する%FVC/%DLcoの有用性の検討

    渥美 健一郎, 田中 徹, 柏田 建, 田中 庸介, 齋藤 好信, 藤田 和恵, 廣瀬 敬, 清家 正博, 吾妻 安良太, 木村 弘, 弦間 昭彦

    日本呼吸器学会誌   10 ( 増刊 )   303 - 303   2021.4

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  • 自家骨髄細胞による肺線維症モデルマウスの病態改善効果に関する研究

    神尾 孝一郎, 吾妻 安良太, 松田 久仁子, 猪俣 稔, 久世 眞之, 臼杵 二郎, 田中 徹, 柏田 建, 佐藤 純平, 西島 伸彦, 渥美 健一郎, 齋藤 好信, 清家 正博, 弦間 昭彦

    日本呼吸器学会誌   10 ( 増刊 )   179 - 179   2021.4

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  • 間質性肺炎に伴う肺高血圧症に対する%FVC/%DLcoの有用性の検討

    渥美 健一郎, 田中 徹, 柏田 建, 田中 庸介, 齋藤 好信, 藤田 和恵, 廣瀬 敬, 清家 正博, 吾妻 安良太, 木村 弘, 弦間 昭彦

    日本呼吸器学会誌   10 ( 増刊 )   303 - 303   2021.4

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  • Atezolizumab併用化学療法中にANCA関連血管炎を発症した一例

    齊藤 翔, 中山 幸治, 宮下 稜太, 渥美 健一郎, 中里 玲, 金子 朋広, 永田 耕治, 清水 章, 久保田 馨, 清家 正博, 弦間 昭彦, 廣瀬 敬

    日本結核・非結核性抗酸菌症学会関東支部学会・日本呼吸器学会関東地方会合同学会プログラム・抄録集   179回・243回   22 - 22   2021.2

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  • Rictor-targeting exosomal microRNA-16 ameliorates lung fibrosis by inhibiting the mTORC2-SPARC axis. International journal

    Inomata Minoru, Kamio Koichiro, Azuma Arata, Matsuda Kuniko, Usuki Jiro, Morinaga Akemi, Tanaka Toru, Kashiwada Takeru, Atsumi Kenichiro, Hayashi Hiroki, Fujita Kazue, Saito Yoshinobu, Kubota Kaoru, Seike Masahiro, Gemma Akihiko

    Experimental cell research   398 ( 2 )   112416 - 112416   2021.1

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    Idiopathic pulmonary fibrosis (IPF), a progressive disorder of unknown etiology, is characterized by pathological lung fibroblast activation and proliferation resulting in abnormal deposition of extracellular matrix proteins within the lung parenchyma. The pathophysiological roles of exosomal microRNAs in pulmonary fibrosis remain unclear; therefore, we aimed to identify and characterize fibrosis-responsive exosomal microRNAs. We used microRNA array analysis and profiled the expression of exosome-derived miRNA in sera of C57BL/6 mice exhibiting bleomycin-induced pulmonary fibrosis. The effect of microRNAs potentially involved in fibrosis was then evaluated in vivo and in vitro. The expression of exosomal microRNA-16 was increased by up to 8.0-fold on day 14 in bleomycin-treated mice, compared to vehicle-treated mice. MicroRNA-16 mimic administration on day 14 after bleomycin challenge ameliorated pulmonary fibrosis and suppressed lung and serum expression of secreted protein acidic and rich in cysteine (SPARC). Pretreatment of human lung fibroblasts with the microRNA-16 mimic decreased the expression of rapamycin-insensitive companion of mTOR (Rictor) and TGF-β1-induced expression

    DOI: 10.1016/j.yexcr.2020.112416

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  • A possible, non-invasive method of measuring dynamic lung compliance in patients with interstitial lung disease using photoplethysmography.

    Atsumi Kenichiro, Saito Yoshinobu, Tanaka Toru, Kashiwada Takeru, Hayashi Hiroki, Kamio Koichiro, Seike Masahiro, Osaki Rie, Sakai Kazuhiro, Kurosawa Shinya, Gemma Akihiko, Azuma Arata

    Journal of Nippon Medical School   88 ( 4 )   326 - 334   2020.9

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    Measuring lung compliance is useful for evaluating interstitial lung disease (ILD) progression because reduced lung compliance by fibrosis progression is the main primary cause of decreased vital capacity. However, because of the invasiveness of the method, requiring the insertion of a balloon into the esophagus, lung compliance is rarely measured. A recently developed, possible method estimates intrathoracic pressure using fingertip photoplethysmography. This method non-invasively measures the lung dynamic compliance (Cdyn) by simultaneously measuring tidal volume. We evaluated the efficacy of this method in assessing ILD.We conducted a single-center, observational cross-sectional study to evaluate the efficacy of this method in subjects with ILD as compared with that in healthy control subjects. The main outcome was the estimated Cdyn (eCdyn) determined using this method. We also evaluated potential confounding factors of eCdyn in the baseline characteristics.In the ILD group (n = 14) the median eCdyn was significantly lower than that in the control group (n = 49) (0.122 vs. 0.183; P = 0.011). In univariate regression analysis, eCdyn was significantly correlated with height, weig

    DOI: 10.1272/jnms.JNMS.2021_88-411

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  • 肺癌合併特発性肺線維症の急性増悪例における、分類改定案を用いた予後の検討

    柏田 建, 齋藤 好信, 渥美 健一郎, 大森 美和子, 二島 駿一, 田中 徹, 神尾 孝一郎, 田中 庸介, 木村 弘, 吾妻 安良太, 清家 正博, 弦間 昭彦

    日本呼吸器学会誌   9 ( 増刊 )   252 - 252   2020.8

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  • 肺線維症 新規治療に関する基礎研究 血清エクソソーム由来microRNAによる肺線維芽細胞から筋線維芽細胞への分化調節機構の検討

    久世 眞之, 神尾 孝一郎, 吾妻 安良太, 松田 久仁子, 猪俣 稔, 田中 徹, 柏田 建, 渥美 健一郎, 齋藤 好信, 出雲 雄大, 清家 正博, 弦間 昭彦

    日本呼吸器学会誌   9 ( 増刊 )   139 - 139   2020.8

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  • 特発性肺線維症 急性増悪の新知見 特発性肺線維症における抗線維化薬治療中に発症した間質性肺炎急性増悪の予後

    二島 駿一, 齋藤 好信, 湯浅 瑞希, 清水 理光, 田中 徹, 柏田 建, 渥美 健一郎, 神尾 孝一郎, 田中 庸介, 藤田 和恵, 木村 弘, 吾妻 安良太, 清家 正博, 弦間 昭彦

    日本呼吸器学会誌   9 ( 増刊 )   141 - 141   2020.8

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  • 光電式容積脈波センサによる間質性肺疾患の動肺コンプライアンス測定の有用性

    渥美 健一郎, 齋藤 好信, 湯浅 瑞希, 清水 理光, 二島 駿一, 田中 徹, 柏田 建, 田中 庸介, 藤田 和恵, 木村 弘, 清家 正博, 大崎 理江, 酒井 一泰, 黒澤 慎也, 弦間 昭彦, 吾妻 安良太

    日本呼吸器学会誌   9 ( 増刊 )   315 - 315   2020.8

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  • 気管支動脈蔓状血管腫に肺血栓塞栓症を合併した1例

    千田 絵里佳, 柏田 建, 湯浅 瑞希, 二島 駿一, 恩田 直美, 田中 徹, 渥美 健一郎, 峯岸 裕司, 田中 庸介, 齋藤 好信, 木村 弘, 清家 正博, 弦間 昭彦

    気管支学   42 ( 4 )   356 - 357   2020.7

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  • EGFR-TKIによる薬剤性肺障害に対して気管支鏡にて肺胞出血と診断した3症例

    千田 絵里佳, 清水 理光, 湯浅 瑞希, 二島 駿一, 恩田 直美, 田中 徹, 柏田 建, 中道 真仁, 菅野 哲平, 渥美 健一郎, 峯岸 裕司, 野呂 林太郎, 田中 庸介, 齋藤 好信, 木村 弘, 久保田 馨, 清家 正博, 弦間 昭彦

    気管支学   42 ( Suppl. )   S249 - S249   2020.6

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  • 気管支肺胞洗浄液を用いたPCR検査により診断に至ったインフルエンザ肺炎の4例

    芳賀 三四郎, 田中 徹, 湯浅 瑞希, 清水 理光, 二島 駿一, 柏田 建, 渥美 健一郎, 田中 庸介, 齋藤 好信, 藤田 和恵, 木村 弘, 久保田 馨, 清家 正博, 弦間 昭彦

    気管支学   42 ( Suppl. )   S278 - S278   2020.6

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  • 当院における肺非結核性抗酸菌症診断に対する気管支鏡検査の有用性に関する検討

    宮寺 恵希, 湯浅 瑞希, 清水 理光, 二島 駿一, 田中 徹, 柏田 建, 渥美 健一郎, 田中 庸介, 齋藤 好信, 藤田 和恵, 木村 弘, 久保田 馨, 清家 正博, 弦間 昭彦

    気管支学   42 ( Suppl. )   S218 - S218   2020.6

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  • EGFR-TKIによる薬剤性肺障害に対して気管支鏡にて肺胞出血と診断した3症例

    千田 絵里佳, 清水 理光, 湯浅 瑞希, 二島 駿一, 恩田 直美, 田中 徹, 柏田 建, 中道 真仁, 菅野 哲平, 渥美 健一郎, 峯岸 裕司, 野呂 林太郎, 田中 庸介, 齋藤 好信, 木村 弘, 久保田 馨, 清家 正博, 弦間 昭彦

    気管支学   42 ( Suppl. )   S249 - S249   2020.6

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  • HIV-PCPの治療中にCMV感染症を発症した一例

    松木 覚, 渥美 健一郎, 芳賀 三四郎, 田中 徹, 清水 理光, 湯浅 瑞希, 二島 駿一, 柏田 建, 田中 庸介, 藤田 和恵, 齋藤 好信, 木村 弘, 清家 正博, 弦間 昭彦

    日本結核・非結核性抗酸菌症学会関東支部学会・日本呼吸器学会関東地方会合同学会プログラム・抄録集   177回・238回   23 - 23   2020.2

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  • EBUS-GS-TBBの診断率に影響を与える因子

    戸塚 猛大, 清家 正博, 田中 徹, 菅野 哲平, 渥美 健一郎, 林 宏紀, 齋藤 好信, 久保田 馨, 弦間 昭彦

    気管支学   42 ( 1 )   14 - 20   2020.1

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    <p>背景.末梢肺病変に対するガイドシース併用気管支腔内超音波断層法(endobronchial ultrasonography with a guide sheath:EBUS-GS)を用いた肺生検(EBUS-GS-TBB)の有用性が示されているが,診断に影響を与える因子は明らかになっていない.目的.EBUS-GS-TBBの診断に影響を与える因子を明らかにすることを目的とした.方法.日本医科大学付属病院において2016年7月から2018年4月までにEBUS-GSを用いて肺生検が施行された118例の中で,最終的に確定診断が得られた101例を後方視的に検討した.EBUSのプローブの位置によって,エコー所見を'within','outside','broadly adjacent to','narrowly adjacent to'の4つに分類した.Adjacent toの中でプローブ周囲の180度以上360度未満の範囲に病変が描出されたものをbroadly adjacent toと新たに定義し,それ以外をnarrowly adjacent toと新たに定義した.結果.EBUS-GSによる確定診断率は78.2%であった.多変量解析にて,エコー所見がwithinまたはbroadly adjacent toの患者は診断率

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  • 気管支鏡にて診断した汎血球減少改善に伴い発症したメトトレキサート肺炎の1例

    芳賀 三四郎, 田中 徹, 湯浅 瑞希, 清水 理光, 二島 駿一, 柏田 建, 渥美 健一郎, 田中 庸介, 齋藤 好信, 寺崎 泰弘, 木村 弘, 久保田 馨, 清家 正博, 弦間 昭彦

    気管支学   42 ( 1 )   99 - 99   2020.1

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  • Severe Pneumonitis with Alveolar Hemorrhage Associated with Herbal Medicines: A Case Report. Reviewed

    Miwako Omori, Yoshinobu Saito, Yukiko Miura, Toru Tanaka, Takeru Kashiwada, Kenichiro Atsumi, Hiroki Hayashi, Yuji Minegishi, Kazue Fujita, Arata Azuma, Masahiro Seike, Akihiko Gemma

    Journal of Nippon Medical School = Nippon Ika Daigaku zasshi   86 ( 5 )   296 - 300   2019.12

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    We report a case of pneumonitis with alveolar hemorrhage induced by herbal medicines in a 73-year-old woman who was admitted to our hospital because of dyspnea and an abnormal shadow on a chest radiograph. She had received treatment with numerous drugs, including the herbal medicines Seisin-renshi-in, Chotosan, Rikkunshi-to, and Shakuyakukannzo-to. Chest radiography revealed diffuse ground-glass shadows in both lungs, and bronchoalveolar lavage fluid was progressively hemorrhagic. A culture of the fluid showed no evidence of microorganisms. Moreover, there were no findings suggestive of rheumatic disease or vasculitides. On the basis of this evidence, we suspected drug-induced diffuse alveolar hemorrhage. She discontinued all medicines and started treatment with corticosteroids. Her respiratory condition and chest radiographic findings improved. The timing of administration and rechallenge with other drugs suggested that the herbal medicines were the causative drugs. The primary concern was Seisin-renshi-in, because it contains Ougon (skullcap; a known cause of pneumonitis) and because a drug lymphocyte stimulation test was positive for Seisin-renshi-in. This is the first report indicating that Seisin-renshi-in may cause diffuse alveolar hemorrhage. Diffuse alveolar hemorrhage due to herbal medicines is a rare but emergent disorder. Therefore, treating physicians should be aware that it may be caused by herbal medicines, including Seisin-renshi-in.

    DOI: 10.1272/jnms.JNMS.2019_86-504

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  • Severe Pneumonitis with Alveolar Hemorrhage Associated with Herbal Medicines: A Case Report.

    Miwako Omori, Yoshinobu Saito, Yukiko Miura, Toru Tanaka, Takeru Kashiwada, Kenichiro Atsumi, Hiroki Hayashi, Yuji Minegishi, Kazue Fujita, Arata Azuma, Masahiro Seike, Akihiko Gemma

    Journal of Nippon Medical School = Nippon Ika Daigaku zasshi   86 ( 5 )   296 - 300   2019.12

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    We report a case of pneumonitis with alveolar hemorrhage induced by herbal medicines in a 73-year-old woman who was admitted to our hospital because of dyspnea and an abnormal shadow on a chest radiograph. She had received treatment with numerous drugs, including the herbal medicines Seisin-renshi-in, Chotosan, Rikkunshi-to, and Shakuyakukannzo-to. Chest radiography revealed diffuse ground-glass shadows in both lungs, and bronchoalveolar lavage fluid was progressively hemorrhagic. A culture of the fluid showed no evidence of microorganisms. Moreover, there were no findings suggestive of rheumatic disease or vasculitides. On the basis of this evidence, we suspected drug-induced diffuse alveolar hemorrhage. She discontinued all medicines and started treatment with corticosteroids. Her respiratory condition and chest radiographic findings improved. The timing of administration and rechallenge with other drugs suggested that the herbal medicines were the causative drugs. The primary concern was Seisin-renshi-in, because it contains Ougon (skullcap; a known cause of pneumonitis) and because a drug lymphocyte stimulation test was positive for Seisin-renshi-in. This is the first report indicating that Seisin-renshi-in may cause diffuse alveolar hemorrhage. Diffuse alveolar hemorrhage due to herbal medicines is a rare but emergent disorder. Therefore, treating physicians should be aware that it may be caused by herbal medicines, including Seisin-renshi-in.

    DOI: 10.1272/jnms.JNMS.2019_86-504

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  • Weekly paclitaxel in combination with carboplatin for advanced non-small-cell lung cancer complicated by idiopathic interstitial pneumonias: a single-arm phase II study. Reviewed

    Aya Fukuizumi, Yuji Minegishi, Miwako Omori, Kenichiro Atsumi, Natsuki Takano, Kakeru Hisakane, Satoshi Takahashi, Kenichi Kobayashi, Teppei Sugano, Susumu Takeuchi, Rintaro Noro, Masahiro Seike, Kaoru Kubota, Arata Azuma, Akihiko Gemma

    International journal of clinical oncology   24 ( 12 )   1543 - 1548   2019.12

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    BACKGROUND: Idiopathic interstitial pneumonias (IIPs) are associated with increased risk of lung cancer. In Japan, acute exaberation of IIPs induced by anticancer treatment is a critical issue. For this reason, there is limited available evidence regarding the optimal treatment approach for lung cancer patients complicated with IIPs. Our previous prospective pilot study demonstrated the safety and efficacy of weekly paclitaxel in combination with carboplatin for advanced non-small-cell lung cancer (NSCLC) with IIPs. The current study was conducted to confirm the results of the same combination therapy used in a larger patient population. METHODS: Chemotherapy-naïve patients with advanced stage or post-operative recurrent NSCLC patients complicated by IIPs were enrolled. Patients received paclitaxel (100 mg/m2) on days 1, 8, and 15, and carboplatin (AUC 5.0) once every 4 weeks. RESULTS: Thirty-three of 35 enrolled patients were evaluable for analysis and received a median of four treatment cycles (range 1-6). Four patients (12.1%; 95% confidence interval 3.4-28.2%) had acute exacerbation (AEx)-related IIPs to the study treatment. However, no fatalities due to AEx were observed. The overall response was 69.7%. The median progression-free survival, median survival time, and 1-year survival were 6.3 months, 19.8 months, and 55.4%, respectively. CONCLUSIONS: The efficacy of carboplatin plus weekly paclitaxel treatment for advanced NSCLC patients with IIPs was comparable to that of conventional chemotherapy in advanced NSCLC patients without IIPs. Moreover, the primary endpoint was set to the frequency of treatment-related acute exacerbation, and the primary endpoint was met. These results suggest that patients with advanced NSCLC complicated by IIPs may benefit from this combination chemotherapy.

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  • Exosome-derived microRNA-22 ameliorates pulmonary fibrosis by regulating fibroblast-to-myofibroblast differentiation both in vitro and in vivo.

    Kuse Naoyuki, Kamio Koichiro, Azuma Arata, Matsuda Kuniko, Inomata Minoru, Usuki Jiro, Morinaga Akemi, Tanaka Toru, Kashiwada Takeru, Atsumi Kenichiro, Hayashi Hiroki, Saito Yoshinobu, Seike Masahiro, Gemma Akihiko

    Journal of Nippon Medical School = Nippon Ika Daigaku zasshi   2019.11

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    BackgroundAlthough aberrant proliferation and activation of lung fibroblasts are implicated in the initiation and progression of idiopathic pulmonary fibrosis (IPF), the underlying mechanisms are not well characterized. Numerous microRNAs (miRNAs) have been implicated in this process; however, miRNAs derived from exosomes and their relevance to fibroblast-to-myofibroblast differentiation have not been fully elucidated. In this study, we aimed to identify exosome-derived miRNAs relevant to fibrosis development.MethodsWe profiled exosome-derived miRNAs expression in sera of C57BL/6 mice exhibiting bleomycin-induced pulmonary fibrosis by miRNA array analysis. After validating a selected miRNA by quantitative reverse-transcription polymerase chain reaction, its effect on fibroblast- to-myofibroblast differentiation was investigated using human lung fibroblasts. Furthermore, we determined the role of the selected miRNA in an in-vivo pulmonary fibrosis model.ResultsMiRNA array analysis revealed that miR-22 expression was increased by up to 2 fold on day 7 after bleomycin treatment compared with that in vehicle-treated mice. In vitro, miR-22 transfectionsuppressed TGF-β1-induced α-SMA e

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  • Exosome-derived microRNA-22 ameliorates pulmonary fibrosis by regulating fibroblast-to-myofibroblast differentiation both in vitro and in vivo. Reviewed

    Naoyuki Kuse, Koichiro Kamio, Arata Azuma, Kuniko Matsuda, Minoru Inomata, Jiro Usuki, Akemi Morinaga, Toru Tanaka, Takeru Kashiwada, Kenichiro Atsumi, Hiroki Hayashi, Yoshinobu Saito, Masahiro Seike, Akihiko Gemma

    Journal of Nippon Medical School = Nippon Ika Daigaku zasshi   87 ( 3 )   118 - 128   2019.11

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    BackgroundAlthough aberrant proliferation and activation of lung fibroblasts are implicated in the initiation and progression of idiopathic pulmonary fibrosis (IPF), the underlying mechanisms are not well characterized. Numerous microRNAs (miRNAs) have been implicated in this process; however, miRNAs derived from exosomes and their relevance to fibroblast-to-myofibroblast differentiation have not been fully elucidated. In this study, we aimed to identify exosome-derived miRNAs relevant to fibrosis development.MethodsWe profiled exosome-derived miRNAs expression in sera of C57BL/6 mice exhibiting bleomycin-induced pulmonary fibrosis by miRNA array analysis. After validating a selected miRNA by quantitative reverse-transcription polymerase chain reaction, its effect on fibroblast- to-myofibroblast differentiation was investigated using human lung fibroblasts. Furthermore, we determined the role of the selected miRNA in an in-vivo pulmonary fibrosis model.ResultsMiRNA array analysis revealed that miR-22 expression was increased by up to 2 fold on day 7 after bleomycin treatment compared with that in vehicle-treated mice. In vitro, miR-22 transfectionsuppressed TGF-β1-induced α-SMA expression. This was mediated via the inhibition of the ERK1/2 pathway. Baseline α-SMA expression was increased upon miR-22 inhibitor transfection. Furthermore, miR-22 negatively regulated connective tissue growth factor expression in the presence of TGF-β1. In vivo, administration of a miR-22 mimic on day 10 after bleomycin challenge ameliorated pulmonary fibrosis lesions accompanied by decreased α-SMA expression in the model mice.ConclusionsExosomal miR-22 modulates fibroblast-to-myofibroblast differentiation. The present study warrants further investigations to shed light on miR-22 as a novel therapeutic target for patients with IPF.

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  • Weekly paclitaxel in combination with carboplatin for advanced non-small-cell lung cancer complicated by idiopathic interstitial pneumonias: a single-arm phase II study.

    Fukuizumi Aya, Minegishi Yuji, Omori Miwako, Atsumi Kenichiro, Takano Natsuki, Hisakane Kakeru, Takahashi Satoshi, Kobayashi Kenichi, Sugano Teppei, Takeuchi Susumu, Noro Rintaro, Seike Masahiro, Kubota Kaoru, Azuma Arata, Gemma Akihiko

    International journal of clinical oncology   2019.7

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    Idiopathic interstitial pneumonias (IIPs) are associated with increased risk of lung cancer. In Japan, acute exaberation of IIPs induced by anticancer treatment is a critical issue. For this reason, there is limited available evidence regarding the optimal treatment approach for lung cancer patients complicated with IIPs. Our previous prospective pilot study demonstrated the safety and efficacy of weekly paclitaxel in combination with carboplatin for advanced non-small-cell lung cancer (NSCLC) with IIPs. The current study was conducted to confirm the results of the same combination therapy used in a larger patient population.Chemotherapy-naïve patients with advanced stage or post-operative recurrent NSCLC patients complicated by IIPs were enrolled. Patients received paclitaxel (100 mg/m) on days 1, 8, and 15, and carboplatin (AUC 5.0) once every 4 weeks.Thirty-three of 35 enrolled patients were evaluable for analysis and received a median of four treatment cycles (range 1-6). Four patients (12.1%; 95% confidence interval 3.4-28.2%) had acute exacerbation (AEx)-related IIPs to the study treatment. However, no fatalities due to AEx were observed. The overall response was 69.7%. Th

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  • EBUS-TBNA後に気管支内穿破,内腔にポリープ状の隆起性病変を来たした結核性リンパ節炎の1例 Reviewed

    久金 翔, 藤田 和恵, 菅野 哲平, 高野 夏希, 二島 駿一, 高橋 聡, 田中 徹, 柏田 建, 渥美 健一郎, 武内 進, 宮永 晃彦, 林 宏紀, 齋藤 好信, 久保田 馨, 木村 弘, 清家 正博, 弦間 昭彦

    気管支学   41 ( Suppl. )   S255 - S255   2019.6

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  • 当院における気管支サーモプラスティの使用経験

    北川 真吾, 林 宏紀, 高野 夏希, 二島 駿一, 久金 翔, 高橋 聡, 田中 徹, 柏田 建, 菅野 哲平, 渥美 健一郎, 藤田 和恵, 齋藤 好信, 木村 弘, 久保田 馨, 清家 正博, 弦間 昭彦

    気管支学   41 ( Suppl. )   S349 - S349   2019.6

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  • Organizing Pneumonia after Nivolumab Treatment in a Patient with Pathologically Proven Idiopathic Pulmonary Fibrosis. Reviewed

    Takeru Kashiwada, Yuji Minegishi, Yoshinobu Saito, Tomomi Kato, Kenichiro Atsumi, Masahiro Seike, Kaoru Kubota, Yasuhiro Terasaki, Akihiko Gemma

    Journal of Nippon Medical School = Nippon Ika Daigaku zasshi   86 ( 1 )   43 - 47   2019

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    Acute exacerbation of pre-existing interstitial lung disease (ILD) associated with systemic anticancer therapy is recognized as a life-threatening adverse event of lung cancer treatment. Programmed cell death 1 (PD-1) checkpoint inhibitors, such as nivolumab, often induce pneumonitis in patients with cancer; however, the tolerance and safety of nivolumab for advanced lung cancer with ILD are unclear. We report a 72-year-old patient with lung cancer with pathologically proven idiopathic pulmonary fibrosis who was treated with nivolumab. She demonstrated pneumonitis with an organized pneumonia (OP) pattern, but no acute exacerbation of ILD featuring a diffuse alveolar damage (DAD) pattern. She was successfully treated with corticosteroid therapy, and maintained good disease control after the discontinuation of nivolumab. She also showed pseudoprogression of the primary tumor, implying infiltration of T-cells into the lung. These findings suggest that T-cell activation by nivolumab treatment might not be directly associated with acute ILD exacerbation, and that treatable OP might be a major pulmonary complication of nivolumab in patients with pre-existing ILD, similar to patients without underlying ILD.

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  • Organizing Pneumonia after Nivolumab Treatment in a Patient with Pathologically Proven Idiopathic Pulmonary Fibrosis.

    Kashiwada Takeru, Minegishi Yuji, Saito Yoshinobu, Kato Tomomi, Atsumi Kenichiro, Seike Masahiro, Kubota Kaoru, Terasaki Yasuhiro, Gemma Akihiko

    Journal of Nippon Medical School = Nippon Ika Daigaku zasshi   86 ( 1 )   43 - 47   2019

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    Acute exacerbation of pre-existing interstitial lung disease (ILD) associated with systemic anticancer therapy is recognized as a life-threatening adverse event of lung cancer treatment. Programmed cell death 1 (PD-1) checkpoint inhibitors, such as nivolumab, often induce pneumonitis in patients with cancer; however, the tolerance and safety of nivolumab for advanced lung cancer with ILD are unclear. We report a 72-year-old patient with lung cancer with pathologically proven idiopathic pulmonary fibrosis who was treated with nivolumab. She demonstrated pneumonitis with an organized pneumonia (OP) pattern, but no acute exacerbation of ILD featuring a diffuse alveolar damage (DAD) pattern. She was successfully treated with corticosteroid therapy, and maintained good disease control after the discontinuation of nivolumab. She also showed pseudoprogression of the primary tumor, implying infiltration of T-cells into the lung. These findings suggest that T-cell activation by nivolumab treatment might not be directly associated with acute ILD exacerbation, and that treatable OP might be a major pulmonary complication of nivolumab in patients with pre-existing ILD, similar to patients with

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  • Resolution of bleomycin-induced murine pulmonary fibrosis via a splenic lymphocyte subpopulation. Reviewed International journal

    Koichiro Kamio, Arata Azuma, Kuniko Matsuda, Jiro Usuki, Minoru Inomata, Akemi Morinaga, Takeru Kashiwada, Nobuhiko Nishijima, Shioto Itakura, Nariaki Kokuho, Kenichiro Atsumi, Hiroki Hayashi, Tomoyoshi Yamaguchi, Kazue Fujita, Yoshinobu Saito, Shinji Abe, Kaoru Kubota, Akihiko Gemma

    Respiratory research   19 ( 1 )   71 - 71   2018.4

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    BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a progressive disease with high mortality, and the pathogenesis of the disease is still incompletely understood. Although lymphocytes, especially CD4+CD25+FoxP3+ regulatory T cells (Tregs), have been implicated in the development of IPF, contradictory results have been reported regarding the contribution of Tregs to fibrosis both in animals and humans. The aim of this study was to investigate whether a specific T cell subset has therapeutic potential in inhibiting bleomycin (BLM)-induced murine pulmonary fibrosis. METHODS: C57BL/6 mice received BLM (100 mg/kg body weight) with osmotic pumps (day 0), and pulmonary fibrosis was induced. Then, splenocytes or Tregs were adoptively transferred via the tail vein. The lungs were removed and subjected to histological and biochemical examinations to study the effects of these cells on pulmonary fibrosis, and blood samples were collected by cardiac punctures to measure relevant cytokines by enzyme-linked immunosorbent assay. Tregs isolated from an interleukin (IL)-10 knock-out mice were used to assess the effect of this mediator. To determine the roles of the spleen in this model, spleen vessels were carefully cauterized and the spleen was removed either on day 0 or 14 after BLM challenge. RESULTS: Splenocytes significantly ameliorated BLM-induced pulmonary fibrosis when they were administered on day 14. This effect was abrogated by depleting Tregs with an anti-CD25 monoclonal antibody. Adoptive transfer of Tregs on day 14 after a BLM challenge significantly attenuated pulmonary fibrosis, and this was accompanied by decreased production of fibroblast growth factor (FGF) 9-positive cells bearing the morphology of alveolar epithelial cells. In addition, BLM-induced plasma IL-10 expression reverted to basal levels after adoptive transfer of Tregs. Moreover, BLM-induced fibrocyte chemoattractant chemokine (CC motif) ligand-2 production was significantly ameliorated by Treg adoptive transfer in lung homogenates, accompanied by reduced accumulation of bone-marrow derived fibrocytes. Genetic ablation of IL-10 abrogated the ameliorating effect of Tregs on pulmonary fibrosis. Finally, splenectomy on day 0 after a BLM challenge significantly ameliorated lung fibrosis, whereas splenectomy on day 14 had no effect. CONCLUSIONS: These findings warrant further investigations to develop a cell-based therapy using Tregs for treating IPF.

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  • Resolution of bleomycin-induced murine pulmonary fibrosis via a splenic lymphocyte subpopulation. International journal

    Koichiro Kamio, Arata Azuma, Kuniko Matsuda, Jiro Usuki, Minoru Inomata, Akemi Morinaga, Takeru Kashiwada, Nobuhiko Nishijima, Shioto Itakura, Nariaki Kokuho, Kenichiro Atsumi, Hiroki Hayashi, Tomoyoshi Yamaguchi, Kazue Fujita, Yoshinobu Saito, Shinji Abe, Kaoru Kubota, Akihiko Gemma

    Respiratory research   19 ( 1 )   71 - 71   2018.4

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    BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a progressive disease with high mortality, and the pathogenesis of the disease is still incompletely understood. Although lymphocytes, especially CD4+CD25+FoxP3+ regulatory T cells (Tregs), have been implicated in the development of IPF, contradictory results have been reported regarding the contribution of Tregs to fibrosis both in animals and humans. The aim of this study was to investigate whether a specific T cell subset has therapeutic potential in inhibiting bleomycin (BLM)-induced murine pulmonary fibrosis. METHODS: C57BL/6 mice received BLM (100 mg/kg body weight) with osmotic pumps (day 0), and pulmonary fibrosis was induced. Then, splenocytes or Tregs were adoptively transferred via the tail vein. The lungs were removed and subjected to histological and biochemical examinations to study the effects of these cells on pulmonary fibrosis, and blood samples were collected by cardiac punctures to measure relevant cytokines by enzyme-linked immunosorbent assay. Tregs isolated from an interleukin (IL)-10 knock-out mice were used to assess the effect of this mediator. To determine the roles of the spleen in this model, spleen vessels were carefully cauterized and the spleen was removed either on day 0 or 14 after BLM challenge. RESULTS: Splenocytes significantly ameliorated BLM-induced pulmonary fibrosis when they were administered on day 14. This effect was abrogated by depleting Tregs with an anti-CD25 monoclonal antibody. Adoptive transfer of Tregs on day 14 after a BLM challenge significantly attenuated pulmonary fibrosis, and this was accompanied by decreased production of fibroblast growth factor (FGF) 9-positive cells bearing the morphology of alveolar epithelial cells. In addition, BLM-induced plasma IL-10 expression reverted to basal levels after adoptive transfer of Tregs. Moreover, BLM-induced fibrocyte chemoattractant chemokine (CC motif) ligand-2 production was significantly ameliorated by Treg adoptive transfer in lung homogenates, accompanied by reduced accumulation of bone-marrow derived fibrocytes. Genetic ablation of IL-10 abrogated the ameliorating effect of Tregs on pulmonary fibrosis. Finally, splenectomy on day 0 after a BLM challenge significantly ameliorated lung fibrosis, whereas splenectomy on day 14 had no effect. CONCLUSIONS: These findings warrant further investigations to develop a cell-based therapy using Tregs for treating IPF.

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  • Prognostic Factors in the Acute Exacerbation of Idiopathic Pulmonary Fibrosis: A Retrospective Single-center Study. Reviewed

    Kenichiro Atsumi, Yoshinobu Saito, Naoyuki Kuse, Kenichi Kobayashi, Toru Tanaka, Takeru Kashiwada, Minoru Inomata, Nariaki Kokuho, Hiroki Hayashi, Koichiro Kamio, Kazue Fujita, Shinji Abe, Arata Azuma, Kaoru Kubota, Akihiko Gemma

    Internal medicine (Tokyo, Japan)   57 ( 5 )   655 - 661   2018.3

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    Objectives Acute exacerbation of idiopathic pulmonary fibrosis (IPF-AE) has been recognized as a fatal pulmonary disorder, but the exact prognostic factors are unknown. The aim of the present study was to analyze the clinical characteristics of patients with IPF-AE and identify the prognostic factors. Methods The medical records of 59 cases of IPF-AE were retrospectively reviewed. Clinical data, laboratory data, radiographic findings, treatment, and time from the onset of symptoms to the initiation of corticosteroid pulse therapy, i.e. symptom duration, and outcome were analyzed. Results The IPF Stage, Gender-Age-Physiology (GAP) Index, symptom duration, and the high-resolution computed tomography (HRCT) score were significantly related to the prognosis in the univariate analysis. In the multivariate analysis, the symptom duration remained a significant prognostic factor (hazard ratio of 1-day increase, 1.11; 95% confidence interval, 1.01-1.15; p=0.0427). The area under the receiver operating characteristics curve of symptom duration was statistically significant for survivors versus non-survivors (area under the curve, 0.73; p=0.012). The survival period was significantly shorter in the late-treatment groups (≥5 days; n=30) than in the early-treatment groups (<5 days; n=29; log-rank test; p<0.0001). Conclusion The time interval between the onset of symptoms and the initiation of corticosteroid pulse therapy may be an independent prognostic factor in patients with IPF-AE.

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  • Prognostic Factors in the Acute Exacerbation of Idiopathic Pulmonary Fibrosis: A Retrospective Single-center Study.

    Atsumi Kenichiro, Saito Yoshinobu, Kuse Naoyuki, Kobayashi Kenichi, Tanaka Toru, Kashiwada Takeru, Inomata Minoru, Kokuho Nariaki, Hayashi Hiroki, Kamio Koichiro, Fujita Kazue, Abe Shinji, Azuma Arata, Kubota Kaoru, Gemma Akihiko

    Internal medicine (Tokyo, Japan)   57 ( 5 )   655 - 661   2018.3

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    Objectives Acute exacerbation of idiopathic pulmonary fibrosis (IPF-AE) has been recognized as a fatal pulmonary disorder, but the exact prognostic factors are unknown. The aim of the present study was to analyze the clinical characteristics of patients with IPF-AE and identify the prognostic factors. Methods The medical records of 59 cases of IPF-AE were retrospectively reviewed. Clinical data, laboratory data, radiographic findings, treatment, and time from the onset of symptoms to the initiation of corticosteroid pulse therapy, i.e. symptom duration, and outcome were analyzed. Results The IPF Stage, Gender-Age-Physiology (GAP) Index, symptom duration, and the high-resolution computed tomography (HRCT) score were significantly related to the prognosis in the univariate analysis. In the multivariate analysis, the symptom duration remained a significant prognostic factor (hazard ratio of 1-day increase, 1.11; 95% confidence interval, 1.01-1.15; p=0.0427). The area under the receiver operating characteristics curve of symptom duration was statistically significant for survivors versus non-survivors (area under the curve, 0.73; p=0.012). The survival period was significantly shorter

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  • Granuloma-forming interstitial pneumonia induced by nivolumab: a possible immune-related adverse event of the lung. International journal

    Takeru Kashiwada, Yoshinobu Saito, Yuji Minegishi, Nariaki Kokuho, Akihiko Takahashi, Satoshi Takahashi, Kenichiro Atsumi, Masahiro Seike, Arata Azuma, Kaoru Kubota, Yasuhiro Terasaki, Akihiko Gemma

    International cancer conference journal   6 ( 3 )   131 - 134   2017.7

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    Nivolumab, a monoclonal antibody targeting the PD-1, has recently been used as a standard treatment for lung cancer, melanoma and renal cell carcinoma. We herein report the case of a patient undergoing treatment for non-small cell lung cancer (NSCLC) who developed interstitial pneumonia which featured nivolumab-induced granuloma formation. An 82-year-old male patient with NSCLC was initially treated with radiation therapy and chemotherapy. Five years later, however, he developed metastatic carcinoma in a hilar lymph node accompanied by ground glass opacity (GGO), suggesting tumor cell invasion. Treatment with nivolumab was initiated. At 21 days after the first dose of nivolumab, he complained of cough and dyspnea. Chest computed tomography scans demonstrated tumor progression and newly formed GGO in the area surrounding the primary tumor. Fibrosing active alveolitis with granuloma formation and organizing pneumonia findings were observed in the pathological examination of a transbronchial lung biopsy (TBLB) specimen. No malignant cells were found in TBLB. A bacteriological analysis of cultures, a PCR, and special staining did not reveal any infections. The patient's pneumonitis improved after treatment with systemic corticosteroids. Granuloma-forming interstitial pneumonia may be a feature of nivolumab-associated pneumonitis.

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  • XPLN is modulated by HDAC inhibitors and negatively regulates SPARC expression by targeting mTORC2 in human lung fibroblasts. International journal

    Koichiro Kamio, Arata Azuma, Jiro Usuki, Kuniko Matsuda, Minoru Inomata, Nobuhiko Nishijima, Shioto Itakura, Hiroki Hayashi, Takeru Kashiwada, Nariaki Kokuho, Kenichiro Atsumi, Tomoyoshi Yamaguchi, Kazue Fujita, Yoshinobu Saito, Shinji Abe, Kaoru Kubota, Akihiko Gemma

    Pulmonary pharmacology & therapeutics   44   61 - 69   2017.6

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    Pathogenesis of idiopathic pulmonary fibrosis (IPF) remains unclear. Secreted protein acidic and rich in cysteine (SPARC) is a matricellular protein that participates in the assembly and turnover of the extracellular matrix, whose expression is regulated by transforming growth factor (TGF)-β1 through activation of mammalian target of rapamycin complex 2 (mTORC2). Exchange factor found in platelets, leukemic, and neuronal tissues (XPLN) is an endogenous inhibitor of mTORC2. However, whether XPLN modulates SPARC expression remains unknown. Herein, we investigated the regulatory mechanisms of XPLN in human lung fibroblasts. Effect of XPLN on mTORC2 activity was evaluated by silencing XPLN in human foetal lung fibroblasts (HFL-1 cells), using small interfering RNA. SPARC expression was quantified by quantitative real-time RT-PCR and western blotting. Fibroblasts were treated with TGF-β1, histone deacetylase (HDAC) inhibitors, entinostat, or vorinostat, to assess their effects on XPLN expression. Moreover, the effect of mTORC1 inhibition on SPARC and XPLN was examined. XPLN depletion stimulated SPARC expression and Akt phosphorylation on Ser473. TGF-β1 treatment down-regulated XPLN via Smad 2/3. XPLN mRNA expression was up-regulated upon treatment with HDAC inhibitors in a concentration-dependent manner, and TGF-β1-induced SPARC expression was reversed by entinostat treatment. mTORC1 inhibition by rapamycin and Raptor depletion stimulated SPARC expression. In conclusion, this is the first study describing the involvement of XPLN in the regulation of SPARC. These findings may help uncover the regulatory mechanisms of the mTORC2-SPARC axis. The up-regulation of XPLN by HDAC inhibitors may be a novel therapeutic approach in patients with IPF.

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  • XPLN is modulated by HDAC inhibitors and negatively regulates SPARC expression by targeting mTORC2 in human lung fibroblasts Reviewed

    Koichiro Kamio, Arata Azuma, Jiro Usuki, Kuniko Matsuda, Minoru Inomata, Nobuhiko Nishijima, Shioto Itakura, Hiroki Hayashi, Takeru Kashiwada, Nariaki Kokuho, Kenichiro Atsumi, Tomoyoshi Yamaguchi, Kazue Fujita, Yoshinobu Saito, Shinji Abe, Kaoru Kubota, Akihiko Gemma

    PULMONARY PHARMACOLOGY & THERAPEUTICS   44   61 - 69   2017.6

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    Pathogenesis of idiopathic pulmonary fibrosis (IPF) remains unclear. Secreted protein acidic and rich in cysteine (SPARC) is a matricellular protein that participates in the assembly and turnover of the extra cellular matrix, whose expression is regulated by transforming growth factor (TGF)-beta 1 through activation of mammalian target of rapamycin complex 2 (mTORC2). Exchange factor found in platelets, leukemic, and neuronal tissues (XPLN) is an endogenous inhibitor of mTORC2. However, whether XPLN modulates SPARC expression remains unknown. Herein, we investigated the regulatory mechanisms of XPLN in human lung fibroblasts. Effect of XPLN on mTORC2 activity was evaluated by silencing XPLN in human foetal lung fibroblasts (HFL-1 cells), using small interfering RNA. SPARC expression was quantified by quantitative real-time RT-PCR and western blotting. Fibroblasts were treated with TGF-beta 1, histone deacetylase (HDAC) inhibitors, entinostat, or vorinostat, to assess their effects on XPLN expression. Moreover, the effect of mTORC1 inhibition on SPARC and XPLN was examined. XPLN depletion stimulated SPARC expression and Akt phosphorylation on Ser473. TGF-beta 1 treatment down-regulated XPLN via Smad 2/3. XPLN mRNA expression was up-regulated upon treatment with HDAC inhibitors in a concentration dependent manner, and TGF-beta 1-induced SPARC expression was reversed by entinostat treatment. mTORC1 inhibition by rapamycin and Raptor depletion stimulated SPARC expression. In conclusion, this is the first study describing the involvement of XPLN in the regulation of SPARC. These findings may help uncover the regulatory mechanisms of the mTORC2-SPARC axis. The up-regulation of XPLN by HDAC inhibitors may be a novel therapeutic approach in patients with IPF. (C) 2017 Elsevier Ltd. All rights reserved.

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  • BODY MASS INDEX AND ARTERIAL BLOOD OXYGENATION AS PROGNOSTIC FACTORS IN PATIENTS WITH IDIOPATHIC PLEUROPARENCHYMAL FIBROELASTOSIS

    Hiroki Hayashi, Takahito Nei, Shinji Abe, Yoshinobu Saito, Nariaki Kokuho, Kenichiro Atsumi, Kazue Fujita, Takefumi Saito, Takahiro Tanaka, Akihiko Gemma, Arata Azuma

    SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES   34 ( 1 )   35 - 40   2017

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    Background: Idiopathic pleuroparenchymal fibroelastosis (IPPFE) was recently proposed as an entity to be included among rare idiopathic interstitial pneumonias (IIPs). However, the cause, clinical features and prognosis of this rare entity have not been elucidated. Objectives: We aimed to examine the clinical features, outcomes and prognostic factors for IPPFE in comparison to those of idiopathic pulmonary fibrosis (IPF). Methods: We retrospectively analyzed 20 patients with IPPFE and 71 with IPF. We compared clinical features, blood examination data, and respiratory functions at the time of diagnosis. Results: The IPPFE group had a significantly lower body mass index (BMI), percent forced vital capacity (% FVC), total lung capacity (% TLC) and expiratory reserve volume (% ERV), as well as a higher residual volume to TLC (RV/TLC) ratio than the IPF group. The annual FVC changes in the IPPFE group (-326ml/year) were significantly larger than those in the IPF group (-142ml/year). Survival was significantly poorer in the IPPFE than in the IPF group (P = 0.021). BMI and the partial pressure of oxygen in arterial blood (PaO2) were significantly related to the outcome of IPPFE. Conclusions: Our present results indicate the prognosis of IPPFE patients to be poorer than that of IPF patients. We advocate that BMI and arterial blood PaO2 be determined at the first visit as these parameters are closely related to patients' outcomes. Prospective evaluation of IPPFE starting in the subclinical phase is necessary to assure that appropriate measures are taken before progression.

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  • 癌性胸膜炎に対する滅菌調整タルクとOK-432による胸膜癒着術の後方視的比較検討

    小林 研一, 清家 正博, 高橋 明子, 渥美 健一郎, 武内 進, 松本 優, 野呂 林太郎, 峯岸 裕司, 久保田 馨, 弦間 昭彦

    日本呼吸器学会誌 = Annals of the Japanese Respiratory Society   5 ( 6 )   297 - 301   2016.11

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  • Interstitial lung disease associated with amrubicin chemotherapy in patients with lung cancer: a single institutional study.

    Miura Yukiko, Saito Yoshinobu, Atsumi Kenichiro, Takeuchi Susumu, Miyanaga Akihiko, Mizutani Hideaki, Minegishi Yuji, Noro Rintaro, Seike Masahiro, Shinobu Kunugi, Kubota Kaoru, Gemma Akihiko

    Japanese journal of clinical oncology   46 ( 7 )   674 - 80   2016.7

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    Amrubicin, which is used as a chemotherapeutic agent for lung cancer, can induce interstitial lung disease. There is insufficient evidence on the incidence of amrubicin-associated interstitial lung disease under practical use settings. We therefore investigated the occurrence of interstitial lung disease in the patients with lung cancer who received amrubicin in our institution.We reviewed the data of all patients with lung cancer who received amrubicin at the Nippon Medical School Hospital from March 2002 to April 2015. Interstitial lung disease was diagnosed based on clinical symptoms, radiographic findings and the exclusion of other diseases.We reviewed 92 consecutive patients with lung cancer. Amrubicin-associated interstitial lung disease occurred in 3 of the 92 patients (3.3%): 2 were definite interstitial lung disease and 1 was possible interstitial lung disease. The severity of interstitial lung disease was mild to moderate, and interstitial lung disease improved with or without corticosteroid therapy in all cases. The findings in a computed tomography image analysis showed preexisting pulmonary fibrosis (n = 13), including interstitial pneumonitis (n = 10) and radiat

    DOI: 10.1093/jjco/hyw043

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  • Interstitial lung disease associated with amrubicin chemotherapy in patients with lung cancer: a single institutional study. Reviewed International journal

    Yukiko Miura, Yoshinobu Saito, Kenichiro Atsumi, Susumu Takeuchi, Akihiko Miyanaga, Hideaki Mizutani, Yuji Minegishi, Rintaro Noro, Masahiro Seike, Kunugi Shinobu, Kaoru Kubota, Akihiko Gemma

    Japanese journal of clinical oncology   46 ( 7 )   674 - 80   2016.7

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    OBJECTIVE: Amrubicin, which is used as a chemotherapeutic agent for lung cancer, can induce interstitial lung disease. There is insufficient evidence on the incidence of amrubicin-associated interstitial lung disease under practical use settings. We therefore investigated the occurrence of interstitial lung disease in the patients with lung cancer who received amrubicin in our institution. METHODS: We reviewed the data of all patients with lung cancer who received amrubicin at the Nippon Medical School Hospital from March 2002 to April 2015. Interstitial lung disease was diagnosed based on clinical symptoms, radiographic findings and the exclusion of other diseases. RESULTS: We reviewed 92 consecutive patients with lung cancer. Amrubicin-associated interstitial lung disease occurred in 3 of the 92 patients (3.3%): 2 were definite interstitial lung disease and 1 was possible interstitial lung disease. The severity of interstitial lung disease was mild to moderate, and interstitial lung disease improved with or without corticosteroid therapy in all cases. The findings in a computed tomography image analysis showed preexisting pulmonary fibrosis (n = 13), including interstitial pneumonitis (n = 10) and radiation fibrosis (n = 3). No patients showed the presence of honeycomb lung. Among the 13 patients, 1 (7.7%) developed interstitial lung disease after amrubicin chemotherapy. CONCLUSION: Interstitial lung disease occurred in 3.3% of the patients in our study; this appeared to be less frequent than the rates in previous reports. Preexisting pulmonary fibrosis may be a risk factor for interstitial lung disease; however, no fatal cases were found among the patients with asymptomatic pulmonary fibrosis without honeycomb lung. It is thus considered to be necessary to carefully assess the possibility of preexisting pulmonary fibrosis and clarify the presence or absence of honeycomb lung before starting amrubicin chemotherapy.

    DOI: 10.1093/jjco/hyw043

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  • Crizotinib-induced severe ulcerative esophagitis three years after chemoradiotherapy

    Kenichiro Atsumi, Yuji Minegishi, Natsuki Takano, Miwako Omori, Yoshinobu Saito, Masahiro Seike, Arata Azuma, Kaoru Kubota, Akihiko Gemma

    International Cancer Conference Journal   4 ( 4 )   221 - 224   2015.10

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    DOI: 10.1007/s13691-014-0205-3

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  • 当院における肺原発MALT lymphoma二切除例の検討

    竹ヶ原 京志郎, 鳥山 紗由子, 佐藤 明, 揖斐 孝之, 井上 達哉, 石角 太一郎, 渥美 健一郎, 森本 泰介, 弦間 昭彦, 臼田 実男

    肺癌   55 ( 5 )   507 - 507   2015.10

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  • 中葉症候群と鑑別を要した肺原発MALT lymphomaの1切除例

    竹ヶ原 京志郎, 井上 達哉, 鳥山 紗由子, 佐藤 明, 揖斐 孝之, 石角 太一郎, 臼田 実男, 渥美 健一郎, 弦間 昭彦

    肺癌   55 ( 4 )   299 - 300   2015.8

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  • CPC 日常臨床から学ぶ この症例の新しい意義は? 緊張性気胸様変化を呈した肺気腫・巨大肺嚢胞の1例

    根井 貴仁, 茂木 孝, 重盛 朋子, 渥美 健一郎, 武内 進, 斉藤 好信, 篠田 欣也, 工藤 翔二, 中山 智子

    THE LUNG-perspectives   13 ( 3 )   222 - 226   2005.7

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    85歳男.四肢脱力感,歩行困難を主訴とした.79歳より慢性閉塞性肺疾患(COPD)の経過観察をされ,81歳より進行膀胱癌(移行上皮癌)でフルオロウラシル製剤内服を継続していた.入院時検査にて低カリウム血症,胸部単純X線・CT各所見にて両肺に高度な気腫性変化をび漫性に認め,左肺は巨大肺嚢胞および胸水の貯留を認めた.また,頭部CTより小脳虫部に腫瘤病変を認めた.胸水は第2病日の試験穿刺より漏出性胸水と診断し,穿刺後SpO2が低下し緊張性気胸様状態となった.緊急胸腔ドレナージにて一時的に改善したが,意識状態が悪化し第3病日目に死亡した.剖検の結果,肺気腫,膀胱癌の多発転移,癌性リンパ管症,右腎結核,右心拡張・左室肥大であった.なお,四肢脱力感は低カリウム血症に因るものと推察した

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Books

  • 呼吸器内科グリーンノート

    ( Role: ContributorⅠ.3. 4) 明らかな肺内異常陰影のない呼吸困難 IV. 4. 輸液療法 5. 経管栄養法 V.2. 5)原発性線毛機能不全症)

    中外医学社  2020.10 

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  • 炎症と免疫

    ( Role: Contributor間質性肺炎:診断と治療 間質性肺炎の新しい治療)

    先端医学社  2020.10 

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  • 日常臨床に活かす診療ガイドライン UP-TO-DATE 2020-2021

    渥美健一郎, 吾妻安良太( Role: ContributorII呼吸器疾患 9. 間質性肺炎(特発性・膠原病性・薬剤性))

    メディカルレビュー社  2020.2 

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    Responsible for pages:135-142   Language:Japanese  

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  • 気管支鏡テキスト 第3版

    渥美健一郎, 阿部信二( Role: Contributor第Ⅴ章 各種疾患の気管支鏡所見と診断 血管炎)

    医学書院  2019.4 

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  • 呼吸器疾患最新の治療 2019-2020

    渥美健一郎, 木村弘( Role: Contributor肺動脈性肺高血圧症)

    南江堂  2019.4 

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  • 日常臨床に活かす診療ガイドライン UP-TO-DATE 2018-2019

    渥美健一郎, 吾妻安良太( Role: ContributorII呼吸器疾患 9. 間質性肺炎(特発性・膠原病性・薬剤性))

    メディカルレビュー社  2018.1 

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    Responsible for pages:113-120   Language:Japanese  

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  • 呼吸器疾患-最新の薬物療法-2

    渥美健一郎, 吾妻安良太( Role: ContributorIV間質性肺炎 第4章 抗線維化薬(ピルフェニドン,ニンテダニブ))

    克誠堂出版  2017.1 

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    Responsible for pages:170-175   Language:Japanese   Book type:Scholarly book

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  • 月刊 リウマチ科 第55巻 第4号

    渥美 健一郎, 吾妻 安良太( Role: Contributor膠原病と薬剤性肺障害)

    科学評論社  2016.4 

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    Responsible for pages:398-403   Language:Japanese   Book type:Scholarly book

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  • 呼吸器疾患 最新の治療 2016-2018

    渥美 健一郎, 吾妻 安良太( Role: ContributorIII呼吸器疾患の治療手技5.抗炎症・免疫抑制薬(マクロライドも含む))

    南江堂  2016.3 

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    Responsible for pages:82-87   Language:Japanese   Book type:Scholarly book

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  • 日常臨床に活かす診療ガイドライン UP-TO-DATE 2016-2017

    渥美 健一郎, 吾妻 安良太( Role: Contributor呼吸器疾患 6.間質性肺炎(特発性・膠原病性・薬剤性))

    メディカルレビュー社  2016.2 

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    Responsible for pages:105-112   Language:Japanese   Book type:Scholarly book

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  • 新しい診断と治療のABC 85 全身性疾患の肺病変

    渥美 健一郎, 吾妻 安良太( Role: Contributor肺ランゲルハンス細胞組織球症)

    最新医学社  2015.9 

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    Responsible for pages:170-176   Language:Japanese   Book type:Scholarly book

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  • 【くすりの副作用のすべて】 病態からみたくすりの副作用 呼吸器系(薬剤性肺障害) その概要と最近の知見

    渥美 健一郎, 吾妻 安良太( Role: Contributor)

    医歯薬出版  2014.11 

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  • 月刊 呼吸器内科 第24巻 第4号 【マクロライド療法30年:現状と将来を考える】

    渥美 健一郎, 吾妻 安良太( Role: Contributor「好中球性炎症性気道疾患」とは何か,どう用いるか)

    科学評論社  2013.10 

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    Responsible for pages:24:304-24:309   Language:Japanese   Book type:Scholarly book

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Misc.

  • Nivolumab+Ipilimumab投与中に胸膜炎症状のpseudoprogressionを呈した胸膜播種を伴う肺癌の1例

    寺嶋 勇人, 渥美 健一郎, 寺師 直樹, 鈴木 彩奈, 久金 翔, 廣瀬 敬, 永田 耕治

    肺癌   62 ( 3 )   269 - 269   2022.6

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  • Analysis of %FVC/%DLco ratio for pulmonary hypertension associated with interstitial pneumonia

    渥美健一郎, 渥美健一郎, 田中徹, 柏田建, 田中庸介, 齋藤好信, 藤田和恵, 廣瀬敬, 清家正博, 吾妻安良太, 木村弘, 木村弘, 弦間昭彦

    日本呼吸器学会誌(Web)   10   2021

  • 気管支鏡にて診断した汎血球減少改善に伴い発症したメトトレキサート肺炎の1例

    芳賀 三四郎, 田中 徹, 湯浅 瑞希, 清水 理光, 二島 駿一, 柏田 建, 渥美 健一郎, 田中 庸介, 齋藤 好信, 寺崎 泰弘, 木村 弘, 久保田 馨, 清家 正博, 弦間 昭彦

    気管支学   42 ( 1 )   99 - 99   2020.1

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  • トシリズマブ中断後に多房性膿胸を発症した若年性特発性関節炎の1例

    鈴木 幹人, 名和田 隆司, 櫻庭 未多, 大田 ゆう子, 白井 悠一郎, 五野 貴久, 岳野 光洋, 渥美 健一郎, 林 宏紀, 桑名 正隆

    日本内科学会関東地方会   656回   43 - 43   2019.12

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  • 早期治療介入をするも難治性末梢神経障害と大腸潰瘍を来したEGPAの1例

    千田 絵里佳, 渥美 健一郎, 林 杏奈, 清水 理光, 二島 駿一, 田中 徹, 柏田 建, 林 宏紀, 藤田 和恵, 寺崎 泰弘, 櫻井 侑美, 谷口 泰之, 齋藤 好信, 木村 弘, 清家 正博, 弦間 昭彦

    日本結核病学会関東支部学会・日本呼吸器学会関東地方会合同学会プログラム・抄録集   176回・236回   27 - 27   2019.9

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  • EBUS-TBNA後に気管支内穿破,内腔にポリープ状の隆起性病変を来たした結核性リンパ節炎の1例

    久金 翔, 藤田 和恵, 菅野 哲平, 高野 夏希, 二島 駿一, 高橋 聡, 田中 徹, 柏田 建, 渥美 健一郎, 武内 進, 宮永 晃彦, 林 宏紀, 齋藤 好信, 久保田 馨, 木村 弘, 清家 正博, 弦間 昭彦

    2019.7

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  • 当院における気管支サーモプラスティの使用経験

    北川 真吾, 林 宏紀, 高野 夏希, 二島 駿一, 久金 翔, 高橋 聡, 田中 徹, 柏田 建, 菅野 哲平, 渥美 健一郎, 藤田 和恵, 齋藤 好信, 木村 弘, 久保田 馨, 清家 正博, 弦間 昭彦

    2019.7

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  • 特発性肺線維症急性増悪例の分類改定案の自験例による検証

    柏田 建, 齋藤 好信, 渥美 健一郎, 戸塚 猛大, 田中 徹, 林 宏紀, 神尾 孝一郎, 藤田 和恵, 木村 弘, 久保田 馨, 吾妻 安良太, 清家 正博, 弦間 昭彦

    日本呼吸器学会誌   8 ( 増刊 )   196 - 196   2019.3

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  • 特発性肺線維症急性増悪例の分類改定案の自験例による検証

    柏田 建, 齋藤 好信, 渥美 健一郎, 戸塚 猛大, 田中 徹, 林 宏紀, 神尾 孝一郎, 藤田 和恵, 木村 弘, 久保田 馨, 吾妻 安良太, 清家 正博, 弦間 昭彦

    日本呼吸器学会誌   8 ( 増刊 )   196 - 196   2019.3

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  • 肺疾患に伴う肺高血圧症に対する肺換気血流SPECT/CTによる治療評価

    渥美 健一郎, 林 宏紀, 二島 駿一, 田中 徹, 蛸井 浩行, 柏田 建, 藤田 和恵, 齋藤 好信, 清家 正博, 弦間 昭彦, 久保田 芳明, 福嶋 善光, 木村 弘

    日本呼吸器学会誌   8 ( 増刊 )   307 - 307   2019.3

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  • 肺疾患に伴う肺高血圧症に対する肺換気血流SPECT/CTによる治療評価

    渥美 健一郎, 林 宏紀, 二島 駿一, 田中 徹, 蛸井 浩行, 柏田 建, 藤田 和恵, 齋藤 好信, 清家 正博, 弦間 昭彦, 久保田 芳明, 福嶋 善光, 木村 弘

    日本呼吸器学会誌   8 ( 増刊 )   307 - 307   2019.3

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  • 肺の多発結節影を認め、レミエール症候群と診断した2例

    芳賀 三四郎, 林 宏紀, 宮下 稜太, 鈴木 彩奈, 戸塚 猛大, 渥美 健一郎, 齋藤 好信, 木村 弘, 清家 正博, 弦間 昭彦

    日本内科学会関東地方会   646回   35 - 35   2018.11

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  • 当科におけるEBUS-GSでの診断率に関する検討

    戸塚 猛大, 鏑木 翔太, 北川 真吾, 高野 賢治, 高橋 彬彦, 高野 夏希, 久金 翔, 高橋 聡, 蛸井 浩行, 田中 徹, 柏田 建, 菅野 哲平, 渥美 健一郎, 武内 進, 林 宏紀, 峯岸 裕司, 野呂 林太郎, 齋藤 好信, 久保田 馨, 清家 正博, 弦間 昭彦

    気管支学   40 ( Suppl. )   S204 - S204   2018.5

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  • 当院におけるEBUS-TBNAの診断率と関連因子の検討

    渥美 健一郎, 林 宏紀, 鏑木 翔太, 久金 翔, 田中 徹, 蛸井 浩行, 柏田 建, 國保 成暁, 藤田 和恵, 齋藤 好信, 阿部 信二, 木村 弘, 久保田 馨, 清家 正博, 弦間 昭彦

    気管支学   40 ( Suppl. )   S200 - S200   2018.5

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  • 非小細胞肺癌へ対するnab‐Paclitaxel療法による薬剤性肺障害の検討

    柏田建, 齋藤好信, 高橋聡, 小林研一, 渥美健一郎, 菅野哲平, 武内進, 林宏紀, 野呂林太郎, 峯岸裕司, 藤田和恵, 阿部信二, 清家正博, 久保田馨, 弦間昭彦

    日本呼吸器学会誌(Web)   7 ( 増刊 )   235 - 235   2018.3

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    J-GLOBAL

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  • エクソソーム由来microRNAの肺線維化マーカー抑制効果に関する検討

    猪俣 稔, 神尾 孝一郎, 吾妻 安良太, 松田 久仁子, 柏田 建, 國保 成暁, 渥美 健一郎, 林 宏紀, 藤田 和恵, 齋藤 好信, 阿部 信二, 弦間 昭彦

    日本呼吸器学会誌   7 ( 増刊 )   166 - 166   2018.3

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  • 非小細胞肺癌へ対するnab-Paclitaxel療法による薬剤性肺障害の検討

    柏田 建, 齋藤 好信, 高橋 聡, 小林 研一, 渥美 健一郎, 菅野 哲平, 武内 進, 林 宏紀, 野呂 林太郎, 峯岸 裕司, 藤田 和恵, 阿部 信二, 清家 正博, 久保田 馨, 弦間 昭彦

    日本呼吸器学会誌   7 ( 増刊 )   235 - 235   2018.3

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  • 非小細胞肺癌へ対するnab-Paclitaxel療法による薬剤性肺障害の検討

    柏田 建, 齋藤 好信, 高橋 聡, 小林 研一, 渥美 健一郎, 菅野 哲平, 武内 進, 林 宏紀, 野呂 林太郎, 峯岸 裕司, 藤田 和恵, 阿部 信二, 清家 正博, 久保田 馨, 弦間 昭彦

    日本呼吸器学会誌   7 ( 増刊 )   235 - 235   2018.3

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  • 過粘稠性肺炎桿菌による重症肺炎・肺膿瘍の2例

    鏑木 翔太, 蛸井 浩行, 田中 徹, 渥美 健一郎, 林 宏紀, 藤田 和恵, 斎藤 好信, 阿部 信二, 木村 弘, 久保田 馨, 清家 正博, 弦間 昭彦

    日本結核病学会関東支部学会・日本呼吸器学会関東地方会合同学会プログラム・抄録集   173回・228回   29 - 29   2018.2

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  • 関節リウマチに対するMTXの内服中止に伴ってサルコイドーシスが顕在化した1例

    宮下稜太, 林宏紀, 鈴木彩奈, 戸塚猛大, 渥美健一郎, 齋藤好信, 木村弘, 清家正博, 弦間昭彦, 寺崎泰弘

    日本内科学会関東支部関東地方会   646th   33   2018

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  • 金属加工業者に発症し、DLST、HLA-DPB1アレルより診断した慢性ベリリウム肺の一例

    柏田 建, 阿部 信二, 蛸井 浩行, 渥美 健一郎, 林 宏紀, 藤田 和恵, 齋藤 好信, 弦間 昭彦, 久保田 馨, 國保 成暁, 寺崎 泰弘, 吾妻 安良太

    日本サルコイドーシス/肉芽腫性疾患学会雑誌   37 ( 1-2 )   69 - 69   2017.10

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  • 日本医科大学付属病院総合診療センターにおける感染症診療の現状と課題

    須崎 真, 藤田 和恵, 渥美 健一郎, 林 宏紀, 小野寺 直子, 兵働 英也, 小原 俊彦, 宮内 雅人, 齋藤 好信, 弦間 昭彦, 安武 正弘

    感染症学雑誌   91 ( 3 )   459 - 459   2017.5

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  • EBUS-TBNA後に生じた縦隔炎の2症例

    高橋 聡, 渥美 健一郎, 樋口 明日香, 矢嶋 知佳, 中山 幸治, 蓮見 健太, 青山 純一, 久世 眞之, 小林 研一, 蛸井 浩行, 高橋 明子, 柏田 建, 揖斐 孝之, 武内 進, 井上 達哉, 林 宏紀, 藤田 和恵, 齋藤 好信, 清家 正博, 臼田 実男, 久保田 馨, 弦間 昭彦

    気管支学   39 ( Suppl. )   S385 - S385   2017.5

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  • ニボルマブによる薬剤性肺障害症例の検討

    柏田建, 齋藤好信, 峯岸裕司, 蛸井浩行, 渥美健一郎, 武内進, 松本優, 林宏紀, 野呂林太郎, 阿部信二, 藤田和恵, 清家正博, 吾妻安良太, 久保田馨, 弦間昭彦

    日本呼吸器学会誌(Web)   6 ( 増刊 )   183 - 183   2017.3

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  • 肺MAC症治療効果判定における抗MAC抗体の有用性の検討

    蛸井 浩行, 矢嶋 知佳, 柏田 建, 渥美 健一郎, 林 宏紀, 藤田 和恵, 齋藤 好信, 阿部 信二, 吾妻 安良太, 弦間 昭彦, 久保田 馨

    日本呼吸器学会誌   6 ( 増刊 )   322 - 322   2017.3

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  • ニボルマブによる薬剤性肺障害症例の検討

    柏田 建, 齋藤 好信, 峯岸 裕司, 蛸井 浩行, 渥美 健一郎, 武内 進, 松本 優, 林 宏紀, 野呂 林太郎, 阿部 信二, 藤田 和恵, 清家 正博, 吾妻 安良太, 久保田 馨, 弦間 昭彦

    日本呼吸器学会誌   6 ( 増刊 )   183 - 183   2017.3

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  • 慢性線維性間質性肺炎に対するnintedanib投与例の臨床的検討

    林 宏紀, 矢嶋 知佳, 蛸井 浩行, 柏田 建, 渥美 健一郎, 國保 成暁, 藤田 和恵, 神尾 孝一郎, 齋藤 好信, 阿部 信二, 弦間 昭彦, 久保田 馨, 吾妻 安良太

    日本呼吸器学会誌   6 ( 増刊 )   212 - 212   2017.3

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  • Pseudoprogressionと判断されたNivolumabによる肺障害の1例

    須賀 実佑里, 峯岸 裕司, 高橋 彬彦, 高橋 聡, 渥美 健一郎, 久保田 馨, 弦間 昭彦

    肺癌   57 ( 1 )   57 - 57   2017.2

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  • 活動性肺結核の治療中に急速に胸水貯留をきたし局所麻酔下胸腔鏡を施行した1例

    矢嶋 知佳, 林 宏紀, 蛸井 浩行, 柏田 建, 渥美 健一郎, 藤田 和恵, 齊藤 好信, 阿部 信二, 吾妻 安良太, 久保田 馨, 弦間 昭彦

    結核   92 ( 1 )   60 - 60   2017.1

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  • 二次化学療法としてカルボプラチン+パクリタキセルが有用であった特発性間質性肺炎合併小細胞肺癌の1例

    中山 幸治, 峯岸 裕司, 小林 研一, 渥美 健一郎, 清家 正博, 弦間 昭彦, 久保田 馨

    肺癌   56 ( 3 )   252 - 252   2016.6

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  • 無気肺を呈したマイコプラズマ肺炎の検討

    佐藤 陽三, 藤田 和恵, 蛸井 弘行, 柏田 建, 國保 成暁, 渥美 健一郎, 林 宏紀, 齋藤 好信, 清家 正博, 久保田 馨, 弦間 昭彦

    気管支学   38 ( Suppl. )   S362 - S362   2016.5

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  • Re-biopsy 当院における肺癌患者に対する再生検の実態調査

    高橋 明子, 清家 正博, 青山 純一, 小林 研一, 柏田 建, 渥美 健一郎, 林 宏紀, 野呂 林太郎, 峯岸 裕司, 藤田 和恵, 齋藤 好信, 久保田 馨, 弦間 昭彦

    気管支学   38 ( Suppl. )   S168 - S168   2016.5

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  • 【膠原病に伴う間質性肺炎】 膠原病と薬剤性肺障害

    渥美 健一郎, 吾妻 安良太

    リウマチ科   55 ( 4 )   398 - 403   2016.4

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  • 75歳以上の進行期非小細胞肺がんに対するAfatinib使用成績

    内藤 智之, 水谷 英明, 高橋 彬彦, 佐藤 陽三, 高橋 明子, 渥美 健一郎, 武内 進, 宮永 晃彦, 峯岸 裕司, 清家 正博, 久保田 馨, 弦間 昭彦

    日本呼吸器学会誌   5 ( 増刊 )   318 - 318   2016.3

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  • 初診時の抗ARS抗体陽性間質性肺炎における臨床的特徴について

    中山 幸治, 林 宏紀, 柏田 建, 齋藤 好信, 三山 江穂, 渥美 健一郎, 國保 成暁, 藤田 和恵, 吾妻 安良太, 久保田 馨, 弦間 昭彦

    日本呼吸器学会誌   5 ( 増刊 )   201 - 201   2016.3

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  • 当院における抗ARS抗体陽性間質性肺炎の臨床病理学的検討

    柏田 建, 根井 貴仁, 齋藤 好信, 中山 幸治, 渥美 健一郎, 林 宏紀, 藤田 和恵, 久保田 馨, 吾妻 安良太, 國保 成暁, 功刀 しのぶ, 寺崎 泰弘, 弦間 昭彦

    日本呼吸器学会誌   5 ( 増刊 )   202 - 202   2016.3

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  • 間質性肺炎合併肺癌 特発性間質性肺炎合併進行非小細胞肺癌に対するカルボプラチン+パクリタキセル療法の認容性試験

    渥美 健一郎, 峯岸 裕司, 高橋 彬彦, 佐藤 陽三, 小林 研一, 高橋 明子, 武内 進, 宮永 晃彦, 水谷 英明, 齋藤 好信, 清家 正博, 久保田 馨, 弦間 昭彦

    肺癌   55 ( 5 )   392 - 392   2015.10

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  • 80歳以上超高齢者肺癌症例の治療方針決定に影響与える因子の検討

    佐藤 陽三, 峯岸 裕司, 高橋 彬彦, 小林 研一, 高橋 明子, 渥美 健一郎, 武内 進, 宮永 晃彦, 水谷 英明, 山本 和男, 清家 正博, 久保田 馨, 弦間 昭彦

    肺癌   55 ( 5 )   433 - 433   2015.10

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  • 75歳以上EGFR遺伝子変異陽性患者に対するAfatinib使用成績

    水谷 英明, 峯岸 裕司, 高橋 彬彦, 佐藤 陽三, 渥美 健一郎, 高橋 明子, 武内 進, 宮永 晃彦, 清家 正博, 久保田 馨, 弦間 昭彦

    肺癌   55 ( 5 )   461 - 461   2015.10

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  • 当院における癌性胸膜炎に対する滅菌調整タルクとOK-432による胸膜癒着術の後方視的検討

    小林 研一, 清家 正博, 佐藤 陽三, 高橋 明子, 渥美 健一郎, 武内 進, 宮永 晃彦, 水谷 英明, 峯岸 裕司, 山本 和男, 久保田 馨, 弦間 昭彦

    肺癌   55 ( 5 )   464 - 464   2015.10

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  • タルクによる胸膜癒着術施行後に肺障害を起こした2症例

    高橋 彬彦, 峯岸 裕司, 小林 研一, 渥美 健一郎, 弦間 昭彦, 吾妻 安良太, 久保田 馨

    肺癌   55 ( 4 )   295 - 295   2015.8

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  • 悪性リンパ腫の肺病変と化学療法中に合併した肺クリプトコッカス症の診断に気管支鏡検査が有用であった1例

    猪俣 稔, 長山 美貴恵, 渥美 健一郎, 林 宏紀, 峯岸 裕司, 藤田 和恵, 斎藤 好信, 清家 正博, 弦間 昭彦

    第38回日本呼吸器内視鏡学会学術集会   37 ( Suppl. )   S310 - S310   2015.5

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    DOI: 10.18907/jjsre.37.Special_S310_2

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  • 大学病院総合診療センターにおける感染症診療の実態に関する検討

    須崎 真, 藤田 和恵, 渥美 健一郎, 林 宏紀, 小野寺 直子, 兵働 英也, 小原 俊彦, 斎藤 好信, 弦間 昭彦, 安武 正弘

    感染症学雑誌   89 ( 臨増 )   303 - 303   2015.3

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  • 肺癌化学療法中における発熱性好中球減少症の臨床的検討

    藤田 和恵, 中道 真仁, 柏田 建, 渥美 健一郎, 林 宏紀, 齋藤 好信, 弦間 昭彦, 久保田 馨, 清家 正博, 峯岸 裕司, 宮永 晃彦, 水谷 英明

    感染症学雑誌   89 ( 1 )   159 - 159   2015.1

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  • 薬剤中止で改善したメサラジンによる薬剤性好酸球性肺炎の1例

    加藤 友美, 小林 研一, 渥美 健一郎, 武内 進, 峯岸 裕司, 齋藤 好信, 吾妻 安良太, 弦間 昭彦

    日本内科学会関東地方会   611回 ( 611 )   61 - 61   2014.12

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  • 【くすりの副作用のすべて】 病態からみたくすりの副作用 呼吸器系(薬剤性肺障害) その概要と最近の知見

    渥美 健一郎, 吾妻 安良太

    医学のあゆみ   251 ( 9 )   726 - 731   2014.11

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    薬剤性肺障害とは、医薬品投与中に起こった呼吸器系の障害のうち、医薬品と関連があると考えられるものの総称である。薬剤性肺障害には特異的な診断方法がないため、日常臨床では診断が困難な場合が少なくない。近年、抗悪性腫瘍薬の種類が年々増加しており、とくに分子標的治療薬の開発がきわだっている。分子標的治療薬には薬剤性肺障害の頻度の高いものが多く、施設を限定した全例調査などにより、精度の高い疫学情報も報告されている。治療は原因薬剤の中止および必要に応じたステロイド投与が原則であるが、mTOR阻害薬のように例外的な対応が要求される薬剤もあり、マネージメントには注意を要する。呼吸器以外の臓器領域で使用される薬剤も多いことから、あらゆる領域の医師が広く情報を共有することが重要である。本稿では薬剤性肺障害を概説するとともに、最近注目される薬剤の肺障害の実態に焦点をあてて述べる。(著者抄録)

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  • ゲフィチニブ投与中にネフローゼ症候群を呈した1例

    小林 由美子, 武内 進, 青山 純也, 加藤 泰裕, 小林 有紀, 佐藤 陽三, 清水 理光, 高野 夏希, 中鉢 久実, 中道 真仁, 渥美 健一郎, 宮永 晃彦, 山本 和男, 藤田 和恵, 峯岸 裕司, 清家 正博, 久保田 馨, 弦間 昭彦

    肺癌   54 ( 3 )   168 - 169   2014.6

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  • 間質性肺炎におけるGallium SPECT-CT検査の有用性

    林 宏紀, 齋藤 好信, 田中 徹, 猪俣 稔, 渥美 健一郎, 三浦 由記子, 國保 成暁, 藤田 和恵, 吾妻 安良太, 弦間 昭彦, 福嶋 善光

    日本呼吸器学会誌   3 ( 増刊 )   318 - 318   2014.3

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  • 当院における特発性肺線維症の急性増悪の予後関連因子の検討

    渥美 健一郎, 齋藤 好信, 三浦 由記子, 國保 成暁, 田中 徹, 林 宏紀, 藤田 和恵, 吾妻 安良太, 弦間 昭彦

    日本呼吸器学会誌   3 ( 増刊 )   164 - 164   2014.3

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  • MPO-ANCA陽性肺病変の臨床的検討

    二島 駿一, 林 宏紀, 田中 徹, 渥美 健一郎, 三浦 由記子, 國保 成暁, 藤田 和恵, 齋藤 好信, 吾妻 安良太, 弦間 昭彦

    日本呼吸器学会誌   3 ( 増刊 )   165 - 165   2014.3

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  • ゲフィチニブ投与中にネフローゼ症候群を呈した1例

    小林由美子, 武内進, 青山純也, 加藤泰裕, 小林有紀, 佐藤陽三, 清水理光, 高野夏希, 中鉢久実, 中道真仁, 渥美健一郎, 宮永晃彦, 山本和男, 藤田和恵, 峯岸裕司, 清家正博, 久保田馨, 弦間昭彦

    肺癌(Web)   54 ( 3 )   168-169(J-STAGE)   2014

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    J-GLOBAL

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  • LONGER DELAYS IN DIAGNOSIS OF TUBERCULOSIS IN A TOKYO METROPOLITAN AREA

    Kazue Fujita, Kazuhiro Kitamura, Kosuke Narita, Kenichiro Atsumi, Yukiko Miura, Hiroki Hayashi, Yoshinobu Saito, Arata Azuma, Akihiko Gemma

    RESPIROLOGY   18   9 - 9   2013.11

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    Web of Science

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  • 【マクロライド療法30年:現状と将来を考える】 「好中球性炎症性気道疾患」とは何か、どう用いるか

    渥美 健一郎, 吾妻 安良太

    呼吸器内科   24 ( 4 )   304 - 309   2013.10

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    CiNii Books

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    Other Link: http://search.jamas.or.jp/link/ui/2014041109

  • EVALUATION OF DIAGNOSTIC PERFORMANCE IN PATIENTS WHO UNDERWENT BRONCHOSCOPY FOR DIAGNOSIS OF SARCOIDOSIS

    K. Atsumi, Y. Tanaka, M. Hino, K. Hisakane, H. Kuribayashi, S. Kosaihira, A. Gemma

    RESPIROLOGY   17   75 - 75   2012.12

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  • NEW ASSESSMENT METHODS FOR AIRWAY LESIONS (WITHOUT SPIROMETRY)

    Y. Tanaka, K. Atsumi, M. Hino, H. Kuribayashi, K. Hisakane, S. Kosaihira, A. Gemma

    RESPIROLOGY   17   34 - 34   2012.12

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  • EVALUATION OF RIGHT VENTRICULAR FUNCTION ASSESSED IN AWAKENED PATIENTS WITH OBSTRUCTIVE SLEEP DISORDERED BREATHING

    Y. Tanaka, M. Hino, N. Onda, K. Atsumi, H. Kuribayashi, Y. Ono, A. Gemma

    RESPIROLOGY   16   231 - 232   2011.11

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  • 肺多発結節影を呈し胸腔鏡下生検にて診断した肺MALT lymphomaの1例

    渥美 健一郎, 上鶴 里央子, 楢戸 律子, 上原 隆志, 小俣 雅稔, 田中 庸介, 小野 靖, 吉野 直之, 日野 光紀, 大秋 美治

    Journal of Nippon Medical School   71 ( 3 )   235 - 235   2004.6

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  • タルクによる胸膜癒着術施行後に肺障害を起こした2症例

    高橋 彬彦, 峯岸 裕司, 小林 研一, 渥美 健一郎, 弦間 昭彦, 吾妻 安良太, 久保田 馨

    肺癌  2015.8 

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  • 中葉症候群と鑑別を要した肺原発MALT lymphomaの一切除例

    竹ヶ原 京志郎, 井上 達哉, 鳥山 紗由子, 佐藤 明, 揖斐 孝之, 石角 太一郎, 渥美 健一郎, 弦間 昭彦, 臼田 実男

    日本肺癌学会関東支部学術集会(第173回)  2015.7 

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    Venue:東京江東区  

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  • タルクによる胸膜癒着術施行後に肺障害を起こした2例

    高橋 彬彦, 峯岸 裕司, 小林 研一, 渥美 健一郎, 弦間 昭彦, 清家 正博, 吾妻 安良太, 久保田 馨

    日本肺癌学会関東支部会(第173回)  2015.7 

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    Venue:東京都  

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  • タルクによる胸膜癒着術施行後に肺障害を起こした2症例

    髙橋 彬彦, 峯岸 裕司, 小林 研一, 渥美 健一郎, 弦間 昭彦, 吾妻 安良太, 久保田 馨

    日本肺癌学会関東支部会(第173回)  2015.7 

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    Venue:TFTビル西館 HALL500(江東区有明)  

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  • 中葉症候群と鑑別を要した肺原発MALT lymphomaの一切除例

    竹ヶ原 京志郎, 井上 達哉, 鳥山 紗由子, 佐藤 明, 揖斐 孝之, 石角 太一郎, 渥美 健一郎, 弦間 昭彦, 臼田 実男

    日本肺癌学会関東支部学術集会(第173回)  2015.7 

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    Venue:東京江東区  

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  • 悪性リンパ腫の肺病変と化学療法中に合併した肺クリプトコッカス症の診断に気管支鏡検査が有用であった1例

    猪俣 稔, 長山 美貴恵, 渥美 健一郎, 林 宏紀, 峯岸 裕司, 藤田 和恵, 齋藤 好信, 清家 正博, 弦間 昭彦

    日本呼吸器内視鏡学会学術集会(第38回)  2015.6 

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    Venue:東京  

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  • 大学病院総合診療センターにおける感染症診療の実態に関する検討

    須﨑 真, 藤田 和恵, 渥美 健一郎, 林 宏紀, 小野寺 直子, 兵働 英也, 小原 俊彦, 斎藤 好信, 弦間 明彦, 安武 正弘

    日本感染症学会総会・学術講演会(第89回)  2015.4 

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    Venue:京都  

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  • 薬剤中止で改善したメサラジンによる薬剤性好酸球性肺炎の1例

    加藤 友美, 小林 研一, 渥美 健一郎, 武内 進, 峯岸 裕司, 齋藤 好信, 吾妻 安良太, 弦間 昭彦

    日本内科学会関東地方会(第611回)  2014.12 

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    Venue:東京  

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  • 薬剤中止で改善したメサラジンによる薬剤性好酸球性肺炎の1例

    加藤 友美, 小林 研一, 渥美 健一郎, 武内 進, 峯岸 裕司, 齋藤 好信, 吾妻 安良太, 弦間 昭彦

    日本内科学会関東地方会(第611回)  2014.12 

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    Venue:東京  

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  • 肺癌化学療法中における発熱性好中球減少症の臨床的検討

    藤田 和恵, 中道 真仁, 柏田 建, 渥美 健一郎, 林 宏紀, 齋藤 好信, 弦間 昭彦

    日本化学療法学会(第62回)  2014.10 

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    Venue:岡山  

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  • 肺炎球菌性細気管支炎の臨床的検討

    成田 宏介, 藤田 和恵, 渥美 健一郎, 林 宏紀, 齋藤 好信, 弦間 昭彦

    日本感染症学会(第88回)  2014.6 

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    Venue:福岡  

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  • 18F-FDG PET/CTが診断に有用であった結核症例の検討

    藤田 和恵, 渥美 健一郎, 成田 宏介, 林 宏紀, 齋藤 好信, 弦間 昭彦

    日本感染症学会(第88回)  2014.6 

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    Venue:福岡  

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  • 間質性肺炎におけるGallium SPECT-CT検査の有用性

    林 宏紀, 齋藤 好信, 田中 徹, 猪俣 稔, 渥美 健一郎, 三浦 由記子, 國保 成暁, 藤田 和恵, 吾妻 安良太, 弦間 昭彦, 福嶋 善光

    日本呼吸器学会総会学術講演会(第54回)  2014.4 

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  • 肺MAC症治療効果判定における抗MAC抗体の有用性の検討

    蛸井浩行, 矢嶋知佳, 柏田建, 渥美健一郎, 林宏紀, 藤田和恵, 齋藤好信, 阿部信二, 吾妻安良太, 弦間昭彦, 久保田馨

    日本呼吸器学会学術講演会(第57回)  2017.4 

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    Venue:東京  

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  • 慢性線維性間質性肺炎に対するnintedanib投与例の臨床的検討

    林宏紀, 矢嶋知佳, 蛸井浩行, 柏田建, 渥美健一郎, 國保成暁, 藤田和恵, 神尾孝一郎, 齋藤好信, 阿部信二, 弦間昭彦, 久保田馨, 吾妻安良太

    日本呼吸器学会学術講演会(第57回)  2017.4 

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    Venue:東京  

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  • ニボルマブによる薬剤性肺障害症例の検討

    柏田建, 齋藤好信, 峯岸裕司, 蛸井浩行, 渥美健一郎, 武内進, 松本優, 林宏紀, 野呂林太郎, 阿部信二, 藤田和恵, 清家正博, 吾妻安良太, 久保田馨, 弦間昭彦

    日本呼吸器学会学術講演会(第57回)  2017.4 

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    Venue:東京  

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  • 殺虫剤吸入後に発症した抗 MDA5 抗体陽性間質性肺炎の1例

    青山純, 林宏紀, 矢嶋知佳, 蛸井浩行, 柏田健, 渥美健一郎, 藤田和恵, 齋藤好信, 阿部信二, 吾妻安良太, 久保田馨, 弦間昭彦, 寺崎泰弘

    日本呼吸器学会関東地方会(第 223 回)  2017.2 

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  • 殺虫剤吸入後に発症した抗MDA5抗体陽性間質性肺炎の1例

    青山 純一, 林 宏紀, 矢嶋 知佳, 蛸井 浩行, 柏田 建, 渥美 健一郎, 藤田 和恵, 齋藤 好信, 阿部 信二, 吾妻 安良太, 久保田 馨, 弦間 昭彦, 國保 成暁, 功刀 しのぶ, 寺崎 泰弘

    日本呼吸器学会関東地方会(第223回)  2017.2 

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    Venue:東京  

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  • 活動性肺結核の治療中に急速に胸水貯留をきたし局所麻酔下胸腔鏡を施行した1例

    矢嶋知佳, 林宏紀, 蛸井浩行, 柏田建, 渥美健一郎, 藤田和恵, 齊藤好信, 阿部信二, 吾妻安良太, 久保田馨, 弦間昭彦

    日本結核病学会関東支部会(第170回)  2017.1 

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    Venue:山梨  

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  • Pseudoprogressionと判断されたNivolumabによる肺障害の1例

    須賀 実佑里, 峯岸 裕司, 高橋 彬彦, 高橋 聡, 渥美 健一郎, 久保田 馨, 弦間 昭彦

    日本肺癌学会 関東支部学術集会(第177回)  2016.11 

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    Venue:東京  

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  • 日本医科大学附属病院総合診療センターにおける感染症診療の実態に関する検討

    須﨑 真, 藤田 和恵, 渥美 健一郎, 林 宏紀, 小野寺 直子, 兵働 英也, 小原 俊彦, 斎藤 好信, 弦間 明彦, 安武 正弘

    日本感染症学会総会・学術講演会(第59回)  2016.11 

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    Venue:京都  

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  • 当院総合診療センターにおける感染症診療の現状と課題

    須﨑 真, 藤田 和恵, 渥美 健一郎, 林 宏紀, 小野寺 直子, 兵働 英也, 小原 俊彦, 宮内 雅人, 齋藤 好信, 弦間 昭彦, 安武 正弘

    日本感染症学会中日本地方会学術集会(第59回)  2016.11 

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    Venue:沖縄  

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  • 金属加工業者に発症し,DLST,HLA-DPB1アレルより診断した慢性ベリリウム肺の1例

    柏田 建, 阿部 信二, 蛸井 浩行, 渥美 健一郎, 林 宏紀, 藤田 和恵, 齋藤 好信, 弦間 昭彦, 久保田 馨, 國保 成暁, 寺崎 泰弘, 吾妻 安良太

    日本呼吸器学会関東地方会(第222回)  2016.11 

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    Venue:東京  

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  • 亜急性に進行したIgG4関連肺疾患の1例

    土屋 未央, 林 宏紀, 矢嶋 知佳, 蛸井 浩行, 柏田 建, 阿部 信二, 渥美 健一郎, 藤田 和恵, 齋藤 好信, 吾妻 安良太, 弦間 昭彦, 久保田 馨, 國保 成暁, 寺崎 泰弘

    日本呼吸器学会関東地方会(第222回)  2016.11 

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    Venue:東京  

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  • 活動性肺結核の治療中に急速に胸水貯留を来し局所麻酔下胸腔鏡を施行した1例

    矢嶋 知佳, 林 宏紀, 蛸井 浩行, 柏田 建, 渥美 健一郎, 藤田 和恵, 齋藤 好信, 阿部 信二, 吾妻 安良太, 久保田 馨, 弦間 昭彦

    日本呼吸器学会関東地方会(第221回)  2016.9 

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    Venue:山梨  

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  • 無気肺を呈したマイコプラズマ肺炎の検討

    佐藤 陽三, 藤田 和恵, 蛸井 浩行, 柏田 建, 國保 成暁, 渥美 健一郎, 林 宏紀, 齋藤 好信, 清家 正博, 久保田 馨, 弦間 昭彦

    日本呼吸器内視鏡学会学術集会(第39回)  2016.6 

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    Venue:名古屋  

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  • 当院における肺癌患者に対する再生検の実態調査

    高橋 明子, 清家 正博, 青山 純一, 小林 研一, 柏田 建, 渥美 健一郎, 林 宏紀, 野呂 林太郎, 峯岸 裕司, 藤田 和恵, 齋藤 好信, 久保田 馨, 弦間 昭彦

    日本呼吸器内視鏡学会学術集会(第39回)  2016.6 

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    Venue:名古屋  

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  • 金属加工業者に発症し,DLST,HLA-DPB1アレルより診断した慢性ベリリウム肺の1例

    柏田 建, 阿部 信二, 蛸井 浩行, 渥美 健一郎, 林 宏紀, 藤田 和恵, 齋藤 好信, 弦間 昭彦, 久保田 馨, 國保 成暁, 寺崎 泰弘, 吾妻 安良太

    東京サルコイドーシス/肉芽種性疾患研究会(第183回)  2016.6 

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  • Re-biopsy 当院における肺癌患者に対する再生検の実態調査

    高橋 明子, 清家 正博, 青山 純一, 小林 研一, 柏田 建, 渥美 健一郎, 林 宏紀, 野呂 林太郎, 峯岸 裕司, 藤田 和恵, 齋藤 好信, 久保田 馨, 弦間 昭彦

    日本呼吸器内視鏡学会学術集会(第39回)  2016.6 

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    Venue:名古屋  

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  • 金属加工業者に発症し,DLST,HLA-DPB1アレルより診断した慢性ベリリウム肺の1例

    柏田 建, 阿部 信二, 蛸井 浩行, 渥美 健一郎, 林 宏紀, 藤田 和恵, 齋藤 好信, 弦間 昭彦, 久保田 馨, 國保 成暁, 寺崎 泰弘, 吾妻 安良太

    東京サルコイドーシス/肉芽種性疾患研究会(第183回)  2016.6 

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    Venue:東京  

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  • 75才以上の進行期非小細胞肺がんに対するAfatinib使用成績

    内藤 智之, 水谷 英明, 高橋 彬彦, 佐藤 陽三, 高橋 明子, 渥美 健一郎, 竹内 進, 宮永 晃彦, 峰岸 裕司, 清家 正博, 久保田 馨, 弦間 昭彦

    日本呼吸器学会学術集会(第56回)  2016.4 

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    Venue:京都市  

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  • 当院における抗ARS抗体陽性間質性肺炎の臨床病理学的検討

    柏田 建, 根井 貴仁, 齋藤 好信, 中山 幸治, 渥美 健一郎, 林 宏紀, 藤田 和恵, 久保田 馨, 吾妻 安良太, 國保 成暁, 功刀 しのぶ, 寺崎 泰弘, 弦間 昭彦

    日本呼吸器学会学術講演会(第56回)  2016.4 

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  • 当院における抗ARS抗体陽性間質性肺炎の臨床病理学的検討

    柏田 建, 根井 貴仁, 齋藤 好信, 中山 幸治, 渥美 健一郎, 林 宏紀, 藤田 和恵, 久保田 馨, 吾妻 安良太, 國保 成暁, 功刀 しのぶ, 寺崎 泰弘, 弦間 昭彦

    日本呼吸器学会学術講演会(第56回)  2016.4 

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  • 初診時の抗ARS抗体陽性間質性肺炎における臨床的特徴について

    中山 幸治, 林 宏紀, 柏田 建, 齋藤 好信, 三山 江穂, 渥美 健一郎, 國保 成暁, 藤田 和恵, 吾妻 安良太, 久保田 馨, 弦間 昭彦

    日本呼吸器学会学術講演会(第56回)  2016.4 

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  • 75歳以上の進行期非小細胞肺がんに対するAfatinib使用成績

    内藤 智之, 水谷 英明, 高橋 彬彦, 佐藤 陽三, 高橋 明子, 渥美 健一郎, 武内 進, 宮永 晃彦, 峯岸 裕司, 清家 正博, 久保田 馨, 弦間 昭彦

    日本呼吸器学会学術講演会(第56回)  2016.4 

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    Venue:京都  

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  • 呼吸器疾患合併重症PHに対するPAH特異的治療薬の有効性

    渥美健一郎, 林宏紀, 田中徹, 蛸井浩行, 柏田建, 齋藤好信, 清家正博, 弦間昭彦, 福嶋善光, 久保田芳明, 木村弘

    日本肺高血圧・肺循環学会学術集会(第3回)  2018.6 

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    Venue:大阪  

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  • 当院におけるEBUS-TBNAの診断率と関連因子の検討

    渥美健一郎, 林宏紀, 鏑木翔太, 久金翔, 田中徹, 蛸井浩行, 柏田建, 國保成暁, 藤田和恵, 齋藤好信, 阿部信二, 木村弘, 久保田馨, 清家正博, 弦間昭彦

    日本呼吸器内視鏡学会学術集会(第41回)  2018.5 

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    Venue:東京  

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  • 当科におけるEBUS-GSでの診断率に関する検討

    戸塚猛大, 鏑木翔太, 北川真吾, 高野賢治, 高橋彬彦, 高野夏希, 久金翔, 高橋聡, 蛸井浩行, 田中徹, 柏田建, 菅野哲平, 渥美健一郎, 武内進, 林宏紀, 峯岸裕司, 野呂林太郎, 齋藤好信, 久保田馨, 清家正博, 弦間昭彦

    日本呼吸器内視鏡学会学術集会(第41回)  2018.5 

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  • 非小細胞肺癌へ対するnab-Paclitaxel療法による薬剤性肺障害の検討

    柏田建, 齋藤好信, 高橋聡, 小林研一, 渥美健一郎, 菅野哲平, 武内進, 林宏紀, 野呂林太郎, 峯岸裕司, 藤田和恵, 阿部信二, 清家正博, 久保田馨, 弦間昭彦

    日本呼吸器学会学術講演会(第58回)  2018.4 

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    Venue:大阪  

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  • エクソソーム由来microRNAの肺線維化マーカー抑制効果に関する検討

    猪俣稔, 神尾孝一郎, 吾妻安良太, 松田久仁子, 柏田建, 國保成暁, 渥美健一郎, 林宏紀, 藤田和恵, 齋藤好信, 阿部信二, 弦間昭彦

    日本呼吸器学会学術講演会(第58回)  2018.4 

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    Venue:大阪  

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  • 過粘稠性肺炎桿菌による重症肺炎・肺膿瘍の2例

    鏑木翔太, 蛸井浩行, 田中徹, 柏田建, 渥美健一郎, 林宏紀, 藤田和恵, 齋藤好信, 阿部信二, 清家正博, 弦間昭彦, 木村弘, 國保成暁, 寺崎泰弘

    日本呼吸器学会関東地方会(第228回)  2018.2 

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    Venue:東京  

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  • 殺虫剤吸入後に発症した抗MDA5抗体陽性間質性肺炎の1例

    青山純一, 林宏紀, 矢嶋知佳, 蛸井浩行, 柏田健, 渥美健一郎, 藤田和恵, 齋藤好信, 阿部信二, 吾妻安良太, 久保田馨, 弦間昭彦

    日本呼吸器学会関東地方会(第223回)  2018.2 

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  • 金属加工業者に発症し,DLST,HLA-DPB1アレルより診断した慢性ベリリウム肺の1例

    柏田建, 阿部信二, 蛸井浩行, 渥美健一郎, 林宏紀, 藤田和恵, 斎藤好信, 弦間昭彦, 久保田馨, 國保成暁, 寺崎泰弘, 吾妻安良太

    東京サルコイドーシス/肉芽種性疾患研究会(第186回)  2017.12 

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    Venue:東京  

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  • HIV感染に合併したAFOP(Acute fibrinous and organizing pneumonia)様の間質性肺炎の1例

    高野賢治, 田中徹, 渥美健一郎, 林宏紀, 齋藤好信, 阿部信二, 久保田馨, 弦間昭彦, 木村弘, 國保成暁, 寺崎泰弘

    日本呼吸器学会 関東地方会(第227回)  2017.11 

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    Venue:東京  

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  • HIV感染に合併したAFOP(Acute fibrinous and organizing pneumonia)様の間質性肺炎の1例

    高野賢治, 田中徹, 渥美健一郎, 林宏紀, 齋藤好信, 阿部信二, 久保田馨, 弦間昭彦, 木村弘, 國保成暁, 寺崎泰弘

    日本呼吸器学会 関東地方会(第227回)  2017.11 

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  • HIV感染に合併したAFOP(Acute fibrinous and organizing pneumonia)様の間質性肺炎の1例

    高野賢治, 田中徹, 渥美健一郎, 林宏紀, 齋藤好信, 阿部信二, 久保田馨, 弦間昭彦, 木村弘, 國保成暁, 寺崎泰弘

    日本呼吸器学会 関東地方会(第227回)  2017.11 

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  • 金属加工業者に発症し,DLST,HLA-DPB1アレルより診断した慢性ベリリウム肺の1例

    柏田建, 阿部信二, 蛸井浩行, 渥美健一郎, 林宏紀, 藤田和恵, 斎藤好信, 弦間昭彦, 久保田馨, 國保成暁, 寺崎泰弘, 吾妻安良太

    東京サルコイドーシス/肉芽種性疾患研究会(第186回)  2017.10 

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    Venue:東京  

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  • 特発性肺線維症に合併した重度肺高血圧症に対してsildenafilとmacitentanを併用した1例

    田中徹, 高野賢治, 渥美健一郎, 林宏紀, 齋藤好信, 阿部信二, 久保田馨, 弦間昭彦, 木村弘

    日本呼吸器学会関東地方会(第226回)  2017.9 

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    Venue:茨城  

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  • 指端壊死と急速進行性間質性肺炎をきたした腫瘍関連 amyopathic dermatomyositis の一剖検例

    高野賢治, 田中徹, 渥美健一郎, 林宏紀, 齋藤好信, 阿部信二, 弦間昭彦, 久保田馨, 寺崎泰弘, 福栄亮介, 桑名正隆

    日本呼吸器学会関東地方会(第 225 回)  2017.7 

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  • 指端壊死と急速進行性間質性肺炎をきたした腫瘍関連amyopathic dermatomyositisの一剖検例

    高野賢治, 田中徹, 渥美健一郎, 林宏紀, 齋藤好信, 阿部信二, 久保田馨, 弦間昭彦, 寺崎泰弘, 福栄亮介, 桑名正隆

    日本呼吸器学会関東地方会(第225回)  2017.7 

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    Venue:東京  

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  • 指端壊死と急速進行性間質性肺炎をきたした腫瘍関連 amyopathic dermatomyositisの1剖検例

    高野賢治, 田中徹, 渥美健一郎, 林宏紀, 齋藤好信, 阿部信二, 弦間昭彦, 久保田馨, 寺崎泰弘, 福栄亮介, 桑名正隆

    日本呼吸器学会関東地方会(第225回)  2017.7 

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  • EBUS-TBNA後に生じた縦隔炎の2症例

    高橋聡, 渥美健一郎, 樋口明日香, 矢嶋知佳, 中山幸治, 蓮見健太, 青山純一, 久世眞之, 小林研一, 蛸井浩行, 吉川明子, 柏田建, 揖斐孝之, 武内進, 井上達哉

    日本呼吸器内視鏡学会学術集会(第40回)  2017.6 

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    Venue:長崎  

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  • EBUS-TBNA後に生じた縦隔炎の2症例

    高橋聡, 渥美健一郎, 樋口明日香, 矢嶋知佳, 中山幸治, 蓮見健太, 青山純一, 久世眞之, 小林研一, 蛸井浩行, 吉川明子, 柏田建, 揖斐孝之, 武内進, 井上達哉

    日本呼吸器内視鏡学会学術集会(第40回)  2017.6 

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    Venue:長崎  

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  • 脊椎疾患による呼吸不全が疑われた3例

    蛸井浩行, 青山純一, 渥美健一郎, 林宏紀, 藤田和恵, 齋藤好信, 阿部信二, 久保田馨, 弦間昭彦

    日本呼吸器学会関東地方会(第224回)  2017.5 

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    Venue:東京  

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  • 健常者に発症した気道侵襲性肺アスペルギルス症の1例

    渥美健一郎, 林宏紀, 青山純一, 田中徹, 蛸井浩行, 柏田建, 藤田和恵, 齋藤好信, 阿部信二, 吾妻安良太, 久保田馨, 弦間昭彦, 國保成暁, 功刀功刀, 寺崎泰弘

    日本呼吸器学会関東地方会(第 224 回)  2017.5 

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  • 健常者に発症した気道侵襲性肺アスペルギルス症の1例

    渥美健一郎, 林宏紀, 青山純一, 田中徹, 蛸井浩行, 柏田建, 藤田和恵, 齋藤好信, 阿部信二, 吾妻安良太, 久保田馨, 弦間昭彦, 國保成暁, 功刀功刀, 寺崎泰弘

    日本呼吸器学会関東地方会(第 224 回)  2017.5 

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  • 健常者に発症した気道侵襲性肺アスペルギルス症の1例

    渥美健一郎, 林宏紀, 青山純一, 田中徹, 蛸井浩行, 柏田建, 藤田和恵, 齋藤好信, 阿部信二, 吾妻安良太, 久保田馨, 弦間昭彦, 國保成暁, 功刀しのぶ, 寺崎泰弘

    日本呼吸器学会関東地方会(第224回)  2017.5 

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    Venue:東京  

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  • 関節リウマチに対するMTXの内服中止に伴ってサルコイドーシスが顕在化した1例

    宮下稜太, 林宏紀, 鈴木彩奈, 戸塚猛大, 渥美健一郎, 齋藤好信, 木村弘, 清家正博, 弦間昭彦, 寺崎泰弘

    日本内科学会関東地方会(第646回)  2018.11 

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    Venue:東京  

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  • 肺の多発結節影を認め、レミエール症候群と診断した2例

    芳賀三四郎, 林宏紀, 宮下稜太, 鈴木彩奈, 戸塚猛大, 渥美健一郎, 齋藤好信, 清家正博, 弦間昭彦, 木村弘

    日本内科学会関東地方会(第646回)  2018.11 

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    Venue:東京  

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  • 肺換気血流SPECT/CTによる3群PHの治療適応症例の追求と評価

    渥美健一郎, 林宏紀, 二島駿一, 田中徹, 柏田建, 齋藤好信, 清家正博, 弦間昭彦, 久保田芳明, 福嶋善光, 木村弘

    日本肺高血圧・肺循環学会学術集会(第4回)  2019.6 

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    Venue:浜松  

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  • インフルエンザおよび黄色ブドウ球菌重複感染による気管支肺炎に,脳梁膨大部病変を伴う脳症を併発した1例

    櫻井侑美, 田中徹, 二島駿一, 武内進, 柏田建, 渥美健一郎, 林宏紀, 藤田和恵, 齋藤好信, 木村弘, 久保田馨, 清家正博, 弦間昭彦

    日本呼吸器学会関東地方会(第234回)  2019.5 

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    Venue:東京  

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  • 収縮性心膜炎を合併し心膜切除術を施行した結核性心膜炎の一例

    岡村賢, 林宏紀, 須賀実佑里, 戸塚猛大, 北川真吾, 田中徹, 柏田建, 渥美健一郎, 藤田和恵, 齋藤好信, 功刀しのぶ, 寺崎泰弘, 石原翔, 廣本敦之, 清家正博, 久保田馨, 木村弘, 弦間昭彦

    日本呼吸器学会関東地方会(第234回)  2019.5 

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    Venue:東京  

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  • 肺疾患に伴う肺高血圧症に対する肺換気血流SPECT/CTによる治療評価

    渥美健一郎, 林宏紀, 二島駿一, 田中徹, 蛸井浩行, 柏田建, 藤田和恵, 齋藤好信, 清家正博, 弦間昭彦, 久保田芳明, 福嶋善光, 木村弘

    日本呼吸器学会学術講演会(第59回)  2019.4 

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    Venue:東京  

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  • 特発性肺線維症急性増悪例の分類改定案の自験例による検証

    柏田建, 齋藤好信, 渥美健一郎, 戸塚猛大, 田中徹, 林宏紀, 神尾孝一郎, 藤田和恵, 木村弘, 久保田馨, 吾妻安良太, 清家正博, 弦間昭彦

    日本呼吸器学会学術講演会(第59回)  2019.4 

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    Venue:東京  

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  • 肺血管拡張薬の有効性を認めた慢性閉塞性肺疾患に伴う肺高血圧症の一例

    鈴木彩奈, 渥美健一郎, 戸塚猛大, 二島駿一, 田中徹, 柏田建, 林宏紀, 藤田和恵, 齋藤好信, 清家正博, 弦間昭彦, 木村弘

    日本呼吸器学会関東地方会(第232回)  2018.11 

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    Venue:東京  

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  • Novel evaluation of pulmonary hypertension with chronic lung disease by perfusion SPECT/CT International conference

    Kenichiro Atsumi, Hiroki Hayashi, Shunichi Nishima, Toru Tanaka, Takeru Kashiwada, Yoshinobu Saito, Masahiro Seike, Akihiko Gemma, Yoshiaki Kubota, Yoshimitsu Fukushima, Hiroshi Kimura

    European Respiratory Society (ERS)  2019.9 

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    Venue:Madrid  

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  • 早期治療介入するも難治性末梢神経障害と大腸潰瘍を来したEGPAの1例

    千田絵里佳, 渥美健一郎, 林杏奈, 清水理光, 二島駿一, 田中徹, 柏田建, 林宏紀, 藤田和恵, 寺崎泰弘, 櫻井侑美, 谷口泰之, 齋藤好信, 木村弘, 清家正博, 弦間昭彦

    日本呼吸器学会関東地方会(第236回)  2019.9 

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    Venue:東京  

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  • EBUS-TBNA後に気管支内穿破,内腔にポリープ状の隆起性病変を来たした結核性リンパ節炎の1例

    久金翔, 藤田和恵, 菅野哲平, 髙野夏希, 二島駿一, 髙橋聡, 田中徹, 柏田建, 渥美健一郎, 武内進, 宮永晃彦, 林宏紀, 齋藤好信, 久保田馨, 木村弘, 清家正博, 弦間昭彦

    日本呼吸器内視鏡学会学術集会(第42回)  2019.7 

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    Venue:東京  

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  • 当院における気管支サーモプラスティの使用経験

    北川真吾, 林宏紀, 髙野夏希, 二島駿一, 久金翔, 髙橋聡, 田中徹, 柏田建, 菅野哲平, 渥美健一郎, 藤田和恵, 齋藤好信, 木村弘, 久保田馨, 清家正博, 弦間昭彦

    日本呼吸器内視鏡学会学術集会(第42回)  2019.7 

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    Venue:東京  

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  • 当院における肺原発 MALT lymphoma 二切除例の検討

    竹ヶ原 京志郎, 鳥山 紗由子, 佐藤 明, 揖斐 孝之, 井上 達哉, 石角 太一郎, 渥美 健一郎, 森本 泰介, 弦間 昭彦, 臼田 実男

    日本肺癌学会学術集会(第56回)  2015.11 

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    Venue:神奈川県横浜市  

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  • 肺扁平上皮癌に対するペンブロリズマブ投与中に発症した耳介軟骨炎の1例

    寺嶋勇人, 渥美健一郎, 寺師直樹, 鈴木彩奈, 久金翔, 岩田隆, 細谷慶, 永田耕治, 廣瀬敬

    日本内科学会 関東地方会(第676回)  2022.3 

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  • Efficacy of repeat re-biopsy and osimertinib in patients with EGFR mutation positive advanced NSCLC International conference

    Takashi Hirose, Kenichiro Atsumi, Hiroki Kato, Keiki Miyadera, Sho Hisagane, Kaoru Kubota, Masahiro Seike, Akihiko Gemma

    The 25th Congress of APSR  2021.11 

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  • Analysis of %FVC/%DLco ratio for pulmonary hypertension associated with interstitial lung disease International conference

    Kenichiro Atsumi, Yosuke Tanaka, Kakeru Hisakane, Toru Tanaka, Takeru Kashiwada, Yoshinobu Saito, Kazue Fujita, Takashi Hirose, Masahiro Seike, Arata Azuma, Hiroshi Kimura, Akihiko Gemma

    The 25th Congress of APSR  2021.11 

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  • 黒色胸水を契機に診断された膵胸腔瘻の1 例

    宮寺恵希, 久金翔, 加藤祐樹, 渥美健一郎, 大野弘貴, 田中周, 久保田馨, 清家正博, 弦間昭彦, 廣瀬敬

    日本呼吸器学会関東地方会(第246回)  2021.9 

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  • 気管支肺胞洗浄液の塗抹陰性後に喀痰塗抹陽性となった肺結核の1例

    加藤祐樹, 渥美健一郎, 宮寺恵希, 久金翔, 清家正博, 弦間昭彦, 廣瀬敬

    日本呼吸器学会関東地方会(第245回)  2021.7 

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  • 自家骨髄細胞による肺線維症モデルマウスの病態改善効果に関する研究

    神尾孝一郎, 吾妻安良太, 松田久仁子, 猪俣稔, 久世眞之, 臼杵二郎, 田中徹, 柏田建, 佐藤純平, 西島伸彦, 渥美健一郎, 齋藤好信, 清家正博, 弦間昭彦

    日本呼吸器学会学術講演会(第61回)  2021.4 

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  • 間質性肺炎に伴う肺高血圧症に対する%FVC/%DLcoの有用性の検討

    渥美健一郎, 田中徹, 柏田建, 田中庸介, 齋藤好信, 藤田和恵, 廣瀬敬, 清家正博, 吾妻安良太, 木村弘, 弦間昭彦

    日本呼吸器学会学術講演会(第61回)  2021.4 

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  • 免疫チェックポイント阻害薬投与後に発症した,免疫関連有害事象による副腎機能低下症の3例

    宮下稜太, 中山幸治, 齊藤翔, 渥美健一郎, 久保田馨, 清家正博, 弦間昭彦, 廣瀬敬

    日本呼吸器学会関東地方会(第243回)  2021.3 

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  • Atezolizumab併用化学療法中にANCA関連血管炎を発症した一例

    齊藤翔, 中山幸治, 宮下稜太, 渥美健一郎, 中里玲, 金子朋広, 永田耕治, 清水章, 久保田馨, 清家正博, 弦間昭彦, 廣瀬敬

    日本呼吸器学会関東地方会(第243回)  2021.2 

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  • Nivolumab+Ipilimumab投与中に胸膜炎症状のPseudoprogressionを呈した胸膜播種を伴う肺癌の一例

    寺嶋勇人, 渥美健一郎, 寺師直樹, 鈴木彩奈, 久金翔, 永田耕治, 清家正博, 弦間昭彦, 廣瀬敬

    日本肺癌学会 関東支部学術集会(第192回)  2022.3 

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  • デュルバルマブ投与後に激症1型糖尿病を発症した小細胞肺癌の一例

    寺師直樹, 久金翔, 宮寺恵希, 寺嶋勇人, 鈴木彩奈, 渥美健一郎, 清家正博, 弦間昭彦, 廣瀬敬

    日本肺癌学会 関東支部学術集会(第191回)  2021.12 

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  • 肺癌合併特発性肺線維症の急性増悪例における分類改定案を用いた予後の検討

    柏田建, 齋藤好信, 渥美健一郎, 大森美和子, 二島駿一, 田中徹, 神尾孝一郎, 田中庸介, 木村弘, 吾妻安良太, 清家正博, 弦間昭彦

    日本呼吸器学会学術講演会(第60回)  2020.9 

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  • 気管支肺胞洗浄液を用いたPCR検査により診断に至ったインフルエンザ肺炎の4例

    芳賀三四郎, 田中徹, 湯浅瑞希, 清水理光, 二島駿一, 柏田建, 渥美健一郎, 田中庸介, 齋藤好信, 藤田和恵, 木村弘, 久保田馨, 清家正博, 弦間昭彦

    日本呼吸器内視鏡学会学術集会(第43回)  2020.6 

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  • 当院における肺非結核性抗酸菌症診断に対する気管支鏡検査の有用性

    宮寺恵希, 湯浅瑞希, 清水理光, 二島駿一, 田中徹, 柏田建, 渥美健一郎, 田中庸介, 齋藤好信, 藤田和恵, 木村弘, 久保田馨, 清家正博, 弦間昭彦

    日本呼吸器内視鏡学会学術集会(第43回)  2020.6 

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  • EGFR-TKIによる薬剤性肺障害に対して気管支鏡にて肺胞出血と診断した3症例

    千田絵里佳, 清水理光, 湯浅瑞希, 二島駿一, 恩田直美, 田中徹, 柏田建, 中道真仁, 菅野哲平, 渥美健一郎, 峯岸裕司, 野呂林太郎, 田中庸介, 齋藤好信, 木村弘, 久保田馨, 清家正博, 弦間昭彦

    日本呼吸器内視鏡学会学術集会(第43回)  2020.6 

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  • HIV-PCPの治療中にCMV感染症を発症した一例

    松木覚, 渥美健一郎, 芳賀三四郎, 湯浅瑞希, 清水理光, 二島駿一, 田中徹, 柏田建, 田中庸介, 齋藤好信, 藤田和恵, 木村弘, 清家正博, 弦間昭彦

    日本呼吸器学会関東地方会(第238回)  2020.2 

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    Venue:東京  

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  • 気管支鏡にて診断した汎血球減少改善に伴い発症したメトトレキサート肺炎の1例

    芳賀三四郎, 田中徹, 湯浅瑞希, 清水理光, 二島駿一, 柏田建, 渥美健一郎, 田中庸介, 齋藤好信, 寺崎泰弘, 木村弘, 久保田馨, 清家正博, 弦間昭彦

    日本呼吸器内視鏡学会関東支部会(第171回)  2019.12 

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    Venue:東京  

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  • 抗ARS抗体症候群に過敏性肺炎が合併した1例

    宮下稜太, 二島駿一, 柏田建, 宮寺恵希, 清水理光, 田中徹, 中道真仁, 渥美健一郎, 林宏紀, 藤田和恵, 齊藤好信, 功刀しのぶ, 木村弘, 清家正博, 弦間昭彦

    日本呼吸器学会関東地方会(第237回)  2019.11 

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  • 特発性肺線維症における抗線維化薬治療中に発症した間質性肺炎急性増悪の予後

    二島駿一, 齋藤好信, 湯浅瑞希, 清水理光, 田中徹, 柏田建, 渥美健一郎, 神尾孝一郎, 田中庸介, 藤田和恵, 木村弘, 吾妻安良太, 清家正博, 弦間昭彦

    日本呼吸器学会学術講演会(第60回)  2020.9 

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  • 血清エクソソーム由来microRNAによる肺線維芽細胞から筋線維芽細胞への分化調節機構の検討

    久世眞之, 神尾孝一郎, 吾妻安良太, 松田久仁子, 猪俣稔, 田中徹, 柏田建, 渥美健一郎, 齋藤好信, 清家正博, 弦間昭彦

    日本呼吸器学会学術講演会(第60回)  2020.9 

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  • 光電式容積脈波センサによる間質性肺疾患の動肺コンプライアンス測定の有用性

    渥美健一郎, 齋藤好信, 湯浅瑞希, 清水理光, 二島駿一, 田中徹, 柏田建, 林宏紀, 田中庸介, 藤田和恵, 木村弘, 清家正博, 大崎理江, 酒井一泰, 黒澤慎也, 弦間昭彦, 吾妻安良太

    日本呼吸器学会学術講演会(第60回)  2020.9 

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  • MPO-ANCA陽性肺病変の臨床的検討

    二島 駿一, 林 宏紀, 田中 徹, 渥美 健一郎, 三浦 由記子, 國保 成暁, 藤田 和恵, 齋藤 好信, 吾妻 安良太, 弦間 昭彦

    日本呼吸器学会総会学術講演会(第54回)  2014.4 

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  • 当院における特発性肺線維症の急性増悪の予後関連因子の検討

    渥美 健一郎, 齋藤 好信, 三浦 由記子, 國保 成暁, 田中 徹, 林 宏紀, 藤田 和恵, 吾妻 安良太, 弦間 昭彦

    日本呼吸器学会総会学術講演会(第54回)  2014.4 

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  • 間質性肺炎におけるGallium SPECT-CT検査の有用性

    林 宏紀, 齋藤 好信, 田中 徹, 猪俣 稔, 渥美 健一郎, 三浦 由記子, 國保 成暁, 藤田 和恵, 吾妻 安良太, 弦間 昭彦, 福嶋 善光

    日本呼吸器学会誌  2014.3 

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  • MPO-ANCA陽性肺病変の臨床的検討

    二島 駿一, 林 宏紀, 田中 徹, 渥美 健一郎, 三浦 由記子, 國保 成暁, 藤田 和恵, 齋藤 好信, 吾妻 安良太, 弦間 昭彦

    日本呼吸器学会誌  2014.3 

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  • 当院における特発性肺線維症の急性増悪の予後関連因子の検討

    渥美 健一郎, 齋藤 好信, 三浦 由記子, 國保 成暁, 田中 徹, 林 宏紀, 藤田 和恵, 吾妻 安良太, 弦間 昭彦

    日本呼吸器学会誌  2014.3 

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  • Longer delays in diagnosis of tuberculosis in a tokyo metropolitan area International conference

    Kazue Fujita, Kazuhiro Kitamura, Kosuke Narita, Kenichiro Atsumi, Yukiko Miura, Hiroki Hayashi, Yoshinobu Saito, Arata Azuma, Akihiko Gemma

    APSR  2013.11 

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    Venue:Yokohama  

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  • 続発性気胸により見された多肺嚢胞と間質炎を合併し若年女の1例

    渥美 健一郎, 高野 夏希, 佐藤 陽三, 峰岸 裕司, 齋藤 好信, 弦間 昭彦, 寺崎 泰弘, 高橋 美紀子, 漆山 博和, 功刀 しのぶ

    呼吸器病理研究会(第43回)  2013.7 

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  • 胸部放射線療法3年後にCrizotinibを投与し,2週間で食道潰瘍が出現した肺腺癌の1例

    高野 夏希, 渥美 健一郎, 大森 美和子, 峯岸 裕司, 弦間 昭彦

    日本肺癌学会関東支部会(第167回)  2013.6 

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    Venue:東京  

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  • Evaluation of Diagnostic Performance in Patients Who Underwent Bronchoscopy in Our Hospital for Diagnosis of Sarcoidosis International conference

    Kenichiro Atsumi, Yousuke Tanaka, Mitsunori Hino

    APSR  2012.12 

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    Venue:Hong Kong  

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  • Study of pulmonary thromboembolism (PTE) in patients with lung cancer International conference

    Kenichiro Atsumi, Yosuke Tanaka, Mitsunori Hino

    APSR  2011.11 

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    Venue:Shanghai  

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  • ゲフィチニブ投与中にネフローゼ症候群を呈した1例

    小林 由美子, 武内 進, 青山 純一, 加藤 泰裕, 小林 有紀, 佐藤 陽三, 清水 理光, 高野 夏希, 中鉢 久美, 中道 真仁, 渥美 健一郎, 宮永 晃彦, 山本 和男, 藤田 和恵, 峯岸 裕司

    日本肺癌学会関東支部会(第169回)  2014.3 

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    Venue:東京  

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  • 高齢者の進行非小細胞肺癌に対するCarboplatin+weekly Paclitaxel併用化学療法についての検討

    渥美 健一郎, 山名 一平, 豊川 優, 安藤 真弘, 弦間 昭彦, 工藤 翔二

    日本呼吸器学会学術講演会(第47回)  2007.5 

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  • 緊張性気胸様変化を呈した肺気腫・巨大肺嚢胞の1例

    根井貴仁, 茂木孝, 重盛朋子, 渥美健一郎, 武内進, 斉藤好信, 篠田欣也, 工藤翔二, 中山智子

    The lung perspective  2005 

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  • 多発結節影を呈し胸腔鏡下生検にて診断した肺MALT Lymphomaの1例

    渥美健一郎, 日野光紀, 上鶴里央子, 楢戸律子, 上原隆志, 小俣雅稔, 田中庸介, 小野靖, 吉野直之, 大秋美治

    日本医科大学医学会第112回例会  2004.2 

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  • 多発結節影を呈し胸腔鏡下生検にて診断した肺MALT Lymphomaの1例

    渥美健一郎, 日野光紀, 上鶴里央子, 楢戸律子, 上原隆志, 小俣雅稔, 田中庸介, 小野靖, 吉野直之, 大秋美治

    日本医科大学医学会第112回例会  2004.2 

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  • カルボプラチン+パクリタキセル+ニボルマブ+イピリムマブ併用療法が奏効した肺原発絨毛癌の一例

    磯博和, 久金翔, 三上恵莉花, 松木覚, 渥美健一郎, 永田耕治, 吉野直之, 清家正博, 弦間昭彦, 廣瀬敬

    日本肺癌学会 関東支部学術集会(第193回)  2022.7 

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  • COVID-19感染の回復期における白血球像の分析

    渥美健一郎, 久金翔, 鈴木彩奈, 清家正博, 弦間昭彦, 廣瀬敬

    日本呼吸器学会学術講演会(第62回)  2022.4 

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  • 非小細胞肺癌におけるイレッサ不応例に対する後治療の検討

    山名一平, 安藤真弘, 北村和広, 渥美健一郎, 工藤翔二

    日本呼吸器学会学術講演会(第46回)  2006.6 

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  • 成人T細胞性白血病(ATL)に合併した難治性気道病変の一剖検例

    武内進, 渥美健一郎, 根井貴仁, 齋藤好信, 阿部信二, 臼杵二郎, 吾妻安良太, 工藤翔二

    第169回日本呼吸器学会関東地方会  2006.5 

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  • 2次化学療法としてカルボプラチン+パクリタキセルが有効であった特発性間質性肺炎合併小細胞癌の1例

    中山 幸治, 峯岸 裕司, 小林 研一, 渥美 健一郎, 清家 正博, 久保田 馨, 弦間 昭彦

    日本肺癌学会関東支部会(第175回)  2016.3 

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    Venue:東京都  

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  • 当院における抗ARS抗体陽性間質性肺炎の臨床病理学的検討

    柏田 建, 根井 貴仁, 齋藤 好信, 中山 幸治, 渥美 健一郎, 林 宏紀, 藤田 和恵, 久保田 馨, 吾妻 安良太, 國保 成暁, 功刀 しのぶ, 寺崎 泰弘, 弦間 昭彦

    日本呼吸器学会誌  2016.3 

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  • 初診時の抗ARS抗体陽性間質性肺炎における臨床的特徴について

    中山 幸治, 林 宏紀, 柏田 建, 齋藤 好信, 三山 江穂, 渥美 健一郎, 國保 成暁, 藤田 和恵, 吾妻 安良太, 久保田 馨, 弦間 昭彦

    日本呼吸器学会誌  2016.3 

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  • 75歳以上EGFR遺伝子変異陽性患者に対するAfatinibの使用成績

    水谷 英明, 峯岸 裕司, 高橋 彬彦, 佐藤 陽三, 渥美 健一郎, 高橋 明子, 武内 進, 宮永 晃彦, 清家 正博, 久保田 馨, 弦間 昭彦

    日本肺癌学会学術集会(第56回)  2015.11 

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    Venue:横浜  

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  • 当院における癌性胸膜炎に対する滅菌調整タルクとOK-432による胸膜癒着術の後方視的検討

    小林 研一, 清家 正博, 佐藤 陽三, 高橋 明子, 渥美 健一郎, 武内 進, 宮永 晃彦, 水谷 英明, 峯岸 裕司, 山本 和男, 久保田 馨, 弦間 昭彦

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    Language:Japanese  

    Venue:横浜  

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    Language:Japanese  

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    日本肺癌学会学術集会(第56回)  2015.11 

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    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:横浜  

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    日本肺癌学会学術集会(第56回)  2015.11 

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    Language:Japanese  

    Venue:横浜  

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