記述言語：英語   掲載種別：研究論文（学術雑誌）  

BACKGROUND AND AIM: Gastric atrophy is a precancerous lesion. We aimed to clarify whether gastric atrophy determined by artificial intelligence (AI) correlates with the diagnosis made by expert endoscopists using several endoscopic classifications, the Operative Link on Gastritis Assessment (OLGA) classification based on histological findings, and genotypes associated with gastric atrophy and cancer. METHODS: Two hundred seventy Helicobacter pylori-positive outpatients were enrolled. All patients' endoscopy data were retrospectively evaluated based on the Kimura-Takemoto, modified Kyoto, and OLGA classifications. The AI-trained neural network generated a continuous number between 0 and 1 for gastric atrophy. Nucleotide variance of some candidate genes was confirmed or selectively assessed for a variety of genotypes, including the COX-21195, IL-1β 511, and mPGES-1 genotypes. RESULTS: There were significant correlations between determinations of gastric atrophy by AI and by expert endoscopists using not only the Kimura-Takemoto classification (P < 0.001), but also the modified Kyoto classification (P = 0.046 and P < 0.001 for the two criteria). Moreover, there was a significant correlation with the OLGA classification (P = 0.009). Nucleotide variance of the COX-2, IL-1β, and mPGES-1genes was not significantly associated with gastric atrophy determined by AI. The area under the curve values of the combinations of AI and the modified Kyoto classification (0.746) and AI and the OLGA classification (0.675) were higher than in AI alone (0.665). CONCLUSION: Combinations of AI and the modified Kyoto classification or of AI and the OLGA classification could be useful tools for evaluating gastric atrophy in patients with H. pylori infection as the risk of gastric cancer.

DOI： 10.1002/jgh3.12810

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

BACKGROUND AND AIM: To clarify whether there were any significant differences in clinical symptoms and eating patterns between functional dyspepsia (FD) patients and FD with pancreatic enzyme abnormalities (FD-P) patients as refractory FD, we compared these factors in multicenter studies in Singapore and Japan. METHODS: One hundred ninety-eight consecutive patients presenting with FD (n = 88), FD-P patients (n = 81) based on Rome III classification and controlled group (n = 39) recruited from six institutions in Singapore and Japan. Clinical characteristics, clinical symptoms for dietary fat intake, and eating behaviors were estimated using questionnaires. Anxiety and health-related quality of life were determined by STAI-state/-trait and SF-8, respectively. RESULTS: There were no significant differences in age, sex, BMI, smoking, alcohol intake, past medical history, and history of allergy in FD and FD-P patients between Singapore and Japan. There were no significant differences in FD subtypes, gastrointestinal symptom rating scale score, severity of FD symptoms, and eating pattern in Singapore and Japan. Moreover, there were significant differences in certain eating behaviors between FD and FD-P patients in Singapore and Japan. Interestingly, epigastric pain and early satiety following fat meals in FD-P patients were significantly (P = 0.003 and P = 0.008, respectively) higher compared with those in FD patients in Japan. Physical component score in FD-P patients was significantly (P = 0.019) disturbed compared with those in FD patients in Japan. CONCLUSIONS: Epigastric pain and early satiety following fat meals in FD-P patients may be useful tools to differentiate FD-P patients from FD patients in Japan.

DOI： 10.1111/jgh.15874

PubMed

researchmap

記述言語：日本語   出版者・発行元：(株)先端医学社  

今まで、機能性ディスペプシア(FD)を考えるうえではHelicobacter pylori(H.pylori)感染の存在は曖昧であった。FDにおいてH.pylori陽性とH.pylori陰性に違いがあるのか?という疑問は、ここ数年の議論の結果、H.pylori関連ディスペプシア(HpD)とFDを明確に区別することで決着がついてきた。H.pylori感染は、内視鏡検査で認める萎縮性変化、腸上皮化生などの明らかな器質的変化を引き起こす。そのため、HpDは器質的疾患として考えるようになったわけである。今後はFD診療をおこなう際に、H.pylori未感染または除菌後のH.pylori陰性FD患者を対象とすることになるであろう。(著者抄録)

researchmap

記述言語：日本語   出版者・発行元：(株)東京医学社  

researchmap

その他リンク： https://search.jamas.or.jp/default/link?pub_year=2022&ichushi_jid=J02312&link_issn=&doc_id=20220511060022&doc_link_id=%2Faq9syokd%2F2022%2F003404%2F023%2F0621-0624%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Faq9syokd%2F2022%2F003404%2F023%2F0621-0624%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

記述言語：日本語   出版者・発行元：(株)南山堂  

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

We have reported that refractory functional dyspepsia patients with pancreatic enzyme abnormalities (FD-P). We tried to analyze the prevalence of exocrine pancreatic insufficiency (EPI) in FD-P patients to clarify whether the pathophysiology of FD patients including clinical symptoms and quality of life were associated with EPI. We enrolled forty-nine patients presenting with typical symptoms of FD-P patients (n = 20) and asymptomatic patients with pancreatic enzyme abnormalities (AP-P) (n = 29). Five pancreatic enzymes (p-amylase, lipase, elastase-1, trypsin, and PLA2) were measured and STAI-state/-trait and SF-8 were evaluated. Pancreatic exocrine function was analyzed using N-benzoyl-l-tyrosyl-p-aminobenzoic acid (BT-PABA). There were no significant differences in patient background between FD-P and AP-P patients. BT-PABA test scores for FD-P patients (61.67 ± 5.55) were significantly (p = 0.01) lower than in AP-P patients (95.38 ± 2.36). Physical component scale (PCS) in FD-P patients was significantly (p = 0.002) lower than that in AP-P patients. STAI-state was relatively (p = 0.054) associated with BT-PABA test in FD-P and AP-P patients by multiple logistic regression analysis. The prevalence of EPI in FD-P patients was significantly higher than that in AP-P patients and was relatively associated with state of anxiety. Further studies will be needed to clarify how EPI or pancreatic enzyme abnormalities are associated with the pathophysiology of FD-P patients.

DOI： 10.3164/jcbn.21-67

PubMed

researchmap

記述言語：日本語   出版者・発行元：(株)診断と治療社  

＜Headline＞1 刺激性下剤は浸透圧性下剤の1つである、酸化マグネシウムによる慢性便秘症に対する治療が治療の大部分を占めているとされている。刺激性下剤による治療を適正に行うことが重要である。2 刺激性下剤による強い排便作用は、消化管の大蠕動を誘発する作用によるものであり、排便における爽快感などが生じる。3 「慢性便秘症診療ガイドライン2017」にもあるように、「慢性便秘症に対して刺激性下剤は有効であり、頓用または短期間の投与を提案する」とされている。慢性便秘症患者のQOLを改善することを念頭に、刺激性下剤の使用法を患者背景を参考に改めて見直す時期にきている。(著者抄録)

researchmap

その他リンク： https://search.jamas.or.jp/default/link?pub_year=2022&ichushi_jid=J00697&link_issn=&doc_id=20220113090010&doc_link_id=%2Fae4digta%2F2022%2F011001%2F012%2F0065-0068%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fae4digta%2F2022%2F011001%2F012%2F0065-0068%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

記述言語：英語   掲載種別：研究論文（学術雑誌）  

BACKGROUND: Early chronic pancreatitis (ECP) has been reported to advance into chronic pancreatitis, it may be critical to differentiate the pathophysiology of ECP and functional dyspepsia (FD) in patients with pancreatic enzyme abnormalities (FD-P). This study aimed to clarify differences in the pathophysiology of ECP and FD-P and to determine whether duodenal inflammatory responses in the two diseases were associated with protease-activated receptor (PAR) 2, as the trypsin receptor. METHODS: Eighty patients who presented with FD-P and ECP were enrolled. In duodenal specimens, PAR2 mRNA levels were determined using real-time PCR. Using immunostaining, CD68-, GLP-1-, PRG2-, and CCR2-positive cells, tight junction proteins, and PAR 2 were evaluated. RESULTS: There were no significant differences in clinical symptoms and gastric motility between ECP and FD-P patients. The CD68-positive cells infiltrations and occludin expression levels in the duodenal mucosa of patients with FD-P were significantly (p<0.001 and p = 0.048, respectively) lower than those in patients with ECP. Although serum trypsin levels in ECP and FD-P patents were significantly (p<0.05 and p<0.001, respectively) associated with duodenal eosinophils counts, elevated trypsin levels were not significantly associated with degranulated eosinophils, occludin, claudin-1 and ZO-1 expression levels in the duodenum of either group. PAR2 mRNA levels were increased in the duodenum of patients with ECP and FD-P. PAR2 was localized in the epithelial cells of the duodenal mucosa and the surface of degranulated eosinophils in ECP and FD-P patients. CONCLUSIONS: Elevated trypsin levels might be partly associated with duodenal inflammatory responses through PAR2-related degranulated eosinophils and the reduction of occludin in patients with ECP and FD-P.

DOI： 10.1371/journal.pone.0275341

PubMed

researchmap

記述言語：日本語   出版者・発行元：(一財)日本消化器病学会  

早期慢性膵炎は臨床症状,膵機能検査,超音波内視鏡検査所見を基に総合的に診断する.難治性心窩部痛患者に対し,trypsinを含む複数の膵酵素を測定し膵酵素異常を認めた場合に,積極的に超音波内視鏡検査を施行することが早期慢性膵炎の拾い上げに有効である.難治性心窩部痛患者に対しては,安易にPPIによる治療継続を行わず,非アルコール性早期慢性膵炎に対しては慢性膵炎に準じた治療により超音波内視鏡像の改善が期待できる.アルコール性の早期慢性膵炎患者もしくは非アルコール性早期慢性膵炎患者においても,dilated side branchesなどの超音波内視鏡所見をともなう患者に対しては慎重な経過観察が必要である.(著者抄録)

researchmap

その他リンク： https://search.jamas.or.jp/default/link?pub_year=2021&ichushi_jid=J01118&link_issn=&doc_id=20211216460002&doc_link_id=%2Fck8syokb%2F2021%2F011812%2F002%2F1098-1106%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fck8syokb%2F2021%2F011812%2F002%2F1098-1106%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：The Society for Free Radical Research Japan  

Since there were no available data about colonic diverticular bleeding in extremely elderly patients (>80 years old) treated with direct oral anticoagulants (DOACs), we tried to determine clinical characteristics in those with colonic diverticular bleeding taking DOACs and to compare clinical outcomes of those in DOAC-treated to those in warfarin-treated . We enrolled DOAC-treated (n = 20) and warfarin-treated (n = 23) extremely elderly patients with diverticular bleeding diagnosed by colonoscopy. We performed a retrospective review of patients' medical charts and endoscopic findings. We classified colonic diverticular bleeding based on endoscopic features due to modified previous study following three groups, type A (active bleeding), type B (non-active bleeding) and type C (bleeding suspected). Clinical outcomes such as number of recurrent bleeding, thrombotic events and mortality were estimated. There were no differences in endoscopical features and clinical characteristics between patients treated with DOAC and warfarin therapy. However, the number of recurrent bleeding, frequency of required blood transfusions and units of blood transfusion in warfarin-treated patients were significantly higher (p<0.05) compared to those in DOAC-treated groups. In addition, mortality and thrombotic events did not differ between DOAC- and warfarin-treated patients. Clinical outcomes suggest that DOACs can be recommended for extremely elderly patients with colonic diverticular disease.

DOI： 10.3164/jcbn.20-140

PubMed

researchmap

researchmap

記述言語：日本語   出版者・発行元：(株)南江堂  

researchmap

その他リンク： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2021&ichushi_jid=J00974&link_issn=&doc_id=20210407110020&doc_link_id=10.15106%2Fj_naika127_560&url=https%3A%2F%2Fdoi.org%2F10.15106%2Fj_naika127_560&type=%88%E3%8F%91.jp_%83I%81%5B%83%8B%83A%83N%83Z%83X&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

記述言語：日本語   出版者・発行元：(株)日本メディカルセンター  

＜文献概要＞機能性ディスペプシア(FD)はさまざまな要因が複合的に関与し症状発現につながるが,近年,十二指腸粘膜の炎症が注目されている.これまでにもFD患者では十二指腸粘膜のバリア機能障害と透過性亢進が報告されてきた.ストレスによる脳腸相関,胃酸や腸内細菌などの影響が十二指腸粘膜の炎症を引き起こし,バリア機能障害へとつながる可能性が指摘されており,今後の十二指腸の位置づけも含めて概説した.

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：The Society for Free Radical Research Japan  

Since the prevention of early chronic pancreatitis (ECP) into chronic pancreatitis might be critical for the reduction of pancreatic cancer, we tried to clarify the pathophysiology of ECP patients, focusing on ECP patients without alcoholic chronic pancreatitis. 27 ECP patients without alcoholic chronic pancreatitis and 33 patients with functional dyspepsia with pancreatic enzyme abnormalities (FD-P) were enrolled in this study. Diagnosis of ECP was made when imaging findings showed the presence of more than 2 out of 7 endoscopic ultrasound features. Duodenal degranulated eosinophils and glucagon-like peptide 1 producing cells were estimated by immunostaining. There were no significant differences in characteristics and psychogenic factors between ECP and FD-P patients. Interestingly, endoscopic ultrasound score in ECP patients significantly improved, albeit clinical symptoms in ECP patients showed no improvement at one year follow up. The extent of migration of duodenal degranulated eosinophils in FD-P patients was significantly higher compared to that in ECP patients. The levels of elastase-1 and trypsin in ECP patients with improved endoscopic ultrasound features were significantly reduced by the treatment. Further studies will be needed to clarify whether clinical symptoms and endoscopic ultrasound features in ECP patients without alcoholic chronic pancreatitis were improved in longer follow up study.

DOI： 10.3164/jcbn.19-130

PubMed

researchmap

記述言語：日本語   出版者・発行元：(株)医学書院  

＜文献概要＞はじめに-なぜ今,便秘症が注目されるのか 便秘症は日常臨床で最も多く遭遇する疾患の一つであるが,その疾患概念についてわが国では定義が定まっていなかった.2017年に日本消化器病学会関連研究会より「慢性便秘症診療ガイドライン」が発刊され,便秘の定義と分類,治療に関するエビデンスが収集され,消化器専門以外の医療従事者でも標準的な診断から治療までの見通しが可能となった.ガイドラインでは,便秘は「排出すべき糞便を十分量かつ快適に排出できない状態」と定義されている.これは疾患概念であり,問診時には次の4項目,(1)便の性状,(2)排便後の気分(残便感など),(3)排便時の気分(排便困難感など),(4)排便の頻度,を参考にするとよい(図1).患者の便秘に対する訴えは複雑であり,また複合的である.したがって臨床医は,排便回数や便の硬さなどの定型的なclosed questionにとどまらず,目の前にいる患者が,どの症状のために"便秘"であると訴えているのかを十分に聴取する必要がある.便秘治療の大きな変化として,新規治療薬の開発が挙げられる.便秘は以前より重要なcommon diseaseの一つであったが,最近まで使用できる薬剤が限られていたため,注目される疾患ではなかった.特に外科医にとっては加療の対象でなかったかもしれない.これまで治療薬としてはおもに,効果発現が早い大腸刺激性下剤であるアントラキノン系のセンノシド(プルゼニド),センナやジフェニール系のピコスルファート(ラキソベロン)などが頻用されてきたが,長期投与による効果減弱が指摘されており,患者の満足度も高くはなかった.しかし,2012年以降,新たな便秘症治療薬として,ルビプロストン(アミティーザ)が承認され,2017年にはリナクロチド(リンゼス),ナルデメジントシル酸塩(スインプロイク),2018年にエロビキシバット(グーフィス),ポリエチレングリコール(モビコール)と,新規治療薬が続々と上市されるに至った.近年登場した新薬は作用機序がそれぞれ異なり,これは,高齢者など多くの合併症をもった患者に対する薬剤処方の選択肢が大きく広がり,便秘治療にinnovationを引き起こすことを期待させる.ガイドラインが策定され,使える薬剤が増えたことで,便秘はもはや"漫然と"薬剤を使用し続ける疾患ではなくなっている.本稿では,特に新薬に着目しながら,慢性便秘症における最近の治療について述べたい.

researchmap

その他リンク： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2021&ichushi_jid=J01539&link_issn=&doc_id=20210108600021&doc_link_id=10.11477%2Fmf.1407213249&url=https%3A%2F%2Fdoi.org%2F10.11477%2Fmf.1407213249&type=%88%E3%8F%91.jp_%83I%81%5B%83%8B%83A%83N%83Z%83X&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

記述言語：日本語   掲載種別：研究論文（学術雑誌）  

DOI： 10.11405/nisshoshi.118.1098

PubMed

researchmap

記述言語：日本語   出版者・発行元：(公社)川崎市医師会  

researchmap

記述言語：日本語   出版者・発行元：(株)医学出版  

機能性胸やけ(functional heartburn)は、胸骨後方の焼けるような不快感や痛みがあるものの、酸の逆流が症状の原因ではないとされ、機能性消化管障害(Functional gastrointestinal disorders:FGIDs)の1つとして定義されている。診断基準は、(1)胸骨後方の焼けるような不快感や痛みがある、(2)酸の胃食道逆流が症状の原因ではない、(3)病理組織学的に食道運動障害を認めない、(4)PPIで症状が改善しない、などの4項目が少なくとも半年以上前からあり、少なくとも最近3ヵ月間症状が持続するものとされ、最新のRome IV基準でも定義されている。近年、機能性胸やけを含むFGIDsは増加傾向にあるとされ、その病態解明に注目が集まっている。食道粘膜局所の問題だけではなく、ストレスや不安によって生じる中枢神経における感受性の亢進も指摘されていることから考えると、機能性胸やけはGERDの一部として扱うのではなく、機能性ディスペプシアや過敏性腸症候群などの機能性消化管障害の一部としてとらえる方が妥当であると考えられる。機能性胸やけ患者の診断は、PPI抵抗性胸やけ患者の20～50%に及ぶとの報告がなされている。(著者抄録)

researchmap

記述言語：日本語   出版者・発行元：(株)医学出版  

機能性ディスペプシア(functional dyspepsia:FD)は、上腹部症状を主体とする機能性消化管障害(functional gastrointestinal functional disorders:FGIDs)に属する疾患である。2014年に、わが国においてもFD診療ガイドラインが作定された。このFD診療ガイドラインを基に、酸分泌抑制剤あるいは消化管運動機能改善薬あるいはその両剤を併用することでFDの診療が行われてきた。最近我々は、超音波内視鏡を用いて、プロトンポンプインヒビターやカリウムイオン競合型アシッドブロッカー(ボノプラザン)の内服によっても心窩部痛が改善しない、いわゆる難治性心窩部痛症候群の中に、早期慢性膵炎などの膵疾患が含まれていることを報告してきた。難治性FDとして長い間外来でフォローされていたFD群に対して、超音波内視鏡を行うことで見出した、早期慢性膵炎の患者に対して、慢性膵炎の治療を行った群と、アコチアミド+PPI製剤を用いたFDの1次治療を行った群を比較検討すると、慢性膵炎治療を行った群のほうが、心窩部痛が有意に改善された。このことは、超音波内視鏡を用い、難治性FDと考えられた患者群の中で、早期慢性膵炎の診断をつけ慢性膵炎に対する治療を行うことで、症状が軽快する患者群が確かに認められるため、超音波内視鏡を用いた診断を行う臨床的意義は大きいと考えられる。膵酵素異常を伴うディスペプシア群のごくわずかな患者は、超音波内視鏡を用いた経過観察において、早期慢性膵炎群へと進行することがわかっている。Masamuneらの多施設共同研究によれば、早期慢性膵炎患者の2年間の経過観察では、進行する患者は少数であり、進行する患者の多くはアルコール性であることがわかってきている。(著者抄録)

researchmap

記述言語：日本語   出版者・発行元：(一財)日本消化器病学会  

researchmap

その他リンク： https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2020&ichushi_jid=J01118&link_issn=&doc_id=20201020400006&doc_link_id=%2Fck8syokb%2F2020%2F011710%2F006%2F0876-0887%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fck8syokb%2F2020%2F011710%2F006%2F0876-0887%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

記述言語：英語   掲載種別：研究論文（学術雑誌）  

BACKGROUND: To determine whether central and in vitro administration of urocortin 2 (Ucn 2) affected intestinal inflammatory responses in LPS-stimulated rat models and macrophage cell lines and acotiamide modified mucosal inflammation in this model. METHODS: Rats were divided into four groups. LPS-stimulated group (n = 4); LPS- and urocortin 2-treated group (n = 4); LPS- and acotiamide-treated group (n = 4); and LPS-, urocortin 2-, and acotiamide-treated group (n = 4). CD68-, CCR2-, and corticotropin-releasing hormone receptor type 2 (CRHR2)-positive cells were assessed by immunostaining. Myeloperoxidase (MPO) activity was measured. TNF-α, IL-6, and IL-4 levels were measured by ELISA method. Gastric emptying and small intestinal transit time were determined using Evans blue. KEY RESULTS: Central administration of Ucn 2 significantly aggravated infiltrations of CD68- and CCR2-positive cells in the intestinal mucosa of LPS-stimulated rat models compared to those in LPS treatment alone. Interestingly, acotiamide treatment significantly reduced the migrations of both CD68- and CCR2-positive cells in the jejunum of central Ucn 2-treated LPS-stimulated rat models. Acotiamide significantly reduced the expression levels of IkB-α phosphorylation in LPS- and MCP-1-stimulated NR8383 cells. Central administration of Ucn 2 significantly delayed gastric emptying. In contrast, Ucn 2 stimulation significantly reduced TNF-α and IL-6 productions in LPS-stimulated NR8383 cells and astressin B reversed the inhibition of TNF-α production in stimulated NR8383 cells. Acotiamide (30 μmol/L) significantly reduced TNF-α and IL-6 productions in LPS- and MCP-1-stimulated NR8383 cells. CONCLUSIONS AND INFERENCES: Central and in vitro treatments of Ucn 2 affected intestinal inflammatory responses, respectively, and acotiamide improved them.

DOI： 10.1111/nmo.13813

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Functional dyspepsia (FD) is a common disease that can markedly impair quality of life. In the 2016 Rome IV criteria, a diagnosis of FD requires the presence of bothersome FD symptoms. In 2009, a new diagnosis, early chronic pancreatitis (ECP), was proposed as a means to facilitate early treatment of chronic pancreatitis and prevent progression to chronic pancreatitis. Although chronic pancreatitis was reported to be a cause of dyspepsia, data on the relation between ECP and FD patients are limited. We therefore investigated differences between ECP patients and FD patients in the percentages of those with severe epigastric pain, early satiety, and postprandial abdominal fullness. Several studies reported an association between the cause of chronic pancreatitis and endosonographic features. In addition, endosonography was useful for distinguishing ECP patients from FD patients with pancreatic enzyme abnormalities. Thus, we compared endosonographic characteristics in these patient groups. Future studies should attempt to determine why selected FD patients with pancreatic enzyme abnormalities develop ECP.

DOI： 10.1272/jnms.JNMS.2020_87-101

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Room-temperature Raman spectra of n-dodecane and methyl oleate were acquired at pressures up to 4 GPa. Both have monoalkyl chains with characteristic Raman rotamer profiles (trans and gauche conformers) along the skeletal CC bonds. The trans conformer was dominant in the high-pressure solid phase of n-dodecane. In solid methyl oleate, most of the gauche conformers transformed to the trans conformers. The all-trans dominated in the high-pressure solid phase and a triclinic subcell structure was indicated on the basis of previous vibrational spectra of n-alkanes and lipids. The solidification pressure of methyl oleate was determined against temperature up to 413 K.

DOI： 10.1016/j.saa.2019.117756

PubMed

researchmap

記述言語：日本語   出版者・発行元：(株)日本臨床社  

researchmap

記述言語：日本語   出版者・発行元：日本臨床生理学会  

血液検査や上下部内視鏡検査、腹部CT検査などで異常を認めない機能性消化管障害(FGIDs)は、主に非びらん性逆流性食道炎、機能性ディスペプシア(FD)、過敏性腸症候群の3つの疾患からなるとされている。FDでは他疾患とのオーバーラップの存在も知られている。筆者らの施設データを用いて、FDと早期慢性膵炎との関係性、超音波内視鏡を用いた鑑別診断について述べた。

researchmap

その他リンク： https://search.jamas.or.jp/default/link?pub_year=2019&ichushi_jid=J01210&link_issn=&doc_id=20191211380001&doc_link_id=%2Fcc8jjapf%2F2019%2F004905%2F001%2F0151-0154%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fcc8jjapf%2F2019%2F004905%2F001%2F0151-0154%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

記述言語：日本語   出版者・発行元：(一社)日本臨床薬理学会  

researchmap

記述言語：日本語   出版者・発行元：(一財)日本消化器病学会  

researchmap

記述言語：日本語   出版者・発行元：(株)日本臨床社  

researchmap

その他リンク： https://search.jamas.or.jp/default/link?pub_year=2019&ichushi_jid=J01205&link_issn=&doc_id=20190925180008&doc_link_id=%2Fag6niria%2F2019%2F007710%2F008%2F1625-1631%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fag6niria%2F2019%2F007710%2F008%2F1625-1631%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

記述言語：日本語   出版者・発行元：(株)ヴァンメディカル  

早期慢性膵炎が提言されてからちょうど10年、世界に先駆けた概念であった。時代は「平成」から「令和」になった。しかし、早期慢性膵炎の概念は慢性膵炎患者の早期発見・早期介入につながり、本当に予後の改善につながっているのだろうか。EUSの普及により徐々に診断されることが多くなっているが、まだ病名を知らない医療従事者も多い。早期慢性膵炎患者が不定愁訴として見過ごされ、埋もれていないだろうか。そして、診断された患者はどのような治療を受けるべきか、臨床の現場で漂流していないだろうか。本稿で早期慢性膵炎の診断と治療に関して述べたい。(著者抄録)

CiNii Books

CiNii Research

researchmap

その他リンク： https://search.jamas.or.jp/link/ui/2019369534

記述言語：英語   掲載種別：研究論文（学術雑誌）  

BACKGROUND AND AIMS: To determine whether serum acylated ghrelin levels were associated with anxiety, clinical symptoms, depressive status, quality of life, gastric motility and endoscopic findings based on Kyoto classification in functional dyspepsia (FD) patients. METHODS: We enrolled three groups, FD patients (n = 15) with high levels of acylated ghrelin, FD patients (n = 33) with normal levels of acylated ghrelin and FD patients (n = 35) with low levels of acylated ghrelin. There was no significant differences in the positivity of Helicobacter pylori infection among the three groups. Clinical symptoms were evaluated by Gastrointestinal Symptom Rating Scale (GSRS) and FD symptoms based on Rome III classification. Acylated ghrelin levels were measured by ELISA methods. Depressive status, anxiety, sleep disturbance were respectively asscessed by Self-rating questionnaire for depression (SRQ-D) score, STAI-state/-trait, Pittsburgh sleep quality index (PSQI) scores. Endoscopic findings were evaluated based on Kyoto classification. RESULTS: Body Mass Index (BMI) in FD patients with low levels of acylated ghrelin was significantly higher (p<0.001 and p = 0.008, respectively) compared to those in FD patients with high and normal levels of acylated ghrelin. SRQ-D scores in FD patients with low levels of acylated ghrelin was significantly lower (p = 0.008 and p<0.001, respectively) compared to those in FD patients with high and normal levels of acylated ghrelin. Scoring of gastric atrophy, intestinal metaplasia, xanthoma and mucus based on Kyoto classification in FD patients with low levels of acylated ghrelin were significantly higher (p<0.001, p = 0.0077, p = 0.036 and p = 0.0063, respectively) compared to those in FD patients with more than low levels of acylated ghrelin. CONCLUSION: Acylated ghrelin levels were associated with BMI, depressive status, and endoscopic findings based on Kyoto classification in FD patients.

DOI： 10.3164/jcbn.18-111

PubMed

researchmap

記述言語：日本語   出版者・発行元：(株)ライフ・サイエンス  

日本では急速に超高齢社会を迎え、消化器疾患構造においてもパラダイムシフトが起きている。現代において患者数が増加している疾患群として機能性消化管障害が知られているが、高齢者層においてもこの領域の疾患患者が増加している。胸やけ、呑酸などを訴える、非びらん性胃食道逆流症(Non-erosive gastroesophgeal reflux disease:NERD)や食後膨満感、早期飽満感、心窩部痛、心窩部灼熱感などの症状を訴える機能性ディスペプシア(Functional dyspepsia:FD)、便通異常と連動する腹痛・腹部不快感・腹部膨満感を訴える過敏性腸症候群(Irritable bowel syndrome:IBS)などである。いずれの疾患も内視鏡的に器質的疾患を認めないところが特徴である。高齢者のFD患者には、胃粘膜萎縮が進行したFD患者とH.pylori未感染の胃酸過多によるFD患者が認められる。一方で、高齢者の便秘症患者においては、IBS-C(便秘型IBS)に比較して機能便秘症(Functional constipation:FC)の割合が若年者より多い傾向にある。(著者抄録)

researchmap

記述言語：日本語   出版者・発行元：(一社)日本潰瘍学会  

ラットにLPS 600μgを腹腔内投与し、8日目にUrocortin 2.016μgを脳槽内に投与し、9日目に消化管粘膜を摘出した。LPS単独投与群、LPS+Urocortin投与群の2群に分け、ラットの回腸・空腸粘膜におけるCD68、CCR2の免疫染色を行い、粘膜内・筋層内で比較検討した。LPS+Urocortin II投与群における回腸・空腸粘膜の粘膜内・筋層内のCD68陽性細胞・CCR2陽性細胞数はLPS単独投与群と比べ有意に増加していた。さらにLPS+MCP-1刺激したラット由来マクロファージcell-line(NR8383)の上清中のIL-6、TNF-αレベルはLPS単独刺激群と比較して増加していた。LPS刺激Urocortin脳槽内投与ラットモデルではUrocortin投与により粘膜内・筋層内炎症細胞浸潤を認めたが、その増加にはラット由来マクロファージのIL-6やTNF-αが関与している可能性があることが示唆された。

researchmap

記述言語：日本語   出版者・発行元：(有)科学評論社  

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

BACKGROUND/AIMS: The aims of the study are to clarify the pathophysiological differences among early chronic pancreatitis (ECP), functional dyspepsia with pancreatic (FD-P) enzyme abnormalities and FD patients and to determine whether camostat mesilate, pancrelipase, and rabeprazole triple therapy improve FD symptoms in the ECP patients and FD-P patients in cross-over way. METHODS: We enrolled 84 consecutive patients presenting with typical symptoms of FD patients (n = 42), ECP patients (n = 15), and FD-P patients (n = 27). Gastric emptying was assessed by the 13C-acetate breath test. ECP was diagnosed based on the criteria recommended by the Japan Pancreatic Association. RESULTS: The proportions of female in ECP patients and FD-P were significantly higher compared to that in FD patients. The early phase of gastric emptying in ECP and FD-P patients was significantly disturbed compared to that in FD patients. The primary outcome of this study is that 4 weeks of camostat mesilate, pancrelipase, and rabeprazole triple therapy significantly ameliorated epigastric pain in ECP patients compared to acotiamide and rabeprazole combination therapy. CONCLUSION: Although there were no significant differences in pathophysiology between ECP patients and FD-P patients, triple therapy can significantly ameliorate epigastric pain in ECP patients. Further studies will be needed to clarify why triple therapy can improve epigastric pain in ECP patients.

DOI： 10.1159/000492813

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Background and Aims: Three-dimensional (3D) rigid endoscopy has been clinically introduced in surgical fields to enable safer and more accurate procedures. To explore the feasibility of 3D flexible endoscopy, we conducted a study comparing 2-dimensional (2D) and 3D visions for the performance of esophageal endoscopic submucosal dissection (ESD). Methods: Six endoscopists (3 experts and 3 trainees) performed ESD of target lesions in isolated porcine esophagus using a prototype 3D flexible endoscope under 2D or 3D vision. Study endpoints were procedure time, speed of mucosal incision and submucosal dissection, number of technical adverse events (perforation, muscle layer damage, and sample damage), and degree of sense of security, fatigue, and eye strain. Results: Procedure time and speed of mucosal incision/submucosal dissection were equivalent for 2D and 3D visions in both experts and trainees. The number of technical adverse events using 2D vision (mean [standard deviation], 3.5 [4.09]) tended to be higher than that using 3D vision in trainees (1.33 [2.80]; P = .06). In experts, 2D and 3D visions were equivalent. The degree of sense of security using 3D vision (3.67 [0.82]) was significantly higher than that using 2D vision (2.67 [0.52]) in trainees (P = .04), but was equivalent in experts. The degree of eye strain using 3D vision (3.00 [0.00]) was significantly higher than that using 2D vision (2.17 [0.41]) in trainees, but was equivalent in experts. Conclusions: 3D vision improves the sense of security during ESD and may reduce technical errors, especially in trainees, indicating the feasibility of a clinical trial of ESD under 3D vision.

DOI： 10.1155/2019/4051956

PubMed

researchmap

記述言語：日本語   出版者・発行元：(有)科学評論社  

researchmap

記述言語：日本語   掲載種別：研究論文（学術雑誌）   出版者・発行元：日本臨床生理学会  

近年、機能性消化管障害(Functional gastrointestinal disorders:FGIDs)の患者数は増加の一途を辿っている。機能性ディスペプシア(Functional dyspepsia:FD)はRome分類第IV版に従い、心窩部痛症候群(Epigastric pain syndrome:EPS)と食後愁訴症候群(Postprandial distress syndrome:PDS)の2つのグループに分けられる。Rome分類第IV版の中でも、FDの病因において脳腸相関は重要な役割を果たしていると述べられている。ほとんどのFD患者に非びらん性逆流性食道炎(Non-erosive reflux diseases:NERD)と過敏性腸症候群(Irritable bowel syndrome:IBS)のoverlapを認めており、さらに慢性膵炎とのoverlapも報告されている。我々は超音波内視鏡を用いてEPS患者群に含まれる早期慢性膵炎の有病率を調査した。5つの膵酵素を測定し、EPS患者の約40%に早期慢性膵炎を認めた。私たちは膵酵素の測定と超音波内視鏡による評価が機能性消化管障害の診断に有用であると考えている。(著者抄録)

researchmap

記述言語：日本語   出版者・発行元：(一社)日本潰瘍学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本潰瘍学会  

LPS刺激脳槽内urocortin投与ラットを用いて、ストレス下での感染刺激状態を作り出し、消化管粘膜内・筋層内炎症細胞浸潤に及ぼす影響について検討した。9週齢のSDラットをLPS単独投与群(n=4)、LPS+urocortin投与群(n=2)に分け、全ラットにLPS 600μgを腹腔内投与し1日目とした。2日目に脳室内手術を行った。空腸粘膜内では、LPS+urocortin投与群におけるCD68陽性細胞数、CCR2陽性細胞数は、LPS単独投与群でのCD68陽性細胞数、CCR2陽性細胞数に比較してともにそれぞれ有意に増加していた。また、空腸筋層下層においても同様に、LPS+urocortin投与群におけるCD68陽性細胞数、CCR2陽性細胞数は、LPS単独投与群でのCD68陽性細胞数、CCR2陽性細胞数に比較してともにそれぞれ有意に増加していた。加えて回腸筋層下層においても、LPS+urocortin投与群におけるCD68陽性細胞数、CCR2陽性細胞数は、LPS単独投与群でのCD68陽性細胞数、CCR2陽性細胞数に比較してともにそれぞれ有意に増加していた。

researchmap

記述言語：日本語   出版者・発行元：(一財)日本消化器病学会  

十二指腸は、胃内容物をアルカリ分泌によって中和する働きを持っている。加えてI細胞、K細胞、L細胞といったCCK、GIP、GLP-1産生細胞が十二指腸粘膜・小腸粘膜に局在しており、これらの消化管ホルモン産生により、栄養輸送に関わる消化管運動を制御しており、急激な十二指腸内腔への食物の流入を制限しているとされている。現在注目されている機能性消化管障害患者において、特に機能性ディスペプシア(FD)患者や慢性膵炎患者においても、食直後の胃・十二指腸運動の異常が報告されている。FD患者で報告されている十二指腸粘膜炎症および透過性の亢進との関連性については、その詳細な解析が待たれる。(著者抄録)

researchmap

その他リンク： https://search.jamas.or.jp/default/link?pub_year=2018&ichushi_jid=J01118&link_issn=&doc_id=20180223480005&doc_link_id=1390282681379822976&url=https%3A%2F%2Fcir.nii.ac.jp%2Fcrid%2F1390282681379822976&type=CiNii&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00003_3.gif

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：SAGE Publications Ltd  

Patients with functional dyspepsia, defined in the 2016 Rome IV criteria as bothersome clinical dyspepsia symptoms, experience markedly reduced quality of life. Several etiologies have been associated with the disorder. In the Rome IV criteria, the brain-gut axis was acknowledged as an important factor in the etiology of functional gastrointestinal (GI) disorders. The distinct subgroups of functional dyspepsia, epigastric pain syndrome (EPS) and postprandial distress syndrome (PDS), are treated differently: acid secretion inhibitors are recommended with patients with EPS, whereas prokinetic drugs as mosapride and acotiamide are recommended for patients with PDS. A previous study has reported that proton pump inhibitors (PPIs) and H2-blockers were equally effective in functional dyspepsia. A new drug, acotiamide, a muscarinic antagonist and cholinesterase inhibitor, has been shown to improve gastric motility in rodents and dogs, and to reduce PDS symptoms in patients in double-blind multicenter studies. The pharmacological mechanisms of acotiamide remain unknown; whether acotiamide alters gastric emptying and gastric accommodation in patients with functional dyspepsia remains an open question. Other emerging treatment options include Rikkunshito, a herbal medicine that improves gastric emptying through 5-hydroxytryptamine (5-HT)2B-mediated pharmacological action, and tricyclic antidepressants (TCAs). Different drugs are needed to accommodate the clinical symptoms and etiology in individual patients.

DOI： 10.1177/2040622317725479

Scopus

PubMed

researchmap

記述言語：英語  

DOI： 10.21037/tgh.2018.09.12

PubMed

researchmap

記述言語：日本語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Japanese Society of Gastroenterology  

DOI： 10.11405/nisshoshi.115.177

Scopus

researchmap

記述言語：日本語   出版者・発行元：一般財団法人 日本消化器病学会  

十二指腸は，胃内容物をアルカリ分泌によって中和する働きを持っている．加えてI細胞，K細胞，L細胞といったCCK，GIP，GLP-1産生細胞が十二指腸粘膜・小腸粘膜に局在しており，これらの消化管ホルモン産生により，栄養輸送に関わる消化管運動を制御しており，急激な十二指腸内腔への食物の流入を制限しているとされている．現在注目されている機能性消化管障害患者において，特に機能性ディスペプシア（FD）患者や慢性膵炎患者においても，食直後の胃・十二指腸運動の異常が報告されている．FD患者で報告されている十二指腸粘膜炎症および透過性の亢進との関連性については，その詳細な解析が待たれる．

DOI： 10.11405/nisshoshi.115.177

PubMed

CiNii Research

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

BACKGROUND: There was no available data concerning the clinical differentiation between the updated definition of early chronic pancreatitis (ECP) and anti-acid therapy-resistant functional dyspepsia (RFD). AIMS: We aimed to determine whether clinical symptoms, gastric motility, psychogenic factors and fat intake can help distinguish early chronic pancreatitis (ECP) from anti-acid therapy-resistant functional dyspepsia patients with pancreatic enzyme abnormalities (RFD-P) and anti-acid therapy-resistant functional dyspepsia (RFD) patients using endosonography. METHODS: We enrolled 102 consecutive patients presenting with typical symptoms of RFD patients (n = 52), ECP patients (n = 25) and RFD-P patients (n = 25). ECP patients were diagnosed based on the criteria recommended by the Japan Pancreatic Association. Gastric motility was evaluated by 13C-acetate breath tests. Severity of duodenal inflammation was examined. RESULTS: 24.5% of RFD patients were determined as ECP using endosonography. Abdominal pain score in Gastrointestinal Symptom Rating Scale (GSRS) in the patients with ECP was significantly lower compared to that in the patients with RFD-P. There were no significant differences in State-Trait Inventory (STAI)-state/-trait scores, Self-Rating Questionnaire for Depression (SRQ-D) scores and clinical symptoms for fat intake among three groups. The early phase of gastric emptying (AUC5; AUC15) in ECP and RFD-P patients were significantly disturbed compared to those in RFD patients. CONCLUSIONS: Evaluation of severity of abdominal pain and measurement of the early phase of gastric emptying will be useful tools to distinguish ECP patients from RFD patients. Accurate diagnosis of ECP patients may contribute to the prevention from advancing of chronic pancreatitis.

DOI： 10.1371/journal.pone.0205165

PubMed

researchmap

記述言語：日本語   出版者・発行元：(株)癌と化学療法社  

症例は70歳、女性。腹部CTにて腹壁浸潤を伴う閉塞性横行結腸癌と診断された。入院時の心電図にて広範にST低下を認めたため、冠動脈造影検査を施行した。冠動脈三枝に狭窄が指摘され狭心症と診断され、周術期合併症ハイリスク症例と判断した。治療は閉塞性大腸癌に対して大腸ステントを留置後、先に冠動脈バイパス術を施行した。心機能改善後、拡大結腸右半切除術+腹壁合併切除を施行した。術後合併症は認めず、病理所見上根治切除が可能であった。耐術能不良な閉塞性大腸癌に対し、大腸ステント留置により緊急手術を回避(bridge to surgery:BTS)することで、計画的な併存疾患の治療が可能となり、安全性かつ根治性に優れた結腸癌手術が可能であった。(著者抄録)

researchmap

その他リンク： https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2017&ichushi_jid=J00296&link_issn=&doc_id=20171221480273&doc_link_id=%2Fab8gtkrc%2F2017%2F004412%2F273%2F1868-1870%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fab8gtkrc%2F2017%2F004412%2F273%2F1868-1870%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

記述言語：日本語   出版者・発行元：(株)東京医学社  

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：JOURNAL CLINICAL BIOCHEMISTRY & NUTRITION  

There was not available data about the overlap between functional dyspepsia (FD) and pancreatic diseases. We aimed to determine whether epigastric pain syndrome (EPS) accompanying with pancreatic enzyme abnormalities were associated with early chronic pancreatitis proposed by Japan Pancreas Society (JPS) using endosonography. We enrolled 99 consecutive patients presenting with typical symptoms of FD, including patients with postprandial distress syndrome (PDS) (n = 59), EPS with pancreatic enzyme abnormalities (n = 41) and EPS without pancreatic enzyme abnormalities (n = 42) based on Rome Ill criteria. Gastric motility was evaluated using the C-13-acetate breath test. Early chronic pancreatitis was detected by endosonography and graded from 0 to 7. The ratio of female patients among EPS patients (34/41) with pancreatic enzyme abnormalities was significantly (p = 0.0018) higher than the ratio of female EPS patients (20/42) without it. Postprandial abdominal distention and physical component summary (PCS) scores in EPS patients with pancreatic enzyme abnormalities were significantly disturbed compared to those in EPS patients without it. Interestingly, AUC(5) and AUC(15) values (24.85 +/- 1.31 and 56.11 +/- 2.51, respectively) in EPS patients with pancreatic enzyme abnormalities were also significantly (p = 0.002 and p = 0.001, respectively) increased compared to those (19.75 +/- 1.01 and 47.02 +/- 1.99, respectively) in EPS patients without it. Overall, 64% of EPS patients with pancreatic enzyme abnormalities were diagnosed by endosonography as having concomitant early chronic pancreatitis proposed by JPS. Further studies are warranted to clarify how EPS patients with pancreatic enzyme abnormalities were associated with early chronic pancreatitis proposed by JPS.

DOI： 10.3164/jcbn.17-41

Web of Science

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：JOURNAL CLINICAL BIOCHEMISTRY & NUTRITION  

There was not available data about the overlap between functional dyspepsia (FD) and pancreatic diseases. We aimed to determine whether epigastric pain syndrome (EPS) accompanying with pancreatic enzyme abnormalities were associated with early chronic pancreatitis proposed by Japan Pancreas Society (JPS) using endosonography. We enrolled 99 consecutive patients presenting with typical symptoms of FD, including patients with postprandial distress syndrome (PDS) (n = 59), EPS with pancreatic enzyme abnormalities (n = 41) and EPS without pancreatic enzyme abnormalities (n = 42) based on Rome III criteria. Gastric motility was evaluated using the 13C-acetate breath test. Early chronic pancreatitis was detected by endosonography and graded from 0 to 7. The ratio of female patients among EPS patients (34/41) with pancreatic enzyme abnormalities was significantly (p = 0.0018) higher than the ratio of female EPS patients (20/42) without it. Postprandial abdominal distention and physical component summary (PCS) scores in EPS patients with pancreatic enzyme abnormalities were significantly disturbed compared to those in EPS patients without it. Interestingly, AUC5 and AUC15 values (24.85 ± 1.31 and 56.11 ± 2.51, respectively) in EPS patients with pancreatic enzyme abnormalities were also significantly (p = 0.002 and p = 0.001, respectively) increased compared to those (19.75 ± 1.01 and 47.02 ± 1.99, respectively) in EPS patients without it. Overall, 64% of EPS patients with pancreatic enzyme abnormalities were diagnosed by endosonography as having concomitant early chronic pancreatitis proposed by JPS. Further studies are warranted to clarify how EPS patients with pancreatic enzyme abnormalities were associated with early chronic pancreatitis proposed by JPS.

DOI： 10.3164/jcbn.17-41

Web of Science

PubMed

researchmap

記述言語：日本語   出版者・発行元：(株)じほう  

＜Points＞慢性便秘症の治療や薬剤の選択にあたっては、患者の便秘の訴えをよく聴取し、overlap症状の有無にも留意する。上皮機能変容薬として、わが国ではルビプロストンとリナクロチドが慢性便秘症、便秘型過敏性腸症候群に対して、それぞれ保険適用となっている。ルビプロストンは、CIC-2クロライドチャネルを活性化し、腸管内に浸透圧性の水分分泌を促進する。リナクロチドは、C型グアニル酸シクラーゼ受容体のアゴニストであり、C型グアニル酸シクラーゼ受容体の刺激を介して、腸管上皮細胞内のcGMP量を増加させる。増加したcGMPにより、腸管粘膜下の知覚神経刺激が抑制される。(著者抄録)

CiNii Books

researchmap

その他リンク： http://search.jamas.or.jp/link/ui/2017338966

記述言語：日本語   出版者・発行元：(株)メディカルレビュー社  

CiNii Research

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：KARGER  

BACKGROUND: Recent updated guidelines of the Japanese Society of Gastroenterology recommend the use of a single dose of antiplatelet agents in patients undergoing endoscopic submucosal dissection (ESD). However, the postoperative bleeding risk after gastric ESD associated with the continuation or interruption of antithrombotic therapy remains controversial. We aimed to evaluate whether certain factors including interrupted antithrombotic therapy could affect early and delayed post-ESD bleeding risk. METHODS: Three hundred sixty-four patients with gastric neoplasms were treated with ESD at our hospital between October 2005 and December 2012. Seventy-four patients with interrupted antithrombotic therapy were undertaken with ESD. Early and delayed postoperative bleeding patterns were estimated. Various clinical characteristics such as gender, age, tumor location, tumor size, ESD procedure time, platelet count, and comorbidity were evaluated. RESULTS: There was a significant difference (p = 0.042) in the ESD procedure time between the patients with postoperative bleeding and those without it. There was no significant difference in postoperative bleeding between the patients on antithrombotic therapy and not on it. Moreover, interrupted antithrombotic therapy and platelet count were significantly (p = 0.0461 and p = 0.0059, respectively) associated with early postoperative bleeding in multivariate analysis. In addition, in univariate analysis, ESD procedure time was significantly (p = 0.041) associated with delayed postoperative bleeding. CONCLUSIONS: Antithrombotic therapy and prolonged ESD procedure time were significantly associated with early and delayed postoperative bleeding, respectively.

DOI： 10.1159/000475924

Web of Science

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：KARGER  

BACKGROUND/AIMS: We aimed to clarify whether cyclooxygenase-2 (COX-2) and microsomal prostaglandin E synthase-1 (mPGES-1) genotypes were associated with certain histological findings and endoscopical appearances based on Kyoto classification. METHODS: We enrolled 285 Helicobacter pylori-infected gastritis patients. Genotypes of COX-2 1195, COX-2 1290, mPGES-1, interleukin-1β (IL-1β) 511 and tumour necrosis factor-α (TNF-α) 308 were analyzed. Genotyping was performed by polymerase chain reaction. Endoscopic appearances and histological assessment were determined by using Kyoto classification, operative link on gastritic intestinal metaplasia assessment and the updated Sydney system. RESULTS: There was a significant (p = 0.027) relationship between the IL-1β 511 C-carrier and histological gastric inflammation in H. pylori-infected gastritis patients. There was a significant (p = 0.009) correlation between the COX-2 1195 G-carrier genotype and histological intestinal metaplasia in the gastric antrum of H. pylori-infected gastritis patients and gastric xanthoma (p = 0.027). The COX-2 1195 G-carrier genotype was also significantly (p = 0.038) associated with the score of endoscopic intestinal metaplasia based on Kyoto classification. The mPGES-1 genotype was significantly (p = 0.002) associated with endoscopic swelling of area. CONCLUSION: Our results suggest that in Japan, there exists a significant correlation between the COX-2 1195 G-carrier genotype and intestinal metaplasia in histological and endoscopic findings based on Kyoto classification in H. pylori-infected gastric mucosa.

DOI： 10.1159/000479864

Web of Science

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：MEDICAL ASSOC NIPPON MEDICAL SCH  

Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School, Tokyo, Japan An 81-year-old man was admitted with upper abdominal pain and weight loss. Esophagogastroduodenoscopy revealed a large tumor located from the gastric angle to the body. Histological analysis of a biopsy revealed a moderately differentiated adenocarcinoma. Computed tomography revealed metastases in the liver and lung and the patient was subsequently diagnosed with metastatic advanced gastric cancer. He was treated with chemotherapy using S-1 (80 mg/m(2)) and cisplatin (CDDP) (60 mg/m(2)). Twenty-two months after chemotherapy, the gastric tumor, and the nodules in the liver and lung, had disappeared. We subsequently diagnosed a clinical complete response. The patient was treated with further S-1 monotherapy for 7 months after complete response assessment. He has lived for more than 7 years since the initial diagnosis without recurrence. Chemotherapy using S-1 and CDDP may be a potent strategy for improving survival in elderly patients with advanced gastric cancer.

DOI： 10.1272/jnms.83.199

Web of Science

PubMed

researchmap

記述言語：日本語   出版者・発行元：(株)東京医学社  

FD患者の訴えは、上腹部症状に加えて、NERDやIBSの症状も随伴することが多い。FDの病態には胃酸分泌や消化管運動機能異常以外に、感染症や心理的因子が関連しているため、消化器症状以外の他症状や患者背景まで考慮する必要がある。FDは食後愁訴症候群と心窩部痛症候群に分類され、消化管運動賦活薬、酸分泌抑制薬を用いることが多い。(著者抄録)

researchmap

その他リンク： https://search.jamas.or.jp/default/link?pub_year=2016&ichushi_jid=J03723&link_issn=&doc_id=20161117060011&doc_link_id=%2Faq9seijd%2F2016%2F004610%2F011%2F1281-1285%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Faq9seijd%2F2016%2F004610%2F011%2F1281-1285%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

記述言語：日本語   出版者・発行元：(一財)日本消化器病学会  

researchmap

その他リンク： https://search.jamas.or.jp/default/link?pub_year=2016&ichushi_jid=J01118&link_issn=&doc_id=20161026140006&doc_link_id=1390001206402987008&url=https%3A%2F%2Fcir.nii.ac.jp%2Fcrid%2F1390001206402987008&type=CiNii&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00003_3.gif

記述言語：日本語   出版者・発行元：(株)医学書院  

＜ポイント＞大腸癌や炎症性腸疾患による器質性狭窄による便秘を除外することが重要であり,alarm signがあれば積極的に消化管精査を勧める.慢性便秘症は,原発性の機能性便秘症と,基礎疾患・薬剤による二次性便秘症に分けられる.機能性便秘症を消化管運動能で分類すると,(1)結腸通過時間正常型,(2)排出障害型,(3)結腸通過時間遅延型に分けられる.(著者抄録)

researchmap

その他リンク： https://search.jamas.or.jp/default/link?pub_year=2016&ichushi_jid=J01440&link_issn=&doc_id=20160819160005&doc_link_id=10.11477%2Fmf.1402224307&url=https%3A%2F%2Fdoi.org%2F10.11477%2Fmf.1402224307&type=%E5%8C%BB%E6%9B%B8.jp_%E3%82%AA%E3%83%BC%E3%83%AB%E3%82%A2%E3%82%AF%E3%82%BB%E3%82%B9&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：WILEY-BLACKWELL  

Background The aim of this study is to clarify whether acotiamide and rabeprazole combination therapy can improve clinical symptoms, gastric emptying, and satisfaction with treatment in functional dyspepsia (FD) patients more effectively than acotiamide or rabeprazole monotherapy alone. We also aimed to determine whether acotiamide affects these changes via its effect on gastric emptying and appetite-related hormones such as ghrelin. Methods We used Rome III criteria to evaluate upper abdominal symptoms and anxiety by the State-Trait Anxiety Inventory (STAI). Gastric motility was evaluated by the 13 C-acetate breath test. Eighty-one FD patients were treated with acotiamide (300 mg/day) (n = 35), acotiamide (300 mg/day) and rabeprazole (10 mg/day) (n = 28), or rabeprazole (10 mg/day) (n = 18) for a period of 4 weeks and followed after 4 weeks of no treatment. Adenocorticotropic hormone (ACTH), cortisol, leptin and ghrelin levels were measured in all FD patients. Key Results Acotiamide and rabeprazole combination therapy significantly improved postprandial distress syndrome (PDS)-like symptoms (p = 0.018, p = 0.04 and p = 0.041, respectively) and epigastric pain (p = 0.024) as wells as STAI-state scores (p = 0.04) compared to rabeprazole monotherapy. Both acotiamide monotherapy, and acotiamide taken in combination with rabeprazole, significantly (p = 0.001 and p = 0.02, respectively) improved satisfaction with treatment, compared to rabeprazole monotherapy. Acotiamide and rabeprazole combination therapy had no significant effect on ACTH and cortisol levels in FD patients. Of interest, acotiamide monotherapy, and acotiamide and rabeprazole combination therapy, significantly (p &lt; 0.0001 and p = 0.018, respectively) increased acylated ghrelin/total ghrelin ratios and significantly (p = 0.04) improved impaired gastric emptying compared to rabeprazole monotherapy. Conclusions & Inferences Further studies are warranted to clarify how acotiamide treatment improves clinical symptoms in FD patients.

DOI： 10.1111/nmo.12805

Web of Science

researchmap

記述言語：日本語   掲載種別：研究論文（学術雑誌）   出版者・発行元：(一社)日本潰瘍学会  

上部消化管症状を訴えた機能性ディスペプシア(FD)患者25名を対象に、acotiamideを4週間投与し、上部消化管症状をVASで、下部消化管症状をGSRSで評価し、空腹時・安静下で採血して血清ACTH、cortisol値を測定した。Acotiamide投与後の食後腹満感、早期満腹感とも有意に改善し、便秘症状、下痢症状は改善傾向となった。STAIを用いた心気症状(不安)では有意な改善は得られなかった。血清ACTH値、cortisolとも投与後に有意な変化は認めなかった。

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：MEDICAL ASSOC NIPPON MEDICAL SCH  

An 81-year-old man was admitted with upper abdominal pain and weight loss. Esophagogastroduodenoscopy revealed a large tumor located from the gastric angle to the body. Histological analysis of a biopsy revealed a moderately differentiated adenocarcinoma. Computed tomography revealed metastases in the liver and lung and the patient was subsequently diagnosed with metastatic advanced gastric cancer. He was treated with chemotherapy using S-1 (80 mg/m2) and cisplatin (CDDP) (60 mg/m2). Twenty-two months after chemotherapy, the gastric tumor, and the nodules in the liver and lung, had disappeared. We subsequently diagnosed a clinical complete response. The patient was treated with further S-1 monotherapy for 7 months after complete response assessment. He has lived for more than 7 years since the initial diagnosis without recurrence. Chemotherapy using S-1 and CDDP may be a potent strategy for improving survival in elderly patients with advanced gastric cancer.

DOI： 10.1272/jnms.83.199

Web of Science

PubMed

researchmap

記述言語：日本語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Japanese Society of Gastroenterology  

DOI： 10.11405/nisshoshi.113.927

Scopus

PubMed

researchmap

記述言語：日本語   掲載種別：研究論文（学術雑誌）   出版者・発行元：(一財)日本消化器病学会  

機能性ディスペプシア(Functional Dyspepsia;FD)患者に対する治療薬acotiamideの登場により、FD診療の環境が整ってきた。H.pylori関連性FDの概念も注目され、心窩部痛症候群患者の病態として、膵機能異常が併存している可能性がある。また、FDの責任臓器として十二指腸粘膜が注目されており、炎症細胞の浸潤と粘膜透過性の亢進などの病態が注目されている。また、胃-十二指腸運動を制御するgut hormone分泌の起点としても重要である。機能性消化管障害において重要な役割を果たしている。脳腸相関についても解明が進んでいる。(著者抄録)

DOI： 10.11405/nisshoshi.113.927

researchmap

その他リンク： https://search.jamas.or.jp/default/link?pub_year=2016&ichushi_jid=J01118&link_issn=&doc_id=20160623110002&doc_link_id=1390001206403074944&url=https%3A%2F%2Fcir.nii.ac.jp%2Fcrid%2F1390001206403074944&type=CiNii&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00003_3.gif

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：JAPAN SOC INTERNAL MEDICINE  

DOI： 10.2169/internalmedicine.55.6223

Web of Science

PubMed

researchmap

記述言語：日本語   出版者・発行元：(株)医学書院  

＜ポイント＞機能性ディスペプシア(FD)の病態は胃酸分泌や消化管運動機能異常以外に,感染症や心理的因子が関連しているため,消化器症状以外の他症状や患者背景まで考慮する必要がある.FDは食後愁訴症候群と心窩部痛症候群に分類され,消化管運動賦活薬,酸分泌抑制薬を用いることが多い.(著者抄録)

researchmap

その他リンク： https://search.jamas.or.jp/default/link?pub_year=2015&ichushi_jid=J01440&link_issn=&doc_id=20150904040008&doc_link_id=10.11477%2Fmf.1402223695&url=https%3A%2F%2Fdoi.org%2F10.11477%2Fmf.1402223695&type=%E5%8C%BB%E6%9B%B8.jp_%E3%82%AA%E3%83%BC%E3%83%AB%E3%82%A2%E3%82%AF%E3%82%BB%E3%82%B9&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

記述言語：日本語   出版者・発行元：診断と治療社  

＜Headline＞ 1 FDの病態は胃酸分泌や消化管運動機能異常以外に、感染症や心理的因子が関連しているため、消化器症状以外の他症状や患者背景まで考慮する必要がある。2 感染を契機に発症した感染後FDは、消化管の粘膜炎症が原因と推測されるが、まだ病態は明らかでなく、食事摂取量が減少し体重減少を示すことなどの治療抵抗性を示すことがある。3 FD患者の臨床症状は睡眠障害と強い関係を認めると同時に、その睡眠障害はうつ症状のような精神面やQOLの低下に影響することがある。(著者抄録)

CiNii Books

researchmap

その他リンク： http://search.jamas.or.jp/link/ui/2015340782

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：KOREAN SOC NEUROGASTROENTEROLOGY & MOTILITY  

BACKGROUND/AIMS: There are no available data about the relationship between ghrelin gene genotypes and early phase of gastric emptying in functional dyspepsia (FD) as defined by Rome III classification. METHODS: We enrolled 74 patients presenting with typical symptoms of FD and 64 healthy volunteers. Gastric motility was evaluated using the 13C-acetate breath test. We used Rome III criteria to evaluate upper abdominal symptoms and self-rating questionnaires for depression (SRQ-D) scores to determine status of depression. The Arg51Gln (346G->A), preproghrelin (3056T->C), Leu72Met (408C->A), Gln90Leu (3412T->A) and G-protein 3 (825C->T) polymorphisms were analyzed in the DNA from blood samples of enrolled subjects. Genotyping was performed by polymerase chain reaction. RESULTS: There was a significant relationship between the Gln90Leu3412 genotype and SRQ-D score in FD patients (P = 0.009). Area under the curve at 15 minutes (AUC15) value was significantly associated with the Leu72Met408 genotype (P = 0.015) but not with entire gastric emptying. CONCLUSIONS: The Leu72Met (408C->A) single nucleotide polymorphism was significantly associated with early phase of gastric emptying in FD patients. Further studies will be necessary to clarify the association between ghrelin gene single nucleotide polymorphisms and early phase of gastric emptying in FD patients.

DOI： 10.5056/jnm14086

Web of Science

PubMed

researchmap

記述言語：日本語  

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：KOREAN SOC NEUROGASTROENTEROLOGY & MOTILITY  

BACKGROUND/AIMS: There is no available data on factors associated with healthcare-seeking behavior for functional dyspepsia (FD) symptoms at ei-ther tertiary or primary clinics in Japan. Therefore, we aimed to compare clinical symptoms and life styles such as sleep dis-orders and eating attitude in FD patients visiting general practitioners at primary clinics with those consulting gastro-enterologists at tertiary clinics to clarify healthcare-seeking patterns in Japanese patients. METHODS: Fifty-one FD outpatients in a tertiary clinic (college hospital), 50 FD outpatients visiting primary clinics and 50 healthy volunteers were enrolled. Clinical symptoms, quality of life, sleep disorders, eating attitude and anxiety were estimated using the Gastroin-testinal Symptom Rating Scale (GSRS), Social Functioning-8 (SF-8) test, Pittsburg Sleep Quality Index (PSQI) test and State-Trait Anxiety Inventory (STAI) for FD outpatients and healthy volunteers. RESULTS: FD outpatients exhibited higher mean scores of GSRS than healthy volunteers. The SF-8 physical component summary scores in the tertiary clinic group were significantly lower than those in the primary clinic group. GSRS scores were significantly (P < 0.001, P = 0.002) associated with global PSQI scores in FD outpatients as well as with STAI-trait scores (P = 0.006, P = 0.001) compared to healthy volunteers. The frequency of eating between meals in the primary clinic group was significantly (P < 0.05) higher than that in the tertiary clinic group. CONCLUSIONS: It may be important for clarification of healthcare-seeking behavior to determine the difference in both impairment of physical quality of life and eating attitudes between tertiary clinic and primary clinic FD outpatients in Japan.(J Neurogastroenterol Motil 2014;20:506-515).

DOI： 10.5056/jnm14015

Web of Science

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

A new intermediate phase (phase II) was found between phases I and III in LiNH2 in the pressure range of 10 to 13 GPa through the analysis of infrared and powder X-ray diffraction measurements to 25 GPa at room temperature. This result agreed with the prediction of a stable phase between phases I and III through theoretical calculations. Powder X-ray diffraction measurement and DFT calculation showed that this phase has a monoclinic structure with space group C2/c (Z = 8), which is the same structure as that of a slightly tilted crystal lattice of the Fddd structural model. The enthalpy of the C2/c structure was also found to be almost the same as that of the Fddd structure.

DOI： 10.1021/jp505133q

PubMed

researchmap

記述言語：日本語   掲載種別：研究論文（学術雑誌）   出版者・発行元：消化器心身医学研究会  

機能性ディスペプシア(FD)の病態は複雑であり、(1)知覚過敏、(2)消化管運動異常、(3)精神的ファクターなどが原因として挙げられている。最近になり、急性消化管感染症が改善した後にも、FD症状が持続する感染後FDが注目されている。この感染後FDは難治性であり、体重減少、早期飽満感などを伴うことが多いとされている。これら、感染後FDの原因となる病原体は様々であり、機序を含め今後の解明が待たれる。(著者抄録)

DOI： 10.11415/jpdd.21.12

researchmap

その他リンク： https://search.jamas.or.jp/default/link?pub_year=2014&ichushi_jid=J02916&link_issn=&doc_id=20150728250003&doc_link_id=%2Fcw8jmpdd%2F2014%2F002101%2F003%2F0012-0015%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fcw8jmpdd%2F2014%2F002101%2F003%2F0012-0015%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：AMER PHYSIOLOGICAL SOC  

Apurinic/apyrimidinic endonuclease-1 (APE-1) is a key enzyme responsible for DNA base excision repair and is also a multifunctional protein such as redox effector for several transcriptional factors. Our study was designed to investigate APE-1 expression and to study its interaction with cyclo-oxygenase (COX)-2 expression and VEGF production in the esophageal cancer. The expression of APE-1, COX-2, monocyte chemoattractant protein (MCP)-1, CC-chemokine receptor (CCR) 2, and VEGF were evaluated by immunohistochemistry in 65 human esophageal squamous cell carcinoma (ESCC) tissues. Real-time PCR and Western blotting were performed to detect mRNA and protein expression of APE-1 and p-signal transducer and activator of transcription 3 (STAT3) expression in MCP-1-stimulated ESCC cell lines (KYSE 220 and EC-GI-10). siRNA for APE-1 was treated to determine the role of APE-1 in the regulation of COX-2 expression, VEGF production, and antiapoptotic effect against cisplatin. In human ESCC tissues, nuclear localization of APE-1 was observed in 92.3% (60/65) of all tissues. There was a significant relationship (P = 0.029, R = 0.49) between nuclear APE-1 and cytoplasmic COX-2 expression levels in the esophageal cancer tissues. In KYSE 220 and EC-GI-10 cells, MCP-1 stimulation significantly increased mRNA and protein expression of APE-1. Treatment with siRNA for APE-1 significantly inhibited p-STAT3 expression levels in MCP-1-stimulated cells. Furthermore, treatment of siRNA for APE-1 significantly reduced COX-2 expression and VEGF production in MCP-1-stimulated esophageal cancer cell lines. Treatment with APE-1 siRNA significantly increased apoptotic levels in cisplatin-incubated KYSE 220 and EC-GI-10 cells. We concluded that APE-1 is overexpressed and associated with COX-2 expression and VEGF production in esophageal cancer tissues.

DOI： 10.1152/ajpgi.00057.2013

Web of Science

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：AMER PHYSIOLOGICAL SOC  

Apurinic/apyrimidinic endonuclease-1 (APE-1) is a key enzyme responsible for DNA base excision repair and is also a multifunctional protein such as redox effector for several transcriptional factors. Our study was designed to investigate APE-1 expression and to study its interaction with cyclooxygenase (COX)-2 expression and VEGF production in the esophageal cancer. The expression of APE-1, COX-2, monocyte chemoattractant protein (MCP)-1, CC-chemokine receptor (CCR)2, and VEGF were evaluated by immunohistochemistry in 65 human esophageal squamous cell carcinoma (ESCC) tissues. Real-time PCR and Western blotting were performed to detect mRNA and protein expression of APE-1 and p-signal transducer and activator of transcription 3 (STAT3) expression in MCP-1-stimulated ESCC cell lines (KYSE 220 and EC-GI-10). siRNA for APE-1 was treated to determine the role of APE-1 in the regulation of COX-2 expression, VEGF production, and antiapoptotic effect against cisplatin. In human ESCC tissues, nuclear localization of APE-1 was observed in 92.3% (60/65) of all tissues. There was a significant relationship (P = 0.029, R = 0.49) between nuclear APE-1 and cytoplasmic COX-2 expression levels in the esophageal cancer tissues. In KYSE 220 and EC-GI-10 cells, MCP-1 stimulation significantly increased mRNA and protein expression of APE-1. Treatment with siRNA for APE-1 significantly inhibited p-STAT3 expression levels in MCP-1-stimulated cells. Furthermore, treatment of siRNA for APE-1 significantly reduced COX-2 expression and VEGF production in MCP-1-stimulated esophageal cancer cell lines. Treatment with APE-1 siRNA significantly increased apoptotic levels in cisplatin-incubated KYSE 220 and EC-GI-10 cells. We concluded that APE-1 is overexpressed and associated with COX-2 expression and VEGF production in esophageal cancer tissues.

DOI： 10.1152/ajpgi.00057.2013

Web of Science

PubMed

researchmap

記述言語：日本語   出版者・発行元：(有)科学評論社  

CiNii Books

researchmap

その他リンク： http://search.jamas.or.jp/link/ui/2014127222

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：KOREAN SOC NEUROGASTERONTEROL & MOTILITY  

BACKGROUND/AIMS: The association between clinical symptoms, gastric emptying, quality of life and sleep disorders in distinct functional dyspepsia (FD) patients has not been studied yet in detail. METHODS: We enrolled 79 FD patients (postprandial distress syndrome [PDS], n = 65; epigastric pain syndrome [EPS], n = 47; EPS-PDS overlap, n = 33) and 44 healthy volunteers. Gastric motility was evaluated. We used Rome III criteria to evaluate clinical symptoms and State-Trait Anxiety Inventory (STAI) scores to determine anxiety status. Sleep disorder was evaluated using the Pittsburgh Sleep Quality Index scores. RESULTS: There were no significant differences in age, sex and Helicobacter pylori positivity between FD subtypes and healthy volunteers. The scores of Glasgow dyspepsia severity scores (GDSS), SF-8 and Pittsburgh Sleep Quality Index (PSQI) in distinct subtypes of FD patients were significantly different from those in healthy volunteers. However, there were not significant differences in these scores, Tmax and T1/2 among 3 subtypes of FD patients. PSQI score was significantly (P = 0.027, P = 0.002 and P = 0.039, respectively) associated with GDSS among EPS, PDS and EPS-PDS overlap patients. In addition, 8-item short form health survey (SF-8; Physical Component Score and Mental Component Score) was significantly associated with global PSQI score in PDS and EPS-PDS overlap patients. In contrast, SF-8 (Mental Component Score) only was significantly linked to global PSQI score in EPS patients. CONCLUSIONS: Prevalences for sleep disorders, gastric motility and quality of life in 3 subtypes of FD patients were similar levels. In PDS and EPS-PDS overlap patients, SF-8 was significantly associated with global PSQI score.

DOI： 10.5056/jnm.2014.20.1.104

Web of Science

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：WILEY-BLACKWELL  

BACKGROUND AND AIMS: The association between functional dyspepsia (FD) and sleep disorders has yet to be studied in detail. The aim of this study is to evaluate the risk factors associated with sleep disorders and the clinical response to nizatidine therapy for sleep disorders in Rome III-based FD patients. METHODS: We enrolled 94 FD patients and 52 healthy volunteers. We used Rome III criteria to evaluate upper abdominal symptoms, and the Self-Rating Questionnaire for Depression scores to determine depression status. Sleep disorder was evaluated using Pittsburgh Sleep Quality Index (PSQI) scores, and degree of anxiety by the State-Trait Anxiety Inventory. Gastric motility was evaluated. Thirty-four FD patients were treated with nizatidine (300 mg/day) or placebo for 4 weeks in a crossover trial. The primary end point of this study was to determine whether nizatidine could improve clinical symptoms and sleep disorders in FD patients. RESULTS: The global PSQI score for FD patients was significantly (P < 0.001) higher compared with healthy volunteers. There were significant correlations between global PSQI scores and total Gastrointestinal Symptom Rating Scale and Self-Rating Questionnaire for Depression scores (P < 0.001, P < 0.0001, respectively) in FD patients than in healthy volunteers. We found significant relationships between subjective sleep quality and both Tmax and T1/2 values in FD patients. Nizatidine significantly improved certain clinical symptoms, gastric emptying, and global PSQI score compared with placebo treatment. CONCLUSION: Sleep disorders in FD patients correlated significantly with both clinical symptoms of dyspepsia and depression compared with healthy volunteers. Nizatidine significantly improved gastroesophageal reflux symptoms, gastric emptying, and sleep disorders in FD patients.

DOI： 10.1111/jgh.12236

Web of Science

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.3164/jcbn.12-95

Web of Science

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：MEDICAL ASSOC NIPPON MEDICAL SCH  

BACKGROUND/AIMS: The association between clinical symptoms and sleep disorders in functional dyspepsia (FD)-overlap syndrome has not been studied in detail. METHODS: The subjects were 139 patients with FD, 14 with irritable bowel syndrome (IBS), 12 with nonerosive reflux disease (NERD), and 41 healthy volunteers. Gastric motility was evaluated with the (13)C-acetate breath test. We used Rome III criteria to evaluate upper abdominal symptoms, and Self-Rating Questionnaire for Depression (SRQ-D) scores to determine depression status. Sleep disorders were evaluated with Pittsburgh Sleep Quality Index (PSQI) scores. RESULTS: There were no significant differences in age, body-mass index, alcohol intake, and smoking rate between patients with FD alone and those with FD-overlap syndrome. The postprandial abdominal fullness score in patients with FD-NERD-IBS was significantly greater than that in patients with FD-NERD overlap syndrome (p<0.001) or FD alone (p<0.001). The score for the feeling of hunger in patients with FD-NERD-IBS was significantly greater than that in patients with FD alone (p=0.0025), FD-NERD overlap syndrome (p=0.0088), or FD-IBS overlap syndrome (p=0.0057). The heartburn score in subjects with FD-NERD-IBS overlap syndrome was significantly greater than that in subjects with FD alone (p=0.0035) or FD-IBS overlap syndrome (p=0.0026). The Tmax in patients with FD-overlap syndrome or FD alone was significantly higher than that in healthy volunteers. The Pittsburgh Sleep Quality Index score in subjects with FD-NERD-IBS overlap syndrome was significantly greater than that in subjects with FD alone. CONCLUSION: Symptom scores, such as those for postprandial abdominal fullness, heartburn, and the feeling of hunger, in patients with FD-overlap syndromes are significantly greater than those in patients with FD alone. Further studies are necessary to clarify whether various symptoms are related to sleep disorders in patients with FD-NERD-IBS overlap syndrome.

DOI： 10.1272/jnms.80.362

Web of Science

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Sleep disorder is a common medical problem. Sleep disorder has been associated with several diseases, including pulmonary disease, gastroesophageal reflux disease (GERD) and fibromyalgia. Interest in sleep phenomenology and gastrointestinal functioning has recently increased, because sleep disorder causes significant morbidity, as evidenced by the increased need for general medical and mental health treatment for emotional problems. A number of studies have found an association between sleep disorders and functional gastrointestinal (GI) disorders. Although arousal from sleep serves several protective roles, such as increase in the speed of esophageal clearance and in airway refluxes to prevent aspiration, awakening from sleep unfortunately induces impairment of sleep quality. Some investigations about the relationship between psychogenic factors and gut motility are controversial. In addition, reports of alterations in gut motility during sleep have also been contradictory. We have evaluated sleep disorder in functional dyspepsia (FD) patients using Pittsburgh Sleep Quality Index (PSQI) score. In our recent data, PSQI score of FD patients was significantly higher compared to that in healthy volunteers. Another study has reported that the distribution of subjects who thought that they got enough sleep was significantly lower for the FD/irritable bowel syndrome (IBS) subjects than for control subjects. Several studies have reported that anti-acid therapy and prokinetic agents are effective for certain FD patients. In addition, previous study has reported tricyclic antidepressants (TCA) drugs are effective for some FD patients. Finally, new drug, actiamide, a muscarinic antagonist and cholinesterase inhibitor, significantly improves Postprandial Distress Syndrome (PDS) symptoms. It might be critical issues for determination of precise mechanism for functional gastrointestinal disorders to clarify the relationship between gut motility and sleep disorders.

DOI： 10.1272/jnms.80.104

Scopus

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：JAPAN SOC INTERNAL MEDICINE  

OBJECTIVE: An impairment of gastric motility is strongly associated with the pathophysiology of functional dyspepsia (FD). Plasma ghrelin is one of the key molecules linked to gastric motility. Therefore, this study aimed to evaluate whether ghrelin (GHRL) gene polymorphisms are associated with clinical symptoms, the plasma ghrelin levels and gastric emptying in patients with FD as defined by the Rome III classification. METHODS: We enrolled 74 Helicobacter pylori-negative patients presenting with typical symptoms of FD (epigastric pain syndrome (EPS), n=23; postprandial distress syndrome (PDS), n=51) and 102 healthy volunteers. Gastric motility was evaluated according to the Tmax value and T1/2 using the (13)C-acetate breath test. We used the Rome III criteria to evaluate upper abdominal symptoms and SRQ-D scores to determine the depression status. The Arg51Gln(346G->A), preproghrelin3056T->C, Leu72Met(408C->A) and Gln90Leu(3412T->A) polymorphisms were analyzed in DNA in blood samples obtained from the enrolled subjects. Genotyping was performed using polymerase chain reaction. RESULTS: There was a significant relationship (p=0.048) between the preproghrelin 3056TT genotype and the serum levels of acylated ghrelin in the H. pylori-negative FD patients. The preproghrelin 3056TT genotype was significantly (p=0.047) associated with the feeling of hunger in the H. pylori-negative FD patients. CONCLUSION: The preproghrelin 3056TT genotype is significantly associated with the acylated ghrelin levels and the feeling of hunger in H. pylori-negative FD patients. Further studies are needed to clarify the association between the preproghrelin 3056TT genotype and lower plasma acylated ghrelin levels and the impact of this relationship on the feeling of hunger in H. pylori-negative FD patients.

DOI： 10.2169/internalmedicine.52.8662

Web of Science

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：CENTER ACADEMIC PUBL JAPAN  

We investigated over time whether contemporary Japanese patients with complicated peptic ulcers have any water-soluble vitamin deficiencies soon after the onset of the complicated peptic ulcers. In this prospective cohort study, fasting serum levels of water-soluble vitamins (vitamins B1, B2, B6, B12, C, and folic acid) and homocysteine were measured at 3 time points (at admission, hospital discharge, and 3 mo after hospital discharge). Among the 20 patients who were enrolled in the study, 10 consecutive patients who completed measurements at all 3 time points were analyzed. The proportion of patients in whom any of the serum water-soluble vitamins that we examined were deficient was as high as 80% at admission, and remained at 70% at discharge. The proportion of patients with vitamin B6 deficiency was significantly higher at admission and discharge (50% and 60%, respectively, p<0.05) than at 3 mo after discharge (10%). In conclusion, most patients with complicated peptic ulcers may have a deficiency of one or more water-soluble vitamins in the early phase of the disease after the onset of ulcer complications, even in a contemporary Japanese population.

DOI： 10.3177/jnsv.59.503

Web of Science

PubMed

researchmap

記述言語：日本語   出版者・発行元：(一社)東京内科医会  

researchmap

記述言語：日本語   掲載種別：研究論文（学術雑誌）   出版者・発行元：日本臨床生理学会  

器質的には何も問題が認められないにもかかわらず、上腹部の不快感や痛みなどの腹部症状が存在する機能性ディスペプシア(Functional dyspepsia:FD)は、近年発症する患者が増加しており注目されている。今回我々がFD患者の睡眠障害と胃排出能の関連を検討したところ、Control群においては胃排出時間(Tmax)と主観的睡眠・入眠時間とに有意な相関関係があるが、FD群においては相関は見られないという結果が得られた。また、睡眠と酸逆流症状との相関をみると、FD患者では、酸逆流症状と主観的睡眠・睡眠困難との間に有意な相関がみとめられた。このことからGERDだけでなくFDにおいても酸逆流症状と睡眠障害との相関関係が認められる可能性があることが示唆された。(著者抄録)

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：KARGER  

Background/Aims: In this crossover study, we investigated whether nizatidine, a H-2-receptor antagonist, can alleviate clinical symptoms and gastric emptying in patients with Rome III-based functional dyspepsia (FD) with or without impaired gastric emptying. Methods: We enrolled 30 patients presenting with FD symptoms (epigastric pain syndrome, n = 6; postprandial distress syndrome, n = 24). Rome III-based FD patients were treated with nizatidine (300 mg/day) or placebo for 4 weeks in a crossover trial. Gastric motility was mainly evaluated with the Tmax value using the 13 C-acetate breath test. Meal-related symptoms were defined as postprandial fullness and early satiation. Gastroesophageal symptom was defined as a burning feeling rising from the stomach or lower chest up toward the neck. Acylated- and desacylated ghrelin levels were evaluated by the ELISA method. Clinical symptoms, gastric emptying and ghrelin levels were evaluated at three different points during the study (pretreatment, after 4 weeks former treatment and after 4 weeks later treatment). The primary end point of this study was to determine whether nizatidine would improve clinical symptoms and gastric emptying in FD patients with or without impaired gastric emptying via affecting ghrelin levels. Results: Meal-related symptoms of the patients treated with nizatidine improved significantly (21/30; 70%) compared to those treated with placebo (3/30; 10%). In addition, nizatidine treatment also significantly improved gastro-esophageal symptoms (16/30; 53%) compared to those treated with placebo (0/30; 0%). Nizatidine treatment in patients with FD accompanied by impaired gastric emptying significantly improved clinical symptoms and T-max value as a marker of gastric emptying (10/11, 91%; 9/11, 82%) compared to placebo therapy, respectively. There were no significant differences in ghrelin levels between nizatidine treatment and placebo therapy. Conclusion: Nizatidine administration significantly improved both gastric emptying and clinical symptoms in FD patients with impaired gastric emptying. Copyright (c) 2012 S. Karger AG, Basel

DOI： 10.1159/000339111

Web of Science

researchmap

記述言語：日本語   出版者・発行元：(一社)日本消化管学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本消化管学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本消化器内視鏡学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本ヘリコバクター学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本ヘリコバクター学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本消化器内視鏡学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本消化管学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本消化管学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本消化管学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本消化器内視鏡学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本消化器内視鏡学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本消化器内視鏡学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本潰瘍学会  

researchmap

記述言語：日本語   出版者・発行元：(一財)日本消化器病学会  

researchmap

記述言語：日本語   出版者・発行元：(一財)日本消化器病学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本消化器内視鏡学会-関東支部  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本消化器内視鏡学会-関東支部  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本消化器内視鏡学会-関東支部  

researchmap

記述言語：日本語   出版者・発行元：日本消化器病学会-関東支部  

researchmap

J-GLOBAL

researchmap

J-GLOBAL

researchmap

J-GLOBAL

researchmap

記述言語：日本語   出版者・発行元：(一財)日本消化器病学会  

researchmap

記述言語：日本語   出版者・発行元：(一財)日本消化器病学会  

researchmap

記述言語：日本語   出版者・発行元：(一財)日本消化器病学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本消化器内視鏡学会  

researchmap

記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）   出版者・発行元：MOSBY-ELSEVIER  

DOI： 10.1016/j.gie.2019.03.1085

Web of Science

researchmap

記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）   出版者・発行元：W B SAUNDERS CO-ELSEVIER INC  

0

Web of Science

researchmap

記述言語：日本語   出版者・発行元：(一財)日本消化器病学会  

researchmap

記述言語：日本語   出版者・発行元：(一財)日本消化器病学会  

researchmap

記述言語：日本語   出版者・発行元：(一財)日本消化器病学会  

researchmap

記述言語：日本語   出版者・発行元：(一財)日本消化器病学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本消化管学会  

researchmap

記述言語：日本語   出版者・発行元：日本消化器病学会-関東支部  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本消化管学会  

researchmap

J-GLOBAL

researchmap

J-GLOBAL

researchmap

記述言語：日本語   出版者・発行元：(一財)日本消化器病学会  

researchmap

記述言語：日本語   出版者・発行元：(一財)日本消化器病学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本消化器内視鏡学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本消化器内視鏡学会  

researchmap

記述言語：日本語   出版者・発行元：(一財)日本消化器病学会  

researchmap

記述言語：日本語   出版者・発行元：(一財)日本消化器病学会  

researchmap

記述言語：日本語   出版者・発行元：(一財)日本消化器病学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本消化管学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本消化管学会  

researchmap

J-GLOBAL

researchmap

J-GLOBAL

researchmap

記述言語：日本語   出版者・発行元：(一社)日本消化器内視鏡学会-関東支部  

researchmap

記述言語：日本語   出版者・発行元：日本臨床生理学会  

researchmap

記述言語：日本語   出版者・発行元：(一財)日本消化器病学会  

researchmap

記述言語：日本語   出版者・発行元：(一財)日本消化器病学会  

researchmap

記述言語：日本語   出版者・発行元：(一財)日本消化器病学会  

researchmap

記述言語：日本語   出版者・発行元：(一財)日本消化器病学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本消化器内視鏡学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本消化器内視鏡学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本ヘリコバクター学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本ヘリコバクター学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本ヘリコバクター学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本ヘリコバクター学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本ヘリコバクター学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本消化器内視鏡学会  

researchmap

記述言語：日本語   出版者・発行元：(一財)日本消化器病学会  

J-GLOBAL

researchmap

記述言語：日本語   出版者・発行元：(一社)日本消化器内視鏡学会-関東支部  

researchmap

記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）   出版者・発行元：WILEY-BLACKWELL  

Web of Science

researchmap

記述言語：日本語   出版者・発行元：(一財)日本消化器病学会  

researchmap

記述言語：日本語   出版者・発行元：(一財)日本消化器病学会  

researchmap

記述言語：日本語   出版者・発行元：(一財)日本消化器病学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本消化器内視鏡学会  

researchmap

記述言語：日本語   出版者・発行元：(一財)日本消化器病学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本消化器内視鏡学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本消化器内視鏡学会  

researchmap

記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）   出版者・発行元：WILEY-BLACKWELL  

Web of Science

researchmap

記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）   出版者・発行元：WILEY-BLACKWELL  

Web of Science

researchmap

記述言語：日本語   出版者・発行元：(一財)日本消化器病学会  

researchmap

記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）   出版者・発行元：WILEY-BLACKWELL  

Web of Science

researchmap

記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）   出版者・発行元：WILEY-BLACKWELL  

Web of Science

researchmap

記述言語：日本語   出版者・発行元：(一社)日本消化器内視鏡学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本消化器内視鏡学会  

researchmap

記述言語：日本語   出版者・発行元：(一財)日本消化器病学会  

researchmap

記述言語：日本語   出版者・発行元：(一財)日本消化器病学会  

researchmap

記述言語：日本語   出版者・発行元：日本臨床生理学会  

researchmap

記述言語：日本語   出版者・発行元：日本臨床生理学会  

researchmap

記述言語：日本語   出版者・発行元：日本臨床生理学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本癌治療学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本消化器内視鏡学会  

researchmap

記述言語：日本語   出版者・発行元：(一財)日本消化器病学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本消化器内視鏡学会  

researchmap

記述言語：日本語   出版者・発行元：(一財)日本消化器病学会  

researchmap

記述言語：日本語   出版者・発行元：(一財)日本消化器病学会  

researchmap

記述言語：日本語   出版者・発行元：(株)診断と治療社  

researchmap

その他リンク： https://search.jamas.or.jp/default/link?pub_year=2013&ichushi_jid=J00697&link_issn=&doc_id=20130213020018&doc_link_id=%2Fae4digta%2F2013%2F010102%2F019%2F0291-0295%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fae4digta%2F2013%2F010102%2F019%2F0291-0295%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

記述言語：日本語   出版者・発行元：(株)新興医学出版社  

Rome IIIではFDには食後愁訴症候群(PDS)と心窩部痛症候群(EPS)の2つのカテゴリーがある。FDの病態は多岐にわたるが、特に食後愁訴症候群(PDS)群では有意に胃排出能の遅延を認める。Gut hurmoneが消化管運動に影響しており、その中でもグレリンは胃運動能の促進効果がある。先行する感染症によりFDやIBSが発症することが報告されている。(著者抄録)

researchmap

記述言語：日本語   出版者・発行元：日本臨床生理学会  

researchmap

記述言語：日本語   出版者・発行元：(一財)日本消化器病学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本消化器内視鏡学会  

researchmap

記述言語：日本語   出版者・発行元：(一財)日本消化器病学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本消化器内視鏡学会  

researchmap

記述言語：日本語   会議種別：シンポジウム・ワークショップ パネル（公募）  

researchmap

記述言語：日本語   会議種別：ポスター発表  

researchmap

記述言語：日本語   会議種別：シンポジウム・ワークショップ パネル（公募）  

researchmap

記述言語：日本語   会議種別：シンポジウム・ワークショップ パネル（公募）  

researchmap

記述言語：日本語   会議種別：口頭発表（一般）  

researchmap

記述言語：日本語   会議種別：シンポジウム・ワークショップ パネル（公募）  

researchmap

記述言語：日本語   会議種別：シンポジウム・ワークショップ パネル（公募）  

researchmap

記述言語：日本語   会議種別：シンポジウム・ワークショップ パネル（公募）  

researchmap

記述言語：日本語   会議種別：口頭発表（一般）  

researchmap

記述言語：日本語   会議種別：口頭発表（一般）  

researchmap

記述言語：日本語   会議種別：口頭発表（一般）  

researchmap

記述言語：日本語   会議種別：シンポジウム・ワークショップ パネル（公募）  

researchmap

記述言語：日本語   会議種別：シンポジウム・ワークショップ パネル（公募）  

researchmap

記述言語：日本語   会議種別：口頭発表（一般）  

researchmap

記述言語：日本語   会議種別：口頭発表（一般）  

researchmap

記述言語：日本語   会議種別：シンポジウム・ワークショップ パネル（公募）  

researchmap

記述言語：日本語   会議種別：シンポジウム・ワークショップ パネル（公募）  

researchmap

記述言語：日本語   会議種別：シンポジウム・ワークショップ パネル（公募）  

researchmap

記述言語：日本語   会議種別：シンポジウム・ワークショップ パネル（公募）  

researchmap

記述言語：日本語   会議種別：シンポジウム・ワークショップ パネル（公募）  

researchmap

記述言語：日本語   会議種別：シンポジウム・ワークショップ パネル（公募）  

researchmap

記述言語：日本語   会議種別：シンポジウム・ワークショップ パネル（公募）  

researchmap