Updated on 2024/05/18

写真a

 
Takumi Sonokawa
 
Affiliation
Nippon Medical School Hospital, Department of Thoracic Surgery, Senior Assistant Professor
Title
Senior Assistant Professor
Profile
東邦大学卒業
日本医科大学附属病呼吸器外科助教
External link

Research Interests

  • Thoracic Surgery

Research Areas

  • Life Science / Respiratory surgery

Research History

Papers

  • Long-term outcomes of PDT for centrally-located early lung cancers with tumor diameters > 2.0 cm

    Takumi Sonokawa, Mitsunobu Ino, Satoshi Kera, Mariko Tanaka, Kento Suzuki, Yuuya Tomioka, Yuichiro Machida, Norihito Kawasaki, Jitsuo Usuda

    Photodiagnosis and Photodynamic Therapy   104200 - 104200   2024.5

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    Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.pdpdt.2024.104200

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  • A remarkable response to combination chemotherapy with nivolumab and ipilimumab in a patient with primary pulmonary choriocarcinoma: a case report

    Hirokazu Iso, Kakeru Hisakane, Naoki Terashi, Erika Mikami, Satoru Matsuki, Takumi Sonokawa, Kenichiro Atsumi, Naoyuki Yoshino, Kohji Nagata, Masahiro Seike, Takashi Hirose

    TRANSLATIONAL CANCER RESEARCH   2023.7

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：AME PUBLISHING COMPANY  

    Background: Primary pulmonary choriocarcinoma (PPC) is a rare malignancy, and only 41 PPC cases have been reported in males up to 2021. Due to its rarity, no standardized treatments for PPC have been established. Cytotoxic chemotherapy has limited efficacy, and the prognosis of advanced PPC is notably poor. Immune checkpoint inhibitors (ICIs) are expected to provide long-term survival for PPC patients, but only a few cases have been reported. The optimal treatment for PPC has not been determined.Case Description: Here, we report a 72-year-old male with post-surgery relapsed PPC, presenting with multiple pulmonary nodules and an intracardiac mass. The OncomineTM Dx target test showed no mutation of cancer-relevant genes, and programmed death-ligand 1 (PD-L1) expression was negative (0%) in the 22C3 assay. He received a combination of carboplatin, paclitaxel, nivolumab, and ipilimumab which is widely used as a first-line treatment for advanced non-small-cell lung cancer (NSCLC). Two months after treatment began, computed tomography (CT) showed multiple lung nodules and an intracardiac mass reduction, which has been sustained for 12 months. Grade 3 febrile neutropenia and grade 2 rash were observed, however, these adverse events were manageable. Conclusions: This is the first case of postoperative relapse PPC that has been successfully treated with the combination of chemotherapy, nivolumab, and ipilimumab. This therapy may be a promising option for advanced PPC.

    DOI： 10.21037/tcr-23-221

    Web of Science

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  • New Technique for Introducing a Surgical Stapler during Robot-Assisted Lobectomy for Lung Cancer.

    Jitsuo Usuda, Tatsuya Inoue, Takumi Sonokawa, Mitsuo Matsumoto, Yutaka Enomoto, Kento Suzuki, Yuuya Tomioka

    Journal of Nippon Medical School = Nippon Ika Daigaku zasshi   89 ( 2 )   169 - 175   2022.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: The da Vinci Si version robot lacks a vascular stapler that can be controlled by the operating surgeon at the surgical console when dividing pulmonary vessels. Therefore, to initiate and safely perform robotic anatomical lobectomy for lung cancer, it is important to develop a safe method for introducing a surgical stapler. METHODS: We performed a retrospective study of the first 42 consecutive patients who underwent robotic lobectomy for lung cancer at Nippon Medical School Hospital between January 2019 and December 2020. RESULTS: Up to case 18, we performed robot-assisted thoracoscopic surgery (RATS) lobectomy by using a four-arm approach with two assistant ports. For dividing pulmonary vessels, the surgical stapler was introduced through the assist ports. However, since this is not the port position usually used in video-assisted thoracoscopic surgery (VATS), there were many difficult situations. For RATS lobectomy case 19 and all subsequent cases, we utilized a total port approach that uses three robotic arms and two assistant ports. To resect the pulmonary vessels or bronchi with endoscopic staplers, the port for the robotic arm was removed and the endoscopic staplers were placed through a 12-mm Xcel bladeless port. This change reduced operation time, blood loss, and robotic arm interference. No patient developed intraoperative complications during RATS lobectomy. CONCLUSION: The present total port approach, with three robotic arms, appears to be feasible for introducing surgical staplers during RATS with the da Vinci Si robotic system.

    DOI： 10.1272/jnms.JNMS.2022_89-211

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  • The Ingenuity to Improve the Therapeutic Outcome of PDT for Centrally Located Lung Cancer

    Sonokawa Takumi, Suzuki Kento, Tomioka Yuuya, Matsumoto Mitsuo, Machida Yuichiro, Inoue Tatsuya, Enomoto Yutaka, Usuda Jitsuo

    The Journal of Japan Society for Laser Surgery and Medicine   43 ( 1 )   2 - 8   2022.4

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    Language：Japanese   Publisher：Japan Society for Laser Surgery and Medicine  

    Photodynamic therapy (PDT) is a standard treatment for centrally located early lung cancer. Accurate diagnosis of the tumor extent and appropriate application of laser irradiation are important for improving treatment outcome. However, some endoscopic systems are unsuitable for evaluating tumor extent after injecting taraporfin sodium, a photosensitizer, and because of the loss of color information with the use of strong laser light, complicating appropriate irradiation of the tumor. In this study, we investigated the ingenuity of PDT to improve the therapeutic outcome with the simultaneous use of endoscopic system ELUXEO 7000® (Fujifilm Corporation).

    DOI： 10.2530/jslsm.jslsm-43_0004

    CiNii Research

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  • Usefulness of simultaneous type image-enhanced endoscope system in photodynamic therapy for centrally located lung cancer. International journal

    Takumi Sonokawa, Mitsuo Matsumoto, Kyoshiro Takegahara, Tatsuya Inoue, Yutaka Enomoto, Jitsuo Usuda

    Photodiagnosis and photodynamic therapy   35   102345 - 102345   2021.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: Photodynamic therapy (PDT) is established as one of the standard treatment options for centrally located early lung cancer. In order to improve the effectiveness of PDT, it is very important to accurately diagnose the extent of the tumor and focus the laser irradiation accurately. With the use of the conventional video-endoscope system, which adopts the frame-sequential (RGB-based) display method, mainly used in Japan, for PDT laser irradiation, the system only recognizes the strong white light, and color information is lost. Therefore, it is difficult to irradiate the lesion while simultaneously observing the lesion. In this study, we investigated the usefulness of a new type of video-endoscope system during PDT. METHODS: We used ELUXEO 7000® (FUJIFILM, Japan), which is a simultaneous-type video-endoscope system that has been in use at Nippon Medical School Hospital since October 2018. We analyzed the clinical usefulness of the ELUXEO® system for PDT as compared to other endoscope systems, such as EVIS LUCERA ELITE® (Olympus, Japan), an autofluorescence imaging (AFI) system. RESULTS: After the administration of talaporfin sodium for PDT, the tumor lesion was not visualized in magenta color with AFI, yielding false-negative results. On the other hand, no false-negative results after the administration of talaporfin sodium were obtained with the use of ELUXEO®. Using the ELUXEO® system in the blue light imaging (BLI) mode, we were able to deliver a red laser light while observing the extent of the tumor. Missed laser exposure was avoided and the accuracy of PDT was improved with the use of this system. CONCLUSIONS: ELUXEO® is useful for accurate evaluation of the extent of centrally located lung cancer and therefore, for accurate laser irradiation of the tumor lesion.

    DOI： 10.1016/j.pdpdt.2021.102345

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  • 成人期に発見されたCPAM/CCAMの一切除例

    鈴木 健人, 富岡 勇宇也, 松本 充生, 園川 卓海, 竹ヶ原 京志郎, 井上 達哉, 榎本 豊, 臼田 実男

    日本呼吸器外科学会雑誌   35 ( 3 )   O16 - 6   2021.5

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  • Antiaging gene Klotho regulates epithelial-mesenchymal transition and increases sensitivity to pemetrexed by inducing lipocalin-2 expression. International journal

    Kyoshiro Takegahara, Jitsuo Usuda, Tatsuya Inoue, Takumi Sonokawa, Takuma Matsui, Mitsuo Matsumoto

    Oncology letters   21 ( 5 )   418 - 418   2021.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    Epithelial-mesenchymal transition (EMT) is considered to serve an important role in the metastatic/invasive ability of cancer cells, in the acquisition of drug resistance, and in metabolic reprogramming. In the present study, it was hypothesized that the Klotho gene is involved in the metastatic/invasive ability of lung cancer. We previously reported an association between Klotho expression and overall survival in patients with small cell lung cancer and large cell neuroendocrine cancer. We also found that Klotho expression was associated with EMT-related molecules in lung squamous cell carcinoma. The present study aimed to analyze the function of the Klotho gene and to elucidate its relevance to the regulation of the EMT. For this purpose, GFP-Klotho plasmids were transfected into lung adenocarcinoma cells (A549) and cell lines with stable expression (A549/KL-1 and A549/KL-2) were established. A549/KL-1 cells expressed higher levels of Klotho protein by western blot analysis compared with A549/KL-2 cells. In western blotting of A549 and A549/KL-1 cells, the expression of the mesenchymal marker N-cadherin was found to be completely inhibited in A549/KL-1 cells suggesting that Klotho expression may regulate the EMT in cancer cells via the inhibition of N-cadherin. The results of the sensitivity tests demonstrated that A549/KL-1 cells were significantly more sensitive to pemetrexed compared with A549 cells (IC50 A549/KL-1 vs. A549 cells, 0.1 µM vs. 0.7 µM). The results of the microarray analysis demonstrated that a very high level of lipocalin-2 (LCN2) expression was induced in the A549/KL-1 cells. Klotho overexpression completely suppressed the expression of mesenchymal markers, such as N-cadherin and Snail1 (Snail). The results of the present study suggested that there may be a new mechanism of action for the antitumor effects of pemetrexed, namely, LCN2-mediated modulation of N-cadherin expression. Klotho expression during cancer treatment has great potential as a predictor for efficacy of pemetrexed and as a factor in the selection of personalized medicine for postoperative adjuvant chemotherapy.

    DOI： 10.3892/ol.2021.12679

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  • A Case of Pulmonary Adenofibroma Treated by Thoracoscopic Resection.

    Takumi Sonokawa, Yutaka Enomoto, Shinobu Kunugi, Yasuhiro Terasaki, Jitsuo Usuda

    Journal of Nippon Medical School = Nippon Ika Daigaku zasshi   88 ( 6 )   564 - 568   2021

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    Pulmonary adenofibroma is a rare biphasic tumor that contains epithelial and stromal components. We report a case of pulmonary adenofibroma in which the tumor was resected by thoracoscopic surgery and the diagnosis was established by histopathology. A 59-year-old woman with a past medical history of pyelonephritis visited our hospital for evaluation of an abnormal opacity on a plain chest x-ray during a comprehensive medical examination. A follow-up chest x-ray showed enlargement of the lesion, and the patient was referred to our department for further management. Chest computed tomography revealed a well-circumscribed nodule measuring 1.4 cm in diameter in the upper lobe of the left lung. The chest imaging findings suggested a benign tumor, but because of evidence of lesion enlargement and elevated serum carcinoembryonic antigen levels, we performed wide wedge resection of the left upper lobe by video-assisted thoracoscopic surgery, for diagnosis and treatment. The resected specimen was submitted for rapid pathological diagnosis during the operation, and a benign tumor, possibly sclerosing pneumocytoma, was suspected. Therefore, we completed the operation with wide wedge resection. The final histopathological diagnosis was pulmonary adenofibroma. The patient had an uneventful postoperative course, and at this writing, 6 months postoperatively, there has been no evidence of tumor recurrence. We have reported this case of pulmonary adenofibroma because the tumor is rare, has not yet been well-characterized, and has an unclear prognosis. Collection of data from a larger number of patients is necessary.

    DOI： 10.1272/jnms.JNMS.2021_88-516

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  • 各科におけるロボット支援下手術の工夫 肺癌に対する開胸術と同等の鋭的操作によるロボット手術の工夫

    臼田 実男, 井上 達哉, 竹ヶ原 京志郎, 園川 卓海, 松本 充生, 榎本 豊

    日本癌治療学会学術集会抄録集   58回   WS23 - 3   2020.10

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  • 開胸術と同じ鋭的剥離を意識したロボット支援下リンパ節郭清術の工夫

    臼田 実男, 井上 達哉, 竹ヶ原 京志郎, 園川 卓海, 松本 充生, 榎本 豊

    肺癌   60 ( 6 )   592 - 592   2020.10

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    Language：Japanese   Publisher：(NPO)日本肺癌学会  

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  • 呼吸器外科領域のロボット手術の現状と将来 開胸術と同等の鋭的剥離操作による肺癌に対するロボット支援下手術の工夫

    臼田 実男, 井上 達哉, 竹ヶ原 京志郎, 園川 卓海, 松本 充生, 榎本 豊

    日本臨床外科学会雑誌   81 ( 増刊 )   234 - 234   2020.10

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    Language：Japanese   Publisher：日本臨床外科学会  

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  • 赤芽球癆合併胸腺腫に対する治療方針の検討

    富岡 勇宇也, 竹ヶ原 京志郎, 松本 充生, 園川 卓海, 井上 達哉, 榎本 豊, 臼田 実男

    日本臨床外科学会雑誌   81 ( 増刊 )   586 - 586   2020.10

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  • オープンソースDICOM画像処理ソフトウェアHorosの術前シミュレーションおよび臨床研究への応用

    竹ヶ原 京志郎, 園川 卓海, 榎本 豊, 井上 達哉, 臼田 実男

    日本呼吸器外科学会雑誌   34 ( 3 )   O42 - 3   2020.8

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  • 小型肺腫瘍に対する画像診断の精度向上にむけた新たな検討

    園川 卓海, 竹ヶ原 京志郎, 井上 達哉, 榎本 豊, 臼田 実男

    日本呼吸器外科学会雑誌   34 ( 3 )   O7 - 6   2020.8

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  • Cushing症候群を伴ったACTH産生肺定型カルチノイドの1切除例

    園川 卓海, 竹ヶ原 京志郎, 井上 達哉, 榎本 豊, 寺崎 泰弘, 臼田 実男

    肺癌   60 ( 4 )   358 - 363   2020.8

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    Language：Japanese   Publisher：(NPO)日本肺癌学会  

    背景.肺カルチノイドは原発性肺悪性腫瘍の1〜2%を占め,稀にadrenocorticotropic hormone(ACTH)産生を伴う.症例.42歳,女性.1年前より体重増加,満月様顔貌を自覚しており,2ヵ月前からの腰背部痛を主訴に当院を受診.特徴的な身体所見や,ACTH及びコルチゾールの上昇を認め,他の内分泌学的精査と合わせてCushing症候群と診断された.胸部CTで左肺上葉に腫瘍を認め,異所性ACTH産生腫瘍が疑われたため,左上葉切除術,リンパ節郭清術を施行した.病理診断は定型カルチノイドで,大動脈下リンパ節に転移を認めた.また,免疫染色でACTHが陽性であり,ACTH産生肺定型カルチノイド,pT1bN2M0,stage IIIAと診断された.術後,ACTH及びコルチゾールは一過性に低下したが,速やかに再上昇し,高値が遷延した.術後精査でその原因を説明する所見はなく,トリロスタン投与後,切除7ヵ月後にいずれも正常範囲まで低下した.現在,術後3年であるが,再発や症状増悪は認めていない.結論.特異的な術後ホルモン濃度の推移を辿ったACTH産生肺定型カルチノイドの1例を経験した.(著者抄録)

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  • 気腫性肺嚢胞壁発生肺癌症例の臨床病理学的検討 現行のTNM分類におけるT因子は妥当か?

    竹ヶ原 京志郎, 園川 卓海, 榎本 豊, 井上 達哉, 臼田 実男

    日本呼吸器外科学会雑誌   34 ( 3 )   RO20 - 1   2020.8

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  • 中枢気道病変に対する硬性気管支鏡によるインターベンションの経験

    井上 達哉, 竹ヶ原 京志郎, 園川 卓海, 榎本 豊, 臼田 実男

    気管支学   42 ( Suppl. )   S247 - S247   2020.6

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    Language：Japanese   Publisher：(NPO)日本呼吸器内視鏡学会  

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  • ECMO管理下における中枢気道病変に対する呼吸器インターベンション

    園川 卓海, 竹ヶ原 京志郎, 井上 達哉, 榎本 豊, 臼田 実男

    気管支学   42 ( Suppl. )   S187 - S187   2020.6

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  • 気管癌による高度気道狭窄に対し、ECMO下に硬性気管支鏡下気道開大術を施行し救命し得た1例

    竹ヶ原 京志郎, 園川 卓海, 榎本 豊, 井上 達哉, 臼田 実男

    気管支学   42 ( 1 )   103 - 103   2020.1

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  • Interventional bronchoscopyの進歩と応用 新しい自家蛍光内視鏡システムを用いた呼吸器インターベンションへの応用

    園川 卓海, 松本 充生, 竹ヶ原 京志郎, 井上 達哉, 榎本 豊, 臼田 実男

    肺癌   59 ( 6 )   569 - 569   2019.11

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  • 病理病期IA期非小細胞肺癌根治切除後の再発例の臨床病理学的検討

    竹ヶ原 京志郎, 松本 充生, 園川 卓海, 井上 達哉, 榎本 豊, 臼田 実男

    肺癌   59 ( 6 )   834 - 834   2019.11

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  • 若年者肺癌(40歳以下)手術症例の検討

    榎本 豊, 松本 充生, 園川 卓海, 竹ヶ原 京志郎, 井上 達哉, 臼田 実男

    肺癌   59 ( 6 )   841 - 841   2019.11

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  • 開胸時洗浄細胞診陽性肺癌手術症例の検討

    井上 達哉, 榎本 豊, 竹ヶ原 京志郎, 園川 卓海, 松本 充生, 臼田 実男

    肺癌   59 ( 6 )   870 - 870   2019.11

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  • 赤芽球癆合併胸腺腫の一切除例

    富岡 勇宇也, 竹ヶ原 京志郎, 松本 充生, 園川 卓海, 井上 達哉, 榎本 豊, 臼田 実男

    日本胸部外科学会関東甲信越地方会要旨集   ( 181回 )   30 - 30   2019.11

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  • PDT・PDDの新応用・新技術 末梢小型肺癌に対する新しい経気管支鏡治療の開発

    臼田 実男, 井上 達哉, 竹ヶ原 京志郎, 園川 卓海, 松井 琢真, 松本 充夫, 榎本 豊

    日本レーザー医学会誌   40 ( Suppl. )   S64 - S64   2019.11

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  • 原発巣切除後遠隔期に肺転移した甲状腺乳頭癌に対する切除例

    井上 達哉, 榎本 豊, 竹ヶ原 京志郎, 園川 卓海, 松本 充生, 功刀 しのぶ, 寺崎 泰弘, 清水 章, 臼田 実男

    日本臨床外科学会雑誌   80 ( 増刊 )   606 - 606   2019.10

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  • 末梢小型肺癌に対する次世代型気管支鏡治療法の開発

    臼田 実男, 土田 敬明, 大崎 能伸, 池田 徳彦, 井上 達哉, 竹ヶ原 京志郎, 園川 卓海, 松本 充生

    日本癌治療学会学術集会抄録集   57回   RT1 - 1   2019.10

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  • 呼吸器領域におけるレーザー医療の進歩と課題 末梢肺がんに対する光線力学的治療に関する医師主導治験

    臼田 実男, 井上 達哉, 竹ヶ原 京志郎, 園川 卓海, 松本 充夫, 土田 敬明, 大崎 伸能, 池田 徳彦

    日本レーザー医学会誌   40 ( 3 )   245 - 245   2019.9

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  • 肺転移によって発見された不顕性甲状腺乳頭癌の1切除例

    井上 達哉, 竹ヶ原 京志郎, 園川 卓海, 松本 充生, 榎本 豊, 臼田 実男, 功刀 しのぶ, 寺崎 泰弘, 清水 章

    肺癌   59 ( 4 )   435 - 435   2019.8

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  • 妊娠中に発症した月経随伴性気胸の1例

    園川 卓海, 松井 琢真, 竹ヶ原 京志郎, 井上 達哉, 臼田 実男

    気管支学   41 ( 4 )   370 - 374   2019.7

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    背景.月経随伴性気胸は月経前後に発症し、妊娠中など無月経の時期には発症しないことが特徴とされている。しかし、その発生機序に関しては、未だに明確な見解は確立されていない。今回我々は、妊娠中に発症した月経随伴性気胸の1例を経験したので報告する。症例.32歳、女性。29歳時より月経時に胸痛を自覚しており、月経随伴性気胸を疑われていたが、保存的加療で軽快していた。今回は妊娠34週4日目に胸痛を自覚し、右気胸の診断となった。帝王切開にて出産した後もair leakが持続したため、胸腔鏡下手術を施行した。胸腔内を観察すると、中葉に1cm大の嚢胞、横隔膜に複数個の小孔を認めたため、右中葉部分切除術と横隔膜病変の生検、縫縮術を施行した。病理組織学的に嚢胞壁及び横隔膜の小孔周囲にエストロゲンレセプター及びプロゲステロンレセプター陽性細胞を認め、月経随伴性気胸と診断した。結論.本症例は妊娠中に気胸を発症しており、月経随伴性気胸の発生機序を考察する上で貴重な症例と考えられた。(著者抄録)

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    Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2019&ichushi_jid=J00298&link_issn=&doc_id=20190809140007&doc_link_id=%2Fcf0brond%2F2019%2F004104%2F008%2F0370-0374%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fcf0brond%2F2019%2F004104%2F008%2F0370-0374%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

  • 悪性腫瘍と感染症に対するPDTの最前線 肺癌に対する光線力学的治療(Photodynamic Therapy:PDT)

    臼田 実男, 井上 達哉, 竹ヶ原 京志郎, 園川 卓海, 松本 充夫

    日本レーザー治療学会誌   18 ( 1 )   40 - 40   2019.6

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  • Spontaneous pulmonary hematoma with diffuse pulmonary ossification requiring emergency treatment: a case report. Reviewed International journal

    Sonokawa T, Matsui T, Takegahara K, Inoue T, Kashiwada T, Terasaki Y, Usuda J

    Surgical case reports   5 ( 1 )   27 - 27   2019.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: Pulmonary hematoma is most often caused by thoracic trauma. However, rare cases of pulmonary hematoma without any obvious cause are sometimes reported, when the condition is referred to as spontaneous or idiopathic pulmonary hematoma. Herein, we report a very rare case-to the best of our knowledge, this is the first case of pulmonary hematoma associated with diffuse pulmonary ossification requiring emergency treatment reported in the English literature. CASE PRESENTATION: Our patient was a 44-year-old man with a history of IgA nephropathy and had no history of trauma or anticoagulant use. He presented with the chief complaint of bloody sputum and was referred to our hospital for detailed examination. Chest computed tomography showed a right pleural effusion and a large round mass in the right lower lobe. We performed chest tube drainage of the right thorax and confirmed bloody pleural effusion. Although bronchial artery embolization was performed, the patient's anemia worsened, and we performed right lower lobectomy. Histopathological examination of the resected specimen showed a hematoma with diffuse pulmonary ossification, although the relationship between the two was unclear. There was no evidence of malignancy or angiitis. Therefore, we made the diagnosis of spontaneous pulmonary hematoma in this case. The postoperative course was uneventful. The patient is currently under observation as an outpatient, and a recent chest X-ray showed no evidence of recurrence. CONCLUSION: We report a case of spontaneous pulmonary hematoma with diffuse pulmonary ossification. Although the relationship between the two remains unclear, considering the possibility of appearance of new lesions/recurrence, we believe that careful follow-up is necessary for this patient.

    DOI： 10.1186/s40792-019-0589-6

    PubMed

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  • 末梢型肺癌に対する光線力学的治療(PDT)の開発

    臼田 実男, 井上 達哉, 竹ヶ原 京志郎, 園川 卓海, 松井 琢真, 松本 充, 土田 敬明, 池田 徳彦, 大崎 能伸

    気管支学   41 ( 1 )   92 - 92   2019.1

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  • 多発性気管乳頭腫に対して硬性気管支鏡下腫瘍摘出を施行した１例

    園川卓海, 竹ヶ原京志郎, 井上達哉, 臼田実男

    気管支学   40 ( 4 )   357 - 360   2018.7

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  • 肋骨原発動脈瘤様骨嚢腫の1切除例

    竹ヶ原 京志郎, 園川 卓海, 松井 琢真, 井上 達哉, 臼田 実男

    日本胸部外科学会関東甲信越地方会要旨集   ( 177回 )   24 - 24   2018.6

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  • 呼吸器内視鏡における新技術 末梢小型肺癌に対する新しい経気管支鏡治療の開発

    臼田 実男, 井上 達哉, 竹ヶ原 京志郎, 園川 卓海, 松井 琢真, 松本 充, 土田 敬明, 池田 徳彦, 大崎 能伸

    気管支学   40 ( Suppl. )   S164 - S164   2018.5

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  • 早期診断し得た気管・気管支原発MALTリンパ腫の１例

    竹ヶ原京志郎, 吉野直之, 園川卓海, 井上達哉, 臼田実男

    気管支学   40 ( 3 )   221 - 225   2018.5

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  • 気道狭窄に対する呼吸器インターベンション治療 当科の治療指針

    竹ヶ原 京志郎, 園川 卓海, 井上 達哉, 臼田 実男

    気管支学   40 ( Suppl. )   S187 - S187   2018.5

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  • 当院での気道インターベンションの経験

    井上 達哉, 竹ヶ原 京志郎, 園川 卓海, 松井 琢真, 臼田 実男

    気管支学   40 ( Suppl. )   S188 - S188   2018.5

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  • 3次元画像解析システムSYNAPSE VINCENTを用いた術前シミュレーション 若手呼吸器外科医の視点から

    竹ヶ原 京志郎, 園川 卓海, 松井 琢真, 井上 達哉, 臼田 実男

    気管支学   40 ( Suppl. )   S190 - S190   2018.5

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  • 多発肺癌に対する治療戦略 肺切除術+PDT

    園川 卓海, 松井 琢真, 竹ヶ原 京志郎, 井上 達哉, 臼田 実男

    気管支学   40 ( Suppl. )   S205 - S205   2018.5

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  • アンチエイジング遺伝子Klotho発現に基づく新たな肺癌個別化治療法の確立

    竹ヶ原 京志郎, 園川 卓海, 井上 達哉, 臼田 実男

    日本呼吸器外科学会雑誌   32 ( 3 )   O19 - 4   2018.4

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  • Anti-aging遺伝子Klotho発現に基づく新しい肺癌個別化治療

    竹ヶ原 京志郎, 園川 卓海, 井上 達哉, 臼田 実男

    日本外科学会定期学術集会抄録集   118回   1263 - 1263   2018.4

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  • 嚢胞壁に発生した大細胞神経内分泌癌(LCNEC)の1切除例

    園川 卓海, 松井 琢真, 竹ヶ原 京志郎, 井上 達哉, 臼田 実男

    肺癌   58 ( 2 )   170 - 170   2018.4

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  • 間質性肺炎合併肺癌に対する外科治療戦略

    臼田 実男, 井上 達哉, 竹ヶ原 京志郎, 園川 卓海, 松井 琢真

    日本呼吸器外科学会雑誌   32 ( 3 )   O10 - 1   2018.4

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  • 急速に増大した縦隔脂肪肉腫の1切除例

    竹ヶ原 京志郎, 園川 卓海, 井上 達哉, 臼田 実男

    日本胸部外科学会関東甲信越地方会要旨集   ( 176回 )   19 - 19   2018.3

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  • 間質性肺炎合併同時性多発肺癌に対し、手術及びPDTを施行した1例

    竹ヶ原 京志郎, 園川 卓海, 井上 達哉, 臼田 実男

    気管支学   40 ( 1 )   86 - 86   2018.1

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  • 膿胸による喀血に対してECMO導入下に左肺全摘術を施行し救命した一例

    園川 卓海, 竹ヶ原 京志郎, 井上 達哉, 臼田 実男

    日本胸部外科学会関東甲信越地方会要旨集   ( 175回 )   19 - 19   2017.11

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  • 呼吸器疾患に対する最新のレーザー治療 末梢肺癌に対するPDT

    井上 達哉, 竹ヶ原 京志郎, 園川 卓海, 大崎 能伸, 土田 敬明, 池田 徳彦, 臼田 実男

    日本レーザー医学会誌   38 ( 3 )   253 - 253   2017.10

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  • 呼吸器疾患に対する最新のレーザー治療 進行肺癌に対するレーザー治療 高出力レーザーVS PDT

    竹ヶ原 京志郎, 井上 達哉, 園川 卓海, 臼田 実男

    日本レーザー医学会誌   38 ( 3 )   254 - 254   2017.10

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  • [Complete Surgical Resection for Lung Cancer Invading Anterior Apex after Preoperative Chemoradiotherapy Via Transmanubrial Approach and Anterolateral Thoracotomy]. Reviewed

    Inoue T, Takegahara K, Sonokawa T, Usuda J

    Kyobu geka. The Japanese journal of thoracic surgery   70 ( 11 )   910 - 914   2017.10

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  • 新しいCOPD合併肺癌の周術期治療戦略

    竹ヶ原 京志郎, 園川 卓海, 井上 達哉, 臼田 実男

    日本臨床外科学会雑誌   78 ( 増刊 )   525 - 525   2017.10

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  • 肺化膿症で左下葉切除術後、喀血に対してECMO導入のもと左肺全摘術を施行して救命した一例

    園川 卓海, 竹ヶ原 京志郎, 井上 達哉, 臼田 実男

    日本臨床外科学会雑誌   78 ( 増刊 )   771 - 771   2017.10

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  • 多発性気管乳頭腫に対して内視鏡的治療を施行した1例

    園川 卓海, 竹ヶ原 京志郎, 井上 達哉, 臼田 実男

    気管支学   39 ( 5 )   459 - 459   2017.9

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  • アンチエイジング遺伝子Klotho発現による上皮間葉転換(EMT)の制御

    竹ヶ原 京志郎, 園川 卓海, 井上 達哉, 臼田 実男

    肺癌   57 ( 5 )   626 - 626   2017.9

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Misc.

Research Projects

  • Development of a Novel Photodynamic Immunotherapy for Solid Cancer

    Grant number：22K07310  2022.4 - 2025.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Grant amount：\3250000 （ Direct Cost: \2500000 、 Indirect Cost：\750000 ）

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