2024/04/11 更新

写真a

サイトウ　ツネノリ
齋藤　恒徳
Saito Tsunenori
所属
多摩永山病院 救急・総合診療センター 助教
職名
助教
ホームページ
https://nrid.nii.ac.jp/ja/nrid/1000000716631/
プロフィール

培養心筋細胞を使って、ミトコンドリア選択的オートファジー（マイトファジー）の分子機序を解析しています。

心不全、心筋症が専門です。電子顕微鏡を用いた研究、心筋におけるオートファジー、エクソーム解析を用いた心筋症の関連遺伝子と超微形態との比較などを行っていました。それらの不確実性を埋めるために、分子生物学の手法を用いて毎日楽しく実験しています。

複雑な病気やメカニズムも、実際に見えるようにしてみると随分わかりやすくなるようです。Alles Große ist einfach（すべて偉大なものは単純である。Wilhelm Furtwängler, 『音と言葉』）。

 

 

外部リンク

学位

  • 医学博士 （ 2012年3月   日本医科大学 ）

研究キーワード

  • 電子顕微鏡

  • 全エクソーム解析

  • 心不全

  • ミトコンドリア選択的オートファジー

  • 拡張型心筋症

  • オートファジー

研究分野

  • ライフサイエンス / 医化学  / オートファジー

  • ライフサイエンス / 医化学

  • ライフサイエンス / 人体病理学  / 心血管病理

  • ライフサイエンス / 循環器内科学

学歴

  • 日本医科大学大学院   医学研究科   器官機能病態内科学部門

    2008年4月 - 2012年3月

    　 詳細を見る

  • 日本医科大学   医学部   医学科

    2000年4月 - 2006年3月

    　 詳細を見る

経歴

  • 日本医科大学多摩永山病院   循環器内科   助教

    2021年6月 - 現在

    　 詳細を見る

    国名：日本国

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  • Cedars-Sinai Medical Center   Smidt Heart Institute   Visiting Postdoctoral Scientist

    2019年7月 - 2021年5月

    　 詳細を見る

    国名：アメリカ合衆国

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  • 日本医科大学多摩永山病院   内科・循環器内科   助教

    2013年5月 - 2019年6月

    　 詳細を見る

  • 北村山公立病院   内科   医長

    2013年4月

    　 詳細を見る

  • 北村山公立病院   内科   医員

    2012年4月 - 2013年3月

    　 詳細を見る

  • 日本医科大学大学院   器官機能病態内科学部門（第一内科）   大学院生・専修医

    2008年4月 - 2012年3月

    　 詳細を見る

  • 国家公務員共済組合 虎の門病院   内科   前期研修医

    2006年4月 - 2008年3月

    　 詳細を見る

▼全件表示

所属学協会

▼全件表示

委員歴

  • 日本内科学会   内科指導医  

    2021年6月 - 現在   

    　 詳細を見る

    団体区分：学協会

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  • American College of Cardiology   FACC  

    2021年1月 - 現在   

    　 詳細を見る

    団体区分：学協会

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  • 日本心血管インターベンション学会   認定医  

    2018年10月 - 現在   

    　 詳細を見る

    団体区分：学協会

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  • American College of Physicians   FACP  

    2017年5月 - 現在   

    　 詳細を見る

    団体区分：学協会

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  • European Society of Cardiology   Working Group on Myocardial and Pericardial Diseases  

    2015年9月 - 現在   

    　 詳細を見る

    団体区分：学協会

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  • 心筋生検研究会   学術企画委員  

    2014年10月 - 現在   

    　 詳細を見る

    団体区分：学協会

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  • 心筋生検研究会   幹事（評議員）  

    2014年10月 - 現在   

    　 詳細を見る

    団体区分：学協会

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  • 日本循環器学会   循環器専門医  

    2014年4月 - 現在   

    　 詳細を見る

    団体区分：学協会

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  • 日本内科学会   総合内科専門医  

    2012年12月 - 現在   

    　 詳細を見る

    団体区分：学協会

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  • American Heart Association   FAHA  

    2011年11月 - 現在   

    　 詳細を見る

    団体区分：学協会

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  • 日本内科学会   認定内科医  

    2009年9月 - 現在   

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    団体区分：学協会

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▼全件表示

論文

  • Histological validation of atrial structural remodelling in patients with atrial fibrillation. 国際誌

    Yuya Takahashi, Takanori Yamaguchi, Toyokazu Otsubo, Kana Nakashima, Kodai Shinzato, Ryosuke Osako, Shigeki Shichida, Yuki Kawano, Akira Fukui, Atsushi Kawaguchi, Shinichi Aishima, Tsunenori Saito, Naohiko Takahashi, Koichi Node

    European heart journal   2023年6月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    BACKGROUND AND AIMS: This study aimed to histologically validate atrial structural remodelling associated with atrial fibrillation. METHODS AND RESULTS: Patients undergoing atrial fibrillation ablation and endomyocardial atrial biopsy were included (n = 230; 67 ± 12 years old; 69 women). Electroanatomic mapping was performed during right atrial pacing. Voltage at the biopsy site (Vbiopsy), global left atrial voltage (VGLA), and the proportion of points with fractionated electrograms defined as ≥5 deflections in each electrogram (%Fractionated EGM) were evaluated. SCZtotal was calculated as the total width of slow conduction zones, defined as regions with a conduction velocity of <30 cm/s. Histological factors potentially associated with electroanatomic characteristics were evaluated using multiple linear regression analyses. Ultrastructural features and immune cell infiltration were evaluated by electron microscopy and immunohistochemical staining in 33 and 60 patients, respectively. Fibrosis, intercellular space, myofibrillar loss, and myocardial nuclear density were significantly associated with Vbiopsy (P = .014, P < .001, P < .001, and P = .002, respectively) and VGLA (P = .010, P < .001, P = .001, and P < .001, respectively). The intercellular space was associated with the %Fractionated EGM (P = .001). Fibrosis, intercellular space, and myofibrillar loss were associated with SCZtotal (P = .028, P < .001, and P = .015, respectively). Electron microscopy confirmed plasma components and immature collagen fibrils in the increased intercellular space and myofilament lysis in cardiomyocytes, depending on myofibrillar loss. Among the histological factors, the severity of myofibrillar loss was associated with an increase in macrophage infiltration. CONCLUSION: Histological correlates of atrial structural remodelling were fibrosis, increased intercellular space, myofibrillar loss, and decreased nuclear density. Each histological component was defined using electron microscopy and immunohistochemistry studies.

    DOI： 10.1093/eurheartj/ehad396

    PubMed

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  • Myocardial ultrastructure can augment genetic testing for sporadic dilated cardiomyopathy with initial heart failure. 国際誌

    Tsunenori Saito, Naoko Saito Sato, Kosuke Mozawa, Akiko Adachi, Yoshihiro Sasaki, Kotoka Nakamura, Eiichiro Oka, Toshiaki Otsuka, Eitaro Kodani, Kuniya Asai, Kyoichi Mizuno, Wataru Shimizu, Roberta A Gottlieb

    ESC heart failure   8 ( 6 )   5178 - 5191   2021年9月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    AIMS: The aim of the present study was to consider whether the ultrastructural features of cardiomyocytes in dilated cardiomyopathy can be used to guide genetic testing. METHODS AND RESULTS: Endomyocardial biopsy and whole-exome sequencing were performed in 32 consecutive sporadic dilated cardiomyopathy patients [51.0 (40.0-64.0) years, 75% men] in initial phases of decompensated heart failure. The predicted pathogenicity of ultrarare (minor allele frequency ≤0.0005), non-synonymous variants was determined using the American College of Medical Genetics guidelines. Focusing on 75 cardiomyopathy-susceptibility and 41 arrhythmia-susceptibility genes, we identified 404 gene variants, of which 15 were considered pathogenic or likely pathogenic in 14 patients (44% of 32). There were five sarcomeric gene variants (29% of 17 variants) found in five patients (16% of 32), involving a variant of MYBPC3 and four variants of TTN. A patient with an MYBPC3 variant showed disorganized sarcomeres, three patients with TTN variants located in the region encoding the A-band domain showed sparse sarcomeres, and a patient with a TTN variant in encoding the I-band domain showed disrupted sarcomeres. The distribution of diffuse myofilament lysis depended on the causal genes; three patients with the same TMEM43 variant had diffuse myofilament lysis near nuclei (P = 0.011), while two patients with different DSP variants had lysis in the peripheral areas of cardiomyocytes (P = 0.033). CONCLUSIONS: Derangement patterns of myofilament and subcellular distribution of myofilament lysis might implicate causal genes. Large-scale studies are required to confirm whether these ultrastructural findings are related to the causative genes.

    DOI： 10.1002/ehf2.13596

    PubMed

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  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1. 国際誌

    Daniel J Klionsky, Amal Kamal Abdel-Aziz, Sara Abdelfatah, Mahmoud Abdellatif, Asghar Abdoli, Steffen Abel, Hagai Abeliovich, Marie H Abildgaard, Yakubu Princely Abudu, Abraham Acevedo-Arozena, Iannis E Adamopoulos, Khosrow Adeli, Timon E Adolph, Annagrazia Adornetto, Elma Aflaki, Galila Agam, Anupam Agarwal, Bharat B Aggarwal, Maria Agnello, Patrizia Agostinis, Javed N Agrewala, Alexander Agrotis, Patricia V Aguilar, S Tariq Ahmad, Zubair M Ahmed, Ulises Ahumada-Castro, Sonja Aits, Shu Aizawa, Yunus Akkoc, Tonia Akoumianaki, Hafize Aysin Akpinar, Ahmed M Al-Abd, Lina Al-Akra, Abeer Al-Gharaibeh, Moulay A Alaoui-Jamali, Simon Alberti, Elísabet Alcocer-Gómez, Cristiano Alessandri, Muhammad Ali, M Abdul Alim Al-Bari, Saeb Aliwaini, Javad Alizadeh, Eugènia Almacellas, Alexandru Almasan, Alicia Alonso, Guillermo D Alonso, Nihal Altan-Bonnet, Dario C Altieri, Élida M C Álvarez, Sara Alves, Cristine Alves da Costa, Mazen M Alzaharna, Marialaura Amadio, Consuelo Amantini, Cristina Amaral, Susanna Ambrosio, Amal O Amer, Veena Ammanathan, Zhenyi An, Stig U Andersen, Shaida A Andrabi, Magaiver Andrade-Silva, Allen M Andres, Sabrina Angelini, David Ann, Uche C Anozie, Mohammad Y Ansari, Pedro Antas, Adam Antebi, Zuriñe Antón, Tahira Anwar, Lionel Apetoh, Nadezda Apostolova, Toshiyuki Araki, Yasuhiro Araki, Kohei Arasaki, Wagner L Araújo, Jun Araya, Catherine Arden, Maria-Angeles Arévalo, Sandro Arguelles, Esperanza Arias, Jyothi Arikkath, Hirokazu Arimoto, Aileen R Ariosa, Darius Armstrong-James, Laetitia Arnauné-Pelloquin, Angeles Aroca, Daniela S Arroyo, Ivica Arsov, Rubén Artero, Dalia Maria Lucia Asaro, Michael Aschner, Milad Ashrafizadeh, Osnat Ashur-Fabian, Atanas G Atanasov, Alicia K Au, Patrick Auberger, Holger W Auner, Laure Aurelian, Riccardo Autelli, Laura Avagliano, Yenniffer Ávalos, Sanja Aveic, Célia Alexandra Aveleira, Tamar Avin-Wittenberg, Yucel Aydin, Scott Ayton, Srinivas Ayyadevara, Maria Azzopardi, Misuzu Baba, Jonathan M Backer, Steven K Backues, Dong-Hun Bae, Ok-Nam Bae, Soo Han Bae, Eric H Baehrecke, Ahruem Baek, Seung-Hoon Baek, Sung Hee Baek, Giacinto Bagetta, Agnieszka Bagniewska-Zadworna, Hua Bai, Jie Bai, Xiyuan Bai, Yidong Bai, Nandadulal Bairagi, Shounak Baksi, Teresa Balbi, Cosima T Baldari, Walter Balduini, Andrea Ballabio, Maria Ballester, Salma Balazadeh, Rena Balzan, Rina Bandopadhyay, Sreeparna Banerjee, Sulagna Banerjee, Ágnes Bánréti, Yan Bao, Mauricio S Baptista, Alessandra Baracca, Cristiana Barbati, Ariadna Bargiela, Daniela Barilà, Peter G Barlow, Sami J Barmada, Esther Barreiro, George E Barreto, Jiri Bartek, Bonnie Bartel, Alberto Bartolome, Gaurav R Barve, Suresh H Basagoudanavar, Diane C Bassham, Robert C Bast Jr, Alakananda Basu, Henri Batoko, Isabella Batten, Etienne E Baulieu, Bradley L Baumgarner, Jagadeesh Bayry, Rupert Beale, Isabelle Beau, Florian Beaumatin, Luiz R G Bechara, George R Beck Jr, Michael F Beers, Jakob Begun, Christian Behrends, Georg M N Behrens, Roberto Bei, Eloy Bejarano, Shai Bel, Christian Behl, Amine Belaid, Naïma Belgareh-Touzé, Cristina Bellarosa, Francesca Belleudi, Melissa Belló Pérez, Raquel Bello-Morales, Jackeline Soares de Oliveira Beltran, Sebastián Beltran, Doris Mangiaracina Benbrook, Mykolas Bendorius, Bruno A Benitez, Irene Benito-Cuesta, Julien Bensalem, Martin W Berchtold, Sabina Berezowska, Daniele Bergamaschi, Matteo Bergami, Andreas Bergmann, Laura Berliocchi, Clarisse Berlioz-Torrent, Amélie Bernard, Lionel Berthoux, Cagri G Besirli, Sebastien Besteiro, Virginie M Betin, Rudi Beyaert, Jelena S Bezbradica, Kiran Bhaskar, Ingrid Bhatia-Kissova, Resham Bhattacharya, Sujoy Bhattacharya, Shalmoli Bhattacharyya, Md Shenuarin Bhuiyan, Sujit Kumar Bhutia, Lanrong Bi, Xiaolin Bi, Trevor J Biden, Krikor Bijian, Viktor A Billes, Nadine Binart, Claudia Bincoletto, Asa B Birgisdottir, Geir Bjorkoy, Gonzalo Blanco, Ana Blas-Garcia, Janusz Blasiak, Robert Blomgran, Klas Blomgren, Janice S Blum, Emilio Boada-Romero, Mirta Boban, Kathleen Boesze-Battaglia, Philippe Boeuf, Barry Boland, Pascale Bomont, Paolo Bonaldo, Srinivasa Reddy Bonam, Laura Bonfili, Juan S Bonifacino, Brian A Boone, Martin D Bootman, Matteo Bordi, Christoph Borner, Beat C Bornhauser, Gautam Borthakur, Jürgen Bosch, Santanu Bose, Luis M Botana, Juan Botas, Chantal M Boulanger, Michael E Boulton, Mathieu Bourdenx, Benjamin Bourgeois, Nollaig M Bourke, Guilhem Bousquet, Patricia Boya, Peter V Bozhkov, Luiz H M Bozi, Tolga O Bozkurt, Doug E Brackney, Christian H Brandts, Ralf J Braun, Gerhard H Braus, Roberto Bravo-Sagua, José M Bravo-San Pedro, Patrick Brest, Marie-Agnès Bringer, Alfredo Briones-Herrera, V Courtney Broaddus, Peter Brodersen, Jeffrey L Brodsky, Steven L Brody, Paola G Bronson, Jeff M Bronstein, Carolyn N Brown, Rhoderick E Brown, Patricia C Brum, John H Brumell, Nicola Brunetti-Pierri, Daniele Bruno, Robert J Bryson-Richardson, Cecilia Bucci, Carmen Buchrieser, Marta Bueno, Laura Elisa Buitrago-Molina, Simone Buraschi, Shilpa Buch, J Ross Buchan, Erin M Buckingham, Hikmet Budak, Mauricio Budini, Geert Bultynck, Florin Burada, Joseph R Burgoyne, M Isabel Burón, Victor Bustos, Sabrina Büttner, Elena Butturini, Aaron Byrd, Isabel Cabas, Sandra Cabrera-Benitez, Ken Cadwell, Jingjing Cai, Lu Cai, Qian Cai, Montserrat Cairó, Jose A Calbet, Guy A Caldwell, Kim A Caldwell, Jarrod A Call, Riccardo Calvani, Ana C Calvo, Miguel Calvo-Rubio Barrera, Niels Os Camara, Jacques H Camonis, Nadine Camougrand, Michelangelo Campanella, Edward M Campbell, François-Xavier Campbell-Valois, Silvia Campello, Ilaria Campesi, Juliane C Campos, Olivier Camuzard, Jorge Cancino, Danilo Candido de Almeida, Laura Canesi, Isabella Caniggia, Barbara Canonico, Carles Cantí, Bin Cao, Michele Caraglia, Beatriz Caramés, Evie H Carchman, Elena Cardenal-Muñoz, Cesar Cardenas, Luis Cardenas, Sandra M Cardoso, Jennifer S Carew, Georges F Carle, Gillian Carleton, Silvia Carloni, Didac Carmona-Gutierrez, Leticia A Carneiro, Oliana Carnevali, Julian M Carosi, Serena Carra, Alice Carrier, Lucie Carrier, Bernadette Carroll, A Brent Carter, Andreia Neves Carvalho, Magali Casanova, Caty Casas, Josefina Casas, Chiara Cassioli, Eliseo F Castillo, Karen Castillo, Sonia Castillo-Lluva, Francesca Castoldi, Marco Castori, Ariel F Castro, Margarida Castro-Caldas, Javier Castro-Hernandez, Susana Castro-Obregon, Sergio D Catz, Claudia Cavadas, Federica Cavaliere, Gabriella Cavallini, Maria Cavinato, Maria L Cayuela, Paula Cebollada Rica, Valentina Cecarini, Francesco Cecconi, Marzanna Cechowska-Pasko, Simone Cenci, Victòria Ceperuelo-Mallafré, João J Cerqueira, Janete M Cerutti, Davide Cervia, Vildan Bozok Cetintas, Silvia Cetrullo, Han-Jung Chae, Andrei S Chagin, Chee-Yin Chai, Gopal Chakrabarti, Oishee Chakrabarti, Tapas Chakraborty, Trinad Chakraborty, Mounia Chami, Georgios Chamilos, David W Chan, Edmond Y W Chan, Edward D Chan, H Y Edwin Chan, Helen H Chan, Hung Chan, Matthew T V Chan, Yau Sang Chan, Partha K Chandra, Chih-Peng Chang, Chunmei Chang, Hao-Chun Chang, Kai Chang, Jie Chao, Tracey Chapman, Nicolas Charlet-Berguerand, Samrat Chatterjee, Shail K Chaube, Anu Chaudhary, Santosh Chauhan, Edward Chaum, Frédéric Checler, Michael E Cheetham, Chang-Shi Chen, Guang-Chao Chen, Jian-Fu Chen, Liam L Chen, Leilei Chen, Lin Chen, Mingliang Chen, Mu-Kuan Chen, Ning Chen, Quan Chen, Ruey-Hwa Chen, Shi Chen, Wei Chen, Weiqiang Chen, Xin-Ming Chen, Xiong-Wen Chen, Xu Chen, Yan Chen, Ye-Guang Chen, Yingyu Chen, Yongqiang Chen, Yu-Jen Chen, Yue-Qin Chen, Zhefan Stephen Chen, Zhi Chen, Zhi-Hua Chen, Zhijian J Chen, Zhixiang Chen, Hanhua Cheng, Jun Cheng, Shi-Yuan Cheng, Wei Cheng, Xiaodong Cheng, Xiu-Tang Cheng, Yiyun Cheng, Zhiyong Cheng, Zhong Chen, Heesun Cheong, Jit Kong Cheong, Boris V Chernyak, Sara Cherry, Chi Fai Randy Cheung, Chun Hei Antonio Cheung, King-Ho Cheung, Eric Chevet, Richard J Chi, Alan Kwok Shing Chiang, Ferdinando Chiaradonna, Roberto Chiarelli, Mario Chiariello, Nathalia Chica, Susanna Chiocca, Mario Chiong, Shih-Hwa Chiou, Abhilash I Chiramel, Valerio Chiurchiù, Dong-Hyung Cho, Seong-Kyu Choe, Augustine M K Choi, Mary E Choi, Kamalika Roy Choudhury, Norman S Chow, Charleen T Chu, Jason P Chua, John Jia En Chua, Hyewon Chung, Kin Pan Chung, Seockhoon Chung, So-Hyang Chung, Yuen-Li Chung, Valentina Cianfanelli, Iwona A Ciechomska, Mariana Cifuentes, Laura Cinque, Sebahattin Cirak, Mara Cirone, Michael J Clague, Robert Clarke, Emilio Clementi, Eliana M Coccia, Patrice Codogno, Ehud Cohen, Mickael M Cohen, Tania Colasanti, Fiorella Colasuonno, Robert A Colbert, Anna Colell, Miodrag Čolić, Nuria S Coll, Mark O Collins, María I Colombo, Daniel A Colón-Ramos, Lydie Combaret, Sergio Comincini, Márcia R Cominetti, Antonella Consiglio, Andrea Conte, Fabrizio Conti, Viorica Raluca Contu, Mark R Cookson, Kevin M Coombs, Isabelle Coppens, Maria Tiziana Corasaniti, Dale P Corkery, Nils Cordes, Katia Cortese, Maria do Carmo Costa, Sarah Costantino, Paola Costelli, Ana Coto-Montes, Peter J Crack, Jose L Crespo, Alfredo Criollo, Valeria Crippa, Riccardo Cristofani, Tamas Csizmadia, Antonio Cuadrado, Bing Cui, Jun Cui, Yixian Cui, Yong Cui, Emmanuel Culetto, Andrea C Cumino, Andrey V Cybulsky, Mark J Czaja, Stanislaw J Czuczwar, Stefania D'Adamo, Marcello D'Amelio, Daniela D'Arcangelo, Andrew C D'Lugos, Gabriella D'Orazi, James A da Silva, Hormos Salimi Dafsari, Ruben K Dagda, Yasin Dagdas, Maria Daglia, Xiaoxia Dai, Yun Dai, Yuyuan Dai, Jessica Dal Col, Paul Dalhaimer, Luisa Dalla Valle, Tobias Dallenga, Guillaume Dalmasso, Markus Damme, Ilaria Dando, Nico P Dantuma, April L Darling, Hiranmoy Das, Srinivasan Dasarathy, Santosh K Dasari, Srikanta Dash, Oliver Daumke, Adrian N Dauphinee, Jeffrey S Davies, Valeria A Dávila, Roger J Davis, Tanja Davis, Sharadha Dayalan Naidu, Francesca De Amicis, Karolien De Bosscher, Francesca De Felice, Lucia De Franceschi, Chiara De Leonibus, Mayara G de Mattos Barbosa, Guido R Y De Meyer, Angelo De Milito, Cosimo De Nunzio, Clara De Palma, Mauro De Santi, Claudio De Virgilio, Daniela De Zio, Jayanta Debnath, Brian J DeBosch, Jean-Paul Decuypere, Mark A Deehan, Gianluca Deflorian, James DeGregori, Benjamin Dehay, Gabriel Del Rio, Joe R Delaney, Lea M D Delbridge, Elizabeth Delorme-Axford, M Victoria Delpino, Francesca Demarchi, Vilma Dembitz, Nicholas D Demers, Hongbin Deng, Zhiqiang Deng, Joern Dengjel, Paul Dent, Donna Denton, Melvin L DePamphilis, Channing J Der, Vojo Deretic, Albert Descoteaux, Laura Devis, Sushil Devkota, Olivier Devuyst, Grant Dewson, Mahendiran Dharmasivam, Rohan Dhiman, Diego di Bernardo, Manlio Di Cristina, Fabio Di Domenico, Pietro Di Fazio, Alessio Di Fonzo, Giovanni Di Guardo, Gianni M Di Guglielmo, Luca Di Leo, Chiara Di Malta, Alessia Di Nardo, Martina Di Rienzo, Federica Di Sano, George Diallinas, Jiajie Diao, Guillermo Diaz-Araya, Inés Díaz-Laviada, Jared M Dickinson, Marc Diederich, Mélanie Dieudé, Ivan Dikic, Shiping Ding, Wen-Xing Ding, Luciana Dini, Jelena Dinić, Miroslav Dinic, Albena T Dinkova-Kostova, Marc S Dionne, Jörg H W Distler, Abhinav Diwan, Ian M C Dixon, Mojgan Djavaheri-Mergny, Ina Dobrinski, Oxana Dobrovinskaya, Radek Dobrowolski, Renwick C J Dobson, Jelena Đokić, Serap Dokmeci Emre, Massimo Donadelli, Bo Dong, Xiaonan Dong, Zhiwu Dong, Gerald W Dorn Ii, Volker Dotsch, Huan Dou, Juan Dou, Moataz Dowaidar, Sami Dridi, Liat Drucker, Ailian Du, Caigan Du, Guangwei Du, Hai-Ning Du, Li-Lin Du, André du Toit, Shao-Bin Duan, Xiaoqiong Duan, Sónia P Duarte, Anna Dubrovska, Elaine A Dunlop, Nicolas Dupont, Raúl V Durán, Bilikere S Dwarakanath, Sergey A Dyshlovoy, Darius Ebrahimi-Fakhari, Leopold Eckhart, Charles L Edelstein, Thomas Efferth, Eftekhar Eftekharpour, Ludwig Eichinger, Nabil Eid, Tobias Eisenberg, N Tony Eissa, Sanaa Eissa, Miriam Ejarque, Abdeljabar El Andaloussi, Nazira El-Hage, Shahenda El-Naggar, Anna Maria Eleuteri, Eman S El-Shafey, Mohamed Elgendy, Aristides G Eliopoulos, María M Elizalde, Philip M Elks, Hans-Peter Elsasser, Eslam S Elsherbiny, Brooke M Emerling, N C Tolga Emre, Christina H Eng, Nikolai Engedal, Anna-Mart Engelbrecht, Agnete S T Engelsen, Jorrit M Enserink, Ricardo Escalante, Audrey Esclatine, Mafalda Escobar-Henriques, Eeva-Liisa Eskelinen, Lucile Espert, Makandjou-Ola Eusebio, Gemma Fabrias, Cinzia Fabrizi, Antonio Facchiano, Francesco Facchiano, Bengt Fadeel, Claudio Fader, Alex C Faesen, W Douglas Fairlie, Alberto Falcó, Bjorn H Falkenburger, Daping Fan, Jie Fan, Yanbo Fan, Evandro F Fang, Yanshan Fang, Yognqi Fang, Manolis Fanto, Tamar Farfel-Becker, Mathias Faure, Gholamreza Fazeli, Anthony O Fedele, Arthur M Feldman, Du Feng, Jiachun Feng, Lifeng Feng, Yibin Feng, Yuchen Feng, Wei Feng, Thais Fenz Araujo, Thomas A Ferguson, Álvaro F Fernández, Jose C Fernandez-Checa, Sonia Fernández-Veledo, Alisdair R Fernie, Anthony W Ferrante Jr, Alessandra Ferraresi, Merari F Ferrari, Julio C B Ferreira, Susan Ferro-Novick, Antonio Figueras, Riccardo Filadi, Nicoletta Filigheddu, Eduardo Filippi-Chiela, Giuseppe Filomeni, Gian Maria Fimia, Vittorio Fineschi, Francesca Finetti, Steven Finkbeiner, Edward A Fisher, Paul B Fisher, Flavio Flamigni, Steven J Fliesler, Trude H Flo, Ida Florance, Oliver Florey, Tullio Florio, Erika Fodor, Carlo Follo, Edward A Fon, Antonella Forlino, Francesco Fornai, Paola Fortini, Anna Fracassi, Alessandro Fraldi, Brunella Franco, Rodrigo Franco, Flavia Franconi, Lisa B Frankel, Scott L Friedman, Leopold F Fröhlich, Gema Frühbeck, Jose M Fuentes, Yukio Fujiki, Naonobu Fujita, Yuuki Fujiwara, Mitsunori Fukuda, Simone Fulda, Luc Furic, Norihiko Furuya, Carmela Fusco, Michaela U Gack, Lidia Gaffke, Sehamuddin Galadari, Alessia Galasso, Maria F Galindo, Sachith Gallolu Kankanamalage, Lorenzo Galluzzi, Vincent Galy, Noor Gammoh, Boyi Gan, Ian G Ganley, Feng Gao, Hui Gao, Minghui Gao, Ping Gao, Shou-Jiang Gao, Wentao Gao, Xiaobo Gao, Ana Garcera, Maria Noé Garcia, Verónica E Garcia, Francisco García-Del Portillo, Vega Garcia-Escudero, Aracely Garcia-Garcia, Marina Garcia-Macia, Diana García-Moreno, Carmen Garcia-Ruiz, Patricia García-Sanz, Abhishek D Garg, Ricardo Gargini, Tina Garofalo, Robert F Garry, Nils C Gassen, Damian Gatica, Liang Ge, Wanzhong Ge, Ruth Geiss-Friedlander, Cecilia Gelfi, Pascal Genschik, Ian E Gentle, Valeria Gerbino, Christoph Gerhardt, Kyla Germain, Marc Germain, David A Gewirtz, Elham Ghasemipour Afshar, Saeid Ghavami, Alessandra Ghigo, Manosij Ghosh, Georgios Giamas, Claudia Giampietri, Alexandra Giatromanolaki, Gary E Gibson, Spencer B Gibson, Vanessa Ginet, Edward Giniger, Carlotta Giorgi, Henrique Girao, Stephen E Girardin, Mridhula Giridharan, Sandy Giuliano, Cecilia Giulivi, Sylvie Giuriato, Julien Giustiniani, Alexander Gluschko, Veit Goder, Alexander Goginashvili, Jakub Golab, David C Goldstone, Anna Golebiewska, Luciana R Gomes, Rodrigo Gomez, Rubén Gómez-Sánchez, Maria Catalina Gomez-Puerto, Raquel Gomez-Sintes, Qingqiu Gong, Felix M Goni, Javier González-Gallego, Tomas Gonzalez-Hernandez, Rosa A Gonzalez-Polo, Jose A Gonzalez-Reyes, Patricia González-Rodríguez, Ing Swie Goping, Marina S Gorbatyuk, Nikolai V Gorbunov, Kıvanç Görgülü, Roxana M Gorojod, Sharon M Gorski, Sandro Goruppi, Cecilia Gotor, Roberta A Gottlieb, Illana Gozes, Devrim Gozuacik, Martin Graef, Markus H Gräler, Veronica Granatiero, Daniel Grasso, Joshua P Gray, Douglas R Green, Alexander Greenhough, Stephen L Gregory, Edward F Griffin, Mark W Grinstaff, Frederic Gros, Charles Grose, Angelina S Gross, Florian Gruber, Paolo Grumati, Tilman Grune, Xueyan Gu, Jun-Lin Guan, Carlos M Guardia, Kishore Guda, Flora Guerra, Consuelo Guerri, Prasun Guha, Carlos Guillén, Shashi Gujar, Anna Gukovskaya, Ilya Gukovsky, Jan Gunst, Andreas Günther, Anyonya R Guntur, Chuanyong Guo, Chun Guo, Hongqing Guo, Lian-Wang Guo, Ming Guo, Pawan Gupta, Shashi Kumar Gupta, Swapnil Gupta, Veer Bala Gupta, Vivek Gupta, Asa B Gustafsson, David D Gutterman, Ranjitha H B, Annakaisa Haapasalo, James E Haber, Aleksandra Hać, Shinji Hadano, Anders J Hafrén, Mansour Haidar, Belinda S Hall, Gunnel Halldén, Anne Hamacher-Brady, Andrea Hamann, Maho Hamasaki, Weidong Han, Malene Hansen, Phyllis I Hanson, Zijian Hao, Masaru Harada, Ljubica Harhaji-Trajkovic, Nirmala Hariharan, Nigil Haroon, James Harris, Takafumi Hasegawa, Noor Hasima Nagoor, Jeffrey A Haspel, Volker Haucke, Wayne D Hawkins, Bruce A Hay, Cole M Haynes, Soren B Hayrabedyan, Thomas S Hays, Congcong He, Qin He, Rong-Rong He, You-Wen He, Yu-Ying He, Yasser Heakal, Alexander M Heberle, J Fielding Hejtmancik, Gudmundur Vignir Helgason, Vanessa Henkel, Marc Herb, Alexander Hergovich, Anna Herman-Antosiewicz, Agustín Hernández, Carlos Hernandez, Sergio Hernandez-Diaz, Virginia Hernandez-Gea, Amaury Herpin, Judit Herreros, Javier H Hervás, Daniel Hesselson, Claudio Hetz, Volker T Heussler, Yujiro Higuchi, Sabine Hilfiker, Joseph A Hill, William S Hlavacek, Emmanuel A Ho, Idy H T Ho, Philip Wing-Lok Ho, Shu-Leong Ho, Wan Yun Ho, G Aaron Hobbs, Mark Hochstrasser, Peter H M Hoet, Daniel Hofius, Paul Hofman, Annika Höhn, Carina I Holmberg, Jose R Hombrebueno, Chang-Won Hong Yi-Ren Hong, Lora V Hooper, Thorsten Hoppe, Rastislav Horos, Yujin Hoshida, I-Lun Hsin, Hsin-Yun Hsu, Bing Hu, Dong Hu, Li-Fang Hu, Ming Chang Hu, Ronggui Hu, Wei Hu, Yu-Chen Hu, Zhuo-Wei Hu, Fang Hua, Jinlian Hua, Yingqi Hua, Chongmin Huan, Canhua Huang, Chuanshu Huang, Chuanxin Huang, Chunling Huang, Haishan Huang, Kun Huang, Michael L H Huang, Rui Huang, Shan Huang, Tianzhi Huang, Xing Huang, Yuxiang Jack Huang, Tobias B Huber, Virginie Hubert, Christian A Hubner, Stephanie M Hughes, William E Hughes, Magali Humbert, Gerhard Hummer, James H Hurley, Sabah Hussain, Salik Hussain, Patrick J Hussey, Martina Hutabarat, Hui-Yun Hwang, Seungmin Hwang, Antonio Ieni, Fumiyo Ikeda, Yusuke Imagawa, Yuzuru Imai, Carol Imbriano, Masaya Imoto, Denise M Inman, Ken Inoki, Juan Iovanna, Renato V Iozzo, Giuseppe Ippolito, Javier E Irazoqui, Pablo Iribarren, Mohd Ishaq, Makoto Ishikawa, Nestor Ishimwe, Ciro Isidoro, Nahed Ismail, Shohreh Issazadeh-Navikas, Eisuke Itakura, Daisuke Ito, Davor Ivankovic, Saška Ivanova, Anand Krishnan V Iyer, José M Izquierdo, Masanori Izumi, Marja Jäättelä, Majid Sakhi Jabir, William T Jackson, Nadia Jacobo-Herrera, Anne-Claire Jacomin, Elise Jacquin, Pooja Jadiya, Hartmut Jaeschke, Chinnaswamy Jagannath, Arjen J Jakobi, Johan Jakobsson, Bassam Janji, Pidder Jansen-Dürr, Patric J Jansson, Jonathan Jantsch, Sławomir Januszewski, Alagie Jassey, Steve Jean, Hélène Jeltsch-David, Pavla Jendelova, Andreas Jenny, Thomas E Jensen, Niels Jessen, Jenna L Jewell, Jing Ji, Lijun Jia, Rui Jia, Liwen Jiang, Qing Jiang, Richeng Jiang, Teng Jiang, Xuejun Jiang, Yu Jiang, Maria Jimenez-Sanchez, Eun-Jung Jin, Fengyan Jin, Hongchuan Jin, Li Jin, Luqi Jin, Meiyan Jin, Si Jin, Eun-Kyeong Jo, Carine Joffre, Terje Johansen, Gail V W Johnson, Simon A Johnston, Eija Jokitalo, Mohit Kumar Jolly, Leo A B Joosten, Joaquin Jordan, Bertrand Joseph, Dianwen Ju, Jeong-Sun Ju, Jingfang Ju, Esmeralda Juárez, Delphine Judith, Gábor Juhász, Youngsoo Jun, Chang Hwa Jung, Sung-Chul Jung, Yong Keun Jung, Heinz Jungbluth, Johannes Jungverdorben, Steffen Just, Kai Kaarniranta, Allen Kaasik, Tomohiro Kabuta, Daniel Kaganovich, Alon Kahana, Renate Kain, Shinjo Kajimura, Maria Kalamvoki, Manjula Kalia, Danuta S Kalinowski, Nina Kaludercic, Ioanna Kalvari, Joanna Kaminska, Vitaliy O Kaminskyy, Hiromitsu Kanamori, Keizo Kanasaki, Chanhee Kang, Rui Kang, Sang Sun Kang, Senthilvelrajan Kaniyappan, Tomotake Kanki, Thirumala-Devi Kanneganti, Anumantha G Kanthasamy, Arthi Kanthasamy, Marc Kantorow, Orsolya Kapuy, Michalis V Karamouzis, Md Razaul Karim, Parimal Karmakar, Rajesh G Katare, Masaru Kato, Stefan H E Kaufmann, Anu Kauppinen, Gur P Kaushal, Susmita Kaushik, Kiyoshi Kawasaki, Kemal Kazan, Po-Yuan Ke, Damien J Keating, Ursula Keber, John H Kehrl, Kate E Keller, Christian W Keller, Jongsook Kim Kemper, Candia M Kenific, Oliver Kepp, Stephanie Kermorgant, Andreas Kern, Robin Ketteler, Tom G Keulers, Boris Khalfin, Hany Khalil, Bilon Khambu, Shahid Y Khan, Vinoth Kumar Megraj Khandelwal, Rekha Khandia, Widuri Kho, Noopur V Khobrekar, Sataree Khuansuwan, Mukhran Khundadze, Samuel A Killackey, Dasol Kim, Deok Ryong Kim, Do-Hyung Kim, Dong-Eun Kim, Eun Young Kim, Eun-Kyoung Kim, Hak-Rim Kim, Hee-Sik Kim, Hyung-Ryong Kim, Jeong Hun Kim, Jin Kyung Kim, Jin-Hoi Kim, Joungmok Kim, Ju Hwan Kim, Keun Il Kim, Peter K Kim, Seong-Jun Kim, Scot R Kimball, Adi Kimchi, Alec C Kimmelman, Tomonori Kimura, Matthew A King, Kerri J Kinghorn, Conan G Kinsey, Vladimir Kirkin, Lorrie A Kirshenbaum, Sergey L Kiselev, Shuji Kishi, Katsuhiko Kitamoto, Yasushi Kitaoka, Kaio Kitazato, Richard N Kitsis, Josef T Kittler, Ole Kjaerulff, Peter S Klein, Thomas Klopstock, Jochen Klucken, Helene Knævelsrud, Roland L Knorr, Ben C B Ko, Fred Ko, Jiunn-Liang Ko, Hotaka Kobayashi, Satoru Kobayashi, Ina Koch, Jan C Koch, Ulrich Koenig, Donat Kögel, Young Ho Koh, Masato Koike, Sepp D Kohlwein, Nur M Kocaturk, Masaaki Komatsu, Jeannette König, Toru Kono, Benjamin T Kopp, Tamas Korcsmaros, Gözde Korkmaz, Viktor I Korolchuk, Mónica Suárez Korsnes, Ali Koskela, Janaiah Kota, Yaichiro Kotake, Monica L Kotler, Yanjun Kou, Michael I Koukourakis, Evangelos Koustas, Attila L Kovacs, Tibor Kovács, Daisuke Koya, Tomohiro Kozako, Claudine Kraft, Dimitri Krainc, Helmut Krämer, Anna D Krasnodembskaya, Carole Kretz-Remy, Guido Kroemer, Nicholas T Ktistakis, Kazuyuki Kuchitsu, Sabine Kuenen, Lars Kuerschner, Thomas Kukar, Ajay Kumar, Ashok Kumar, Deepak Kumar, Dhiraj Kumar, Sharad Kumar, Shinji Kume, Caroline Kumsta, Chanakya N Kundu, Mondira Kundu, Ajaikumar B Kunnumakkara, Lukasz Kurgan, Tatiana G Kutateladze, Ozlem Kutlu, SeongAe Kwak, Ho Jeong Kwon, Taeg Kyu Kwon, Yong Tae Kwon, Irene Kyrmizi, Albert La Spada, Patrick Labonté, Sylvain Ladoire, Ilaria Laface, Frank Lafont, Diane C Lagace, Vikramjit Lahiri, Zhibing Lai, Angela S Laird, Aparna Lakkaraju, Trond Lamark, Sheng-Hui Lan, Ane Landajuela, Darius J R Lane, Jon D Lane, Charles H Lang, Carsten Lange, Ülo Langel, Rupert Langer, Pierre Lapaquette, Jocelyn Laporte, Nicholas F LaRusso, Isabel Lastres-Becker, Wilson Chun Yu Lau, Gordon W Laurie, Sergio Lavandero, Betty Yuen Kwan Law, Helen Ka-Wai Law, Rob Layfield, Weidong Le, Herve Le Stunff, Alexandre Y Leary, Jean-Jacques Lebrun, Lionel Y W Leck, Jean-Philippe Leduc-Gaudet, Changwook Lee, Chung-Pei Lee, Da-Hye Lee, Edward B Lee, Erinna F Lee, Gyun Min Lee, He-Jin Lee, Heung Kyu Lee, Jae Man Lee, Jason S Lee, Jin-A Lee, Joo-Yong Lee, Jun Hee Lee, Michael Lee, Min Goo Lee, Min Jae Lee, Myung-Shik Lee, Sang Yoon Lee, Seung-Jae Lee, Stella Y Lee, Sung Bae Lee, Won Hee Lee, Ying-Ray Lee, Yong-Ho Lee, Youngil Lee, Christophe Lefebvre, Renaud Legouis, Yu L Lei, Yuchen Lei, Sergey Leikin, Gerd Leitinger, Leticia Lemus, Shuilong Leng, Olivia Lenoir, Guido Lenz, Heinz Josef Lenz, Paola Lenzi, Yolanda León, Andréia M Leopoldino, Christoph Leschczyk, Stina Leskelä, Elisabeth Letellier, Chi-Ting Leung, Po Sing Leung, Jeremy S Leventhal, Beth Levine, Patrick A Lewis, Klaus Ley, Bin Li, Da-Qiang Li, Jianming Li, Jing Li, Jiong Li, Ke Li, Liwu Li, Mei Li, Min Li, Min Li, Ming Li, Mingchuan Li, Pin-Lan Li, Ming-Qing Li, Qing Li, Sheng Li, Tiangang Li, Wei Li, Wenming Li, Xue Li, Yi-Ping Li, Yuan Li, Zhiqiang Li, Zhiyong Li, Zhiyuan Li, Jiqin Lian, Chengyu Liang, Qiangrong Liang, Weicheng Liang, Yongheng Liang, YongTian Liang, Guanghong Liao, Lujian Liao, Mingzhi Liao, Yung-Feng Liao, Mariangela Librizzi, Pearl P Y Lie, Mary A Lilly, Hyunjung J Lim, Thania R R Lima, Federica Limana, Chao Lin, Chih-Wen Lin, Dar-Shong Lin, Fu-Cheng Lin, Jiandie D Lin, Kurt M Lin, Kwang-Huei Lin, Liang-Tzung Lin, Pei-Hui Lin, Qiong Lin, Shaofeng Lin, Su-Ju Lin, Wenyu Lin, Xueying Lin, Yao-Xin Lin, Yee-Shin Lin, Rafael Linden, Paula Lindner, Shuo-Chien Ling, Paul Lingor, Amelia K Linnemann, Yih-Cherng Liou, Marta M Lipinski, Saška Lipovšek, Vitor A Lira, Natalia Lisiak, Paloma B Liton, Chao Liu, Ching-Hsuan Liu, Chun-Feng Liu, Cui Hua Liu, Fang Liu, Hao Liu, Hsiao-Sheng Liu, Hua-Feng Liu, Huifang Liu, Jia Liu, Jing Liu, Julia Liu, Leyuan Liu, Longhua Liu, Meilian Liu, Qin Liu, Wei Liu, Wende Liu, Xiao-Hong Liu, Xiaodong Liu, Xingguo Liu, Xu Liu, Xuedong Liu, Yanfen Liu, Yang Liu, Yang Liu, Yueyang Liu, Yule Liu, J Andrew Livingston, Gerard Lizard, Jose M Lizcano, Senka Ljubojevic-Holzer, Matilde E LLeonart, David Llobet-Navàs, Alicia Llorente, Chih Hung Lo, Damián Lobato-Márquez, Qi Long, Yun Chau Long, Ben Loos, Julia A Loos, Manuela G López, Guillermo López-Doménech, José Antonio López-Guerrero, Ana T López-Jiménez, Óscar López-Pérez, Israel López-Valero, Magdalena J Lorenowicz, Mar Lorente, Peter Lorincz, Laura Lossi, Sophie Lotersztajn, Penny E Lovat, Jonathan F Lovell, Alenka Lovy, Péter Lőw, Guang Lu, Haocheng Lu, Jia-Hong Lu, Jin-Jian Lu, Mengji Lu, Shuyan Lu, Alessandro Luciani, John M Lucocq, Paula Ludovico, Micah A Luftig, Morten Luhr, Diego Luis-Ravelo, Julian J Lum, Liany Luna-Dulcey, Anders H Lund, Viktor K Lund, Jan D Lünemann, Patrick Lüningschrör, Honglin Luo, Rongcan Luo, Shouqing Luo, Zhi Luo, Claudio Luparello, Bernhard Lüscher, Luan Luu, Alex Lyakhovich, Konstantin G Lyamzaev, Alf Håkon Lystad, Lyubomyr Lytvynchuk, Alvin C Ma, Changle Ma, Mengxiao Ma, Ning-Fang Ma, Quan-Hong Ma, Xinliang Ma, Yueyun Ma, Zhenyi Ma, Ormond A MacDougald, Fernando Macian, Gustavo C MacIntosh, Jeffrey P MacKeigan, Kay F Macleod, Sandra Maday, Frank Madeo, Muniswamy Madesh, Tobias Madl, Julio Madrigal-Matute, Akiko Maeda, Yasuhiro Maejima, Marta Magarinos, Poornima Mahavadi, Emiliano Maiani, Kenneth Maiese, Panchanan Maiti, Maria Chiara Maiuri, Barbara Majello, Michael B Major, Elena Makareeva, Fayaz Malik, Karthik Mallilankaraman, Walter Malorni, Alina Maloyan, Najiba Mammadova, Gene Chi Wai Man, Federico Manai, Joseph D Mancias, Eva-Maria Mandelkow, Michael A Mandell, Angelo A Manfredi, Masoud H Manjili, Ravi Manjithaya, Patricio Manque, Bella B Manshian, Raquel Manzano, Claudia Manzoni, Kai Mao, Cinzia Marchese, Sandrine Marchetti, Anna Maria Marconi, Fabrizio Marcucci, Stefania Mardente, Olga A Mareninova, Marta Margeta, Muriel Mari, Sara Marinelli, Oliviero Marinelli, Guillermo Mariño, Sofia Mariotto, Richard S Marshall, Mark R Marten, Sascha Martens, Alexandre P J Martin, Katie R Martin, Sara Martin, Shaun Martin, Adrián Martín-Segura, Miguel A Martín-Acebes, Inmaculada Martin-Burriel, Marcos Martin-Rincon, Paloma Martin-Sanz, José A Martina, Wim Martinet, Aitor Martinez, Ana Martinez, Jennifer Martinez, Moises Martinez Velazquez, Nuria Martinez-Lopez, Marta Martinez-Vicente, Daniel O Martins, Joilson O Martins, Waleska K Martins, Tania Martins-Marques, Emanuele Marzetti, Shashank Masaldan, Celine Masclaux-Daubresse, Douglas G Mashek, Valentina Massa, Lourdes Massieu, Glenn R Masson, Laura Masuelli, Anatoliy I Masyuk, Tetyana V Masyuk, Paola Matarrese, Ander Matheu, Satoaki Matoba, Sachiko Matsuzaki, Pamela Mattar, Alessandro Matte, Domenico Mattoscio, José L Mauriz, Mario Mauthe, Caroline Mauvezin, Emanual Maverakis, Paola Maycotte, Johanna Mayer, Gianluigi Mazzoccoli, Cristina Mazzoni, Joseph R Mazzulli, Nami McCarty, Christine McDonald, Mitchell R McGill, Sharon L McKenna, BethAnn McLaughlin, Fionn McLoughlin, Mark A McNiven, Thomas G McWilliams, Fatima Mechta-Grigoriou, Tania Catarina Medeiros, Diego L Medina, Lynn A Megeney, Klara Megyeri, Maryam Mehrpour, Jawahar L Mehta, Alfred J Meijer, Annemarie H Meijer, Jakob Mejlvang, Alicia Meléndez, Annette Melk, Gonen Memisoglu, Alexandrina F Mendes, Delong Meng, Fei Meng, Tian Meng, Rubem Menna-Barreto, Manoj B Menon, Carol Mercer, Anne E Mercier, Jean-Louis Mergny, Adalberto Merighi, Seth D Merkley, Giuseppe Merla, Volker Meske, Ana Cecilia Mestre, Shree Padma Metur, Christian Meyer, Hemmo Meyer, Wenyi Mi, Jeanne Mialet-Perez, Junying Miao, Lucia Micale, Yasuo Miki, Enrico Milan, Małgorzata Milczarek, Dana L Miller, Samuel I Miller, Silke Miller, Steven W Millward, Ira Milosevic, Elena A Minina, Hamed Mirzaei, Hamid Reza Mirzaei, Mehdi Mirzaei, Amit Mishra, Nandita Mishra, Paras Kumar Mishra, Maja Misirkic Marjanovic, Roberta Misasi, Amit Misra, Gabriella Misso, Claire Mitchell, Geraldine Mitou, Tetsuji Miura, Shigeki Miyamoto, Makoto Miyazaki, Mitsunori Miyazaki, Taiga Miyazaki, Keisuke Miyazawa, Noboru Mizushima, Trine H Mogensen, Baharia Mograbi, Reza Mohammadinejad, Yasir Mohamud, Abhishek Mohanty, Sipra Mohapatra, Torsten Möhlmann, Asif Mohmmed, Anna Moles, Kelle H Moley, Maurizio Molinari, Vincenzo Mollace, Andreas Buch Møller, Bertrand Mollereau, Faustino Mollinedo, Costanza Montagna, Mervyn J Monteiro, Andrea Montella, L Ruth Montes, Barbara Montico, Vinod K Mony, Giacomo Monzio Compagnoni, Michael N Moore, Mohammad A Moosavi, Ana L Mora, Marina Mora, David Morales-Alamo, Rosario Moratalla, Paula I Moreira, Elena Morelli, Sandra Moreno, Daniel Moreno-Blas, Viviana Moresi, Benjamin Morga, Alwena H Morgan, Fabrice Morin, Hideaki Morishita, Orson L Moritz, Mariko Moriyama, Yuji Moriyasu, Manuela Morleo, Eugenia Morselli, Jose F Moruno-Manchon, Jorge Moscat, Serge Mostowy, Elisa Motori, Andrea Felinto Moura, Naima Moustaid-Moussa, Maria Mrakovcic, Gabriel Muciño-Hernández, Anupam Mukherjee, Subhadip Mukhopadhyay, Jean M Mulcahy Levy, Victoriano Mulero, Sylviane Muller, Christian Münch, Ashok Munjal, Pura Munoz-Canoves, Teresa Muñoz-Galdeano, Christian Münz, Tomokazu Murakawa, Claudia Muratori, Brona M Murphy, J Patrick Murphy, Aditya Murthy, Timo T Myöhänen, Indira U Mysorekar, Jennifer Mytych, Seyed Mohammad Nabavi, Massimo Nabissi, Péter Nagy, Jihoon Nah, Aimable Nahimana, Ichiro Nakagawa, Ken Nakamura, Hitoshi Nakatogawa, Shyam S Nandi, Meera Nanjundan, Monica Nanni, Gennaro Napolitano, Roberta Nardacci, Masashi Narita, Melissa Nassif, Ilana Nathan, Manabu Natsumeda, Ryno J Naude, Christin Naumann, Olaia Naveiras, Fatemeh Navid, Steffan T Nawrocki, Taras Y Nazarko, Francesca Nazio, Florentina Negoita, Thomas Neill, Amanda L Neisch, Luca M Neri, Mihai G Netea, Patrick Neubert, Thomas P Neufeld, Dietbert Neumann, Albert Neutzner, Phillip T Newton, Paul A Ney, Ioannis P Nezis, Charlene C W Ng, Tzi Bun Ng, Hang T T Nguyen, Long T Nguyen, Hong-Min Ni, Clíona Ní Cheallaigh, Zhenhong Ni, M Celeste Nicolao, Francesco Nicoli, Manuel Nieto-Diaz, Per Nilsson, Shunbin Ning, Rituraj Niranjan, Hiroshi Nishimune, Mireia Niso-Santano, Ralph A Nixon, Annalisa Nobili, Clevio Nobrega, Takeshi Noda, Uxía Nogueira-Recalde, Trevor M Nolan, Ivan Nombela, Ivana Novak, Beatriz Novoa, Takashi Nozawa, Nobuyuki Nukina, Carmen Nussbaum-Krammer, Jesper Nylandsted, Tracey R O'Donovan, Seónadh M O'Leary, Eyleen J O'Rourke, Mary P O'Sullivan, Timothy E O'Sullivan, Salvatore Oddo, Ina Oehme, Michinaga Ogawa, Eric Ogier-Denis, Margret H Ogmundsdottir, Besim Ogretmen, Goo Taeg Oh, Seon-Hee Oh, Young J Oh, Takashi Ohama, Yohei Ohashi, Masaki Ohmuraya, Vasileios Oikonomou, Rani Ojha, Koji Okamoto, Hitoshi Okazawa, Masahide Oku, Sara Oliván, Jorge M A Oliveira, Michael Ollmann, James A Olzmann, Shakib Omari, M Bishr Omary, Gizem Önal, Martin Ondrej, Sang-Bing Ong, Sang-Ging Ong, Anna Onnis, Juan A Orellana, Sara Orellana-Muñoz, Maria Del Mar Ortega-Villaizan, Xilma R Ortiz-Gonzalez, Elena Ortona, Heinz D Osiewacz, Abdel-Hamid K Osman, Rosario Osta, Marisa S Otegui, Kinya Otsu, Christiane Ott, Luisa Ottobrini, Jing-Hsiung James Ou, Tiago F Outeiro, Inger Oynebraten, Melek Ozturk, Gilles Pagès, Susanta Pahari, Marta Pajares, Utpal B Pajvani, Rituraj Pal, Simona Paladino, Nicolas Pallet, Michela Palmieri, Giuseppe Palmisano, Camilla Palumbo, Francesco Pampaloni, Lifeng Pan, Qingjun Pan, Wenliang Pan, Xin Pan, Ganna Panasyuk, Rahul Pandey, Udai B Pandey, Vrajesh Pandya, Francesco Paneni, Shirley Y Pang, Elisa Panzarini, Daniela L Papademetrio, Elena Papaleo, Daniel Papinski, Diana Papp, Eun Chan Park, Hwan Tae Park, Ji-Man Park, Jong-In Park, Joon Tae Park, Junsoo Park, Sang Chul Park, Sang-Youel Park, Abraham H Parola, Jan B Parys, Adrien Pasquier, Benoit Pasquier, João F Passos, Nunzia Pastore, Hemal H Patel, Daniel Patschan, Sophie Pattingre, Gustavo Pedraza-Alva, Jose Pedraza-Chaverri, Zully Pedrozo, Gang Pei, Jianming Pei, Hadas Peled-Zehavi, Joaquín M Pellegrini, Joffrey Pelletier, Miguel A Peñalva, Di Peng, Ying Peng, Fabio Penna, Maria Pennuto, Francesca Pentimalli, Cláudia Mf Pereira, Gustavo J S Pereira, Lilian C Pereira, Luis Pereira de Almeida, Nirma D Perera, Ángel Pérez-Lara, Ana B Perez-Oliva, María Esther Pérez-Pérez, Palsamy Periyasamy, Andras Perl, Cristiana Perrotta, Ida Perrotta, Richard G Pestell, Morten Petersen, Irina Petrache, Goran Petrovski, Thorsten Pfirrmann, Astrid S Pfister, Jennifer A Philips, Huifeng Pi, Anna Picca, Alicia M Pickrell, Sandy Picot, Giovanna M Pierantoni, Marina Pierdominici, Philippe Pierre, Valérie Pierrefite-Carle, Karolina Pierzynowska, Federico Pietrocola, Miroslawa Pietruczuk, Claudio Pignata, Felipe X Pimentel-Muiños, Mario Pinar, Roberta O Pinheiro, Ronit Pinkas-Kramarski, Paolo Pinton, Karolina Pircs, Sujan Piya, Paola Pizzo, Theo S Plantinga, Harald W Platta, Ainhoa Plaza-Zabala, Markus Plomann, Egor Y Plotnikov, Helene Plun-Favreau, Ryszard Pluta, Roger Pocock, Stefanie Pöggeler, Christian Pohl, Marc Poirot, Angelo Poletti, Marisa Ponpuak, Hana Popelka, Blagovesta Popova, Helena Porta, Soledad Porte Alcon, Eliana Portilla-Fernandez, Martin Post, Malia B Potts, Joanna Poulton, Ted Powers, Veena Prahlad, Tomasz K Prajsnar, Domenico Praticò, Rosaria Prencipe, Muriel Priault, Tassula Proikas-Cezanne, Vasilis J Promponas, Christopher G Proud, Rosa Puertollano, Luigi Puglielli, Thomas Pulinilkunnil, Deepika Puri, Rajat Puri, Julien Puyal, Xiaopeng Qi, Yongmei Qi, Wenbin Qian, Lei Qiang, Yu Qiu, Joe Quadrilatero, Jorge Quarleri, Nina Raben, Hannah Rabinowich, Debora Ragona, Michael J Ragusa, Nader Rahimi, Marveh Rahmati, Valeria Raia, Nuno Raimundo, Namakkal-Soorappan Rajasekaran, Sriganesh Ramachandra Rao, Abdelhaq Rami, Ignacio Ramírez-Pardo, David B Ramsden, Felix Randow, Pundi N Rangarajan, Danilo Ranieri, Hai Rao, Lang Rao, Rekha Rao, Sumit Rathore, J Arjuna Ratnayaka, Edward A Ratovitski, Palaniyandi Ravanan, Gloria Ravegnini, Swapan K Ray, Babak Razani, Vito Rebecca, Fulvio Reggiori, Anne Régnier-Vigouroux, Andreas S Reichert, David Reigada, Jan H Reiling, Theo Rein, Siegfried Reipert, Rokeya Sultana Rekha, Hongmei Ren, Jun Ren, Weichao Ren, Tristan Renault, Giorgia Renga, Karen Reue, Kim Rewitz, Bruna Ribeiro de Andrade Ramos, S Amer Riazuddin, Teresa M Ribeiro-Rodrigues, Jean-Ehrland Ricci, Romeo Ricci, Victoria Riccio, Des R Richardson, Yasuko Rikihisa, Makarand V Risbud, Ruth M Risueño, Konstantinos Ritis, Salvatore Rizza, Rosario Rizzuto, Helen C Roberts, Luke D Roberts, Katherine J Robinson, Maria Carmela Roccheri, Stephane Rocchi, George G Rodney, Tiago Rodrigues, Vagner Ramon Rodrigues Silva, Amaia Rodriguez, Ruth Rodriguez-Barrueco, Nieves Rodriguez-Henche, Humberto Rodriguez-Rocha, Jeroen Roelofs, Robert S Rogers, Vladimir V Rogov, Ana I Rojo, Krzysztof Rolka, Vanina Romanello, Luigina Romani, Alessandra Romano, Patricia S Romano, David Romeo-Guitart, Luis C Romero, Montserrat Romero, Joseph C Roney, Christopher Rongo, Sante Roperto, Mathias T Rosenfeldt, Philip Rosenstiel, Anne G Rosenwald, Kevin A Roth, Lynn Roth, Steven Roth, Kasper M A Rouschop, Benoit D Roussel, Sophie Roux, Patrizia Rovere-Querini, Ajit Roy, Aurore Rozieres, Diego Ruano, David C Rubinsztein, Maria P Rubtsova, Klaus Ruckdeschel, Christoph Ruckenstuhl, Emil Rudolf, Rüdiger Rudolf, Alessandra Ruggieri, Avnika Ashok Ruparelia, Paola Rusmini, Ryan R Russell, Gian Luigi Russo, Maria Russo, Rossella Russo, Oxana O Ryabaya, Kevin M Ryan, Kwon-Yul Ryu, Maria Sabater-Arcis, Ulka Sachdev, Michael Sacher, Carsten Sachse, Abhishek Sadhu, Junichi Sadoshima, Nathaniel Safren, Paul Saftig, Antonia P Sagona, Gaurav Sahay, Amirhossein Sahebkar, Mustafa Sahin, Ozgur Sahin, Sumit Sahni, Nayuta Saito, Shigeru Saito, Tsunenori Saito, Ryohei Sakai, Yasuyoshi Sakai, Jun-Ichi Sakamaki, Kalle Saksela, Gloria Salazar, Anna Salazar-Degracia, Ghasem H Salekdeh, Ashok K Saluja, Belém Sampaio-Marques, Maria Cecilia Sanchez, Jose A Sanchez-Alcazar, Victoria Sanchez-Vera, Vanessa Sancho-Shimizu, J Thomas Sanderson, Marco Sandri, Stefano Santaguida, Laura Santambrogio, Magda M Santana, Giorgio Santoni, Alberto Sanz, Pascual Sanz, Shweta Saran, Marco Sardiello, Timothy J Sargeant, Apurva Sarin, Chinmoy Sarkar, Sovan Sarkar, Maria-Rosa Sarrias, Surajit Sarkar, Dipanka Tanu Sarmah, Jaakko Sarparanta, Aishwarya Sathyanarayan, Ranganayaki Sathyanarayanan, K Matthew Scaglione, Francesca Scatozza, Liliana Schaefer, Zachary T Schafer, Ulrich E Schaible, Anthony H V Schapira, Michael Scharl, Hermann M Schatzl, Catherine H Schein, Wiep Scheper, David Scheuring, Maria Vittoria Schiaffino, Monica Schiappacassi, Rainer Schindl, Uwe Schlattner, Oliver Schmidt, Roland Schmitt, Stephen D Schmidt, Ingo Schmitz, Eran Schmukler, Anja Schneider, Bianca E Schneider, Romana Schober, Alejandra C Schoijet, Micah B Schott, Michael Schramm, Bernd Schröder, Kai Schuh, Christoph Schüller, Ryan J Schulze, Lea Schürmanns, Jens C Schwamborn, Melanie Schwarten, Filippo Scialo, Sebastiano Sciarretta, Melanie J Scott, Kathleen W Scotto, A Ivana Scovassi, Andrea Scrima, Aurora Scrivo, David Sebastian, Salwa Sebti, Simon Sedej, Laura Segatori, Nava Segev, Per O Seglen, Iban Seiliez, Ekihiro Seki, Scott B Selleck, Frank W Sellke, Joshua T Selsby, Michael Sendtner, Serif Senturk, Elena Seranova, Consolato Sergi, Ruth Serra-Moreno, Hiromi Sesaki, Carmine Settembre, Subba Rao Gangi Setty, Gianluca Sgarbi, Ou Sha, John J Shacka, Javeed A Shah, Dantong Shang, Changshun Shao, Feng Shao, Soroush Sharbati, Lisa M Sharkey, Dipali Sharma, Gaurav Sharma, Kulbhushan Sharma, Pawan Sharma, Surendra Sharma, Han-Ming Shen, Hongtao Shen, Jiangang Shen, Ming Shen, Weili Shen, Zheni Shen, Rui Sheng, Zhi Sheng, Zu-Hang Sheng, Jianjian Shi, Xiaobing Shi, Ying-Hong Shi, Kahori Shiba-Fukushima, Jeng-Jer Shieh, Yohta Shimada, Shigeomi Shimizu, Makoto Shimozawa, Takahiro Shintani, Christopher J Shoemaker, Shahla Shojaei, Ikuo Shoji, Bhupendra V Shravage, Viji Shridhar, Chih-Wen Shu, Hong-Bing Shu, Ke Shui, Arvind K Shukla, Timothy E Shutt, Valentina Sica, Aleem Siddiqui, Amanda Sierra, Virginia Sierra-Torre, Santiago Signorelli, Payel Sil, Bruno J de Andrade Silva, Johnatas D Silva, Eduardo Silva-Pavez, Sandrine Silvente-Poirot, Rachel E Simmonds, Anna Katharina Simon, Hans-Uwe Simon, Matias Simons, Anurag Singh, Lalit P Singh, Rajat Singh, Shivendra V Singh, Shrawan K Singh, Sudha B Singh, Sunaina Singh, Surinder Pal Singh, Debasish Sinha, Rohit Anthony Sinha, Sangita Sinha, Agnieszka Sirko, Kapil Sirohi, Efthimios L Sivridis, Panagiotis Skendros, Aleksandra Skirycz, Iva Slaninová, Soraya S Smaili, Andrei Smertenko, Matthew D Smith, Stefaan J Soenen, Eun Jung Sohn, Sophia P M Sok, Giancarlo Solaini, Thierry Soldati, Scott A Soleimanpour, Rosa M Soler, Alexei Solovchenko, Jason A Somarelli, Avinash Sonawane, Fuyong Song, Hyun Kyu Song, Ju-Xian Song, Kunhua Song, Zhiyin Song, Leandro R Soria, Maurizio Sorice, Alexander A Soukas, Sandra-Fausia Soukup, Diana Sousa, Nadia Sousa, Paul A Spagnuolo, Stephen A Spector, M M Srinivas Bharath, Daret St Clair, Venturina Stagni, Leopoldo Staiano, Clint A Stalnecker, Metodi V Stankov, Peter B Stathopulos, Katja Stefan, Sven Marcel Stefan, Leonidas Stefanis, Joan S Steffan, Alexander Steinkasserer, Harald Stenmark, Jared Sterneckert, Craig Stevens, Veronika Stoka, Stephan Storch, Björn Stork, Flavie Strappazzon, Anne Marie Strohecker, Dwayne G Stupack, Huanxing Su, Ling-Yan Su, Longxiang Su, Ana M Suarez-Fontes, Carlos S Subauste, Selvakumar Subbian, Paula V Subirada, Ganapasam Sudhandiran, Carolyn M Sue, Xinbing Sui, Corey Summers, Guangchao Sun, Jun Sun, Kang Sun, Meng-Xiang Sun, Qiming Sun, Yi Sun, Zhongjie Sun, Karen K S Sunahara, Eva Sundberg, Katalin Susztak, Peter Sutovsky, Hidekazu Suzuki, Gary Sweeney, J David Symons, Stephen Cho Wing Sze, Nathaniel J Szewczyk, Anna Tabęcka-Łonczynska, Claudio Tabolacci, Frank Tacke, Heinrich Taegtmeyer, Marco Tafani, Mitsuo Tagaya, Haoran Tai, Stephen W G Tait, Yoshinori Takahashi, Szabolcs Takats, Priti Talwar, Chit Tam, Shing Yau Tam, Davide Tampellini, Atsushi Tamura, Chong Teik Tan, Eng-King Tan, Ya-Qin Tan, Masaki Tanaka, Motomasa Tanaka, Daolin Tang, Jingfeng Tang, Tie-Shan Tang, Isei Tanida, Zhipeng Tao, Mohammed Taouis, Lars Tatenhorst, Nektarios Tavernarakis, Allen Taylor, Gregory A Taylor, Joan M Taylor, Elena Tchetina, Andrew R Tee, Irmgard Tegeder, David Teis, Natercia Teixeira, Fatima Teixeira-Clerc, Kumsal A Tekirdag, Tewin Tencomnao, Sandra Tenreiro, Alexei V Tepikin, Pilar S Testillano, Gianluca Tettamanti, Pierre-Louis Tharaux, Kathrin Thedieck, Arvind A Thekkinghat, Stefano Thellung, Josephine W Thinwa, V P Thirumalaikumar, Sufi Mary Thomas, Paul G Thomes, Andrew Thorburn, Lipi Thukral, Thomas Thum, Michael Thumm, Ling Tian, Ales Tichy, Andreas Till, Vincent Timmerman, Vladimir I Titorenko, Sokol V Todi, Krassimira Todorova, Janne M Toivonen, Luana Tomaipitinca, Dhanendra Tomar, Cristina Tomas-Zapico, Sergej Tomić, Benjamin Chun-Kit Tong, Chao Tong, Xin Tong, Sharon A Tooze, Maria L Torgersen, Satoru Torii, Liliana Torres-López, Alicia Torriglia, Christina G Towers, Roberto Towns, Shinya Toyokuni, Vladimir Trajkovic, Donatella Tramontano, Quynh-Giao Tran, Leonardo H Travassos, Charles B Trelford, Shirley Tremel, Ioannis P Trougakos, Betty P Tsao, Mario P Tschan, Hung-Fat Tse, Tak Fu Tse, Hitoshi Tsugawa, Andrey S Tsvetkov, David A Tumbarello, Yasin Tumtas, María J Tuñón, Sandra Turcotte, Boris Turk, Vito Turk, Bradley J Turner, Richard I Tuxworth, Jessica K Tyler, Elena V Tyutereva, Yasuo Uchiyama, Aslihan Ugun-Klusek, Holm H Uhlig, Marzena Ułamek-Kozioł, Ilya V Ulasov, Midori Umekawa, Christian Ungermann, Rei Unno, Sylvie Urbe, Elisabet Uribe-Carretero, Suayib Üstün, Vladimir N Uversky, Thomas Vaccari, Maria I Vaccaro, Björn F Vahsen, Helin Vakifahmetoglu-Norberg, Rut Valdor, Maria J Valente, Ayelén Valko, Richard B Vallee, Angela M Valverde, Greet Van den Berghe, Stijn van der Veen, Luc Van Kaer, Jorg van Loosdregt, Sjoerd J L van Wijk, Wim Vandenberghe, Ilse Vanhorebeek, Marcos A Vannier-Santos, Nicola Vannini, M Cristina Vanrell, Chiara Vantaggiato, Gabriele Varano, Isabel Varela-Nieto, Máté Varga, M Helena Vasconcelos, Somya Vats, Demetrios G Vavvas, Ignacio Vega-Naredo, Silvia Vega-Rubin-de-Celis, Guillermo Velasco, Ariadna P Velázquez, Tibor Vellai, Edo Vellenga, Francesca Velotti, Mireille Verdier, Panayotis Verginis, Isabelle Vergne, Paul Verkade, Manish Verma, Patrik Verstreken, Tim Vervliet, Jörg Vervoorts, Alexandre T Vessoni, Victor M Victor, Michel Vidal, Chiara Vidoni, Otilia V Vieira, Richard D Vierstra, Sonia Viganó, Helena Vihinen, Vinoy Vijayan, Miquel Vila, Marçal Vilar, José M Villalba, Antonio Villalobo, Beatriz Villarejo-Zori, Francesc Villarroya, Joan Villarroya, Olivier Vincent, Cecile Vindis, Christophe Viret, Maria Teresa Viscomi, Dora Visnjic, Ilio Vitale, David J Vocadlo, Olga V Voitsekhovskaja, Cinzia Volonté, Mattia Volta, Marta Vomero, Clarissa Von Haefen, Marc A Vooijs, Wolfgang Voos, Ljubica Vucicevic, Richard Wade-Martins, Satoshi Waguri, Kenrick A Waite, Shuji Wakatsuki, David W Walker, Mark J Walker, Simon A Walker, Jochen Walter, Francisco G Wandosell, Bo Wang, Chao-Yung Wang, Chen Wang, Chenran Wang, Chenwei Wang, Cun-Yu Wang, Dong Wang, Fangyang Wang, Feng Wang, Fengming Wang, Guansong Wang, Han Wang, Hao Wang, Hexiang Wang, Hong-Gang Wang, Jianrong Wang, Jigang Wang, Jiou Wang, Jundong Wang, Kui Wang, Lianrong Wang, Liming Wang, Maggie Haitian Wang, Meiqing Wang, Nanbu Wang, Pengwei Wang, Peipei Wang, Ping Wang, Ping Wang, Qing Jun Wang, Qing Wang, Qing Kenneth Wang, Qiong A Wang, Wen-Tao Wang, Wuyang Wang, Xinnan Wang, Xuejun Wang, Yan Wang, Yanchang Wang, Yanzhuang Wang, Yen-Yun Wang, Yihua Wang, Yipeng Wang, Yu Wang, Yuqi Wang, Zhe Wang, Zhenyu Wang, Zhouguang Wang, Gary Warnes, Verena Warnsmann, Hirotaka Watada, Eizo Watanabe, Maxinne Watchon, Anna Wawrzyńska, Timothy E Weaver, Grzegorz Wegrzyn, Ann M Wehman, Huafeng Wei, Lei Wei, Taotao Wei, Yongjie Wei, Oliver H Weiergräber, Conrad C Weihl, Günther Weindl, Ralf Weiskirchen, Alan Wells, Runxia H Wen, Xin Wen, Antonia Werner, Beatrice Weykopf, Sally P Wheatley, J Lindsay Whitton, Alexander J Whitworth, Katarzyna Wiktorska, Manon E Wildenberg, Tom Wileman, Simon Wilkinson, Dieter Willbold, Brett Williams, Robin S B Williams, Roger L Williams, Peter R Williamson, Richard A Wilson, Beate Winner, Nathaniel J Winsor, Steven S Witkin, Harald Wodrich, Ute Woehlbier, Thomas Wollert, Esther Wong, Jack Ho Wong, Richard W Wong, Vincent Kam Wai Wong, W Wei-Lynn Wong, An-Guo Wu, Chengbiao Wu, Jian Wu, Junfang Wu, Kenneth K Wu, Min Wu, Shan-Ying Wu, Shengzhou Wu, Shu-Yan Wu, Shufang Wu, William K K Wu, Xiaohong Wu, Xiaoqing Wu, Yao-Wen Wu, Yihua Wu, Ramnik J Xavier, Hongguang Xia, Lixin Xia, Zhengyuan Xia, Ge Xiang, Jin Xiang, Mingliang Xiang, Wei Xiang, Bin Xiao, Guozhi Xiao, Hengyi Xiao, Hong-Tao Xiao, Jian Xiao, Lan Xiao, Shi Xiao, Yin Xiao, Baoming Xie, Chuan-Ming Xie, Min Xie, Yuxiang Xie, Zhiping Xie, Zhonglin Xie, Maria Xilouri, Congfeng Xu, En Xu, Haoxing Xu, Jing Xu, JinRong Xu, Liang Xu, Wen Wen Xu, Xiulong Xu, Yu Xue, Sokhna M S Yakhine-Diop, Masamitsu Yamaguchi, Osamu Yamaguchi, Ai Yamamoto, Shunhei Yamashina, Shengmin Yan, Shian-Jang Yan, Zhen Yan, Yasuo Yanagi, Chuanbin Yang, Dun-Sheng Yang, Huan Yang, Huang-Tian Yang, Hui Yang, Jin-Ming Yang, Jing Yang, Jingyu Yang, Ling Yang, Liu Yang, Ming Yang, Pei-Ming Yang, Qian Yang, Seungwon Yang, Shu Yang, Shun-Fa Yang, Wannian Yang, Wei Yuan Yang, Xiaoyong Yang, Xuesong Yang, Yi Yang, Ying Yang, Honghong Yao, Shenggen Yao, Xiaoqiang Yao, Yong-Gang Yao, Yong-Ming Yao, Takahiro Yasui, Meysam Yazdankhah, Paul M Yen, Cong Yi, Xiao-Ming Yin, Yanhai Yin, Zhangyuan Yin, Ziyi Yin, Meidan Ying, Zheng Ying, Calvin K Yip, Stephanie Pei Tung Yiu, Young H Yoo, Kiyotsugu Yoshida, Saori R Yoshii, Tamotsu Yoshimori, Bahman Yousefi, Boxuan Yu, Haiyang Yu, Jun Yu, Jun Yu, Li Yu, Ming-Lung Yu, Seong-Woon Yu, Victor C Yu, W Haung Yu, Zhengping Yu, Zhou Yu, Junying Yuan, Ling-Qing Yuan, Shilin Yuan, Shyng-Shiou F Yuan, Yanggang Yuan, Zengqiang Yuan, Jianbo Yue, Zhenyu Yue, Jeanho Yun, Raymond L Yung, David N Zacks, Gabriele Zaffagnini, Vanessa O Zambelli, Isabella Zanella, Qun S Zang, Sara Zanivan, Silvia Zappavigna, Pilar Zaragoza, Konstantinos S Zarbalis, Amir Zarebkohan, Amira Zarrouk, Scott O Zeitlin, Jialiu Zeng, Ju-Deng Zeng, Eva Žerovnik, Lixuan Zhan, Bin Zhang, Donna D Zhang, Hanlin Zhang, Hong Zhang, Hong Zhang, Honghe Zhang, Huafeng Zhang, Huaye Zhang, Hui Zhang, Hui-Ling Zhang, Jianbin Zhang, Jianhua Zhang, Jing-Pu Zhang, Kalin Y B Zhang, Leshuai W Zhang, Lin Zhang, Lisheng Zhang, Lu Zhang, Luoying Zhang, Menghuan Zhang, Peng Zhang, Sheng Zhang, Wei Zhang, Xiangnan Zhang, Xiao-Wei Zhang, Xiaolei Zhang, Xiaoyan Zhang, Xin Zhang, Xinxin Zhang, Xu Dong Zhang, Yang Zhang, Yanjin Zhang, Yi Zhang, Ying-Dong Zhang, Yingmei Zhang, Yuan-Yuan Zhang, Yuchen Zhang, Zhe Zhang, Zhengguang Zhang, Zhibing Zhang, Zhihai Zhang, Zhiyong Zhang, Zili Zhang, Haobin Zhao, Lei Zhao, Shuang Zhao, Tongbiao Zhao, Xiao-Fan Zhao, Ying Zhao, Yongchao Zhao, Yongliang Zhao, Yuting Zhao, Guoping Zheng, Kai Zheng, Ling Zheng, Shizhong Zheng, Xi-Long Zheng, Yi Zheng, Zu-Guo Zheng, Boris Zhivotovsky, Qing Zhong, Ao Zhou, Ben Zhou, Cefan Zhou, Gang Zhou, Hao Zhou, Hong Zhou, Hongbo Zhou, Jie Zhou, Jing Zhou, Jing Zhou, Jiyong Zhou, Kailiang Zhou, Rongjia Zhou, Xu-Jie Zhou, Yanshuang Zhou, Yinghong Zhou, Yubin Zhou, Zheng-Yu Zhou, Zhou Zhou, Binglin Zhu, Changlian Zhu, Guo-Qing Zhu, Haining Zhu, Hongxin Zhu, Hua Zhu, Wei-Guo Zhu, Yanping Zhu, Yushan Zhu, Haixia Zhuang, Xiaohong Zhuang, Katarzyna Zientara-Rytter, Christine M Zimmermann, Elena Ziviani, Teresa Zoladek, Wei-Xing Zong, Dmitry B Zorov, Antonio Zorzano, Weiping Zou, Zhen Zou, Zhengzhi Zou, Steven Zuryn, Werner Zwerschke, Beate Brand-Saberi, X Charlie Dong, Chandra Shekar Kenchappa, Zuguo Li, Yong Lin, Shigeru Oshima, Yueguang Rong, Judith C Sluimer, Christina L Stallings, Chun-Kit Tong

    Autophagy   17 ( 1 )   1 - 382   2021年1月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field.

    DOI： 10.1080/15548627.2020.1797280

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  • Effects of empagliflozin versus placebo on cardiac sympathetic activity in acute myocardial infarction patients with type 2 diabetes mellitus: The EMBODY trial

    Wataru Shimizu, Yoshiaki Kubota, Yu Hoshika, Kosuke Mozawa, Shuhei Tara, Yukichi Tokita, Kenji Yodogawa, Yu Ki Iwasaki, Takeshi Yamamoto, Hitoshi Takano, Yayoi Tsukada, Kuniya Asai, Masaaki Miyamoto, Yasushi Miyauchi, Eitaro Kodani, Masahiro Ishikawa, Mitsunori Maruyama, Michio Ogano, Jun Tanabe, Reiko Shiomura, Isamu Fukuizumi, Junya Matsuda, Satsuki Noma, Hideto Sangen, Hidenori Komiyama, Yoichi Imori, Shunichi Nakamura, Jun Nakata, Hideki Miyachi, Gen Takagi, Takahiro Todoroki, Takeshi Ikeda, Tomoyo Miyakuni, Ayaka Shima, Masato Matsushita, Hirotake Okazaki, Akihiro Shirakabe, Nobuaki Kobayashi, Masamitsu Takano, Yoshihiko Seino, Yugo Nishi, Keishi Suzuki, Junsuke Shibuya, Tsunenori Saito, Hiroyuki Nakano, Morisawa Taichirou, Erito Furuse, Kenji Nakama, Yusuke Hosokawa, Ippei Tsuboi, Hidekazu Kawanaka

    Cardiovascular Diabetology   19 ( 1 )   2020年9月

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    掲載種別：研究論文（学術雑誌）  

    © 2020 The Author(s). Background: Protection from lethal ventricular arrhythmias leading to sudden cardiac death (SCD) is a crucial challenge after acute myocardial infarction (AMI). Cardiac sympathetic and parasympathetic activity can be noninvasively assessed using heart rate variability (HRV) and heart rate turbulence (HRT). The EMBODY trial was designed to determine whether the Sodium-glucose cotransporter 2 (SGLT2) inhibitor improves cardiac nerve activity. Methods: This prospective, multicenter, randomized, double-blind, placebo-controlled trial included patients with AMI and type 2 diabetes mellitus (T2DM) in Japan; 105 patients were randomized (1:1) to receive once-daily 10-mg empagliflozin or placebo. The primary endpoints were changes in HRV, e.g., the standard deviation of all 5-min mean normal RR intervals (SDANN) and the low-frequency-to-high-frequency (LF/HF) ratio from baseline to 24 weeks. Secondary endpoints were changes in other sudden cardiac death (SCD) surrogate markers such as HRT. Results: Overall, 96 patients were included (46, empagliflozin group; 50, placebo group). The changes in SDANN were + 11.6 and + 9.1 ms in the empagliflozin (P = 0.02) and placebo groups (P = 0.06), respectively. Change in LF/HF ratio was - 0.57 and - 0.17 in the empagliflozin (P = 0.01) and placebo groups (P = 0.43), respectively. Significant improvement was noted in HRT only in the empagliflozin group (P = 0.01). Whereas intergroup comparison on HRV and HRT showed no significant difference between the empagliflozin and placebo groups. Compared with the placebo group, the empagliflozin group showed significant decreases in body weight, systolic blood pressure, and uric acid. In the empagliflozin group, no adverse events were observed. Conclusions: This is the first randomized clinical data to evaluate the effect of empagliflozin on cardiac sympathetic and parasympathetic activity in patients with T2DM and AMI. Early SGLT2 inhibitor administration in AMI patients with T2DM might be effective in improving cardiac nerve activity without any adverse events. Trial Registration: The EMBODY trial was registered by the UMIN in November 2017 (ID: 000030158). UMIN000030158; https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000034442.

    DOI： 10.1186/s12933-020-01127-z

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  • Long-term prognostic value of ultrastructural features in dilated cardiomyopathy: comparison with cardiac magnetic resonance. 査読 国際誌

    Tsunenori Saito, Kuniya Asai, Masaki Tachi, Shigeru Sato, Kosuke Mozawa, Akiko Adachi, Yoshihiro Sasaki, Yasuo Amano, Kyoichi Mizuno, Shin-Ichiro Kumita, Wataru Shimizu

    ESC heart failure   7 ( 2 )   682 - 691   2020年4月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    AIMS: This study aims to determine the implications associated with long-term prognosis of heart failure (HF) in patients with dilated cardiomyopathy (DCM) presenting initially as decompensated HF. We stratified the phase of DCM patients without late gadolinium enhancement (LGE) based on ultrastructural changes in cardiomyocytes. METHODS AND RESULTS: Left ventricular (LV) endomyocardial biopsy was performed in 55 consecutive DCM patients with initial decompensated HF. Ultrastructural changes in cardiomyocytes detected by electron microscopy were compared with data including LGE with cardiac magnetic resonance and HF recurrence. Of the 55 DCM patients, 24 (44%) showed LGE, and 26 (47%) showed recurrence decompensated HF, while 23 patients (42%) showed autophagic vacuoles in cardiomyocytes by electron microscopy. Multivariate analysis identified atrial fibrillation [hazard ratio (HR), 3.40; 95% confidence interval (CI), 1.45-7.98], haemoglobin level (HR, 0.82; 95% CI, 0.68-0.99), beta-blocker use (HR, 0.18; 95% CI, 0.05-0.74), and autophagic vacuoles (HR, 0.25; 95% CI, 0.09-0.65) as predictors of HF recurrence in the total patient population. In patients without LGE, only autophagic vacuoles were independent predictors of readmission because of HF (HR, 0.29; 95% CI, 0.09-0.90). In patients with LGE, atrial fibrillation (HR, 19.10; 95% CI, 2.97-123.09), and mid-linear LGE (HR, 12.96; 95% CI, 2.02-82.94) were independent predictors of readmission because of HF. CONCLUSIONS: In DCM patients with LGE, characterised by progression of LV remodelling, the LGE pattern was a predictor of HF recurrence, whereas in patients without LGE, absence of autophagic vacuoles was a predictor of HF recurrence.

    DOI： 10.1002/ehf2.12662

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  • Phospholipidosis in cardiomyocytes suffering flecainide intoxication. 査読 国際誌

    Tsunenori Saito, Meiso Hayashi, Wataru Shimizu

    European heart journal   41 ( 10 )   1141 - 1141   2020年3月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1093/eurheartj/ehz833

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  • Is steroid therapy really banned for lymphocytic myocarditis before excluding viral infection? 査読 国際誌

    Tsunenori Saito, Hironori Katayama, Eitaro Kodani

    European heart journal   40 ( 12 )   1014 - 1015   2019年3月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1093/eurheartj/ehy738

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  • Eosinophilic myocarditis associated with anti-mitochondrial M2 antibodies: a mechanism underlying the onset of myocarditis. 査読 国際誌

    Tsunenori Saito, Eitaro Kodani, Hironori Katayama, Yoshiki Kusama

    European heart journal   39 ( 37 )   3480 - 3481   2018年10月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1093/eurheartj/ehy246

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  • Myocardial alterations in a patient with mucopolysaccharidosis type IS. 査読 国際誌

    Yuki Izumi, Tsunenori Saito, Shigeru Sato, Wataru Shimizu

    European heart journal   39 ( 20 )   1863 - 1863   2018年5月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Oxford University Press  

    DOI： 10.1093/eurheartj/ehy149

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  • Electron microscopy gain a glimpse into the pathogenesis of cardiac sarcoidosis. 査読 国際誌

    Yoshiko Kuribayashi, Kisho Ohtani, Tsunenori Saito, Tomomi Ide

    European heart journal. Cardiovascular Imaging   18 ( 8 )   944 - 944   2017年5月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：OXFORD UNIV PRESS  

    DOI： 10.1093/ehjci/jex152

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  • Electron Microscopy of Contact Between a Monocyte and a Multinucleated Giant Cell in Cardiac Sarcoidosis. 査読 国際誌

    Yuki Imaizumi, Kazuo Eguchi, Hiroki Imada, Kiyomi Hidano, Satoshi Niijima, Hirotoshi Kawata, Noriyoshi Fukushima, Tsunenori Saito, Michiaki Hiroe, Kazuomi Kario

    The Canadian journal of cardiology   32 ( 12 )   1577.e19-1577.e20 - 1577.e20   2016年12月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：ELSEVIER SCIENCE INC  

    DOI： 10.1016/j.cjca.2016.02.057

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  • Superiority of the extracellular volume fraction over the myocardial T1 value for the assessment of myocardial fibrosis in patients with non-ischemic cardiomyopathy. 査読 国際誌

    Keisuke Inui, Masaki Tachi, Tsunenori Saito, Yoshiaki Kubota, Koji Murai, Koji Kato, Hitoshi Takano, Yasuo Amano, Kuniya Asai, Wataru Shimizu

    Magnetic resonance imaging   34 ( 8 )   1141 - 5   2016年10月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：ELSEVIER SCIENCE INC  

    PURPOSE: This study aimed to assess the efficacies of the myocardial T1 value and the extracellular volume fraction (ECV) for determining the severity of myocardial fibrosis in patients with non-ischemic cardiomyopathy. MATERIALS AND METHODS: Myocardial fibrosis is considered the most important indicator of cardiac damage associated with non-ischemic cardiomyopathy. Recently, modified Look-Locker inversion recovery imaging (MOLLI) has been used for T1 mapping and measurement of the ECV for the assessment of myocardial fibrosis. The present study included 22 patients (mean age, 61.5±12.7; 21 male) with non-ischemic heart failure. Motion corrected myocardial T1 mapping was automatically performed using a MOLLI sequence, and the ECV was estimated from the pre- and post-contrast blood and myocardial T1 values corrected for the hematocrit level. All endomyocardial biopsy specimens were obtained from the inferoposterior left ventricular wall. The percentage of myocardial fibrosis (%F) was determined after Elastica Masson-Goldner staining as follows: (fibrosis area/[fibrosis area+myocardial area])×100. RESULTS: No correlation was noted between the %F and the pre- (r=0.290, p=0.191) or post-contrast T1 values (r=-0.190, p=0.398); however, a significant correlation was noted between the %F and ECV (r=0.750, p<0.001). CONCLUSIONS: In this study, the ECV reflected the extent of myocardial fibrosis, but the pre- and post-contrast T1 values did not. The ECV may be used to estimate the severity of myocardial fibrosis in patients with non-ischemic cardiomyopathy.

    DOI： 10.1016/j.mri.2016.05.008

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  • Crystalline cardiomyopathy due to secondary oxalosis after short-bowel syndrome and end-stage renal failure. 査読 国際誌

    Tsunenori Saito, Mariko Ikeda, Kuniya Asai, Wataru Shimizu

    Clinical research in cardiology : official journal of the German Cardiac Society   105 ( 8 )   714 - 716   2016年8月

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    記述言語：英語   出版者・発行元：SPRINGER HEIDELBERG  

    DOI： 10.1007/s00392-016-0981-1

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  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). 査読 国際誌

    Daniel J Klionsky, Kotb Abdelmohsen, Akihisa Abe, Md Joynal Abedin, Hagai Abeliovich, Abraham Acevedo Arozena, Hiroaki Adachi, Christopher M Adams, Peter D Adams, Khosrow Adeli, Peter J Adhihetty, Sharon G Adler, Galila Agam, Rajesh Agarwal, Manish K Aghi, Maria Agnello, Patrizia Agostinis, Patricia V Aguilar, Julio Aguirre-Ghiso, Edoardo M Airoldi, Slimane Ait-Si-Ali, Takahiko Akematsu, Emmanuel T Akporiaye, Mohamed Al-Rubeai, Guillermo M Albaiceta, Chris Albanese, Diego Albani, Matthew L Albert, Jesus Aldudo, Hana Algül, Mehrdad Alirezaei, Iraide Alloza, Alexandru Almasan, Maylin Almonte-Beceril, Emad S Alnemri, Covadonga Alonso, Nihal Altan-Bonnet, Dario C Altieri, Silvia Alvarez, Lydia Alvarez-Erviti, Sandro Alves, Giuseppina Amadoro, Atsuo Amano, Consuelo Amantini, Santiago Ambrosio, Ivano Amelio, Amal O Amer, Mohamed Amessou, Angelika Amon, Zhenyi An, Frank A Anania, Stig U Andersen, Usha P Andley, Catherine K Andreadi, Nathalie Andrieu-Abadie, Alberto Anel, David K Ann, Shailendra Anoopkumar-Dukie, Manuela Antonioli, Hiroshi Aoki, Nadezda Apostolova, Saveria Aquila, Katia Aquilano, Koichi Araki, Eli Arama, Agustin Aranda, Jun Araya, Alexandre Arcaro, Esperanza Arias, Hirokazu Arimoto, Aileen R Ariosa, Jane L Armstrong, Thierry Arnould, Ivica Arsov, Katsuhiko Asanuma, Valerie Askanas, Eric Asselin, Ryuichiro Atarashi, Sally S Atherton, Julie D Atkin, Laura D Attardi, Patrick Auberger, Georg Auburger, Laure Aurelian, Riccardo Autelli, Laura Avagliano, Maria Laura Avantaggiati, Limor Avrahami, Suresh Awale, Neelam Azad, Tiziana Bachetti, Jonathan M Backer, Dong-Hun Bae, Jae-Sung Bae, Ok-Nam Bae, Soo Han Bae, Eric H Baehrecke, Seung-Hoon Baek, Stephen Baghdiguian, Agnieszka Bagniewska-Zadworna, Hua Bai, Jie Bai, Xue-Yuan Bai, Yannick Bailly, Kithiganahalli Narayanaswamy Balaji, Walter Balduini, Andrea Ballabio, Rena Balzan, Rajkumar Banerjee, Gábor Bánhegyi, Haijun Bao, Benoit Barbeau, Maria D Barrachina, Esther Barreiro, Bonnie Bartel, Alberto Bartolomé, Diane C Bassham, Maria Teresa Bassi, Robert C Bast Jr, Alakananda Basu, Maria Teresa Batista, Henri Batoko, Maurizio Battino, Kyle Bauckman, Bradley L Baumgarner, K Ulrich Bayer, Rupert Beale, Jean-François Beaulieu, George R Beck Jr, Christoph Becker, J David Beckham, Pierre-André Bédard, Patrick J Bednarski, Thomas J Begley, Christian Behl, Christian Behrends, Georg Mn Behrens, Kevin E Behrns, Eloy Bejarano, Amine Belaid, Francesca Belleudi, Giovanni Bénard, Guy Berchem, Daniele Bergamaschi, Matteo Bergami, Ben Berkhout, Laura Berliocchi, Amélie Bernard, Monique Bernard, Francesca Bernassola, Anne Bertolotti, Amanda S Bess, Sébastien Besteiro, Saverio Bettuzzi, Savita Bhalla, Shalmoli Bhattacharyya, Sujit K Bhutia, Caroline Biagosch, Michele Wolfe Bianchi, Martine Biard-Piechaczyk, Viktor Billes, Claudia Bincoletto, Baris Bingol, Sara W Bird, Marc Bitoun, Ivana Bjedov, Craig Blackstone, Lionel Blanc, Guillermo A Blanco, Heidi Kiil Blomhoff, Emilio Boada-Romero, Stefan Böckler, Marianne Boes, Kathleen Boesze-Battaglia, Lawrence H Boise, Alessandra Bolino, Andrea Boman, Paolo Bonaldo, Matteo Bordi, Jürgen Bosch, Luis M Botana, Joelle Botti, German Bou, Marina Bouché, Marion Bouchecareilh, Marie-Josée Boucher, Michael E Boulton, Sebastien G Bouret, Patricia Boya, Michaël Boyer-Guittaut, Peter V Bozhkov, Nathan Brady, Vania Mm Braga, Claudio Brancolini, Gerhard H Braus, José M Bravo-San Pedro, Lisa A Brennan, Emery H Bresnick, Patrick Brest, Dave Bridges, Marie-Agnès Bringer, Marisa Brini, Glauber C Brito, Bertha Brodin, Paul S Brookes, Eric J Brown, Karen Brown, Hal E Broxmeyer, Alain Bruhat, Patricia Chakur Brum, John H Brumell, Nicola Brunetti-Pierri, Robert J Bryson-Richardson, Shilpa Buch, Alastair M Buchan, Hikmet Budak, Dmitry V Bulavin, Scott J Bultman, Geert Bultynck, Vladimir Bumbasirevic, Yan Burelle, Robert E Burke, Margit Burmeister, Peter Bütikofer, Laura Caberlotto, Ken Cadwell, Monika Cahova, Dongsheng Cai, Jingjing Cai, Qian Cai, Sara Calatayud, Nadine Camougrand, Michelangelo Campanella, Grant R Campbell, Matthew Campbell, Silvia Campello, Robin Candau, Isabella Caniggia, Lavinia Cantoni, Lizhi Cao, Allan B Caplan, Michele Caraglia, Claudio Cardinali, Sandra Morais Cardoso, Jennifer S Carew, Laura A Carleton, Cathleen R Carlin, Silvia Carloni, Sven R Carlsson, Didac Carmona-Gutierrez, Leticia Am Carneiro, Oliana Carnevali, Serena Carra, Alice Carrier, Bernadette Carroll, Caty Casas, Josefina Casas, Giuliana Cassinelli, Perrine Castets, Susana Castro-Obregon, Gabriella Cavallini, Isabella Ceccherini, Francesco Cecconi, Arthur I Cederbaum, Valentín Ceña, Simone Cenci, Claudia Cerella, Davide Cervia, Silvia Cetrullo, Hassan Chaachouay, Han-Jung Chae, Andrei S Chagin, Chee-Yin Chai, Gopal Chakrabarti, Georgios Chamilos, Edmond Yw Chan, Matthew Tv Chan, Dhyan Chandra, Pallavi Chandra, Chih-Peng Chang, Raymond Chuen-Chung Chang, Ta Yuan Chang, John C Chatham, Saurabh Chatterjee, Santosh Chauhan, Yongsheng Che, Michael E Cheetham, Rajkumar Cheluvappa, Chun-Jung Chen, Gang Chen, Guang-Chao Chen, Guoqiang Chen, Hongzhuan Chen, Jeff W Chen, Jian-Kang Chen, Min Chen, Mingzhou Chen, Peiwen Chen, Qi Chen, Quan Chen, Shang-Der Chen, Si Chen, Steve S-L Chen, Wei Chen, Wei-Jung Chen, Wen Qiang Chen, Wenli Chen, Xiangmei Chen, Yau-Hung Chen, Ye-Guang Chen, Yin Chen, Yingyu Chen, Yongshun Chen, Yu-Jen Chen, Yue-Qin Chen, Yujie Chen, Zhen Chen, Zhong Chen, Alan Cheng, Christopher Hk Cheng, Hua Cheng, Heesun Cheong, Sara Cherry, Jason Chesney, Chun Hei Antonio Cheung, Eric Chevet, Hsiang Cheng Chi, Sung-Gil Chi, Fulvio Chiacchiera, Hui-Ling Chiang, Roberto Chiarelli, Mario Chiariello, Marcello Chieppa, Lih-Shen Chin, Mario Chiong, Gigi Nc Chiu, Dong-Hyung Cho, Ssang-Goo Cho, William C Cho, Yong-Yeon Cho, Young-Seok Cho, Augustine Mk Choi, Eui-Ju Choi, Eun-Kyoung Choi, Jayoung Choi, Mary E Choi, Seung-Il Choi, Tsui-Fen Chou, Salem Chouaib, Divaker Choubey, Vinay Choubey, Kuan-Chih Chow, Kamal Chowdhury, Charleen T Chu, Tsung-Hsien Chuang, Taehoon Chun, Hyewon Chung, Taijoon Chung, Yuen-Li Chung, Yong-Joon Chwae, Valentina Cianfanelli, Roberto Ciarcia, Iwona A Ciechomska, Maria Rosa Ciriolo, Mara Cirone, Sofie Claerhout, Michael J Clague, Joan Clària, Peter Gh Clarke, Robert Clarke, Emilio Clementi, Cédric Cleyrat, Miriam Cnop, Eliana M Coccia, Tiziana Cocco, Patrice Codogno, Jörn Coers, Ezra Ew Cohen, David Colecchia, Luisa Coletto, Núria S Coll, Emma Colucci-Guyon, Sergio Comincini, Maria Condello, Katherine L Cook, Graham H Coombs, Cynthia D Cooper, J Mark Cooper, Isabelle Coppens, Maria Tiziana Corasaniti, Marco Corazzari, Ramon Corbalan, Elisabeth Corcelle-Termeau, Mario D Cordero, Cristina Corral-Ramos, Olga Corti, Andrea Cossarizza, Paola Costelli, Safia Costes, Susan L Cotman, Ana Coto-Montes, Sandra Cottet, Eduardo Couve, Lori R Covey, L Ashley Cowart, Jeffery S Cox, Fraser P Coxon, Carolyn B Coyne, Mark S Cragg, Rolf J Craven, Tiziana Crepaldi, Jose L Crespo, Alfredo Criollo, Valeria Crippa, Maria Teresa Cruz, Ana Maria Cuervo, Jose M Cuezva, Taixing Cui, Pedro R Cutillas, Mark J Czaja, Maria F Czyzyk-Krzeska, Ruben K Dagda, Uta Dahmen, Chunsun Dai, Wenjie Dai, Yun Dai, Kevin N Dalby, Luisa Dalla Valle, Guillaume Dalmasso, Marcello D'Amelio, Markus Damme, Arlette Darfeuille-Michaud, Catherine Dargemont, Victor M Darley-Usmar, Srinivasan Dasarathy, Biplab Dasgupta, Srikanta Dash, Crispin R Dass, Hazel Marie Davey, Lester M Davids, David Dávila, Roger J Davis, Ted M Dawson, Valina L Dawson, Paula Daza, Jackie de Belleroche, Paul de Figueiredo, Regina Celia Bressan Queiroz de Figueiredo, José de la Fuente, Luisa De Martino, Antonella De Matteis, Guido Ry De Meyer, Angelo De Milito, Mauro De Santi, Wanderley de Souza, Vincenzo De Tata, Daniela De Zio, Jayanta Debnath, Reinhard Dechant, Jean-Paul Decuypere, Shane Deegan, Benjamin Dehay, Barbara Del Bello, Dominic P Del Re, Régis Delage-Mourroux, Lea Md Delbridge, Louise Deldicque, Elizabeth Delorme-Axford, Yizhen Deng, Joern Dengjel, Melanie Denizot, Paul Dent, Channing J Der, Vojo Deretic, Benoît Derrien, Eric Deutsch, Timothy P Devarenne, Rodney J Devenish, Sabrina Di Bartolomeo, Nicola Di Daniele, Fabio Di Domenico, Alessia Di Nardo, Simone Di Paola, Antonio Di Pietro, Livia Di Renzo, Aaron DiAntonio, Guillermo Díaz-Araya, Ines Díaz-Laviada, Maria T Diaz-Meco, Javier Diaz-Nido, Chad A Dickey, Robert C Dickson, Marc Diederich, Paul Digard, Ivan Dikic, Savithrama P Dinesh-Kumar, Chan Ding, Wen-Xing Ding, Zufeng Ding, Luciana Dini, Jörg Hw Distler, Abhinav Diwan, Mojgan Djavaheri-Mergny, Kostyantyn Dmytruk, Renwick Cj Dobson, Volker Doetsch, Karol Dokladny, Svetlana Dokudovskaya, Massimo Donadelli, X Charlie Dong, Xiaonan Dong, Zheng Dong, Terrence M Donohue Jr, Kelly S Doran, Gabriella D'Orazi, Gerald W Dorn 2nd, Victor Dosenko, Sami Dridi, Liat Drucker, Jie Du, Li-Lin Du, Lihuan Du, André du Toit, Priyamvada Dua, Lei Duan, Pu Duann, Vikash Kumar Dubey, Michael R Duchen, Michel A Duchosal, Helene Duez, Isabelle Dugail, Verónica I Dumit, Mara C Duncan, Elaine A Dunlop, William A Dunn Jr, Nicolas Dupont, Luc Dupuis, Raúl V Durán, Thomas M Durcan, Stéphane Duvezin-Caubet, Umamaheswar Duvvuri, Vinay Eapen, Darius Ebrahimi-Fakhari, Arnaud Echard, Leopold Eckhart, Charles L Edelstein, Aimee L Edinger, Ludwig Eichinger, Tobias Eisenberg, Avital Eisenberg-Lerner, N Tony Eissa, Wafik S El-Deiry, Victoria El-Khoury, Zvulun Elazar, Hagit Eldar-Finkelman, Chris Jh Elliott, Enzo Emanuele, Urban Emmenegger, Nikolai Engedal, Anna-Mart Engelbrecht, Simone Engelender, Jorrit M Enserink, Ralf Erdmann, Jekaterina Erenpreisa, Rajaraman Eri, Jason L Eriksen, Andreja Erman, Ricardo Escalante, Eeva-Liisa Eskelinen, Lucile Espert, Lorena Esteban-Martínez, Thomas J Evans, Mario Fabri, Gemma Fabrias, Cinzia Fabrizi, Antonio Facchiano, Nils J Færgeman, Alberto Faggioni, W Douglas Fairlie, Chunhai Fan, Daping Fan, Jie Fan, Shengyun Fang, Manolis Fanto, Alessandro Fanzani, Thomas Farkas, Mathias Faure, Francois B Favier, Howard Fearnhead, Massimo Federici, Erkang Fei, Tania C Felizardo, Hua Feng, Yibin Feng, Yuchen Feng, Thomas A Ferguson, Álvaro F Fernández, Maite G Fernandez-Barrena, Jose C Fernandez-Checa, Arsenio Fernández-López, Martin E Fernandez-Zapico, Olivier Feron, Elisabetta Ferraro, Carmen Veríssima Ferreira-Halder, Laszlo Fesus, Ralph Feuer, Fabienne C Fiesel, Eduardo C Filippi-Chiela, Giuseppe Filomeni, Gian Maria Fimia, John H Fingert, Steven Finkbeiner, Toren Finkel, Filomena Fiorito, Paul B Fisher, Marc Flajolet, Flavio Flamigni, Oliver Florey, Salvatore Florio, R Andres Floto, Marco Folini, Carlo Follo, Edward A Fon, Francesco Fornai, Franco Fortunato, Alessandro Fraldi, Rodrigo Franco, Arnaud Francois, Aurélie François, Lisa B Frankel, Iain Dc Fraser, Norbert Frey, Damien G Freyssenet, Christian Frezza, Scott L Friedman, Daniel E Frigo, Dongxu Fu, José M Fuentes, Juan Fueyo, Yoshio Fujitani, Yuuki Fujiwara, Mikihiro Fujiya, Mitsunori Fukuda, Simone Fulda, Carmela Fusco, Bozena Gabryel, Matthias Gaestel, Philippe Gailly, Malgorzata Gajewska, Sehamuddin Galadari, Gad Galili, Inmaculada Galindo, Maria F Galindo, Giovanna Galliciotti, Lorenzo Galluzzi, Luca Galluzzi, Vincent Galy, Noor Gammoh, Sam Gandy, Anand K Ganesan, Swamynathan Ganesan, Ian G Ganley, Monique Gannagé, Fen-Biao Gao, Feng Gao, Jian-Xin Gao, Lorena García Nannig, Eleonora García Véscovi, Marina Garcia-Macía, Carmen Garcia-Ruiz, Abhishek D Garg, Pramod Kumar Garg, Ricardo Gargini, Nils Christian Gassen, Damián Gatica, Evelina Gatti, Julie Gavard, Evripidis Gavathiotis, Liang Ge, Pengfei Ge, Shengfang Ge, Po-Wu Gean, Vania Gelmetti, Armando A Genazzani, Jiefei Geng, Pascal Genschik, Lisa Gerner, Jason E Gestwicki, David A Gewirtz, Saeid Ghavami, Eric Ghigo, Debabrata Ghosh, Anna Maria Giammarioli, Francesca Giampieri, Claudia Giampietri, Alexandra Giatromanolaki, Derrick J Gibbings, Lara Gibellini, Spencer B Gibson, Vanessa Ginet, Antonio Giordano, Flaviano Giorgini, Elisa Giovannetti, Stephen E Girardin, Suzana Gispert, Sandy Giuliano, Candece L Gladson, Alvaro Glavic, Martin Gleave, Nelly Godefroy, Robert M Gogal Jr, Kuppan Gokulan, Gustavo H Goldman, Delia Goletti, Michael S Goligorsky, Aldrin V Gomes, Ligia C Gomes, Hernando Gomez, Candelaria Gomez-Manzano, Rubén Gómez-Sánchez, Dawit Ap Gonçalves, Ebru Goncu, Qingqiu Gong, Céline Gongora, Carlos B Gonzalez, Pedro Gonzalez-Alegre, Pilar Gonzalez-Cabo, Rosa Ana González-Polo, Ing Swie Goping, Carlos Gorbea, Nikolai V Gorbunov, Daphne R Goring, Adrienne M Gorman, Sharon M Gorski, Sandro Goruppi, Shino Goto-Yamada, Cecilia Gotor, Roberta A Gottlieb, Illana Gozes, Devrim Gozuacik, Yacine Graba, Martin Graef, Giovanna E Granato, Gary Dean Grant, Steven Grant, Giovanni Luca Gravina, Douglas R Green, Alexander Greenhough, Michael T Greenwood, Benedetto Grimaldi, Frédéric Gros, Charles Grose, Jean-Francois Groulx, Florian Gruber, Paolo Grumati, Tilman Grune, Jun-Lin Guan, Kun-Liang Guan, Barbara Guerra, Carlos Guillen, Kailash Gulshan, Jan Gunst, Chuanyong Guo, Lei Guo, Ming Guo, Wenjie Guo, Xu-Guang Guo, Andrea A Gust, Åsa B Gustafsson, Elaine Gutierrez, Maximiliano G Gutierrez, Ho-Shin Gwak, Albert Haas, James E Haber, Shinji Hadano, Monica Hagedorn, David R Hahn, Andrew J Halayko, Anne Hamacher-Brady, Kozo Hamada, Ahmed Hamai, Andrea Hamann, Maho Hamasaki, Isabelle Hamer, Qutayba Hamid, Ester M Hammond, Feng Han, Weidong Han, James T Handa, John A Hanover, Malene Hansen, Masaru Harada, Ljubica Harhaji-Trajkovic, J Wade Harper, Abdel Halim Harrath, Adrian L Harris, James Harris, Udo Hasler, Peter Hasselblatt, Kazuhisa Hasui, Robert G Hawley, Teresa S Hawley, Congcong He, Cynthia Y He, Fengtian He, Gu He, Rong-Rong He, Xian-Hui He, You-Wen He, Yu-Ying He, Joan K Heath, Marie-Josée Hébert, Robert A Heinzen, Gudmundur Vignir Helgason, Michael Hensel, Elizabeth P Henske, Chengtao Her, Paul K Herman, Agustín Hernández, Carlos Hernandez, Sonia Hernández-Tiedra, Claudio Hetz, P Robin Hiesinger, Katsumi Higaki, Sabine Hilfiker, Bradford G Hill, Joseph A Hill, William D Hill, Keisuke Hino, Daniel Hofius, Paul Hofman, Günter U Höglinger, Jörg Höhfeld, Marina K Holz, Yonggeun Hong, David A Hood, Jeroen Jm Hoozemans, Thorsten Hoppe, Chin Hsu, Chin-Yuan Hsu, Li-Chung Hsu, Dong Hu, Guochang Hu, Hong-Ming Hu, Hongbo Hu, Ming Chang Hu, Yu-Chen Hu, Zhuo-Wei Hu, Fang Hua, Ya Hua, Canhua Huang, Huey-Lan Huang, Kuo-How Huang, Kuo-Yang Huang, Shile Huang, Shiqian Huang, Wei-Pang Huang, Yi-Ran Huang, Yong Huang, Yunfei Huang, Tobias B Huber, Patricia Huebbe, Won-Ki Huh, Juha J Hulmi, Gang Min Hur, James H Hurley, Zvenyslava Husak, Sabah Na Hussain, Salik Hussain, Jung Jin Hwang, Seungmin Hwang, Thomas Is Hwang, Atsuhiro Ichihara, Yuzuru Imai, Carol Imbriano, Megumi Inomata, Takeshi Into, Valentina Iovane, Juan L Iovanna, Renato V Iozzo, Nancy Y Ip, Javier E Irazoqui, Pablo Iribarren, Yoshitaka Isaka, Aleksandra J Isakovic, Harry Ischiropoulos, Jeffrey S Isenberg, Mohammad Ishaq, Hiroyuki Ishida, Isao Ishii, Jane E Ishmael, Ciro Isidoro, Ken-Ichi Isobe, Erika Isono, Shohreh Issazadeh-Navikas, Koji Itahana, Eisuke Itakura, Andrei I Ivanov, Anand Krishnan V Iyer, José M Izquierdo, Yotaro Izumi, Valentina Izzo, Marja Jäättelä, Nadia Jaber, Daniel John Jackson, William T Jackson, Tony George Jacob, Thomas S Jacques, Chinnaswamy Jagannath, Ashish Jain, Nihar Ranjan Jana, Byoung Kuk Jang, Alkesh Jani, Bassam Janji, Paulo Roberto Jannig, Patric J Jansson, Steve Jean, Marina Jendrach, Ju-Hong Jeon, Niels Jessen, Eui-Bae Jeung, Kailiang Jia, Lijun Jia, Hong Jiang, Hongchi Jiang, Liwen Jiang, Teng Jiang, Xiaoyan Jiang, Xuejun Jiang, Xuejun Jiang, Ying Jiang, Yongjun Jiang, Alberto Jiménez, Cheng Jin, Hongchuan Jin, Lei Jin, Meiyan Jin, Shengkan Jin, Umesh Kumar Jinwal, Eun-Kyeong Jo, Terje Johansen, Daniel E Johnson, Gail Vw Johnson, James D Johnson, Eric Jonasch, Chris Jones, Leo Ab Joosten, Joaquin Jordan, Anna-Maria Joseph, Bertrand Joseph, Annie M Joubert, Dianwen Ju, Jingfang Ju, Hsueh-Fen Juan, Katrin Juenemann, Gábor Juhász, Hye Seung Jung, Jae U Jung, Yong-Keun Jung, Heinz Jungbluth, Matthew J Justice, Barry Jutten, Nadeem O Kaakoush, Kai Kaarniranta, Allen Kaasik, Tomohiro Kabuta, Bertrand Kaeffer, Katarina Kågedal, Alon Kahana, Shingo Kajimura, Or Kakhlon, Manjula Kalia, Dhan V Kalvakolanu, Yoshiaki Kamada, Konstantinos Kambas, Vitaliy O Kaminskyy, Harm H Kampinga, Mustapha Kandouz, Chanhee Kang, Rui Kang, Tae-Cheon Kang, Tomotake Kanki, Thirumala-Devi Kanneganti, Haruo Kanno, Anumantha G Kanthasamy, Marc Kantorow, Maria Kaparakis-Liaskos, Orsolya Kapuy, Vassiliki Karantza, Md Razaul Karim, Parimal Karmakar, Arthur Kaser, Susmita Kaushik, Thomas Kawula, A Murat Kaynar, Po-Yuan Ke, Zun-Ji Ke, John H Kehrl, Kate E Keller, Jongsook Kim Kemper, Anne K Kenworthy, Oliver Kepp, Andreas Kern, Santosh Kesari, David Kessel, Robin Ketteler, Isis do Carmo Kettelhut, Bilon Khambu, Muzamil Majid Khan, Vinoth Km Khandelwal, Sangeeta Khare, Juliann G Kiang, Amy A Kiger, Akio Kihara, Arianna L Kim, Cheol Hyeon Kim, Deok Ryong Kim, Do-Hyung Kim, Eung Kweon Kim, Hye Young Kim, Hyung-Ryong Kim, Jae-Sung Kim, Jeong Hun Kim, Jin Cheon Kim, Jin Hyoung Kim, Kwang Woon Kim, Michael D Kim, Moon-Moo Kim, Peter K Kim, Seong Who Kim, Soo-Youl Kim, Yong-Sun Kim, Yonghyun Kim, Adi Kimchi, Alec C Kimmelman, Tomonori Kimura, Jason S King, Karla Kirkegaard, Vladimir Kirkin, Lorrie A Kirshenbaum, Shuji Kishi, Yasuo Kitajima, Katsuhiko Kitamoto, Yasushi Kitaoka, Kaio Kitazato, Rudolf A Kley, Walter T Klimecki, Michael Klinkenberg, Jochen Klucken, Helene Knævelsrud, Erwin Knecht, Laura Knuppertz, Jiunn-Liang Ko, Satoru Kobayashi, Jan C Koch, Christelle Koechlin-Ramonatxo, Ulrich Koenig, Young Ho Koh, Katja Köhler, Sepp D Kohlwein, Masato Koike, Masaaki Komatsu, Eiki Kominami, Dexin Kong, Hee Jeong Kong, Eumorphia G Konstantakou, Benjamin T Kopp, Tamas Korcsmaros, Laura Korhonen, Viktor I Korolchuk, Nadya V Koshkina, Yanjun Kou, Michael I Koukourakis, Constantinos Koumenis, Attila L Kovács, Tibor Kovács, Werner J Kovacs, Daisuke Koya, Claudine Kraft, Dimitri Krainc, Helmut Kramer, Tamara Kravic-Stevovic, Wilhelm Krek, Carole Kretz-Remy, Roswitha Krick, Malathi Krishnamurthy, Janos Kriston-Vizi, Guido Kroemer, Michael C Kruer, Rejko Kruger, Nicholas T Ktistakis, Kazuyuki Kuchitsu, Christian Kuhn, Addanki Pratap Kumar, Anuj Kumar, Ashok Kumar, Deepak Kumar, Dhiraj Kumar, Rakesh Kumar, Sharad Kumar, Mondira Kundu, Hsing-Jien Kung, Atsushi Kuno, Sheng-Han Kuo, Jeff Kuret, Tino Kurz, Terry Kwok, Taeg Kyu Kwon, Yong Tae Kwon, Irene Kyrmizi, Albert R La Spada, Frank Lafont, Tim Lahm, Aparna Lakkaraju, Truong Lam, Trond Lamark, Steve Lancel, Terry H Landowski, Darius J R Lane, Jon D Lane, Cinzia Lanzi, Pierre Lapaquette, Louis R Lapierre, Jocelyn Laporte, Johanna Laukkarinen, Gordon W Laurie, Sergio Lavandero, Lena Lavie, Matthew J LaVoie, Betty Yuen Kwan Law, Helen Ka-Wai Law, Kelsey B Law, Robert Layfield, Pedro A Lazo, Laurent Le Cam, Karine G Le Roch, Hervé Le Stunff, Vijittra Leardkamolkarn, Marc Lecuit, Byung-Hoon Lee, Che-Hsin Lee, Erinna F Lee, Gyun Min Lee, He-Jin Lee, Hsinyu Lee, Jae Keun Lee, Jongdae Lee, Ju-Hyun Lee, Jun Hee Lee, Michael Lee, Myung-Shik Lee, Patty J Lee, Sam W Lee, Seung-Jae Lee, Shiow-Ju Lee, Stella Y Lee, Sug Hyung Lee, Sung Sik Lee, Sung-Joon Lee, Sunhee Lee, Ying-Ray Lee, Yong J Lee, Young H Lee, Christiaan Leeuwenburgh, Sylvain Lefort, Renaud Legouis, Jinzhi Lei, Qun-Ying Lei, David A Leib, Gil Leibowitz, Istvan Lekli, Stéphane D Lemaire, John J Lemasters, Marius K Lemberg, Antoinette Lemoine, Shuilong Leng, Guido Lenz, Paola Lenzi, Lilach O Lerman, Daniele Lettieri Barbato, Julia I-Ju Leu, Hing Y Leung, Beth Levine, Patrick A Lewis, Frank Lezoualc'h, Chi Li, Faqiang Li, Feng-Jun Li, Jun Li, Ke Li, Lian Li, Min Li, Min Li, Qiang Li, Rui Li, Sheng Li, Wei Li, Wei Li, Xiaotao Li, Yumin Li, Jiqin Lian, Chengyu Liang, Qiangrong Liang, Yulin Liao, Joana Liberal, Pawel P Liberski, Pearl Lie, Andrew P Lieberman, Hyunjung Jade Lim, Kah-Leong Lim, Kyu Lim, Raquel T Lima, Chang-Shen Lin, Chiou-Feng Lin, Fang Lin, Fangming Lin, Fu-Cheng Lin, Kui Lin, Kwang-Huei Lin, Pei-Hui Lin, Tianwei Lin, Wan-Wan Lin, Yee-Shin Lin, Yong Lin, Rafael Linden, Dan Lindholm, Lisa M Lindqvist, Paul Lingor, Andreas Linkermann, Lance A Liotta, Marta M Lipinski, Vitor A Lira, Michael P Lisanti, Paloma B Liton, Bo Liu, Chong Liu, Chun-Feng Liu, Fei Liu, Hung-Jen Liu, Jianxun Liu, Jing-Jing Liu, Jing-Lan Liu, Ke Liu, Leyuan Liu, Liang Liu, Quentin Liu, Rong-Yu Liu, Shiming Liu, Shuwen Liu, Wei Liu, Xian-De Liu, Xiangguo Liu, Xiao-Hong Liu, Xinfeng Liu, Xu Liu, Xueqin Liu, Yang Liu, Yule Liu, Zexian Liu, Zhe Liu, Juan P Liuzzi, Gérard Lizard, Mila Ljujic, Irfan J Lodhi, Susan E Logue, Bal L Lokeshwar, Yun Chau Long, Sagar Lonial, Benjamin Loos, Carlos López-Otín, Cristina López-Vicario, Mar Lorente, Philip L Lorenzi, Péter Lõrincz, Marek Los, Michael T Lotze, Penny E Lovat, Binfeng Lu, Bo Lu, Jiahong Lu, Qing Lu, She-Min Lu, Shuyan Lu, Yingying Lu, Frédéric Luciano, Shirley Luckhart, John Milton Lucocq, Paula Ludovico, Aurelia Lugea, Nicholas W Lukacs, Julian J Lum, Anders H Lund, Honglin Luo, Jia Luo, Shouqing Luo, Claudio Luparello, Timothy Lyons, Jianjie Ma, Yi Ma, Yong Ma, Zhenyi Ma, Juliano Machado, Glaucia M Machado-Santelli, Fernando Macian, Gustavo C MacIntosh, Jeffrey P MacKeigan, Kay F Macleod, John D MacMicking, Lee Ann MacMillan-Crow, Frank Madeo, Muniswamy Madesh, Julio Madrigal-Matute, Akiko Maeda, Tatsuya Maeda, Gustavo Maegawa, Emilia Maellaro, Hannelore Maes, Marta Magariños, Kenneth Maiese, Tapas K Maiti, Luigi Maiuri, Maria Chiara Maiuri, Carl G Maki, Roland Malli, Walter Malorni, Alina Maloyan, Fathia Mami-Chouaib, Na Man, Joseph D Mancias, Eva-Maria Mandelkow, Michael A Mandell, Angelo A Manfredi, Serge N Manié, Claudia Manzoni, Kai Mao, Zixu Mao, Zong-Wan Mao, Philippe Marambaud, Anna Maria Marconi, Zvonimir Marelja, Gabriella Marfe, Marta Margeta, Eva Margittai, Muriel Mari, Francesca V Mariani, Concepcio Marin, Sara Marinelli, Guillermo Mariño, Ivanka Markovic, Rebecca Marquez, Alberto M Martelli, Sascha Martens, Katie R Martin, Seamus J Martin, Shaun Martin, Miguel A Martin-Acebes, Paloma Martín-Sanz, Camille Martinand-Mari, Wim Martinet, Jennifer Martinez, Nuria Martinez-Lopez, Ubaldo Martinez-Outschoorn, Moisés Martínez-Velázquez, Marta Martinez-Vicente, Waleska Kerllen Martins, Hirosato Mashima, James A Mastrianni, Giuseppe Matarese, Paola Matarrese, Roberto Mateo, Satoaki Matoba, Naomichi Matsumoto, Takehiko Matsushita, Akira Matsuura, Takeshi Matsuzawa, Mark P Mattson, Soledad Matus, Norma Maugeri, Caroline Mauvezin, Andreas Mayer, Dusica Maysinger, Guillermo D Mazzolini, Mary Kate McBrayer, Kimberly McCall, Craig McCormick, Gerald M McInerney, Skye C McIver, Sharon McKenna, John J McMahon, Iain A McNeish, Fatima Mechta-Grigoriou, Jan Paul Medema, Diego L Medina, Klara Megyeri, Maryam Mehrpour, Jawahar L Mehta, Yide Mei, Ute-Christiane Meier, Alfred J Meijer, Alicia Meléndez, Gerry Melino, Sonia Melino, Edesio Jose Tenorio de Melo, Maria A Mena, Marc D Meneghini, Javier A Menendez, Regina Menezes, Liesu Meng, Ling-Hua Meng, Songshu Meng, Rossella Menghini, A Sue Menko, Rubem Fs Menna-Barreto, Manoj B Menon, Marco A Meraz-Ríos, Giuseppe Merla, Luciano Merlini, Angelica M Merlot, Andreas Meryk, Stefania Meschini, Joel N Meyer, Man-Tian Mi, Chao-Yu Miao, Lucia Micale, Simon Michaeli, Carine Michiels, Anna Rita Migliaccio, Anastasia Susie Mihailidou, Dalibor Mijaljica, Katsuhiko Mikoshiba, Enrico Milan, Leonor Miller-Fleming, Gordon B Mills, Ian G Mills, Georgia Minakaki, Berge A Minassian, Xiu-Fen Ming, Farida Minibayeva, Elena A Minina, Justine D Mintern, Saverio Minucci, Antonio Miranda-Vizuete, Claire H Mitchell, Shigeki Miyamoto, Keisuke Miyazawa, Noboru Mizushima, Katarzyna Mnich, Baharia Mograbi, Simin Mohseni, Luis Ferreira Moita, Marco Molinari, Maurizio Molinari, Andreas Buch Møller, Bertrand Mollereau, Faustino Mollinedo, Marco Mongillo, Martha M Monick, Serena Montagnaro, Craig Montell, Darren J Moore, Michael N Moore, Rodrigo Mora-Rodriguez, Paula I Moreira, Etienne Morel, Maria Beatrice Morelli, Sandra Moreno, Michael J Morgan, Arnaud Moris, Yuji Moriyasu, Janna L Morrison, Lynda A Morrison, Eugenia Morselli, Jorge Moscat, Pope L Moseley, Serge Mostowy, Elisa Motori, Denis Mottet, Jeremy C Mottram, Charbel E-H Moussa, Vassiliki E Mpakou, Hasan Mukhtar, Jean M Mulcahy Levy, Sylviane Muller, Raquel Muñoz-Moreno, Cristina Muñoz-Pinedo, Christian Münz, Maureen E Murphy, James T Murray, Aditya Murthy, Indira U Mysorekar, Ivan R Nabi, Massimo Nabissi, Gustavo A Nader, Yukitoshi Nagahara, Yoshitaka Nagai, Kazuhiro Nagata, Anika Nagelkerke, Péter Nagy, Samisubbu R Naidu, Sreejayan Nair, Hiroyasu Nakano, Hitoshi Nakatogawa, Meera Nanjundan, Gennaro Napolitano, Naweed I Naqvi, Roberta Nardacci, Derek P Narendra, Masashi Narita, Anna Chiara Nascimbeni, Ramesh Natarajan, Luiz C Navegantes, Steffan T Nawrocki, Taras Y Nazarko, Volodymyr Y Nazarko, Thomas Neill, Luca M Neri, Mihai G Netea, Romana T Netea-Maier, Bruno M Neves, Paul A Ney, Ioannis P Nezis, Hang Tt Nguyen, Huu Phuc Nguyen, Anne-Sophie Nicot, Hilde Nilsen, Per Nilsson, Mikio Nishimura, Ichizo Nishino, Mireia Niso-Santano, Hua Niu, Ralph A Nixon, Vincent Co Njar, Takeshi Noda, Angelika A Noegel, Elsie Magdalena Nolte, Erik Norberg, Koenraad K Norga, Sakineh Kazemi Noureini, Shoji Notomi, Lucia Notterpek, Karin Nowikovsky, Nobuyuki Nukina, Thorsten Nürnberger, Valerie B O'Donnell, Tracey O'Donovan, Peter J O'Dwyer, Ina Oehme, Clara L Oeste, Michinaga Ogawa, Besim Ogretmen, Yuji Ogura, Young J Oh, Masaki Ohmuraya, Takayuki Ohshima, Rani Ojha, Koji Okamoto, Toshiro Okazaki, F Javier Oliver, Karin Ollinger, Stefan Olsson, Daniel P Orban, Paulina Ordonez, Idil Orhon, Laszlo Orosz, Eyleen J O'Rourke, Helena Orozco, Angel L Ortega, Elena Ortona, Laura D Osellame, Junko Oshima, Shigeru Oshima, Heinz D Osiewacz, Takanobu Otomo, Kinya Otsu, Jing-Hsiung James Ou, Tiago F Outeiro, Dong-Yun Ouyang, Hongjiao Ouyang, Michael Overholtzer, Michelle A Ozbun, P Hande Ozdinler, Bulent Ozpolat, Consiglia Pacelli, Paolo Paganetti, Guylène Page, Gilles Pages, Ugo Pagnini, Beata Pajak, Stephen C Pak, Karolina Pakos-Zebrucka, Nazzy Pakpour, Zdena Palková, Francesca Palladino, Kathrin Pallauf, Nicolas Pallet, Marta Palmieri, Søren R Paludan, Camilla Palumbo, Silvia Palumbo, Olatz Pampliega, Hongming Pan, Wei Pan, Theocharis Panaretakis, Aseem Pandey, Areti Pantazopoulou, Zuzana Papackova, Daniela L Papademetrio, Issidora Papassideri, Alessio Papini, Nirmala Parajuli, Julian Pardo, Vrajesh V Parekh, Giancarlo Parenti, Jong-In Park, Junsoo Park, Ohkmae K Park, Roy Parker, Rosanna Parlato, Jan B Parys, Katherine R Parzych, Jean-Max Pasquet, Benoit Pasquier, Kishore Bs Pasumarthi, Daniel Patschan, Cam Patterson, Sophie Pattingre, Scott Pattison, Arnim Pause, Hermann Pavenstädt, Flaminia Pavone, Zully Pedrozo, Fernando J Peña, Miguel A Peñalva, Mario Pende, Jianxin Peng, Fabio Penna, Josef M Penninger, Anna Pensalfini, Salvatore Pepe, Gustavo Js Pereira, Paulo C Pereira, Verónica Pérez-de la Cruz, María Esther Pérez-Pérez, Diego Pérez-Rodríguez, Dolores Pérez-Sala, Celine Perier, Andras Perl, David H Perlmutter, Ida Perrotta, Shazib Pervaiz, Maija Pesonen, Jeffrey E Pessin, Godefridus J Peters, Morten Petersen, Irina Petrache, Basil J Petrof, Goran Petrovski, James M Phang, Mauro Piacentini, Marina Pierdominici, Philippe Pierre, Valérie Pierrefite-Carle, Federico Pietrocola, Felipe X Pimentel-Muiños, Mario Pinar, Benjamin Pineda, Ronit Pinkas-Kramarski, Marcello Pinti, Paolo Pinton, Bilal Piperdi, James M Piret, Leonidas C Platanias, Harald W Platta, Edward D Plowey, Stefanie Pöggeler, Marc Poirot, Peter Polčic, Angelo Poletti, Audrey H Poon, Hana Popelka, Blagovesta Popova, Izabela Poprawa, Shibu M Poulose, Joanna Poulton, Scott K Powers, Ted Powers, Mercedes Pozuelo-Rubio, Krisna Prak, Reinhild Prange, Mark Prescott, Muriel Priault, Sharon Prince, Richard L Proia, Tassula Proikas-Cezanne, Holger Prokisch, Vasilis J Promponas, Karin Przyklenk, Rosa Puertollano, Subbiah Pugazhenthi, Luigi Puglielli, Aurora Pujol, Julien Puyal, Dohun Pyeon, Xin Qi, Wen-Bin Qian, Zheng-Hong Qin, Yu Qiu, Ziwei Qu, Joe Quadrilatero, Frederick Quinn, Nina Raben, Hannah Rabinowich, Flavia Radogna, Michael J Ragusa, Mohamed Rahmani, Komal Raina, Sasanka Ramanadham, Rajagopal Ramesh, Abdelhaq Rami, Sarron Randall-Demllo, Felix Randow, Hai Rao, V Ashutosh Rao, Blake B Rasmussen, Tobias M Rasse, Edward A Ratovitski, Pierre-Emmanuel Rautou, Swapan K Ray, Babak Razani, Bruce H Reed, Fulvio Reggiori, Markus Rehm, Andreas S Reichert, Theo Rein, David J Reiner, Eric Reits, Jun Ren, Xingcong Ren, Maurizio Renna, Jane Eb Reusch, Jose L Revuelta, Leticia Reyes, Alireza R Rezaie, Robert I Richards, Des R Richardson, Clémence Richetta, Michael A Riehle, Bertrand H Rihn, Yasuko Rikihisa, Brigit E Riley, Gerald Rimbach, Maria Rita Rippo, Konstantinos Ritis, Federica Rizzi, Elizete Rizzo, Peter J Roach, Jeffrey Robbins, Michel Roberge, Gabriela Roca, Maria Carmela Roccheri, Sonia Rocha, Cecilia Mp Rodrigues, Clara I Rodríguez, Santiago Rodriguez de Cordoba, Natalia Rodriguez-Muela, Jeroen Roelofs, Vladimir V Rogov, Troy T Rohn, Bärbel Rohrer, Davide Romanelli, Luigina Romani, Patricia Silvia Romano, M Isabel G Roncero, Jose Luis Rosa, Alicia Rosello, Kirill V Rosen, Philip Rosenstiel, Magdalena Rost-Roszkowska, Kevin A Roth, Gael Roué, Mustapha Rouis, Kasper M Rouschop, Daniel T Ruan, Diego Ruano, David C Rubinsztein, Edmund B Rucker 3rd, Assaf Rudich, Emil Rudolf, Ruediger Rudolf, Markus A Ruegg, Carmen Ruiz-Roldan, Avnika Ashok Ruparelia, Paola Rusmini, David W Russ, Gian Luigi Russo, Giuseppe Russo, Rossella Russo, Tor Erik Rusten, Victoria Ryabovol, Kevin M Ryan, Stefan W Ryter, David M Sabatini, Michael Sacher, Carsten Sachse, Michael N Sack, Junichi Sadoshima, Paul Saftig, Ronit Sagi-Eisenberg, Sumit Sahni, Pothana Saikumar, Tsunenori Saito, Tatsuya Saitoh, Koichi Sakakura, Machiko Sakoh-Nakatogawa, Yasuhito Sakuraba, María Salazar-Roa, Paolo Salomoni, Ashok K Saluja, Paul M Salvaterra, Rosa Salvioli, Afshin Samali, Anthony Mj Sanchez, José A Sánchez-Alcázar, Ricardo Sanchez-Prieto, Marco Sandri, Miguel A Sanjuan, Stefano Santaguida, Laura Santambrogio, Giorgio Santoni, Claudia Nunes Dos Santos, Shweta Saran, Marco Sardiello, Graeme Sargent, Pallabi Sarkar, Sovan Sarkar, Maria Rosa Sarrias, Minnie M Sarwal, Chihiro Sasakawa, Motoko Sasaki, Miklos Sass, Ken Sato, Miyuki Sato, Joseph Satriano, Niramol Savaraj, Svetlana Saveljeva, Liliana Schaefer, Ulrich E Schaible, Michael Scharl, Hermann M Schatzl, Randy Schekman, Wiep Scheper, Alfonso Schiavi, Hyman M Schipper, Hana Schmeisser, Jens Schmidt, Ingo Schmitz, Bianca E Schneider, E Marion Schneider, Jaime L Schneider, Eric A Schon, Miriam J Schönenberger, Axel H Schönthal, Daniel F Schorderet, Bernd Schröder, Sebastian Schuck, Ryan J Schulze, Melanie Schwarten, Thomas L Schwarz, Sebastiano Sciarretta, Kathleen Scotto, A Ivana Scovassi, Robert A Screaton, Mark Screen, Hugo Seca, Simon Sedej, Laura Segatori, Nava Segev, Per O Seglen, Jose M Seguí-Simarro, Juan Segura-Aguilar, Ekihiro Seki, Christian Sell, Iban Seiliez, Clay F Semenkovich, Gregg L Semenza, Utpal Sen, Andreas L Serra, Ana Serrano-Puebla, Hiromi Sesaki, Takao Setoguchi, Carmine Settembre, John J Shacka, Ayesha N Shajahan-Haq, Irving M Shapiro, Shweta Sharma, Hua She, C-K James Shen, Chiung-Chyi Shen, Han-Ming Shen, Sanbing Shen, Weili Shen, Rui Sheng, Xianyong Sheng, Zu-Hang Sheng, Trevor G Shepherd, Junyan Shi, Qiang Shi, Qinghua Shi, Yuguang Shi, Shusaku Shibutani, Kenichi Shibuya, Yoshihiro Shidoji, Jeng-Jer Shieh, Chwen-Ming Shih, Yohta Shimada, Shigeomi Shimizu, Dong Wook Shin, Mari L Shinohara, Michiko Shintani, Takahiro Shintani, Tetsuo Shioi, Ken Shirabe, Ronit Shiri-Sverdlov, Orian Shirihai, Gordon C Shore, Chih-Wen Shu, Deepak Shukla, Andriy A Sibirny, Valentina Sica, Christina J Sigurdson, Einar M Sigurdsson, Puran Singh Sijwali, Beata Sikorska, Wilian A Silveira, Sandrine Silvente-Poirot, Gary A Silverman, Jan Simak, Thomas Simmet, Anna Katharina Simon, Hans-Uwe Simon, Cristiano Simone, Matias Simons, Anne Simonsen, Rajat Singh, Shivendra V Singh, Shrawan K Singh, Debasish Sinha, Sangita Sinha, Frank A Sinicrope, Agnieszka Sirko, Kapil Sirohi, Balindiwe Jn Sishi, Annie Sittler, Parco M Siu, Efthimios Sivridis, Anna Skwarska, Ruth Slack, Iva Slaninová, Nikolai Slavov, Soraya S Smaili, Keiran Sm Smalley, Duncan R Smith, Stefaan J Soenen, Scott A Soleimanpour, Anita Solhaug, Kumaravel Somasundaram, Jin H Son, Avinash Sonawane, Chunjuan Song, Fuyong Song, Hyun Kyu Song, Ju-Xian Song, Wei Song, Kai Y Soo, Anil K Sood, Tuck Wah Soong, Virawudh Soontornniyomkij, Maurizio Sorice, Federica Sotgia, David R Soto-Pantoja, Areechun Sotthibundhu, Maria João Sousa, Herman P Spaink, Paul N Span, Anne Spang, Janet D Sparks, Peter G Speck, Stephen A Spector, Claudia D Spies, Wolfdieter Springer, Daret St Clair, Alessandra Stacchiotti, Bart Staels, Michael T Stang, Daniel T Starczynowski, Petro Starokadomskyy, Clemens Steegborn, John W Steele, Leonidas Stefanis, Joan Steffan, Christine M Stellrecht, Harald Stenmark, Tomasz M Stepkowski, Stęphan T Stern, Craig Stevens, Brent R Stockwell, Veronika Stoka, Zuzana Storchova, Björn Stork, Vassilis Stratoulias, Dimitrios J Stravopodis, Pavel Strnad, Anne Marie Strohecker, Anna-Lena Ström, Per Stromhaug, Jiri Stulik, Yu-Xiong Su, Zhaoliang Su, Carlos S Subauste, Srinivasa Subramaniam, Carolyn M Sue, Sang Won Suh, Xinbing Sui, Supawadee Sukseree, David Sulzer, Fang-Lin Sun, Jiaren Sun, Jun Sun, Shi-Yong Sun, Yang Sun, Yi Sun, Yingjie Sun, Vinod Sundaramoorthy, Joseph Sung, Hidekazu Suzuki, Kuninori Suzuki, Naoki Suzuki, Tadashi Suzuki, Yuichiro J Suzuki, Michele S Swanson, Charles Swanton, Karl Swärd, Ghanshyam Swarup, Sean T Sweeney, Paul W Sylvester, Zsuzsanna Szatmari, Eva Szegezdi, Peter W Szlosarek, Heinrich Taegtmeyer, Marco Tafani, Emmanuel Taillebourg, Stephen Wg Tait, Krisztina Takacs-Vellai, Yoshinori Takahashi, Szabolcs Takáts, Genzou Takemura, Nagio Takigawa, Nicholas J Talbot, Elena Tamagno, Jerome Tamburini, Cai-Ping Tan, Lan Tan, Mei Lan Tan, Ming Tan, Yee-Joo Tan, Keiji Tanaka, Masaki Tanaka, Daolin Tang, Dingzhong Tang, Guomei Tang, Isei Tanida, Kunikazu Tanji, Bakhos A Tannous, Jose A Tapia, Inmaculada Tasset-Cuevas, Marc Tatar, Iman Tavassoly, Nektarios Tavernarakis, Allen Taylor, Graham S Taylor, Gregory A Taylor, J Paul Taylor, Mark J Taylor, Elena V Tchetina, Andrew R Tee, Fatima Teixeira-Clerc, Sucheta Telang, Tewin Tencomnao, Ba-Bie Teng, Ru-Jeng Teng, Faraj Terro, Gianluca Tettamanti, Arianne L Theiss, Anne E Theron, Kelly Jean Thomas, Marcos P Thomé, Paul G Thomes, Andrew Thorburn, Jeremy Thorner, Thomas Thum, Michael Thumm, Teresa Lm Thurston, Ling Tian, Andreas Till, Jenny Pan-Yun Ting, Vladimir I Titorenko, Lilach Toker, Stefano Toldo, Sharon A Tooze, Ivan Topisirovic, Maria Lyngaas Torgersen, Liliana Torosantucci, Alicia Torriglia, Maria Rosaria Torrisi, Cathy Tournier, Roberto Towns, Vladimir Trajkovic, Leonardo H Travassos, Gemma Triola, Durga Nand Tripathi, Daniela Trisciuoglio, Rodrigo Troncoso, Ioannis P Trougakos, Anita C Truttmann, Kuen-Jer Tsai, Mario P Tschan, Yi-Hsin Tseng, Takayuki Tsukuba, Allan Tsung, Andrey S Tsvetkov, Shuiping Tu, Hsing-Yu Tuan, Marco Tucci, David A Tumbarello, Boris Turk, Vito Turk, Robin Fb Turner, Anders A Tveita, Suresh C Tyagi, Makoto Ubukata, Yasuo Uchiyama, Andrej Udelnow, Takashi Ueno, Midori Umekawa, Rika Umemiya-Shirafuji, Benjamin R Underwood, Christian Ungermann, Rodrigo P Ureshino, Ryo Ushioda, Vladimir N Uversky, Néstor L Uzcátegui, Thomas Vaccari, Maria I Vaccaro, Libuše Váchová, Helin Vakifahmetoglu-Norberg, Rut Valdor, Enza Maria Valente, Francois Vallette, Angela M Valverde, Greet Van den Berghe, Ludo Van Den Bosch, Gijs R van den Brink, F Gisou van der Goot, Ida J van der Klei, Luc Jw van der Laan, Wouter G van Doorn, Marjolein van Egmond, Kenneth L van Golen, Luc Van Kaer, Menno van Lookeren Campagne, Peter Vandenabeele, Wim Vandenberghe, Ilse Vanhorebeek, Isabel Varela-Nieto, M Helena Vasconcelos, Radovan Vasko, Demetrios G Vavvas, Ignacio Vega-Naredo, Guillermo Velasco, Athanassios D Velentzas, Panagiotis D Velentzas, Tibor Vellai, Edo Vellenga, Mikkel Holm Vendelbo, Kartik Venkatachalam, Natascia Ventura, Salvador Ventura, Patrícia St Veras, Mireille Verdier, Beata G Vertessy, Andrea Viale, Michel Vidal, Helena L A Vieira, Richard D Vierstra, Nadarajah Vigneswaran, Neeraj Vij, Miquel Vila, Margarita Villar, Victor H Villar, Joan Villarroya, Cécile Vindis, Giampietro Viola, Maria Teresa Viscomi, Giovanni Vitale, Dan T Vogl, Olga V Voitsekhovskaja, Clarissa von Haefen, Karin von Schwarzenberg, Daniel E Voth, Valérie Vouret-Craviari, Kristina Vuori, Jatin M Vyas, Christian Waeber, Cheryl Lyn Walker, Mark J Walker, Jochen Walter, Lei Wan, Xiangbo Wan, Bo Wang, Caihong Wang, Chao-Yung Wang, Chengshu Wang, Chenran Wang, Chuangui Wang, Dong Wang, Fen Wang, Fuxin Wang, Guanghui Wang, Hai-Jie Wang, Haichao Wang, Hong-Gang Wang, Hongmin Wang, Horng-Dar Wang, Jing Wang, Junjun Wang, Mei Wang, Mei-Qing Wang, Pei-Yu Wang, Peng Wang, Richard C Wang, Shuo Wang, Ting-Fang Wang, Xian Wang, Xiao-Jia Wang, Xiao-Wei Wang, Xin Wang, Xuejun Wang, Yan Wang, Yanming Wang, Ying Wang, Ying-Jan Wang, Yipeng Wang, Yu Wang, Yu Tian Wang, Yuqing Wang, Zhi-Nong Wang, Pablo Wappner, Carl Ward, Diane McVey Ward, Gary Warnes, Hirotaka Watada, Yoshihisa Watanabe, Kei Watase, Timothy E Weaver, Colin D Weekes, Jiwu Wei, Thomas Weide, Conrad C Weihl, Günther Weindl, Simone Nardin Weis, Longping Wen, Xin Wen, Yunfei Wen, Benedikt Westermann, Cornelia M Weyand, Anthony R White, Eileen White, J Lindsay Whitton, Alexander J Whitworth, Joëlle Wiels, Franziska Wild, Manon E Wildenberg, Tom Wileman, Deepti Srinivas Wilkinson, Simon Wilkinson, Dieter Willbold, Chris Williams, Katherine Williams, Peter R Williamson, Konstanze F Winklhofer, Steven S Witkin, Stephanie E Wohlgemuth, Thomas Wollert, Ernst J Wolvetang, Esther Wong, G William Wong, Richard W Wong, Vincent Kam Wai Wong, Elizabeth A Woodcock, Karen L Wright, Chunlai Wu, Defeng Wu, Gen Sheng Wu, Jian Wu, Junfang Wu, Mian Wu, Min Wu, Shengzhou Wu, William Kk Wu, Yaohua Wu, Zhenlong Wu, Cristina Pr Xavier, Ramnik J Xavier, Gui-Xian Xia, Tian Xia, Weiliang Xia, Yong Xia, Hengyi Xiao, Jian Xiao, Shi Xiao, Wuhan Xiao, Chuan-Ming Xie, Zhiping Xie, Zhonglin Xie, Maria Xilouri, Yuyan Xiong, Chuanshan Xu, Congfeng Xu, Feng Xu, Haoxing Xu, Hongwei Xu, Jian Xu, Jianzhen Xu, Jinxian Xu, Liang Xu, Xiaolei Xu, Yangqing Xu, Ye Xu, Zhi-Xiang Xu, Ziheng Xu, Yu Xue, Takahiro Yamada, Ai Yamamoto, Koji Yamanaka, Shunhei Yamashina, Shigeko Yamashiro, Bing Yan, Bo Yan, Xianghua Yan, Zhen Yan, Yasuo Yanagi, Dun-Sheng Yang, Jin-Ming Yang, Liu Yang, Minghua Yang, Pei-Ming Yang, Peixin Yang, Qian Yang, Wannian Yang, Wei Yuan Yang, Xuesong Yang, Yi Yang, Ying Yang, Zhifen Yang, Zhihong Yang, Meng-Chao Yao, Pamela J Yao, Xiaofeng Yao, Zhenyu Yao, Zhiyuan Yao, Linda S Yasui, Mingxiang Ye, Barry Yedvobnick, Behzad Yeganeh, Elizabeth S Yeh, Patricia L Yeyati, Fan Yi, Long Yi, Xiao-Ming Yin, Calvin K Yip, Yeong-Min Yoo, Young Hyun Yoo, Seung-Yong Yoon, Ken-Ichi Yoshida, Tamotsu Yoshimori, Ken H Young, Huixin Yu, Jane J Yu, Jin-Tai Yu, Jun Yu, Li Yu, W Haung Yu, Xiao-Fang Yu, Zhengping Yu, Junying Yuan, Zhi-Min Yuan, Beatrice Yjt Yue, Jianbo Yue, Zhenyu Yue, David N Zacks, Eldad Zacksenhaus, Nadia Zaffaroni, Tania Zaglia, Zahra Zakeri, Vincent Zecchini, Jinsheng Zeng, Min Zeng, Qi Zeng, Antonis S Zervos, Donna D Zhang, Fan Zhang, Guo Zhang, Guo-Chang Zhang, Hao Zhang, Hong Zhang, Hong Zhang, Hongbing Zhang, Jian Zhang, Jian Zhang, Jiangwei Zhang, Jianhua Zhang, Jing-Pu Zhang, Li Zhang, Lin Zhang, Lin Zhang, Long Zhang, Ming-Yong Zhang, Xiangnan Zhang, Xu Dong Zhang, Yan Zhang, Yang Zhang, Yanjin Zhang, Yingmei Zhang, Yunjiao Zhang, Mei Zhao, Wei-Li Zhao, Xiaonan Zhao, Yan G Zhao, Ying Zhao, Yongchao Zhao, Yu-Xia Zhao, Zhendong Zhao, Zhizhuang J Zhao, Dexian Zheng, Xi-Long Zheng, Xiaoxiang Zheng, Boris Zhivotovsky, Qing Zhong, Guang-Zhou Zhou, Guofei Zhou, Huiping Zhou, Shu-Feng Zhou, Xu-Jie Zhou, Hongxin Zhu, Hua Zhu, Wei-Guo Zhu, Wenhua Zhu, Xiao-Feng Zhu, Yuhua Zhu, Shi-Mei Zhuang, Xiaohong Zhuang, Elio Ziparo, Christos E Zois, Teresa Zoladek, Wei-Xing Zong, Antonio Zorzano, Susu M Zughaier

    Autophagy   12 ( 1 )   1 - 222   2016年

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1080/15548627.2015.1100356

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  • Autophagic vacuoles in cardiomyocytes of dilated cardiomyopathy with initially decompensated heart failure predict improved prognosis. 査読 国際誌

    Tsunenori Saito, Kuniya Asai, Shigeru Sato, Meiso Hayashi, Akiko Adachi, Yoshihiro Sasaki, Hitoshi Takano, Kyoichi Mizuno, Wataru Shimizu

    Autophagy   12 ( 3 )   579 - 87   2016年

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    記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：TAYLOR & FRANCIS INC  

    Autophagy is a process of bulk protein degradation and organelle turnover, and is a current therapeutic target in several diseases. The present study aimed to clarify the significance of myocardial autophagy of patients with dilated cardiomyopathy (DCM). Left ventricular endomyocardial biopsy was performed in 250 consecutive patients with DCM (54.9±13.9 years; male, 79%), initially presenting with decompensated heart failure (HF). The association of these findings with HF mortality or recurrence was examined. Myofilament changes, which are apparent in the degenerated cardiomyocytes of DCM, were recognized in 164 patients (66%), and autophagic vacuoles in cardiomyocytes were identified in or near the area of myofilament changes in 86 patients (34%). Morphometrically, fibrosis (odds ratio [OR], 0.96; 95% confidence interval [CI], 0.93 to 0.99) and mitochondrial abnormality (OR, 2.24; 95% CI, 1.23 to 4.08) were independently related with autophagic vacuoles. During the follow-up period of 4.9±3.9 y, 24 patients (10%) died, including 10 (4%) who died of HF, and 67 (27%) were readmitted for HF recurrence. Multivariate analysis identified a family history of DCM (hazard ratio [HR], 2.117; 95% CI, 1.199 to 3.738), hemoglobin level (HR, 0.845; 95% CI, 0.749 to 0.953), myofilament changes (HR, 13.525; 95% CI, 5.340 to 34.255), and autophagic vacuoles (HR, 0.214; 95% CI, 0.114 to 0.400) as independent predictors of death or readmission due to HF recurrence. In conclusion, autophagic vacuoles in cardiomyocytes are associated with a better HF prognosis in patients with DCM, suggesting autophagy may play a role in the prevention of myocardial degeneration.

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  • Ultrastructural features of cardiomyocytes in dilated cardiomyopathy with initially decompensated heart failure as a predictor of prognosis. 査読 国際誌

    Tsunenori Saito, Kuniya Asai, Shigeru Sato, Hitoshi Takano, Kyoichi Mizuno, Wataru Shimizu

    European heart journal   36 ( 12 )   724 - 32   2015年3月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：OXFORD UNIV PRESS  

    AIMS: The aim of the present study was to clarify the significance of myocardial ultrastructural changes in patients with dilated cardiomyopathy (DCM). METHODS AND RESULTS: Endomyocardial biopsy of the left ventricle was performed in 250 consecutive DCM patients (54.9 ± 13.9 years, 79% men), presenting initially as decompensated heart failure (HF). Myofilament changes of cardiomyocytes were evaluated by electron microscopy and compared with clinical and morphometric data. Mortality and HF recurrence were evaluated during the follow-up period. During the follow-up period (4.9 ± 3.9 years), 24 patients (10%) died and 67 (27%) were readmitted because of HF recurrence, including those who had died because of HF. Myofilament changes, classified as either focal derangement of myofilaments (sarcomere damage) or diffuse myofilament lysis (disappearance of most sarcomeres in cardiomyocytes), were identified in 164 patients (66%). Multivariate analysis identified a family history of DCM [hazard ratio (HR) 4.763; 95% confidence interval (CI) 1.012-12.518], atrial fibrillation (HR 6.132; 95% CI 2.188-17.180), haemoglobin level (HR 0.685; 95% CI 0.528-0.889), and diffuse myofilament lysis (HR 4.048; 95% CI 1.427-11.481) as independent predictors of mortality. A family history of DCM (HR 2.268; 95% CI 1.276-4.030), haemoglobin level (HR 0.876; 95% CI 0.785-0.979), focal derangement of myofilaments (HR 7.431; 95% CI 2.916-18.934), and diffuse myofilament lysis (HR 6.480; 95% CI 2.403-17.473) were predictors of readmission due to HF recurrence. CONCLUSIONS: In DCM patients with first-decompensated HF, myofilament changes are strongly associated with mortality and HF recurrence.

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  • Acute myocarditis associated with coxsackievirus B4 mimicking influenza myocarditis: electron microscopy detection of causal virus of myocarditis. 査読 国際誌

    Takeshi Ikeda, Tsunenori Saito, Gen Takagi, Shigeru Sato, Hitoshi Takano, Yusuke Hosokawa, Meiso Hayashi, Kuniya Asai, Masahiro Yasutake, Kyoichi Mizuno

    Circulation   128 ( 25 )   2811 - 2   2013年12月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1161/CIRCULATIONAHA.112.000602

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  • Acute Myocarditis Associated With Coxsackievirus B4 Mimicking Influenza Myocarditis Electron Microscopy Detection of Causal Virus of Myocarditis 査読

    Takeshi Ikeda, Tsunenori Saito, Gen Takagi, Shigeru Sato, Hitoshi Takano, Yusuke Hosokawa, Meiso Hayashi, Kuniya Asai, Masahiro Yasutake, Kyoichi Mizuno

    CIRCULATION   128 ( 25 )   2811 - 2812   2013年12月

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    記述言語：英語   出版者・発行元：LIPPINCOTT WILLIAMS & WILKINS  

    DOI： 10.1161/CIRCULATIONAHA.112.000602

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  • Proof of myocardial autophagy by combining antigen retrieval and the avidin-biotin peroxidase complex method. 査読 国際誌

    Tsunenori Saito, Kuniya Asai, Shigeru Sato, Hitoshi Takano, Akiko Adach, Yoshihiro Sasaki, Shigeki Namimatsu, Kyoichi Mizuno

    International journal of cardiology   168 ( 5 )   4843 - 4   2013年10月

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    記述言語：英語   出版者・発行元：ELSEVIER IRELAND LTD  

    DOI： 10.1016/j.ijcard.2013.07.032

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  • Myocardial alterations and clinical implications associated with recovery of cardiac function in dilated cardiomyopathy with obesity 査読

    Tsunenori Saito, Kuniya Asai, Shigeru Sato, Gen Takagi, Hitoshi Takano, Hiroshi Takahashi, Masahiro Yasutake, Kyoichi Mizuno

    International Journal of Cardiology   168 ( 1 )   144 - 150   2013年9月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Background: Obesity is associated with an increased risk of heart failure (HF) but the relationship between changes in cardiac function and the specific pathological features of dilated cardiomyopathy (DCM) with obesity, remains unknown. Methods: Endomyocardial biopsies from the left ventricle (LV) were obtained from 50 patients with DCM, at the first-onset of decompensated HF. Thirty patients were obese (obese-group: body mass index &gt
    30 kg/m 2) and 20 were non-obese (lean-group). Clinical data were acquired at the admission, after one month and one year. Results: The obese-group had higher systolic blood pressure (142.8 ± 33.9 vs 113.6 ± 18.7 mm Hg
    p &lt
    0.001) and serum troponin-T level (0.049 ± 0.07 vs 0.020 ± 0.03 ng/mL
    p = 0.022) than the lean-group. LV ejection fraction (LVEF) was not significantly different between groups, but after one year the obese-group had an improved LVEF (57.0 ± 11.4 vs 44.3 ± 17.1
    p = 0.003). Light microscopy revealed that the obese-group had larger cardiomyocytes (17.2 ± 1.7 vs 16.4 ± 1.4 μm
    p = 0.033) and less myofilament lysis (37 vs 75%
    p = 0.008) with a higher density of lipid droplets (1.93 ± 0.8 vs 0.94 ± 0.7 /μm2
    p &lt
    0.001). Multivariate regression analysis revealed that independent predictors of LVEF improvement after 12 months were diuretics use, nuclear diameter, and absence of myofilament lysis (p = 0.024, 0.012 and 0.028, respectively). Conclusions: Cardiac function in most patients with DCM with obesity is reversible and myocardial structural changes are trivial even at the ultrastructural level. © 2012 Elsevier Ireland Ltd. All rights reserved.

    DOI： 10.1016/j.ijcard.2012.09.046

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  • Myocardial alterations and clinical implications associated with recovery of cardiac function in dilated cardiomyopathy with obesity. 査読 国際誌

    Tsunenori Saito, Kuniya Asai, Shigeru Sato, Gen Takagi, Hitoshi Takano, Hiroshi Takahashi, Masahiro Yasutake, Kyoichi Mizuno

    International journal of cardiology   168 ( 1 )   144 - 50   2013年9月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：ELSEVIER IRELAND LTD  

    BACKGROUND: Obesity is associated with an increased risk of heart failure (HF) but the relationship between changes in cardiac function and the specific pathological features of dilated cardiomyopathy (DCM) with obesity, remains unknown. METHODS: Endomyocardial biopsies from the left ventricle (LV) were obtained from 50 patients with DCM, at the first-onset of decompensated HF. Thirty patients were obese (obese-group: body mass index >30 kg/m(2)) and 20 were non-obese (lean-group). Clinical data were acquired at the admission, after one month and one year. RESULTS: The obese-group had higher systolic blood pressure (142.8 ± 33.9 vs 113.6 ± 18.7 mm Hg; p<0.001) and serum troponin-T level (0.049 ± 0.07 vs 0.020 ± 0.03 ng/mL; p=0.022) than the lean-group. LV ejection fraction (LVEF) was not significantly different between groups, but after one year the obese-group had an improved LVEF (57.0 ± 11.4 vs 44.3 ± 17.1; p=0.003). Light microscopy revealed that the obese-group had larger cardiomyocytes (17.2 ± 1.7 vs 16.4 ± 1.4 μm; p=0.033) and less myofilament lysis (37 vs 75%; p=0.008) with a higher density of lipid droplets (1.93 ± 0.8 vs 0.94 ± 0.7 /μm(2); p<0.001). Multivariate regression analysis revealed that independent predictors of LVEF improvement after 12 months were diuretics use, nuclear diameter, and absence of myofilament lysis (p=0.024, 0.012 and 0.028, respectively). CONCLUSIONS: Cardiac function in most patients with DCM with obesity is reversible and myocardial structural changes are trivial even at the ultrastructural level.

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  • Histopathological and clinical characteristics of duodenal gastrointestinal stromal tumors as predictors of malignancy. 査読 国際誌

    Tsunenori Saito, Masaki Ueno, Yasunori Ota, Yoshiharu Nakamura, Masaji Hashimoto, Harushi Udagawa, Kyoichi Mizuno, Kenichi Ohashi, Goro Watanabe

    World journal of surgical oncology   11   202 - 202   2013年8月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：BIOMED CENTRAL LTD  

    BACKGROUND: Although gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract, they are very rare. This study evaluated clinical and histopathological characteristics of duodenal GISTs to identify factors useful in predicting prognosis for patients with these tumors. METHODS: A retrospective study was performed on 20 patients who had undergone surgery between 1987 and 2009 for duodenal GISTs. Clinical, histopathological, and immunohistochemical data were evaluated. Survival analyses were conducted using Kaplan-Meier estimates. RESULTS: In 12 patients (60%), duodenal GISTs were diagnosed incidentally. Eight cases (40%) were classified as high risk grade GISTs. Skeinoid fibers (SkF), which are eosinophilic globular hyaline deposits in the extracellular interstitium of the tumor, were found in 12 patients. Skeinoid fibers were not recognized in 8 cases, and these included 3 cases (37.5%) where tumors recurred after surgery and the patient died. Tumors without SkF were larger (81 ± 92 vs. 23 ± 8 mm, P < 0.001) and had a higher mitotic count (224.0 ± 336.6 vs. 0.0 ± 0.0 /50 high-power field, P < 0.001) than those with SkF. Survival time was shorter in patients with tumors lacking SkF (52.9 ± 50.7 vs. 108.9 ± 86.5 months, P = 0.019). CONCLUSIONS: We have identified clinical and histopathological characteristics that were useful in predicting the prognosis of patients with duodenal GISTs. In this study, 60% of the tumors were found incidentally, SkF were not recognized in tumors from 40% of patients, and all cases of post-operative tumor recurrence and death occurred in this subgroup of patients.

    DOI： 10.1186/1477-7819-11-202

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  • Coincidence of multiple endocrine neoplasia type 2A with acromegaly. 査読 国際誌

    Tsunenori Saito, Daishu Miura, Manabu Taguchi, Akira Takeshita, Megumi Miyakawa, Yasuhiro Takeuchi

    The American journal of the medical sciences   340 ( 4 )   329 - 31   2010年10月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：LIPPINCOTT WILLIAMS & WILKINS  

    Medullary thyroid carcinoma (MTC) occurs as a part of multiple endocrine neoplasia (MEN) type 2. Acromegaly, a pituitary adenoma, occurs as a part of MEN1. Rarely, MEN2 and MEN1 coexist in a single patient simultaneously. A 40-year-old man with a history of pituitary adenomectomy for acromegaly had a surgical resection of thyroid carcinoma clinically diagnosed as MTC. His mother, who had MTC and pheochromocytoma, had a germline mutation in the RET gene that could cause the subtype, MEN2A. Identification of gene mutations in RET and MEN1 were examined in the subject. The resected tumor was pathologically diagnosed as MTC. Genomic examinations revealed the RET mutation C634F, which was identical to the mutation of his mother, but no MEN1 gene mutation was found. Although the simultaneous occurrence of both MEN2A and sporadic acromegaly may be accidental, there is evidence to suggest a genetic interaction between MEN2 and acromegaly.

    DOI： 10.1097/MAJ.0b013e3181e73fba

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  • Effects of long-term treatment for obstructive sleep apnea on pulse wave velocity. 査読 国際誌

    Tsunenori Saito, Tsunehiro Saito, Shigeyuki Sugiyama, Kuniya Asai, Masahiro Yasutake, Kyoichi Mizuno

    Hypertension research : official journal of the Japanese Society of Hypertension   33 ( 8 )   844 - 9   2010年8月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：NATURE PUBLISHING GROUP  

    Continuous positive airway pressure (CPAP) treatment improves endothelial function and sympathetic activity in patients with obstructive sleep apnea (OSA). However, the long-term effects of CPAP on pulse wave velocity (PWV), which reflects arterial stiffness that is associated with cardiovascular events, have not been evaluated in OSA patients with or without hypertension (HT). In this study, 212 male OSA patients who had been receiving CPAP treatment for 2 years and were divided into two groups, those with HT (n=114) and those without (n=98), were studied. In both HT and normotensive (NT) patients, PWV decreased significantly over the first 6 months of treatment (P=0.005 and 0.010, respectively), before increasing gradually from 6 to 24 months. Body mass index (BMI), body weight, heart rate (HR), systolic blood pressure (SBP) and diastolic blood pressure (DBP) levels decreased significantly in the HT group over the 2 years of CPAP treatment (P<0.001 for all). In contrast, only HR decreased significantly in the NT group over the 2 years of treatment (P<0.001). Multivariate regression analysis revealed that age (P=0.008), decreases in DBP (P<0.001) and HR (P<0.001) and higher initial levels of serum high-density lipoprotein-cholesterol (P=0.040) were independent factors related to changes in PWV over the 2 years of CPAP treatment in all patients. In conclusion, we found a significant decrease in PWV in both NT and HT patients after 6 months of CPAP treatment. In HT patients, long-term CPAP treatment significantly decreases blood pressure, which may contribute to explain the PWV improvement.

    DOI： 10.1038/hr.2010.77

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  • A patient with pregnancy-related acute abdomen after hemodialysis for over 18 years 査読

    T. Saito, Y. Ubara, T. Suwabe, Y. Higa, S. Nakanishi, J. Hoshino, N. Sawa, H. Katori, F. Takemoto, R. Marui, M. Nakamura, S. Tomikawa, S. Hara, H. Tohbai, K. Takaichi

    CLINICAL NEPHROLOGY   71 ( 3 )   345 - 349   2009年3月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：DUSTRI-VERLAG DR KARL FEISTLE  

    Because pregnancy is rare in women with end-stage renal disease, dialysis patients have not been reported to present with acute abdominal symptoms related to pregnancy including ectopic pregnancy. A 41-year-old woman treated with hemodialysis for over 18 years was brought to the emergency room at our institution because of acute abdominal pain. Ultrasonography detected an abdominal fluid collection, and her anemia had worsened (hematocrit 18%). Emergency laparoscopic exploration disclosed a hemorrhagic corpus luteum of pregnancy, causing ovarian bleeding on the left. Coagulation of bleeding points was carried out. At this time, pregnancy at 7 weeks of gestation was discovered. After the procedures, hemodialysis frequency was increased to 5 times weekly, and an erythropoietin derivative was administered to maintain a hematocrit above 30%. The patient developed no hypertension. At 33 weeks of gestation, cesarean section was performed because of a decrease in amniotic fluid and frequent late deceleration of the fetal heart rate. Alive baby girl weighing 1,422 g was born. The successful pregnancy reflects remarkable progress in dialysis technology. Pregnancy, then, can underlie an acute abdomen in childbearing-age women (14 - 44 years old) undergoing long-term dialysis.

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  • Rapid exacerbation in an elderly case of adult-onset X-linked adrenoleukodystrophy with cerebral corticospinal tract involvement. 査読 国際誌

    Tsunenori Saito, Tomoyuki Mizuno, Tomoji Watanabe, Masayoshi Ida, Hirofumi Nakase

    Archives of neurology   65 ( 3 )   416 - 7   2008年3月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：AMER MEDICAL ASSOC  

    DOI： 10.1001/archneur.65.3.416

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  • Histopathological evaluation of left atrial appendage thrombogenesis removed during surgery for atrial fibrillation. 査読 国際誌

    Tsunenori Saito, Koichi Tamura, Daisuke Uchida, Tomonari Saito, Takashi Nitta, Yuichi Sugisaki

    American heart journal   153 ( 4 )   704 - 11   2007年4月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：MOSBY-ELSEVIER  

    BACKGROUND: In this study, we histopathologically assessed left atrial appendages (LAAs) resected during surgical treatment for atrial fibrillation (AF) to elucidate the mechanism of intra-LAA thrombus formation in valvular AF. METHODS: The clinicopathological study of resected LAA was made on 56 valvular AF cases: 28 with mitral regurgitation (MR), 3 with mitral stenosis, and 25 with mitral stenosis and MR. Pathological findings of thrombi in LAA were compared with clinical features, including history of valvular diseases and embolism, and findings of echocardiography. Results were analyzed using chi2 test, Fisher exact method, or Welch t test. RESULTS: Two types of mural thrombi were found in LAA: membranous (M)-thrombi and polypoid-shape (P)-thrombi. M-thrombi were found on LAA endocardium in 48 (86%) patients. All of the P-thrombi were observed on preexisting M-thrombi. More patients showed thrombi in the LAA orifice than in the tip (P < .001), especially in cases of MR (21 patients; P < .01). By echocardiography, MR flow was classified into 3 directions: toward the roof, anteroseptal, or posterolateral wall of the left atrium. Patients with MR jet flow against the posterolateral wall near the LAA entrance had a higher risk of LAA thrombi (P = .007). CONCLUSIONS: Instability of M-thrombi, including surface rupture before complete organization, relates to P-thrombi formation that results in high incidence of embolism in AF patients.

    DOI： 10.1016/j.ahj.2007.01.036

    Web of Science

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  • Histopathological features of the resected left atrial appendage as predictors of recurrence after surgery for atrial fibrillation in valvular heart disease. 査読

    Tsunenori Saito, Koichi Tamura, Daisuke Uchida, Tomonari Saito, Mayuko Togashi, Takashi Nitta, Yuichi Sugisaki

    Circulation journal : official journal of the Japanese Circulation Society   71 ( 1 )   70 - 8   2007年1月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：JAPANESE CIRCULATION SOCIETY  

    BACKGROUND: A histopathological assessment of left atrial appendages (LAA) resected during surgical treatment for atrial fibrillation (AF) was made, with the aim of improving the prediction of postoperative AF recurrence. METHODS AND RESULTS: This clinicopathological study involved 57 surgical cases of valvular AF and 34 age- and sex-matched control autopsy cases with a history of sinus rhythm. LAA from the cases with valvular AF showed greater hypertrophy of cardiomyocytes (p<0.0001), greater nuclear enlargement (p<0.0001), more bizarre nuclei (BN; p<0.0001), and more intercellular fibrosis (ICF; p<0.001). Partial disarray of cardiomyocytes and fatty infiltration were recognized in both the AF and control groups. Thirty-seven cases had maintained sinus rhythm after surgery from 7 months to 10 years. AF recurred within a month of surgery in 17 and after a month in 3; there was no significant difference in histopathological features between them. These 20 cases had more cellular hypertrophy (p<0.025), nuclear enlargement (p<0.025), BN (p<0.01), and ICF (p<0.025) than those who maintained sinus rhythm after surgery. CONCLUSIONS: The histopathological findings for LAA reflected the underlying valvular diseases; however, the most reliable predictors of postoperative AF recurrence were hypertrophy of cardiomyocytes, bizarre shaped nuclei, and extensive ICF.

    DOI： 10.1253/circj.71.70

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書籍等出版物

  • フレームワークで考える内科診断

    Mansoor, André M, 田中, 竜馬

    メディカル・サイエンス・インターナショナル  2021年7月  （ ISBN:9784815730215 ）

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    総ページ数：xvi, 657p   記述言語：日本語  

    CiNii Books

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  • 診断モダリティとしての心筋病理

    心筋生検研究会（ 担当： 分担執筆 範囲: 電子顕微鏡のエビデンス）

    南江堂  2017年3月 

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  • 電子顕微鏡アトラス 心内膜下心筋生検

    佐藤 茂, 齋藤 恒徳（ 担当： 共著）

    日新EM株式会社  2015年5月 

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MISC

  • 脳梗塞を契機に診断されたCOVID-19ワクチン関連心筋炎

    渡辺 允, 齋藤 恒徳, 小谷 英太郎

    ICUとCCU   46 ( 別冊 )   S53 - S56   2022年12月

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    記述言語：日本語   出版者・発行元：医学図書出版(株)  

    症例は38歳女性。特記すべき既往なし。突然の左上肢巧緻運動障害と心窩部痛,呼吸困難を認めた。4日後左下肢知覚障害および不全麻痺が出現し脳神経外科受診。頭部MRIで右大脳半球,左後頭葉に散在性脳梗塞を認め,心原性脳塞栓が疑われ循環器内科紹介となった。入院時の心電図は104bpmと洞頻脈,aVLとV5～V6誘導に小さなQ波,IIIとaVF誘導に陰性T波を認めたが非特異的所見であった。血液生化学検査で心筋逸脱酵素(CK/CK-MB)は正常範囲内だが,高感度トロポニンT0.682ng/mL,NT-proBNP395pg/mLと上昇し何らかの心筋障害が示唆された。経胸壁心臓超音波で左室駆出率は72%と保たれていたが全周性に心嚢液貯留を認め,急性心筋炎を強く疑った。受診3週間前にSARS-CoV-2 mRNAワクチン(COVID-19ワクチンモデルナ筋注)の2回目の接種が完了し,時系列からCOVID-19ワクチン関連心筋炎が考えられた。画像および病理所見より考察する。(著者抄録)

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  • 拡張型心筋症の遺伝子変異と電子顕微鏡 招待 査読

    齋藤 恒徳

    国際抗老化再生医療学会雑誌   4 ( 1 )   1 - 11   2022年10月

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    担当区分：筆頭著者   記述言語：日本語   掲載種別：記事・総説・解説・論説等（学術雑誌）  

    添付ファイル： Op.27 拡張型心筋症の遺伝子変異と電子顕微鏡.pdf

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  • HLA-DR4陽性であった巨細胞性動脈炎の1例

    岡部 杏慈, 東 直行, 齋藤 恒徳, 草間 芳樹, 佐伯 秀久

    臨床皮膚科   74 ( 2 )   127 - 131   2020年2月

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    記述言語：日本語   出版者・発行元：(株)医学書院  

    ＜文献概要＞75歳,男性.初診の3ヵ月前から両肩・股関節周囲の疼痛があり,歩行困難をきたしリウマチ性多発筋痛症を疑われ当院内科で精査中であった.左側頭動脈の怒張と索状硬結を認めたため当科にて生検を施行した.筋性血管のほぼ全層に多核巨細胞を含む炎症細胞浸潤がみられ,内腔に血栓を認めたため巨細胞性動脈炎の合併と診断した.血清対応型タイピングではHLA-DR4が陽性であった.全身症状として発熱,体重減少があり,貧血がみられた.本邦では稀な巨細胞性動脈炎であるが欧米では頻度が高くHLA-DR4陽性の地域差が関連している.HLA-DR4の保有の有無,入院時のHb値,随伴する全身症状は巨細胞性動脈炎の眼虚血性合併症の予測因子や予後に関連すると報告されており,ステロイドへの治療反応性も関連する可能性があるため精査は重要である.

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    その他リンク： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2020&ichushi_jid=J01559&link_issn=&doc_id=20200302040008&doc_link_id=10.11477%2Fmf.1412205946&url=https%3A%2F%2Fdoi.org%2F10.11477%2Fmf.1412205946&type=%88%E3%8F%91.jp_%83I%81%5B%83%8B%83A%83N%83Z%83X&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

  • 【U40世代が描く心不全診療の現状と未来-基礎研究を識り,臨床を素心深考する】心筋症 心筋症のreversibilityを病理所見から予測する

    齋藤 恒徳

    循環器ジャーナル   68 ( 1 )   94 - 98   2020年1月

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    記述言語：日本語   出版者・発行元：(株)医学書院  

    ＜文献概要＞Point ・心筋症の病理学的検索法のうち,電子顕微鏡では,心筋細胞の細胞内小器官や筋原線維の超微形態変化を詳細に観察できる.・筋原線維や核の変性は不良な予後を,オートファジー空胞の存在は良好な予後を予測させる.・超微構造の解析が心筋症の病態解明に寄与することが期待される.

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  • Comparison Between Ultrastructural Features and Causative Genes of Dilated Cardiomyopathy Detected by Whole Exome Sequencing

    Tsunenori Saito, Kuniya Asai, Naoko Saito-Sato, Kosuke Mozawa, Eiichiro Oka, Shigeru Sato, Kyoichi Mizuno, Roberta A. Gottlieb, Wataru Shimizu

    CIRCULATION   140   2019年11月

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    記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）   出版者・発行元：LIPPINCOTT WILLIAMS & WILKINS  

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  • Dilated Cardiomyopathy Includes Arrhythmogenic Cardiomyopathy as a Type With Severe Myocardial Degeneration

    Kosuke Mozawa, Tsunenori Saito, Eiichiro Oka, Naoko Saito-Sato, Eitaro Kodani, Yu-ki Iwasaki, Kuniya Asai, Wataru Shimizu

    CIRCULATION   140   2019年11月

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    記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）   出版者・発行元：LIPPINCOTT WILLIAMS & WILKINS  

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  • 拡張型心筋症の電子顕微鏡所見の臨床的意義とオートファジー発現に関与する因子の探索

    齋藤 恒徳

    日本医科大学医学会雑誌   14 ( 4 )   200 - 200   2018年10月

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    記述言語：日本語   出版者・発行元：日本医科大学医学会  

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  • 急性心筋梗塞発症後早期に消化管合併症のため抗血小板薬を中止し,ステント血栓症を発症し救命しえなかった1例

    中野博之, 齋藤恒徳, 森澤太一郎, 小谷英太郎, 清水渉

    日本内科学会関東支部関東地方会   642nd   24 - 24   2018年6月

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    記述言語：日本語   出版者・発行元：日本内科学会-関東地方会  

    J-GLOBAL

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  • 急性心筋梗塞発症後早期に消化管合併症のため抗血小板薬を中止し、ステント血栓症を発症し救命しえなかった1例

    中野 博之, 齋藤 恒徳, 森澤 太一郎, 小谷 英太郎, 清水 渉

    日本内科学会関東地方会   642回   24 - 24   2018年6月

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    記述言語：日本語   出版者・発行元：日本内科学会-関東地方会  

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  • 右胃大網動脈を使用した冠動脈バイパス術後の進行胃癌に対して,経皮的冠動脈形成術による血行再建後に幽門側胃切除を行った症例

    中野博之, 高木信介, 齋藤恒徳, 森澤太一郎, 小谷英太郎, 清水渉

    日本内科学会関東支部関東地方会   641st   25 - 25   2018年5月

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    記述言語：日本語   出版者・発行元：日本内科学会-関東地方会  

    J-GLOBAL

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  • 自覚症状がなく側頭動脈生検で判明した巨細胞性動脈炎を合併したリウマチ性多発筋痛症

    岡部 杏慈, 東 直行, 齋藤 恒徳, 草間 芳樹, 佐伯 秀久

    日本皮膚科学会雑誌   128 ( 6 )   1353 - 1353   2018年5月

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    記述言語：日本語   出版者・発行元：(公社)日本皮膚科学会  

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  • 右胃大網動脈を使用した冠動脈バイパス術後の進行胃癌に対して、経皮的冠動脈形成術による血行再建後に幽門側胃切除を行った症例

    中野 博之, 高木 信介, 齋藤 恒徳, 森澤 太一郎, 小谷 英太郎, 清水 渉

    日本内科学会関東地方会   641回   25 - 25   2018年5月

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    記述言語：日本語   出版者・発行元：日本内科学会-関東地方会  

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  • 次世代シーケンサーを用いた標的遺伝子解析および超微細構造解析を応用した拡張型心筋症の原因遺伝子の探索

    齋藤恒徳, 浅井邦也, 佐藤奈穂子, 茂澤幸右, 岡英一郎, 佐藤茂, 小谷英太郎, 清水渉

    日本人類遺伝学会大会プログラム・抄録集   63rd   2018年

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  • 平成29年度 同窓会医学研究助成金受賞記念講演（2）

    齋藤 恒徳

    日本医科大学医学会雑誌   14 ( 4 )   200 - 200   2018年

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    記述言語：日本語   出版者・発行元：日本医科大学医学会  

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  • 虚血性心疾患と冠微小循環障害 微小血管狭心症において、炎症は発症、長期予後に関与する

    中込 明裕, 森澤 太一郎, 小橋 啓一, 小杉 宗範, 斎藤 恒徳, 小谷 英太郎, 草間 芳樹, 清水 渉

    日本心臓病学会学術集会抄録   65回   S5 - 5   2017年9月

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    記述言語：日本語   出版者・発行元：(一社)日本心臓病学会  

    J-GLOBAL

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  • 心内膜心筋生検による病理診断の役割と重要性 拡張型心筋症の心内膜心筋生体標本における電子顕微鏡所見の臨床的有用性

    齋藤 恒徳

    日本病理学会会誌   106 ( 1 )   207 - 207   2017年3月

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    記述言語：日本語   出版者・発行元：(一社)日本病理学会  

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  • QT延長症候群の原因として、ACTH単独欠損症が疑われた1例

    山下 貴正, 中込 明裕, 中野 博之, 齋藤 恒徳, 小橋 啓一, 森澤 太一郎, 川口 直美, 小谷 英太郎, 井川 修, 草間 芳樹

    日本内科学会関東地方会   630回   66 - 66   2017年2月

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    記述言語：日本語   出版者・発行元：日本内科学会-関東地方会  

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  • 心機能の回復を予測する拡張型心筋症患者における心臓MRIと心筋超微細構造との比較

    SAITO Tsunenori, ASAI Kuniya, SATO Shigeru, SHIMIZU Wataru

    日本心不全学会学術集会プログラム・抄録集   21st   2017年

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  • 冠攣縮性狭心症における喫煙に関する検討

    小杉 宗範, 中込 明裕, 齋藤 恒徳, 森澤 太一郎, 小橋 啓一, 小谷 英太郎, 草間 芳樹, 清水 渉

    日本心臓病学会学術集会抄録   64回   O - 201   2016年9月

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    記述言語：日本語   出版者・発行元：(一社)日本心臓病学会  

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  • How to心筋生検 電子顕微鏡を活用する

    齋藤 恒徳, 清水 渉

    日本心臓病学会学術集会抄録   64回   JS6 - 6   2016年9月

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    記述言語：日本語   出版者・発行元：(一社)日本心臓病学会  

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  • 拡張型心筋症の心筋細胞に認められるオートファジー空胞

    齋藤 恒徳, 浅井 邦也, 清水 渉

    日本医科大学医学会雑誌   12 ( 3 )   76 - 77   2016年6月

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    記述言語：日本語   出版者・発行元：日本医科大学医学会  

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  • P-ANCA陽性糸球体腎炎を合併した感染性心内膜炎の一例

    齋藤恒徳, 小谷英太郎, 野崎文華, 中野博之, 合田浩紀, 田中貴久, 小橋啓一, 森澤太一郎, 村田広茂, 小杉宗範, 中込明裕, 井川修, 草間芳樹, 新博次, 清水渉

    日本循環器学会関東甲信越地方会(Web)   239th   2016年

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  • 早期拡張型心筋症の心筋細胞の超音波像とオートファジーの予後的有用性

    SAITO Tsunenori, ASAI Kuniya, INUI Keisuke, SATO Shigeru, TAKANO Hitoshi, MIZUNO Kyoichi, SHIMIZU Wataru

    Circulation Journal   80 ( Supplement 1(CD-ROM) )   2016年

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  • 左心室心筋の自食作用は初期拡張型心筋症の心機能回復を予測するものである

    SAITO Tsunenori, ASAI Kuniya, SATO Shigeru, TAKANO Hitoshi, MIZUNO Kyoichi, SHIMIZU Wataru

    Circulation Journal   79 ( Supplement 1(CD-ROM) )   2015年

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  • 咳嗽を契機に診断された呼吸周期依存性心房頻拍の一例

    村田広茂, 井川修, 小谷英太郎, 小杉宗範, 合田浩紀, 田中貴久, 齋藤恒徳, 野崎文華, 小橋啓一, 森澤太一郎, 松崎弦, 岡崎怜子, 遠藤育子, 川口直美, 中込明裕, 草間芳樹, 新博次, 宮内靖史, 清水渉

    日本循環器学会関東甲信越地方会(Web)   238th   2015年

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  • 単冠動脈症に重症冠動脈病変を合併した虚血性心筋症の一例

    合田浩紀, 小谷英太郎, 松崎弦, 林耕次, 中野博之, 齋藤恒徳, 野崎文華, 原千鶴子, 小橋啓一, 森澤太一郎, 小杉宗範, 村田広茂, 中込明裕, 井川修, 草間芳樹, 新博次, 清水渉

    日本循環器学会関東甲信越地方会(Web)   236th   2015年

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  • 特発性心室頻拍との鑑別に造影MRIおよび3D-CTが有用であった右室心尖部瘢痕起源心室頻拍の一例

    村田広茂, 井川修, 小谷英太郎, 合田浩紀, 野間さつき, 齋藤恒徳, 野崎文華, 原千鶴子, 小橋啓一, 森澤太一郎, 小杉宗範, 松崎弦, 岡崎怜子, 中込明裕, 草間芳樹, 新博次, 宮内靖史, 清水渉

    日本循環器学会関東甲信越地方会(Web)   235th   2015年

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  • MOLLI法を用いた心臓MRIでのextracellular volume(ECV)測定と心筋生検組織における線維化の比較

    乾 恵輔, 城 正樹, 斎藤 恒徳, 吉永 綾, 久保田 芳明, 加藤 浩司, 高野 仁司, 天野 康雄, 浅井 邦也, 清水 渉

    日本心臓病学会学術集会抄録   62回   O - 262   2014年9月

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    記述言語：日本語   出版者・発行元：(一社)日本心臓病学会  

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  • In vivo comparison between myocardial fibrosis and myocardial extracellular volume (ECV) measurement by cardiovascular magnetic resonance (CMR)

    K. Inui, M. Tachi, T. Saito, Y. Kubota, K. Murai, K. Kato, H. Takano, Y. Amano, K. Asai, W. Shimizu

    EUROPEAN HEART JOURNAL   35   176 - 177   2014年9月

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    記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）   出版者・発行元：OXFORD UNIV PRESS  

    Web of Science

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  • 電子顕微鏡を用いた早期の拡張型心筋症におけるオートファジーの検出と左室収縮能の改善

    齋藤 恒徳, 浅井 邦也, 佐藤 茂, 高野 仁司, 水野 杏一, 清水 渉

    日本心臓病学会学術集会抄録   62回   O - 216   2014年9月

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    記述言語：日本語   出版者・発行元：(一社)日本心臓病学会  

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  • 急速に拡大した炎症性総腸骨動脈瘤に対し準緊急的EVARを施行したが,血栓閉塞により再治療を要した一例

    野間さつき, 小谷英太郎, 合田浩紀, 中野博之, 齋藤恒徳, 野崎文華, 原千鶴子, 小橋啓一, 森澤太一郎, 小杉宗範, 村田広茂, 中込明裕, 井川修, 草間芳樹, 新博次, 吉尾敬秀, 丸山雄二, 井村肇, 清水渉

    日本循環器学会関東甲信越地方会(Web)   234th   2014年

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  • 心臓MRI所見を示す前の早期拡張型心筋症における超微細構造特徴の予後的有用性

    SAITO Tsunenori, ASAI Kuniya, AMANO Yasuo, SATO Shigeru, TAKANO Hitoshi, MIZUNO Kyoichi, SHIMIZU Wataru

    Circulation Journal   78 ( Supplement 1(CD-ROM) )   2014年

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  • Prognostic Utility of Myocardial Autophagy and Ultrastructural Findings in Early Dilated Cardiomyopathy: Comparison With Cardiac Magnetic Resonance

    Tsunenori Saito, Kuniya Asai, Shigeru Sato, Yasuo Amano, Hitoshi Takano, Kyoichi Mizuno, Wataru Shimizu

    CIRCULATION   128 ( 22 )   2013年11月

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    記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）   出版者・発行元：LIPPINCOTT WILLIAMS & WILKINS  

    Web of Science

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  • Ultrastructural findings of cardiomyocytes in early phase of dilated cardiomyopathy as a predictor of the prognosis

    T. Saito, K. Asai, S. Sato, E. Yamamoto, H. Takano, M. Yasutake, K. Mizuno

    EUROPEAN JOURNAL OF HEART FAILURE   12   S317 - S318   2013年5月

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    記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）   出版者・発行元：WILEY-BLACKWELL  

    Web of Science

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  • 拡張型心筋症の早期相における心筋細胞の微細構造所見

    SAITO Tsunenori, ASAI Kuniya, SATO Shigeru, TAKANO Hitoshi, TAKAGI Gen, YASUTAKE Masahiro, MIZUNO Kyoichi

    Circulation Journal   77 ( Supplement 1(CD-ROM) )   2013年

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  • Clinical significance of detecting abnormal fatty acid metabolism with iodine-123 15-(p-iodophenyl)-3-(R, S) methylpentadecanoic acid imaging in patients with dilated cardiomyopathy

    A. Yoshida, H. Takano, T. Saito, S. Nakamura, S. Tara, G. Takagi, K. Asai, S. Kumita, Y. Amano, K. Mizuno

    EUROPEAN HEART JOURNAL   33   246 - 246   2012年8月

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    記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）   出版者・発行元：OXFORD UNIV PRESS  

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  • Autophagic vacuolization of cardiomyocyte predicts good prognosis in early phase of dilated cardiomyopathy

    T. Saito, K. Asai, S. Sato, H. Takano, G. Takagi, M. Yasutake, K. Mizuno

    EUROPEAN HEART JOURNAL   33   646 - 646   2012年8月

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    記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）   出版者・発行元：OXFORD UNIV PRESS  

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  • 左前下行枝の近位病変に対するPCI後の臨床転帰にステント留置法は影響を及ぼすか?

    KO Toshinori, TAKANO Hitoshi, IZUMI Yuki, YUMAMOTO Yoshiya, WAKAKURI Hiroaki, KUBOTA Yoshiaki, SAITO Tsunenori, YOSHIDA Asuka, NAKAMURA Shunichi, KAMIYA Masataka, TARA Shuhei, MURAI Koji, TOKITA Yukichi, INAMI Shigenobu, TAKAGI Gen, ASAI Kuniya, YASUTAKE Masahiro, MIZUNO Kyoichi

    日本心血管インターベンション治療学会誌   4 ( Supplement 2 )   2012年

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  • 心筋細胞の自己貪食空胞化は拡張型心筋症の早期における予後良好を予測する

    SAITO Tsunenori, ASAI Kuniya, SATO Shigeru, TAKANO Hitoshi, TAKAHASHI Hiroshi, TAKAGI Gen, YASUTAKE Masahiro, MIZUNO Kyoichi

    Circulation Journal   76 ( Supplement 1(CD-ROM) )   2012年

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  • Autophagic myocardial degeneration and improvement of ventricular function in obesity cardiomyopathy as an appropriate model of load-induced heart failure

    T. Saito, K. Asai, H. Takano, S. Sato, Y. Fukuda, K. Mizuno

    EUROPEAN HEART JOURNAL   32   613 - 613   2011年8月

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    記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）   出版者・発行元：OXFORD UNIV PRESS  

    Web of Science

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  • AUTOPHAGIC MYOCARDIAL DEGENERATION AND CLINICAL IMPLICATION IN OBESITY CARDIOMYOPATHY AS AN APPROPRIATE MODEL OF LOAD-INDUCED HEART FAILURE

    Tsunenori Saito, Kuniya Asai, Hitoshi Takano, Hiroshi Takahashi, Gen Takagi, Shigeru Sato, Yuh Fukuda, Kyoichi Mizuno

    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY   57 ( 14 )   E283 - E283   2011年4月

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    記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）   出版者・発行元：ELSEVIER SCIENCE INC  

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  • 心筋生検による肥満心筋症の臨床病理学的検討

    斎藤 恒徳, 浅井 邦也, 高野 仁司, 佐藤 茂, 水野 杏一, 福田 悠

    日本病理学会会誌   100 ( 1 )   341 - 341   2011年3月

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    記述言語：日本語   出版者・発行元：(一社)日本病理学会  

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  • 負荷誘発心疾患の適切なモデルとしての肥満心筋症における心筋のオートファジー変性と臨床的意義

    SAITO Tsunenori, ASAI Kuniya, TAKANO Hitoshi, TAKAHASHI Hiroshi, TAKAGI Gen, SATO Shigeru, FUKUDA Yuh, MIZUNO Kyoichi

    Circulation Journal   75 ( Supplement 1(CD-ROM) )   2011年

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  • Ultrastructural evaluation of cardiac myocyte alterations with obesity cardiomyopathy

    T. Saito, K. Asai, H. Takahashi, E. Yamamoto, H. Takano, S. Sato, Y. Fukuda, K. Mizuno

    EUROPEAN HEART JOURNAL   31   632 - 632   2010年9月

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    記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）   出版者・発行元：OXFORD UNIV PRESS  

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  • 閉塞性睡眠時無呼吸症候群に対する持続陽圧換気療法の脈波伝播速度における長期的影響

    斎藤 恒徳, 斎藤 恒博, 杉山 重幸, 浅井 邦也, 安武 正弘, 水野 杏一

    日本心臓病学会誌   5 ( Suppl.I )   481 - 481   2010年8月

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    記述言語：日本語   出版者・発行元：(一社)日本心臓病学会  

    J-GLOBAL

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  • ANCA関連血管炎に合併した胸腹部大動脈瘤の1例

    林 裕美, 高橋 啓, 高野 仁司, 宮元 亮子, 齋藤 恒徳, 福井 めぐみ, 水野 杏一

    日本内科学会関東地方会   569回   54 - 54   2010年2月

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    記述言語：日本語   出版者・発行元：日本内科学会-関東地方会  

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  • 心房ペーシングリードが惹起した重度三尖弁逆流症の1例

    齋藤 恒徳, 浅井 邦也, 加藤 浩司, 高木 元, 稲見 茂信, 高橋 啓, 山本 英世, 高野 仁司, 新田 隆, 水野 杏一

    日本内科学会関東地方会   569回   56 - 56   2010年2月

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    記述言語：日本語   出版者・発行元：日本内科学会-関東地方会  

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  • 冠動脈血行再建を受ける患者におけるSYNTAXスコアの予測的価値

    NAKAMURA Shunichi, TAKANO Hitoshi, INUI Keisuke, SAITO Tsunenori, NAKANO Hiroyuki, NOZAKI Fumika, KOMIYAMA Hidenori, TARA Shuhei, YAMAMOTO Eisei, KATOH Koji, INAMI Shigenobu, TAKAGI Gen, AOKI Satoshi, ASAI Kuniya, YASUTAKE Masahiro, MIZUNO Kyoichi

    Circulation Journal   74 ( Supplement 1 )   2010年

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  • 経皮的腎動脈形成術の潜在的腎保護作用:血圧低下依存性現象

    YAMAMOTO Eisei, TAKANO Hitoshi, SAITO Tsunenori, KOMIYAMA Hidenori, NAKAMURA Shunichi, TARA Shuhei, KATO Koji, INAMI Shigenobu, TAKAGI Gen, ASAI Kuniya, YASUTAKE Masahiro, MIZUNO Kyoichi

    日本心血管インターベンション治療学会抄録集   19th   2010年

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  • LDH高値にて早期診断に至った無症候性回結腸動脈閉塞症の一例

    田中貴久, 高橋啓, 宮元亮子, 斎藤恒徳, 浅井邦也, 水野杏一

    日本循環器学会関東甲信越地方会(Web)   217th   2010年

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  • 造影剤誘発ネフロパシーの機序の解明及び長期臨床転帰に対するその予防の有益性の証明

    YAMAMOTO Eisei, TAKANO Hitoshi, SAITO Tsunenori, KOMIYAMA Hidenori, NAKAMURA Shunichi, TARA Shuhei, KATO Kouji, INAMI Shigenobu, TAKAGI Gen, ASAI Kuniya, YASUTAKE Masahiro, MIZUNO Kyoichi

    日本心血管インターベンション治療学会抄録集   19th   2010年

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  • Effect of Long-Term Treatment With Continuous Positive Airway Pressure on Pulse Wave Velocity, Hypertension and Obesity in Obstructive Sleep Apnea With Metabolic Syndrome

    Tsunenori Saito, Tsunehiro Saito, Shigeyuki Sugiyama, Kyoichi Mizuno

    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY   53 ( 10 )   A430 - A430   2009年3月

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    記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）   出版者・発行元：ELSEVIER SCIENCE INC  

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  • 慢性腎臓病患者における冠動脈大動脈バイパス移植術後の術後ネフローゼ

    NAKANO Hiroyuki, YAMAMOTO Eisei, TAKANO Hitoshi, INUI Keisuke, SAITO Tsunenori, TARA Shuhei, KATO Koji, INAMI Shigenobu, TAKANO Masamichi, TAKAGI Gen, ASAI Kuniya, YASUTAKE Masahiro, MIZUNO Kyoichi, MARUYAMA Yuji, OCHI Masami

    第18回日本心血管インターベンション治療学会学術集会抄録集,2009   2009年

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  • 十二指腸GIST 12例の臨床病理学的検討

    斎藤 恒徳, 上野 正紀, 高橋 剛, 松田 正道, 橋本 雅司, 宇田川 晴司, 澤田 壽仁, 渡邊 五朗, 大田 泰徳

    日本消化器病学会雑誌   105 ( 臨増大会 )   A781 - A781   2008年9月

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    記述言語：日本語   出版者・発行元：(一財)日本消化器病学会  

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  • 閉塞性睡眠時無呼吸症候群に対する持続陽圧換気療法の脈波伝播速度における長期的影響

    斎藤 恒徳, 斎藤 恒博, 杉山 重幸, 山口 徹, 水野 杏一

    脈管学   48 ( Suppl. )   S177 - S177   2008年9月

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    記述言語：日本語   出版者・発行元：(一社)日本脈管学会  

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  • Improvement in pulse wave velocity by 2-year-treatment of continuous positive airway pressure for patients with obstructive sleep apnea complicated by obesity and hypertension

    Tsunenori Saito, Tsunehiro Saito, Shigeyuki Sugiyama, Kyoichi Mizuno

    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY   51 ( 10 )   A300 - A300   2008年3月

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    記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）   出版者・発行元：ELSEVIER SCIENCE INC  

    Web of Science

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  • 先端巨大症を合併した多発性内分泌腺腫症2A型の1例

    斎藤 恒徳, 田口 学, 竹下 章, 宮川 めぐみ, 三浦 大周, 竹内 靖博

    日本内分泌学会雑誌   83 ( 1 )   101 - 101   2007年4月

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    記述言語：日本語   出版者・発行元：(一社)日本内分泌学会  

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  • 心房細動根治術時に切除された左心耳の病理所見に対する臨床病理学的検討

    斎藤 恒徳, 内田 大介, 斉藤 智成, 田村 浩一, 福田 悠, 杉崎 祐一

    日本病理学会会誌   92 ( 1 )   325 - 325   2003年4月

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    記述言語：日本語   出版者・発行元：(一社)日本病理学会  

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講演・口頭発表等

  • Presenilin-2 regulates mitophagy via promoting SirT1-PGC1α-PINK1 pathway and intracellular translocation of Parkin to mitochondria.

    Saito T, Gottlieb RA, Kodani E

    第87回日本循環器学会学術集会  2023年3月 

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    開催年月日： 2023年3月

    記述言語：英語   会議種別：シンポジウム・ワークショップ パネル（公募）  

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  • Presenilin-2 regulates mitophagy via promoting intracellular translocation of Parkin to mitochondria.

    Saito T, Gottlieb RA, Kodani E

    American Heart Association Scientific Sessions.  2022年11月 

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    開催年月日： 2022年11月

    記述言語：英語   会議種別：ポスター発表  

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  • Genome and Pathology of Dilated Cardiomyopathy. 招待

    Tsunenori Saito

    第26回日本心不全学会学術集会.  2022年10月 

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    開催年月日： 2022年10月

    記述言語：日本語   会議種別：シンポジウム・ワークショップ パネル（指名）  

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  • 日本心臓病学会・心筋生検研究会ジョイントシンポジウム How to 心筋生検; 電子顕微鏡を活用する. 招待

    齋藤 恒徳

    第64回日本心臓病学会学術集会  2016年9月 

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    記述言語：日本語   会議種別：シンポジウム・ワークショップ パネル（指名）  

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  • ランチョンセミナー 心筋生検の役立て方と電子顕微鏡の活用. 招待

    齋藤 恒徳

    第27回日本小児心筋疾患学会学術集会  2018年10月 

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    記述言語：日本語   会議種別：公開講演，セミナー，チュートリアル，講習，講義等  

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  • Ultrastructural assist for searching causative genes of dilated cardiomyopathy using next generation sequencer. 国際会議

    齋藤 恒徳

    日本人類遺伝学会第63回大会  2018年10月 

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    記述言語：英語   会議種別：口頭発表（一般）  

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  • Comparison between ultrastructural features and causative genes of dilated cardiomyopathy detected by whole exome sequencing. 国際会議

    齋藤 恒徳

    American Heart Association Scientific Sessions 2019  2019年11月 

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    記述言語：英語   会議種別：口頭発表（一般）  

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  • Presenilin 1 and Presenilin 2 contribute to mitophagy including alternative pathway.

    Saito T, Gottlieb RA

    American Heart Association  2020年11月 

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    記述言語：英語   会議種別：口頭発表（一般）  

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  • Clinical utility of myocardial autophagy in patients with dilated cardiomyopathy to predict prognosis and recovery of cardiac function; Plenary Session. 国際会議

    齋藤 恒徳

    第81回日本循環器学会学術集会  2017年3月 

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    記述言語：英語   会議種別：シンポジウム・ワークショップ パネル（公募）  

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  • ワークショップ7 心内膜心筋生検による病理診断の役割と重要性; 拡張型心筋症の心内膜心筋生検標本における電子顕微鏡所見の臨床的有用性. 招待

    齋藤 恒徳

    第106回日本病理学会総会  2017年4月 

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    記述言語：日本語   会議種別：シンポジウム・ワークショップ パネル（指名）  

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  • Comparison between cardiac magnetic resonance and myocardial ultrastructural features in patients with dilated cardiomyopathy to predict recovery of cardiac function.

    齋藤 恒徳

    第21回日本心不全学会学術集会  2017年10月 

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    記述言語：英語   会議種別：口頭発表（一般）  

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  • Eosinophilic myocarditis associated with anti-mitochondrial M2 antibodies: a new evidence of the onset of myocarditis. 国際会議

    齋藤 恒徳

    The American College of Physicians Internal Medicine 2018  2018年4月 

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    記述言語：英語   会議種別：ポスター発表  

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  • Autophagic changes in cardiomyocyte predict good prognosis for dilated cardiomyopathy. 招待 国際会議

    齋藤 恒徳

    American Heart Association Scientific Sessions 2012  2012年11月 

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    記述言語：英語   会議種別：シンポジウム・ワークショップ パネル（指名）  

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  • Ultrastructural findings of cardiomyocytes in early phase of dilated cardiomyopathy. 招待 国際会議

    齋藤 恒徳

    第77回日本循環器学会学術集会  2013年3月 

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    記述言語：英語   会議種別：シンポジウム・ワークショップ パネル（指名）  

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  • Prognostic utility of ultrastructural features and autophagy in cardiomyocytes for early dilated cardiomyopathy. 国際会議

    齋藤 恒徳

    第80回日本循環器学会学術集会  2016年3月 

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    記述言語：日本語   会議種別：シンポジウム・ワークショップ パネル（公募）  

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  • Myocarditis and cardiovascular pathology; Joint symposium of the Japanese Circulation Society and Cardiac Biopsy Conference. 招待 国際会議

    齋藤 恒徳

    第80回日本循環器学会学術集会  2016年3月 

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    記述言語：日本語   会議種別：シンポジウム・ワークショップ パネル（指名）  

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▼全件表示

受賞

  • 2019 BCVS Abstract Travel Grant

    2019年11月   American Heart Association  

    齋藤 恒徳

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  • The Best 50 Abstracts Award from the American College of Physicians Internal Medicine 2018

    2018年4月   American College of Physicians  

    齋藤 恒徳

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  • 研究賞

    2015年12月   高血圧と冠動脈疾患研究会  

    齋藤 恒徳

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  • Featured Poster Award from the 53rd Annual Scientific Session Exposition American College of Cardiology

    2004年3月   American College of Cardiology  

    齋藤 恒徳

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共同研究・競争的資金等の研究課題

  • 心筋細胞におけるマイトファジー活性化を標的とした拡張型心筋症の新規治療法開発

    研究課題/領域番号：24K11227  2024年4月 - 2027年3月

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    齋藤 恒徳

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    担当区分：研究代表者 

    配分額：4550000円 （ 直接経費：3500000円 、 間接経費：1050000円 ）

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  • 心筋細胞マイトファジーにおけるプレセニリン1および2の役割と相互作用の解明

    研究課題/領域番号：21KK0298  2022年 - 2024年

    日本学術振興会  科学研究費助成事業 国際共同研究加速基金(国際共同研究強化(A))  国際共同研究加速基金(国際共同研究強化(A))

    齋藤 恒徳

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    担当区分：研究代表者 

    配分額：15340000円 （ 直接経費：11800000円 、 間接経費：3540000円 ）

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  • 拡張型心筋症におけるオートファジー関連遺伝子変異の臨床的意義の解明

    研究課題/領域番号：20K08460  2020年4月 - 2024年3月

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    齋藤 恒徳

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    担当区分：研究代表者 

    配分額：4420000円 （ 直接経費：3400000円 、 間接経費：1020000円 ）

    オートファジーは細胞の自己成分を分解しアミノ酸として再利用する作用である。拡張型心筋症（DCM）の心筋障害の原因のひとつとしてオートファジー不全が考えられ、その遺伝学的特徴を調べるため、DCM患者におけるオートファジー関連遺伝子および心筋症関連遺伝子発現の全エクソーム解析による網羅的探索を行った。まずは少数例（32例）の解析を行い、以下に示すような結果が得られた。
    (1) オートファジー遺伝子、オートファジー関連遺伝子変異として、ATG2B、ATG9B、EPGの点突然変異を認めたが、全てvariant unknown significanceであった。（2）心筋症関連遺伝子変異の解析を行ったところ、18の病原性／準病原性遺伝子が17人の患者に認められた。特に、重症例にはTMEM43やDSPといった遺伝子変異を有するDCM患者の他に、既存の報告では比較的予後良好と報告されているMYBPC3変異を有する患者も認められた。（3）各遺伝子変異について電子顕微鏡画像と比較したところ、それぞれの変異を示唆する所見を示していた。このことから初発の心不全において比較的早期に得られた心内膜心筋生検の画像は遺伝子検査を行う方針決定に有用である可能性が示された。これらの内容は、それぞれ現在論文を投稿し、査読中となっている。

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  • 心筋細胞におけるオートファジーの分布・出現様式および調節機構の解明

    2019年3月 - 2021年3月

    日本心臓財団  第32回 日本心臓財団・バイエル薬品 海外留学助成 

    齋藤 恒徳

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    担当区分：研究代表者  資金種別：競争的資金

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  • 拡張型心筋症のオートファジー発現に関与する因子の探索

    2018年3月 - 2019年3月

    日本医科大学同窓会  日本医科大学同窓会医学研究助成 

    齋藤 恒徳

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    担当区分：研究代表者  資金種別：競争的資金

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  • 拡張型心筋症におけるオートファジーの検出と臨床的意義の解明

    2017年4月 - 2020年3月

    日本学術振興会  科学研究費 若手研究（B） 

    齋藤 恒徳

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    担当区分：研究代表者  資金種別：競争的資金

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  • 心房細動がもたらす心房筋リモデリングとバイオマーカとしてのmicroRNAの解明

    2016年4月 - 2019年3月

    日本学術振興会  科学研究費 基盤研究（C） 

    藤井 正大

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    資金種別：競争的資金

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