記述言語：日本語   出版者・発行元：日本結核・非結核性抗酸菌症学会関東支部学会・日本呼吸器学会関東地方会  

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記述言語：英語   出版者・発行元：LIPPINCOTT WILLIAMS & WILKINS  

Web of Science

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記述言語：英語   出版者・発行元：LIPPINCOTT WILLIAMS & WILKINS  

Web of Science

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記述言語：日本語   出版者・発行元：日本臨床外科学会  

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

Abdominal ultrasonography in a 70-year-old woman showed a hypoechoic mass, 14 mm in diameter, in the pancreatic body. Computed tomography showed a mass with contrast effect in the pancreatic body. Test results for endocrine factors or tumor markers were normal. The initial consideration was nonfunctional pancreatic neuroendocrine tumor. Over 8 years of monitoring, the tumor diameter increased to 18 mm, until pancreatic tumor enucleation was performed. The postoperative diagnosis was pancreatic hamartoma, a rare type of benign pancreatic tumor. The preoperative diagnosis of pancreatic hamartoma is difficult, but consideration must be given to the possibility of hamartoma when encountering pancreatic tumors.

DOI： 10.2169/internalmedicine.5982-20

PubMed

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記述言語：日本語   出版者・発行元：(一社)日本乳癌学会  

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

Breast cancer is the most common malignancy in women and has a risk of late recurrence. We report a case of metastasis to the stomach and colon 23 years after surgery, with characteristic findings. A 74-year-old woman underwent breast cancer resection at the age of 51. At the time, no additional therapy was performed despite the histological diagnosis of invasive lobular carcinoma with lymph node metastasis. Upper gastrointestinal endoscopy, which was performed as a follow-up for her chronic gastritis, revealed multiple erosions. Histology revealed diffuse proliferation of signet ring cell-like atypical cells, that were positive for cytokeratin CAM5.2 and estrogen receptor. These findings suggested metastasis from the invasive lobular breast carcinoma. Positron-emission tomography revealed sternal and vertebral metastases. Colonoscopy also performed to screen for intestinal metastasis revealed several lesions that resembled hyperplastic polyps. Although these lesions were not strongly suspected of metastasis, histology surprisingly revealed the same findings as the gastric metastasis. This case involved gastric and colorectal superficial metastases that were synchronously detected 23 years after primary treatment. We report that early-stage colorectal metastasis may resemble hyperplastic polyps, and biopsy should always be considered in patients with a history of breast cancer, regardless of years elapsed since treatment.

DOI： 10.1007/s12328-020-01285-3

PubMed

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記述言語：日本語   出版者・発行元：一般社団法人 日本膵臓学会  

<p>症例は65歳男性．検診で膵体部に腫瘤性病変を指摘され，精査加療目的で当院に紹介された．腹部造影CTで膵体部に動脈相で周囲膵組織より濃染される10mm×7mm大の腫瘤性病変を認め，病変近傍の主膵管狭窄および尾側の拡張を伴っていた．膵神経内分泌腫瘍（pNET）が疑われたが，主膵管の狭窄を伴う点が非典型的であり，超音波内視鏡下穿刺吸引術を施行した．病理結果はpNET G1であり，膵体尾部切除術が施行された．術後病理組織学的所見でchromogranin Aおよびsynaptophysinが陽性であったほか，serotoninが陽性であり，pNETと診断した．腫瘍は狭窄した主膵管を半周程度接して位置しており，腫瘍内部には強い線維化を認めた．膵管狭窄についてはserotoninの関与が疑われた．</p>

DOI： 10.2958/suizo.36.169

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is widely used as a first-line procedure for the definitive diagnosis of pancreatic solid tumor. Adverse events associated with the EUS-FNA procedure include acute pancreatitis, bleeding, infection, and duodenal perforation. Rarely, pancreatic tumors disseminate in the peritoneal cavity or seed in the gastric wall via the biopsy needle tract after EUS-FNA. Such seeding has been noted primarily in cases of adenocarcinomas and has not been associated with solid pseudopapillary neoplasm (SPN), a rare and potentially malignant tumor of the pancreas. This is the first report of a case of tumor seeding in the gastric wall after EUS-FNA of pancreatic SPN.

DOI： 10.2169/internalmedicine.3244-19

PubMed

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

The current study investigated the efficacy of podoplanin expression in tumor budding cells as a predictor of neck lymph node metastasis (NLM) in patients with tongue squamous cell carcinoma (SCC) of low tumor budding grade (TBG). A total of 99 patients with early T-stage tongue SCC of any clinical N status who received the initial curative treatment were enrolled. The association between podoplanin expression and NLM was immunohistochemically analyzed, with a focus on tongue SCC with low TBG. The disease-specific survival (DSS) rate was 77% at 5 years, and a significant difference was observed between the NLM-positive and NLM-negative groups, and between the low (n=77) and high (n=22) TBG groups. In the low TBG group, there was a significant difference in DSS between the NLM-positive and NLM-negative groups. The multivariate analysis showed that lymphatic vessel invasion (ly) [odds ratio (OR)=11.5, 95% confidence interval (CI): 1.50-87.6; P=0.02] and podoplanin expression (OR=7.07, 95% CI: 1.80-27.7; P=0.005) were significantly correlated with NLM. Furthermore, negative predictive values (NPV) of ly and podoplanin expression for NLM were 75% and 88%, respectively. Considering the balance of stratification case number adding to ratio, NLM-negative prediction by podoplanin was more significant than that by ly for the low TBG group. The results of the present study demonstrated that podoplanin expression in tumor budding is an independent and efficient predictor of NLM in the tongue SCC with low TBG. The low TBG and podoplanin-negative cases may be candidates for the wait and watch policy, therefore, reducing inappropriate elective neck lymph node dissections.

DOI： 10.3892/ol.2020.11358

Scopus

PubMed

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1055/a-0957-3005

PubMed

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記述言語：日本語   出版者・発行元：(公社)日本臨床細胞学会  

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掲載種別：研究論文（学術雑誌）   出版者・発行元：BMC  

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

Objectives While bile duct brush cytology during endoscopic retrograde cholangiopancreatography (ERCP) is a well-established procedure for detecting malignant biliary stricture, its sensitivity is reportedly low. We aimed to determine the pre-ERCP factors affecting brush cytology sensitivity. Methods We retrospectively analyzed 185 patients who underwent brush cytology during the first ERCP for undiagnosed biliary stricture at our institution between January 2014 and December 2016. We analyzed the relationship of age, sex, final diagnosis, stricture location, tumor size, stricture length, total bilirubin level, white blood cell count, and C-reactive protein level with brush cytology sensitivity. Results The following conditions were established as final diagnoses: benign disease, 19 cases (10.3%); intrahepatic cholangiocarcinoma, 10 cases (5.4%); hilar cholangiocarcinoma, 38 cases (20.5%); extrahepatic cholangiocarcinoma, 44 cases (23.8%); pancreatic cancer, 55 cases (29.7%); other malignant tumors, 19 cases (10.3%). The sensitivity and specificity of brush cytology were 60.8% and 94.7%, respectively. The stricture length, total bilirubin level, and white blood cell count in true-positive cases were significantly higher than those in false-negative cases. Furthermore, a stratified analysis of the bilirubin levels demonstrated that sensitivity was highest in patients with moderate jaundice (80% for a total bilirubin level of 10-20 mg/dL), but significantly lower in patients with severe jaundice (total bilirubin level ≥20 mg/dL). Conclusion While the sensitivity of brush cytology increases with bilirubin levels of up to 20 mg/dL, severe jaundice has a negative effect on sensitivity, warranting additional pathological examinations according to the pre-ERCP bilirubin level.

DOI： 10.2169/internalmedicine.1551-18

PubMed

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

The present case report describes a case of left renal clear cell carcinoma with brain, lung, para-aortic, and lymph node metastases (cT1bN1M1) in a 52-year-old Japanese male. The patient received sequential anticancer treatments with pazopanib, everolimus, and axitinib, but exhibited treatment-resistant tumor growth. Treatment with nivolumab resulted in a complete response in metastatic sites. However, the residual renal tumor, which was enhanced by contrast medium, required radical nephrectomy. Pathological analyses of the renal tumor revealed that it consisted of fibrotic and lymphocyte-infiltrated tissues in which morphological cancer cells were not detected. The majority of lymphocytes were cluster of differentiation (CD)8-positive, suggesting that cancer cells were attacked by these lymphocytes. Retrospective analyses of renal cell carcinoma tissues, which were biopsied before the anticancer treatment, revealed their infiltration by CD8-positive T cells. To the best of our knowledge, this is the first case report to examine renal tissue prior to and following treatment with nivolumab using immunohistochemical analysis.

DOI： 10.3892/mco.2018.1779

PubMed

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

The differential diagnosis of gastrointestinal subepithelial lesions (SELs) such as gastrointestinal stromal tumors from other benign tumors is important. In the present study, adequate sample rates of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) with a 22G Franseen needle for SELs were evaluated. The present study included 57 consecutive lesions (61 sessions) of EUS-FNA using a 22G needle to evaluate SELs between July 2013 and October 2017. Adequate sample rates were compared retrospectively between a 22G conventional needle group (C group) and a 22G Franseen needle group (F group). The overall adequate sample rate was 80.3%. The adequate sample rates in the C and F groups were 75.0% (33/44) and 94.1% (16/17), respectively (P=0.15). For lesions ≥20 mm, the adequate sample rates were 82.8% (24/29) in the C group and 91.7% (11/12) in the F group, 8.9% higher in the F group. However, for lesions <20 mm, the adequate sample rates were 60% (9/15) in the C group and 100% (5/5) in the F group, 40% higher in the F group (P=0.65, 0.26). In conclusion, the results of the present study suggested that using a 22G Franseen needle for EUS-FNA evaluation of SELs may improve adequate sample rates in small lesions <20 mm in diameter.

DOI： 10.3892/mco.2018.1709

PubMed

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Spandidos Publications  

Histone deacetylase (HDAC) inhibitor is known to have a cytotoxic effect on ovarian cancer cell lines. The present study analyzed the association between immunohistochemical HDAC expression and clinicopathological findings, in particular, the association with histological type and effect of chemotherapy. The histology of the 201 ovarian cancers addressed was as follows: Serous carcinoma (SEC), 100 cases
clear cell carcinoma (CCC), 56 cases
endometrioid carcinoma (EMC), 36 cases
and mucinous carcinoma (MUC), 9 cases. Immunohistochemical analyses of HDACs 1, 2, 3, 4, 5, 6 and 7 expression levels were performed using tissue microarrays, composed of 201 primary tumors and 38 tumors following chemotherapy. Overexpression of HDAC1 was detected in the nucleus of all cases with MUC, followed by CCC (80%), SEC (73%), and EMC (53%). CCC specifically demonstrated HDAC7 expression in both the nucleus (27%) and the cytoplasm (54%), and HDAC6 expression in the nucleus (34%). The comparison between prior to and following chemotherapy revealed a nuclear expression increase in HDAC1 (76% vs. 92%
P=0.03) and HDAC7 (0.0 vs. 16%
P=0.01), and cytoplasmic expression increase in HDAC6 (40 vs. 74%
P=&lt
0.01) and HDAC7 (16 vs. 66%
P=&lt
0.01). HDAC1 nuclear expression adversely affected overall survival in SEC (P=0.02) and EMC (P=0.03), and HDAC7 cytoplasmic expression in CCC was associated with a poor prognosis (P=0.06). In multivariate analysis, HDAC6 nuclear expression was determined as a poor prognostic factor (hazard ratio=3.51
95% confidence interval, 1.49 to 8.27, P=&lt
0.01). In the subgroup analysis, HDAC6 nuclear expression was associated with a poor prognosis in CCC (P=0.07), International Federation of Obstetrics and Gynecology stage III/IV (P=0.07), and suboptimal surgery (P=&lt
0.01). In conclusion, HDACs may be associated with the prognosis of ovarian cancers, depending on the histological subtypes, and upregulated following chemotherapy. HDAC1, 6 and 7 may therefor act as promising therapeutic targets in the future.

DOI： 10.3892/ol.2018.7726

Scopus

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.vgie.2017.11.010

PubMed

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掲載種別：研究論文（学術雑誌）  

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.gie.2017.04.033

PubMed

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掲載種別：研究論文（学術雑誌）  

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：LIPPINCOTT WILLIAMS & WILKINS  

Granular cell tumors are uncommon neoplasms and a small number of these neoplasms have been reported as showing malignant behavior. Here, we report a rare case of a solitary granular cell tumor that exhibited atypical histology, including an extensive desmoplastic stroma, in a 69-year-old woman. The surgical specimen revealed localized areas of spindling cells, areas of cellular pleomorphism, and p53 overexpression. Based on previously published criteria, we classified this lesion as an atypical granular cell tumor. To date, only very few case reports have documented this desmoplastic variant of granular cell tumor. However, the classifications of benign, atypical, and malignant granular cell tumors are still controversial, owing to an overlap of morphological and immunohistochemical profiles and lack of consistent histological criteria. Additionally, it is unknown whether the histology of the desmoplastic variant in the present case is significant for the classification of granular cell tumors and prediction of patient prognosis. Regardless of these issues, awareness, and close follow-up are required because of potential recurrences of this rare variant of granular cell tumor.

DOI： 10.1097/DAD.0000000000000760

Web of Science

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掲載種別：研究論文（学術雑誌）  

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記述言語：日本語   掲載種別：研究論文（学術雑誌）   出版者・発行元：一般社団法人 日本消化器内視鏡学会  

<p>患者は70歳代の女性．20年以上前より食道アカラシアと診断されていたが嚥下障害の増悪と誤嚥性肺炎を認めた．食道アカラシアは進行シグモイド型（aSg型），Ⅱ度と診断した．また，上部消化管内視鏡検査で胸部上部食道に発赤を伴う0-Ⅱc病変を認め生検にて扁平上皮癌と診断された．NBI（Narrow band imaging）併用拡大内視鏡検査ではbrownish area内にループ様の異常血管を認め深達度T1a（LPM）と診断した．食道表在癌に対するESDを先行施行した．病理検査結果では深達度T1a（LPM），ly0，v0であり内視鏡的治癒切除と判断した．４カ月後に食道アカラシアに対して腹腔鏡下手術を施行した．経過良好で，術後８年の現在において食道癌，食道アカラシアともに再発所見は認めていない．</p>

DOI： 10.11280/gee.59.1403

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掲載種別：研究論文（学術雑誌）   出版者・発行元：学研メディカル秀潤社  

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掲載種別：研究論文（学術雑誌）   出版者・発行元：学研メディカル秀潤社  

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掲載種別：研究論文（学術雑誌）   出版者・発行元：学研メディカル秀潤社  

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掲載種別：研究論文（学術雑誌）   出版者・発行元：学研メディカル秀潤社  

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掲載種別：研究論文（学術雑誌）   出版者・発行元：学研メディカル秀潤社  

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：SPRINGER  

The aim of this study was to investigate the prevalence of Lynch syndrome among Japanese patients with surgically resected colorectal cancer at a single institution.
Of 616 colorectal cancer patients who underwent surgical operation in our institution from January 2005 to August 2010, immunohistochemistry analyses for mismatch repair proteins (MLH1, MSH2, MSH6, and PMS2) and microsatellite instability (MSI) testing for surgically resected, formalin-fixed paraffin-embedded colorectal cancer specimens from 138 colorectal cancer patients under 60 years of age were undertaken. Hypermethylation of the MLH1 promoter and BRAF mutation were analyzed where necessary.
Seven patients were identified as candidates for genetic testing by mismatch repair protein loss (n = 7) or MSI-H (n = 6). Methylation of MLH1 was detected in one case. Three patients were diagnosed with Lynch syndrome, comprising 2.2 % of the total colorectal cancer patients younger than 60 years of age.
The prevalence of Lynch syndrome among hospital-based diagnosed cancer patients may therefore be lower than expected in Japan compared with Western populations.

DOI： 10.1007/s00595-015-1232-1

Web of Science

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記述言語：日本語   掲載種別：研究論文（学術雑誌）   出版者・発行元：医学書院  

CiNii Books

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その他リンク： http://search.jamas.or.jp/link/ui/2016076057

掲載種別：研究論文（学術雑誌）  

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掲載種別：研究論文（学術雑誌）  

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掲載種別：研究論文（学術雑誌）   出版者・発行元：医学書院  

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記述言語：日本語   掲載種別：研究論文（学術雑誌）   出版者・発行元：日本臨床外科学会  

症例は90歳，男性．24年前に直腸カルチノイドに対して直腸低位前方切除術施行歴があった．無症状であったが，健診目的の胸部レントゲンで右胸水疑いと指摘されたのをきっかけにCTが施行され，肝S5に腫瘤性病変を認めた．CT上胸部には異常所見を認めなかった．当初は肝内胆管癌を考慮したが，高齢であることを踏まえ肝S5部分切除術を施行した．病理組織学的検査で直腸neuroendocrine tumor （NET）と診断され，24年前に手術施行した直腸カルチノイドの肝転移と判断された．術後7カ月経過現在，無再発生存中である．直腸カルチノイドは一般に低悪性度といわれるが進行が緩徐であることを踏まえ，直腸カルチノイド治療歴のある患者に対しては長期経過後の再発もありうることを念頭に置きつつ診療にあたることが重要と思われる．

DOI： 10.3919/jjsa.76.2263

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その他リンク： http://search.jamas.or.jp/link/ui/2015405509

記述言語：日本語   掲載種別：研究論文（学術雑誌）   出版者・発行元：日本臨床外科学会  

腸管子宮内膜症は，S状結腸や直腸発生が主であり小腸発生は稀である．今回，繰り返す腸閉塞症状に対して精査し回腸末端の狭窄を認めたため手術となった症例で，所属リンパ節内に卵管内膜組織を認めた回腸子宮内膜症の症例を経験した．症例は50歳，女性．数カ月前より腸閉塞を発症し，精査するも原因不明であったが腸閉塞が再燃したため入院となった．腹部CT検査にて，回腸末端に腫瘤を疑う所見および拡張した小腸を認めたものの，確定診断には至らなかったため試験開腹術を施行した．手術時回腸末端漿膜に引きつれおよび硬結を認め回盲部切除術を施行した．摘出標本の病理所見では，回腸の漿膜下層から粘膜下層に立方ないし円柱上皮からなる大小の腺管と，腺管周囲に紡錘形細胞からなる間質組織を認めた．所属リンパ節内にも立方上皮からなる腺管組織を認め，所属リンパ節内に異所性卵管内膜組織病変を伴った回腸子宮内膜症による腸閉塞と最終診断された．

DOI： 10.3919/jjsa.76.2220

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その他リンク： http://search.jamas.or.jp/link/ui/2015405501

掲載種別：研究論文（学術雑誌）   出版者・発行元：日本臨床  

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記述言語：日本語   掲載種別：研究論文（学術雑誌）   出版者・発行元：医学書院  

CiNii Books

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その他リンク： http://search.jamas.or.jp/link/ui/2015046823

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：The Japanese Society for Lymphoreticular Tissue Research  

A 35-year-old man was referred to our hospital because of left supraclavicular and cervical lymphadenopathies. Histopathological examination of the lymph nodes revealed reactive lymphadenopathy. He visited our hospital three years after the initial diagnosis because of enlarged left cervical lymph nodes. Histopathologically, both Hodgkin/Reed-Sternberg (H/RS) and lymphocyte-predominant (LP) cells were found in the lymph node. We first suspected nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL), because these cells were CD15^- and CD30^-. However, the diagnosis of lymphocyte-rich classical Hodgkin lymphoma (LRCHL) was finally confirmed, because these cells were found to be CD20^-, Bob.1⁺, Oct.2^-, and BCL6^- by additional immunostaining. The patient was treated with six cycles of ABVD chemotherapy, and a complete response was achieved. However, he underwent autologous stem-cell transplantation after high-dose chemotherapy owing to a relapse 10 months after primary treatment. Distingushing LRCHL from NLPHL was difficult in this patient, because histopathological examination showed both H/RS and LP cells, and immunostaining revealed these cells to be triple negative (CD15^-, CD30^- and CD20^-). Accumulation of such cases are necessary to establish better criteria for the differential diagnosis and assessment of clinical behavior.

DOI： 10.3960/jslrt.55.23

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その他リンク： http://search.jamas.or.jp/link/ui/2016174984

掲載種別：研究論文（学術雑誌）   出版者・発行元：医学書院  

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掲載種別：研究論文（学術雑誌）   出版者・発行元：医学書院  

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記述言語：日本語   掲載種別：研究論文（学術雑誌）   出版者・発行元：京都府立医科大学  

CiNii Books

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その他リンク： http://search.jamas.or.jp/link/ui/2014307872

掲載種別：研究論文（学術雑誌）  

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掲載種別：研究論文（学術雑誌）  

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掲載種別：研究論文（学術雑誌）   出版者・発行元：日本病理学会  

大腸ポリープには組織学的に上皮性の管状腺腫、管状絨毛腺腫、絨毛腺腫、鋸歯状腺腫、広基性鋸歯状腺腫や腺癌、カルチノイドや内分泌癌などの神経内分泌系のほか、炎症性、過誤腫(症候)性、間質性(間葉系)、リンパ組織性など、さまざまな種類の病変がみられる。さらに、近年の大腸内視鏡検査の普及と共に病変の新たな知見が得られてきた。過形成性ポリープ、鋸歯状腺腫、広基性鋸歯状腺腫はBRAFやKRAS遺伝子異常との関連に基づいて鋸歯状病変として再編され、fibroblastic polypはperineuriomaと同一の病変であることが明らかにされてきている。今後も症例の蓄積が進むと共に、新たな病変が見出されたり疾患概念が構築されると思われる。そのためにも正しい病理診断を行うことが重要と考えられる。

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掲載種別：研究論文（学術雑誌）   出版者・発行元：文光堂  

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掲載種別：研究論文（学術雑誌）  

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記述言語：日本語   掲載種別：研究論文（学術雑誌）   出版者・発行元：医学書院  

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その他リンク： http://search.jamas.or.jp/link/ui/2013338152

記述言語：日本語   掲載種別：研究論文（学術雑誌）   出版者・発行元：一般社団法人 日本消化器内視鏡学会  

【背景・目的】胃腺腫と高分化型腺癌を内視鏡的に鑑別することは非常に困難なのが現状である．胃腺腫と高分化型腺癌の鑑別が必要と考えられる病変群に対してNarrow Band Imaging（NBI）併用拡大観察を施行し，われわれの提唱するType分類が胃腺腫と高分化型腺癌の鑑別に有用かを前向きに検討した．<BR>【方法】2008年11月～2009年12月までの14カ月間に3施設にて内視鏡治療を予定された胃上皮性腫瘍のうち，胃腺腫と高分化型腺癌の鑑別が必要な病変93例を対象とした．<BR>NBI併用拡大観察における粘膜微細構造と微小血管像の複合所見から当院提唱のType分類を行い，Type I，IIは胃腺腫，IIIからVは高分化型腺癌と内視鏡治療前に診断し，術後の病理組織の結果との正診率を前向きに検討した．<BR>【結果】93例中87例が5つのTypeに分類可能であったが，われわれのType分類では分類不能な症例が6例存在した．Type別の内訳はType I：16例，Type II：12例，Type III：29例，Type IV：27例，Type V：3例であった．Type I・IIを術前に腺腫と診断した場合，正診率は79％．Type III～Vを高分化型癌と診断した場合の正診率は93％であった．<BR>【結論】NBI観察に基づくType分類は，胃腺腫と高分化型腺癌の内視鏡的鑑別に有用である．

DOI： 10.11280/gee.55.2050

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掲載種別：研究論文（学術雑誌）  

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掲載種別：研究論文（学術雑誌）  

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掲載種別：研究論文（学術雑誌）  

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掲載種別：研究論文（学術雑誌）  

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：International College of Surgeons  

This retrospective study investigated the clinicopathologic characteristics and clinical outcomes of esophageal basaloid squamous carcinoma (BSC). Among 190 patients with esophageal carcinoma treated surgically between 1998 and 2011, we identified 9 (4.7%) with BSC. All of the patients were male, with a median age of 65 years. The frequencies of venous invasion, lymphatic invasion, and lymph node metastasis were 56%, 89%, and 67%, respectively. A total of 2 patients were pathologic stage 1, 5 were stage 2, and 2 were stage 3. Tumor recurrence was observed in 56% of the patients. The 5-year survival rate for patients with esophageal BSC was 40%, which was compatible with the figure of 53.8% for control patients (n=18) with typical squamous cell carcinoma matched for sex, age, tumor location, and pathologic stage (P = 0.45). Although esophageal BSC shows aggressive lymph-vascular invasion and has a high likelihood of recurrence, its prognosis seems identical to that of typical squamous cell carcinoma.

DOI： 10.9738/CC195

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掲載種別：研究論文（学術雑誌）  

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掲載種別：研究論文（学術雑誌）  

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

Recently, we reported a case of gastric mucosa-associated lymphoid tissue (MALT) lymphoma presenting with unique vascular features. In the report, we defined the tree-like appearance (TLA) on the images of abnormal blood vessels which resembled branches from the trunk of a tree in the shiny mucosa, in which the glandular structure was lost. The 67-year-old female was diagnosed with gastric MALT lymphoma. The patient received eradication therapy for H. pylori. Conventional endoscopy revealed multiple ill-delineated brownish depressions in the stomach and cobblestone-like mucosa was observed at the greater curvature to the posterior wall of the upper gastric body 7 mo after successful eradication. Unsuccessful treatment of gastric MALT lymphoma was suspected on conventional endoscopy. Conventional endoscopic observations found focal depressions and cobblestone-like appearance, and these lesions were subsequently observed using magnified endoscopy combined with narrow band imaging to identify abnormal vessels presenting with a TLA within the lesions. Ten biopsies were taken from the area where abnormal vessels were present within these lesions. Ten biopsies were also taken from the lesions without abnormal vessels as a control. A total of 20 biopsy samples were evaluated to determine whether the diagnosis of MALT lymphoma could be obtained histologically from each sample. A positive diagnosis was obtained in 8/10 TLA (+) sites and in 2/10 TLA(-) sites. Target biopsies of the site with abnormal blood vessels can potentially improve diagnostic accuracy of gastric MALT lymphoma.

DOI： 10.4253/wjge.v4.i4.151

PubMed

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掲載種別：研究論文（学術雑誌）  

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：SPRINGER TOKYO  

The interpretation of colonic biopsies related to inflammatory conditions can be challenging because the colorectal mucosa has a limited repertoire of morphologic responses to various injurious agents. Only few processes have specific diagnostic features, and many of the various histological patterns reflect severity and duration of the disease. Importantly the correlation with endoscopic and clinical information is often cardinal to arrive at a specific diagnosis in many cases.

DOI： 10.1007/s00535-012-0539-6

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記述言語：日本語   掲載種別：研究論文（学術雑誌）   出版者・発行元：一般社団法人 日本消化器内視鏡学会  

【目的】われわれが胃のIIa様病変の診断に有用であると報告しているNBI Type分類が，胃腺腫と分化型腺癌の鑑別が必要な褪色調陥凹性病変に対しても有用であるかを検討する．【方法】2008年11月からの16カ月間に，当科にて通常観察及びNBI併用拡大観察を施行した症例の中で，生検Group IIIの褪色調陥凹性病変9例を対象とした．われわれが提唱するType分類を試み，切除標本の病理結果と比較した．同時期に観察しえた隆起型褪色調病変（生検Group III）59例との比較も行った．【結果】切除標本の病理結果は9例すべて高分化型腺癌．NBI併用拡大観察所見はType I：0例，II：0例，III：2例，IIIs：3例，IV：4例．褪色調隆起性病変の中でも陥凹を有するIIa＋IIcのような病変とはNBI所見等で類似点を認めた．【結論】当院提唱のNBI Type分類が褪色調陥凹性病変の良悪性鑑別にも有用である可能性が示唆された．

DOI： 10.11280/gee.54.11

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：COLLEGE AMER PATHOLOGISTS  

DOI： 10.5858/arpa.2011-0376-LE

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：BIOMED CENTRAL LTD  

We present a 69-year-old woman with a chief complaint of postmenopausal bleeding. She was diagnosed as having an endometrioid adenocarcinoma by biopsy, and underwent a total abdominal hysterectomy. At the time of surgery, granulation tissue-like nodules were found on the peritoneal serosa of the uterus. In the intraoperative cytology of peritoneal washing, atypical cells were noted. The intraoperative frozen section of the peritoneal nodule revealed granulation tissue with proliferating mesothelial cells. Microscopic examination of the permanent section showed keratin granulomas without viable adenocarcinoma cells on the serosal surface of the ovaries, fallopian tubes and broad ligaments. Postoperative chemotherapy was administered. She has been alive with no evidence of recurrence for 6 months postoperatively. It should be noted that the prognosis of cases in peritoneal keratin granuloma without viable cancer cells is favorable, and that the histological examination is essential for its diagnosis.

DOI： 10.1186/1746-1596-6-104

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掲載種別：研究論文（学術雑誌）  

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掲載種別：研究論文（学術雑誌）  

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：WILEY-BLACKWELL  

Background and Aim:
Presently, the differential diagnosis of gastric adenoma and well-differentiated adenocarcinoma by endoscopy is very difficult. We carried out magnifying endoscopy with narrow band imaging (NBI) in lesions that required discrimination between gastric adenoma and well-differentiated adenocarcinoma, and prospectively evaluated whether the tumor typing that we propose is useful for their differential diagnosis.
Methods:
The materials were 93 lesions that required differential diagnosis between gastric adenoma and well-differentiated adenocarcinoma among the gastric epithelial tumors for which endoscopic treatment was planned at three facilities during the 14 months between November 2008 and December 2009. According to the typing method proposed by our facility based on images of the mucosal ultrastructure and microvessels obtained by magnified endoscopy combined with NBI, type I-II and type III-V lesions were diagnosed as gastric adenoma and well-differentiated adenocarcinoma, respectively, before endoscopic treatment, and the accuracy of the diagnoses were prospectively examined by comparing them with the postoperative pathological findings.
Results:
Of the 93 lesions, 87 could be typed into the five types of our typing method, but six lesions could not be classified. The 87 lesions consisted of 16 type I, 12 type II, 29 type III, 27 type IV, and three type V lesions. The percentages of accurate preoperative diagnoses of types I-II as adenoma and types III-V as well-differentiated adenocarcinoma were 79% and 93%, respectively.
Conclusions:
The tumor typing based on NBI was useful for the endoscopic differentiation of gastric adenoma and well-differentiated adenocarcinoma.

DOI： 10.1111/j.1443-1661.2010.01070.x

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掲載種別：研究論文（学術雑誌）  

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掲載種別：研究論文（学術雑誌）  

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掲載種別：研究論文（学術雑誌）  

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掲載種別：研究論文（学術雑誌）  

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掲載種別：研究論文（学術雑誌）  

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掲載種別：研究論文（学術雑誌）  

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掲載種別：研究論文（学術雑誌）  

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掲載種別：研究論文（学術雑誌）  

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：SPRINGER JAPAN KK  

The development of modern endoscopic techniques, easier and greater access to healthcare, and interest in Helicobacter pylori infection and its implications have all led to a significant increase in upper endoscopies. In turn, gastroenterologists and pathologists have been recognizing an ever-increasing number of patterns of mucosal injury. Consequently, there is now an interest in a wider aspect of non-neoplastic gastric pathology, namely, non-HP (H. pylori) gastritis. In this review, we present major clinico-pathological entities, based on either the salient morphological features or the underlying etiologies.

DOI： 10.1007/s00535-009-0146-3

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：WILEY-BLACKWELL PUBLISHING, INC  

Recently, dermoscopic visualization has been improved, allowing for the identification of malignant melanoma (MM) of the sole in situ. When the parallel ridge pattern is evident on dermoscopy, the proliferation of solitarily arranged melanocytes in the crista profunda intermedia should be examined histologically, since this may be a clue to the early diagnosis of MM in situ. We reviewed 145 Japanese cases of melanocytic nevus on the sole, and investigated several useful histological features for the diagnosis of MM in situ using a recent proposal as well as several standard histological criteria of MM in situ. Five cases were considered to be an early-stage MM in situ out of 145 cases previously diagnosed as melanocytic nevi of the sole. These cases showed several specific features, including solitarily arranged melanocytes or melanocyte nests comprising fewer than four cells. Our findings indicate that early-stage MM of the sole in situ can be diagnosed by using new dermoscopy-related histological findings. They are (i) irregular distribution of solitary melanocytes at the crista profunda intermedia with or without small nests (up to three melanocytes) on the slope of rete ridges; and (ii) larger melanocytes with a halo around the nucleus.

DOI： 10.1111/j.1440-1827.2009.02483.x

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掲載種別：研究論文（学術雑誌）  

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掲載種別：研究論文（学術雑誌）  

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記述言語：日本語   掲載種別：研究論文（学術雑誌）   出版者・発行元：一般社団法人 日本消化器内視鏡学会 関東支部  

A 73-year-old male patient underwent esophagectomy and reconstruction using a colon via antethoracic route for esophageal cancer in 1994. He had been followed up with an upper gastrointestinal endoscopy for five years after surgery. He presented to his family physician with fever and coughing. His doctor introduced him to the department of the pulmonary disease at our hospital because of the elevation of CEA and CYFRA. He received CT and PET. PET showed SUV uptake in colonic interposition. He received an upper gastrointestinal endoscopy and laterally spreading tumors were identified. These lesions were considered a good candidate for endoscopic resection. The lesions were safely and completely removed by ESD and EMR. Histological examination diagnosed the specimen as high grade tubular adenoma. The patient was hospitalized for 4 days after endoscopic treatment to confirm the absence of complications such as delayed perforation and bleeding, and was then discharged.<br> Upper endoscopic screening is recommended after five years follow up of colonic interposition and lesions may be detected early and removed safely by endoscopy.

DOI： 10.11641/pde.77.2_60

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記述言語：日本語   掲載種別：研究論文（学術雑誌）   出版者・発行元：一般社団法人 日本消化器内視鏡学会 関東支部  

A 73-year-old male patient underwent esophagectomy and reconstruction using a colon via antethoracic route for esophageal cancer in 1994. He had been followed up with an upper gastrointestinal endoscopy for five years after surgery. He presented to his family physician with fever and coughing. His doctor introduced him to the department of the pulmonary disease at our hospital because of the elevation of CEA and CYFRA. He received CT and PET. PET showed SUV uptake in colonic interposition. He received an upper gastrointestinal endoscopy and laterally spreading tumors were identified. These lesions were considered a good candidate for endoscopic resection. The lesions were safely and completely removed by ESD and EMR. Histological examination diagnosed the specimen as high grade tubular adenoma. The patient was hospitalized for 4 days after endoscopic treatment to confirm the absence of complications such as delayed perforation and bleeding, and was then discharged.<br> Upper endoscopic screening is recommended after five years follow up of colonic interposition and lesions may be detected early and removed safely by endoscopy.

DOI： 10.11641/pde.77.2_60

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：ELSEVIER SCIENCE INC  

We investigated the presence of lymphatic invasion detected by D2-40 immunostaining compared to conventional hematoxylin-eosin (HE) staining in primary pancreatic cancer. We also compared the alkaline phosphatase-fast red detection method with the 3,3&apos;-diaminobenzidine (DAB) detection method. We reviewed 25 cases of pancreatic cancer with lymph node (LN) metastases and 15 cases without LN metastases and evaluated the detection rate of lymphatic invasion by HE stain slide alone and D2-40 immunostains. Regarding the cases with positive LN metastasis, 4 (16%) of the 25 cases showed lymphatic invasion by HE slide alone, whereas 7 cases (28%) demonstrated positive lymphatic invasion by D2-40 immunostain. On the other hand, even in cases with negative LN metastasis, 3 of the 15 cases revealed lymphatic invasion by D2-40 immunostaining. Lymphatic invasion was easily detected by alkaline phosphatase-fast red technique, especially at the lower magnification. Regarding the location of lymphatic invasion, it was recognized not only at the peripheral portion but also in the central part of the tumors by D2-40 immunostains; this was difficult to identify by HE stain slide alone. Our study indicates that lymphatic invasion may be overlooked when only HE stain slides are used. In addition, the alkaline phosphatase-fast red detection method (vivid red color) is a distinctive advantage compared with the DAB detection method (brown color), especially in detecting lymphatic invasion at the lower magnification. (C) 2009 Elsevier Inc. All rights reserved.

DOI： 10.1016/j.anndiagpath.2009.03.002

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：SPRINGER  

Focal nodular hyperplasia (FNH) of the liver is considered to develop as a hyperplastic response to a preexisting vascular abnormality. From the pathogenic point of view, we studied histological alterations in the extranodular background liver tissue of FNH (FNH-bg-liver). We compared ten FNH-bg-livers with ten non-FNH cases (non-FNH-liver) and found small uniform nodule formations with ring-like siderosis in the FNH-bg-livers (4/7, 57%) but not in the non-FNH-livers. Abnormal small arteries not accompanied by portal tracts were observed in six of six FNH-bg-livers for which immunohistochemical study was available, while this was observed in only three of the ten non-FNH-livers. CD34-positive sinusoids around the portal tracts were observed in only the FNH-bg-livers (3/6, 50%). Further, two of ten FNH-bg-livers had ectopic pancreatic tissue. Ring-like siderosis, abnormal small arteries, CD34-positive sinusoids, and ectopic pancreatic tissue were characteristic in the extranodular background liver tissue in cases of FNH.

DOI： 10.1007/s00428-009-0743-9

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掲載種別：研究論文（学術雑誌）  

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記述言語：英語   出版者・発行元：SPRINGER TOKYO  

With regard to the esophagus, the term "squamous dysplasia" has been used in European countries, the United States, and China, while its use is controversial in Japan. Recently, "low-grade intraepithelial neoplasia" and "high-grade intraepithelial neoplasia" have been used as inclusive terms for dysplasia and carcinoma in situ in the World Health Organization classification. Endoscopically, it is often difficult to identify squamous intraepithelial neoplasia by conventional endoscopy, but application of iodine is useful for the diagnosis of such a lesion. In addition, new types of endoscopic techniques, including magnifying endoscopy, narrow-band imaging (NBI), and endocytoscopy are helpful to detect squamous intraepithelial neoplasia. NBI is very useful for identifying the intrapapillary capillary loop pattern. Regarding the pathological criteria of squamous dysplasia and squamous cell carcinoma, the views of Japanese and Western pathologists have differed significantly. Before the term "intraepithelial neoplasia" was introduced, severe dysplasia as diagnosed by Western pathologists was in fact the same as squamous cell carcinoma in situ or noninvasive carcinoma as diagnosed by Japanese pathologists. This problem has been solved by the introduction of the Vienna classification; however, there are still some issues that need to be resolved. One of them is the presence of basal layer type squamous cell carcinoma in situ, which is often underdiagnosed as lowgrade intraepithelial neoplasia by Western pathologists. Endoscopic treatments such as endoscopic mucosal resection and endoscopic submucosal dissection have recently become possible choices for squamous intraepithelial neoplasia; however, these techniques are not in widespread use in the West. We believe that a consensus meeting between Japanese and Western pathologists as well as endoscopists should be held promptly to reach a common ground for the nomenclature.

DOI： 10.1007/s00535-008-2298-y

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掲載種別：研究論文（学術雑誌）  

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掲載種別：研究論文（学術雑誌）  

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：SPRINGER TOKYO  

In this review article, we demonstrate the mucin expression profile in normal tissue, invasive ductal carcinoma (IDC), two subtypes of intraductal papillary-mucinous neoplasm (IPMN dark cell type and IPMN clear cell type), pancreatic intraepithelial neoplasia (PanIN), and mucinous cystic neoplasm (MCN) of the pancreas. In MUC1, there are various glycoforms, such as poorly glycosylated MUC1, sialylated MUC1, and fully glycosylated MUC1. IDCs showed high expression of all the glycoforms of MUC1. IPMNs dark cell type showed no expression or low expression of all the glycoforms of MUC1. IPMNs clear cell type showed low expression of poorly glycosylated MUC1, but expression of sialylated MUC1 and fully glycosylated MUC1. Expression of MUC2 was negative in IDCs, high in IPMNs dark cell type and low in IPMNs clear cell type. MUC5AC was highly expressed in IDCs, IPMNs dark cell type, and IPMNs clear cell type. MUC6 expression was higher in IPMNs clear cell type than in IDCs and IPMNs dark cell type. Our recent study demonstrated that high expression of MUC4 in IDCs is correlated with a poor outcome for patients. In PanINs, expression of both MUC5AC and MUC6 are an early event, whereas up-regulation of MUC1 is a late event. MCNs do not look as if they will show a specific mucin expression profile according to the literature review.

DOI： 10.1007/s00534-006-1169-2

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記述言語：日本語   掲載種別：研究論文（学術雑誌）   出版者・発行元：The Japan Society of Coloproctology  

直腸肛門部悪性黒色腫は稀な疾患で, 予後不良である. 今回, 外科的切除と免疫監視療法により, 長期生存が得られた症例を経験したので報告する.<br>症例は69歳の女性で, 下血を主訴に来院. 下部消化管内視鏡検査で直腸肛門部悪性黒色腫が疑診され, 1998年1月局所切除施行. 病理診断は悪性黒色腫で, 1998年2月直腸切断術およびリンパ節廓清を施行した. 術後の病理診断では, 腫瘍の残存やリンパ節転移は認めなかったが, その後異時的に小腸, 心嚢傍脂肪織, 左腋窩リンパ節, 臀部脂肪織に再発を認め, 各々に対して外科的切除を施行した. 8年1カ月経過した2006年2月現在, 再発徴候なく経過観察中である.<br>転移を併発した悪性黒色腫は予後不良であるが, 自験例では早期発見および積極的な外科的切除が有効であったと考えられた.

DOI： 10.3862/jcoloproctology.60.146

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その他リンク： http://search.jamas.or.jp/link/ui/2007150693

掲載種別：研究論文（学術雑誌）  

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：TAYLOR & FRANCIS INC  

A 7-month-old infant was noted to have vaginal bleeding that was accompanied by a discharged tumor fragment. The histological diagnosis was endodermal sinus tumor. Her serum alpha-fetoprotein (AFP) was increased to 358.7 ng/mL, and magnetic resonance imaging showed a 1.8 x 1.0 cm tumor in the vagina. She received combination chemotherapy with cyclophosphamide, pirarubicin, carboplatin, and etoposide. The tumor in the images disappeared and the serum level of AFP returned to the normal range after 2 cycles. Treatment was complete without surgical or radiological therapy. More than 45 months after the completion of chemotherapy, she is alive without signs of recurrence.

DOI： 10.1080/08880010600856972

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記述言語：日本語   掲載種別：研究論文（学術雑誌）   出版者・発行元：一般社団法人日本消化器外科学会  

同時性多発肝・骨転移を認めた直腸腺扁平上皮癌を経験したので報告する.症例は73歳の女性で,便柱狭小化と腰痛を主訴に来院した.直腸Rs領域に半周性の3型病変を認め,生検で低分化腺病と診断された.同時に遠隔リンパ節転移,肝両葉にわたる多発肝転移,第1仙椎への転移も認められた.局所に関しては出血,狭窄症状のコントロール目的でHartmann手術を施行した.痛理組織学的検査で,直腸腺扁平上皮癌,Rs, Type3, ss, ly3, v3, n2, H3, P0, M1でStage IVと診断された.術後化学療法は大腸癌に準じて5-FUによる肝動注,CPT-11と1-LVによる全身化学療法および骨転移に放射線治療を行った.本疾患はまれで,いまだ確立された治療法はないが,多発転移を伴う直腸腺扁平上皮癌に対して今後,薬剤感受性試験や分子生物・遺伝子学的方法による補助療法の工夫が必要と考えられた.

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掲載種別：研究論文（学術雑誌）  

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掲載種別：研究論文（学術雑誌）  

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：BLACKWELL PUBLISHING ASIA  

Our previous immunohistochemical studies in the pancreas, intrahepatic bile duct, and ampulla of Vater demonstrated that an invasive carcinoma with a poor outcome showed a pattern of MUC1 (membrane-bound mucin) positive and MUC2 (intestinal-type secretory mucin) negative, whereas many of the non-invasive tumors with favorable outcome showed a pattern of MUC1 negative and MUC2 positive. The aim of this study is to compare the expression profiles of MUC1 and MUC2 mucins in extrahepatic bile duct carcinomas to gain insight into the relationship between the biological nature of the carcinomas and the role of mucins. We examined the expression profiles of MUC1 of different glycoforms and MUC2 in 60 extrahepatic bile duct carcinomas using immunohistochemistry. The expression of MUC1/CORE (core peptide of MUC1), MUC1/DF3 (core peptide of MUC1 with sialyl oligosaccharides) and MUC1/MY.1E12 (sialylated MUC1) showed a significant relationship with tumor progression factors such as poor differentiation, deep invasion, lymph node metastasis, lymphatic invasion or perineural invasion. In contrast, the expression of MUC1/HMFG-1 (fully glycosylated MUC1) did not show a significant relationship with the tumor progression factors. In the different glycoforms of MUC1 examined, the expression of MUC1/DF3 and MUC1/MY.1E12 was related with the poor outcome of the patients. In contrast, the expression of MUC2 was inversely related with the tumor progression factors and poor outcome. In the 52 patients with advanced tumors, only MUC1/DF3 high expression correlated with poor prognosis. In conclusion, MUC1/DF3 was the most useful prognosis indicator among the various glycoforms of MUC1 mucins.

DOI： 10.1046/j.1440-1827.2002.01414.x

Web of Science

PubMed

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記述言語：日本語   出版者・発行元：Japanese Society for Molecular Tumor Marker Research  

DOI： 10.11241/jsmtmr.18.61

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担当ページ：230-238   著書種別：学術書

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記述言語：日本語   出版者・発行元：(公社)日本臨床細胞学会  

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記述言語：日本語   出版者・発行元：(公社)日本臨床細胞学会  

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記述言語：日本語   出版者・発行元：日本医科大学医学会  

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記述言語：日本語   出版者・発行元：日本医科大学医学会  

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記述言語：英語   出版者・発行元：(一社)日本病理学会  

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記述言語：日本語   出版者・発行元：(一社)日本病理学会  

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J-GLOBAL

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語   出版者・発行元：腎癌研究会  

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記述言語：日本語   出版者・発行元：(一社)日本病理学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(一社)日本リンパ網内系学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(公社)日本臨床細胞学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(一社)日本病理学会  

J-GLOBAL

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語   出版者・発行元：医学書院  

CiNii Books

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その他リンク： http://search.jamas.or.jp/link/ui/2016074511

記述言語：日本語   出版者・発行元：医学書院  

CiNii Books

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その他リンク： http://search.jamas.or.jp/link/ui/2015342122

記述言語：日本語  

J-GLOBAL

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記述言語：日本語  

J-GLOBAL

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記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）   出版者・発行元：MOSBY-ELSEVIER  

Web of Science

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記述言語：日本語   出版者・発行元：日本臨床外科学会  

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(一社)日本消化器内視鏡学会  

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記述言語：日本語   出版者・発行元：(一社)日本大腸肛門病学会  

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記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）   出版者・発行元：MOSBY-ELSEVIER  

Web of Science

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記述言語：日本語   出版者・発行元：一般社団法人日本外科学会  

CiNii Books

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出版者・発行元：文光堂  

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記述言語：日本語   出版者・発行元：一般社団法人日本消化器外科学会  

CiNii Books

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記述言語：日本語   出版者・発行元：(一社)日本大腸肛門病学会  

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記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）   出版者・発行元：MOSBY-ELSEVIER  

Web of Science

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記述言語：日本語   出版者・発行元：一般社団法人日本外科学会  

CiNii Books

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記述言語：日本語   出版者・発行元：特定非営利活動法人日本臨床細胞学会  

CiNii Books

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記述言語：日本語   出版者・発行元：特定非営利活動法人日本臨床細胞学会  

CiNii Books

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記述言語：日本語   出版者・発行元：特定非営利活動法人日本臨床細胞学会  

CiNii Books

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記述言語：日本語   出版者・発行元：特定非営利活動法人日本臨床細胞学会  

CiNii Books

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記述言語：英語   出版者・発行元：(一社)日本病理学会  

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記述言語：日本語   出版者・発行元：(一社)日本病理学会  

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記述言語：日本語   出版者・発行元：鹿児島大学  

CiNii Books

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その他リンク： http://hdl.handle.net/10232/6571

記述言語：日本語   出版者・発行元：日本組織細胞化学会  

CiNii Books

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その他リンク： http://search.jamas.or.jp/link/ui/2006048320

記述言語：日本語   出版者・発行元：特定非営利活動法人日本臨床細胞学会  

CiNii Books

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記述言語：日本語   出版者・発行元：特定非営利活動法人日本臨床細胞学会  

CiNii Books

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記述言語：日本語   出版者・発行元：特定非営利活動法人日本臨床細胞学会  

CiNii Books

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記述言語：日本語   出版者・発行元：一般社団法人日本消化器外科学会  

CiNii Books

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開催地：東京  

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開催地：札幌  

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開催地：岩手  

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開催地：福岡  

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開催地：名古屋  

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開催地：名古屋  

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開催地：東京  

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開催地：横浜  

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開催地：福岡  

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開催地：新潟  

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開催地：東京都新宿区  

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開催地：東京都新宿区  

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開催地：兵庫県神戸市  

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開催地：Washington, DC  

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開催地：東京都新宿区  

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開催地：東京都新宿区  

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開催地：福岡県久留米市  

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開催地：福岡県久留米市  

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開催地：兵庫県神戸市  

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開催地：大阪  

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開催地：Colorado, USA  

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開催地：金沢  

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開催地：京都  

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開催地：札幌  

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開催地：大阪  

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開催地：大阪  

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開催地：京都  

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開催地：京都  

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開催地：京都  

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開催地：Vancouver, BC, Canada  

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開催地：青森  

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開催地：神奈川県横浜  

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開催地：兵庫県神戸市  

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開催地：兵庫県神戸市  

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開催地：San Antonio, USA  

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開催地：大阪，大阪国際会議場  

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