Updated on 2024/11/23

写真a

 
Endoh Ikuko
 
Affiliation
Tamanagayama Hospital, Clinical Laboratory, Assistant Professor
Title
Assistant Professor
External link

Research Interests

  • 炎症

  • S100A8蛋白

  • 多核白血球

  • 循環器学

Research Areas

  • Life Science / Cardiology

Education

  • University of New South Wales   degree of Doctor of Philosophy

    2004.4 - 2008.3

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  • Nippon Medical School   Medical School

    1992.4 - 1998.3

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Research History

  • Nippon Medical School   Assistant Professor

    2008.6

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  • University of New South Wales

    2003.5 - 2008.5

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  • Nippon Medical School

    1998.5 - 2003.4

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Professional Memberships

  • The Japanese Circulation Society

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  • JAPANESE SOCIETY OF LABORATORY MEDICINE

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Papers

  • Effect of smoking status on monocyte tissue factor activity, carotid atherosclerosis and long-term prognosis in metabolic syndrome Reviewed

    Keiichi Kohashi, Akihiro Nakagomi, Taichirou Morisawa, Ikuko Endoh, Naomi Kawaguchi, Yoshiki Kusama, Wataru Shimizu

    Circulation Journal   82 ( 5 )   1418 - 1427   2018

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    Language：English   Publisher：Japanese Circulation Society  

    Background: Smoking increases the risk of atherothrombotic events. Tissue factor (TF) mainly expressed on monocytes plays an important role in thrombosis and atherosclerosis. Metabolic syndrome (MetS) is being increasingly recognized as a major atherothrombotic risk factor, but the effects of smoking on monocyte TF activity (MTFA), carotid atherosclerosis estimated on carotid intima-media thickness (CIMT), and long-term prognosis in MetS remain unclear. Methods and Results: A total of 301 MetS patients lacking any known cardiovascular disease were prospectively investigated and classified into 4 groups according to smoking status at entry and at 12 months as follows: never smokers, past smokers, quitters, and persistent smokers. Peripheral blood mononuclear cells (PBMC) were isolated, and MTFA was measured using a coagulation assay. Linear trends for higher baseline MTFA and CIMT were observed among persistent smokers, quitters, and past smokers compared with never smokers. At 12 months, MTFA and CIMT decreased in never and past smokers and quitters but increased in persistent smokers. Six acute myocardial infarctions and 8 strokes occurred during a median follow-up of 66.0 months. Persistent smoking was associated with an increased risk of events (P&lt
    0.001). Conclusions: Smoking is associated with upregulated MTFA and progression of CIMT, which may be related to the risk of atherothrombotic events in MetS patients.

    DOI： 10.1253/circj.CJ-17-0644

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    Other Link： https://search.jamas.or.jp/default/link?pub_year=2018&ichushi_jid=J04756&link_issn=&doc_id=20180509280031&doc_link_id=10.1253%2Fcircj.CJ-12-0125&url=https%3A%2F%2Fdoi.org%2F10.1253%2Fcircj.CJ-12-0125&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

  • Nutritional Status is Associated with Inflammation and Predicts a Poor Outcome in Patients with Chronic Heart Failure Reviewed

    Akihiro Nakagomi, Keiichi Kohashi, Taichirou Morisawa, Munenori Kosugi, Ikuko Endoh, Yoshiki Kusama, Hirotsugu Atarashi, Wataru Shimizu

    JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS   23 ( 6 )   713 - 727   2016

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：JAPAN ATHEROSCLEROSIS SOC  

    Aim: Malnutrition has been identified to be an independent predictor of morbidity and mortality in patients with chronic heart failure (CHF). However, the pathophysiological mechanisms underlying this pathway remain unclear.
    Methods: Nutritional screening was performed using the controlling nutritional status (CONUT) score, which was calculated using the serum albumin and total cholesterol levels and lymphocyte number, in 114 CHF patients with a mean left ventricular ejection fraction of 26.6% +/- 6.4%. The carotid intima-media thickness (CIMT) is correlated with carotid atherosclerosis and is a significant predictor of future cardiovascular events. Peripheral blood mononuclear cells (PBMCs) were isolated, and the production of monocyte tumor necrosis factor (TNF)-alpha was measured and expressed as mean +/- SD (pg/mL/10(6) PBMCs).
    Results: A multivariate linear regression analysis showed that the production of monocyte TNF-alpha (beta coefficient = 0.434, p< 0.001) and mean CIMT (beta coefficient = 0.204, p= 0.006) were independent determinants of the CONUT score. During a median follow-up of 67.5 months, 45 patients experienced cardiac events, including 16 cardiac deaths and 29 readmissions for worsening CHF. A multivariate Cox hazard analysis demonstrated that a monocyte TNF-alpha level of >= 4.1 pg/mL/106 PBMCs (hazard ratio (HR), 14.10; 95% confidence interval (CI), 2.55-77.92; p = 0.002) and CONUT score of = 3 (HR, 11.97; 95% CI, 2.21-64.67; p = 0.004) were independently associated with the incidence of cardiac events.
    Conclusions: These data indicate that a poor nutritional status as assessed using the CONUT score and atherosclerosis as indicated by CIMT is significantly associated with inflammation and predicts poor outcomes in patients with CHF.

    DOI： 10.5551/jat.31526

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  • Olanzapine-Related Life-Threatening Hyperosmolar Hyperglycemic Syndrome A Case Report Reviewed

    Ikuko Endoh, Eitaro Kodani, Masatomo Yoshikawa, Yasumi Endoh, Yoshiki Kusama, Hirotsugu Atarashi

    JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY   32 ( 1 )   130 - 132   2012.2

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：LIPPINCOTT WILLIAMS & WILKINS  

    DOI： 10.1097/JCP.0b013e318240a472

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  • S100A8 Modulates Mast Cell Function and Suppresses Eosinophil Migration in Acute Asthma Reviewed

    Jing Zhao, Ikuko Endoh, Kenneth Hsu, Nicodemus Tedla, Yasumi Endoh, Carolyn L. Geczy

    ANTIOXIDANTS & REDOX SIGNALING   14 ( 9 )   1589 - 1600   2011.5

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：MARY ANN LIEBERT, INC  

    S100A8 is implicated in the pathogenesis of inflammatory diseases. S100A8 is upregulated in macrophages by Toll-like receptors (TLR)-3, 4, and 9 agonists in an IL-10-dependent manner, and by corticosteroids in vitro and in vivo, and scavenges oxidants generated by activated phagocytes. Because if its elevated expression in various lung disorders, we asked whether S100A8 was protective in allergic inflammation. S100A8, but not Cys(41)-Ala S100A8, in which the single reactive Cys residue was replaced by Ala, reduced mast cell (MC) degranulation and production of particular cytokines (IL-6, IL-4, and granulocyte macrophage colony-stimulating factor) in response to IgE-crosslinking in vitro, likely by inhibiting intracellular reactive oxygen species production, thereby reducing downstream linker for activation of T cells and extracellular signal regulated kinase/mitogen-activated protein kinase phosphorylation. In lungs of mice with acute asthma, S100A8, but not Cys(41)-Ala S100A8, reduced MC degranulation, production of eosinophil chemoattractants (IL-5, eotaxin, and monocyte chemoattractant protein-1), and eosinophil infiltration. Suppression of IL-6 and IL-13 could have contributed to reduced mucus production seen in lungs of S100A8-treated mice. IgE production was unaffected. In asthma, there is an imbalance of anti-oxidant systems that are generally protective. Our results strongly support a protective role for S100A8 in allergic inflammation by modulating MC activation and eosinophil recruitment, and by scavenging oxidants generated by activated leukocytes, in processes reliant on its thiol-scavenging capacity. Antioxid. Redox Signal. 14, 1589-1600.

    DOI： 10.1089/ars.2010.3583

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  • Inflammation and Atrial Fibrillation Reviewed

    Yasumi Endoh, Ikuko Endoh, Akihiro Nakagomi, Yoshiki Kusama, Hirotsugu Atarashi, Carolyn Geczy, Hirotsugu Atarashi

    Journal of Arrhythmia   27 ( 2 )   106 - 115   2011

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    Language：English   Publishing type：Research paper (scientific journal)  

    Atrial fibrillation (AF) is the most common sustained arrhythmia encountered in clinical practice. Accumulating evidence indicates a link between inflammation and AF, and important advances in understanding mechanisms of AF are arising from studies of the critical components involved in the modulation of the immunoinflammatory balance within the atrium. However, molecular mechanisms remain unclear. Indeed, although preclinical and clinical studies suggest that chronic inflammation may promote development of AF, the roles of inflammation in the process are complex and incompletely understood. The purpose of this review is to briefly highlight current evidence on relationships between inflammation and AF, and to discuss possible mechanisms of development of AF and/or possible therapeutic approaches targeting components of the inflammatory response. © 2011, Japanese Heart Rhythm Society. All rights reserved.

    DOI： 10.4020/jhrs.27.106

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  • Ultraviolet B irradiation selectively increases the production of interleukin-8 in human cord blood-derived mast cells Reviewed

    I. Endoh, N. Di Girolamo, T. Hampartzoumian, B. Cameron, C. L. Geczy, N. Tedla

    CLINICAL AND EXPERIMENTAL IMMUNOLOGY   148 ( 1 )   161 - 167   2007.4

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：BLACKWELL PUBLISHING  

    UVB irradiation modulates immune responses in the skin and is a major cause of sunburn, during which neutrophils accumulate in the skin. Because of their abundance in skin and ability to produce a variety of proinflammatory mediators, we propose that mast cells may play a key role in ultraviolet B (UVB)-induced skin inflammation. Cord blood-derived human mast cells were treated in vitro with varying doses of UVB and production of multiple cytokines was measured in culture supernatants. UVB exposure significantly increased the release of interleukin (IL)-8 and modestly increased IL-1 alpha production, but cytokines such as IL-2, IL-4, IL-6, IL-10, IL-12, IL-13, tumour necrosis factor (TNF)-alpha and interferon (IFN)-gamma were unaffected. Cycloheximide reduced the UVB-mediated induction of IL-8 by 30-40%, suggesting that new protein synthesis contributed to IL-8 production. In line with this, UVB treatment of mast cells significantly increased IL-8 mRNA. In contrast to its effect on IL-8 production, optimal doses of UVB did not provoke histamine or tryptase release, indicating little effect on degranulation. Our data suggest that mast cells may play a major role during UVB-induced acute inflammation by selectively inducing cytokines involved in neutrophil recruitment.

    DOI： 10.1111/j.1365-2249.2007.03332.x

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  • Serum amyloid A induces monocyte tissue factor Reviewed

    Hong Cai, Changjie Song, Ikuko Endoh, Jesse Goyette, Wendy Jessup, S. Ben Freedman, H. Patrick McNeil, Carolyn L. Geczy

    JOURNAL OF IMMUNOLOGY   178 ( 3 )   1852 - 1860   2007.2

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：AMER ASSOC IMMUNOLOGISTS  

    C-reactive protein (CRP) and serum amyloid A (SAA) increase in the blood of patients with inflammatory conditions and CRP-induced monocyte tissue factor (TF) may contribute to inflammation-associated thrombosis. This study demonstrates that SAA is a potent and rapid inducer of human monocyte TF. SAA induced TF mRNA in PBMC within 30 min and optimal procoagulant activity within 4 h, whereas CRP (25 mu g/ml)-induced activity was minimal at this time. Unlike CRP, SAA did not synergize with LPS. Procoagulant activity was inhibited by anti-TF and was dependent on factors VII and X, and TF Ag levels were elevated on CD14(+) monocytes. Responses were optimal with lymphocytes, although these were not obligatory. Inhibitor studies indicate activation of NF-kappa B through the ERK1/2 and p38 MAPK pathways; the cyclo-oxygenase pathway was not involved. SAA-induced TF was partially inhibited by high-density lipoprotein, but not by low-density lipoprotein or by apolipoprotein A-I. SAA is a ligand for the receptor for advanced glycation end products (RAGE), and TF generation was suppressed by similar to 50% by a RAGE competitor, soluble RAGE, and by similar to 85% by anti-RAGE IgG. However, another RAGE ligand, high mobility group box-1 protein, capable of inducing monocyte chemotactic protein-1 mRNA in 2 h, did not induce TIT within 24 h. Cross-linking studies confirmed SAA binding to soluble RAGE. Elevated SAA is a marker of disease activity in patients with rheumatoid arthritis, and PBMC from patients with rheumatoid arthritis were more sensitive to SAA than normals, suggesting a new link between inflammation and thrombosis.

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Books

  • New mechanisms of regulation of mast cell activation

    Ikuko Endoh（ Role： Sole author）

    University of New South Wales  2007 

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Misc.

  • 臨地実習ガイドライン改定に伴う包括的サポートシステム運用の試み

    輿石 大地, 加藤 政利, 中島 愛, 四田 千穂美, 鳴海 武長, 大堀 昂平, 遠藤 育子, 金子 朋広

    日本医学検査学会抄録集   73回   229 - 229   2024.5

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    Language：Japanese   Publisher：(一社)日本臨床衛生検査技師会  

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  • 臨地実習ガイドライン更新に伴う実習プログラム事前運用の試み

    輿石 大地, 加藤 政利, 中島 愛, 四田 千穂美, 遠藤 育子, 金子 朋宏

    Kameraden   ( 73 )   15 - 15   2023.11

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    Language：Japanese   Publisher：私立医科大学臨床検査技師会  

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  • メタボリックシンドローム患者において、喫煙が単球組織因子活性、頸動脈アテローム硬化および長期予後に及ぼす影響(Effects of Smoking on the Monocyte Tissue Factor Activity, Carotid Atherosclerosis and the Long-Term Prognosis in Patients with Metabolic Syndrome)

    中込 明裕, 小橋 啓一, 森澤 太一郎, 遠藤 育子, 川口 直美, 草間 芳樹, 清水 渉

    日本循環器学会学術集会抄録集   81回   OJ - 192   2017.3

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  • 糖尿病を合併する慢性心不全患者においてdipeptidyl peptide-4阻害薬が炎症、心機能、長期予後に及ぼす影響(Impacts of Dipeptidyl Peptide-4 Inhibitors on the Inflammation, Cardiac Function and Long-term Prognosis of Chronic Heart Failure Patients with Diabetes)

    Kohashi Keiichi, Nakagomi Akihiro, Morisawa Taichirou, Kosugi Munenori, Endoh Ikuko, Kawaguchi Naomi, Kusama Yoshiki, Shimizu Wataru

    Circulation Journal   80 ( Suppl.I )   1154 - 1154   2016.3

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  • Febuxostatとallopurinolが高尿酸血症を合併する慢性心不全患者の炎症および心機能に及ぼす作用(Effects of Febuxostat and Allopurinol on the Inflammation and Cardiac Function in Chronic Heart Failure Patients with Hyperuricemia)

    Nakagomi Akihiro, Morisawa Taichirou, Kohashi Keiichi, Saiki Yoshiyuki, Kosugi Munenori, Endoh Ikuko, Kawaguchi Naomi, Endoh Yasumi, Kusama Yoshiki, Shimizu Wataru

    Circulation Journal   80 ( Suppl.I )   1158 - 1158   2016.3

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  • メタボリックシンドローム患者における喫煙状態が炎症および内皮機能に及ぼす影響(Impact of Smoking Status on the Inflammation and Endothelial Function in Patients with Metabolic Syndrome)

    Nakagomi Akihiro, Morisawa Taichirou, Kohashi Keiichi, Kosugi Munenori, Endoh Ikuko, Kawaguchi Naomi, Endoh Yasumi, Kusama Yoshiki, Shimizu Wataru

    Circulation Journal   80 ( Suppl.I )   743 - 743   2016.3

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  • 高コレステロール血症患者の単球組織因子活性と頸動脈アテローム性動脈硬化症の進展に対するatorvastatinおよびpitavastatinの異なる作用(Differential Effects of Atorvastatin and Pitavastatin on the Monocyte Tissue Factor Activity and Progression of Carotid Atherosclerosis in Hypercholesterolemic Patients)

    Nakagomi Akihiro, Noma Satsuki, Morisawa Taichirou, Kohashi Keiichi, Kosugi Munenori, Murata Hiroshige, Endoh Ikuko, Kusama Yoshiki, Atarashi Hirotsugu, Shimizu Wataru

    Circulation Journal   79 ( Suppl.I )   1156 - 1156   2015.3

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  • 慢性心不全患者における栄養状態は炎症と有意に関連し、転帰不良が予測される(The Nutritional Status is Significantly Associated with Inflammation and Predicts Poor Outcomes in Patients with Chronic Heart Failure)

    Nakagomi Akihiro, Noma Satsuki, Morisawa Taichirou, Kohashi Keiichi, Kosugi Munenori, Endoh Ikuko, Kusama Yoshiki, Atarashi Hirotsugu, Shimizu Wataru

    Circulation Journal   79 ( Suppl.I )   1605 - 1605   2015.3

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  • 冠動脈疾患患者においてosteoprotegerin上昇は内皮機能障害と関連し早期頸動脈アテローム硬化を予測する(Elevated Osteoprotegerin is Associated with Endothelial Dysfunction and Predicts Early Carotid Atherosclerosis in Patients with Coronary Artery Disease)

    Morisawa Taichirou, Nakagomi Akihiro, Kohashi Keiichi, Kosugi Munenori, Endoh Ikuko, Kusama Yoshiki, Atarashi Hirotsugu, Shimizu Wataru

    Circulation Journal   79 ( Suppl.I )   1710 - 1710   2015.3

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  • Eicosapentaenoic acidが慢性心不全患者のmyeloperoxidase、心機能、長期予後に及ぼす影響(Effects of Eicosapentaenoic Acid on the Myeloperoxidase, Cardiac Function and Long-term Prognosis in Patients with Chronic Heart Failure)

    Kohashi Keiichi, Nakagomi Akihiro, Morisawa Taichirou, Kosugi Munenori, Endoh Ikuko, Kusama Yoshiki, Atarashi Hirotsugu, Shimizu Wataru

    Circulation Journal   79 ( Suppl.I )   704 - 704   2015.3

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  • 慢性心不全において単球組織因子活性のアップレギュレーションは炎症および内皮機能障害と関連し、転帰不良が予測される(Upregulated Monocyte Tissue Factor Activity is Associated with Inflammation and Endothelial Dysfunction and Predicts Poor Outcomes in Chronic Heart Failure)

    Noma Satsuki, Nakagomi Akihiro, Kohashi Keiichi, Kosugi Munenori, Endoh Ikuko, Kawaguchi Naomi, Endoh Yasumi, Kusama Yoshiki, Atarashi Hirotsugu, Shimizu Wataru

    Circulation Journal   78 ( Suppl.I )   160 - 160   2014.3

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  • C-reactive proteinによる単球からの炎症性サイトカイン産生のアップレギュレーションは慢性心不全患者の予後不良を予測する(Upregulation of Monocyte Proinflammatory Cytokines Production by C-Reactive Protein Predicts Poor Outcomes in Patients with Chronic Heart Failure)

    Nakagomi Akihiro, Noma Satsuki, Kohashi Keiichi, Kosugi Munenori, Endoh Ikuko, Kawaguchi Naomi, Endoh Yasumi, Kusama Yoshiki, Seino Yoshihiko, Atarashi Hirotsugu, Shimizu Wataru

    Circulation Journal   78 ( Suppl.I )   306 - 307   2014.3

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  • 慢性心不全患者において単球interleukin-8産生のアップレギュレーションから転帰不良が予測される(Up-regulated Monocyte Interluekin-8 Production Predicts Poor Outcomes in Patients with Chronic Heart Failure)

    Nakagomi Akihiro, Noma Satsuki, Kohashi Keiichi, Kosugi Munenori, Endoh Ikuko, Kawaguchi Naomi, Endoh Yasumi, Kusama Yoshiki, Atarashi Hirotsugu, Shimizu Wataru

    Circulation Journal   78 ( Suppl.I )   76 - 77   2014.3

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  • 慢性心不全患者においてeicosapentaenoic acidがadiponectin、心機能、長期予後に及ぼす作用(Effects of Eicosapentaenoic Acid on Adiponectin, Cardiac Function, and the Long-Term Prognosis in Chronic Heart Failure Patients)

    Kohashi Keiichi, Nakagomi Akihiro, Noma Satsuki, Morisawa Taichirou, Kosugi Munenori, Endoh Ikuko, Kawaguchi Naomi, Endoh Yasumi, Kusama Yoshiki, Atarashi Hirotsugu, Shimizu Wataru

    Circulation Journal   78 ( Suppl.I )   108 - 108   2014.3

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  • AtorvastatinとPravastatinが高コレステロール血症患者のインシュリン感受性、酸化ストレスマーカー、頸動脈アテローム性動脈硬化症の進行に及ぼす作用は異なる(Differential Effects of Atorvastatin and Pravastatin on Insulin Sensitivity, Oxidative Stress Markers and Progression of Carotid Atherosclerosis in Hypercholesterolemic Patients)

    Nakagomi Akihiro, Shibui Toshiyuki, Noma Satsuki, Kohashi Keiichi, Saiki Yoshiyuki, Kosugi Munenori, Endoh Ikuko, Kawaguchi Naomi, Endoh Yasumi, Kusama Yoshiki, Atarashi Hirotsugu, Shimizu Wataru

    Circulation Journal   78 ( Suppl.I )   360 - 360   2014.3

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  • 失神発作を反復したダントロレン服用中の高齢者の1例

    遠藤 康実, 遠藤 育子, 川口 直美, 草間 芳樹, 新 博次, 畝本 恭子, 二宮 宣文

    心電図   33 ( Suppl.1 )   S - 27   2013.3

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    Language：Japanese   Publisher：(一社)日本不整脈心電学会  

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  • メタボリックシンドローム患者においてfenofibrateが単球による単球走化性蛋白質1産生と頸動脈アテローム性硬化症の進行に及ぼす影響(Effects of Fenofibrate on Monocyte Chemoattractant Protein-1 Production by Monocytes and Progression of Carotid Atherosclerosis in Patients with Metabolic Syndrome)

    Nakagomi Akihiro, Saiki Yoshiyuki, Kohashi Keiichi, Kosugi Munenori, Endoh Ikuko, Kawaguchi Naomi, Endoh Yasumi, Kusama Yoshiki, Atarashi Hirotsugu, Mizuno Kyoichi

    Circulation Journal   77 ( Suppl.I )   61 - 61   2013.3

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  • 高コレステロール血症患者においてatorvastatinおよびpitavastatinが炎症マーカー、酸化ストレスマーカー、頸動脈硬化症に及ぼす多面的効果は異なる(Differential Pleiotropic Effects of Atorvastatin and Pitavastatin on Inflammatory and Oxidative Stress Markers, and Carotid Atherosclerosis in Hypercholesterolaemic Patients)

    Nakagomi Akihiro, Saiki Yoshiyuki, Kohashi Keiichi, Kosugi Munenori, Endoh Ikuko, Kawaguchi Naomi, Endoh Yasumi, Kusama Yoshiki, Atarashi Hirotsugu, Mizuno Kyoichi

    Circulation Journal   77 ( Suppl.I )   17 - 17   2013.3

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  • 慢性心不全患者においてeicosapentaenoic acidが炎症マーカー、心機能、長期予後に及ぼす影響(Effects of Eicosapentaenoic Acid on Inflammatory Markers, Cardiac Function, and the Long-term Prognosis in Chronic Heart Failure Patients)

    Kohashi Keiichi, Nakagomi Akihiro, Saiki Yoshiyuki, Kosugi Munenori, Endoh Ikuko, Endoh Yasumi, Kusama Yoshiki, Atarashi Hirotsugu, Mizuno Kyoichi

    Circulation Journal   77 ( Suppl.I )   43 - 43   2013.3

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  • 慢性心不全患者において血清EPA/AA比は予後推定に有用である

    小橋 啓一, 中込 明裕, 西城 由之, 小杉 宗範, 遠藤 育子, 草間 芳樹, 新 博次, 水野 杏一

    日本心臓病学会誌   7 ( Suppl.I )   275 - 275   2012.8

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  • 慢性心不全患者における血清エイコサペンタエン酸/アラキドン酸比の予後的価値(Prognostic Value of the Serum Eicosapentaenoic Acid to Arachidonic Acid Ratio in Patients with Chronic Heart Failure)

    Kohashi Keiichi, Nakagomi Akihiro, Saiki Yoshiyuki, Kosugi Munenori, Endoh Ikuko, Endoh Yasumi, Kusama Yoshiki, Atarashi Hirotsugu, Mizuno Kyoichi

    Circulation Journal   76 ( Suppl.I )   1634 - 1634   2012.3

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  • Fenofibrateはメタボリックシンドローム患者における単球組織因子活性を軽減し、頸動脈アテローム性動脈硬化の進行を遅らせる(Fenofibrate Attenuates Monocyte Tissue Factor Activity and Slows Down Progression of Carotid Atherosclerosis in Patients with Metabolic Syndrome)

    Nakagomi Akihiro, Kohashi Keiichi, Saiki Yoshiyuki, Kosugi Munenori, Endoh Ikuko, Endoh Yasumi, Kusama Yoshiki, Atarashi Hirotsugu, Mizuno Kyoichi

    Circulation Journal   76 ( Suppl.I )   922 - 922   2012.3

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  • The review of indication to implantable cardioverter defibrillator(ICD) for resuscitated patients from sudden cardiac death with ventricular fibrillation, complicated with vasospastic angina and suspected any other arrhythmogenic substrate

    Homma Hanae, Endoh Ikuko, Matsumoto Shin, Endoh Yasumi, Nakagomi Akihiro, Igawa Osamu, Kusama Yoshiki, Atarashi Hirotsugu, Kodani Eitaro, Kikuchi Arifumi, Kosugi Munenori, Kato Katsuhito, Shindoh Asako, Shibui Toshiyuki, Okazaki Reiko, Yoshikawa Masatomo

    Shinzo   43 ( Suppl.2 )   149 - 153   2011.8

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    Language：Japanese   Publisher：公益財団法人 日本心臓財団  

    症例は53歳, 男性. フィットネスジムでジョギング中に心肺停止となり, インストラクターによるバイスタンダー心肺蘇生法(CPR), 自動体外式除細動器(AED)にて蘇生され, 当院救命救急センターに搬送された. AEDの解析結果では, 心室細動(VF)に対して除細動が作動した後, 完全房室ブロックを経て洞調律に復帰した記録を認めた. 冠動脈に有意狭窄なく, アセチルコリン(ACh)負荷試験にて左前下行枝起始部に攣縮を認め冠攣縮性狭心症と診断した. 本例は, 突然死の家族歴があり, 心臓MRIにおいてガドリニウム(Gd)遅延造影効果を認めたため冠攣縮以外の不整脈原性基質の存在を否定し得ず, 植込み型除細動器(ICD)の植込みを行った.<BR>VFを契機に発症した冠攣縮性狭心症では, VFの原因が冠攣縮によるものとは限らず, ICDの適応に関しては, 冠拡張薬の有効性に加え, 心筋症などの冠攣縮以外の不整脈原性基質を考慮することも重要である. 当院で経験した類似症例7例の臨床経過を含め, 冠攣縮性狭心症を有するがそのほかの不整脈原性基質が否定できない症例に対するICDの適応に関して考察した.

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  • 発熱を契機としてTorsade de pointesを来たした高齢者の1例

    遠藤 康実, 遠藤 育子, 岡崎 怜子, 松本 真, 草間 芳樹, 新 博次, 水野 杏一

    日本老年医学会雑誌   48 ( 4 )   422 - 422   2011.7

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    Language：Japanese   Publisher：(一社)日本老年医学会  

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  • 肥満細胞活性化とS100A8遺伝子発現修飾を調節する新機構(New Mechanisms of Regulation of Mast Cell Activation and Modulation of S100A8 Gene Expression)

    遠藤 康実, 遠藤 育子

    日本医科大学医学会雑誌   5 ( 4 )   251 - 251   2009.10

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    Language：English   Publisher：日本医科大学医学会  

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  • S100A8-An oxidant scavenger and immune modulator in allergic inflammation

    Carolyn L. Geczy, Lincoln Gomes, Mark Raftery, Jing Zhao, Ikuko Endoh, Yasumi Endoh, Paul Thomas

    CYTOKINE   48 ( 1-2 )   40 - 40   2009.10

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    Language：English   Publishing type：Research paper, summary (international conference)   Publisher：ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD  

    DOI： 10.1016/j.cyto.2009.07.352

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  • オランザピンにより発症した糖尿病性ケトアシドーシスの1例

    遠藤 育子, 小谷 英太郎, 吉川 雅智, 遠藤 康実, 佐野 純子, 中込 明裕, 草間 芳樹, 新 博次

    日本内科学会関東地方会   563回   18 - 18   2009.6

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    Language：Japanese   Publisher：日本内科学会-関東地方会  

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  • PE-163 Regulation of Mast Cell Function by the Pleiotropic Inflammatory Mediator, S100A8(PE028,Heart Failure, Basic (M),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

    Endoh Ikuko, Endoh Yasumi, Tedla Nicodemus, Xhao Jing, Goyette Jesse, Geczy Carolyn

    Circulation journal : official journal of the Japanese Circulation Society   73   440 - 440   2009.3

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    Language：English   Publisher：Japanese Circulation Society  

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  • DPE-005 Upregulation of Monocyte Tissue Factor Activity of Metabolic Syndrome Contributes to the Pathogenesis of Acute Coronary Syndrome(DPE01,Metabolic Syndrome (H),Digital Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

    Nakagomi Akihiro, Shibui Toshiyuki, Endoh Ikuko, Hirasawa Yasuhiro, Kodani Eitaro, Endoh Yasumi, Kusama Yoshiki, Atarashi Hirotsugu, Morikawa Masako, Mizuno Kyoichi

    Circulation journal : official journal of the Japanese Circulation Society   73   357 - 357   2009.3

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  • OE-053 Statin Therapy Attenuates Monocyte Tumor Necrosis Factor Production and Improves Cardic Function and Long-term Prognosis in Chronic Heart Failure(OE09,Heart Failure (Treatment) 1 (M),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

    Nakagomi Akihiro, Shibui Toshiyuki, Endoh Ikuko, Kodani Eitaro, Endoh Yasumi, Kusama Yoshiki, Seino Yoshihiko, Atarashi Hirotsugu, Mizuno Kyoichi

    Circulation journal : official journal of the Japanese Circulation Society   73   187 - 187   2009.3

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  • 免疫学的変化と疾患 HMG-CoA還元酵素阻害薬は心不全患者における単球上炎症性サイトカインの発現を抑制する

    渋井 俊之, 中込 明裕, 平澤 泰宏, 遠藤 育子, 岩崎 雄樹, 山根 吉人, 青木 聡, 遠藤 康実, 清野 精彦, 高野 照夫

    Journal of Nippon Medical School   71 ( 3 )   228 - 229   2004.6

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    Language：Japanese   Publisher：日本医科大学医学会  

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  • 炎症と心血管疾患 C反応性蛋白は心不全患者の単球上に炎症性サイトカインを誘導し,心不全悪化に関与する

    中込 明裕, 清野 精彦, 遠藤 育子, 平澤 泰宏, 川嶋 修司, 山根 吉人, 高木 元, 高野 仁司, 青木 聡, 遠藤 康実, 浅井 邦也, 安武 正弘, 草間 芳樹, 高山 守正, 高野 照夫

    日本冠疾患学会雑誌   9 ( 4 )   198 - 198   2003.11

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    Language：Japanese   Publisher：(NPO)日本冠疾患学会  

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