Updated on 2025/03/12

写真a

 
Tomoko Nagamine
 
Affiliation
Nippon Medical School Hospital, Department of Endocrinology, Diabetes and Metabolism, Assistant Professor
Title
Assistant Professor
External link

Research Areas

  • Life Science / Metabolism and endocrinology

Papers

  • 先端巨大症における術後早期の腎機能の変化

    富山 敬子, 福田 いずみ, 羽田 幹子, 井関 陽平, 長峯 朋子, 田原 重志, 岩部 真人

    日本内分泌学会雑誌   100 ( Suppl.HPT )   25 - 26   2024.8

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    Language:Japanese   Publisher:(一社)日本内分泌学会  

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  • HLA investigation in ICI-induced T1D and isolated ACTH deficiency including meta-analysis. International journal

    Mayo Ono, Mototsugu Nagao, Haruki Takeuchi, Etsuya Fukunaga, Tomoko Nagamine, Kyoko Inagaki, Izumi Fukuda, Masato Iwabu

    European journal of endocrinology   191 ( 1 )   9 - 16   2024.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    OBJECTIVE: Widespread use of immune checkpoint inhibitors (ICIs) in cancer treatment has led to an increase in the number of reported cases of immunotherapy-related endocrinopathies. This study aimed to analyze and compare human leukocyte antigen (HLA) signatures associated with ICI-induced type 1 diabetes (ICI-T1D) and isolated adrenocorticotropic hormone deficiency (ICI-IAD) in patients with both conditions. METHODS: HLA signatures were examined for their frequencies of occurrence in 22 patients with ICI-T1D without concurrent IAD, including 16 patients from nationwide reports (ICI-T1D group) and 14 patients with ICI-IAD without concurrent T1D (ICI-IAD group). The HLA signatures were also compared for their respective frequencies in 11 patients with ICI-T1D and ICI-IAD, including eight from nationwide reports (ICI-T1D/IAD group). RESULTS: In the ICI-T1D group, HLA-DRB1*09:01-DQB1*03:03 and DQA1*03:02, which are in linkage disequilibrium with DRB1*09:01-DQB1*03:03 and DRB1*13:02-DQB1*06:04, were susceptible to ICI-T1D, whereas DRB1*15:02-DQB1*06:01 was protective against ICI-T1D. In the ICI-IAD group, DPB1*09:01, C*12:02-B*52:01, and DRB1*15:02-DRB1*06:01, which are in strong linkage disequilibrium, were associated with susceptibility to ICI-IAD. Moreover, DRB1*15:02-DRB1*06:01 was not detected in the ICI-T1D/IAD group. CONCLUSIONS: This study revealed specific HLA signatures associated with ICI-T1D and ICI-IAD. Moreover, HLA-DRB1*15:02-DRB1*06:01, an ICI-IAD-susceptible HLA haplotype, coincides with the ICI-T1D-protective HLA haplotype, suggesting that the presence of DRB1*15:02-DRB1*06:01 may protect against the co-occurrence of T1D in patients with ICI-IAD.

    DOI: 10.1093/ejendo/lvae081

    PubMed

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  • 周術期の水・電解質管理に難渋した中枢性尿崩症3例

    山川 美早紀, 福永 悦也, 井関 陽平, 長峯 朋子, 長尾 元嗣, 福田 いずみ, 岩部 真人

    日本内分泌学会雑誌   100 ( 1 )   409 - 409   2024.5

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  • 99mTc-MIBIシンチグラフィ陰性の原発性副甲状腺機能亢進症の2症例

    古賀 哲, 矢田 季子, 小澤 秀英, 井上 祥子, 竹内 晴紀, 銭 真臣, 長峯 朋子, 長岡 竜太, 長尾 元嗣, 福田 いずみ, 杉谷 巌, 岩部 真人

    日本内分泌学会雑誌   100 ( 1 )   316 - 316   2024.5

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  • 99mTc-MIBIシンチグラフィ陰性の原発性副甲状腺機能亢進症の2症例

    古賀 哲, 矢田 季子, 小澤 秀英, 井上 祥子, 竹内 晴紀, 銭 真臣, 長峯 朋子, 長岡 竜太, 長尾 元嗣, 福田 いずみ, 杉谷 巌, 岩部 真人

    日本内分泌学会雑誌   100 ( 1 )   316 - 316   2024.5

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Misc.

  • イプラグリフロジン治療による動脈硬化リスクへの影響-SUCRE研究最終報告-

    及川眞一, 長尾元嗣, 谷村(稲垣)恭子, 長峯朋子, 小林俊介, 周東佑樹, 杉原仁

    糖尿病(Web)   66 ( Suppl )   2023

  • 免疫チェックポイント阻害薬によるACTH単独欠損症と特発性ACTH単独欠損症におけるHLAの比較

    大野 万葉, 福田 いずみ, 長尾 元嗣, 富永 敬子, 小林 俊介, 長峯 朋子, 山口 祐司, 稲垣 恭子, 杉原 仁

    日本内分泌学会雑誌   98 ( 1 )   339 - 339   2022.4

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  • 高用量黄体ホルモン療法により続発性副腎皮質機能低下症を来たした2例

    井関 陽平, 長峯 朋子, 高村 悠里亜, 榎本 泰之, 柴山 雅行, 山田 隆, 岡島 史宜, 杉原 仁

    日本内分泌学会雑誌   97 ( 4 )   783 - 783   2021.12

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  • 抗けいれん薬による甲状腺ホルモン低値を示した一例

    高村 悠里亜, 長峯 朋子, 井関 陽平, 榎本 泰之, 柴山 雅行, 岡島 史宜, 杉原 仁

    日本内分泌学会雑誌   97 ( 4 )   800 - 800   2021.12

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  • 内分泌疾患における性差

    長峯 朋子, 福田 いずみ

    糖尿病・内分泌代謝科   53 ( 1 )   105 - 110   2021.7

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    Language:Japanese   Publisher:(有)科学評論社  

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