記述言語：日本語   出版者・発行元：(株)メディカル葵出版  

目的:広義原発開放隅角緑内障(POAG)におけるカルテオロール/ラタノプロスト配合点眼剤(以下、CAR/LAT)単独への変更による1年間の眼圧下降効果を後ろ向きに検討する。対象および方法:プロスタグランジン関連薬(以下、PG)単剤または異種のPG/β遮断薬配合剤(以下、PG/β)単独からの切り替えで、CAR/LATを新規に処方した広義POAG患者のうち、緑内障手術歴のない連続65例を対象とした。変更前と変更1ヵ月後、3ヵ月後、6ヵ月後、12ヵ月後の眼圧をそれぞれ比較した。結果:PGからの変更では、眼圧(平均±標準偏差)は、変更前14.9±3.2mmHgに対して変更12ヵ月後12.8±2.1mmHgで、変更前と比べて変更後のすべての時点で有意な眼圧下降を認めた(p<0.05)。異種のPG/βからの変更では、有意な変化はなかった(p=0.30)。結論:広義POAGにおいて、PG単剤からCAR/LATへの変更では、1年間有意な眼圧下降が得られ、また、異種のPG/β単独からの変更では有意な眼圧変化はない。(著者抄録)

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その他リンク： https://search.jamas.or.jp/default/link?pub_year=2022&ichushi_jid=J01784&link_issn=&doc_id=20220624100023&doc_link_id=%2Fah9atgke%2F2022%2F003906%2F020%2F0830-0834%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fah9atgke%2F2022%2F003906%2F020%2F0830-0834%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Decreased vision and cystoid macular edema (CME) developed in phakic eyes of a patient who underwent laser iridotomy after changing the glaucoma eye drops from carteolol 2% long-acting ophthalmic solution to omidenepag isopropyl 0.002%. CME completely disappeared at approximately 2 months after discontinuation of omidenepag isopropyl in conjunction with the use of bromfenac sodium 0.1%.

DOI： 10.1272/jnms.JNMS.2021_88-520

PubMed

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

PURPOSE: To clarify the intraocular pressure (IOP)-lowering effect of a selective prostanoid EP2 receptor agonist, omidenepag isopropyl (OMDI) during a 24-hour period. PATIENTS AND METHODS: Subjects aged ≥20 years and with diagnosed, untreated primary open-angle glaucoma or ocular hypertension were enrolled. IOP measurements were performed every 4 hours over a 24-hour period using a Goldmann applanation tonometer (GAT) and Icare PRO tonometer (PRO). The baseline 24-hour IOP was measured in untreated subjects. After the baseline measurements, participants were given OMDI 1 drop once daily at night for 4 weeks. At week 4, the IOP measurement was repeated under the same conditions. Diurnal (9 am, 1 pm, 5 pm) and nocturnal (9 pm, 1 am, 5 am) IOP measurements were compared between baseline and treatment with OMDI. Safety measures included adverse events, slit-lamp biomicroscopy, visual acuity, heart rate and blood pressure. RESULTS: Of 27 participants enrolled, 25 patients (20 males and 5 females, average age 52.2 ± 8.5 years) completed the study. In the sitting position, the baseline diurnal and nocturnal mean IOPs (GAT) were 19.1 ± 2.1 mmHg and 18.2 ± 2.6 mmHg, respectively, the diurnal and nocturnal mean IOP reduction from baseline were -2.8 ± 2.6 mmHg (p < 0.0001) and -3.3 ± 2.9 mmHg (p < 0.0001), respectively, mean 24-hour IOP (GAT) was significantly lower with the OMDI treatment (-3.1 ± 2.5 mmHg, p < 0.0001). In the supine position, the baseline nocturnal mean IOP (PRO) was 17.99 ± 2.22 mmHg, and the nocturnal mean IOP reduction from baseline was -1.78 ± 2.37 mmHg (p = 0.0009) after 4 weeks of the treatment. Nine adverse events were observed in 8 patients including mild conjunctival hyperemia (n = 8) and mild iritis (n=1). There were no significant effects on systemic safety. CONCLUSION: Once daily OMDI treatment was able to produce stable 24-hour IOP reduction.

DOI： 10.2147/OPTH.S333042

PubMed

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

We describe the case of a primary open-angle glaucoma patient with re-elevated nocturnal sitting intraocular pressure (IOP) after restarting medical therapy due to a failing bleb. IOP was markedly higher than diurnal IOP during multiple-drug therapy in both eyes, but it did not increase in the left eye with a functional bleb without medical therapy after trabeculectomy with adjuvant mitomycin. However, nocturnal sitting IOP was re-elevated after restarting multiple-drug therapy due to a failing bleb, while diurnal IOP was maintained at a low level.

DOI： 10.1272/jnms.JNMS.2021_88-521

PubMed

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記述言語：日本語   出版者・発行元：日本緑内障学会  

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記述言語：日本語   出版者・発行元：日本緑内障学会  

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記述言語：日本語   出版者・発行元：(公財)日本眼科学会  

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記述言語：日本語   出版者・発行元：日本緑内障学会  

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記述言語：日本語   出版者・発行元：日本緑内障学会  

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