掲載種別：研究論文（学術雑誌）  

DOI： 10.1111/1346-8138.17250

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担当区分：筆頭著者,　責任著者   掲載種別：研究論文（学術雑誌）  

DOI： 10.3390/ph17040519

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担当区分：筆頭著者,　責任著者   掲載種別：研究論文（学術雑誌）  

DOI： 10.1007/s40261-024-01352-4

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担当区分：筆頭著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

BACKGROUND: Upadacitinib is an oral Janus kinase (JAK) 1 inhibitor approved in Japan for moderate-to-severe atopic dermatitis (AD), and it provides a high therapeutic efficacy. OBJECTIVES: We compared the therapeutic effects of upadacitinib on skin rashes of individual anatomical sites, head and neck, upper limbs, lower limbs, and trunk in patients with AD. METHODS: From August 2021 to December 2022, 65 Japanese patients with moderate-to-severe AD (aged ≥ 12 years) were treated with oral once daily upadacitinib 15 mg plus twice daily topical corticosteroids of moderate-to-strongest classes. RESULTS: The eczema area and severity indexes (EASIs) of individual sites decreased significantly at weeks 4, 12, and 24 compared to those at week 0 in parallel to total (whole body) EASI. The achievement rates of EASI 75 at week 24 and of EASI 90 at week 12 of lower limbs were significantly higher than those of trunk. The percent reductions of EASI of lower limbs at weeks 12 and 24 were significantly higher than those of head and neck and of trunk. CONCLUSIONS: Among the four anatomical sites, the treatment responsiveness to upadacitinib in lower limbs appeared the highest, while those in trunk and in head and neck appeared relatively lower.

DOI： 10.1080/09546634.2023.2212095

PubMed

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担当区分：筆頭著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

BACKGROUND: Atopic dermatitis (AD) is a chronic eczematous disease with severe pruritus. Janus kinase (JAK) inhibitors, upadacitinib, baricitinib, and abrocitinib, are systemic treatments for AD. The outcomes of switching from one JAK inhibitor to another have not been examined. OBJECTIVES: We assessed the outcomes of switching from baricitinib 4 mg to upadacitinib 30 mg in Japanese patients with moderate-to-severe AD. METHODS: Twenty patients treated with baricitinib 4 mg, showing insufficient response or adverse events, were switched to treatment with upadacitinib 30 mg. We evaluated total eczema area and severity index (EASI), EASI at head and neck, trunk, upper, or lower limbs, EASI of erythema, edema/papulation, excoriation, or lichenification, and peak pruritus numerical-rating scale (PP-NRS) at baseline (start of baricitinib), weeks 0 (time of switching), and 4 and 12 after switching. RESULTS: Total EASI, EASI at each anatomical site, EASI of each clinical sign, and PP-NRS were markedly reduced at weeks 4 or 12 compared to week 0. Achievement rates of more than 75% or 90% reduction of EASI from baseline significantly improved after switching. CONCLUSIONS: Switching from baricitinib 4 mg to upadacitinib 30 mg effectively improved rash and pruritus.

DOI： 10.1080/09546634.2023.2276043

PubMed

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担当区分：筆頭著者,　責任著者   掲載種別：研究論文（学術雑誌）  

DOI： 10.2147/CCID.S439053

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担当区分：筆頭著者,　最終著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

Atopic dermatitis (AD) is a chronic eczematous disease with various types of rash, erythema, edema/papulation, excoriation, or lichenification. Janus kinase 1 inhibitor upadacitinib is effective for moderate-to-severe AD. We aimed to investigate the therapeutic effects of upadacitinib on each rash type in AD patients in real-world clinical practice. Seventy-two Japanese patients with moderate-to-severe AD were treated with oral upadacitinib 15 mg/day plus topical corticosteroids. The Eczema Area and Severity Index (EASI) scores for erythema, edema/papulation, excoriation, or lichenification on the whole body or on head and neck, upper limbs, lower limbs, or trunk were assessed at weeks 0, 4, and 12 of treatment. The proportions of patients who achieved resolution or at least 75% reduction of EASI from baseline (EASI 75) for individual rash types were calculated at weeks 4 and 12 on the whole body or each anatomical site. The resolution rates for excoriation, erythema, edema/papulation, or lichenification on the whole body were 38.3%, 23.7%, 21.7%, and 8.3% at week 4 and 18.3%, 18.6%, 11.6%, and 13.3% at week 12, respectively. The EASI scores for all rash types significantly decreased at weeks 4 and 12 compared to week 0. The achievement rates of EASI 75 for excoriation, erythema, edema/papulation, or lichenification on the whole body were 67.2%, 66.7%, 49.2%, and 37.7% at week 4 and 57.3%, 65%, 41%, and 41% at week 12, respectively. The achievement rate of EASI 75 for erythema on head and neck at week 4 (45.3%) was lower than that on upper limbs (71%) and on lower limbs (70.8%), and that on head and neck at week 12 (42.2%) was lower than that on lower limbs (69.2%). These results indicate that upadacitinib is effective for all AD rash types, especially for excoriation and erythema, while head-and-neck erythema might be less responsive to upadacitinib.

DOI： 10.1111/1346-8138.16950

PubMed

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

BACKGROUND: Bullous pemphigoid (BP) is an autoimmune subepidermal blistering disease. Dietary habits may modulate the pathogenesis of BP. OBJECTIVES: We evaluated dietary habits in Japanese patients with BP and compared their results to those of age- and sex-matched healthy controls. We also examined the relationship between dietary habits versus IgG anti-BP180NC16A antibody or parameters of BP disease area index (BPDAI); cutaneous blisters/erosions, cutaneous urticaria/erythema, and mucosal blisters/erosions. MATERIALS & METHODS: Dietary habits were assessed by the validated, Brief-type self-administered Diet History Questionnaire. Severity of disease was assessed with BPDAI. RESULTS: Patients with BP showed a lower intake of retinol (vitamin A1) and beverages, and a higher intake of seasoning/spices, compared to controls. The bivariate and multivariable logistic regression analysis showed that BP was associated with a low intake of retinol and beverages. There were no significant correlations between IgG anti-BP180NC16A antibody levels and intake of nutrients/foods. The BPDAI score for cutaneous blisters/erosions significantly positively correlated with intake of carbohydrate and negatively with intake of retinol, vitamin A, animal fat, cholesterol, phosphorus, and vitamin B2. The BPDAI score for cutaneous urticaria/erythema significantly negatively correlated with intake of vitamin A. BP patients with mucosal blisters/erosions had a higher intake of cholesterol, n-6 polyunsaturated fatty acid, and eggs, and lower intake of seasoning/spices, compared to patients without BP. CONCLUSION: The supplementation of vitamin A might have prophylactic and/or therapeutic effects on BP.

DOI： 10.1684/ejd.2023.4527

PubMed

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担当区分：筆頭著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

Upadacitinib, an oral Janus kinase 1 inhibitor approved for treating atopic dermatitis (AD), can cause adverse events such as herpes zoster (HZ) and acne. We aimed to identify background factors predicting the occurrence of HZ and acne during upadacitinib treatment in patients with AD. From August 2021 to December 2022, 112 Japanese patients with moderate-to-severe AD (aged ≥12 years) were treated with upadacitinib 15 mg/day (78 patients) or 30 mg/day (34 patients) plus topical corticosteroids or delgocitinib limited to head and neck for 3-9 months. AD patients with the occurrence of HZ during upadacitinib treatment had higher incidences for history of HZ and of bronchial asthma than those without in the upadacitinib 15 mg, 30 mg, and whole groups. AD patients with occurrence of HZ had higher pretreatment values of lactate dehydrogenase and eczema area and severity index on head and neck compared to those without in the upadacitinib 15 mg and whole groups. Logistic regression analysis revealed that history of HZ was associated with the occurrence of HZ in the upadacitinib 15 mg and whole groups. The proportion of underage patients (<18 years) was higher in patients with occurrence of acne compared to those without in the upadacitinib 30 mg group, but no significant differences were found in the other background factors between the two patient populations. History of HZ may predict the occurrence of HZ during upadacitinib treatment in patients with AD.

DOI： 10.1111/1346-8138.16879

PubMed

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担当区分：筆頭著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1111/1346-8138.16866

PubMed

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担当区分：筆頭著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

Atopic dermatitis (AD) is a chronic inflammatory skin disease with severe itch. The eosinophil-to-lymphocyte ratio (ELR), neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR) are reported to reflect itch or the severity of AD. We examined if these parameters may act as indicators for therapeutic effects of the Janus kinase 1 inhibitor upadacitinib for patients with AD in real-world clinical practice. Between August 2021 and September 2023, 65 Japanese patients (aged ≥ 12 years) with moderate to severe AD were treated with 15 mg/day of oral upadacitinib, plus twice daily topical corticosteroids. Before treatment, the baseline ELR, NLR, MLR, and PLR levels positively correlated with the eczema area and severity index (EASI), while the baseline NLR and PLR levels positively correlated with the peak pruritus-numerical rating scale (PP-NRS). After upadacitinib treatment, ELR and NLR remarkably decreased at week 4 and the reduced levels were maintained until week 24, in parallel with EASI and PP-NRS, while MLR and PLR transiently reduced at week 4, but returned to baseline levels after week 12. The percent reduction of ELR significantly correlated with the percent reductions of EASI and PP-NRS at weeks 4, 12, and 24 of upadacitinib treatment. ELR may act as an indicator for the improvement of clinical signs and itch by upadacitinib treatment in AD.

DOI： 10.3390/jcm12062201

PubMed

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担当区分：筆頭著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

The authors evaluated the efficacy and safety of baricitinib, a Janus kinase 1/2 inhibitor, for atopic dermatitis (AD) in real-world practice. From August 2021 to September 2022, 36 patients aged ≥15 years with moderate to severe AD were treated with oral baricitinib 4 mg/day plus topical corticosteroids. Baricitinib improved clinical indexes; the percent reduction at weeks 4 and 12 was a median of 69.19% and 69.98% for the Eczema Area and Severity Index (EASI), 84.52% and 76.33% for the Atopic Dermatitis Control Tool, and 76.39% and 64.58% for Peak Pruritus Numerical Rating Score, respectively. The achievement rate of EASI 75 was 38.89% and 33.33% at weeks 4 and 12, respectively. The percent reduction of EASI in the head and neck, upper limbs, lower limbs, and trunk was 56.9%, 68.3%, 80.7%, and 62.5% at week 12, respectively, with a significant difference between the head and neck versus the lower limbs. Baricitinib decreased thymus and activation-regulated chemokine, lactate dehydrogenase, and total eosinophil count at week 4. Baseline EASI of the head and neck negatively correlated with percent reduction of EASI at week 4, while baseline EASI of the lower limbs positively correlated with percent reduction of EASI at week 12. Treatment-emergent adverse events included elevation of creatine phosphokinase (11.1%), herpes labialis (5.6%), furuncle (8.3%), and exacerbation of AD (1%), without serious treatment-emergent adverse events. In this real-world study, baricitinib was well tolerated for patients with AD and achieved therapeutic effects comparable to those in clinical trials. High baseline EASI of the lower limbs might predict good treatment response at week 12, while high baseline EASI of the head and neck might predict poor treatment response at week 4 in baricitinib treatment for AD.

DOI： 10.1111/1346-8138.16763

PubMed

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担当区分：筆頭著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

Psoriasis is associated with cardiometabolic and cardiovascular diseases. Biologic therapy targeting tumor necrosis factor (TNF)-α, interleukin (IL)-23, and IL-17 may improve not only psoriasis but also cardiometabolic diseases. We retrospectively evaluated whether biologic therapy improved various indicators of cardiometabolic disease. Between January 2010 and September 2022, 165 patients with psoriasis were treated with biologics targeting TNF-α, IL-17, or IL-23. The patients' body mass index; serum levels of HbA1c, total cholesterol, high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol, triglyceride (TG), and uric acid (UA); and systolic and diastolic blood pressures were recorded at weeks 0, 12, and 52 of the treatment. Baseline psoriasis area and severity index (week 0) positively correlated with TG and UA levels but negatively correlated with HDL-C levels, which increased at week 12 of IFX treatment compared to those at week 0. UA levels decreased at week 12 after ADA treatment compared with week 0. HDL-C levels decreased 52 weeks after IXE treatment. In patients treated with TNF-α inhibitors, HDL-C levels increased at week 12, and UA levels decreased at week 52, compared to week 0. Thus, the results at two different time points (at weeks 12 and 52) were inconsistent. However, the results still indicated that TNF-α inhibitors may improve hyperuricemia and dyslipidemia.

DOI： 10.3390/jcm12051934

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担当区分：筆頭著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

We performed a retrospective and observational study of patients with psoriasis. The aim of this study was to define the laboratory indicators reflecting the treatment response to tumor necrosis factor (TNF)-α inhibitors and the predictors for the treatment response. From January 2010 to June 2022, 28, 15 and 12 patients with psoriasis were treated with infliximab (IFX), adalimumab (ADA) and certolizumab pegol (CZP), respectively. The values of C-reactive protein (CRP), platelet to lymphocyte ratio (PLR), neutrophil to lymphocyte ratio and monocyte to lymphocyte ratio decreased in parallel with psoriasis area and severity index (PASI) at weeks 12 and 52 of treatment. The percentage reduction of the CRP was correlated with that of the PASI at week 52 in all patients and subgroups treated with IFX. The percentage reduction of the PLR was correlated with that of the PASI at week 52 in all patients. Linear multivariate regression analyses revealed that the presence of scalp lesions was associated with a high percentage reduction of the PASI at week 52 in the ADA subgroup. The CRP and PLR might act as biomarkers reflecting the treatment response to TNF-α inhibitors in patients with psoriasis. The presence of scalp lesions might be a predictive factor for a high treatment response to ADA in patients with psoriasis.

DOI： 10.3390/jcm12030974

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担当区分：筆頭著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

We evaluated the efficacy and safety of upadacitinib, janus kinase 1 inhibitor for atopic dermatitis (AD) in real-world practice. From September 2021 to March 2022, 31 patients with moderate-to-severe AD, aged ≥12 years were treated with oral upadacitinib 15 mg/day plus topical corticosteroids. Upadacitinib reduced clinical indexes compared to baseline levels: percent reduction at week 4 and 12 (median) was 73.6% and 85.6% in eczema area and severity index (EASI); 81.3% and 81.3% in AD control tool (ADCT); and 70% and 75% in peak pruritus numerical rating score (PP-NRS), respectively. The achievement rate of EASI 75 was 51.6% and 67.7% at week 4 and 12, respectively. Upadacitinib reduced serum lactate dehydrogenase and total eosinophil count (TEC) at week 4 and 12, and thymus and activation-regulated chemokine and immunoglobulin E at week 4, compared to baseline levels. Percent reduction of TEC was correlated with that of EASI at week 4 and 12. Baseline TEC was positively correlated with the percent reduction of EASI at week 4. Percent reduction of EASI in female patients was higher than that in male patients at week 4 and 12. Linear multivariate regression analyses revealed that high percent reduction of EASI at week 4 or 12 was associated with high baseline TEC or female gender, respectively. There were no serious treatment-emergent adverse events. Adverse events include acne (5%), elevation of creatine phosphokinase (9.7%), herpes zoster (1%), and AD (1%). Upadacitinib plus topical corticosteroids for patients with AD in the real-world practice was well tolerated and gave therapeutic effects comparable with those in previous clinical trials. The ADCT and PP-NRS rapidly reduced at week 4 while EASI gradually reduced until week 12. The TEC might act both as a predictive factor of response at week 4 and as a biomarker reflecting therapeutic effects in upadacitinib treatment for AD.

DOI： 10.1111/1346-8138.16549

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記述言語：日本語   出版者・発行元：金原出版(株)  

＜文献概要＞71歳,女性。X年6月に当院血液内科で骨髄異形成症候群と診断された。同年7月下旬に血液内科に入院し,アザシチジン療法をday 1〜7に施行した。Day 19から右頬部,右示指MP関節背面,左示指PIP関節側面,両下腿後面に軽度圧痛を伴う一部環状の浮腫性紅斑が生じ,両上肢に拡大した。Sweet病を疑い,プレドニゾロン25mg/日,ヨウ化カリウム900mg/日内服により皮疹は速やかに消退した。病理組織では真皮上層から下層に好中球浸潤を認め,Sweet病と診断した。自験例は骨髄異形成症候群に伴うSweet病と考えられるが,アザシチジン療法がSweet病発症の誘因となった可能性がある。一方,アザシチジン療法で骨髄異形成症候群に伴うSweet病の症状が改善している症例も報告されている。

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担当区分：筆頭著者,　責任著者   記述言語：英語  

Darier's disease (DD) is a rare autosomal dominant genodermatosis caused by mutations in the ATP2A2 gene, which encodes for the sarcoendoplasmic reticulum calcium ATPase type 2 isoform (SERCA2). In epidermal keratinocytes, the decrease in SERCA2 inhibits the transportation of desmosomal proteins to the plasma membrane, resulting in acantholysis and dyskeratosis. We present the first case of DD with a novel missense mutation in the ATP2A2 gene and successfully treated with calcipotriol/betamethasone dipropionate two-compound ointment. A 34-year-old Japanese woman presented with erythema and scales on the scalp and clusters of keratotic papules on the neck and groin. Similar symptoms were observed in her father, younger sister, and daughter. Histopathological examination revealed corps ronds in the granular layer and grains in the horny layer of the epidermis and acantholytic lacuna just above the basal layer. She was diagnosed with DD. A novel heterozygous missense mutation, c.616A>C (p.Asn206His), was detected in the ATP2A2 gene in both the patient and her daughter. The patient was treated with calcipotriol/betamethasone dipropionate two-compound ointment, which resulted in improvement of the skin eruption. This two-compound topical ointment may be a promising therapeutic strategy in the treatment for DD.

DOI： 10.2147/CCID.S354694

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記述言語：日本語   出版者・発行元：金原出版(株)  

＜文献概要＞51歳,女性。X年8月,口腔内,両眼球の乾燥が出現した。X+1年3月に唾液腺シンチグラフィで唾液の,シルマー試験で涙液の分泌低下が検出され,抗SS-A抗体および抗SS-B抗体陽性で,当院耳鼻咽喉科にてSjoegren症候群と診断された。X+2年12月,前頭部に脱毛を伴う紅斑が出現し,皮膚生検で真皮網状層のムチン沈着を認め,lupus erythematosus tumidusと診断した。X+3年3月,当科にてヒドロキシクロロキン硫酸塩200mg/日と400mg/日を隔日で内服開始し,同年5月には脱毛が軽減し,7月には紅斑も消退した。自験例はSjoegren症候群にlupus erythematosus tumidusを合併した2例目の報告例である。Lupus erythematosus tumidusの発症とSjoegren症候群あるいは抗SS-A抗体との関連については,今後の症例の蓄積と基礎研究による解明が望まれる。

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記述言語：日本語   出版者・発行元：金原出版(株)  

＜文献概要＞45歳,男性。初診時,左後頭部の,生下時よりある黄赤色小結節の癒合した局面上に,長径2.5cm大のドーム状に隆起し,びらんと痂皮を伴う淡紅色腫瘤を認めた。病理組織像では,表皮内に外方向性に突出する腫瘍細胞の胞巣を認め,腫瘍胞巣は腺管あるいは乳頭腫構造を呈し,真皮まで浸潤していた。腫瘍細胞は断頭分泌を伴う円柱上皮細胞と小型立方形細胞から構成され,核異型性を示した。腫瘍の下床には,毛包脂腺組織とアポクリン腺が増殖していた。脂腺母斑上に生じたsyringocystadenocarcinoma papilliferumと診断した。Syringocystadenocarcinoma papilliferumは極めてまれであるため,臨床・病理組織学的所見,治療法は確立しておらず,今後,症例の蓄積による検討が望まれる。

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その他リンク： https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2021&ichushi_jid=J01266&link_issn=&doc_id=20210422110018&doc_link_id=10.18888%2Fhi.0000002488&url=https%3A%2F%2Fdoi.org%2F10.18888%2Fhi.0000002488&type=%88%E3%8F%91.jp_%83I%81%5B%83%8B%83A%83N%83Z%83X&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

担当区分：筆頭著者   記述言語：英語  

DOI： 10.1111/1346-8138.15622

PubMed

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記述言語：日本語   出版者・発行元：金原出版(株)  

＜文献概要＞65歳,女性。背部,乳房下,臍部,頭皮に紅斑と少数の水疱,上下の歯肉にびらん,硬口蓋に血疱が出現した。組織学的に表皮下水疱を呈し,蛍光抗体直接法で表皮基底膜部にIgG,C3cの線状沈着を認め,1M食塩水剥離皮膚を基質とした蛍光抗体間接法で患者血清IgGが表皮側に反応した。免疫ブロット法ではBP180 NC16aとC末端部の組み換え蛋白に対するIgG抗体が検出された。抗BP180型粘膜類天疱瘡と診断。ミノサイクリン塩酸塩,ニコチン酸アミド内服で皮疹,口腔内病変は軽快した。抗BP180 NC16a抗体と抗C末端抗体陽性のMMP患者では,主として前者が皮疹の発症に,後者が粘膜病変の発症に寄与していると考える。

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その他リンク： https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2021&ichushi_jid=J01266&link_issn=&doc_id=20210126100012&doc_link_id=10.18888%2Fhi.0000002342&url=https%3A%2F%2Fdoi.org%2F10.18888%2Fhi.0000002342&type=%88%E3%8F%91.jp_%83I%81%5B%83%8B%83A%83N%83Z%83X&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

記述言語：日本語   出版者・発行元：金原出版(株)  

＜文献概要＞7歳,女児。躯幹・四肢にそう痒を伴う紅斑,丘疹,痂皮が出現した。膿痂疹性湿疹を疑い,ステロイド外用や内服で治療するも難治性で,1年後に緊満性水疱が出現した。病理組織学的に好中球浸潤を伴う表皮下水疱を呈し,蛍光抗体直接法で基底膜にIgAの線状沈着を認め,1M食塩水剥離皮膚を用いた蛍光抗体間接法で,基底膜表皮側にIgAが陽性であった。小児型linear IgA bullous dermatosis lamina lucida typeと診断した。ジアミノジフェニルスルホン内服で皮疹は消退した。難治性で,そう痒を伴う蕁麻疹様紅斑を診た際には自己免疫性水疱症を考え,病理組織学的検査,蛍光抗体法などの検査を行う必要がある。

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その他リンク： https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2021&ichushi_jid=J01266&link_issn=&doc_id=20210126100015&doc_link_id=10.18888%2Fhi.0000002345&url=https%3A%2F%2Fdoi.org%2F10.18888%2Fhi.0000002345&type=%88%E3%8F%91.jp_%83I%81%5B%83%8B%83A%83N%83Z%83X&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

記述言語：日本語   出版者・発行元：(公社)日本皮膚科学会  

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担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

Purpose: Alopecia areata (AA) is characterized by non-scarring, patchy hair loss caused by autoimmune reactions to anagen hair follicles. The pathogenesis of AA may be affected by the diet. However, the dietary habits of patients with AA have not been precisely examined. Therefore, the aim of this study was to investigate the dietary habits of patients with AA in comparison to those of healthy controls. Patients and Methods: We evaluated the dietary habits of 70 adult Japanese patients with AA using a brief-type self-administered diet history questionnaire and compared them to the habits of age- and sex-matched healthy controls. Results: Japanese patients with AA had a higher body mass index (BMI) and higher intakes of vitamin C and fruit than the controls. Logistic regression analysis showed that AA was associated with BMI. Retinol intake was positively correlated with severity of alopecia tool (SALT) score, and linear regression analysis revealed that retinol intake was a predictor of SALT score. Retinol intake among patients with moderate to severe AA (ie, a SALT score >25) was higher than that in patients with mild AA (a SALT score ≤25). The mean age of AA patients with atopic dermatitis (AD) was lower than that of AA patients without AD; however, there were no differences in nutrient or food intake between these two groups. Logistic regression analysis showed that the comorbidity AD was negatively associated with age. Conclusion: AA was associated with a high BMI, and high retinol intake was a predictor of SALT score. Further studies should be conducted to clarify whether dietary intervention to reduce BMI or limit retinol intake can alter the development or severity of AA.

DOI： 10.2147/CCID.S335440

PubMed

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記述言語：日本語   出版者・発行元：金原出版(株)  

＜文献概要＞6歳,女児。2歳頃より,頭頸部に紅暈を伴う膿疱がみられ,近医を受診した。真菌・細菌培養陰性で,ステロイド薬外用や抗菌薬内服・外用で治療された。皮疹は出没を繰り返すため,精査目的に当科を紹介受診した。ステロイド薬外用で経過観察していたが,皮疹が拡大し,頸部から胸部,臍周囲の地図状の紅斑局面上に弛緩性膿疱が多発した。初診半年後に膿疱部から生検を施行した。組織学的に角層下に好中球性膿疱がみられ,角層下膿疱症と診断した。ステロイド薬,活性型ビタミンD3外用に反応が乏しく,ジアフェニルスルホン25〜75mg/日およびコルヒチン0.5mg/日を内服して皮疹は軽快した。小児角層下膿疱症では,リスク・ベネフィットを考慮して治療を選択すべきである。

J-GLOBAL

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その他リンク： https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2020&ichushi_jid=J01266&link_issn=&doc_id=20201221220034&doc_link_id=10.18888%2Fhi.0000002303&url=https%3A%2F%2Fdoi.org%2F10.18888%2Fhi.0000002303&type=%88%E3%8F%91.jp_%83I%81%5B%83%8B%83A%83N%83Z%83X&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

記述言語：日本語   出版者・発行元：金原出版(株)  

＜文献概要＞症例1:42歳,女性。2007年に四肢の紅斑から皮膚生検し病理組織学的所見より円板状紅斑性狼瘡と診断した。2013年から頭頂部に脱毛斑が生じ,脱毛部の皮膚生検でも同様の診断で,2018年からヒドロキシクロロキン硫酸塩200mg/日と400mg/日を隔日で11ヵ月投与し,脱毛が改善した。症例2:43歳,女性。2000年から頭頂部脱毛があり2017年からフルオシノニドとカルプロニウム塩化物水和物を外用したが脱毛斑が拡大した。2019年に皮膚生検し病理組織学的所見より円板状紅斑性狼瘡と診断した。ヒドロキシクロロキン硫酸塩200mg/日と400mg/日を隔日で4ヵ月投与し,脱毛が改善した。本邦で皮膚エリテマトーデスのヒドロキシクロロキン硫酸塩での脱毛改善例は他に2例報告があるが,いずれの症例も脱毛出現後2年以上経過してヒドロキシクロロキン硫酸塩を導入しても脱毛が改善した。

J-GLOBAL

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記述言語：日本語   出版者・発行元：金原出版(株)  

＜文献概要＞61歳,女性。生下時から右頭頂部に脱毛斑があり,初診2ヵ月前から脱毛斑内に紅色皮膚腫瘍が出現した。当科初診時には,脱毛斑内に紅色隆起性皮膚腫瘍と黒色隆起性皮膚腫瘍が存在した。初回手術で紅色皮膚腫瘍と黒色皮膚腫瘍を切除し,それぞれ有棘細胞癌と毛芽腫であった。2回目の手術で脱毛斑全体を切除し脂腺母斑の病理結果であった。現在,初回手術から術後6ヵ月で有棘細胞癌の再発はない。脂腺母斑から有棘細胞癌を発症することは珍しく,詳細な報告は自験例を含めて邦文および英語文献で32例である。特に,脂腺母斑に有棘細胞癌と毛芽腫を併発した例は,自験例で2例目である。既報32例の臨床病理学的データをまとめたので報告する。

J-GLOBAL

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記述言語：日本語   出版者・発行元：金原出版(株)  

＜文献概要＞41歳,女性。1年前に出現した後頸部皮下腫瘤で当科受診。初診時,後頸部に表面平滑で常色,下床との癒着のない23×15mm大で弾性やや軟の皮下腫瘤を認めた。エコーでは,境界明瞭な嚢胞性腫瘤を認めた。病理組織所見では真皮から皮下脂肪織内に境界明瞭な結節性病変がみられ,免疫染色では,腫瘍細胞の多くがadipophilin陽性,一部CK7,EMA陽性であり,cystic sebaceous tumorと診断した。自験例では内臓悪性腫瘍の合併はなく,Muir-Torre症候群の診断基準を満たさない孤発のまれな例であった。

J-GLOBAL

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その他リンク： https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2020&ichushi_jid=J01266&link_issn=&doc_id=20200602170031&doc_link_id=10.18888%2Fhi.0000001941&url=https%3A%2F%2Fdoi.org%2F10.18888%2Fhi.0000001941&type=%88%E3%8F%91.jp_%83I%81%5B%83%8B%83A%83N%83Z%83X&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

記述言語：日本語   出版者・発行元：(株)郵研社  

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記述言語：日本語   出版者・発行元：(公社)日本皮膚科学会  

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記述言語：日本語   出版者・発行元：(公社)日本皮膚科学会  

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記述言語：日本語   出版者・発行元：(公社)日本皮膚科学会  

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記述言語：日本語   出版者・発行元：(公社)日本皮膚科学会  

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記述言語：日本語   出版者・発行元：(公社)日本皮膚科学会  

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記述言語：日本語   出版者・発行元：(公社)日本皮膚科学会  

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記述言語：日本語   出版者・発行元：(公社)日本皮膚科学会  

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記述言語：日本語   出版者・発行元：(公社)日本皮膚科学会  

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記述言語：日本語   出版者・発行元：(公社)日本皮膚科学会  

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記述言語：日本語   出版者・発行元：(公社)日本皮膚科学会  

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記述言語：日本語   出版者・発行元：(公社)日本皮膚科学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(一社)日本形成外科学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(公社)日本皮膚科学会  

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記述言語：日本語   出版者・発行元：金原出版(株)  

＜文献概要＞71歳,女性。X年6月に当院血液内科で骨髄異形成症候群と診断された。同年7月下旬に血液内科に入院し,アザシチジン療法をday 1～7に施行した。Day 19から右頬部,右示指MP関節背面,左示指PIP関節側面,両下腿後面に軽度圧痛を伴う一部環状の浮腫性紅斑が生じ,両上肢に拡大した。Sweet病を疑い,プレドニゾロン25mg/日,ヨウ化カリウム900mg/日内服により皮疹は速やかに消退した。病理組織では真皮上層から下層に好中球浸潤を認め,Sweet病と診断した。自験例は骨髄異形成症候群に伴うSweet病と考えられるが,アザシチジン療法がSweet病発症の誘因となった可能性がある。一方,アザシチジン療法で骨髄異形成症候群に伴うSweet病の症状が改善している症例も報告されている。

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その他リンク： https://search.jamas.or.jp/default/link?pub_year=2022&ichushi_jid=J01266&link_issn=&doc_id=20220221130019&doc_link_id=10.18888%2Fhi.0000003099&url=https%3A%2F%2Fdoi.org%2F10.18888%2Fhi.0000003099&type=%E5%8C%BB%E6%9B%B8.jp_%E3%82%AA%E3%83%BC%E3%83%AB%E3%82%A2%E3%82%AF%E3%82%BB%E3%82%B9&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

記述言語：日本語   出版者・発行元：(公社)日本皮膚科学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(公社)日本皮膚科学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(公社)日本皮膚科学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(公社)日本皮膚科学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(公社)日本皮膚科学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(公社)日本皮膚科学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(公社)日本皮膚科学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(公社)日本皮膚科学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(公社)日本皮膚科学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(一社)日本神経学会  

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J-GLOBAL

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J-GLOBAL

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開催年月日： 2023年9月 - 2023年10月

会議種別：口頭発表（招待・特別）  

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開催年月日： 2023年8月

会議種別：口頭発表（一般）  

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開催年月日： 2022年8月

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会議種別：口頭発表（招待・特別）  

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会議種別：口頭発表（一般）  

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