Updated on 2025/12/04

写真a

 
Hatori Tsutomu
 
Affiliation
Chibahokusoh Hospital, Department of Diagnostic Pathology, Clinical Associate Professor
Title
Clinical Associate Professor
External link

Papers

  • Insight into the Wnt Pathway in Sporadic Small Bowel Adenocarcinoma. International journal

    Takayoshi Nishimoto, Atsushi Tatsuguchi, Takeshi Yamada, Sho Kuriyama, Aitoshi Hoshimoto, Jun Omori, Naohiko Akimoto, Katya Gudis, Keigo Mitsui, Shu Tanaka, Shunji Fujimori, Tsutomu Hatori, Akira Shimizu, Masanori Atsukawa

    Cancers   17 ( 18 )   2025.9

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND/OBJECTIVES: The Wnt signaling pathway is pivotal in the adenoma-carcinoma sequence; however, its role in small bowel adenocarcinoma (SBA) remains insufficiently characterized. We analyzed the clinicopathological significance of Wnt pathway-related gene mutations and the expression of downstream or associated proteins in SBA. METHODS: Immunohistochemical staining for β-catenin, cyclin D1, c-Myc, E-cadherin, and Wnt5a was performed in 75 primary SBA surgical specimens. Targeted next-generation sequencing was conducted in 48 of these cases. RESULTS: The genomic alterations in the Wnt pathway were identified as APC (14.6%) and CTNNB1 (8.3%), with no overlap between the two mutations. Aberrant (reduced membranous and/or nuclear) expression of β-catenin was observed in 37% of cases. Cyclin D1 and c-Myc were expressed in 60% and 41% of cases, respectively. Aberrant expression of β-catenin and/or Wnt5a was present in 60% of cases and was correlated with cyclin D1 and c-Myc expression. Mutations in APC and CTNNB1 were found in intestinal- and gastrointestinal-type SBAs, but were absent in gastric-type SBA. In intestinal-type SBA, the mutation frequency of APC and CTNNB1 was 39%, closely aligning with the 45% aberrant expression of β-catenin. Aberrant expression of β-catenin and/or Wnt5a, a ligand of the noncanonical Wnt pathway, was detected in 60% of cases and showed a correlation with both cyclin D1 and c-Myc expression. CONCLUSIONS: These findings suggest that both canonical and noncanonical Wnt pathway-related proteins are involved in SBA carcinogenesis and progression. Notably, the canonical Wnt pathway appears to play a predominant role in intestinal-type SBA.

    DOI： 10.3390/cancers17182965

    PubMed

    researchmap

  • Liver metastatic recurrence after curative endoscopic submucosal dissection for slightly submucosal invasive gastric cancer: A case report and literature review. International journal

    Masahiro Niikawa, Teppei Akimoto, Kumiko Kirita, Yuji Yoshida, Tomomi Okubo, Korenobu Hayama, Tsutomu Hatori, Osamu Goto, Shunji Fujimori, Katsuhiko Iwakiri

    DEN open   5 ( 1 )   e70041   2025.4

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    In Japan, differentiated-type early gastric cancer with submucosal invasion <500 µm, tumor diameter <3 cm, no lymphovascular invasion, and negative resection margin are included in pathological curative criteria after endoscopic resection (ER). However, there are a few reports presenting local or metastatic recurrence after ER for the lesions described above. A 72-year-old man was diagnosed with early gastric cancer and underwent endoscopic submucosal dissection (ESD). Pathological diagnosis was well-differentiated tubular adenocarcinoma, 8 × 6 mm, T1b1(SM1; 428 µm below the muscularis mucosae), negative lymphovascular invasion, and negative resection margin, which was included in curative criteria. Eighteen months after ESD, the laboratory studies indicated an increase in carcinoembryonic antigen of 17.6 ng/mL (normal range <5 ng/mL). While endoscopy showed no local recurrence finding, contrast-enhanced computed tomography (CT) showed a metastatic liver tumor in S4. Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging and 18F-fluorodeoxyglucose positron emission tomography/CT revealed metastatic liver tumors in S4, S5, and S8. The liver biopsy specimen showed tubular adenocarcinoma and the findings of immunochemical staining were similar to that of the specimen of prior ESD. Thus, he was diagnosed with multiple liver metastatic recurrences after curative ER. Currently, it has been 3 years and 5 months since ESD and 1 year and 11 months since liver metastatic recurrence, and the patient has survived receiving 5th-line systemic chemotherapy. Here, we report a rare case of liver metastatic recurrence 18 months after curative ESD for early gastric cancer.

    DOI： 10.1002/deo2.70041

    PubMed

    researchmap

  • Relationship Between Immunophenotypes, Genetic Profiles, and Clinicopathologic Characteristics in Small Bowel Adenocarcinoma. International journal

    Aitoshi Hoshimoto, Atsushi Tatsuguchi, Takeshi Yamada, Sho Kuriyama, Ryohei Hamakubo, Takayoshi Nishimoto, Jun Omori, Naohiko Akimoto, Katya Gudis, Keigo Mitsui, Shu Tanaka, Shunji Fujimori, Tsutomu Hatori, Akira Shimizu, Katsuhiko Iwakiri

    The American journal of surgical pathology   48 ( 2 )   127 - 139   2024.2

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    Small bowel adenocarcinoma (SBA) is rare, and scant data exist regarding its molecular and clinicopathologic characteristics. This study aimed to clarify the correlation between immunophenotypes, DNA mismatch repair status, genomic profiling, and clinicopathologic characteristics in patients with SBA. We examined 68 surgical resections from patients with primary SBA for immunohistochemical analyses of CK7, CK20, CD10, CDX2, MUC1, MUC2, MUC4, MUC5AC, and MUC6 expression as well as mismatch repair status. Genomic profiling was performed on 30 cases using targeted next-generation sequencing. Tumor mucin phenotypes were classified as gastric, intestinal, gastrointestinal, or null based on MUC2, MUC5AC, MUC6, and CD10 immunostaining. The expression of these proteins was categorized into 3 classifications according to their relationship to: (1) tumor location: CK7/CK20, MUC4, and MUC6; (2) histologic type: mucinous adenocarcinoma was positive for MUC2 and negative for MUC6; and (3) TNM stage: CD10 was downregulated, whereas MUC1 was upregulated in advanced TNM stages. CDX2 was a specific marker for SBA generally expressed in the small intestine. MUC1 and MUC4 expression was significantly associated with worse prognosis. MUC2 expression correlated with better prognosis, except for mucinous adenocarcinoma. Although the difference was not statistically significant, gastric-type tumors were more frequently located in the duodenum and were absent in the ileum. APC and CTNNB1 mutations were not found in the gastric-type tumors. The SBA immunophenotype correlated with tumor location, biological behavior, and genomic alterations. Our results suggest that the molecular pathway involved in carcinogenesis of gastric-type SBA differs from that of intestinal-type SBA.

    DOI： 10.1097/PAS.0000000000002161

    PubMed

    researchmap

  • Clinical significance of programmed cell death-ligand expression in small bowel adenocarcinoma is determined by the tumor microenvironment. International journal

    Aitoshi Hoshimoto, Atsushi Tatsuguchi, Ryohei Hamakubo, Takayoshi Nishimoto, Jun Omori, Naohiko Akimoto, Shu Tanaka, Shunji Fujimori, Tsutomu Hatori, Akira Shimizu, Katsuhiko Iwakiri

    World journal of gastroenterology   29 ( 40 )   5566 - 5581   2023.10

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: Comprehensive genomic analysis has shown that small bowel adenocarcinoma (SBA) has different genomic profiles from gastric and colorectal cancers. Hence, it is essential to establish chemotherapeutic regimens based on SBA characteristics. The expression of programmed cell death-ligand 1 (PD-L1) and programmed cell death-ligand 2 (PD-L2) in SBA is not fully understood. Anti-PD-L1/PD-1 therapy uses tumor-infiltrating lymphocytes (TILs); therefore, the status of TILs in the tumor microenvironment (TME) may influence their efficacy. The ratio of FoxP3+ to CD8+ T cells has been reported to be useful in predicting the prognosis of digestive system cancers. AIM: To investigate the clinicopathological significance of PD-L1/2 expression according to the status of TILs in SBA tissues. METHODS: We performed immunohistochemical analysis for PD-L1, PD-L2, CD8, FoxP3, and DNA mismatch repair (MMR) proteins using formalin-fixed, paraffin-embedded tissues from 50 patients diagnosed with primary SBA. The immunoreactivities of PD-L1 and PD-L2 were determined separately in tumor cells and tumor-infiltrating immune cells throughout the tumor center and invasive margins, and finally evaluated using the combined positive score (CPS). We assessed CD8+ and FoxP3+ T cells in the intratumoral and tumor-surrounding stroma. Subsequently, we calculated and summed the ratio of FoxP3 to CD8+ T cell counts. Immune-related cell densities were graded as low or high. Immunohistochemical results were compared with clinicopathological factors and patient prognosis. The distribution of cancer-specific survival (CSS) was estimated using the Kaplan-Meier method, and the log-rank test was used to test for significant differences in CSS. A Cox proportional hazard model was also used to assess the effect of tumor variables on CSS. RESULTS: PD-L1 expression was positive in 34% in tumor cells (T-PD-L1) and 54% in tumor-infiltrating immune cells (I-PD-L1) of the cases examined. T-PD-L2 was positive in 34% and I-PD-L2 was positive in 42% of the cases. PD-L1 CPS ≥ 10 and PD-L2 CPS ≥ 10 were observed in 50% and 56% of the cases, respectively. Deficient MMR (dMMR) was 14% of the cases. T-PD-L1, I-PD-L1 and PD-L1 CPS ≥ 10 were all significantly associated with dMMR (P = 0.037, P = 0.009, and P = 0.005, respectively). T-PD-L1, I-PD-L1, and PD-L1 CPS ≥ 10 were all associated with deeper depth of invasion (P = 0.001, P = 0.024, and P = 0.002, respectively). I-PD-L2 expression and PD-L2 CPS ≥ 10 were significantly higher in the differentiated histological type (P = 0.015 and P = 0.030, respectively). The I-PD-L1 and I-PD-L2 levels were significantly associated with better CSS (P = 0.037 and P = 0.015, respectively). CD8-high was significantly associated with less lymph node metastasis (P = 0.047), less distant metastasis (P = 0.024), less peritoneal dissemination (P = 0.034), and earlier TNM stage (P = 0.047). The CD8-high group had better prognosis than the CD8-low group (P = 0.018). FoxP3 expression was not associated with any clinicopathological factors or prognosis. We found that patients with PD-L2 CPS ≥ 10 tended to have worse prognosis in the FoxP3/CD8-low group (P = 0.088). CONCLUSION: The clinicopathological significance of PD-L1/2 expression may differ depending on the TME status. Immune checkpoint inhibitors may improve the prognosis of SBA patients with low FoxP3/CD8 ratio and PD-L2 expression.

    DOI： 10.3748/wjg.v29.i40.5566

    PubMed

    researchmap

  • 悪性腫瘍と鑑別を要した脳結核腫の1例

    小澤 頌, 寺師 直樹, 菅原 崇広, 宮下 稜太, 三上 恵莉花, 清水 理光, 羽鳥 努, 尾関 友博, 清家 正博, 岡野 哲也

    日本結核・非結核性抗酸菌症学会関東支部学会・日本呼吸器学会関東地方会合同学会プログラム・抄録集   184回・256回   25 - 25   2023.9

    　More details

    Language：Japanese   Publisher：日本結核・非結核性抗酸菌症学会関東支部学会・日本呼吸器学会関東地方会  

    researchmap

  • A case of complete resection of prostate stromal sarcoma after neoadjuvant chemotherapy. International journal

    Naoto Hodotsuka, Yasutomo Suzuki, Kyota Suzuki, Yuichiro Honda, Shuma Endo, Eigo Kuribayashi, Kotaro Obayashi, Tadaaki Minowa, Tsutomu Hatori, Yukihiro Kondo

    IJU case reports   6 ( 4 )   239 - 243   2023.7

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    INTRODUCTION: Prostatic stromal sarcoma is an extremely rare malignancy of the prostate with a poor prognosis. CASE PRESENTATION: A 65-year-old man presented with dyschezia, and computed tomography showed a large prostate mass. The diagnosis was prostate stromal sarcoma by transrectal needle biopsy. Magnetic resonance imaging suggested rectal infiltration. The patient underwent 4 courses of neoadjuvant chemotherapy with gemcitabine and docetaxel hydrate followed by total pelvic exenteration. CONCLUSION: No recurrence has occurred at 5 years after the surgery. This is the first report of complete resection in prostate stromal sarcoma after neoadjuvant chemotherapy with gemcitabine and docetaxel hydrate.

    DOI： 10.1002/iju5.12596

    PubMed

    researchmap

  • 内視鏡所見より深達度診断をし得た微小なリンパ球浸潤胃癌の2例

    植村 美咲, 桐田 久美子, 飽本 哲兵, 濱窪 亮平, 木下 舞, 吉田 祐士, 大久保 知美, 葉山 惟信, 長谷川 千花子, 羽鳥 努, 後藤 修, 藤森 俊二, 岩切 勝彦

    Progress of Digestive Endoscopy   103 ( Suppl. )   s118 - s118   2023.6

    　More details

    Language：Japanese   Publisher：(一社)日本消化器内視鏡学会-関東支部  

    researchmap

  • 内視鏡的根治度B後に多発肝転移再発をした胃癌の1例

    新川 将大, 飽本 哲兵, 桐田 久美子, 濱窪 亮平, 木下 舞, 大久保 知美, 吉田 祐士, 葉山 惟信, 平野 孝幸, 後藤 修, 羽鳥 努, 藤森 俊二, 岩切 勝彦

    Progress of Digestive Endoscopy   103 ( Suppl. )   s117 - s117   2023.6

    　More details

    Language：Japanese   Publisher：(一社)日本消化器内視鏡学会-関東支部  

    researchmap

  • Successful immunosuppressant-free treatment of a drug-induced sarcoidosis-like reaction caused by dupilumab. International journal

    Sho Saito, Masamitsu Shimizu, Ryota Miyashita, Tomoyasu Inoue, Atushiro Nagano, Shinobu Kunugi, Tsutomu Hatori, Tetsuya Okano, Masahiro Seike

    Respiratory medicine case reports   44   101883 - 101883   2023

    　More details

    Language：English  

    We present a case of a drug-induced sarcoidosis-like reaction (DISR) in a 34-year-old female patient who had been receiving dupilumab for eosinophilic rhinosinusitis, for seven months. Computerized tomography scans revealed multiple lymphadenopathies, and biopsies performed on the lung and skin lesions showed the presence of non-caseating granulomas. The patient's serum levels of soluble interleukin-2 receptor and angiotensin-converting enzyme were elevated. There were no findings of Mycobacterium spp, or any other bacterial infections. Based on these findings, it was suspected that the sarcoidosis-like reaction observed in this patient was caused by dupilumab. Switching the patient's treatment from dupilumab to mepolizumab improved the DISR.

    DOI： 10.1016/j.rmcr.2023.101883

    PubMed

    researchmap

  • Hemochromatosis and Hepatocellular Carcinoma Secondary to Immunoglobulin G4-Related Disease with Hepatopathy: A Case Report.

    Shintaro Kanaka, Youichi Kawano, Shigeki Yokomuro, Fumihiko Ando, Norio Itokawa, Tsutomu Hatori, Koshi Matsumoto, Yoh Zen, Masao Miyashita, Hiroshi Yoshida

    Journal of Nippon Medical School = Nippon Ika Daigaku zasshi   88 ( 2 )   138 - 144   2021.5

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    Immunoglobulin G4-related disease (IgG4-RD) is a recently characterized illness in which lymphocytes and plasma cells infiltrate various anatomical sites. IgG4-hepatopathy, a manifestation of IgG4-RD, is a broader term covering various patterns of liver injury. The clinical course, including the malignant potential of IgG4-RD, remains unclear. Here we report the first case of secondary hemochromatosis and hepatocellular carcinoma (HCC) developing from IgG4-hepatopathy. A 67-year-old man was admitted to our hospital for treatment of deteriorating glucose tolerance. Blood test results showed hypergammaglobulinemia, especially IgG4. He was readmitted 2 months later with dyspnea due to lung disease and pleural effusion, and elevated transaminase levels. He underwent liver and lung biopsies. IgG4-RD was diagnosed and he was treated with steroid therapy, which improved serum IgG4 levels and imaging abnormalities. A follow-up computed tomography (CT) scan conducted 38 months later revealed a tumor (diameter, 50 mm) in liver segments 7 and 8. The resected specimen revealed HCC and abundant siderosis in the background liver, indicating a diagnosis of hemochromatosis. IgG4-positive cells were scarce, probably because of corticosteroid therapy. In the present case, IgG4-RD was well controlled with prednisolone (PSL) and an immunosuppressive agent, and chronic hepatitis was not severe, even though the patient subsequently developed HCC. However, extensive siderosis consistent with hemochromatosis was unexpectedly noted. These findings suggest that secondary hemochromatosis and HCC developed during IgG4-RD with hepatopathy. We believe this case sheds light on IgG4-RD.

    DOI： 10.1272/jnms.JNMS.2021_88-306

    PubMed

    researchmap

  • 肺癌に対しペムブロリズマブ投与中にirAE大腸炎を発症した1例

    箕輪 真寿美, 恩田 毅, 濱窪 亮平, 肥田 舞, 吉田 祐士, 大久保 知美, 西本 崇良, 糸川 典夫, 辰口 篤志, 藤森 俊二, 羽鳥 努, 岩切 勝彦

    Progress of Digestive Endoscopy   97 ( 1 )   130 - 132   2020.12

    　More details

    Language：Japanese   Publisher：(一社)日本消化器内視鏡学会-関東支部  

    症例は63歳男性で、肺扁平上皮癌に対しペムブロリズマブを計31コース施行し部分奏功を維持していたが、開始から23ヵ月後より下痢を認め、32コース目を中止し入院した。入院時検査所見で軽度炎症反応上昇を認め、下部消化管内視鏡検査および病理組織所見で潰瘍性大腸炎に類似する所見を認めたことから、ペムブロリズマブによる免疫関連副作用(irAE)大腸炎と診断した。プレドニゾロンにより症状は軽快したが、漸減中に誤嚥性肺炎を合併し抗菌薬加療を行った。第70病日に偽膜性腸炎とCMV腸炎を同時合併し、メトロニダゾールおよびガンシクロビルにより症状改善を認めた。第105病日にirAE大腸炎を再燃したが軽症であり、メサラジンによる維持治療で半年経過している。

    researchmap

    Other Link： https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2020&ichushi_jid=J04450&link_issn=&doc_id=20201225120035&doc_link_id=1390005506397623552&url=https%3A%2F%2Fcir.nii.ac.jp%2Fcrid%2F1390005506397623552&type=CiNii&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00003_3.gif

  • Association of vitamin D levels and vitamin D-related gene polymorphisms with liver fibrosis in patients with biopsy-proven nonalcoholic fatty liver disease. International journal

    Taeang Arai, Masanori Atsukawa, Akihito Tsubota, Mai Koeda, Yuji Yoshida, Tomomi Okubo, Ai Nakagawa, Norio Itokawa, Chisa Kondo, Katsuhisa Nakatsuka, Takushi Masu, Keizo Kato, Noritomo Shimada, Tsutomu Hatori, Naoya Emoto, Masayoshi Kage, Katsuhiko Iwakiri

    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver   51 ( 7 )   1036 - 1042   2019.7

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: Vitamin D has promising anti-proliferative and anti-fibrotic properties, but its clinical utility in nonalcoholic fatty liver disease (NAFLD) is unclear. AIMS: This study aimed to clarify the association between vitamin D levels, single nucleotide polymorphisms (SNPs) in vitamin D-related genes, and the histopathological severity of disease in patients with biopsy-proven NAFLD. METHODS: SNPs in CYP2R1, DHCR7, vitamin D binding protein (GC), CYP27B1, and vitamin D receptor (VDR) were determined for 229 consecutive patients with biopsy-proven NAFLD. RESULTS: In this study, vitamin D deficiency defined as 25-hydroxyvitamin-D3 levels of ≤20 ng/mL was found in 151 patients (65.9%). Multivariate analysis revealed that cold season, advanced fibrosis, and CYP2R1 rs1993116 genotype non-AA were independent factors significantly associated with vitamin D deficiency. Old age (p = 5.05 × 10-8), high body mass index (p = 2.13 × 10-2), low total-cholesterol (p = 1.46 × 10-4), low serum vitamin D level (p = 7.34 × 10-3), and VDR rs1544410 genotype CC (p = 9.15 × 10-3) were independent factors associated with advanced liver fibrosis. CONCLUSION: Serum 25-hydroxyvitamin-D3 levels and the VDR gene SNP were significantly and independently associated with the severity of liver fibrosis in patients with biopsy-proven NAFLD.

    DOI： 10.1016/j.dld.2018.12.022

    PubMed

    researchmap

  • Colonic stent-induced mechanical compression may suppress cancer cell proliferation in malignant large bowel obstruction. International journal

    Akihisa Matsuda, Masao Miyashita, Satoshi Matsumoto, Nobuyuki Sakurazawa, Youichi Kawano, Kazuya Yamahatsu, Kumiko Sekiguchi, Marina Yamada, Tsutomu Hatori, Hiroshi Yoshida

    Surgical endoscopy   33 ( 4 )   1290 - 1297   2019.4

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: The short-term safety and efficacy of insertion of a self-expandable metallic colonic stent (SEMS) followed by elective surgery, "bridge to surgery (BTS)", for malignant large bowel obstruction (MLBO) have been well described; however, the influence on long-term oncological outcomes is unclear. The aim of this study was to evaluate changes in oncological characteristics in colorectal cancer (CRC) tissues after SEMS insertion, focusing on growth factors, cell cycle and apoptosis. METHODS: From January 2013 to September 2014, a total of 25 patients with MLBO who underwent BTS at our single institution were retrospectively included. Paired CRC tissue samples before (endoscopic biopsy) and after SEMS insertion (surgically resected) were collected from each patient. EGFR, VEGF, Ki-67, p27kip1 and TUNEL expression were determined by immunohistochemistry. RESULTS: No clinical or subclinical perforations evaluated by mechanical ulceration pathologically were observed. Epithelial exfoliation, tumour necrosis, infiltration of inflammatory cells and fibrosis were observed in SEMS-inserted surgically-resected specimens. Overall, 84% (21/25) and 60% (15/25) of patients exhibited no change or a decrease in staining category, respectively, for EGFR and VEGF expression after SEMS insertion. A significant decrease in Ki-67 expression was observed in surgically-resected specimens compared with endoscopic biopsy specimens (P < 0.01). The upstream cell cycle inhibitor, p27kip1, was significantly increased after SEMS insertion (P = 0.049). CONCLUSIONS: Although the long-term safety of BTS should be determined in a future clinical trial, mechanical compression by SEMS may suppress cancer cell proliferation and this result could provide some insights into the issue.

    DOI： 10.1007/s00464-018-6411-x

    PubMed

    researchmap

  • Factors influencing subclinical atherosclerosis in patients with biopsy-proven nonalcoholic fatty liver disease. International journal

    Taeang Arai, Masanori Atsukawa, Akihito Tsubota, Tadamichi Kawano, Mai Koeda, Yuji Yoshida, Tomohide Tanabe, Tomomi Okubo, Korenobu Hayama, Ai Iwashita, Norio Itokawa, Chisa Kondo, Keiko Kaneko, Chiaki Kawamoto, Tsutomu Hatori, Naoya Emoto, Etsuko Iio, Yasuhito Tanaka, Katsuhiko Iwakiri

    PloS one   14 ( 11 )   e0224184   2019

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    Although the presence of nonalcoholic fatty liver disease (NAFLD) is known to be related to subclinical atherosclerosis, the relationship between the severity of NAFLD and subclinical atherosclerosis is not clear. This study aimed to clarify the factors related to subclinical arteriosclerosis, including the histopathological severity of the disease and PNPLA3 gene polymorphisms, in NAFLD patients. We measured brachial-ankle pulse wave velocity (baPWV) as an index of arterial stiffness in 153 biopsy-proven NAFLD patients. The baPWV values were significantly higher in the advanced fibrosis group than in the less advanced group (median, 1679 cm/s vs 1489 cm/s; p = 5.49×10-4). Multiple logistic regression analysis revealed that older age (≥55 years) (p = 8.57×10-3; OR = 3.03), hypertension (p = 1.05×10-3; OR = 3.46), and advanced fibrosis (p = 9.22×10-3; OR = 2.94) were independently linked to baPWV ≥1600 cm/s. NAFLD patients were categorized into low-risk group (number of risk factors = 0), intermediate-risk group (= 1), and high-risk group (≥2) based on their risk factors, including older age, hypertension, and biopsy-confirmed advanced fibrosis. The prevalence of baPWV ≥1600 cm/s was 7.1% (3/42) in the low-risk group, 30.8% (12/39) in the intermediate-risk group, and 63.9% (46/72) in the high-risk group. Non-invasive liver fibrosis markers and scores, including the FIB-4 index, NAFLD fibrosis score, hyaluronic acid, Wisteria floribunda agglutinin positive Mac-2-binding protein, and type IV collagen 7s, were feasible substitutes for invasive liver biopsy. Older age, hypertension, and advanced fibrosis are independently related to arterial stiffness, and a combination of these three factors may predict risk of arteriosclerosis in NAFLD patients.

    DOI： 10.1371/journal.pone.0224184

    PubMed

    researchmap

  • Serum Wisteria floribunda agglutinin-positive Mac-2 binding protein more reliably distinguishes liver fibrosis stages in non-alcoholic fatty liver disease than serum Mac-2 binding protein. International journal

    Masanori Atsukawa, Akihito Tsubota, Tomomi Okubo, Taeang Arai, Ai Nakagawa, Norio Itokawa, Chisa Kondo, Keizo Kato, Tsutomu Hatori, Hiroshi Hano, Tsunekazu Oikawa, Naoya Emoto, Masanori Abe, Masayoshi Kage, Katsuhiko Iwakiri

    Hepatology research : the official journal of the Japan Society of Hepatology   48 ( 6 )   424 - 432   2018.5

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    AIM: Serum Mac-2 binding protein (M2BP) and Wisteria floribunda agglutinin-positive Mac-2 binding protein (WFA+ -M2BP) are used to estimate the liver fibrosis stage in chronic liver diseases. However, few head-to-head studies have been carried out to compare the two biomarkers in non-alcoholic fatty liver disease (NAFLD). METHODS: Serum M2BP and WFA+ -M2BP levels were compared against clinical characteristics and liver histological manifestations in the same samples collected from 213 biopsy-proven NAFLD patients. RESULTS: Median levels (range) of M2BP and WFA+ -M2BP were 1.58 (0.70-7.75) pg/mL and 0.85 (0.22-11.32) cut-off index (COI), respectively. Fibrosis stages 1, 2, 3, and 4 were determined in 136, 37, 17, and 23 patients, respectively. Median levels of both biomarkers increased stepwise with fibrosis progression. The M2BP and WFA+ -M2BP levels showed a significant positive correlation (r = 0.643, P = 2.91 × 10-26 ), but a marked discrepancy between both biomarkers was noted in five stage 4 and three stage 1 patients, who had high WFA+ -M2BP but relatively low M2BP levels. Most of these outliers had findings suggestive of more advanced fibrosis. For diagnosing any fibrosis severity, WFA+ -M2BP had greater area under the receiver operating characteristic curve (AUC) and predictive accuracy than M2BP. Among eight fibrosis markers/indices, WFA+ -M2BP yielded the second highest AUC (0.832) and the highest predictive accuracy (82.2%) to diagnose cirrhosis. In addition, WFA+ -M2BP showed the second highest predictive accuracy to diagnose severe fibrosis (78.4%) and significant fibrosis (76.1%). CONCLUSION: This head-to-head comparison suggests that WFA+ -M2BP is superior to M2BP for distinguishing liver fibrosis stages in NAFLD patients. A marked discrepancy between the two biomarkers may be indicative of advanced NAFLD (UMIN000023286).

    DOI： 10.1111/hepr.13046

    PubMed

    researchmap

  • An 8-Year-Old Girl with Autoimmune Hepatitis Following Aplastic Anemia.

    Ayako Nishigori, Tsutomu Hatori, Takeshi Asano

    Journal of Nippon Medical School = Nippon Ika Daigaku zasshi   85 ( 4 )   241 - 244   2018

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    We herein report a case of severe aplastic anemia diagnosed in an 8-year-old girl with a previous diagnosis of autoimmune hepatitis. We found significantly increased CD8+ and CD68+ cell numbers in her bone marrow, which can induce severe organ damage, refractory to immunosuppressive therapy.

    DOI： 10.1272/jnms.JNMS.2018_85-38

    PubMed

    researchmap

  • Localized pulmonary crystal-storing histiocytosis complicating pulmonary mucosa-associated lymphoid tissue lymphoma presenting with multiple mass lesions. International journal

    Nariaki Kokuho, Yasuhiro Terasaki, Shinobu Kunugi, Naomi Onda, Hirokazu Urushiyama, Mika Terasaki, Mitsunori Hino, Akihiko Gemma, Tsutomu Hatori, Akira Shimizu

    Human pathology   65   180 - 186   2017.7

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    Crystal-storing histiocytosis (CSH) is an uncommon finding in lymphoplasmacytic disorders that presents histiocytes with abnormal intralysosomal accumulations of immunoglobulin light chains as crystals of unknown etiology. A 38-year-old woman with antiphospholipid syndrome had a surgical lung biopsy because of multiple lung mass lesions. In a right middle lobe lesion, lymphoplasmacytic cells had a monocytoid appearance, destructive lymphoepithelial lesions, and positive immunoglobulin heavy chain (IGH) gene rearrangements. A right upper lobe lesion manifested proliferating rounded histiocytes with abundant, deeply eosinophilic cytoplasm and negative IGH gene rearrangements. Electron microscopy and mass spectrometry revealed a case of pulmonary CSH: abnormal proliferation of the immunoglobulin κ chain of a variable region that may be crystallized within plasma cells and histiocytes. We report a rare case of localized pulmonary CSH complicating pulmonary mucosa-associated lymphoid tissue lymphoma with multiple mass lesions. We demonstrate advances in the understanding of the pathogenesis of CSH by various analyses of these lesions.

    DOI： 10.1016/j.humpath.2016.10.028

    PubMed

    researchmap

  • Laparoscopic Excision of a Uterine Adenomatoid Tumor and a Coexisting Ovarian Teratoma: A Case Report and Literature Review.

    Tomohiko Matsuhashi, Ryoko Matsui, Chikako Hasegawa, Tsutomu Hatori, Seiryu Kamoi, Toshiyuki Takeshita

    Journal of Nippon Medical School = Nippon Ika Daigaku zasshi   84 ( 3 )   139 - 143   2017

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    Adenomatoid tumors (ATs) are rare, benign neoplasms occurring mainly in reproductive organs such as the uterus, ovaries, fallopian tubes, and testes. Uterine adenomatoid tumors (UATs) are generally incidentally diagnosed during histopathological examination of excisional biopsies performed for other indications, most commonly uterine leiomyomas. We herein present a 38-year-old woman who underwent laparoscopic excision of a uterine leiomyoma and a right ovarian teratoma. Microscopic examination of the excisional biopsy revealed that the enucleated uterine tumor was composed of proliferating glandular tissue covered with single-layered cells that were surrounded by proliferating smooth muscle cells, corresponding exactly to the features of UATs. The excised ovarian cyst was confirmed to be a typical mature cystic teratoma. According to these histopathological findings, the patient was finally diagnosed with a UAT and coexisting teratoma. No recurrence was detected up to 6 months after excision. To the best of our knowledge, this is the eighth case report on laparoscopically enucleated UATs. Although recurrence risk may be low in UATs, further case reports are necessary to elucidate the safety and validity of laparoscopic excision for UATs.

    DOI： 10.1272/jnms.84.139

    PubMed

    researchmap

▼display all

Misc.

  • 多発肺結節が子宮筋腫から転移した良悪性判定困難な平滑筋腫瘍と考えられた1例

    計良 怜, 吉野 直之, 羽鳥 努, 臼田 実男

    肺癌   65 ( 3 )   232 - 232   2025.6

    　More details

    Language：Japanese   Publisher：(NPO)日本肺癌学会  

    researchmap

  • 経気管支肺生検が診断に有用であったトラスツズマブデルクステカンによる薬剤性肺障害の一例

    山口 玲, 加藤 泰裕, 倉持 絵梨, 新分 薫子, 青山 純一, 羽鳥 努, 功刀 しのぶ, 清家 正博, 岡野 哲也

    気管支学   47 ( Suppl. )   S249 - S249   2025.5

    　More details

    Language：Japanese   Publisher：(一社)日本呼吸器内視鏡学会  

    researchmap

  • 術後12年経過後に再発をきたしたセミノーマの1例

    佐藤 悠衣, 高橋 信行, 三枝 順子, 京本 晃典, 京本 絢美, 田中 萌, 笹谷 昌司, 長谷川 千花子, 平野 孝幸, 羽鳥 努

    日本臨床細胞学会雑誌   63 ( Suppl.1 )   328 - 328   2024.5

    　More details

    Language：Japanese   Publisher：(公社)日本臨床細胞学会  

    researchmap

  • 細胞診にて腹膜播種経由の転移が考えられた膀胱癌胃転移の一例

    田中 萌, 京本 絢美, 京本 晃典, 三枝 順子, 笹谷 昌司, 高橋 信行, 佐藤 悠衣, 長谷川 千花子, 平野 孝幸, 羽鳥 努

    日本臨床細胞学会雑誌   63 ( Suppl.1 )   300 - 300   2024.5

    　More details

    Language：Japanese   Publisher：(公社)日本臨床細胞学会  

    researchmap

  • 腹腔鏡で安全に切除し得た嚢胞性GISTの1例

    笠谷 峻, 保田 智彦, 新井 洋紀, 柿沼 大輔, 中村 慶春, 吉田 寛, 長谷川 千花子, 羽鳥 努

    日本外科系連合学会誌   49 ( 3 )   297 - 297   2024.5

    　More details

    Language：Japanese   Publisher：日本外科系連合学会  

    researchmap

  • 口腔内メトトレキサート関連リンパ増殖性疾患の一例

    高橋 信行, 三枝 順子, 京本 晃典, 笹谷 昌司, 京本 絢美, 田中 萌, 佐藤 悠衣, 長谷川 千花子, 平野 孝幸, 羽鳥 努

    日本臨床細胞学会雑誌   63 ( Suppl.1 )   280 - 280   2024.5

    　More details

    Language：Japanese   Publisher：(公社)日本臨床細胞学会  

    researchmap

  • 気管支鏡検査が診断の一助になり得た家族性地中海熱の1例

    菅原 崇広, 清水 理光, 鄒 奮飛, 三上 恵莉花, 加藤 泰裕, 羽鳥 努, 清家 正博, 岡野 哲也

    気管支学   46 ( Suppl. )   S326 - S326   2024.5

    　More details

    Language：Japanese   Publisher：(一社)日本呼吸器内視鏡学会  

    researchmap

  • 肺胎盤様奇怪変貌症の一例

    長谷川 千花子, 平野 孝幸, 京本 晃典, 三枝 順子, 高橋 聡, 岡野 哲也, 井上 達也, 平井 恭二, 羽鳥 努

    日本病理学会会誌   113 ( 1 )   365 - 365   2024.2

    　More details

    Language：Japanese   Publisher：(一社)日本病理学会  

    researchmap

  • 子宮体部原発のびまん性大細胞型B細胞リンパ腫の一例

    田中 萌, 高橋 信行, 京本 絢美, 佐藤 悠衣, 京本 晃典, 三枝 順子, 笹谷 昌司, 平野 孝幸, 長谷川 千花子, 羽鳥 努, 鴨井 青龍

    日本臨床細胞学会雑誌   62 ( Suppl.2 )   526 - 526   2023.10

    　More details

    Language：Japanese   Publisher：(公社)日本臨床細胞学会  

    researchmap

  • 悪性腫瘍と鑑別を要した脳結核腫の1例

    小澤 頌, 寺師 直樹, 菅原 崇広, 宮下 稜太, 三上 恵莉花, 清水 理光, 羽鳥 努, 尾関 友博, 清家 正博, 岡野 哲也

    日本結核・非結核性抗酸菌症学会関東支部学会・日本呼吸器学会関東地方会合同学会プログラム・抄録集   184回・256回   25 - 25   2023.9

    　More details

    Language：Japanese   Publisher：日本結核・非結核性抗酸菌症学会関東支部学会・日本呼吸器学会関東地方会  

    researchmap

  • 内視鏡的根治度B後に多発肝転移再発をした胃癌の1例

    新川 将大, 飽本 哲兵, 桐田 久美子, 濱窪 亮平, 木下 舞, 大久保 知美, 吉田 祐士, 葉山 惟信, 平野 孝幸, 後藤 修, 羽鳥 努, 藤森 俊二, 岩切 勝彦

    Progress of Digestive Endoscopy   103 ( Suppl. )   s117 - s117   2023.6

    　More details

    Language：Japanese   Publisher：(一社)日本消化器内視鏡学会-関東支部  

    researchmap

  • 術後10年目に同側乳房内に発生した腫瘍に対し針生検を施行するも診断困難であった紡錘細胞癌の一例

    関 奈紀, 飯田 信也, 米戸 敏彦, 柳原 恵子, 蒔田 益次郎, 羽鳥 努, 伊藤 良則, 武井 寛幸

    日本乳癌学会総会プログラム抄録集   31回   244 - 244   2023.6

    　More details

    Language：Japanese   Publisher：(一社)日本乳癌学会  

    researchmap

  • 内視鏡所見より深達度診断をし得た微小なリンパ球浸潤胃癌の2例

    植村 美咲, 桐田 久美子, 飽本 哲兵, 濱窪 亮平, 木下 舞, 吉田 祐士, 大久保 知美, 葉山 惟信, 長谷川 千花子, 羽鳥 努, 後藤 修, 藤森 俊二, 岩切 勝彦

    Progress of Digestive Endoscopy   103 ( Suppl. )   s118 - s118   2023.6

    　More details

    Language：Japanese   Publisher：(一社)日本消化器内視鏡学会-関東支部  

    researchmap

  • 乳腺原発印環細胞癌の1例

    佐藤 悠衣, 高橋 信行, 三枝 順子, 京本 晃典, 京本 絢美, 田中 萌, 笹谷 昌司, 長谷川 千花子, 平野 孝幸, 羽鳥 努

    日本臨床細胞学会雑誌   62 ( Suppl.1 )   262 - 262   2023.5

    　More details

    Language：Japanese   Publisher：(公社)日本臨床細胞学会  

    researchmap

  • 子宮体部脱分化癌の1例

    高橋 信行, 三枝 順子, 京本 晃典, 笹谷 昌司, 京本 絢美, 田中 萌, 佐藤 悠衣, 長谷川 千花子, 平野 孝幸, 羽鳥 努

    日本臨床細胞学会雑誌   62 ( Suppl.1 )   275 - 275   2023.5

    　More details

    Language：Japanese   Publisher：(公社)日本臨床細胞学会  

    researchmap

  • デュピルマブによるサルコイドーシス様反応が疑われた1例

    井上 智康, 永野 惇浩, 齊藤 翔, 宮下 稜太, 高橋 聡, 小齊平 聖治, 岡野 哲也, 功刀 しのぶ, 羽鳥 努, 久保田 馨, 清家 正博, 弦間 昭彦

    気管支学   44 ( 5 )   397 - 397   2022.9

    　More details

    Language：Japanese   Publisher：(NPO)日本呼吸器内視鏡学会  

    researchmap

  • 子宮体部原発異所性癌肉腫の1例

    高橋 信行, 京本 絢美, 大峯 広貴, 三枝 順子, 京本 晃典, 笹谷 昌司, 田中 萌, 長谷川 千花子, 平野 孝幸, 羽鳥 努

    日本臨床細胞学会雑誌   60 ( Suppl.1 )   255 - 255   2021.5

    　More details

    Language：Japanese   Publisher：(公社)日本臨床細胞学会  

    researchmap

  • 乳腺神経内分泌癌術後15年で肺病変が出現した一例

    田中 萌, 京本 晃典, 大峯 広貴, 三枝 順子, 笹谷 昌司, 京本 絢美, 高橋 信行, 長谷川 千花子, 平野 孝幸, 羽鳥 努

    日本臨床細胞学会雑誌   60 ( Suppl.1 )   225 - 225   2021.5

    　More details

    Language：Japanese   Publisher：(公社)日本臨床細胞学会  

    researchmap

  • Abemaciclibによる薬剤肺障害に対して気管支鏡検査を施行した一例

    三宅 絵里佳, 林 宏紀, 宮寺 恵希, 高橋 聡, 小齊平 聖治, 岡野 哲也, 功刀 しのぶ, 羽鳥 努, 飯田 信也, 清家 正博, 弦間 昭彦

    日本結核・非結核性抗酸菌症学会関東支部学会・日本呼吸器学会関東地方会合同学会プログラム・抄録集   179回・243回   21 - 21   2021.2

    　More details

    Language：Japanese   Publisher：日本結核・非結核性抗酸菌症学会関東支部学会・日本呼吸器学会関東地方会  

    researchmap

  • 初回手術後4ヵ月間に2回の胸壁再発、肺、腋窩および対側肺門部リンパ節転移が出現した乳腺血管肉腫の1例

    関 奈紀, 飯田 信也, 羽鳥 努, 鈴木 えりか, 関口 久美子, 武井 寛幸

    日本臨床外科学会雑誌   81 ( 増刊 )   485 - 485   2020.10

    　More details

    Language：Japanese   Publisher：日本臨床外科学会  

    researchmap

  • 前立腺癌に対するビカルタミド単独療法で治療抵抗性間質性肺炎を呈した一例

    齊藤 理帆, 岡崎 大武, 平野 孝幸, 小林 宣明, 白壁 章宏, 柴田 祐作, 合田 浩紀, 羽鳥 努, 淺井 邦也, 清水 渉

    日本集中治療医学会雑誌   27 ( Suppl. )   635 - 635   2020.9

    　More details

    Language：Japanese   Publisher：(一社)日本集中治療医学会  

    researchmap

  • 広範囲な播種をともないglioblastomaと診断された若年Diffuse leptomeningeal glioneuronal tumorの一例

    大村 朋子, 白金 一貴, 馬場 栄一, 梅岡 克哉, 羽鳥 努, 森田 明夫

    Brain Tumor Pathology   37 ( Suppl. )   122 - 122   2020.8

    　More details

    Language：Japanese   Publisher：日本脳腫瘍病理学会  

    researchmap

  • 肺扁平上皮癌に対してペムブロリズマブ投与中にirAE大腸炎を発症した1例

    箕輪 真寿美, 恩田 毅, 濱窪 亮平, 肥田 舞, 吉田 祐士, 大久保 知美, 西本 崇良, 糸川 典夫, 藤森 俊二, 羽鳥 努, 岩切 勝彦

    Progress of Digestive Endoscopy   97 ( Suppl. )   s111 - s111   2020.5

    　More details

    Language：Japanese   Publisher：(一社)日本消化器内視鏡学会-関東支部  

    researchmap

  • 乳癌術後内分泌療法としてのタモキシフェン投与中に高エストラジオール血症をきたした1例

    飯田 信也, 鈴木 えりか, 羽鳥 努, 武井 寛幸

    日本臨床外科学会雑誌   80 ( 増刊 )   747 - 747   2019.10

    　More details

    Language：Japanese   Publisher：日本臨床外科学会  

    researchmap

  • 黄疸と全身性の結節性黄色腫を契機に診断された原発性胆汁性胆管炎の一例

    肥田 舞, 糸川 典夫, 厚川 正則, 藤森 俊二, 羽鳥 努, 岩切 勝彦

    日本消化器病学会関東支部例会プログラム・抄録集   355回   44 - 44   2019.7

    　More details

    Language：Japanese   Publisher：日本消化器病学会-関東支部  

    researchmap

  • 気管支に発生した扁平上皮腺上皮混合型乳頭腫の一例

    大峯 広貴, 清水 秀樹, 長谷川 千花子, 平野 孝幸, 三枝 順子, 京本 晃典, 笹谷 昌司, 京本 絢美, 羽鳥 努

    日本臨床細胞学会雑誌   58 ( Suppl.1 )   337 - 337   2019.5

    　More details

    Language：Japanese   Publisher：(公社)日本臨床細胞学会  

    researchmap

  • 脳室内に発生したgiant cell glioblastomaの一例

    大村 朋子, 梅岡 克哉, 山田 敏雅, 足立 好司, 水成 隆之, 羽鳥 努, 森田 明夫

    Brain Tumor Pathology   35 ( Suppl. )   188 - 188   2018.9

    　More details

    Language：Japanese   Publisher：日本脳腫瘍病理学会  

    researchmap

  • 乳癌センチネルリンパ節マクロ転移陽性かつZ0011条件適合症例に対する腋窩郭清省略の妥当性の検証

    飯田 信也, 鈴木 えりか, 関口 久美子, 羽鳥 努, 宮下 正夫, 武井 寛幸

    日本乳癌学会総会プログラム抄録集   26回   681 - 681   2018.5

    　More details

    Language：Japanese   Publisher：(一社)日本乳癌学会  

    researchmap

  • 脳腫瘍圧挫標本における髄膜腫の細胞像

    清水 秀樹, 佐藤 春明, 三枝 順子, 京本 晃典, 笹谷 昌司, 京本 絢美, 大峯 広貴, 平野 孝幸, 長谷川 千花子, 羽鳥 努

    日本臨床細胞学会雑誌   57 ( Suppl.1 )   262 - 262   2018.4

    　More details

    Language：Japanese   Publisher：(公社)日本臨床細胞学会  

    researchmap

  • 子宮頸部Large cell neuroendocrine carcinomaとMucinous adenocarcinoma intestinal typeが合併した一例

    大峯 広貴, 笹谷 昌司, 長谷川 千花子, 平野 孝幸, 佐藤 春明, 清水 秀樹, 三枝 順子, 京本 晃典, 京本 絢美, 羽鳥 努, 鴨井 青龍, 山田 隆, 中西 一歩, 松橋 智彦

    日本臨床細胞学会雑誌   56 ( Suppl.2 )   808 - 808   2017.10

    　More details

    Language：Japanese   Publisher：(公社)日本臨床細胞学会  

    researchmap

  • 脳腫瘍の診断目的で行われた脳生検で血管中心性炎症細胞浸潤を認め、中枢神経血管炎が疑われた62歳男性例

    戸田 諭補, 小澤 明子, 江畑 琢矢, 外間 裕之, 大村 朋子, 羽鳥 努, 山崎 峰雄, 木村 和美

    臨床神経学   57 ( 10 )   631 - 631   2017.10

    　More details

    Language：Japanese   Publisher：(一社)日本神経学会  

    researchmap

  • 脳腫瘍における細胞診の有用性 髄膜腫の細胞診

    清水 秀樹, 羽鳥 努, 佐藤 春明

    日本臨床細胞学会雑誌   56 ( Suppl.2 )   616 - 616   2017.10

    　More details

    Language：Japanese   Publisher：(公社)日本臨床細胞学会  

    researchmap

  • 本邦のNAFLD症例の病態にvitamin D代謝関連SNPsの与える影響

    新井 泰央, 厚川 正則, 吉田 祐士, 大久保 知美, 岩下 愛, 糸川 典夫, 近藤 千紗, 羽鳥 努, 加藤 慶三, 島田 紀朋, 坪田 昭人, 岩切 勝彦

    肝臓   58 ( Suppl.2 )   A636 - A636   2017.9

    　More details

    Language：Japanese   Publisher：(一社)日本肝臓学会  

    researchmap

  • 乳癌腋窩リンパ節転移(N因子)の術前診断(画像診断ならびに細胞診)の精度の検討

    飯田 信也, 柳原 恵子, 栗田 智子, 中井 麻木, 鈴木 えりか, 関口 久美子, 羽鳥 努, 宮下 正夫, 武井 寛幸

    日本乳癌学会総会プログラム抄録集   25回   497 - 497   2017.7

    　More details

    Language：Japanese   Publisher：(一社)日本乳癌学会  

    researchmap

  • アファチニブ投与中に小細胞肺癌に形質転換したEGFR遺伝子変異陽性非小細胞肺癌の1例

    本橋 典久, 小齊平 聖治, 内藤 智之, 二島 駿一, 加藤 泰裕, 田中 庸介, 日野 光紀, 羽鳥 努, 久保田 馨, 弦間 昭彦

    肺癌   57 ( 2 )   134 - 135   2017.4

    　More details

    Language：Japanese   Publisher：(NPO)日本肺癌学会  

    researchmap

  • 尿膜管遺残症に対して単孔式腹腔鏡下尿膜管遺残摘出術を施行した1例

    早川 朋宏, 関口 久美子, 原 絵津子, 菊池 友太, 高橋 吾郎, 山初 和也, 勝野 暁, 松田 明久, 櫻澤 信行, 鶴田 宏之, 松本 智司, 堀場 光二, 飯田 信也, 瀬谷 知子, 横室 茂樹, 宮下 正夫, 羽鳥 努

    日本臨床外科学会雑誌   74 ( 12 )   3517 - 3517   2013.12

    　More details

    Language：Japanese   Publisher：日本臨床外科学会  

    researchmap

  • 背部痛を伴う食道粘膜下腫瘍に対する胸腔鏡下切除例

    高橋 吾郎, 櫻澤 信行, 関口 久美子, 原 絵津子, 菊池 友太, 早川 朋宏, 山初 和也, 勝野 暁, 松田 明久, 鶴田 宏之, 松本 智司, 堀場 光二, 瀬谷 知子, 横室 茂樹, 宮下 正夫, 羽鳥 努, 野村 務

    日本臨床外科学会雑誌   74 ( 12 )   3517 - 3517   2013.12

    　More details

    Language：Japanese   Publisher：日本臨床外科学会  

    researchmap

▼display all