Updated on 2025/06/24

写真a

 
Takahashi Shiro
 
Affiliation
Nippon Medical School Hospital, Stroke Care Unit, Assistant Professor
Title
Assistant Professor
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Papers

  • A case of severe ARIA with multiple infarctions and extensive microbleeds following lecanemab administration. International journal

    Akiko Yamazaki, Tetsuro Sekine, Shiro Takahashi, Koji Sohara, Masanori Sakamaki, Takehiko Nagao, Kazumi Kimura, Masahiro Mishina

    Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society   25 ( 1 )   e13231   2025.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/psyg.13231

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  • iPSC-derived mesenchymal stem cells attenuate cerebral ischemia-reperfusion injury by inhibiting inflammatory signaling and oxidative stress. International journal

    Masafumi Arakawa, Yuki Sakamoto, Yoshitaka Miyagawa, Chikako Nito, Shiro Takahashi, Yuko Nitahara-Kasahara, Satoshi Suda, Yoshiyuki Yamazaki, Mashito Sakai, Kazumi Kimura, Takashi Okada

    Molecular therapy. Methods & clinical development   30   333 - 349   2023.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    Induced pluripotent stem cell-derived mesenchymal stem cells (iMSCs) hold great promise as a cell source for transplantation into injured tissues to alleviate inflammation. However, the therapeutic efficacy of iMSC transplantation for ischemic stroke remains unknown. In this study, we evaluated the therapeutic effects of iMSC transplantation on brain injury after ischemia-reperfusion using a rat transient middle cerebral artery occlusion model and compared its therapeutic efficacy with that of bone marrow mesenchymal stem cells (BMMSCs). We showed that iMSCs and BMMSCs reduced infarct volumes after reperfusion and significantly improved motor function on days 3, 7, 14, 28, and 56 and cognitive function on days 28 and 56 after reperfusion compared with the vehicle group. Furthermore, immunological analyses revealed that transplantation of iMSCs and BMMSCs inhibited microglial activation and expression of proinflammatory cytokines and suppressed oxidative stress and neuronal cell death in the cerebral cortex at the ischemic border zone. No difference in therapeutic effect was observed between the iMSC and BMMSC groups. Taken together, our results demonstrate that iMSC therapy can be a practical alternative as a cell source for attenuation of brain injury and improvement of neurological function because of the unlimited supply of uniform therapeutic cells.

    DOI： 10.1016/j.omtm.2023.07.005

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  • "Computed Tomography Perihematomal Rims": A Perihematomal Low-Density Area Is a Part of an Acute Brain Hemorrhage.

    Takahiro Sato, Yasuhiro Nishiyama, Satoshi Suda, Takashi Shimoyama, Shiro Takahashi, Yuki Sakamoto, Junya Aoki, Kentaro Suzuki, Tetsuro Sekine, Shin-Ichiro Kumita, Kazumi Kimura

    Internal medicine (Tokyo, Japan)   60 ( 15 )   2395 - 2403   2021

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    Language：English   Publishing type：Research paper (scientific journal)  

    Objective Computed tomography (CT) can be used for visualizing acute intracerebral hemorrhages (ICHs) as distinct hyperdense areas and cerebral edema as perihematomal low-density areas (LDAs). We observed a perihematomal LDA on CT, which appeared to be part of a hemorrhage on magnetic resonance imaging (MRI) in acute ICH. We named this "CT perihematomal rim" and evaluated its characteristics and clinical significance. Methods We stratified patients with acute ICH according to the presence or absence of a CT perihematomal rim and then compared their radiologic findings. Logistic regression analyses were performed to assess whether the CT findings can predict the presence of a CT perihematomal rim. Patients Patients within 24 hours of ICH onset who were admitted between September 1, 2014, and October 31, 2018, were registered. Results Overall, 139 patients (91 men; mean age, 66 years) were investigated. CT perihematomal rims were observed in 40 patients (29%). ICH volumes on CT were 30% smaller than those on MRI in patients with CT perihematomal rims. On a multivariate analysis, the presence of a CT perihematomal rim was independently associated with the maximum diameter of the perihematomal LDA. According to a receiver operating characteristic analysis, the maximum LDA diameter threshold was 7.5 mm (sensitivity, 85%; specificity, 83%). Conclusion CT perihematomal rims were observed in 29% of the patients with acute ICH. A perihematomal LDA (>7.5 mm) in acute ICH cases should be considered a CT perihematomal rim. Clinicians should be aware that the ICH volume on CT may be underestimated by 30%.

    DOI： 10.2169/internalmedicine.6653-20

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  • Superior binasal quadrantanopsia due to acute ischemic stroke. International journal

    Arata Abe, Yuki Sakamoto, Akane Nogami, Koichiro Nagai, Shiro Takahashi, Madoka Kajio, Chikako Nito, Kazumi Kimura

    Journal of the neurological sciences   369   375 - 376   2016.10

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  • Remote intracerebral hemorrhage followed by re-bleeding after intravenous thrombolysis in a patient taking a non-vitamin K antagonist oral anticoagulant: A case report. International journal

    Yuki Sakamoto, Kumiko Kirita, Madoka Kajio, Chikako Nito, Arata Abe, Akane Nogami, Koichiro Nagai, Shiro Takahashi, Seiji Okubo, Kazumi Kimura

    Journal of the neurological sciences   367   1 - 2   2016.8

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  • Spontaneous Bilateral Cervical Internal Carotid and Vertebral Artery Dissection in a Japanese Patient without Collagen Vascular Disease with Special Reference to Single-Nucleotide Polymorphisms. International journal

    Arata Abe, Chikako Nito, Yuki Sakamoto, Akane Nogami, Hiroyuki Hokama, Shiro Takahashi, Kumiko Kirita, Masayuki Ueda, Yoshiro Ishimaru, Kazumi Kimura

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association   25 ( 8 )   e114-7   2016.8

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    Language：English   Publishing type：Research paper (scientific journal)  

    Spontaneous cervical artery dissection (sCAD) is a major cause of ischemic stroke in young adults. Frequently, sCAD involves multiple neck arteries, accounting for 13%-28% of the total sCAD cases. However, little is known about factors related to multiple sCAD. In this case, a 52-year-old man was admitted due to headache without aura. There was a personal history of migraine with aura and a family history of similar symptoms. The patient's younger brother had a left vertebral artery (VA) dissecting aneurysm and underwent endovascular occlusion of his parent artery at the age of 48. Magnetic resonance imaging of our admitted patient showed hyperintensities in the right internal carotid artery (ICA) without acute infarction, and magnetic resonance angiography revealed a narrowing of the right ICA. Angiography was then performed, which showed a trace of dissection of the left ICA and both VAs as well as the right ICA. The patient did not fulfill any major criteria of collagen vascular disease such as Ehlers-Danlos syndrome type IV or Loeys-Dietz syndrome. The data in our patient are quite similar to those reported in patients with single-nucleotide polymorphism (SNP) of PHACTR1. Obtaining the patient's informed consent, we analyzed a common SNP variation in the rs9349379[G] allele (PHACTR1), which has been reported to be associated with a lower risk of sCAD.

    DOI： 10.1016/j.jstrokecerebrovasdis.2016.04.027

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