Updated on 2025/01/30

写真a

 
Isomura Yohei
 
Affiliation
Nippon Medical School Hospital, Department of Allergy and Rheumatology, Assistant Professor
Title
Assistant Professor
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Degree

  • M.D. ( 2014.3   Nippon Medical School )

Research Interests

  • systemic sclerosis, interstitial lung disease、myocardial diseases

Research Areas

  • Life Science / Connective tissue disease and allergy  / systemic sclerosis

  • Life Science / Cardiology

Education

  • Nippon Medical School   Medical School   Medicine

    2008.4 - 2014.3

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    Country: Japan

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Research History

  • Nippon Medical School   Department of Allergy and Rheumatology   Assistant Professor

    2023.4

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    Country:Japan

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  • Nippon Medical School   Graduate School   Graduate school student

    2018.4 - 2023.3

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    Country:Japan

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  • Saitama City Hospital   Department of Internal Medicine   Resident

    2016.4 - 2018.3

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    Country:Japan

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Professional Memberships

  • Japan College of Rheumatology

    2017.4

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  • Japan Society of Cardilogy

    2016.4

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  • The Japanese Society of Internal Medicine

    2014.4

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Committee Memberships

  • 日本リウマチ学会   基礎研究推進委員会(J-STAR) 国際小委員会(IR)  

    2023.4   

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    Committee type:Academic society

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  • 日本呼吸器学会/日本リウマチ学会 膠原病に伴う間質性肺疾患 診断・治療指針 2025   分担者  

    2023   

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  • 全身性強皮症診療ガイドライン 2023   研究協力者  

    2021 - 2023   

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    Committee type:Academic society

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Papers

  • Seroconversion of Rheumatoid Factor Prior to the Onset of Rheumatoid Arthritis in Patients With Interstitial Lung Disease: A Single‐Center Retrospective Case Series

    Naoshi Nishina, Takahisa Gono, Yohei Isomura, Shinji Watanabe, Yuichiro Shirai, Mitsuhiro Takeno, Masataka Kuwana

    International Journal of Rheumatic Diseases   2024.12

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/1756-185X.70017

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  • Consensus on the assessment of systemic sclerosis-associated primary heart involvement: World Scleroderma Foundation/Heart Failure Association guidance on screening, diagnosis, and follow-up assessment. International journal

    Cosimo Bruni, Maya H Buch, Aleksandra Djokovic, Giacomo De Luca, Raluca B Dumitru, Alessandro Giollo, Ilaria Galetti, Alexia Steelandt, Konstantinos Bratis, Yossra Atef Suliman, Ivan Milinkovic, Anna Baritussio, Ghadeer Hasan, Anastasia Xintarakou, Yohei Isomura, George Markousis-Mavrogenis, Sophie Mavrogeni, Luna Gargani, Alida Lp Caforio, Carsten Tschöpe, Arsen Ristic, Sven Plein, Elijah Behr, Yannick Allanore, Masataka Kuwana, Christopher P Denton, Daniel E Furst, Dinesh Khanna, Thomas Krieg, Renzo Marcolongo, Alessia Pepe, Oliver Distler, Petros Sfikakis, Petar Seferovic, Marco Matucci-Cerinic

    Journal of scleroderma and related disorders   8 ( 3 )   169 - 182   2023.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    INTRODUCTION: Heart involvement is a common problem in systemic sclerosis. Recently, a definition of systemic sclerosis primary heart involvement had been proposed. Our aim was to establish consensus guidance on the screening, diagnosis and follow-up of systemic sclerosis primary heart involvement patients. METHODS: A systematic literature review was performed to investigate the tests used to evaluate heart involvement in systemic sclerosis. The extracted data were categorized into relevant domains (conventional radiology, electrocardiography, echocardiography, cardiac magnetic resonance imaging, laboratory, and others) and presented to experts and one patient research partner, who discussed the data and added their opinion. This led to the formulation of overarching principles and guidance statements, then reviewed and voted on for agreement. Consensus was attained when the mean agreement was ⩾7/10 and of ⩾70% of voters. RESULTS: Among 2650 publications, 168 met eligibility criteria; the data extracted were discussed over three meetings. Seven overarching principles and 10 guidance points were created, revised and voted on. The consensus highlighted the importance of patient counseling, differential diagnosis and multidisciplinary team management, as well as defining screening and diagnostic approaches. The initial core evaluation should integrate history, physical examination, rest electrocardiography, trans-thoracic echocardiography and standard serum cardiac biomarkers. Further investigations should be individually tailored and decided through a multidisciplinary management. The overall mean agreement was 9.1/10, with mean 93% of experts voting above 7/10. CONCLUSION: This consensus-based guidance on screening, diagnosis and follow-up of systemic sclerosis primary heart involvement provides a foundation for standard of care and future feasibility studies that are ongoing to support its application in clinical practice.

    DOI: 10.1177/23971983231163413

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  • Clinical worsening following discontinuation of tocilizumab in diffuse cutaneous systemic sclerosis: a single-centre experience in Japan. International journal

    Yohei Isomura, Yuichiro Shirai, Masataka Kuwana

    Rheumatology (Oxford, England)   61 ( 11 )   4491 - 4496   2022.11

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    OBJECTIVE: To investigate outcomes following the tapering or discontinuation of tocilizumab in patients with diffuse cutaneous SSc (dcSSc) in a real-world setting. METHODS: Fifteen patients who were treated with tocilizumab for dcSSc were selected from a single-centre cohort database and were evaluated for serial changes in the modified Rodnan total skin thickness score (mRSS) and predicted forced vital capacity (FVC) and the occurrence of clinical worsening events after the introduction of tocilizumab. RESULTS: Over 12 months of treatment with tocilizumab, the mRSS decreased from 20.4 ± 10.7 to 12.3 ± 8.5 (P = 0.003) and FVC increased from 84.3 ± 13.7% to 88.5 ± 16.4% (P = 0.04). Tocilizumab was tapered or discontinued in seven and three patients, respectively, after improvement in skin thickening without occurrence or progression of organ manifestations. One (14%) of seven patients who underwent tocilizumab tapering experienced a worsening of skin thickening, while all three patients who discontinued tocilizumab experienced a worsening of skin thickening and/or new development of pericarditis, arthritis, interstitial lung disease or pulmonary arterial hypertension. The additional patient who discontinued tocilizumab due to an adverse event experienced subsequent progression of multiple organ manifestations, including skin, lung, lower gastrointestinal and renal involvement, leading to mortality. CONCLUSION: Our findings suggest potential benefits of prolonged tocilizumab use in dcSSc patients. The discontinuation of tocilizumab can lead to the progression of skin and visceral manifestations. Tapering rather than the discontinuation of tocilizumab is a viable option in dcSSc patients who experience remarkable clinical improvement.

    DOI: 10.1093/rheumatology/keac136

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  • Primary systemic sclerosis heart involvement: A systematic literature review and preliminary data-driven, consensus-based WSF/HFA definition. International journal

    Cosimo Bruni, Maya H Buch, Daniel E Furst, Giacomo De Luca, Aleksandra Djokovic, Raluca B Dumitru, Alessandro Giollo, Marija Polovina, Alexia Steelandt, Kostantinos Bratis, Yossra Atef Suliman, Ivan Milinkovic, Anna Baritussio, Ghadeer Hasan, Anastasia Xintarakou, Yohei Isomura, George Markousis-Mavrogenis, Lorenzo Tofani, Sophie Mavrogeni, Luna Gargani, Alida Lp Caforio, Carsten Tschöpe, Arsen Ristic, Karin Klingel, Sven Plein, Elijah R Behr, Yannick Allanore, Masataka Kuwana, Christopher P Denton, Dinesh Khanna, Thomas Krieg, Renzo Marcolongo, Ilaria Galetti, Elisabetta Zanatta, Francesco Tona, Petar Seferovic, Marco Matucci-Cerinic

    Journal of scleroderma and related disorders   7 ( 1 )   24 - 32   2022.2

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    INTRODUCTION: Primary heart involvement in systemic sclerosis may cause morpho-functional and electrical cardiac abnormalities and is a common cause of death. The absence of a clear definition of primary heart involvement in systemic sclerosis limits our understanding and ability to focus on clinical research. We aimed to create an expert consensus definition for primary heart involvement in systemic sclerosis. METHODS: A systematic literature review of cardiac involvement and manifestations in systemic sclerosis was conducted to inform an international and multi-disciplinary task force. In addition, the nominal group technique was used to derive a definition that was then subject to voting. A total of 16 clinical cases were evaluated to test face validity, feasibility, reliability and criterion validity of the newly created definition. RESULTS: In total, 171 publications met eligibility criteria. Using the nominal group technique, experts added their opinion, provided statements to consider and ranked them to create the consensus definition, which received 100% agreement on face validity. A median 60(5-300) seconds was taken for the feasibility on a single case. Inter-rater agreement was moderate (mKappa (95% CI) = 0.56 (0.46-1.00) for the first round and 0.55 (0.44-1.00) for the second round) and intra-rater agreement was good (mKappa (95% CI) = 0.77 (0.47-1.00)). Criterion validity showed a 78 (73-84)% correctness versus gold standard. CONCLUSION: A preliminary primary heart involvement in systemic sclerosis consensus-based definition was created and partially validated, for use in future clinical research.

    DOI: 10.1177/23971983211053246

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Misc.

  • びまん皮膚硬化型全身性強皮症におけるトシリズマブ治療継続の意義

    磯村 洋平, 白井 悠一郎, 桑名 正隆

    リウマチ科   70 ( 4 )   404 - 409   2023.10

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    Language:Japanese   Publisher:(有)科学評論社  

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  • 強皮症の病態 全身性強皮症に伴う心筋病変のトランスクリプトーム解析

    磯村 洋平, 桑名 正隆

    日本リウマチ学会総会・学術集会プログラム・抄録集   67回   571 - 571   2023.3

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    Language:Japanese   Publisher:(一社)日本リウマチ学会  

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  • 心室中隔欠損症を合併した全身性強皮症に伴う肺動脈性肺高血圧の一例

    佐々木優李, 磯村洋平, 五野貴久, 桑名正隆

    日本臨床リウマチ学会プログラム・抄録集   38th   2023

  • 全身性強皮症に伴う間質性肺疾患ではニンテダニブ投与により血清KL-6が減少する(第2報)

    磯村 洋平, 桑名 正隆

    日本リウマチ学会総会・学術集会プログラム・抄録集   66回   654 - 654   2022.3

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  • 強皮症・MCTD・重複症候群 びまん皮膚硬化型全身性強皮症におけるトシリズマブ減量・中止後の転帰

    磯村 洋平, 山崎 宜興, 白井 悠一郎, 桑名 正隆

    日本リウマチ学会総会・学術集会プログラム・抄録集   65回   387 - 387   2021.3

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  • 強皮症・MCTD・重複症候群 全身性強皮症に伴う間質性肺疾患ではニンテダニブ投与により血清KL-6は低下する

    山崎 宜興, 磯村 洋平, 桑名 正隆

    日本リウマチ学会総会・学術集会プログラム・抄録集   65回   389 - 389   2021.3

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  • 全身性強皮症(SSc)に伴う心病変の臨床特徴

    磯村 洋平, 白井 悠一郎, 五野 貴久, 岳野 光洋, 桑名 正隆

    日本リウマチ学会総会・学術集会プログラム・抄録集   64回   593 - 593   2020.8

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    Language:Japanese   Publisher:(一社)日本リウマチ学会  

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  • アダリムマブ中止後にMycobacterium aviumによる皮膚潰瘍が増悪した関節リウマチの一例

    磯村 洋平, 渡邊 普二, 白井 悠一郎, 小林 政司, 五野 貴久, 岳野 光洋, 桑名 正隆

    日本リウマチ学会総会・学術集会プログラム・抄録集   63回   653 - 653   2019.3

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  • アダリムマブ中止後にMycobacterium aviumによる皮膚潰瘍が増悪した関節リウマチの一例

    磯村 洋平, 渡邊 普二, 白井 悠一郎, 小林 政司, 五野 貴久, 岳野 光洋, 桑名 正隆

    日本リウマチ学会総会・学術集会プログラム・抄録集   63回   653 - 653   2019.3

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  • PGE1無効指尖潰瘍に対するボセンタンの効果

    広瀬 立夫, 磯村 洋平, 田坂 祐司

    日本リウマチ学会総会・学術集会プログラム・抄録集   62回   744 - 744   2018.3

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  • 末梢血で好酸球増多を呈し、トキソカラ症の診断で自然軽快した1例

    山岡 広季, 磯村 洋平, 関根 克敏, 藤井 千華子, 田坂 祐司, 細井 雅孝, 渡辺 卓郎, 川田 真幹, 廣瀬 立夫, 小山 卓史

    日本内科学会関東地方会   639回   48 - 48   2018.2

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  • 間質性腎障害を合併した成人スチル病の1例

    青山 和樹, 磯村 洋平, 田坂 祐司, 関根 克敏, 藤井 千華子, 細井 雅孝, 渡辺 卓郎, 廣瀬 立夫

    日本内科学会関東地方会   636回   37 - 37   2017.10

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