Updated on 2025/01/28

写真a

 
Matsumoto Yukiko
 
Affiliation
Nippon Medical School Hospital, Department of Neuropsychiatry, Associate Professor
Title
Associate Professor
External link

Research Interests

  • 認知神経科学

  • 脳MRI

  • 精神医学

Research Areas

  • Life Science / Psychiatry

Research History

  • Nippon Medical School   Department of Neuropsychiatry   Associate Professor

    2024.10

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  • Nippon Medical School   Department of Neuropsychiatry   Lecturer

    2023.4 - 2024.9

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  • Tokyo Medical and Dental University   Graduate School of Medical and Dental Sciences Medical and Dental Sciences - -   Assistant Professor

    2019.12 - 2023.3

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  • Tokyo Medical and Dental University   Graduate School of Medical and Dental Sciences Medical and Dental Sciences - -   Visiting Lecturer

    2019.5 - 2019.11

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  • Kyoto University   Assistant Professor

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  • Kyoto University

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Papers

  • 肥満症の行動療法

    松本 有紀子

    日本医科大学医学会雑誌   20 ( 4 )   271 - 275   2024.12

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    Language:Japanese   Publisher:日本医科大学医学会  

    DOI: 10.1272/manms.20.271

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  • Homogenization of word relationships in schizophrenia: Topological analysis of cortical semantic representations Reviewed

    Ryusuke Hayashi, Shizuo Kaji, Yukiko Matsumoto, Satoshi Nishida, Shinji Nishimoto, Hidehiko Takahashi

    Psychiatry and Clinical Neurosciences   78 ( 11 )   687 - 695   2024.8

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    Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    Aim

    Patients with schizophrenia typically exhibit symptoms of disorganized thought and display concreteness and over‐inclusion in verbal reports, depending on the level of abstraction. While concreteness and over‐inclusion may appear contradictory, the underlying psychopathology that explains these symptoms remains unclear. In the current study, we used functional magnetic resonance imaging with an encoding modeling approach to examine how concepts of various words, represented as brain activity, are anomalously connected at different levels of abstraction in patients with schizophrenia.

    Methods

    Fourteen individuals diagnosed with schizophrenia and 17 healthy controls underwent functional magnetic resonance imaging to measure brain activity representing concepts of various words. We used a persistent homology (PH) method to analyze the topological structures of word representations in schizophrenia patients, healthy controls, and random data, across different levels of abstraction by varying dissimilarity scales in the representation space.

    Results

    The results revealed that patients with schizophrenia exhibited more homogeneous word relationships across different levels of abstraction compared with healthy controls. Additionally, topological structures exhibited a shift toward a random network structure in patients with schizophrenia compared with controls. The PH method successfully distinguished semantic representations of patients with schizophrenia from those of controls.

    Conclusions

    The current results provide an explanation for the mechanisms underlying the deficits in abstraction ability observed in schizophrenia. The isotopic connection of individual concepts reflects both the reduction of contextual connections at a semantically fine‐grained scale and the absence of clear boundaries between related concepts at a coarse scale, which lead to concreteness and over‐inclusion, respectively.

    DOI: 10.1111/pcn.13727

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  • 老年期反復性うつ病が前駆したアルツハイマー型認知症の1例

    比留間 達之, 大矢 智之, 山本 憲, 坂寄 健, 野上 毅, 松本 有紀子, 舘野 周

    精神神経学雑誌   126 ( 5 )   339 - 339   2024.5

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    Language:Japanese   Publisher:(公社)日本精神神経学会  

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  • 夜間の不安焦燥を主訴に入院後,癒着性腸閉塞に起因するせん妄と診断し加療した1例

    齊藤 誠人, 塩飽 裕紀, 治徳 大介, 松本 有紀子, 田村 赳紘, 杉原 玄一, 高橋 英彦

    精神神経学雑誌   125 ( 9 )   820 - 820   2023.9

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  • 血漿交換療法が著効した自己免疫性脳症の1例

    山口 湧声, 塩飽 裕紀, 松本 有紀子, 治徳 大介, 杉原 玄一, 高橋 英彦

    精神神経学雑誌   125 ( 9 )   824 - 824   2023.9

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  • 【統合失調症の未来-研究と治療】脳ネットワーク 統合失調症における脳内意味ネットワーク異常と連合弛緩

    松本 有紀子, 高橋 英彦

    医学のあゆみ   286 ( 6 )   583 - 587   2023.8

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    Language:Japanese   Publisher:医歯薬出版(株)  

    統合失調症の連合弛緩にみられる意味関係の異常は,これまで心理実験によリ検証されてきたが,その脳内機序は不明であった.本稿ではまず,ものの意味関係を表す"意味ネットワーク"の理輪的枠組みを概観した後,脳活動に基づく意味ネットワークの構造特性を評価した筆者らの研究を紹介する.自然動画提示下fMRI(functional MRI)データに自然言語処理アルゴリズムとエンコーディングモデリングを適用して脳内意味表象を定量化し,その類似度に基づく脳内意味ネットワークの構造を評価した.その結果,統合失調症患者の脳内意味ナットワークは健常人よりもスモールワールド性が減少し,ランダム化していることが明らかになった.本研究の手法は患者の主観的体験を脳活動から直接評価できる点で,精神科医療における新規診断・治療法開発への応用が期待される.(著者抄録)

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    Other Link: https://search.jamas.or.jp/default/link?pub_year=2023&ichushi_jid=J00060&link_issn=&doc_id=20230808040013&doc_link_id=issn%3D0039-2359%26volume%3D286%26issue%3D6%26spage%3D583&url=http%3A%2F%2Fwww.pieronline.jp%2Fopenurl%3Fissn%3D0039-2359%26volume%3D286%26issue%3D6%26spage%3D583&type=PierOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00005_2.gif

  • 多彩な視覚症状を呈したもやもや病の1例

    鈴木 貴久, 山口 湧声, 松本 有紀子, 塩飽 裕紀, 田村 赳紘, 杉原 玄一, 高橋 英彦

    精神神経学雑誌   125 ( 5 )   445 - 445   2023.5

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    Language:Japanese   Publisher:(公社)日本精神神経学会  

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  • Disorganization of Semantic Brain Networks in Schizophrenia Revealed by fMRI Reviewed

    Yukiko Matsumoto, Satoshi Nishida, Ryusuke Hayashi, Shuraku Son, Akio Murakami, Naganobu Yoshikawa, Hiroyoshi Ito, Naoya Oishi, Naoki Masuda, Toshiya Murai, Karl Friston, Shinji Nishimoto, Hidehiko Takahashi

    Schizophrenia Bulletin   2022.12

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Oxford University Press (OUP)  

    Abstract

    Objectives

    Schizophrenia is a mental illness that presents with thought disorders including delusions and disorganized speech. Thought disorders have been regarded as a consequence of the loosening of associations between semantic concepts since the term “schizophrenia” was first coined by Bleuler. However, a mechanistic account of this cardinal disturbance in terms of functional dysconnection has been lacking. To evaluate how aberrant semantic connections are expressed through brain activity, we characterized large-scale network structures of concept representations using functional magnetic resonance imaging (fMRI).

    Study Design

    We quantified various concept representations in patients’ brains from fMRI activity evoked by movie scenes using encoding modeling. We then constructed semantic brain networks by evaluating the similarity of these semantic representations and conducted graph theory-based network analyses.

    Study Results

    Neurotypical networks had small-world properties similar to those of natural languages, suggesting small-worldness as a universal property in semantic knowledge networks. Conversely, small-worldness was significantly reduced in networks of schizophrenia patients and was correlated with psychological measures of delusions. Patients’ semantic networks were partitioned into more distinct categories and had more random within-category structures than those of controls.

    Conclusions

    The differences in conceptual representations manifest altered semantic clustering and associative intrusions that underlie thought disorders. This is the first study to provide pathophysiological evidence for the loosening of associations as reflected in randomization of semantic networks in schizophrenia. Our method provides a promising approach for understanding the neural basis of altered or creative inner experiences of individuals with mental illness or exceptional abilities, respectively.

    DOI: 10.1093/schbul/sbac157

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  • 分子標的薬ロルラチニブによる夜間異常行動が疑われた70歳代男性の1例

    銭 梨璃奈, 本川 友紀子, 石原 拓也, 北島 祐輔, 松本 有紀子, 田村 赳紘, 高木 俊輔, 竹内 崇, 杉原 玄一, 高橋 英彦

    精神神経学雑誌   124 ( 11 )   819 - 819   2022.11

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  • 分子標的薬ロルラチニブによる夜間異常行動が疑われた70歳代男性の1例

    銭 梨璃奈, 本川 友紀子, 石原 拓也, 北島 祐輔, 松本 有紀子, 田村 赳紘, 高木 俊輔, 竹内 崇, 杉原 玄一, 高橋 英彦

    精神神経学雑誌   124 ( 11 )   819 - 819   2022.11

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  • 微弱な陽性症状を伴わないARMSへの治療的介入についての考察

    内山 紗也, 八幡 拓実, 本川 友紀子, 涌井 隆行, 田村 赳紘, 松本 有紀子, 高木 俊輔, 杉原 玄一, 高橋 英彦

    精神神経学雑誌   124 ( 6 )   418 - 418   2022.6

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  • パーキンソニズムが主体の多系統萎縮症(MSA-P)に伴う精神病症状に修正型電気けいれん療法(mECT)がした1例

    八幡 拓実, 内山 紗也, 本川 友紀子, 涌井 隆行, 田村 赳紘, 高木 俊輔, 松本 有紀子, 杉原 玄一, 高橋 英彦

    精神神経学雑誌   124 ( 6 )   423 - 423   2022.6

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  • パーキンソニズムが主体の多系統萎縮症(MSA-P)に伴う精神病症状に修正型電気けいれん療法(mECT)がした1例

    八幡 拓実, 内山 紗也, 本川 友紀子, 涌井 隆行, 田村 赳紘, 高木 俊輔, 松本 有紀子, 杉原 玄一, 高橋 英彦

    精神神経学雑誌   124 ( 6 )   423 - 423   2022.6

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    Language:Japanese   Publisher:(公社)日本精神神経学会  

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  • 失語症や失声症との鑑別を要した緘黙を主体とするうつ病性カタトニアの1例

    上田 光人, 林 賢秀, 沢尻 修司, 丸尾 享司, 市橋 雅典, 宮島 美穂, 松本 有紀子, 塩飽 裕紀, 田村 赳紘, 高木 俊輔, 竹内 崇, 杉原 玄一, 高橋 英彦

    精神神経学雑誌   123 ( 8 )   530 - 530   2021.8

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  • Factors affecting mental illness and social stress in hospital workers treating COVID-19: Paradoxical distress during pandemic era. Reviewed International journal

    Yukiko Matsumoto, Junya Fujino, Hiroki Shiwaku, Miho Miyajima, Satomi Doi, Nobuhide Hirai, Daisuke Jitoku, Shunsuke Takagi, Takehiro Tamura, Takashi Maruo, Yuki Shidei, Nanase Kobayashi, Masanori Ichihashi, Shiori Noguchi, Kanako Oohashi, Takashi Takeuchi, Genichi Sugihara, Takayuki Okada, Takeo Fujiwara, Hidehiko Takahashi

    Journal of psychiatric research   137   298 - 302   2021.5

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    BACKGROUND: The coronavirus disease 2019 (COVID-19) has affected all countries in the world. Hospital workers are at high risk of mental illness, such as anxiety and depression. Furthermore, they also face many social stresses, such as deterioration of human relations and income reduction. Apart from mental illness, these social stresses can reduce motivation and lead to voluntary absenteeism, which contribute to a collapse of medical systems. Thus, for maintaining medical systems, it is crucial to clarify risk factors for both mental illness and increased social stress among hospital workers. However, little attention has been paid to factors affecting social stress, and thus, we aimed to address this gap. METHODS: In this cross-sectional survey of 588 hospital workers, the levels of anxiety, depression, and social stress were assessed using the 7-item Generalized Anxiety Disorder scale (GAD-7), 9-item Patient Health Questionnaire (PHQ-9), and Tokyo Metropolitan Distress Scale for Pandemic (TMDP). Multiple regression analyses were conducted to identify the demographic variables affecting these problems. RESULTS: Older age and female sex were common risk factors for anxiety, depression, and social stress. Moreover, occupational exposure to COVID-19 and hospital staff other than doctors/fewer non-work days were risk factors for increased anxiety and depression, respectively. Furthermore, living with families/others was a risk factor for increased social stress during this pandemic. CONCLUSION: Our findings could be useful for developing policies and practices to minimize the risk of mental illness and increased social stress among hospital workers, highlighting that attention should be paid to social factors, such as an individual's household situation.

    DOI: 10.1016/j.jpsychires.2021.03.007

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  • Novel brief screening scale, Tokyo Metropolitan Distress Scale for Pandemic (TMDP), for assessing mental and social stress of medical personnel in COVID-19 pandemic. Reviewed International journal

    Hiroki Shiwaku, Satomi Doi, Miho Miyajima, Yukiko Matsumoto, Junya Fujino, Nobuhide Hirai, Daisuke Jitoku, Shunsuke Takagi, Takehiro Tamura, Takashi Maruo, Yuki Shidei, Nanase Kobayashi, Masanori Ichihashi, Shiori Noguchi, Kanako Oohashi, Takashi Takeuchi, Genichi Sugihara, Takayuki Okada, Takeo Fujiwara, Hidehiko Takahashi

    Psychiatry Clin Neurosci   75 ( 1 )   24 - 25   2021

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    DOI: 10.1111/pcn.13168

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  • 統合失調感情障害のうつ状態と診断されたが後にせん妄と判明した一症例

    土井 善貴, 佐々木 健至, 梅田 百希, 森田 麗奈, 池上 美和, 藤林 一保, 涌井 隆行, 松本 有紀子, 白木 明雄, 益冨 一郎, 尾崎 茂

    総合病院精神医学   32 ( Suppl. )   S - 139   2020.11

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    Language:Japanese   Publisher:(一社)日本総合病院精神医学会  

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  • 東京医科歯科大学におけるCOVID-19に関連した職員メンタルヘルスの実際

    治徳 大介, 竹内 崇, 丸尾 享司, 杉原 玄一, 松岡 裕美, 平井 伸英, 三宅 智, 野口 詩織, 大橋 花菜子, 四手井 友紀, 市橋 雅典, 小林 七彩, 藤野 純也, 塩飽 裕紀, 田村 赳紘, 高木 俊輔, 松本 有紀子, 宮島 美穂, 高橋 英彦

    総合病院精神医学   32 ( Suppl. )   S - 204   2020.11

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  • Reduced intra- and inter-individual diversity of semantic representations in the brains of schizophrenia patients

    Satoshi Nishida, Yukiko Matsumoto, Naganobu Yoshikawa, Shuraku Son, Akio Murakami, Ryusuke Hayashi, Shinji Nishimoto, Hidehiko Takahashi

    https://doi.org/10.1101/2020.06.03.132928   2020.6

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    Publisher:Cold Spring Harbor Laboratory  

    <title>Abstract</title>Schizophrenia patients often manifest semantic processing deficits. It has been proposed that these deficits stem from disorganized semantic representations in the brain. However, no study has yet examined the neural correlates of semantic disorganization by directly evaluating semantic representations in the brain. We used voxelwise modeling on functional magnetic resonance imaging signals to evaluate the semantic representations associated with several thousand words in individual patient brains. We then compared the structural properties of semantic representations to those in healthy controls. The variability of semantic representations was smaller both within individual patients and across patients compared to controls. Surrogate data analysis suggests that the observed reduction in representational variability is associated with disorganization of categorical information. To our knowledge, these findings provide the first evidence for sematic disorganization in schizophrenia at the level of brain representations.

    DOI: 10.1101/2020.06.03.132928

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  • 統合失調症患者における脳内意味表現のネットワーク異常

    林 隆介, 松本 有紀子, 西田 知史, 孫 樹洛, 村上 晶郎, 吉川 長伸, 西本 伸志, 高橋 英彦

    Vision   32 ( 1 )   24 - 24   2020.1

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    Language:Japanese   Publisher:日本視覚学会  

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  • Overlapping but Asymmetrical Relationships Between Schizophrenia and Autism Revealed by Brain Connectivity. Reviewed International journal

    Yujiro Yoshihara, Giuseppe Lisi, Noriaki Yahata, Junya Fujino, Yukiko Matsumoto, Jun Miyata, Gen-Ichi Sugihara, Shin-Ichi Urayama, Manabu Kubota, Masahiro Yamashita, Ryuichiro Hashimoto, Naho Ichikawa, Weipke Cahn, Neeltje E M, van Haren, Susumu Mori, Yasumasa Okamoto, Kiyoto Kasai, Nobumasa Kato, Hiroshi Imamizu, René S Kahn, Akira Sawa, Mitsuo Kawato, Toshiya Murai, Jun Morimoto, Hidehiko Takahashi

    Schizophr Bull   46 ( 5 )   1210 - 1218   2020

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    Although the relationship between schizophrenia spectrum disorder (SSD) and autism spectrum disorder (ASD) has long been debated, it has not yet been fully elucidated. The authors quantified and visualized the relationship between ASD and SSD using dual classifiers that discriminate patients from healthy controls (HCs) based on resting-state functional connectivity magnetic resonance imaging. To develop a reliable SSD classifier, sophisticated machine-learning algorithms that automatically selected SSD-specific functional connections were applied to Japanese datasets from Kyoto University Hospital (N = 170) including patients with chronic-stage SSD. The generalizability of the SSD classifier was tested by 2 independent validation cohorts, and 1 cohort including first-episode schizophrenia. The specificity of the SSD classifier was tested by 2 Japanese cohorts of ASD and major depressive disorder. The weighted linear summation of the classifier's functional connections constituted the biological dimensions representing neural classification certainty for the disorders. Our previously developed ASD classifier was used as ASD dimension. Distributions of individuals with SSD, ASD, and HCs s were examined on the SSD and ASD biological dimensions. We found that the SSD and ASD populations exhibited overlapping but asymmetrical patterns in the 2 biological dimensions. That is, the SSD population showed increased classification certainty for the ASD dimension but not vice versa. Furthermore, the 2 dimensions were correlated within the ASD population but not the SSD population. In conclusion, using the 2 biological dimensions based on resting-state functional connectivity enabled us to discover the quantified relationships between SSD and ASD.

    DOI: 10.1093/schbul/sbaa021

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  • Early and late effects of electroconvulsive therapy associated with different temporal lobe structures. Reviewed International journal

    Shimpei Yamasaki, Toshihiko Aso, Jun Miyata, Genichi Sugihara, Masaaki Hazama, Kiyotaka Nemoto, Yujiro Yoshihara, Yukiko Matsumoto, Tomohisa Okada, Kaori Togashi, Toshiya Murai, Hidehiko Takahashi, Taro Suwa

    Transl Psychiatry   10 ( 1 )   344 - 344   2020

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    Recent studies examining electroconvulsive therapy (ECT) have reported that early sessions can induce rapid antidepressant and antipsychotic effects, and the early termination of ECT was reported to increase the risk of relapse. We hypothesized that different neural mechanisms associated with the therapeutic effects of ECT may be involved in the different responses observed during the early and late periods of ECT treatment. We investigated whether these antidepressant and antipsychotic effects were associated with temporally and spatially different regional gray matter volume (GMV) changes during ECT. Fourteen patients with major depressive disorder, with or without psychotic features, underwent 3-Tesla structural magnetic resonance imaging scans before (time point [Tp] 1), after the fifth or sixth ECT session (Tp2), and after ECT completion (Tp3). We investigated the regions in which GMV changed between Tp1 and Tp2, Tp2 and Tp3, and Tp1 and Tp3 using voxel-based morphometry. In addition, we investigated the association between regional GMV changes and improvement in depressive or psychotic symptoms. GMV increase in the left superior and inferior temporal gyrus during Tp1-Tp2 was associated with improvement in psychotic symptoms (P < 0.025). GMV increase in the left hippocampus was associated with improvement of depressive symptoms in Tp2-Tp3 (P < 0.05). Our findings suggest that different temporal lobe structures are associated with early antipsychotic and late antidepressant effects of ECT.

    DOI: 10.1038/s41398-020-01025-8

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  • Cognition and interpersonal coordination of patients with schizophrenia who have sports habits. Reviewed International journal

    Keisuke Fujii, Yujiro Yoshihara, Yukiko Matsumoto, Keima Tose, Hideaki Takeuchi, Masanori Isobe, Hiroto Mizuta, Daisuke Maniwa, Takehiko Okamura, Toshiya Murai, Yoshinobu Kawahara, Hidehiko Takahashi

    PLoS One   15 ( 11 )   e0241863 - e0241863   2020

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    Team sports activities are effective for improving the negative symptoms and cognitive functions in patients with schizophrenia. However, the interpersonal coordination during the sports and visual cognition of patients with schizophrenia who have team sports habits are unknown. The main objectives of this study were to test two hypotheses: first, patients with schizophrenia perform the skill requiring ball passing and receiving worse than healthy controls; and second, the patients will be impaired in these functionings in accordance with the previous studies regarding schizophrenia in general. Twelve patients with schizophrenia and 15 healthy controls, who had habits in football, participated in this study. The participants performed three conventional cognitive tests and a 3-vs-1 ball possession task to evaluate their interpersonal coordination. The results showed that in the 3-vs-1 possession task, the displacement in the pass angle for the patients was significantly smaller than that for the control. The recall in the complex figure test, the performance in the trail making test, and that in the five-choice reaction task for the patients were worse than those for the control. Moreover, we found the significant partial correlations in the patients between the extradimensional shift error and the pass angle as well as between the time in the trail making test and the displacement in the pass angle, whereas there was no significant correlation in the control group. This study clarified the impaired interpersonal coordination during team sports and the visual cognition of patients with schizophrenia who have team sports habits.

    DOI: 10.1371/journal.pone.0241863

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  • 幻聴・妄想を認めLewy小体型認知症と診断した1例

    澤木 悠人, 大月 美輝, 松本 有紀子, 村井 俊哉

    精神神経学雑誌   121 ( 3 )   227 - 227   2019.3

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  • 潰瘍性大腸炎・広汎性発達障害に合併したうつ病の1例

    岩木 恵実, 松本 有紀子, 村井 俊哉

    精神神経学雑誌   121 ( 1 )   71 - 71   2019.1

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  • Neural basis of altered earlier attention and higher order biological motion processing in schizophrenia.

    Matsumoto Y, Takahashi H, Miyata J, Sugihara G, Murai T, Takahashi H

    Social neuroscience   13 ( 5 )   594 - 601   2018.10

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  • Additive Effect of Cigarette Smoking on Gray Matter Abnormalities in Schizophrenia.

    Yokoyama N, Sasaki H, Mori Y, Ono M, Tsurumi K, Kawada R, Matsumoto Y, Yoshihara Y, Sugihara G, Miyata J, Murai T, Takahashi H

    Schizophrenia bulletin   44 ( 3 )   535 - 541   2018.4

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Oxford University Press (OUP)  

    DOI: 10.1093/schbul/sbx092

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  • 統合失調症の思考障害と脳内意味表象異常

    松本 有紀子, 高橋 英彦

    Medical Science Digest   44 ( 2 )   70 - 72   2018.2

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    Language:Japanese   Publisher:(株)ニュー・サイエンス社  

    思考障害は統合失調症の主要な症状であり、中でも連合弛緩は、概念形成、カテゴリー化、意味記憶との関連から、具象化・過包括、意味ネットワークにおける伝播異常、意味記憶の貯蔵およびアクセス障害など、さまざまな仮説が提唱されてきた。近年、fMRIを用いたエンコーディングによる高次視覚野応答のモデル化が可能となり、著者らは統合失調症における脳内意味表象の可視化・定量化を行っている。こうした計算技術は、思考という内的過程へのアプローチにおいて、精神科臨床に新たな視点をもたらすことが期待される。(著者抄録)

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  • Visual processing and social cognition in schizophrenia: relationships among eye movements, biological motion perception, and empathy. Reviewed International journal

    Yukiko Matsumoto, Hideyuki Takahashi, Toshiya Murai, Hidehiko Takahashi

    Neurosci Res   90   95 - 100   2015.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    Schizophrenia patients have impairments at several levels of cognition including visual attention (eye movements), perception, and social cognition. However, it remains unclear how lower-level cognitive deficits influence higher-level cognition. To elucidate the hierarchical path linking deficient cognitions, we focused on biological motion perception, which is involved in both the early stage of visual perception (attention) and higher social cognition, and is impaired in schizophrenia. Seventeen schizophrenia patients and 18 healthy controls participated in the study. Using point-light walker stimuli, we examined eye movements during biological motion perception in schizophrenia. We assessed relationships among eye movements, biological motion perception and empathy. In the biological motion detection task, schizophrenia patients showed lower accuracy and fixated longer than healthy controls. As opposed to controls, patients exhibiting longer fixation durations and fewer numbers of fixations demonstrated higher accuracy. Additionally, in the patient group, the correlations between accuracy and affective empathy index and between eye movement index and affective empathy index were significant. The altered gaze patterns in patients indicate that top-down attention compensates for impaired bottom-up attention. Furthermore, aberrant eye movements might lead to deficits in biological motion perception and finally link to social cognitive impairments. The current findings merit further investigation for understanding the mechanism of social cognitive training and its development.

    DOI: 10.1016/j.neures.2014.10.011

    PubMed

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Misc.

  • 発達障害,うつ病を伴う高度肥満患者に対し肥満減量手術を検討した1例

    川端 留里佐, 秋山 友美, 山本 憲, 松本 有紀子, 舘野 周

    精神神経学雑誌   126 ( 5 )   338 - 338   2024.5

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    Language:Japanese   Publisher:(公社)日本精神神経学会  

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  • 微弱な陽性症状を伴わないARMSへの治療的介入についての考察

    内山 紗也, 八幡 拓実, 本川 友紀子, 涌井 隆行, 田村 赳紘, 松本 有紀子, 高木 俊輔, 杉原 玄一, 高橋 英彦

    精神神経学雑誌   124 ( 6 )   418 - 418   2022.6

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    Language:Japanese   Publisher:(公社)日本精神神経学会  

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  • 複数の嗜癖性障害の合併を契機にADHD不注意型と診断された1例

    市橋 雅典, 四方 昭義, 丸尾 享司, 田村 赳紘, 松本 有紀子, 高木 俊輔, 杉原 玄一, 高橋 英彦

    精神神経学雑誌   123 ( 8 )   531 - 531   2021.8

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    Language:Japanese   Publisher:(公社)日本精神神経学会  

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Research Projects

  • 統合失調症の概念形成および記憶統合障害に関与する神経基盤の計算論的検討

    Grant number:22K07612  2022.4 - 2025.3

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    松本 有紀子

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    Grant amount:\3770000 ( Direct Cost: \2900000 、 Indirect Cost:\870000 )

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  • 統合失調症の身体運動認知における運動リハビリテーション効果の神経科学的検討

    2018.4 - 2023.3

    日本学術振興会  科学研究費助成事業 若手研究  若手研究

    松本 有紀子

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    Authorship:Principal investigator  Grant type:Competitive

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  • Integrative elucidation of the neural basis of social cognitive rehabilitation effect in schizophrenia

    Grant number:15K19723  2015.4 - 2019.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)  Grant-in-Aid for Young Scientists (B)

    Matsumoto Yukiko

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    Grant amount:\4030000 ( Direct Cost: \3100000 、 Indirect Cost:\930000 )

    Seventeen schizophrenia patients and 18 healthy controls were presented with a point-light walker as biological motion (BM) stimuli. We investigated the neural basis of impaired BM processing using MRI in respect to attention deficits by eye tracker. Voxel-based morphometry was performed to evaluate the relationship between BM perception and gray matter volume. It was suggested that alteration in the temporo-parietal junction might be associated with inefficient attentional strategy, whereas dysfunctional anterior superior temporal sulcus might be correlated with deficit in higher order BM processing per se. Several cognitive levels as well as corresponding brain areas are possibly involved in the manifestation of social cognitive deficits in schizophrenia.

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Other research activities

  • 「統合失調症の脳における「意味関係の乱れ」を発見」 ― AI技術の応用により脳活動から思考障害のメカニズムに迫る ―

    2022.12

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    Schizophrenia Bulletin

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  • 「COVID-19診療に従事する医療関係者の直面しているストレスに関連する危険因子を同定」― 平常時とは反対に「同居者の存在」が葛藤に ―

    2021.3

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    Journal of Psychiatric Research

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