Updated on 2025/07/04

写真a

 
Iwadate Reiko
 
Affiliation
Faculty of Medicine, Department of Chemistry, Senior Assistant Professor
Title
Senior Assistant Professor
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Degree

  • Ph.D ( 2015.3   Keio University )

Research Areas

  • Life Science / Molecular biology

  • Life Science / Tumor biology

  • Life Science / Pharmaceutical hygiene and biochemistry

Education

  • Keio University   Graduate School of Medicine

    2011.4 - 2015.3

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  • Keio University   Graduate School of Pharmaceutical Sciences

    2009.4 - 2011.3

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  • Josai International University   Faculty of Pharmaceutical Sciences

    2005.4 - 2009.3

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Research History

  • Nippon Medical School   Department of Chemistry   Assistant professor

    2025.4

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    Country:Japan

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  • Josai University   Faculty of Pharmaceutical Sciences Department of Pharmaceutical Sciences   Assistant Professor

    2020.4 - 2025.3

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    Country:Japan

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  • Josai University   Faculty of Pharmaceutical Sciences   Research Associate

    2018.4 - 2020.3

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    Country:Japan

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  • Tokyo Medical and Dental University   Department of Molecular Cytogenetics, Medical Research Institute

    2011.4 - 2015.3

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Professional Memberships

  • The Pharmaceutical Society of Japan

    2019

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  • Japan Society of Obstetrics and Gynecology

    2011

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  • The Japanese Cancer Association

    2011

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  • The Japanese Society of Clinical Pharmacology and Therapeutics

    2011

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Papers

  • Three-dimensional correlation between maxillary movement and nasolabial soft tissue changes immediately and 1 year following Le Fort I osteotomy in skeletal class III patients: new insights into nasolabial changes after surgery

    Shinsuke Yamamoto, Reiko Iwadate, Keigo Maeda, Naoki Taniike

    Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology   2025.7

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ajoms.2025.06.016

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  • Indications and limitations of CAD/CAM splints in Le Fort I osteotomy Reviewed

    S. Yamamoto, R. Iwadate, K. Maeda, N. Taniike

    International Journal of Oral and Maxillofacial Surgery   2025.4

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ijom.2025.04.007

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  • Postoperative maxillary stability after Le Fort I osteotomy using a u-HA/PLLA system: three-dimensional analysis by surface superimposition based on virtual Le Fort I osteotomy. Reviewed International journal

    S Yamamoto, R Iwadate, K Maeda, N Taniike

    International journal of oral and maxillofacial surgery   54 ( 4 )   337 - 345   2025.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    The postoperative stability achieved with Le Fort I osteotomy (LFI) using bioabsorbable systems remains controversial. A new method - multipoint measurement method - was devised for detailed three-dimensional examination of postoperative stability following LFI, and the stability after LFI when using SuperFIXSORB-MX made of u-HA/PLLA was investigated. Thirty-one patients who underwent LFI using SuperFIXSORB-MX were evaluated retrospectively. The patients were divided into four malocclusion types: open bite, mandibular retrognathia, mandibular protrusion, and facial asymmetry. Seven maxillary reference points were measured three-dimensionally using computed tomography scans obtained preoperatively (T0), 4 days post-surgery (T1), and 1 year post-surgery (T2). Surgical changes (T1-T0) and the postoperative discrepancy (T2-T1) of the maxilla were analysed to evaluate postoperative stability by surface superimposition of the virtual LFI segments. Postoperative discrepancy was the largest for the facial asymmetry type, ranging from 0.75 ± 0.45 mm to 0.98 ± 0.52 mm in three-dimensional distance (minimum to maximum mean ± standard deviation values for the individual reference points). The relapse at U1 was 16% in the transverse axis, and the anterior nasal spine moved further upward by 17% of the amount of movement of the maxilla. Fixation with SuperFIXSORB-MX was considered to be within clinically acceptable limits.

    DOI: 10.1016/j.ijom.2024.09.001

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  • Effects of Phenobarbital and Dosing Time on The Plasma Concentration and Pharmacological Activity of Tadalafil in Mice

    Hiroshi Kawai, Naoki Takeda, Naoko Kojima, Reiko Iwadate, Naomi Kudo, Atsushi Mitsumoto

    BPB Reports   2025

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1248/bpbreports.8.3_86

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  • Urinary Bile Acid Shows Diurnal Fluctuation and Phase Shift with Daytime-Restricted Feeding in Rats

    Hiroshi Kawai, Ai Kurokawa, Takuya Ishibashi, Reiko Iwadate, Naomi Kudo, Yoichi Kawashima, Atsushi Mitsumoto

    BPB Reports   2020

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1248/bpbreports.3.2_60

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  • Antidepressants with different mechanisms of action show different chronopharmacological profiles in the tail suspension test in mice. Reviewed International journal

    Hiroshi Kawai, Reiko Iwadate, Takuya Ishibashi, Naomi Kudo, Yoichi Kawashima, Atsushi Mitsumoto

    Chronobiology international   36 ( 9 )   1194 - 1207   2019.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    The circadian system regulates sleep/wake cycles, metabolism, mood, and other functions. It also influences medication efficacy. In this study, we studied the chronopharmacological profiles of antidepressants with various modes of action. We also investigated the effects of dosing time on the pharmacological activity of several antidepressants acting on serotonergic, noradrenergic, and/or dopaminergic neurons. C57BL/6 mice were intraperitoneally administered fluoxetine, imipramine, venlafaxine, or bupropion at 08:00 h (morning), 14:00 h (mid-day), 20:00 h (evening), or 02:00 h (mid-night). Antidepressant activity was evaluated by the tail suspension test. All antidepressants reduced immobility, and their activities varied according to the dosing time. Fluoxetine and imipramine induced relatively strong rhythms with high amplitudes. Their maximal effects were observed in the morning and evening, respectively. Venlafaxine and bupropion induced weak rhythms with maximal effects in the evening and dawn, respectively. These results suggest that the antidepressant activity is associated with circadian fluctuation, and antidepressants with different modes of action have different chronopharmacological profiles. They affect locomotor activity in animals placed in novel (unfamiliar) environments. Fluoxetine, imipramine, and venlafaxine reduced locomotor activity, whereas bupropion increased it. The effects on locomotor activity also vary with circadian rhythm, and the tested drugs showed a maximal effect during the light phase. The peak time was different from that in TST. Plasma and brain levels of all drugs were slightly higher in the morning than in the evening. The dosing time dependency of the antidepressant activity did not correlate with the sedative/stimulatory activity or tissue drug level. Therefore, these latter two factors may have only a small impact on circadian antidepressant activity fluctuations. The relative activity of the serotonergic, noradrenergic, and dopaminergic systems may determine the chronopharmacological profiles of each drug. These results suggest the possibility that drug therapy be optimized by considering the dosing time when the antidepressant activity is high and other pharmacological activities leading to adverse effects are low. Further studies using animal models of depression and in clinical settings are necessary to confirm the effects of dosing time on depressed subjects.

    DOI: 10.1080/07420528.2019.1625360

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  • The Efficacy of a Mattress Type Sleep Measuring Device in Analyzing Sleep in Healthy University Students: Comparison with Actigraphy

    Hiroshi Kawai, Yutaro Togashi, Takuya Ishibashi, Reiko Iwadate, Atsushi Mitsumoto

    BPB Reports   2019

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1248/bpbreports.2.6_125

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  • High Expression of p62 Protein Is Associated with Poor Prognosis and Aggressive Phenotypes in Endometrial Cancer Reviewed

    Reiko Iwadate, Jun Inoue, Hitoshi Tsuda, Masashi Takano, Kenichi Furuya, Akira Hirasawa, Daisuke Aoki, Johji Inazawa

    AMERICAN JOURNAL OF PATHOLOGY   185 ( 9 )   2523 - 2533   2015.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ajpath.2015.05.008

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  • High Expression of SQSTM1/p62 Protein Is Associated with Poor Prognosis in Epithelial Ovarian Cancer Reviewed

    Reiko Iwadate, Jun Inoue, Hitoshi Tsuda, Masashi Takano, Kenichi Furuya, Akira Hirasawa, Daisuke Aoki, Johji Inazawa

    ACTA HISTOCHEMICA ET CYTOCHEMICA   47 ( 6 )   295 - 301   2014

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1267/ahc.14048

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  • Impairment of heme biosynthesis induces short circadian period in body temperature rhythms in mice Reviewed

    Reiko Iwadate, Yoko Satoh, Yukino Watanabe, Hiroshi Kawai, Naomi Kudo, Yoichi Kawashima, Tadahiko Mashino, Atsushi Mitsumoto

    AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY   303 ( 1 )   R8 - R18   2012.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1152/ajpregu.00019.2011

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  • Manifestation of psychiatric behaviors in a mouse model of griseofulvin-induced hepatic porphyria Reviewed

    Yoko Satoh, Reiko Iwadate, Yukino Watanabe, Hiroshi Kawai, Naomi Kudo, Yoichi Kawashima, Atsushi Mitsumoto

    JOURNAL OF TOXICOLOGICAL SCIENCES   33 ( 5 )   599 - 608   2008.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2131/jts.33.599

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Misc.

  • p62/SQSTM1タンパク質の高発現は子宮体癌の悪性形質および不良な予後と相関する(High expression level of p62/SQSTM1 protein correlate with aggressive phenotype and poor prognosis in endometrial cancer)

    岩舘 怜子, 井上 純, 津田 均, 平沢 晃, 青木 大輔, 稲澤 譲治

    日本癌学会総会記事   73回   J - 1004   2014.9

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  • オートファジー障害を持つ癌細胞における化合物スクリーニング(Screening of chemical compounds for autophagy-deficient cancer cells)

    岩舘 怜子, 井上 純, 青木 大輔, 稲澤 譲治

    日本癌学会総会記事   72回   192 - 192   2013.10

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Presentations

  • Diurnal fluctuation of hypoglycemic effect of antidiabetic agents, glibenclamide andglimepiride, in mice

    Hiroshi Kawai, Reiko Iwadate

    第98回日本薬理学会  2025.3 

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    Event date: 2025.3

    Presentation type:Poster presentation  

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  • Relationships between sleep quality and diurnal glucose rhythm in healthy university students

    2024.3 

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    Event date: 2024.3

    Presentation type:Poster presentation  

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  • Aberrant photoperiod affects hyperglycemia induced;by corticosterone in mice

    2023.9 

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    Event date: 2023.9

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  • 若年成人における睡眠習慣と血糖日内変動の解析

    河合 洋, 原田 真季, 岩舘 怜子

    日本薬学会第143年会  2023.3 

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    Event date: 2023.3

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  • タダラフィルの血中動態に及ぼすフェノバルビタールおよび投与時刻の影響

    河合 洋, 武田 直樹, 兒嶋 眞子, 岩舘 怜子

    日本薬学会第142年会  2022.3 

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    Event date: 2022.3

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  • コルチコステロン投与マウスにおいて糖尿病発症より早期に生じる概日リズム異常

    岩舘 怜子, 河合 洋

    日本薬学会第141年会  2021.3 

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    Event date: 2021.3

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  • SGLT2阻害薬empagliflozinのケトン体 増加効果は夜間投与において大きい

    橋本 直人, 岩舘 怜子, 河合 洋

    日本薬学会第141年会  2021.3 

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    Event date: 2021.3

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  • コルチコステロン投与マウスにおける糖尿病病態への日照条件の影響

    岩舘 怜子, 河合 洋

    日本薬学会第140年会  2020.3 

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    Event date: 2020.3

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  • Circadian fluctuation of pharmacological activity of antidepressants in mice

    河合 洋, 岩舘 怜子, 石橋 拓也, 光本 篤史

    第26回日本時間生物学会学術大会  2019.10 

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    Event date: 2019.10

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  • High expression level of p62/SQSTM1 protein correlate with aggressive phenotype and poor prognosis in endometrial cancer

    岩舘 怜子, 井上 純, 津田 均, 平沢 晃, 青木 大輔, 稲澤 譲治

    第73回日本癌学会学術総会  2014.9 

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    Event date: 2014.9

    Presentation type:Oral presentation (general)  

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  • Screening of chemical compounds for autophagy-deficient cancer cells

    2013.10 

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    Event date: 2013.10

    Presentation type:Oral presentation (general)  

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  • 子宮体癌においてDNA過剰メチル化により発現抑制される癌抑制遺伝子型microRNA miR-152の同定

    鶴田 智彦, 平沢 晃, 進 伸幸, 岩舘 怜子, 高橋 峰夫, 青木 大輔, 吉村 泰典

    第64回日本産科婦人科学会学術講演会  2012.4 

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    Event date: 2012.4

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  • ヘム代謝異常マウスは短周期の概日リズムを示す

    岩舘 怜子, 佐藤 陽子, 河合 洋, 増野 匡彦, 光本 篤史

    第17回日本時間生物学会学術大会  2010.11 

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    Event date: 2010.11

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