Updated on 2024/06/07

写真a

 
Gangi Mie
 
Affiliation
Faculty of Medicine, Department of Physiology, Assistant Professor
Title
Assistant Professor
External link

Research Areas

  • Life Science / Physiology

Research History

Papers

  • ON and OFF starburst amacrine cells are controlled by distinct cholinergic pathways. International journal

    Mie Gangi, Takuma Maruyama, Toshiyuki Ishii, Makoto Kaneda

    The Journal of general physiology   156 ( 8 )   2024.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    Cholinergic signaling in the retina is mediated by acetylcholine (ACh) released from starburst amacrine cells (SACs), which are key neurons for motion detection. SACs comprise ON and OFF subtypes, which morphologically show mirror symmetry to each other. Although many physiological studies on SACs have targeted ON cells only, the synaptic computation of ON and OFF SACs is assumed to be similar. Recent studies demonstrated that gene expression patterns and receptor types differed between ON and OFF SACs, suggesting differences in their functions. Here, we compared cholinergic signaling pathways between ON and OFF SACs in the mouse retina using the patch clamp technique. The application of ACh increased GABAergic feedback, observed as postsynaptic currents to SACs, in both ON and OFF SACs; however, the mode of GABAergic feedback differed. Nicotinic receptors mediated GABAergic feedback in both ON and OFF SACs, while muscarinic receptors mediated GABAergic feedback in ON SACs only in adults. Neither tetrodotoxin, which blocked action potentials, nor LY354740, which blocked neurotransmitter release from SACs, eliminated ACh-induced GABAergic feedback in SACs. These results suggest that ACh-induced GABAergic feedback in ON and OFF SACs is regulated by different feedback mechanisms in adults and mediated by non-spiking amacrine cells other than SACs.

    DOI: 10.1085/jgp.202413550

    PubMed

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  • The C‐terminal domain is required for mGluR6 cell‐surface localization

    Atsushi Shimohata, Dilip Rai, Takumi Akagi, Toshiyuki Ishii, Mie Gangi, Takuma Maruyama, Yuko Wada‐Kiyama, Ikuo Ogiwara, Makoto Kaneda

    The FASEB Journal   35 ( S1 )   2021.5

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    Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    DOI: 10.1096/fasebj.2021.35.s1.01591

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  • Involvement of the C‐terminal domain in cell surface localization and G‐protein coupling of mGluR6 Reviewed

    Dilip Rai, Takumi Akagi, Atsushi Shimohata, Toshiyuki Ishii, Mie Gangi, Takuma Maruyama, Yuko Wada‐Kiyama, Ikuo Ogiwara, Makoto Kaneda

    Journal of Neurochemistry   158 ( 4 )   837 - 848   2020.10

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    Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    DOI: 10.1111/jnc.15217

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  • Synchronized retinal oscillations encode essential information for escape behavior in frogs Reviewed

    H Ishikane, M Gangi, S Honda, M Tachibana

    NATURE NEUROSCIENCE   8 ( 8 )   1087 - 1095   2005.8

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:NATURE PUBLISHING GROUP  

    Synchronized oscillatory activity is generated among visual neurons in a manner that depends on certain key features of visual stimulation. Although this activity may be important for perceptual integration, its functional significance has yet to be explained. Here we find a very strong correlation between synchronized oscillatory activity in a class of frog retinal ganglion cells ( dimming detectors) and a well-known escape response, as shown by behavioral tests and multi-electrode recordings from isolated retinas. Escape behavior elicited by an expanding dark spot was suppressed and potentiated by intraocular injection of GABA(A) receptor and GABA(C) receptor antagonists, respectively. Changes in escape behavior correlated with antagonist-evoked changes in synchronized oscillatory activity but not with changes in the discharge rate of dimming detectors. These antagonists did not affect the expanding dark spot - induced responses in retinal ganglion cells other than dimming detectors. Thus, synchronized oscillations in the retina are likely to encode escape-related information in frogs.

    DOI: 10.1038/nn1497

    Web of Science

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  • Triggering of escape behavior by oscillatory synchronized discharges of retinal ganglion cells in frogs. Reviewed

    Mie GangiShoko Honda, Mie Gangi, Yasuhiro Horiuchi, Hiroshi Ishikane, Masao Tachibana

    The Japanese Journal of Psychonomic Science   24 ( 1 )   107 - 108   2005

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:The Japanese Psychonomic Society  

    In the retinas of frogs synchronized discharges accompanied by γ-range oscillations (the oscillatory synchronization, OS) are generated among OFF-sustained ganglion cells (dimming detectors) in response to a dimming stimulus. We have already shown that an expanding dark spot generates the retinal OS and elicits escape behavior, which is abolished when the OS is suppressed by a GABA_A receptor antagonist. Recently we observed that a GABA_C receptor antagonist, (1,2,5,6-tetrahydropyridine-4-yl) methylphosphinic acid (TPMPA), enhanced the oscillatory activity of dimming detectors. In the present study, we investigated how OS and escape behavior were modulated when TPMPA was applied to the retina. An intraocular injection of TPMPA potentiated escape behavior. Moreover, multi-electrode recordings from isolated retinas revealed that the OS was significantly enhanced by TPMPA. On the other hand, TPMPA did not affect the response properties of other ganglion cells which were not dimming detectors. Furthermore, modulation of the retinal OS by the GABA receptor antagonists was closely related to the changes in escape behavior. Consequently, we conclude that the OS may encode escape-related information.

    DOI: 10.14947/psychono.KJ00004348788

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  • Pharmacological suppression of oscillatory synchronized discharges in retinal ganglion cells inhibits escape behavior of the frog. Reviewed

    Mie Gangi, Yasuhiro Horiuchi, Shoko Honda, Hiroshi Ishikane, Masao Tachibana

    The Japanese Journal of Psychonomic Science   23 ( 1 )   109 - 110   2004

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:The Japanese Psychonomic Society  

    In the frog retina OFF-sustained type ganglion cells (dimming detectors) generate oscillatory synchronized discharges with a light which is dimming. To elucidate the function of the oscillatory synchronization (OS) in the retina we performed behavioral experiments and multielectrode recordings from dimming detectors. Frogs exhibited an escape behavior when an expanding dark spot was presented on a computer monitor. The probability of the escape behavior was higher as the final size of the expanding dark spot was increased. Multi-electrode recordings from the isolated retina revealed that the OS was enhanced as the final size of the expanding dark spot was increased. The OS could be blocked when the isolated retina was superfused with bicuculline, a GABA_A receptor blocker. Injection of bicuculline into the eyes of the frog significantly suppressed the escape behavior but did not affect the optokinetic responses to a drifting grating. We conclude that the OS of dimming detectors in the retina is essential for triggering the escape behavior.

    DOI: 10.14947/psychono.KJ00004414533

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  • Neural mechanisms of synchronous oscillations in retinal ganglion cells Reviewed

    M Tachibana, H Ishikane, M Gangi, Arai, I, T Asaka, JL Du

    NEURAL BASIS OF EARLY VISION   11   59 - 60   2003

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    Language:English   Publishing type:Research paper (international conference proceedings)   Publisher:SPRINGER-VERLAG TOKYO  

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  • Synchronous Oscillations in Frog Retinal Ganglion Cells. Invited Reviewed

    Hiroshi Ishikane, Mie Gangi, Masao Tachibana

    The Japanese Journal of Psychonomic Science   21 ( 1 )   47 - 48   2002

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:The Japanese Psychonomic Society  

    To investigate how visual information is coded by cell populations, we simultaneously recorded light-evoked spike discharges from multiple OFF-sustained type ganglion cells (the dimming detectors) of the frog retina using a planar multi-electrode array. Auto- and cross-correlation analyses were performed to evaluate temporal properties of the spike trains. With full-field, sinusoidally modulated diffuse illumination, cross-correlation analysis revealed the presence of long-range synchronous oscillations. The strength of the synchronous oscillations depended on the spatial properties of the light stimulus, which extended far beyond the "classical" receptive field that is defined by the spike discharge rate. These results suggest that synchronous oscillations may encode global features of visual stimuli and play a key role in perceptual integration.

    DOI: 10.14947/psychono.KJ00004414131

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Books

  • 基礎心理学実験法ハンドブック

    石金浩史, 雁木美衣( Role: Joint author剥離網膜標本を用いた実験)

    朝倉書店  2018.6 

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Misc.

  • 電位依存性ナトリウムチャネルNav1.1と線維芽細胞増殖因子相同因子の相互作用

    荻原郁夫, 尹成珠, 下畑充志, 雁木美衣, 金田誠

    日本神経化学会大会抄録集(Web)   65th   2022

  • Identification of amacrine cells involved in motion detection in the rat retina

    Mie Gangi, Yoshiyuki Yamazaki, Teiko Kuroda, Michiko Imanishi, Masao Tachibana, Masahiko Takada

    NEUROSCIENCE RESEARCH   65   S204 - S205   2009

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    Language:English   Publishing type:Research paper, summary (international conference)   Publisher:ELSEVIER IRELAND LTD  

    DOI: 10.1016/j.neures.2009.09.1123

    Web of Science

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  • FUNCTIONAL SIGNIFICANCE OF GAP JUNCTIONS AMONG RETINAL BIPOLAR CELLS

    Masao Tachibana, Itaru Arai, Masashi Tanaka, Mie Gangi

    JOURNAL OF PHYSIOLOGICAL SCIENCES   59   32 - 32   2009

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    Language:English   Publishing type:Research paper, summary (international conference)   Publisher:SPRINGER TOKYO  

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  • Localization of Kv3 channels in the retina

    Mie Gangi, Michiko Imanishi, Teiko Kuroda, Masao Tachibana, Masahiko Takada

    NEUROSCIENCE RESEARCH   55   S146 - S146   2006

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    Language:English   Publishing type:Research paper, summary (international conference)   Publisher:ELSEVIER IRELAND LTD  

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  • 網膜神経節細胞群の周期的同期発火による視覚誘発性逃避行動の誘発(日本基礎心理学会第23回大会,大会発表要旨)

    本田祥子, 雁木美衣, 堀内靖大, 石金浩史, 立花政夫

    基礎心理学研究   23 ( 2 )   220 - 220   2005.3

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    Language:Japanese   Publisher:日本基礎心理学会  

    DOI: 10.14947/psychono.KJ00004414561

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  • カエル網膜における同期的周期的発火の阻害が視覚誘発性逃避行動に与える影響(日本基礎心理学会第22回大会,大会発表要旨)

    雁木美衣, 堀内靖大, 本田祥子, 石金浩史, 立花政夫

    基礎心理学研究   22 ( 2 )   227 - 228   2004.3

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    Language:Japanese   Publisher:日本基礎心理学会  

    DOI: 10.14947/psychono.KJ00004414444

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  • Neural mechanisms of synchronous oscillations in retinal ganglion cells

    TACHIBANA Masao, ISHIKANE Hiroshi, GANGI Mie, ARAI Itaru, ASAKA Tomomitsu, DU Jiulin

    51   31 - 31   2002.8

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    Language:English  

    CiNii Books

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  • カエル網膜ディミング検出器における周期的発火の生起と刺激依存性(発表要旨,日本動物心理学会第61回大会・日本基礎心理学会第20回大会合同大会)

    石金浩史, 雁木美衣, 立花政夫

    基礎心理学研究   20 ( 2 )   224 - 225   2002.3

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    Language:Japanese   Publisher:日本基礎心理学会  

    DOI: 10.14947/psychono.KJ00004414053

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  • マウス網膜神経節細胞における運動方向選択性の形成機構(研究発表D,VII.第19回大会発表要旨)

    石金浩史, 雁木美衣, 立花政夫

    基礎心理学研究   19 ( 2 )   142 - 142   2001.3

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    Language:Japanese   Publisher:日本基礎心理学会  

    DOI: 10.14947/psychono.KJ00004413920

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Awards

  • 第23回大会優秀発表賞

    2005.12   日本基礎心理学会   網膜神経節細胞群の周期的同期発火による視覚誘発性逃避行動の誘発

    本田祥子, 雁木美衣, 堀内靖大, 石金浩史

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  • 第22回大会優秀発表賞

    2004.11   日本基礎心理学会   カエル網膜における同期的周期的発火の阻害が視覚誘発性逃避行動に与える影響

    雁木美衣, 石金浩史

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  • 第20回大会優秀発表賞

    2002.11   日本基礎心理学会   カエル網膜ディミング検出器における周期的発火の生起と刺激依存性

    石金浩史, 雁木美衣

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Research Projects

  • 網膜における運動検出のモデルの再構築

    Grant number:22K18162  2022.4 - 2027.3

    日本学術振興会  科学研究費助成事業  若手研究

    雁木 美衣

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    Grant amount:\4550000 ( Direct Cost: \3500000 、 Indirect Cost:\1050000 )

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