掲載種別：研究論文（学術雑誌）   出版者・発行元：Wiley  

DOI： 10.1096/fasebj.2021.35.s1.01591

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掲載種別：研究論文（学術雑誌）   出版者・発行元：Wiley  

DOI： 10.1111/jnc.15217

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：NATURE PUBLISHING GROUP  

Synchronized oscillatory activity is generated among visual neurons in a manner that depends on certain key features of visual stimulation. Although this activity may be important for perceptual integration, its functional significance has yet to be explained. Here we find a very strong correlation between synchronized oscillatory activity in a class of frog retinal ganglion cells ( dimming detectors) and a well-known escape response, as shown by behavioral tests and multi-electrode recordings from isolated retinas. Escape behavior elicited by an expanding dark spot was suppressed and potentiated by intraocular injection of GABA(A) receptor and GABA(C) receptor antagonists, respectively. Changes in escape behavior correlated with antagonist-evoked changes in synchronized oscillatory activity but not with changes in the discharge rate of dimming detectors. These antagonists did not affect the expanding dark spot - induced responses in retinal ganglion cells other than dimming detectors. Thus, synchronized oscillations in the retina are likely to encode escape-related information in frogs.

DOI： 10.1038/nn1497

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：日本基礎心理学会  

In the retinas of frogs synchronized discharges accompanied by γ-range oscillations (the oscillatory synchronization, OS) are generated among OFF-sustained ganglion cells (dimming detectors) in response to a dimming stimulus. We have already shown that an expanding dark spot generates the retinal OS and elicits escape behavior, which is abolished when the OS is suppressed by a GABA_A receptor antagonist. Recently we observed that a GABA_C receptor antagonist, (1,2,5,6-tetrahydropyridine-4-yl) methylphosphinic acid (TPMPA), enhanced the oscillatory activity of dimming detectors. In the present study, we investigated how OS and escape behavior were modulated when TPMPA was applied to the retina. An intraocular injection of TPMPA potentiated escape behavior. Moreover, multi-electrode recordings from isolated retinas revealed that the OS was significantly enhanced by TPMPA. On the other hand, TPMPA did not affect the response properties of other ganglion cells which were not dimming detectors. Furthermore, modulation of the retinal OS by the GABA receptor antagonists was closely related to the changes in escape behavior. Consequently, we conclude that the OS may encode escape-related information.

DOI： 10.14947/psychono.KJ00004348788

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：日本基礎心理学会  

In the frog retina OFF-sustained type ganglion cells (dimming detectors) generate oscillatory synchronized discharges with a light which is dimming. To elucidate the function of the oscillatory synchronization (OS) in the retina we performed behavioral experiments and multielectrode recordings from dimming detectors. Frogs exhibited an escape behavior when an expanding dark spot was presented on a computer monitor. The probability of the escape behavior was higher as the final size of the expanding dark spot was increased. Multi-electrode recordings from the isolated retina revealed that the OS was enhanced as the final size of the expanding dark spot was increased. The OS could be blocked when the isolated retina was superfused with bicuculline, a GABA_A receptor blocker. Injection of bicuculline into the eyes of the frog significantly suppressed the escape behavior but did not affect the optokinetic responses to a drifting grating. We conclude that the OS of dimming detectors in the retina is essential for triggering the escape behavior.

DOI： 10.14947/psychono.KJ00004414533

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J-GLOBAL

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記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）   出版者・発行元：ELSEVIER IRELAND LTD  

DOI： 10.1016/j.neures.2009.09.1123

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記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）   出版者・発行元：SPRINGER TOKYO  

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記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）   出版者・発行元：ELSEVIER IRELAND LTD  

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記述言語：日本語   出版者・発行元：日本基礎心理学会  

DOI： 10.14947/psychono.KJ00004414561

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