Updated on 2024/04/13

写真a

 
Ino Yuka
 
Affiliation
Nippon Medical School Hospital, Department of Anesthesiology and Pain Medicine, Clinical Assistant Professor
Title
Clinical Assistant Professor
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Degree

  • 医学博士（日本医科大学）

Papers

  • TSLP in DRG neurons causes the development of neuropathic pain through T cells. International journal

    Yuka Ino, Motoyo Maruyama, Masumi Shimizu, Rimpei Morita, Atsuhiro Sakamoto, Hidenori Suzuki, Atsushi Sakai

    Journal of neuroinflammation   20 ( 1 )   200 - 200   2023.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: Peripheral nerve injury to dorsal root ganglion (DRG) neurons develops intractable neuropathic pain via induction of neuroinflammation. However, neuropathic pain is rare in the early life of rodents. Here, we aimed to identify a novel therapeutic target for neuropathic pain in adults by comprehensively analyzing the difference of gene expression changes between infant and adult rats after nerve injury. METHODS: A neuropathic pain model was produced in neonatal and young adult rats by spared nerve injury. Nerve injury-induced gene expression changes in the dorsal root ganglion (DRG) were examined using RNA sequencing. Thymic stromal lymphopoietin (TSLP) and its siRNA were intrathecally injected. T cells were examined using immunofluorescence and were reduced by systemic administration of FTY720. RESULTS: Differences in changes in the transcriptome in injured DRG between infant and adult rats were most associated with immunological functions. Notably, TSLP was markedly upregulated in DRG neurons in adult rats, but not in infant rats. TSLP caused mechanical allodynia in adult rats, whereas TSLP knockdown suppressed the development of neuropathic pain. TSLP promoted the infiltration of T cells into the injured DRG and organized the expressions of multiple factors that regulate T cells. Accordingly, TSLP caused mechanical allodynia through T cells in the DRG. CONCLUSION: This study demonstrated that TSLP is causally involved in the development of neuropathic pain through T cell recruitment.

    DOI： 10.1186/s12974-023-02882-y

    PubMed

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  • Skin burn related to pulse oximetry during photodynamic therapy using talaporfin sodium. Reviewed International journal

    Yuka Ino, Midori Nakashima, Tomonori Morita, Yoko Hori, Hiroaki Kishikawa, Nobutoshi Hagiwara, Takeshi Matsutani, Tsutomu Nomura, Atsuhiro Sakamoto

    JA clinical reports   4 ( 1 )   69 - 69   2018.9

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Misc.

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Research Projects

  • Novel therapeutic target based on neonatal resistance to neuropathic pain

    Grant number：16K10986  2016.4 - 2019.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    Sakai Atsushi, Maruyama Motoyo, Ino Yuka

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    Grant amount：\4680000 （ Direct Cost: \3600000 、 Indirect Cost：\1080000 ）

    Traumatic nerve injury inducing neuropathic pain in adult animals were produced in neonatal and young adult rats. Comprehensive gene expression changes in nerve-injured neonatal and young adult rats were examined using RNA sequence. A number of genes that showed differential expression changes between these rats were first identified in the dorsal root ganglia, which detects peripheral sensory stimuli. Many of these genes had many inflammation- and/or immune-related functions and therefore is considered a novel therapeutic target for neuropathic pain.

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