Updated on 2025/10/28

写真a

 
Hanako Tajima
 
Affiliation
Musashikosugi Hospital, Department of Pediatrics, Professor
Title
Professor
External link

Papers

  • Accurate Diagnosis of Familial Mediterranean Fever Improved Quality of Life for a Patient and Her Family: A Case Report.

    Mami Kurihara, Toru Igarashi, Ryu Ishii, Hanako Tajima, Jun Hayakawa, Makoto Migita

    Journal of Nippon Medical School = Nippon Ika Daigaku zasshi   2025.6

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    Language：English   Publishing type：Research paper (scientific journal)  

    Periodic fever syndrome is diagnosed on the basis of duration of fever, associated symptoms, and blood and genetic test results. During a 6-month period, a 3-year-old girl experienced monthly fever (39°C) episodes persisting 5 to 12 days and two episodes of ankle arthralgia and skin rash during fever. No abdominal or chest pain was noted. Blood tests performed at the time of fever revealed elevated CRP levels and blood sedimentation rates. Urinalysis and bone marrow examination results were unremarkable. Genetic testing for hereditary autoinflammatory disease syndromes showed E84K MEFV gene mutations. After diagnosing atypical familial Mediterranean fever, oral colchicine alleviated the febrile attacks and improved family quality of life. Fever, arthralgia, and skin rash disappeared after oral colchicine, which is effective for atypical familial Mediterranean fever. During the 6 months before the diagnosis, periodic fever disrupted the daily lives of the entire family. The patient was absent from nursery school during fever. The patient's illness affected her mother's health. The mother was concerned about her child's unknown fever, which resulted in depression and the need for psychiatric medication. Colchicine resolved the febrile episodes, and resolution of the patient's symptoms alleviated her mother's depression. This case shows that genetic testing for periodic fever syndrome can improve family quality of life.

    DOI： 10.1272/jnms.JNMS.2025_92-610

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  • A case of massive abnormal genital bleeding due to central precocious puberty complicated by polycystic ovary syndrome responding remarkably to GnRH antagonist treatment

    深井美佑, 市川智子, 奥田直史, 白石達典, 中尾仁彦, 豊島将文, 市川雅男, 鈴木俊治, 唐木英一, 田嶋華子, 伊藤保彦

    東京産科婦人科学会会誌   73 ( 3 )   663 - 668   2024.7

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    Language：Japanese  

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  • A case of Leber’s hereditary optic neuropathy differentiate from optic neuritis

    毛利玲於奈, 宮田康平, 栗原茉杏, 田嶋華子, 右田真, 小早川信一郎

    臨床眼科   78 ( 5 )   603 - 608   2024.5

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    Language：Japanese  

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  • A Case of X-Linked Agammaglobulinemia and COVID-19 in a Japanese Infant.

    Junya Sugihara, Mami Kurihara, Hikaru Takeshita, Hanako Tajima, Jun Hayakawa, Hidehiko Narazaki, Makoto Migita, Yasuhiko Itoh

    Journal of Nippon Medical School = Nippon Ika Daigaku zasshi   91 ( 6 )   574 - 578   2024

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    Language：English   Publishing type：Research paper (scientific journal)  

    An infant was diagnosed as having X-linked agammaglobulinemia (XLA) at age 3 months and was receiving immunoglobulin replacement therapy. He developed SARS-CoV-2 infection at age 7 months and was treated with intravenous immunoglobulin, remdesivir, and dexamethasone. His respiratory symptoms improved quickly, and the infection resolved. Viral disappearance was confirmed via PCR, and the result of a SARS-CoV-2 test was negative on day 67 of illness, as a result of antiviral therapy. Immunoglobulin administered to the patient did not contain anti-SARS-CoV-2 antibodies, and no seroconversion of anti-SARS-CoV-2 antibodies was observed after healing. These findings suggest that humoral immunity did not contribute to infection in our patient. Thus, the importance of cellular immunity against COVID-19 was confirmed. In the future, it is hoped that testing companies will be able to use the ELISPOT assay to check cellular immunity in order to confirm the effectiveness of vaccines and the history of infection.

    DOI： 10.1272/jnms.JNMS.2024_91-606

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  • Clinical management of diazoxide-unresponsive congenital hyperinsulinism: A single-center experience.

    Kei Takasawa, Ryosei Iemura, Ryuta Orimoto, Haruki Yamano, Shizuka Kirino, Eriko Adachi, Yoko Saito, Kurara Yamamoto, Nozomi Matsuda, Shigeru Takishima, Kumi Shuno, Hanako Tajima, Manabu Sugie, Yuki Mizuno, Akito Sutani, Kentaro Okamoto, Michiya Masue, Tomohiro Morio, Kenichi Kashimada

    Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology   33 ( 3 )   187 - 194   2024

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    The most common cause of persistent hypoglycemia in newborns and children is congenital hyperinsulinism (CHI). Remarkable advancements in diagnostic tools and treatments, including novel imaging and genetic techniques, and continuous subcutaneous octreotide administration, have improved the prognosis of diazoxide-unresponsive CHI; however, in clinical practice, some issues remain. Here, we report a case series consisting of four adenosine triphosphate-sensitive potassium-associated CHI cases, discuss the practical use of new international guidelines published in 2023, and suggest clinical issues associated with CHI management. Based on the clinical experience of two diffuse and two focal CHI cases, we employed an updated treatment strategy, including genetic diagnosis to determine treatment plans, careful catheter management, switching from octreotide to long-acting somatostatin, effective utilization of a continuous glucose monitoring (CGM) device, measures for feeding problems, and individualized and systematic developmental follow-up. Particularly, our cases suggest a safe method of switching from octreotide to lanreotide, elucidate the efficacy of home-based CGM monitoring, and indicate need for personalized support for feeding problems. Severe CHI is a rare and challenging disorder; thus, further accumulation of experience according to new treatment strategies is essential in generating high-quality evidence for the development and approval of new treatment options.

    DOI： 10.1297/cpe.2024-0004

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  • A Case of Recurrent Bacterial Meningitis in a Girl with Mondini Deformity

    小林光一, 早川潤, 佐野透美, 楊井瑛美, 竹下輝, 橋本康司, 田嶋華子, 五十嵐徹, 川上康彦, 右田真

    日本医科大学医学会雑誌   18 ( 3 )   299 - 303   2022.8

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  • A case of scurvy in autism spectrum disorder diagnosed by pathological anatomy

    竹下輝, 許田典男, 濱本光, 佐野透美, 田嶋華子, 早川潤, 右田真, 伊藤保彦

    日本小児科学会雑誌   126 ( 2 )   298 - 298   2022.2

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  • The Impact of Childhood Disease on Hospital Visiting: A Survey of Pediatricians.

    Hanako Tajima, Juri Ogawa, Izuru Nose, Ruby Pawankar, Miho Maeda, Morihisa Takarabe, Yutaka Momota, Miki Kakinuma

    Journal of Nippon Medical School = Nippon Ika Daigaku zasshi   89 ( 2 )   190 - 195   2021.9

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    BACKGROUND: The precise timing as to when caregivers should take their children to the hospital is crucial to ensure the health and safety of children. As children cannot make these decisions on their own, caregivers bear the core responsibility for the wellness of their children. The aim of this study was to determine how disease, disabilities and child behavior can influence when and how often caregivers take their children to the hospital. METHODS: A structured anonymous online survey was circulated to pediatricians in Japan. Pediatricians were queried about the patients' dispositions including their reactivity to pain, expression of pain, behavior at the hospital, and the timing of the visit. Patients were school-aged children and included those with autism spectrum disorder, attention-deficit hyperactivity disorder, Down syndrome, mental retardation, epilepsy, premature birth or allergies. RESULTS: Sixty-eight out of the 80 pediatricians responded to the survey (85% response rate). The results indicated that caregivers of the children with autism spectrum disorder, attention-deficit hyperactivity disorder and mental retardation took them to the hospital later than they should have essentially done. Conversely, children born prematurely or those with allergies were taken to the hospitals even when the symptoms were mild. CONCLUSIONS: Caregivers make decisions on when to visit the hospital based on the child's expression of pain and their behavior. The creation of guidelines to give appropriate guidance to caregivers as to when to visit the hospital is essential.

    DOI： 10.1272/jnms.JNMS.2022_89-214

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  • Growth Hormone Treatment at Nippon Medical School Chiba Hokusoh Hospital.

    Eri Kuramochi, Kazuya Mae, Yuuka Ohtomo, Reina Kamada, Hanako Sugano-Tajima, Takeshi Asano

    Journal of Nippon Medical School = Nippon Ika Daigaku zasshi   88 ( 1 )   39 - 44   2021.3

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    BACKGROUND: Since 2002, the Department of Pediatrics of Nippon Medical School Chiba Hokusoh Hospital has offered educational activities for children with short stature. We analyzed outcomes of growth hormone (GH) treatment for children with short stature treated at our hospital, particularly outcomes after the growth spurt. METHODS: We analyzed data from children aged 0 to 17 years who were treated with recombinant GH during the period from 2000 through 2016 and were followed for at least 2 years after the start of treatment. RESULTS: Among children with short stature, 85 had GH deficiency, 5 had Turner syndrome, 9 were small for gestational age, and 1 had Noonan syndrome. The outcomes of GH treatment was similar to those previously reported in Japan. Children with GH deficiency who started GH treatment before the growth spurt exhibited marked height catch-up until the second year, but the effect decreased after 3 years. The effect of treatment for GH deficiency that was started after the growth spurt continued for 4 to 5 years after the start of treatment. CONCLUSIONS: Improvement in height standard deviation score was similar when treatment was started before and after the growth spurt.

    DOI： 10.1272/jnms.JNMS.2021_88-103

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  • ペントラキシン3が高値を示した冠動脈瘤合併川崎病の1例

    高木 啓倫, 勝部 康弘, 赤尾 見春, 松井 亮介, 小林 光一, 長嶺 美和, 佐野 透美, 宮田 真貴子, 田辺 雄次郎, 田嶋 華子, 柳原 剛, 川上 康彦

    心臓   51 ( 12 )   1297 - 1303   2019.12

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    Language：Japanese   Publisher：(公財)日本心臓財団  

    症例は9ヵ月の男児。川崎病の主要症状6項目中4項目を認め、加えて、非常に不機嫌であること、BCG接種部位の発赤など川崎病を強く疑わせる臨床症状ならびに血液検査を考慮し川崎病を疑った。治療は第3病日より免疫グロブリン点滴静注(以下IVIG)療法を開始したが治療抵抗性のため、第5病日にIVIGを追加し、さらに第8病日にプレドニゾロンの追加を行い解熱した。心臓超音波検査では入院時には明らかな冠動脈病変(以下CAL)は認めなかったが、第9病日にはCAL合併が出現し、最大値は右冠動脈6.5mm(Zスコア10.44)、左冠動脈3.2mm(Zスコア4.28)となった。CALは発症1ヵ月時点でも改善を認められなかった。CRP値は3.66mg/dLと軽度の上昇に留まっていたが、PTX3値は63.7ng/mLと著しい高値を認めており、PTX3がIVIG不応例の予測ならびにCAL合併の予測に有用である可能性を示唆する症例と考え、過去のデータレビューとともに報告する。(著者抄録)

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    Other Link： https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2019&ichushi_jid=J00679&link_issn=&doc_id=20191213150013&doc_link_id=%2Fah2sinzd%2F2019%2F005112%2F015%2F1297-1303%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fah2sinzd%2F2019%2F005112%2F015%2F1297-1303%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

  • Obesity and adiposity indicators in asthma and allergic rhinitis in children. Reviewed International journal

    Tajima H, Pawankar R

    Current opinion in allergy and clinical immunology   19 ( 1 )   7 - 11   2019.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    PURPOSE OF REVIEW: The prevalence of obesity and allergic diseases, such as asthma and allergic rhinitis, is increasing worldwide not only in adults, but also in children. Experimental and clinical studies have demonstrated the effect of obesity not only on asthma, but also on other allergic diseases. RECENT FINDINGS: Allergic diseases, such as asthma and allergic rhinitis, are common chronic inflammatory diseases of the airways. Obesity is an increasingly common pediatric disease and is a risk factor for the development of asthma in that obese patients with asthma tend to have more severe asthma that does not respond well to standard asthma therapy. On the contrary, children with asthma maybe at a high risk of obesity, suggesting that the relationship of asthma and obesity seems to be interrelated. The role of obesity on the development of allergic rhinitis is not well defined, whereas allergic rhinitis may have an impact on obesity. SUMMARY: Childhood obesity is often considered to be less serious than obesity in adults because of the greater risk of complications in obese adults. In this review, we discuss the allergic confounders of obesity and the impact of allergic diseases on obesity. Proper control of the BMI within the normal range in children with allergic diseases is important.

    DOI： 10.1097/ACI.0000000000000504

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  • A case of anhidrotic ectodermal dysplasia presenting with pyrexia, atopic eczema, and food allergy. Reviewed International journal

    Suzuki T, Tajima H, Migita M, Pawankar R, Yanagihara T, Fujita A, Shima Y, Yanai E, Katsube Y

    Asia Pacific allergy   9 ( 1 )   e3   2019.1

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    Anhidrotic ectodermal dysplasia (AED) is a rare hereditary disorder with a triad of sparse hair, dental hypoplasia, and anhidrosis. Here we report a case of AED with food allergy and atopic eczema. The patient was a 11-month-old boy admitted to our hospital with pyrexia for 2 weeks. He presented with a history of dry skin, eczema, and food allergy to egg. On clinical examination, his body temperature was 38.8°C, with dry skin and eczema almost all over the body, sparse eyebrows, and scalp hair. Laboratory investigations and physical examination did not show any evidence of infection. Radioallergosorbent test was positive to egg yolk, egg white, ovomucoid, milk, house dust, and house dust mite. As the child did not sweat despite the high fever, we performed the sweat test which revealed a total lack of sweat glands. Genetic examination revealed a mutation of the EDA gene and he was diagnosed as AED. His pyrexia improved upon cooling with ice and fan. His mother had lost 8 teeth and her sweat test demonstrated low sweating, suggestive of her being a carrier of AED. Atopy and immune deficiencies have been shown to have a higher prevalence in patients with AED. Disruption of the skin barrier in patients with AED make them more prone to allergic diseases such as atopic eczema, bronchial asthma, allergic rhinitis and food allergy. Careful assessment of the familial history is essential to differentiate AED when examining patients with pyrexia of unknown origin and comorbid allergic diseases.

    DOI： 10.5415/apallergy.2019.9.e3

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  • Fulminant type 1 diabetes mellitus in Japanese children and adolescents: multi-institutional joint research of the Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes. Reviewed

    Shiga K, Urakami T, Suzuki J, Igarashi Y, Tajima H, Amemiya S, Sugihara S, Japanese Study, Group of, Insulin Therapy for Childhood, Adolescent Diabetes (JSGIT

    Endocrine journal   65 ( 8 )   795 - 803   2018.8

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    Fulminant type 1 diabetes mellitus (FT1DM) is a subtype of type 1 diabetes mellitus characterized by a remarkably abrupt onset. In Japan, FT1DM accounts for approximately 20% of acute-onset adult type 1 diabetes mellitus cases; however, reports of pediatric-onset FT1DM are rare. We aimed to determine the frequency and clinical characteristics of FT1DM in Japanese children and adolescents by conducting a 2-phase questionnaire survey among the members of the Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes (JSGIT) regarding their clinical experience with FT1DM. Responses were obtained from 54 of the 79 participating hospitals (68.4%). Of these, 8 hospitals managed a total of 15 pediatric patients with FT1DM (4 patients in each of 2 hospitals, 2 patients in 1 hospital, and 1 patient in each of 5 hospitals). The distribution of patient age was biphasic, with peaks in children younger than 5 years and older than 8 years of age. The clinical characteristics of FT1DM in this population (such as the duration from onset of symptoms to diagnosis, severity of symptoms, preceding flu-like episodes, and abnormal laboratory data) did not differ from those of patients with adult-onset FT1DM. The frequency of pediatric-onset FT1DM is low compared with that of adult-onset FT1DM. The genetic background and susceptibility patterns of pediatric patients with FT1DM may differ from those typical of adults with FT1DM, but both age groups share similar clinical characteristics.

    DOI： 10.1507/endocrj.EJ18-0029

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  • 小児期におけるALP基準値設定の有用性 小児期発症の低フォスファターゼ症を見逃さないために

    渡邉 淳, 田嶋 華子, 佐々木 元子, 青砥 泰二, 橋本 政子, 本間 博, 伊藤 保彦, 野間 桂, 中谷 中

    臨床病理   64 ( 補冊 )   4 - 14   2016.9

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    Language：Japanese   Publisher：日本臨床検査医学会  

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  • Cholelithiasis in a Patient with Type 2 Gaucher Disease Reviewed

    Makoto Migita, Sakae Kumasaka, Tae Matsumoto, Hanako Tajima, Takahiro Ueda, Atsuyuki Yamataka

    JOURNAL OF NIPPON MEDICAL SCHOOL   81 ( 1 )   40 - 42   2014.2

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：MEDICAL ASSOC NIPPON MEDICAL SCH  

    Gaucher disease is an autosomal recessively inherited lysosomal storage disease in which a deficiency of glucocerebrosidase is associated with the accumulation of glucocerebroside in reticuloendothelial cells. Clinically, 3 types of Gaucher disease have been defined on the basis of the presence or absence of neurological symptoms. The frequency of gallbladder involvement is reportedly greater in patients with type 1 Gaucher disease than in healthy persons. We report a case of recurrent cholelithiasis and liver failure in a patient with type 2 Gaucher disease who showed severe progressive neurological involvement.

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  • Clinical and immunophenotypic features of atypical complete DiGeorge syndrome Reviewed International journal

    Quang Van Vu, Taizo Wada, Tomoko Toma, Hanako Tajima, Miho Maeda, Risa Tanaka, Tsutomu Oh-ishi, Akihiro Yachie

    PEDIATRICS INTERNATIONAL   55 ( 1 )   2 - 6   2013.2

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：WILEY-BLACKWELL  

    Background DiGeorge syndrome is a congenital malformation characterized by variable defects of the thymus, heart and parathyroid glands. Athymic patients are classified as exhibiting complete DiGeorge syndrome. Some of these patients may also exhibit oligoclonal T-cell expansion, generalized rash and lymphadenopathy at some point after birth. This rare condition is known as atypical complete DiGeorge syndrome, resembles Omenn syndrome, and has not been fully characterized. Methods The clinical and immunophenotypic features of atypical complete DiGeorge syndrome were assessed in two affected Japanese infants. T-cell receptor (TCR) V repertoire was analyzed on flow cytometry and complementarity-determining region 3 spectratyping. Results Both patients had no detectable thymus tissue and profound T-cell lymphopenia soon after birth. Progressive increase of activated T cells, however, as well as eosinophilia, high serum IgE level, generalized rash, and lymphadenopathy were observed during early infancy. A highly restricted TCR V repertoire was demonstrated both in CD4+ and CD8+ T cells. Conclusions The Omenn syndrome-like manifestations might be associated with the oligoclonal proliferation of activated T cells. Analysis of the immunophenotype and TCR V repertoire is helpful to establish the early diagnosis of atypical complete DiGeorge syndrome.

    DOI： 10.1111/j.1442-200X.2012.03722.x

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  • Etanercept suppresses arteritis in a murine model of kawasaki disease: A comparative study involving different biological agents Reviewed International journal

    Ryuji Ohashi, Ryuji Fukazawa, Makoto Watanabe, Hanako Tajima, Noriko Nagi-Miura, Naohito Ohno, Shinichi Tsuchiya, Yuh Fukuda, Shunichi Ogawa, Yasuhiko Itoh

    International Journal of Vascular Medicine   2013   543141 - 543141   2013

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    Coronary arteritis, a complication of Kawasaki disease (KD), can be refractory to immunoglobulin (IVIG) treatment. To determine the most effective alternative therapy, we compared the efficacy of different agents in a mouse model of KD. Vasculitis was induced by injection of Candida albicans water-soluble fractions (CAWS) into a DBA/2 mouse, followed by administration of IVIG, etanercept, methylprednisolone (MP), and cyclosporine-A (CsA). At 2 and 4 weeks, the mice were sacrificed, and plasma cytokines and chemokines were measured. CAWS injection induced active inflammation in the aortic root and coronary arteries. At 2 weeks, the vasculitis was reduced only by etanercept, and this effect persisted for the subsequent 2 weeks. At 4 weeks, IVIG and CsA also attenuated the inflammation, but the effect of etanercept was more significant. MP exerted no apparent effect at 2 or 4 weeks. The suppressive effect exerted by etanercept on cytokines, such as interleukin- (IL-)6, IL-12, IL-13, and tumor necrosis factor-α (TNF-α), was more evident than that of others. The extent of arteritis correlated with the plasma TNF-α levels, suggesting a pivotal role of TNF-α in KD. In conclusion, etanercept was most effective in suppressing CAWS-induced vasculitis and can be a new therapeutic intervention for KD. © 2013 Ryuji Ohashi et al.

    DOI： 10.1155/2013/543141

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  • Successful Gene Therapy in Utero for Lethal Murine Hypophosphatasia Reviewed

    Hanako Sugano, Tae Matsumoto, Koichi Miyake, Atsushi Watanabe, Osamu Iijima, Makoto Migita, Sonoko Narisawa, Jose Luis Millan, Yoshitaka Fukunaga, Takashi Shimada

    HUMAN GENE THERAPY   23 ( 4 )   399 - 406   2012.4

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：MARY ANN LIEBERT INC  

    Hypophosphatasia (HPP), caused by mutations in the gene ALPL encoding tissue-nonspecific alkaline phosphatase (TNALP), is an inherited systemic skeletal disease characterized by mineralization defects of bones and teeth. The clinical severity of HPP varies widely, from a lethal perinatal form to mild odontohypophosphatasia showing only dental manifestations. HPP model mice (Akp2(-/-)) phenotypically mimic the severe infantile form of human HPP; they appear normal at birth but die by 2 weeks of age because of growth failure, hypomineralization, and epileptic seizures. In the present study, we investigated the feasibility of fetal gene therapy using the lethal HPP model mice. On day 15 of gestation, the fetuses of HPP model mice underwent transuterine intraperitoneal injection of adeno-associated virus serotype 9 (AAV9) expressing bone-targeted TNALP. Treated and delivered mice showed normal weight gain and seizure-free survival for at least 8 weeks. Vector sequence was detected in systemic organs including bone at 14 days of age. ALP activities in plasma and bone were consistently high. Enhanced mineralization was demonstrated on X-ray images of the chest and forepaw. Our data clearly demonstrate that systemic injection of AAV9 in utero is an effective strategy for the treatment of lethal HPP mice. Fetal gene therapy may be an important choice after prenatal diagnosis of life-threatening HPP.

    DOI： 10.1089/hum.2011.148

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  • Pichia anomala pneumonia in a patient with acute lymphoblastic leukemia on maintenance therapy Reviewed

    Hanako Sugano, Takahiro Ueda, Makoto Migita, Shigenao Mimura, Miho Maeda, Takashi Sugita, Yoshitaka Fukunaga

    LEUKEMIA & LYMPHOMA   51 ( 8 )   1574 - 1576   2010.8

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    Language：English   Publisher：TAYLOR & FRANCIS LTD  

    DOI： 10.3109/10428194.2010.488707

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  • Neurocutaneous melanosis with acute disseminated encephalomyelitis Reviewed

    Takeshi Asano, Hisamitsu Hamada, Yuko Takita, Makoto Watanabe, Hanako Sugano, Mari Sudoh, Miho Yamanishi, Kentaroh Kuwabara, Taiyo Imai, Osamu Fujino

    EUROPEAN JOURNAL OF PEDIATRICS   166 ( 10 )   1065 - 1066   2007.10

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：SPRINGER  

    DOI： 10.1007/s00431-006-0343-5

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Books

  • 症例で学ぶ栄養学

    田嶋華子（ Role： Contributor乳幼児期の栄養、成長期（学童期・思春期）の栄養）

    建帛社  2017.3 

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  • 先天代謝異常ハンドブック

    田嶋華子（ Role： Contributor異染性白質ジストロフィー）

    2013.1 

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  • ナースのミカタ

    田嶋華子（ Role： Contributor内分泌・代謝）

    医学書院  2013 

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  • ライソゾーム病－最新の病態、診断、治療の進歩ー

    田嶋華子（ Role： Contributor異染性白質ジストロフィー）

    2011 

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Misc.

  • Two Cases of Adolescent-Onset Generalized Myasthenia Gravis in Boys

    大高永字, 大高永字, 早川潤, 渡瀬絵里加, 上岡由奈, 秀野公美, 二宮理帆子, 栗原茉杏, 佐野透美, 西郡綾子, 橋本康司, 田嶋華子, 宮本雄策, 右田真

    日本小児科学会雑誌   129 ( 2 )   2025

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  • 「つぼみの会」小児糖尿病キャンプ再開後の管理栄養士の取り組み

    藤原恵子, 藤原恵子, 西村一弘, 西村一弘, 大和田彩子, 大和田彩子, 布川香織, 布川香織, 田嶋華子, 田嶋華子, 立川恵美子, 立川恵美子

    日本小児・思春期糖尿病学会年次学術集会プログラム・抄録集   30th   2025

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  • 「つぼみの会」小児糖尿病サマーキャンプにおける栄養授業の効果検討

    西村一弘, 西村一弘, 藤原恵子, 藤原恵子, 大和田彩子, 大和田彩子, 布川香織, 布川香織, 田嶋華子, 田嶋華子, 立川恵美子, 立川恵美子

    日本小児・思春期糖尿病学会年次学術集会プログラム・抄録集   30th   2025

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  • Two Pediatric Cases of Hypoglycemia due to Carnitine Deficiency Caused by Food Selectivity or Reduced Dietary Intake

    山口莉世, 山口莉世, 田嶋華子, 上春光司, 栗原茉杏, 橋本康司, 西郡綾子, 早川潤, 浅野健, 右田真

    日本医科大学医学会雑誌   21 ( 2 )   2025

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  • A case of marked QT prolongation due to hypocalcemia with dietary restriction for food allergy

    渡邉誠, 田嶋華子, 栗原茉杏, 嶋田香苗

    日本小児科学会雑誌   128 ( 2 )   377 - 377   2024.2

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  • Two cases of hypoglycemic attacks with carnitine deficiency caused by unbalanced diet and poor dietary intake

    山口莉世, 山口莉世, 山口莉世, 田嶋華子, 竹内雅彦, 太田悠佳, 上春光司, 栗原茉杏, 橋本康司, 西郡綾子, 高木篤史, 阿部正徳, 山西愼吾, 早川潤, 浅野健, 右田真

    日本小児科学会雑誌   128 ( 2 )   409 - 409   2024.2

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  • Clinical features of low serum alkaline phosphatase activity: a retrospective study

    栗原茉杏, 田嶋華子, 田嶋華子, 石井龍, 松本多絵, 上岡由奈, 秀野公美, 伊藤保彦, 右田真

    日本小児科学会雑誌   128 ( 2 )   374 - 374   2024.2

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  • 途絶えたノウハウの継承について

    布川香織, 布川香織, 田嶋華子, 田嶋華子, 立川恵美子, 立川恵美子, 佐藤詩子, 佐藤詩子

    日本小児・思春期糖尿病学会年次学術集会プログラム・抄録集   29th   2024

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  • 6 cases of monogenic diabetes detected by school-based urine glucose screening system

    田嶋華子, 田嶋華子, 堀川幸男, 堀川幸男, 右田真

    日本小児内分泌学会学術集会プログラム・抄録集   57th   2024

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  • A Case of Early Tooth Loss Requiring Differential Diagnosis of Hypophosphatasia and Vitamin D Deficiency Rickets

    根本(山本)晴子, 小口恭徳, 秋鹿ゆい, 石川友里香, 皆川莉那, 小川京, 田嶋華子, 清水武彦

    小児歯科学雑誌   62 ( 3 )   2024

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  • Suspected Wilson’s disease based on hemolytic anemia with a negative Coombs test

    板橋寿和, 山川佳丈, 小林光一, 福永遼平, 田辺雄次郎, 海津聖彦, 田嶋華子, 植田高弘

    日本小児血液・がん学会雑誌(Web)   61 ( 4 )   2024

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  • ジアゾキシド不応性先天性高インスリン血症治療戦略における臨床課題

    高澤啓, 酢谷明人, 滝島茂, 田嶋華子, 増江道哉, 鹿島田健一

    日本内分泌学会雑誌   100 ( 1 )   2024

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  • 過多月経により頻回輸血を要した多嚢胞性卵巣症候群の症例

    唐木英一, 橋本佳亮, 山川佳丈, 二宮理帆子, 松井亮介, 岡田創, 田嶋華子, 白石達典, 鈴木俊治, 伊藤保彦

    日本小児科学会雑誌   128 ( 11 )   2024

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  • 【成長曲線を書こう】成長曲線は すぐれた検査法! 思春期早発症

    田嶋 華子

    小児科診療   86 ( 11 )   1363 - 1367   2023.11

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    ＜文献概要＞▼二次性徴が通常より2～3年以上早い時期に出現し,身体的・心理的・社会的に問題を生じ得る.▼疾患頻度は女児のほうが高く,特発性が多い.一方,男児では器質性が多く原因検索が重要である.▼成長曲線を書くことで成長スパートの判断が可能となり,思春期早発症と早発乳房・早発陰毛との鑑別や,身体所見のみでは二次性徴発来の判断が難しい症例などで特に有用である.▼特発性思春期早発症でGnRHアゴニスト治療を要するのは一部の症例であり,症例ごとに適応を判断する.

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    Other Link： https://search.jamas.or.jp/default/link?pub_year=2023&ichushi_jid=J00642&link_issn=&doc_id=20231019080017&doc_link_id=10.34433%2Fpp.0000000757&url=https%3A%2F%2Fdoi.org%2F10.34433%2Fpp.0000000757&type=%E5%8C%BB%E6%9B%B8.jp_%E3%82%AA%E3%83%BC%E3%83%AB%E3%82%A2%E3%82%AF%E3%82%BB%E3%82%B9&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

  • 外来患者呼び出しシステムの導入効果に関する検討

    田嶋 華子, 高橋 美奈子, 小見渕 友子, 岡元 直子, 佐藤 その子, 山本 香絵, 鈴木 彩海, 小川 樹里, 野瀬 出, 柿沼 美紀

    小児保健研究   82 ( 講演集 )   124 - 124   2023.5

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  • 保育園、幼稚園、小学校により異なるアレルギー対応への小児科看護師が関わるアドレナリン自己注射薬の在宅自己注射指導の課題

    高橋 美奈子, 五十嵐 徹, 小見渕 友子, 岡元 直子, 佐藤 その子, 山本 香絵, 鈴木 彩海, 竹下 輝, 上春 光司, 濱本 光, 栗原 茉杏, 宮田 真貴子, 田嶋 華子, 早川 潤, 右田 真

    小児保健研究   82 ( 講演集 )   172 - 172   2023.5

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  • 多彩な症状を呈し診断に苦慮したPFAPA症候群の1歳男児例

    武森 渉, 高瀬 章弘, 安成 大輔, 岡部 公樹, 川野 聖明, 若槻 雅敏, 赤峰 裕子, 松崎 寛司, 沼田 里奈, 田場 直彦, 本村 知華子, 本荘 哲, 小田嶋 博

    日本小児科学会雑誌   127 ( 5 )   780 - 780   2023.5

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  • 脊髄脂肪腫を合併したKBG症候群の1女児例

    高木 篤史, 岡田 創, 川上 康彦, 石坂 栄太郎, 柳 久美子, 要 匡, 田嶋 華子, 伊藤 保彦

    脳と発達   55 ( Suppl. )   S405 - S405   2023.5

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  • A Case of Doose Syndrome Successfully Treated with Ethosuximide in a 3-Year-Old Boy Diagnosed after Carbamazepine Administration Induced Myoclonic Seizures

    大高永字, 宮本雄策, 橋本康司, 原田こと葉, 田嶋華子, 小川樹里, 早川潤, 川上康彦, 右田真

    日本医科大学医学会雑誌   19 ( 2 )   171 - 176   2023.4

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  • 保育園,幼稚園,小学校により異なるアレルギー対応への小児科看護師が関わるアドレナリン自己注射薬の在宅自己注射指導の課題

    高橋美奈子, 五十嵐徹, 小見渕友子, 岡元直子, 佐藤その子, 山本香絵, 鈴木彩海, 竹下輝, 上春光司, 濱本光, 栗原茉杏, 宮田真貴子, 田嶋華子, 早川潤, 右田真

    小児保健研究(Web)   82 ( Suppl )   2023

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  • A new treatment strategy for congenital hyperinsulinism using lanreotide and continuous glucose monitoring

    山野春樹, 家村綾正, 桐野玄, 秀野公美, 齋藤洋子, 齋藤洋子, 安達恵利子, 田嶋華子, 森尾友宏, 鹿島田健一, 高澤啓

    日本小児内分泌学会学術集会プログラム・抄録集   56th   2023

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  • 外来患者呼び出しシステムの導入効果に関する検討

    田嶋華子, 高橋美奈子, 小見渕友子, 岡元直子, 佐藤その子, 山本香絵, 鈴木彩海, 小川樹里, 野瀬出, 柿沼美紀

    小児保健研究(Web)   82 ( Suppl )   2023

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  • 乳歯早期脱落を主訴に受診し,精査を施行した9症例

    田嶋華子, 田嶋華子, 河上智美, 河上智美, 根本(山本)晴子, 栗原茉杏, 渡邉淳, 右田真, 伊藤保彦

    日本先天代謝異常学会雑誌   39   2023

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  • 幼児期から過食・高度肥満を有し,10歳で2型糖尿病を発症した16p11.2反復遠位欠失の一症例

    田嶋華子, 藤田武久, 右田真

    日本小児・思春期糖尿病学会年次学術集会プログラム・抄録集   28th   2023

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  • Thyroid function in pediatric fulminant type 1 diabetes mellitus

    南谷幹史, 南谷幹史, 志賀健太郎, 田嶼朝子, 鹿島田健一, 河田泰定, 福田謙, 小谷裕美子, 喜多村美幸, 三浦順之助, 高橋郁子, 田嶋華子, 横田一郎, 杉原茂孝, 菊池透

    日本小児内分泌学会学術集会プログラム・抄録集   56th   2023

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  • 低ALP血症を呈した症例の疾患,病態の後方視的検討

    栗原茉杏, 田嶋華子, 石井龍, 松本多絵, 伊藤保彦, 右田真

    日本先天代謝異常学会雑誌   39   2023

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  • 比較心理学の視点から痛みの表出機能を考える 子ども/伴侶動物の痛みの表出と養育行動の関係

    財部盛久, 百田豊, 田嶋華子, 静進, 上村佳世子

    日本発達心理学会大会プログラム(CD-ROM)   34th   2023

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  • 頭囲拡大と発達遅滞で発症し,MLC1遺伝子変異を認めたMegalencephalic leukoencephalopathy with subcortical cystsの1例

    田嶋 華子, 小川 樹里, 川上 康彦, 右田 真

    日本医科大学医学会雑誌   18 ( 4 )   453 - 453   2022.12

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  • COVID-19を発症したX連鎖無ガンマグロブリン血症(BTK欠損症)の乳児例

    杉原 諄哉, 栗原 茉杏, 竹下 輝, 田嶋 華子, 早川 潤, 右田 真, 楢崎 秀彦

    日本小児感染症学会総会・学術集会プログラム・抄録集   54回   266 - 266   2022.11

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  • The Current Problems and Signicances of Our Diabetes Camp held in Ryouzen, Fukushima

    武居正郎, 布川香織, 立川恵美子, 田嶋華子, 佐藤詩子

    日本小児科学会雑誌   126 ( 2 )   436 - 436   2022.2

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  • バセドウ病と1型糖尿病を短期間に併発した自己免疫性多内分腺症候群3型小児例

    山縣田, 築野香苗, 田嶋華子, 伊藤保彦

    日本小児科学会雑誌   126 ( 3 )   2022

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  • A case of Megalencephalic leukoencephalopathy with subcortical cysts with MLC1 gene mutation

    田嶋華子, 小川樹里, 山本俊至, 川上康彦, 右田真

    日本小児科学会雑誌   126 ( 2 )   2022

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  • INSRとPAX4遺伝子変異によるdigenicな糖尿病の母子例

    田嶋華子, 中島泰, 堀川幸男, 伊藤保彦

    糖尿病(Web)   65 ( 7 )   2022

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  • 糖尿病キャンプ専用施設の閉鎖にあたり,キャンプの今後を考える

    布川香織, 田嶋華子, 立川恵美子, 佐藤詩子, 武居正郎

    日本小児・思春期糖尿病学会年次学術集会プログラム・抄録集   27th   2022

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  • A Case of Midgut Volvulus with Intestinal Malrotation in a 4-year-old Boy

    濱本光, 竹下輝, 佐野透美, 上春光司, 橋本康司, 田嶋華子, 早川潤, 宮尾昌樹, 高橋翼, 右田真

    日本医科大学医学会雑誌   17 ( 4 )   2021

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  • The activitities of Children diabetice Patient group with the COVID-19 peril

    布川香織, 布川香織, 立川恵美子, 立川恵美子, 田嶋華子, 田嶋華子, 佐藤詩子, 佐藤詩子, 武居正郎, 武居正郎

    日本小児内分泌学会学術集会プログラム・抄録集   54th   2021

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  • siblings with different onset mode of type 1 diabetes mellitus

    田嶋華子, 山西愼吾, 伊藤保彦

    日本小児内分泌学会学術集会プログラム・抄録集   54th   2021

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  • 幼児期に糖尿病ケトアシドーシスに皮下気腫・縦郭気腫を合併し,Hamman症候群と診断した一例

    濱本光, 田嶋華子, 竹下輝, 佐野透美, 右田真

    神奈川医学会雑誌   48 ( 2 )   2021

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  • ウイルス感染とその合併症-「風邪は万病のもと」を考える 6 1型糖尿病

    田嶋華子

    小児科   62 ( 12 )   2021

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  • 学校検尿で発見され,確定診断までに時間を要した緩徐進行1型糖尿病の2症例

    田嶋華子, 高橋美奈子, 右田真

    小児保健研究(Web)   80 ( Suppl )   2021

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  • つぼみの会での小児糖尿病オンラインキャンプの試み

    布川香織, 武居正郎, 立川恵美子, 田嶋華子, 藤原恵子, 鈴木順子, 西村一弘, 小池日登美, 布川香織, 武居正郎, 立川恵美子, 田嶋華子, 藤原恵子, 鈴木順子, 西村一弘, 小池日登美

    日本小児・思春期糖尿病学会年次学術集会プログラム・抄録集   26th   2021

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  • 小児糖尿病サマーキャンプの効果と満足度に関する調査研究

    古園美和, 古園美和, 古園美和, 古園美和, 古園美和, 田嶋華子, 佐野透美, 竹下輝, 橋本康司, 早川潤, 五十嵐徹, 川上康彦, 右田真, 磯島豪, 小島あきら, 門脇弘子, 丸山博, 佐藤詩子, 入江学

    小児保健研究(Web)   79 ( Suppl )   2020

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  • 日常診療に潜むヨード過剰を契機に発症した甲状腺機能低下症-4症例の経験と考察-

    田嶋華子, 古園美和, 深澤隆治, 竹下輝, 佐野透美, 橋本康司, 早川潤, 五十嵐徹, 小林光一, 楊井瑛美, 川上康彦, 宮田真貴子, 高橋美奈子, 右田真

    小児保健研究(Web)   79 ( Suppl )   2020

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  • 胸痛を契機に診断されたSAPHO症候群の1例

    松井 亮介, 田辺 雄次郎, 鈴木 たまほ, 佐野 透美, 橋本 愛子, 田嶋 華子, 山西 慎吾, 楢崎 秀彦, 柳原 剛, 勝部 康弘, 伊藤 保彦

    日本小児科学会雑誌   123 ( 2 )   382 - 382   2019.2

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  • 若年女性の腎機能障害から診断に至ったミトコンドリア病の一例

    楊 朋洋, 三井 亜希子, 林田 真由子, 荒川 裕輔, 平間 章郎, 酒井 行直, 田嶋 華子, 清水 章, 鶴岡 秀一

    日本腎臓学会誌   60 ( 6 )   918 - 918   2018.8

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  • 若年女性の腎機能障害から診断に至ったミトコンドリア病の一例

    楊 朋洋, 三井 亜希子, 林田 真由子, 荒川 裕輔, 平間 章郎, 酒井 行直, 田嶋 華子, 清水 章, 鶴岡 秀一

    日本腎臓学会誌   60 ( 6 )   918 - 918   2018.8

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  • 小児期における血清ALP基準値設定の有用性 小児期以降発症の低ホスファターゼ症を見逃さないために

    渡邉 淳, 田嶋 華子, 川村 麻椰, 佐原 知子, 遠藤 康実

    臨床化学   47 ( Suppl.1 )   342 - 342   2018.7

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  • 乳歯早期脱落を機に受診し低ホスファターゼ症(歯限局型)と診断した1例

    田嶋 華子, 根本 晴子, 佐々木 元子, 伊藤 保彦

    日本小児科学会雑誌   120 ( 11 )   1696 - 1696   2016.11

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  • 小児期におけるALP基準値設定の有用性 小児期発症の低フォスファターゼ症を見逃さないために

    渡邉 淳, 田嶋 華子, 佐々木 元子, 青砥 泰二, 橋本 政子, 本間 博, 伊藤 保彦, 野間 桂, 中谷 中

    臨床病理   64 ( 補冊 )   4 - 14   2016.9

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  • 高ガラクトース血症を契機に診断された肝内門脈-肝静脈シャントおよび肝内血管腫の1例

    上田 美希, 勝部 康弘, 星野 レイ, 徐 東博, 田嶋 華子, 赤尾 見春, 海津 聖彦, 柳原 剛

    小児科臨床   69 ( 8 )   1397 - 1402   2016.8

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    症例は1ヵ月25日の女児。新生児マス・スクリーニング検査で高ガラクトース血症を指摘され、前医より紹介された。初診時は無症状であり、左肩部に皮膚血管腫を認めた。腹部超音波検査で肝に腫瘤を認め精査目的に腹部造影CTを施行したところ、多発性肝内血管腫および肝内門脈-肝静脈シャントを認めた。そのため高ガラクトース血症はこれらのシャントによるものと考えられた。乳糖除去を開始したところ高ガラクトース血症は改善し、血中のアンモニアおよび総胆汁酸値は一過性に高値を示したものの合併症なく経過し、生後7ヵ月現在は無治療で発育・発達とも良好である。新生児マス・スクリーニングで発見される軽度の高ガラクトース血症の原因として門脈体循環シャントは重要である。門脈体循環シャントは肝性脳症や肺高血圧などの合併症を生じ得るため、疑った場合には積極的に造影CTを含めた画像評価を行い、慎重に経過観察をする必要がある。(著者抄録)

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  • 高ガラクトース血症を契機に診断された肝血管内皮腫および門脈-肝静脈シャントの一例

    上田 美希, 赤尾 見春, 徐 東博, 星野 レイ, 田嶋 華子, 海津 聖彦, 柳原 剛, 勝部 康弘

    日本小児科学会雑誌   120 ( 2 )   483 - 483   2016.2

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  • 急性期に患側中大脳動脈の拡張を認めたMELASの1例

    高木 篤史, 上田 美希, 田嶋 華子, 小川 樹里, 伊藤 保彦

    脳と発達   47 ( Suppl. )   S343 - S343   2015.5

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  • Fetal gene therapy for lethal murine hypophosphatasia

    Hanako Sugano, Osamu Iijima, Atsushi Watanabe, Yoshitaka Fukunaga, Takashi Shimada

    JOURNAL OF GENE MEDICINE   16 ( 7-8 )   252 - 252   2014.7

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  • 痙攣・意識障害を主訴に発見されたMCAD欠損症の1例

    西郡 綾子, 田嶋 華子, 伊藤 保彦

    日本小児科学会雑誌   118 ( 7 )   1145 - 1145   2014.7

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  • hereditary hemorrhagic teleangiectasia Rendou-Osler-Weber病の母娘例

    渡邉 誠, 菅野 華子, 深澤 隆治, 小川 俊一

    日本小児肺循環研究会プログラム・抄録集   20回   25 - 25   2014.2

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  • Atypical complete DiGeorge syndrome 2例の免疫学的解析

    ブ・バン・クワン, 和田 泰三, 東馬 智子, 谷内江 昭宏, 田嶋 華子, 前田 美穂, 田中 理沙, 大石 勉

    日本小児科学会雑誌   116 ( 12 )   1956 - 1956   2012.12

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  • 知っておきたい代謝異常症の知識 3 シトリン欠損症

    田嶋華子, 高柳正樹

    小児科   53 ( 10 )   2012

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  • 低フォスファターゼ症モデルマウスの胎児期遺伝子治療

    菅野 華子, 飯島 修, 渡邉 淳, 福永 慶隆, 島田 隆

    日本先天代謝異常学会雑誌   27 ( 2 )   226 - 226   2011.10

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  • 日本における周産期型低フォスファターゼ症 高頻度変異部位1559delTと周産期時期からのfollow upの重要性

    渡邉 淳, 菅野 華子, 飯島 修, 折茂 英生, 島田 隆

    日本骨代謝学会学術集会プログラム抄録集   29回   264 - 264   2011.7

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  • 低フォスファターゼ症マウスの胎児期遺伝子治療

    菅野 華子, 飯島 修, 渡邉 淳, 島田 隆

    日本骨代謝学会学術集会プログラム抄録集   29回   184 - 184   2011.7

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  • 骨髄細胞移植による低フォスファターゼ症の遺伝子治療

    飯島 修, 菅野 華子, 渡邉 淳, 島田 隆

    日本骨代謝学会学術集会プログラム抄録集   29回   215 - 215   2011.7

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  • 周産期型低フォスファターゼ症の遺伝診療 周産期からのfollow-upの必要性

    渡辺 淳, 鈴木 由美, 菅野 華子, 峯 克也, 阿部 崇, Banyar Than Naing, 竹下 俊行, 折茂 英生, 澤井 英明, 島田 隆

    家族性腫瘍   11 ( 2 )   A70 - A70   2011.5

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  • 周産期型低フォスファターゼ症の遺伝診療 周産期からのfollow-upの必要性

    渡辺 淳, 鈴木 由美, 菅野 華子, 峯 克也, 阿部 崇, Banyar Than Naing, 竹下 俊行, 折茂 英生, 澤井 英明, 島田 隆

    日本遺伝カウンセリング学会誌   32 ( 2 )   70 - 70   2011.5

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  • 胎児期遺伝子治療 重症型低フォスファターゼ症マウス胎児への遺伝子導入

    菅野 華子, 渡邉 淳, 島田 隆

    日本遺伝カウンセリング学会誌   32 ( 2 )   71 - 71   2011.5

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Presentations

  • The Impact of Childhood Disease on Hospital Visitation Timing; Down Syndrome and Other Chronic Diseases – A survey of pediatricians in JAPAN.

    Hanako Tajima, Juri Ogawa, Izuru Nose, Yutaka Momota, Morihisa Takarabe, Miki Kakinuma

    Down syndrome research forum 2021  2021.3 

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  • 日常診療に潜むヨード過剰 ヨード過剰を契機に発症した甲状腺機能低下症―4症例の経験と考察―

    田嶋華子

    第67回日本小児保健協会学術集会  2020.11 

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  • DISEASE RELATED EXPERIENCES OF PARENTS MAY INFLUENCE THE HOSPITAL VISITATION TIMING OF CHILDREN WITH ADHD, ASD AND OTHER CHRONIC DISEASES - A SURVEY OF PEDIATRICIANS IN JAPAN

    Hanako Tajima

    International Society for Developmental Psychobiology 2020 annual meeting  2020.10 

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  • Systemic injection of AAV type 9 vector in utero facilitates global gene expression in the CNS

    Hanako Sugano, Noriko Miyake, Ayumi Endo, Koichi Miyake, Takashi Shimada

    XVIII Annual Congress of the European Society of Gene and Cell Therapy  2010.10 

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  • 学校検尿で発見され、確定診断までに時間を要した緩徐進行1型糖尿病の2症例

    田嶋 華子, 高橋 美奈子, 右田 真

    第68回日本小児保健協会学術集会  2021.6 

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  • Fetal gene therapy for lethal murine hypophosphatasia International conference

    Tajima Hanako

    American Society of gene and cell tharapy  2011 

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  • 扁桃摘出術後に発症した紫斑病性腎炎の一例

    田嶋華子

    日本小児科学会学術集会  2009 

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  • Beckwith-Wiedemann症候群(BWS)の1例

    田嶋華子

    日本小児科学会東京都地方会講和会  2009 

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  • 乳歯早期脱落を機に受診し、低ホスファターゼ症（歯限局型）と診断した１例

    田嶋華子

    日本小児科学会東京都地方会講和会  2016.3 

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  • 劇症Ⅰ型糖尿病の５歳女児例

    田嶋華子

    関東小児糖尿病フォーラム  2015 

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  • Successful gene therapy in utero for lethal murine hypophosphatasia International conference

    Tajima Hanako

    2012 

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  • 胎児期遺伝子治療－重症型低フォスファターゼ症マウス胎児への遺伝子導入ー

    田嶋華子

    遺伝医学合同学術集会  2011 

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  • ALL維持療法中に深在性真菌症を発症した3例

    田嶋華子

    日本血液学会学術集会  2008 

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  • 急性巨核芽球性白血病を発症したAlagille症候群の一例

    菅野華子

    日本小児科学会学術集会  2008 

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  • 骨形成不全症IA型の4症例

    田嶋華子

    日本小児科学会東京都地方会講和会  2006 

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  • 多発性脳梗塞と鑑別困難だった粟粒結核の1例

    田嶋華子

    日本内科学会関東地方会  2005 

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  • 腸管重複症の胎内診断の一例

    田嶋華子

    日本未熟児新生児学会学術集会  2005 

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  • 幼児期に糖尿病ケトアシドーシスに皮下気腫・縦郭気腫を合併し、Hamman症候群と診断した一例

    濱本光, 田嶋華子, 竹下輝, 佐野透美, 右田真

    小児科学会 神奈川県地方会  2021.3 

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  • 小児糖尿病サマーキャンプの効果と満足度に関する調査研究

    古園美和, 田嶋華子, 佐野透美, 竹下輝, 橋本康司, 早川潤, 五十嵐徹, 川上康彦, 右田真, 磯島豪, 小島あきら, 門脇弘子, 丸山博, 佐藤詩子, 入江学

    第67回日本小児保健協会学術集会  2020.11 

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  • INSR とPAX4 遺伝子変異によるdigenicな糖尿病症例の母子例

    田嶋華子, 中島泰, 堀川幸男, 伊藤保彦

    第59回日本糖尿病学会関東甲信越地方会  2022.1 

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  • 異なる発症様式を呈した 1型糖尿病の同胞例

    田嶋華子, 山西愼吾, 伊藤保彦

    田嶋華子、山西愼吾、伊藤保彦  2021.10 

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  • バセドウ病と１型糖尿病を短期間に併発した 自己免疫性多内分泌腺症候群3型の小児例

    山縣 田, 田嶋華子, 築野香苗, 伊藤保彦

    日本小児科学会 第674回東京都地方会  2021.7 

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  • 糖尿病キャンプ専用施設の閉鎖にあたり、キャンプの今後を考える

    布川香織, 田嶋華子, 立川恵美子, 佐藤詩子, 武居正郎

    第27回日本小児・思春期糖尿病学会学術集会  2022.7 

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  • COVID-19を発症したX連鎖無ガンマグロブリン血症(BTK欠損症)の乳児例

    杉原 諄哉, 栗原 茉杏, 竹下 輝, 田嶋 華子, 早川 潤, 右田 真, 楢崎 秀彦

    日本小児感染症学会総会・学術集会  2022.11 

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  • 日本で唯一の糖尿病児の為の固定したキャンプ場の紹介と問題点

    武居正郎, 布川香織, 立川恵美子, 田嶋華子, 佐藤詩子

    第125回日本小児科学会学術集会  2022.4 

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  • 頭囲拡大と発達遅滞で発症し、MLC1遺伝子変異を認めたMegalencephalic leukoencephalopathy with subcortical cystsの一例

    田嶋華子, 小川樹里, 川上康彦, 右田真

    第90回日本医科大学医学会総会  2022.9 

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  • 乳歯早期脱落を契機に受診し、ビタミンD欠乏性くる病と診断した2症例 －低ホスファターゼ症との鑑別の重要性－

    根本(山本)晴子, 田嶋華子, 清水武彦

    ALPS研究会  2025.7 

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  • 比較心理学の視点から痛みの表出機能を考える、子ども/伴侶動物の痛みの表出と養育行動の関係について

    柿沼美紀, 田嶋華子, 百田豊, 財部盛久

    日本発達心理学会第34回大会(シンポジウム)  2023.3 

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  • 脊髄脂肪腫を合併したKBG症候群の1女児例

    高木 篤史, 岡田 創, 川上 康彦, 石坂 栄太郎, 柳 久美子, 要 匡, 田嶋 華子, 伊藤 保彦

    日本小児神経学会  2023.5 

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  • 保育園、幼稚園、小学校により異なるアレルギー対応への小児科看護師が関わるアドレナリン自己注射薬の在宅自己注射指導の課題

    高橋 美奈子, 五十嵐 徹, 小見渕 友子, 岡元 直子, 佐藤 その子, 山本 香絵, 鈴木 彩海, 竹下 輝, 上春 光司, 濱本 光, 栗原 茉杏, 宮田 真貴子, 田嶋 華子, 早川 潤, 右田 真

    日本小児保健協会学術集会  2023.3 

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  • 外来患者呼び出しシステムの導入効果に関する検討

    田嶋 華子, 高橋 美奈子, 小見渕 友子, 岡元 直子, 佐藤 その子, 山本 香絵, 鈴木 彩海, 小川 樹里, 野瀬 出, 柿沼 美紀

    日本小児保健協会学術集会  2023.3 

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  • 幼児期から過食・高度肥満を有し、10歳で2型糖尿病を発症した16p11.2反復遠位欠失の一症例

    田嶋華子, 藤田武久, 右田真

    日本小児思春期糖尿病学会  2023.7 

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  • 乳歯早期脱落を主訴に受診し、精査を施行した9症例

    田嶋華子, 河上智美, 根本(山本)晴子, 栗原茉杏, 渡邉淳, 右田真, 伊藤保彦

    日本先天代謝異常学会  2023.10 

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  • 低ALP血症を呈した症例の疾患、病態の後方視的検討

    栗原茉杏, 田嶋華子, 石井龍, 松本多絵, 伊藤保彦, 右田真

    日本小児科学会学術集会  2024.4 

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  • 食事摂取不良によるカルニチン欠乏で低血糖発作を来した幼児２例

    山口莉世, 田嶋華子, 竹内雅彦, 太田悠佳, 上春光司, 栗原茉杏, 橋本康司, 西郡綾子, 高木篤史, 阿部正徳, 山西慎吾, 早川潤, 浅野健, 右田真

    日本小児科学会学術集会  2025.4 

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  • 小児1型糖尿病の発症様式に関する検討 小児インスリン治療研究会第5コホートより

    田嶋華子, 志賀健太郎, 高橋郁子, 横道洋司, 菊池透

    日本糖尿病学会学術集会  2025.5 

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  • 食物アレルギーに対する厳格な食事制限により著明なQT延長および低カルシウム血症を認めた1例

    渡邉 誠, 田嶋 華子, 栗原 茉杏, 嶋田 香苗

    日本小児科学会学術集会  2024.4 

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  • 学校検尿を契機に発見された単一遺伝子異常による糖尿病の6症例

    田嶋華子, 堀川幸男, 右田真

    日本小児内分泌学会学術集会  2024.10 

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  • 低ホスファターゼ症：子の診断を契機に親の診断にいたった2家系

    上岡由奈, 田嶋華子, 松本多絵, 根本(山本)晴子, 右田真

    日本小児保健協会学術集会  2025.6 

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Awards

  • 若手奨励賞

    2011.7   日本遺伝カウンセリング学会   胎児期遺伝子治療－重症型低ホスファターゼ症マウス胎児への遺伝子導入ー

    田嶋華子

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Research Projects

  • Understanding the mechanism of pain in children as a social cognitive ability

    Grant number：18K03047  2018.4 - 2023.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Kakinuma Miki

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    Grant amount：\4420000 （ Direct Cost: \3400000 、 Indirect Cost：\1020000 ）

    We have examined the mechanism of pain expression in comparative manner. Based on Craig's view on pain as social communication process(2009), we hypothesized that caretaker takes care of the child or pet according to the pain expression of them. Based on surveys to veterinarians and pediatrics indicated that dog breeds / disease differences were observed in their pain expression. Children with autistic spectrum disorder or mental retardation had specific ways of expressing their pain. Survey of parents also suggested that they base on the observation of child's pain expression. If the dog/child do not express pain much, they end up at the medical clinics with more severe conditions than others and such. These results suggest that medical stuff need to explain the characteristics of pain expression of dog/child with various dog breeds/diseases accordingly. Our hypothesis supported that pain expression is a communication tool to protect oneself and get help when expressed properly.

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