Updated on 2024/04/10

写真a

 
Koeda Michihiko
 
Affiliation
Tamanagayama Hospital, Department of Neuropsychiatry, Associate Professor
Title
Associate Professor
Profile

March 1999: Graduation: faculty of medicine, Iwate Medical University (Iwate, Japan)

(MD was obtained in May, 1999.)

April 1999- March 2001:
Resident, Department of Neurology, Iwate Medical University, (Iwate, Japan)


April 2001- March 2006:
Post-graduate Studies, Medical Research Institute (Bioinfomatics), Tokyo Medical and Dental University, (Tokyo, Japan), (PhD was awarded in March, 2006.)
April 2006-March 2015:
Assistant Professor, Department of Neuropsychiatry, Nippon Medical School, (Tokyo, Japan)
August 2011-July 2013:
Visiting Researcher, Institute of Neuroscience and Psychology, University of Glasgow, UK


April 2015-September 2020:
Senior Assistant Professor (Lecturer), Department of Neuropsychiatry, Nippon Medical School, (Tokyo, Japan)

 

Visiting Researcher:

- July 2019 - September 2019: La Timone Institute (Neuroscience), Aix-Marseille university (France)

- March 2019-May 2019, and October 2019-Nobember 2019: Biomedical Imaging, Monash University, (Australia)

- November 2019- January 2020: Department of Psychiatry and Neurochemistry, Sahlgrenska University Hospital, Gothenburg University (Sweden)

 

April 2020-September 2020:
Chief of Medicine, Department of Neuropsychiatry, Nippon Medical School Tama-Nagayama Hospital (Tokyo, Japan)


October 2020-present:

Chief of Medicine and Associate Professor, Department of Neuropsychiatry, Nippon Medical School Tama-Nagayama Hospital, (Tokyo, Japan)

Associate Professor, Department of Neuropsychiatry, Graduate School of Medicine, Nippon Medical School (Tokyo, Japan)

External link

Degree

  • MD, PhD ( 2006.3   Tokyo Medical and Dental University )

Research Interests

  • Neurological Medicine

  • psychiatry

  • functional MRI

  • functional neuroimaging

  • affective vocal processing

  • auditory language processing

  • Consultation Liaison Psychiatry

  • geriatric psychiatry

  • tau imaging

  • default mode network

  • dementia

  • auditory hallucination

  • functional connectivity

  • pharmacological fMRI

  • NIRS

  • organic psychiatry disorders

  • SNPs

Research Areas

  • Life Science / Function of nervous system  / functional neuroimaging, analysis of neuroimaging

  • Humanities & Social Sciences / Social psychology  / affective vocal processing, recognition of facial expression, cross-cultural difference of non-linguistic processing

  • Life Science / Psychiatry  / functional neuroimaging

  • Life Science / Pathophysiologic neuroscience  / tau imaging, default mode network

  • Life Science / Psychiatry  / Dementia Medicine, Delirium

  • Life Science / Psychiatry  / consultation-liaison psychiatry, geriatric psychiatry, emergency psychiatry

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Education

  • Graduate School of Medicine, Tokyo Medical and Dental University   Medical Research Institute   Department of Bioinformatics

    1999.4 - 2006.3

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  • Iwate Medical University   Faculty of Medicine

    1993.4 - 1999.3

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    Country： Japan

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Research History

  • Nippon Medical School   Department of Neuropsychitary, Graduate School of Medicine   Associate Professor

    2020.10

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  • Nippon Medical School, Tama-Nagayama Hospital   Department of Neuropsychiatry   (Head)

    2020.4

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  • University of Gothenburg   Department of Psychiatry and Neurochemistry at Institute of Neuroscience and Physiology   Visiting Researcher

    2019.11 - 2020.1

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    Country：Sweden

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  • Monash University   Biomedical Imaging   Visiting Researcher

    2019.10

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    Country：Australia

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  • Aix-Marseille University (France)   Institute of Neurosciences of la Timone   Visiting Researcher

    2019.7 - 2019.9

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    Country：France

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  • Nippon Medical School, (Tokyo, Japan)   Department of Neuropsychiatry, Graduate School of Medicine   Senior Assistant Professor (Lecturer)

    2015.4 - 2021.9

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    Country：Japan

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  • Nippon Medical School Hospital   Department of Neuropsychiatry   Senior Assistant Professor

    2015.4 - 2020.3

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  • University of Glasgow, UK   Institute of Neuroscience and Psychology, (Centre for Cognitive Neuroimaging)   Visiting Researcher

    2011.8 - 2013.7

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  • Nippon Medical School Hospital   Department of Neuropsychiatry   Assistant Professor

    2006.4 - 2015.3

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  • Tokyo Medical and Dental University   Department of Bioinformatics, Medical Research Institute   Post-graduate Student

    2001.4 - 2006.3

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  • Faculty of Medicine, Iwate Medical University   Department of Neurology   Resident

    1999.4 - 2001.3

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  • Nippon Medical School

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  • Nippon Medical School   Senior Assistant Professor

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Professional Memberships

  • JAPAN SOCIETY FOR DEMENTIA RESEARCH

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  • Japanese society of clinical neuropsychopharmacology

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  • JAPANESE SOCIETY OF NEUROLOGY

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  • THE JAPANESE SOCIETY OF INTERNAL MEDICINE

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  • JAPANESE SOCIETY OF GENERAL HOSPITAL PSYCHIATRY

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  • The Japanese society of Psychiatry and Neurology

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  • JAPANESE SOCIETY OF CLINICAL NEUROPHYSIOLOGY

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  • Japanese society of Biological Psychiatry

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  • JAPANESE PSYCHOGERIATRIC SOCIETY

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  • THE JAPANESE SOCIETY OF NEUROPSYCHOPHARMACOLOGY

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Committee Memberships

  • International Consortium on Hallucination Research   Vice President on International Consortium on Hallucination Research and Related Symptoms Kyoto 2018 Satellite Meeting  

    2017.11 - 2018.10   

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    Committee type：Academic society

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  • International Consortium on Hallucination Research   副大会長（国際幻聴研究コンソーシアム2018京都）  

    2017.11 - 2018.10   

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    Committee type：Academic society

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Papers

  • Comparison of Aversion to Visual Dental Stimuli Between Patients and Dentists: A Preliminary Study Reviewed

    Satoshi Tanaka, Hiroyuki Karibe, Yuichi Kato, Ayuko Okamoto, Michihiko Koeda, Tomoko Hama

    Patient Preference and Adherence   2024.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.2147/PPA.S447526

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  • Cerebral activation caused by dental sounds: a functional magnetic resonance imaging study Reviewed

    Hiroyuki Karibe, Michihiko Koeda, Yuichi Kato, Tomoko Hama, Satoshi Tanaka, Amane Tateno, Hidenori Suzuki, Yoshiro Okubo

    Odontology   2024.2

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    Abstract

    Dental drilling sounds can induce anxiety in some patients. This study aimed to use functional magnetic resonance imaging (fMRI) to assess the relationship between dental fear and auditory stimuli. Thirty-four right-handed individuals (21 women and 13 men; average age, 31.2 years) were selected. The level of dental fear was assessed using the dental fear survey (DFS). Based on a threshold DFS score > 52, participants were categorized into two groups: dental fear (DF) group (n = 12) and control group (n = 22). Two types of stimuli were presented in a single session: dental and neutral sounds. Cerebral activation during the presentation of these sounds was evaluated using contrast-enhanced blood oxygenation level-dependent fMRI. In the DF group, dental sounds induced significantly stronger activation in the left inferior frontal gyrus and left caudate nucleus (one-sample t test, P < 0.001). In contrast, in the control group, significantly stronger activation was observed in the bilateral Heschl’s gyri and left middle frontal gyrus (one-sample t test, P < 0.001). Additionally, a two-sample t test revealed that dental sounds induced a significantly stronger activation in the left caudate nucleus in the DF group than in the control group (P < 0.005). These findings suggest that the cerebral activation pattern in individuals with DF differs from that in controls. Increased activation of subcortical regions may be associated with sound memory during dental treatment.

    DOI： 10.1007/s10266-023-00898-7

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    Other Link： https://link.springer.com/article/10.1007/s10266-023-00898-7/fulltext.html

  • Cerebral response to emotional working memory based on vocal cues: an fNIRS study Reviewed

    Saori Ohshima, Michihiko Koeda, Wakana Kawai, Hikaru Saito, Kiyomitsu Niioka, Koki Okuno, Sho Naganawa, Tomoko Hama, Yasushi Kyutoku, Ippeita Dan

    Frontiers in Human Neuroscience   17   2023.12

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    Publishing type：Research paper (scientific journal)   Publisher：Frontiers Media SA  

    Introduction

    Humans mainly utilize visual and auditory information as a cue to infer others’ emotions. Previous neuroimaging studies have shown the neural basis of memory processing based on facial expression, but few studies have examined it based on vocal cues. Thus, we aimed to investigate brain regions associated with emotional judgment based on vocal cues using an N-back task paradigm.

    Methods

    Thirty participants performed N-back tasks requiring them to judge emotion or gender from voices that contained both emotion and gender information. During these tasks, cerebral hemodynamic response was measured using functional near-infrared spectroscopy (fNIRS).

    Results

    The results revealed that during the Emotion 2-back task there was significant activation in the frontal area, including the right precentral and inferior frontal gyri, possibly reflecting the function of an attentional network with auditory top-down processing. In addition, there was significant activation in the ventrolateral prefrontal cortex, which is known to be a major part of the working memory center.

    Discussion

    These results suggest that, compared to judging the gender of voice stimuli, when judging emotional information, attention is directed more deeply and demands for higher-order cognition, including working memory, are greater. We have revealed for the first time the specific neural basis for emotional judgments based on vocal cues compared to that for gender judgments based on vocal cues.

    DOI： 10.3389/fnhum.2023.1160392

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  • Cerebral cortical structural alteration patterns across four major psychiatric disorders in 5549 individuals Reviewed

    Junya Matsumoto, Masaki Fukunaga, Kenichiro Miura, Kiyotaka Nemoto, Naohiro Okada, Naoki Hashimoto, Kentaro Morita, Daisuke Koshiyama, Kazutaka Ohi, Tsutomu Takahashi, Michihiko Koeda, Hidenaga Yamamori, Michiko Fujimoto, Yuka Yasuda, Satsuki Ito, Ryuichi Yamazaki, Naomi Hasegawa, Hisashi Narita, Satoshi Yokoyama, Ryo Mishima, Jun Miyata, Yuko Kobayashi, Daiki Sasabayashi, Kenichiro Harada, Maeri Yamamoto, Yoji Hirano, Takashi Itahashi, Masahito Nakataki, Ryu-ichiro Hashimoto, Khin K. Tha, Shinsuke Koike, Toshio Matsubara, Go Okada, Reiji Yoshimura, Osamu Abe, Theo G. M. van Erp, Jessica A. Turner, Neda Jahanshad, Paul M. Thompson, Toshiaki Onitsuka, Yoshiyuki Watanabe, Koji Matsuo, Hidenori Yamasue, Yasumasa Okamoto, Michio Suzuki, Norio Ozaki, Kiyoto Kasai, Ryota Hashimoto

    Molecular Psychiatry   2023.8

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    Abstract

    According to the operational diagnostic criteria, psychiatric disorders such as schizophrenia (SZ), bipolar disorder (BD), major depressive disorder (MDD), and autism spectrum disorder (ASD) are classified based on symptoms. While its cluster of symptoms defines each of these psychiatric disorders, there is also an overlap in symptoms between the disorders. We hypothesized that there are also similarities and differences in cortical structural neuroimaging features among these psychiatric disorders. T1-weighted magnetic resonance imaging scans were performed for 5,549 subjects recruited from 14 sites. Effect sizes were determined using a linear regression model within each protocol, and these effect sizes were meta-analyzed. The similarity of the differences in cortical thickness and surface area of each disorder group was calculated using cosine similarity, which was calculated from the effect sizes of each cortical regions. The thinnest cortex was found in SZ, followed by BD and MDD. The cosine similarity values between disorders were 0.943 for SZ and BD, 0.959 for SZ and MDD, and 0.943 for BD and MDD, which indicated that a common pattern of cortical thickness alterations was found among SZ, BD, and MDD. Additionally, a generally smaller cortical surface area was found in SZ and MDD than in BD, and the effect was larger in SZ. The cosine similarity values between disorders were 0.945 for SZ and MDD, 0.867 for SZ and ASD, and 0.811 for MDD and ASD, which indicated a common pattern of cortical surface area alterations among SZ, MDD, and ASD. Patterns of alterations in cortical thickness and surface area were revealed in the four major psychiatric disorders. To our knowledge, this is the first report of a cross-disorder analysis conducted on four major psychiatric disorders. Cross-disorder brain imaging research can help to advance our understanding of the pathogenesis of psychiatric disorders and common symptoms.

    DOI： 10.1038/s41380-023-02224-7

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    Other Link： https://www.nature.com/articles/s41380-023-02224-7

  • Characteristics of healthy Japanese young adults with respect to recognition of facial expressions: a preliminary study Reviewed

    Tomoko Hama, Michihiko Koeda

    BMC Psychology   11 ( 1 )   1 - 10   2023.8

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    Abstract

    Background

    Emotional cognitive impairment is a core phenotype of the clinical symptoms of psychiatric disorders. The ability to measure emotional cognition is useful for assessing neurodegenerative conditions and treatment responses. However, certain factors such as culture, gender, and generation influence emotional recognition, and these differences require examination. We investigated the characteristics of healthy young Japanese adults with respect to facial expression recognition.

    Methods

    We generated 17 models of facial expressions for each of the six basic emotions (happiness, sadness, anger, fear, disgust, and surprise) at three levels of emotional intensity using the Facial Acting Coding System (FACS). Thirty healthy Japanese young adults evaluated the type of emotion and emotional intensity the models represented to them.

    Results

    Assessment accuracy for all emotions, except fear, exceeded 60% in approximately half of the videos. Most facial expressions of fear were rarely accurately recognized. Gender differences were observed with respect to both faces and participants, indicating that expressions on female faces were more recognizable than those on male faces, and female participants had more accurate perceptions of facial emotions than males.

    Conclusion

    The videos used may constitute a dataset, with the possible exception of those that represent fear. The subject’s ability to recognize the type and intensity of emotions was affected by the gender of the portrayed face and the evaluator’s gender. These gender differences must be considered when developing a scale of facial expression recognition.

    DOI： 10.1186/s40359-023-01281-5

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    Other Link： https://link.springer.com/article/10.1186/s40359-023-01281-5/fulltext.html

  • Subcortical volumetric alterations in four major psychiatric disorders: a mega-analysis study of 5604 subjects and a volumetric data-driven approach for classification Reviewed

    Naohiro Okada, Masaki Fukunaga, Kenichiro Miura, Kiyotaka Nemoto, Junya Matsumoto, Naoki Hashimoto, Masahiro Kiyota, Kentaro Morita, Daisuke Koshiyama, Kazutaka Ohi, Tsutomu Takahashi, Michihiko Koeda, Hidenaga Yamamori, Michiko Fujimoto, Yuka Yasuda, Naomi Hasegawa, Hisashi Narita, Satoshi Yokoyama, Ryo Mishima, Takahiko Kawashima, Yuko Kobayashi, Daiki Sasabayashi, Kenichiro Harada, Maeri Yamamoto, Yoji Hirano, Takashi Itahashi, Masahito Nakataki, Ryu-ichiro Hashimoto, Khin K. Tha, Shinsuke Koike, Toshio Matsubara, Go Okada, Theo G. M. van Erp, Neda Jahanshad, Reiji Yoshimura, Osamu Abe, Toshiaki Onitsuka, Yoshiyuki Watanabe, Koji Matsuo, Hidenori Yamasue, Yasumasa Okamoto, Michio Suzuki, Jessica A. Turner, Paul M. Thompson, Norio Ozaki, Kiyoto Kasai, Ryota Hashimoto

    Molecular Psychiatry   2023.8

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    Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    Abstract

    Differential diagnosis is sometimes difficult in practical psychiatric settings, in terms of using the current diagnostic system based on presenting symptoms and signs. The creation of a novel diagnostic system using objective biomarkers is expected to take place. Neuroimaging studies and others reported that subcortical brain structures are the hubs for various psycho-behavioral functions, while there are so far no neuroimaging data-driven clinical criteria overcoming limitations of the current diagnostic system, which would reflect cognitive/social functioning. Prior to the main analysis, we conducted a large-scale multisite study of subcortical volumetric and lateralization alterations in schizophrenia, bipolar disorder, major depressive disorder, and autism spectrum disorder using T1-weighted images of 5604 subjects (3078 controls and 2526 patients). We demonstrated larger lateral ventricles volume in schizophrenia, bipolar disorder, and major depressive disorder, smaller hippocampus volume in schizophrenia and bipolar disorder, and schizophrenia-specific smaller amygdala, thalamus, and accumbens volumes and larger caudate, putamen, and pallidum volumes. In addition, we observed a leftward alteration of lateralization for pallidum volume specifically in schizophrenia. Moreover, as our main objective, we clustered the 5,604 subjects based on subcortical volumes, and explored whether data-driven clustering results can explain cognitive/social functioning in the subcohorts. We showed a four-biotype classification, namely extremely (Brain Biotype [BB] 1) and moderately smaller limbic regions (BB2), larger basal ganglia (BB3), and normal volumes (BB4), being associated with cognitive/social functioning. Specifically, BB1 and BB2–3 were associated with severe and mild cognitive/social impairment, respectively, while BB4 was characterized by normal cognitive/social functioning. Our results may lead to the future creation of novel biological data-driven psychiatric diagnostic criteria, which may be expected to be useful for prediction or therapeutic selection.

    DOI： 10.1038/s41380-023-02141-9

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    Other Link： https://www.nature.com/articles/s41380-023-02141-9

  • 多施設共同研究による統合失調症と双極性障害の大脳皮質構造画像解析

    松本 純弥, 福永 雅喜, 三浦 健一郎, 岡田 直大, 根本 清貴, 藤本 美智子, 肥田 道彦, 宮田 淳, 大井 一高, 中瀧 理仁, 吉村 玲児, 岡本 泰昌, 原田 健一郎, 橋本 直樹, 鬼塚 俊明, 山本 真江里, 山末 英典, 高橋 努, 渡邊 嘉之, 笠井 清登, 橋本 亮太

    精神神経学雑誌   ( 2023特別号 )   S398 - S398   2023.6

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    Language：Japanese   Publisher：(公社)日本精神神経学会  

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  • うつ病患者における抑うつ症状と前頭葉機能的低下に関する光トポグラフィ研究

    秋山 友美, 肥田 道彦, 大久保 善朗, 木村 真人

    心身医学   63 ( 1 )   70 - 70   2023.1

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    Language：Japanese   Publisher：(一社)日本心身医学会  

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  • Transdiagnostic comparisons of intellectual abilities and work outcome in patients with mental disorders: multicentre study International journal

    Chika Sumiyoshi, Kazutaka Ohi, Haruo Fujino, Hidenaga Yamamori, Michiko Fujimoto, Yuka Yasuda, Yota Uno, Junichi Takahashi, Kentaro Morita, Asuka Katsuki, Maeri Yamamoto, Yuko Okahisa, Ayumi Sata, Eiichi Katsumoto, Michihiko Koeda, Yoji Hirano, Masahito Nakataki, Junya Matsumoto, Kenichiro Miura, Naoki Hashimoto, Manabu Makinodan, Tsutomu Takahashi, Kiyotaka Nemoto, Toshifumi Kishimoto, Michio Suzuki, Tomiki Sumiyoshi, Ryota Hashimoto

    BJPsych Open   8 ( 4 )   e98   2022.7

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Royal College of Psychiatrists  

    Background

    Cognitive impairment is common in people with mental disorders, leading to transdiagnostic classification based on cognitive characteristics. However, few studies have used this approach for intellectual abilities and functional outcomes.

    Aims

    The present study aimed to classify people with mental disorders based on intellectual abilities and functional outcomes in a data-driven manner.

    Method

    Seven hundred and forty-nine patients diagnosed with schizophrenia, bipolar disorder, major depression disorder or autism spectrum disorder and 1030 healthy control subjects were recruited from facilities in various regions of Japan. Two independent k-means cluster analyses were performed. First, intelligence variables (current estimated IQ, premorbid IQ, and IQ discrepancy) were included. Second, number of work hours per week was included instead of premorbid IQ.

    Results

    Four clusters were identified in the two analyses. These clusters were specifically characterised in terms of IQ discrepancy in the first cluster analysis, whereas the work variable was the most salient feature in the second cluster analysis. Distributions of clinical diagnoses in the two cluster analyses showed that all diagnoses were unevenly represented across the clusters.

    Conclusions

    Intellectual abilities and work outcomes are effective classifiers in transdiagnostic approaches. The results of our study also suggest the importance of diagnosis-specific strategies to support functional recovery in people with mental disorders.

    DOI： 10.1192/bjo.2022.50

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  • うつ状態を併発した自閉症スペクトラム障害の言語処理・神経基盤の評価

    肥田 道彦, 熊谷 明宏, 大島 沙織, 新岡 陽光, 中澤 健太, 徳田 竜也, 土井 照代, 澤谷 篤, 下田 健吾, 檀 一平太, 木村 真人

    精神神経学雑誌   124 ( 4付録 )   S - 638   2022.4

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    Language：Japanese   Publisher：(公社)日本精神神経学会  

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  • Trends in big data analyses by multicenter collaborative translational research in psychiatry Reviewed

    Toshiaki Onitsuka, Yoji Hirano, Kiyotaka Nemoto, Naoki Hashimoto, Itaru Kushima, Daisuke Koshiyama, Michihiko Koeda, Tsutomu Takahashi, Yoshihiro Noda, Junya Matsumoto, Kenichiro Miura, Takanobu Nakazawa, Takatoshi Hikida, Kiyoto Kasai, Norio Ozaki, Ryota Hashimoto

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   76 ( 1 )   1 - 14   2022.1

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：WILEY  

    The underlying pathologies of psychiatric disorders, which cause substantial personal and social losses, remain unknown, and their elucidation is an urgent issue. To clarify the core pathological mechanisms underlying psychiatric disorders, in addition to laboratory-based research that incorporates the latest findings, it is necessary to conduct large-sample-size research and verify reproducibility. For this purpose, it is critical to conduct multicenter collaborative research across various fields, such as psychiatry, neuroscience, molecular biology, genomics, neuroimaging, cognitive science, neurophysiology, psychology, and pharmacology. Moreover, collaborative research plays an important role in the development of young researchers. In this respect, the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) consortium and Cognitive Genetics Collaborative Research Organization (COCORO) have played important roles. In this review, we first overview the importance of multicenter collaborative research and our target psychiatric disorders. Then, we introduce research findings on the pathophysiology of psychiatric disorders from neurocognitive, neurophysiological, neuroimaging, genetic, and basic neuroscience perspectives, focusing mainly on the findings obtained by COCORO. It is our hope that multicenter collaborative research will contribute to the elucidation of the pathological basis of psychiatric disorders.

    DOI： 10.1111/pcn.13311

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  • Modafinil Decreased Thalamic Activation in Auditory Emotional Processing: A Randomized Controlled Functional Magnetic Resonance Imaging Study. Reviewed

    Tomoko Hama, Michihiko Koeda, Yumiko Ikeda, Amane Tateno, Tokuhiro Kawara, Hidenori Suzuki, Yoshiro Okubo

    Journal of Nippon Medical School = Nippon Ika Daigaku zasshi   88 ( 5 )   485 - 495   2021.11

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Medical Association of Nippon Medical School  

    BACKGROUND: Modafinil improves wakefulness and attention, is approved in Japan for treatment of narcolepsy, and was reported to be effective for attention-deficit/hyperactivity disorder. However, it was reported to induce emotional instability, including mania, depression, and suicidal ideation. Such side effects may be related to changes in cognitive behavior caused by the effects of modafinil on emotional recognition. However, the effects of modafinil on the neural basis of emotional processing have not been fully verified. We used functional magnetic resonance imaging to investigate the effects of modafinil on the neural basis of auditory emotional processing. METHODS: This study adopted a placebo-controlled within-subject crossover design. Data from 14 participants were analyzed. The effects of modafinil on cerebral activation and task performance during an emotional judgement task were analyzed. RESULTS: Task accuracy decreased significantly and response time of emotional judgement was significantly delayed by modafinil, as compared with placebo. Right thalamic activation in auditory emotional processing was significantly less in the modafinil condition than in the placebo condition. In addition, reduction of right thalamic activation by modafinil was positively correlated with accuracy of emotional judgement. CONCLUSIONS: Our findings suggest that modafinil acts on the right thalamus and changes behavior and brain function associated with auditory emotional processing. These results indicate that modafinil might change emotional recognition by reducing emotional activation related to social communication.

    DOI： 10.1272/jnms.JNMS.2021_88-607

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  • アスペルガー症候群の傾向を有するうつ状態の言語処理・神経基盤の評価

    肥田 道彦, 熊谷 明宏, 大島 沙織, 新岡 陽光, 徳田 竜也, 土居 照代, 澤谷 篤, 下田 健吾, 木村 真人

    総合病院精神医学   33 ( Suppl. )   S - 139   2021.11

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    Language：Japanese   Publisher：(一社)日本総合病院精神医学会  

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  • Effects of anodal transcranial direct current stimulation on implicit motor learning and language‐related brain function: An fMRI study Reviewed

    Soichiro Nakashima, Michihiko Koeda, Yumiko Ikeda, Tomoko Hama, Takuya Funayama, Tomomi Akiyama, Ryosuke Arakawa, Amane Tateno, Hidenori Suzuki, Yoshiro Okubo

    Psychiatry and Clinical Neurosciences   75 ( 6 )   200 - 207   2021.6

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    Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    DOI： 10.1111/pcn.13208

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    Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1111/pcn.13208

  • Bupropion increases cerebral activation in auditory affective processing: A randomized controlled fMRI study Reviewed

    Tomoko Hama, Michihiko Koeda, Yumiko Ikeda, Amane Tateno, Tokuhiro Kawara, Hidenori Suzuki, Yoshiro Okubo

    Neuroscience Letters   749   135716 - 135716   2021.4

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    Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.neulet.2021.135716

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  • Differences in the perception of dental sounds: a preliminary study Reviewed

    Hiroyuki Karibe, Michihiko Koeda, Kyoko Aoyagi-Naka, Yuichi Kato, Amane Tateno, Hidenori Suzuki, Yoshiro Okubo

    Patient Preference and Adherence   Volume 13   1051 - 1056   2019.7

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Informa {UK} Limited  

    DOI： 10.2147/ppa.s204465

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  • Hypofunction of left dorsolateral prefrontal cortex in depression during verbal fluency task: A multi-channel near-infrared spectroscopy study Reviewed

    Tomomi Akiyama, Michihiko Koeda, Yoshiro Okubo, Mahito Kimura

    Journal of Affective Disorders   231   83 - 90   2018.4

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier B.V.  

    Background: Previous functional neuroimaging studies of depression have demonstrated frontotemporal dysfunction, including the dorsolateral prefrontal cortex, while patients perform working memory and language comprehension tasks. Recent near-infrared spectroscopy (NIRS) studies have shown frontotemporal hypofunction in depression by verbal fluency task, but the regions of impairment affecting respective depressive symptoms still remain unclear. We investigated frontotemporal function during word production task in depression with multi-channel NIRS. Further, we aimed to clarify whether any depressive symptoms affect frontotemporal dysfunction. Methods: One hundred seventy-seven major depressive patients and 50 healthy control volunteers participated in this study. Their cerebral activations were compared during verbal fluency task. Results: Although performance was not significantly different, hypoactivation in the bilateral frontotemporal regions was significantly observed in depressed patients, compared with controls. Left lateral frontotemporal activation was significantly reduced in the group with mandatory symptom, which is depressed mood, or loss of interest or pleasure, compared with the group that still has residual depressive symptoms in spite MDD having been remitted. Limitation: the MDD group had significantly higher age and education level than the controls. Conclusions Our findings indicate hypofunction of the bilateral frontotemporal regions in depression during verbal fluency task. Further, hypofunction of these regions in the left hemisphere by this task could reflect whether the subjects recovered from depressed mood, or loss of interest or pleasure.

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  • 救急患者精神科継続支援開始後の院内体制整備の取り組みに関する報告

    大高 靖史, 成重 竜一郎, 肥田 道彦, 野上 毅, 坂寄 健, 朝山 健太郎, 高野 亜希子, 高橋 馨, 金 禹瑣, 増岡 孝浩, 西川 律子, 飯田 謙司, 大久保 善朗

    総合病院精神医学   29 ( Suppl. )   S - 137   2017.11

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  • EFFECT OF CNTNAP2 POLYMORPHISMS ON CEREBRAL RESPONSE TO HUMAN VOICE PERCEPTION AND HANDEDNESS: AN FMRI STUDY Reviewed

    Michihiko Koeda, Atsushi Watanabe, Kumiko Tsuda, Miwako Matsumoto, Yumiko Ikeda, Woochan Kim, Amane Tateno, Banyar Than Naing, Hiroyuki Karibe, Takashi Shimada, Hidenori Suzuki, Masato Matsuura, Yoshiro Okubo

    JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY   88 ( 8 )   E25 - E26   2017.8

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  • MAZINDOL EFFECT ON CEREBRAL RESPONSE TO NONVERBAL AFFECTIVE VOCALISATION IN HEALTHY INDIVIDUALS: AN FMRI STUDY Reviewed

    Michihiko Koeda, Yumiko Ikeda, Amane Tateno, Hidenori Suzuki, Yoshiro Okubo

    JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY   88 ( 8 )   E35 - E36   2017.8

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  • Effect of apolipoprotein E phenotype on the association of plasma amyloid β and amyloid positron emission tomography imaging in Japan Reviewed

    Amane Tateno, Takeshi Sakayori, Woo Chan Kim, Michihiko Koeda, Shinichiro Kumita, Hidenori Suzuki, Yoshiro Okubo

    Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring   9   51 - 56   2017

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    Introduction The plasma concentration of beta-amyloid (Aβ) has been considered another biomarker of Alzheimer's disease and was reportedly associated with cortical Aβ accumulation. Methods We analyzed 28 subjects with apolipoprotein E4 (ApoE4
    E4 group) and 89 subjects without ApoE4 (non-E4 group) to determine the association between cortical Aβ accumulation by standard uptake value ratio with [18F]florbetapir positron emission tomography and plasma Aβ1–40 and Aβ1–42. Results Aβ1–42/Aβ1–40 correlated significantly with mean regional [18F]florbetapir standard uptake value ratio in the non-E4 group (R2 = 0.06, P =.02) but not in the E4 group, and receiver operating characteristic curve analysis for Aβ1–42/Aβ1–40 in the non-E4 group showed sensitivity (92.9%) and specificity (45.9%) with a cutoff value of 0.150 for Aβ positivity. Discussion We verified that the correlation between Aβ1–42/Aβ1–40 and Aβ accumulation differed according to ApoE phenotype. The high sensitivity of plasma Aβ1–42/Aβ1–40 for Aβ positivity in non-E4 subjects indicated a possible role of plasma Aβ1–42/Aβ1–40 as a screening biomarker before amyloid positron emission tomography in clinical settings.

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  • 救命救急センター退院後の自殺未遂者の回復プロセスに関する研究 定性的方法を用いた概念化、理論化の試み

    大高 靖史, 成重 竜一郎, 肥田 道彦, 大久保 善朗

    日本社会精神医学会雑誌   25 ( 3 )   263 - 264   2016.8

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  • Effect of placebo and lorazepam on functional connectivity in fearful vocal processing: an fMRI study Reviewed

    Michihiko Koeda, Takeshi Hase, Tomoko Hama, Yumiko Ikeda, Noriaki Yahata, Amane Tateno, Hidehiko Takahashi, Masato Matsuura, Hidenori Suzuki, Yoshiro Okubo

    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY   19   54 - 54   2016.6

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  • 救命救急センター退院後の自殺未遂者の回復プロセスに関する研究 定性的方法を用いた概念化、理論化の試み

    大高 靖史, 成重 竜一郎, 肥田 道彦, 大久保 善朗

    日本社会精神医学会雑誌   25 ( 2 )   174 - 174   2016.5

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  • Interaction effect between handedness and CNTNAP2 polymorphism (rs7794745 genotype) on voice-specific frontotemporal activity in healthy individuals: an fMRI study Reviewed

    Michihiko Koeda, Atsushi Watanabe, Kumiko Tsuda, Miwako Matsumoto, Yumiko Ikeda, Woochan Kim, Amane Tateno, Banyar Than Naing, Hiroyuki Karibe, Takashi Shimada, Hidenori Suzuki, Masato Matsuura, Yoshiro Okubo

    FRONTIERS IN BEHAVIORAL NEUROSCIENCE   9   87   2015.4

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    Recent neuroimaging studies have demonstrated that Contactin-associated protein-like2 (CNTNAP2) polymorphisms affect left-hemispheric function of language processing in healthy individuals, but no study has investigated the influence of these polymorphisms on right-hemispheric function involved in human voice perception. Further, although recent reports suggest that determination of handedness is influenced by genetic effect, the interaction effect between handedness and CNTNAP2 polymorphisms for brain activity in human voice perception and language processing has not been revealed. We aimed to investigate the interaction effect of handedness and CNTNAP2 polymorphisms in respect to brain function for human voice perception and language processing in healthy individuals. Brain function of 108 healthy volunteers (74 right-handed and 34 non-right-handed) was examined while they were passively listening to reverse sentences (rSEN), identifiable non-vocal sounds (SND), and sentences (SEN). Full factorial design analysis was calculated by using three factors: (1) rs7794745 (A/A or A/T), (2) rs2710102 [G/G or A carrier (A/G and A/A)], and (3) voice-specific response (rSEN or SND). The main effect of rs7794745 (A/A or A/T) was significantly revealed at the right middle frontal gyrus (MFG) and bilateral superior temporal gyrus (STG). This result suggests that rs7794745 genotype affects voice-specific brain function. Furthermore, interaction effect was significantly observed among MFG-STG activations by human voice perception, rs7794745 (A/A or A/T), and handedness. These results suggest that CNTNAP2 polymorphisms could be one of the important factors in the neural development related to vocal communication and language processing in both right-handed and non-right-handed healthy individuals.

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  • Cross-cultural differences in the processing of non-verbal affective vocalizations by Japanese and Canadian listeners Reviewed

    Michihiko Koeda, Pascal Belin, Tomoko Hama, Tadashi Masuda, Masato Matsuura, Yoshiro Okubo

    Frontiers in Psychology   4   105   2013

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  • Cerebral responses to vocal attractiveness and auditory hallucinations in schizophrenia: a functional MRI study. Reviewed

    Koeda M, Takahashi H, Matsuura M, Asai K, Okubo Y

    Frontiers in human neuroscience   7 ( 221 )   221 - 13   2013

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  • Caffeine's Effects on Attentional Networks in Healthy Subjects: A Pharmacological Functional Magnetic Resonance Imaging Study Reviewed

    Yumiko Ikeda, Michihiko Koeda, Woochan Kim, Amane Tateno, Yoshiro Okubo, Hidenori Suzuki

    JOURNAL OF NIPPON MEDICAL SCHOOL   79 ( 5 )   318 - 319   2012.10

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  • Cerebral activation associated with speech sound discrimination during the diotic listening task: An fMRI study Reviewed

    Yumiko Ikeda, Noriaki Yahata, Hidehiko Takahashi, Michihiko Koeda, Kunihiko Asai, Yoshiro Okubo, Hidenori Suzuki

    NEUROSCIENCE RESEARCH   67 ( 1 )   65 - 71   2010.5

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    Comprehending conversation in a crowd requires appropriate orienting and sustainment of auditory attention to and discrimination of the target speaker. While a multitude of cognitive functions such as voice perception and language processing work in concert to subserve this ability, it is still unclear which cognitive components critically determine successful discrimination of speech sounds under constantly changing auditory conditions. To investigate this, we present a functional magnetic resonance imaging (fMRI) study of changes in cerebral activities associated with varying challenge levels of speech discrimination. Subjects participated in a diotic listening paradigm that presented them with two news stories read simultaneously but independently by a target speaker and a distracting speaker of incongruent or congruent sex. We found that the voice of distracter of congruent rather than incongruent sex made the listening more challenging, resulting in enhanced activities mainly in the left temporal and frontal gyri. Further, the activities at the left inferior, left anterior superior and right superior loci in the temporal gyrus were shown to be significantly correlated with accuracy of the discrimination performance. The present results suggest that the subregions of bilateral temporal gyri play a key role in the successful discrimination of speech under constantly changing auditory conditions as encountered in daily life. (C) 2010 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.

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  • Functional Deficits in the Extrastriate Body Area During Observation of Sports-Related Actions in Schizophrenia Reviewed

    Hidehiko Takahashi, Motoichiro Kato, Takeshi Sassa, Tomohisa Shibuya, Michihiko Koeda, Noriaki Yahata, Masato Matsuura, Kunihiko Asai, Tetsuya Suhara, Yoshiro Okubo

    SCHIZOPHRENIA BULLETIN   36 ( 3 )   642 - 647   2010.5

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    Exercise and sports are increasingly being implemented in the management of schizophrenia. The process of action perception is as important as that of motor execution for learning and acquiring new skills. Recent studies have suggested that body-selective extrastriate body area (EBA) in the posterior temporal-occipital cortex is involved not only in static visual perception of body parts but also in the planning, imagination, and execution of actions. However, functional abnormality of the EBA in schizophrenia has yet to be investigated. Using functional magnetic resonance imaging (fMRI) with a task designed to activate the EBA by sports-related actions, we aimed to elucidate functional abnormality of the EBA during observation of sports-related actions in patients with schizophrenia. Twelve schizophrenia patients and 12 age-sex-matched control participants participated in the study. Using sports-related motions as visual stimuli, we examined brain activations during observation of context-congruent actions relative to context-incongruent actions by fMRI. Compared with controls, the patients with schizophrenia demonstrated diminished activation in the EBA during observation of sports-related context-congruent actions. Furthermore, the EBA activation in patients was negatively correlated with the severity of negative and general psychopathology symptoms measured by the Positive and Negative Syndrome Scale. Dysfunction of the EBA might reflect a difficulty in representing dynamic aspects of human actions and possibly lead to impairments of simulation, learning, and execution of actions in schizophrenia.

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  • Relationship of psychological characteristics and self-efficacy in gastrointestinal cancer survivors Reviewed

    Yuuta Kohno, Michio Maruyama, Yutaka Matsuoka, Toshiko Matsushita, Michihiko Koeda, Eisuke Matsushima

    PSYCHO-ONCOLOGY   19 ( 1 )   71 - 76   2010.1

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    To characterize gastrointestinal cancer survivors' ability to psychologically adjust, we examined the relationship between psychological characteristics (quality of life (QOL), anxiety, depression, and post-traumatic stress symptoms) and self-efficacy (perceived ability to initiate coping strategies). Forty-seven subjects (32 males and 15 females) were recruited from outpatient clinics or general surgical wards after readmission for therapy unrelated to cancer. All had undergone treatment for gastrointestinal cancer. Japanese version of the Functional Assessment of Cancer Therapy-General (FACT-G), Japanese version of Hospital Anxiety and Depression Scale (HADS), Japanese version of Impact of Event Scale-Revised (IES-R), and The Self-Efficacy Scale for Advanced Cancer (SEAC) were administered. Correlation analyses revealed a statistically significant positive correlation between three subscales of SEAC and QOL (total of FACT-G value) and a significant negative correlation between anxiety, depression (the total of HADS value), post-traumatic stress symptoms (the total of IES-R value), and SEAC. In multiple regression analysis, the influence from Affect Regulation Efficacy (subscale of SEAC) was the largest in anxiety and post-traumatic stress symptoms while the influence from Activities of Daily Living Efficacy (subscale of SEAC) was the largest in QOL and depression. Our findings revealed that a strong relationship between self-efficacy and psychological adjustment, and that there should be several psychological intervention forms performed at various treatment stages to enhance self-efficacy in this population of gastrointestinal cancer survivors. These results also imply the effectiveness of interventions on self-efficacy for gastrointestinal cancer survivors and the influence of psychological factors such as QOL, anxiety, depression, and post-traumatic stress symptoms. Copyright (C) 2009 John Wiley & Sons, Ltd.

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  • Working memory processing for human voice perception in a patient with mild cognitive impairment: An fMRI study Reviewed

    Michihiko Koeda, Amane Tateno, Kosuke Ishizaka, Tomoyuki Saijo, Yoshiro Okubo

    Journal of Nippon Medical School   77 ( 4 )   188 - 189   2010

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  • Development of clinical ontology for mood disorder with combination of psychomedical information Reviewed

    Mojgan Haghighi, Michihiko Koeda, Takako Takai, Hiroshi Tanaka

    Journal of Medical and Dental Sciences   56 ( 1 )   1 - 15   2009

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    We have developed a new educational/clinical ontology named the "Haghighi-Koeda Mood Disorder Ontology", which involves both medical and psychological approaches for mood disorders in order to promote the exchange of information between psychiatrists and psychologists. Data was gathered from more than 5000 articles published in journals and websites specialized in life science. We evaluated and selected articles which were related to 4 main categories of mood disorders. Using Protéǵ 3.4 beta, information related to mood disorders was classified by class/subclass tree in an ontological structure. Then we developed a web-based interface system on the internet enabling the implementation of the ontology. In addition, we have designed an online scale for automated diagnosis of mood disorder. For evaluating experiments, we compare this ontology with "Decisionbase™" of which content deals with mood disorders. Evaluation was in accordance with our selected criteria via the AHP (Analysis of Hierarchical Processing) method. The results demonstrated the noteworthy superiority of our ontology. We believe that combining knowledge of medical science with that in psychological fields is a key to improving the quality of diagnosis and promoting appropriate treaTMent in all psychiatric disorders.

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  • Increased Binding of Peripheral Benzodiazepine Receptor in Alzheimer's Disease Measured by Positron Emission Tomography with [C-11]DAA1106 Reviewed

    Furnihiko Yasuno, Miho Ota, Jun Kosaka, Hiroshi Ito, Makoto Higuchi, Talant K. Doronbekov, Shoko Nozaki, Yota Fujimura, Michihiko Koeda, Takashi Asada, Tetsuya Suhara

    BIOLOGICAL PSYCHIATRY   64 ( 10 )   835 - 841   2008.11

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    Background: Peripheral benzodiazepine receptor (PBR) in the brain of Alzheimer's disease (AD) patients has been discussed in relation to the role of gliosis in AD. The PBR was shown to have the ability to reflect activated glial cells, including microglia. The role of activated microglia in AD is all important topic in the pathophysiology of AD. The aim of this study was to quantify PBR in AD brain with a new high-sensitive PBR ligand, [C-11]DAA1106.
    Methods: Positron emission tomography (PET) scans with [C-11]DAA1106, a potent and selective ligand for PBR, were performed on 10 patients with AD and 10 age-matched control subjects. All patients had mild to moderate dementia. Duration of illness was 1-3 years at the time of the scans. The PBR binding in the regions of interest was quantified by binding potential (BP) obtained from compartmental model analysis with plasma input function.
    Results: Mean BP was increased in the brain of AD patients compared with control subjects in all measured regions. Statistical significance reached across many of the regions examined, including dorsal and medial prefrontal cortex, lateral temporal cortex, parietal cortex, occipital cortex, anterior cingulate cortex, striatum, and cerebellum.
    Conclusions: The broad increase of PBR binding measured with [C-11]DAA1106 in the brain of AD patients suggests a widespread existence of cellular reactions with PBR in relatively early-stage AD.

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  • Neural correlates of human virtue judgment Reviewed

    Hidehiko Takahashi, Motoichiro Kato, Masato Matsuura, Michihiko Koeda, Noriaki Yahata, Tetsuya Suhara, Yoshiro Okubo

    CEREBRAL CORTEX   18 ( 8 )   1886 - 1891   2008.8

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    Neuroimaging studies have demonstrated that the brain regions implicated in moral cognition. However, those studies have focused exclusively on violation of social norms and negative moral emotions, and very little effort has been expended on the investigation of positive reactions to moral excellence. It remains unclear whether the brain regions implicated in moral cognition have specific roles in processing moral violation or, more generally, process human morality per se. Using functional magnetic resonance imaging, brain activations during evaluation of moral beauty and depravity were investigated. Praiseworthiness for moral beauty was associated with activation in the orbitofrontal cortex, whereas blameworthiness for moral depravity was related to the posterior superior temporal sulcus. Humans might have developed different neurocognitive systems for evaluating blameworthiness and praiseworthiness. The central process of moral beauty evaluation might be related to that of aesthetic evaluation. Our finding might contribute to a better understanding of human morality.

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  • Brain activations during judgments of positive self-conscious emotion and positive basic emotion: Pride and joy Reviewed

    Hidehiko Takahashi, Masato Matsuura, Michihiko Koeda, Noriaki Yahata, Tetsuya Suhara, Motoichiro Kato, Yoshiro Okubo

    CEREBRAL CORTEX   18 ( 4 )   898 - 903   2008.4

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    We aimed to investigate the neural correlates associated with judgments of a positive self-conscious emotion, pride, and elucidate the difference between pride and a basic positive emotion, joy, at the neural basis level using functional magnetic resonance imaging. Study of the neural basis associated with pride might contribute to a better understanding of the pride-related behaviors observed in neuropsychiatric disorders. Sixteen healthy volunteers were studied. The participants read sentences expressing joy or pride contents during the scans. Pride conditions activated the right posterior superior temporal sulcus and left temporal pole, the regions implicated in the neural substrate of social cognition or theory of mind. However, against our prediction, we did not find brain activation in the medial prefrontal cortex, a region responsible for inferring others' intention or self-reflection. Joy condition produced activations in the ventral striatum and insula/operculum, the key nodes of processing of hedonic or appetitive stimuli. Our results support the idea that pride is a self-conscious emotion, requiring the ability to detect the intention of others. At the same time, judgment of pride might require less self-reflection compared with those of negative self-conscious emotions such as guilt or embarrassment.

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  • Enhanced activation in the extrastriate body area by goal-directed actions Reviewed

    Hidehiko Takahashi, Tomohisa Shibuya, Motoichiro Kato, Takeshi Sassa, Michihiko Koeda, Noriaki Yahata, Tetsuya Suhara, Yoshiro Okubo

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   62 ( 2 )   214 - 219   2008.4

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    Aim: Neuroimaging studies on biological motion have established the view that the posterior superior temporal sulcus (pSTS) is involved in detecting intention of others. Those studies have consistently reported other regions such as body-selective extrastriate body area (EBA) and motion-sensitive middle temporal, in close proximity to pSTS. Whether EBA responds only to static body parts or has a more extended role as part of a system for inferring intention of others has remained an elusive issue. The aim of the present study was to investigate the role of EBA in processing goal-directed actions.
    Methods: Twelve healthy volunteers participated in the present study. Using sports-related motions as visual stimuli, brain activations were examined during observation of goal-directed actions and non-goal-directed actions on functional magnetic resonance imaging.
    Results: Compared to non-goal-directed actions, goal-directed actions produced greater activations in EBA along with the mirror neuron system.
    Conclusions: EBA might contribute to understanding others' actions by representing the dynamic aspects of human motions.

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  • Care policy for patients with dementia: Family's decision and its impact Reviewed

    Michihiko Koeda, Takeo Shibata, Kunihiko Asai, Yoshiro Okubo, Hiroshi Tanaka

    BMEI 2008: PROCEEDINGS OF THE INTERNATIONAL CONFERENCE ON BIOMEDICAL ENGINEERING AND INFORMATICS, VOL 2   843 - +   2008

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    We developed a method using the Analytic Hierarchy Process (AHP) to evaluate the psychological factors of family caregivers of patients with dementia. Further, the family caregivers were questioned on their policy pertaining to the living place of the patients: at their home, nursing home, or hospital. We made inquiries of sixty-two families, resulting in twenty-eight desiring care at home, twenty desiring a nursing home, and fourteen desiring care at a hospital. The more the quality of life was valued, the more the family preferred care at home (r = 0.42). In contrast, the higher the concern regarding the burden of care was, the more the family preferred hospitalization (r = 0.49). This approach was useful in formulating decisions regarding a care policy for older people. Assessment of the psychological factors of family caregivers may provide clues for solving problems in decisions regarding care policy.

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  • Neural responses to human voice and hemisphere dominance for lexical-semantic processing - An fMRI study Reviewed

    M. Koeda, H. Takahashi, N. Yahata, M. Matsuura, K. Asai, Y. Okubo, H. Tanaka

    METHODS OF INFORMATION IN MEDICINE   46 ( 2 )   247 - 250   2007

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    Objectives: In our previous functional magnetic resonance imaging (fMRI) study, we determined that there was distinct left hemispheric dominance for lexical-semantic processing without the influence of human voice perception in right-handed healthy subjects. However, the degree of right-handedness in the right-handed subjects ranged from 52 to 100 according to the Edinburgh Handedness Inventory (EHI) score. In the present study, we aimed to clarify the correlation between the degree of right-handedness and language dominance in the fronto-temporo-parietal cortices by examining cerebral activation for lexical-semantic processing.
    Methods: Twenty-seven normal right-handed healthy subjects were scanned by fMRI while listening to sentences (SEN), reverse sentences (rSEN), and identifiable non-vocal sounds (SND). Fronto-temporo-parietal activation was observed in the left hemisphere under the SEN - rSEN contrast, which included lexical-semantic processing without the influence of human voice perception. Laterality index was calculated as LI = (L-R)/(L + R) x 100, L: left, R: right.
    Results: Laterality Index in the fronto-temporo-parietal cortices did not correlate with the degree of right-handedness in EHI score.
    Conclusions: The present study indicated that the degree of right-handedness from 52 to 100 in EHI score had no effect on the degree of left hemispheric dominance for lexical-semantic processing in right-handed healthy subjects.

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  • Men and women show distinct brain activations during imagery of sexual and emotional infidelity Reviewed

    Hidehiko Takahashi, Masato Matsuura, Noriaki Yahata, Michihiko Koeda, Tetsuya Suhara, Yoshiro Okubo

    NEUROIMAGE   32 ( 3 )   1299 - 1307   2006.9

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    Jealousy-related behaviors such as intimate partner violence and morbid jealousy are more common in males. Principal questionnaire studies suggest that men and women have different modules to process cues of sexual and emotional infidelity. We aimed to elucidate the neural response to sentences depicting sexual and emotional infidelity in men and women using functional magnetic resonance imaging. Although there was no sex difference in the self-rating score of jealousy for sexual and emotional infidelity, men and women showed different brain activation patterns in response to the two types of infidelity. During jealous conditions, men demonstrated greater activation than women in the brain regions involved in sexual/aggressive behaviors such as the amygdala and hypothalamus. In contrast, women demonstrated greater activation in the posterior superior temporal sulcus. Our fMRI results are in favor of the notion that men and women have different neuropsychological modules to process sexual and emotional infidelity. Our findings might contribute to a better understanding of the neural basis of the jealousy-related behaviors predominantly observed in males. (c) 2006 Elsevier Inc. All rights reserved.

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  • A functional MRI study: Cerebral laterality for lexical-semantic processing and human voice perception Reviewed

    M. Koeda, H. Takahashi, N. Yahata, K. Asai, Y. Okubo, H. Tanaka

    AMERICAN JOURNAL OF NEURORADIOLOGY   27 ( 7 )   1472 - 1479   2006.8

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：AMER SOC NEURORADIOLOGY  

    BACKGROUND AND PURPOSE: Language dominance research using functional neuromaging has made important contributions to clinical applications. Nevertheless, although recent neuroimaging studies demonstrated right-lateralized activation by human voice perception, the influence of voice perception in terms of language dominance has not been adequately studied. We aimed to accurately clarify language dominance for lexical-semantic processing in the temporal cortices by focusing on human voice perception.
    METHODS: Thirty normal right-handed subjects were scanned by functional MR imaging while listening to sentences (SEN), reverse sentences (rSEN), and identifiable nonvocal sounds (SND). We investigated cerebral activation and the distribution of individual Laterality Index under 3 contrasts: rSEN-SND. SEN-SND, and SEN-rSEN.
    RESULTS: The rSEN-SND contrast, including human voice perception, revealed right-lateralized activation in the anterior temporal cortices. Both SEN-SND and SEN-rSEN contrasts, including lexical-semantic processing, showed left-lateralized activation in the inferior and middle frontal gyrus and middle temporal gyrus. The SEN-rSEN contrast, without the influence of human voice perception, showed no temporal activation in the right hemisphere. Symmetrical or right-lateralized activation was observed in 22 of 27 subjects (81.4%) under the rSEN-SND contrast in the temporal cortices. Although 9 of 27 subjects (33.3%) showed symmetrical or right-lateralized activation under the SEN-SND contrast in the temporal cortices, all subjects showed left-lateralized activation under the SEN-rSEN contrast.
    CONCLUSION: Our results demonstrated that right-lateralized activation by human voice perception could mask left-lateralized activation by lexical-semantic processing. This finding suggests that the influence of human voice perception should be adequately taken into account when language dominance is determined.

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  • Language processing and human voice perception in schizophrenia: A functional magnetic resonance imaging study Reviewed

    M Koeda, H Takahashi, N Yahata, M Matsuura, K Asai, Y Okubo, H Tanaka

    BIOLOGICAL PSYCHIATRY   59 ( 10 )   948 - 957   2006.5

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：ELSEVIER SCIENCE INC  

    Background: Neuroimaging studies have demonstrated either reduced left-lateralized activation or reversed language dominance in schizophrenia. These findings of left hemispheric dysfunction could be attributed to language processing tasks, which activate mainly left hemispheric function. Recent functional magnetic resonance imaging studies reported right-lateralized temporal activation by human voice perception, but few studies have investigated activation by human voice in schizophrenia. We aimed to clarify the cerebral function of language processing in schizophrenia patients by considering cerebral activation of human voice perception.
    Methods: Fourteen right-handed schizophrenia patients and 14 right-handed controls with matched handedness, sex, and education level were scanned by functional magnetic resonance imaging while listening to sentences (SEN), reverse sentences (rSEN), and identifiable non-vocal sounds (SND).
    Results: Under the SEN-SND and SEN-rSEN contrasts including language processing, patients showed less activation of the left hemisphere than controls in the language-related fronto-tempo-parietal region, hippocampus, thalamus and cingulate gyrus. Under the rSEN-SND contrast including human voice perception, patients showed less activation than controls in the right-lateralized temporal cortices and bilateral posterior cingulate.
    Conclusions: Our results indicate that schizophrenia patients have impairment of broader bilateral cortical-subcortical regions related to both the semantic network in the left hemisphere and the voice-specific network in the right hemisphere.

    DOI： 10.1016/j.biopsych.2006.01.013

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  • Effects of dopaminergic and serotonergic manipulation on emotional processing: A pharmacological fMRI study Reviewed

    H Takahashi, N Yahata, M Koeda, A Takano, K Asai, T Suhara, Y Okubo

    NEUROIMAGE   27 ( 4 )   991 - 1001   2005.10

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：ACADEMIC PRESS INC ELSEVIER SCIENCE  

    Recent neuroimaging studies have demonstrated abnormal central emotional processing in psychiatric disorders. The dopamine (DA) systems and serotonin (5-HT) systems are the main target of psychopharmacotherapy. DA D-2 receptor antagonists and selective serotonin reuptake inhibitors (SSRIs) are widely used in psychiatric practice. Investigating the effects of these drugs on emotional processing should lead to a better understanding of the pathophysiology and pharmacotherapy of neuropsychiatric disorders. We aimed to examine effects of dopaminergic and serotonergic manipulation on neural responses to unpleasant pictures in healthy volunteers using pharmacological fMRI.
    Thirteen healthy male subjects participated in a single-blind, randomized, placebo-controlled design study. Each subject participated in three fMRI sessions. In each session, participants were orally administered either 25 mg of sultopride or 50 mg of fluvoxamine or placebo prior to scanning, and neural responses to unpleasant and neutral pictures were recorded.
    Despite no significant differences being found in the subjective ratings of affective pictures across three sessions, compared to placebo, acute treatments of DA D2 receptor antagonists and SSRIs commonly attenuated the amygdala activity, although both treatments had slightly different modulatory effects on other components of the neural circuit of emotional processing. This study has shown that even acute treatment of drugs that manipulate neurotransmitter systems could affect brain activation associated with emotional processing in human brain. At the same time, our findings suggest that pharmacological fMRI could be a powerful tool for investigating the neurophysiological properties of drugs targeting neuropsychiatric disorders. (C) 2005 Elsevier Inc. All rights reserved.

    DOI： 10.1016/j.neuroimage.2005.05.039

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  • Brain activation associated with evaluative processes of guilt and embarrassment: an fMRI study Reviewed

    H Takahashi, N Yahata, M Koeda, T Matsuda, K Asai, Y Okubo

    NEUROIMAGE   23 ( 3 )   967 - 974   2004.11

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：ACADEMIC PRESS INC ELSEVIER SCIENCE  

    We aimed to investigate the neural substrates associated with evaluative process of moral emotions. Using functional magnetic resonance imaging (fMRI), we examined the similarities and differences between evaluative process of guilt and that of embarrassment at the neural basis level. Study of the neural basis of judgments of moral emotions might contribute to a better understanding of the amoral behavior observed in neurological and psychiatric disorders. Nineteen healthy volunteers were studied. The participants read sentences carrying neutral, guilty, or embarrassing contents during the scans. Both guilt and embarrassment conditions commonly activated the medial prefrontal cortex (MPFC), left posterior superior temporal sulcus (STS), and visual cortex. Compared to guilt condition, embarrassment condition produced greater activation in the right temporal cortex (anterior), bilateral hippocampus, and visual cortex. Most of these regions have been implicated in the neural substrate of social cognition or Theory of Mind (ToM). Our results support the idea that both are self-conscious emotions, which are social emotions requiring the ability to represent the mental states of others. At the same time, our functional fMRI data are in favor of the notion that evaluative process of embarrassment might be a more complex process than that of guilt. (C) 2004 Elsevier Inc. All rights reserved.

    DOI： 10.1016/j.neuroimage.2004.07.054

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  • An fMRI study of differential neural response to affective pictures in schizophrenia Reviewed

    H Takahashi, M Koeda, K Oda, T Matsuda, E Matsushima, M Matsuura, K Asai, Y Okubo

    NEUROIMAGE   22 ( 3 )   1247 - 1254   2004.7

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：ACADEMIC PRESS INC ELSEVIER SCIENCE  

    Although emotional dysfunction is considered a fundamental symptom of schizophrenia, studies investigating the neural basis of emotional dysfunction in schizophrenia are few. Using functional magnetic resonance imaging (fMRI) and a task viewing affective pictures, we aimed to examine automatic emotional response and to elucidate the neural basis of impaired emotional processing in schizophrenia. Fifteen healthy volunteers and 15 schizophrenics were studied. During the scans, the subjects were instructed to indicate how each of the presented pictures made them feel. Whole brain activities in response to the affective pictures were measured by fMRI. Controls recruited the neural circuit including amygdaloid-hippocampal region, prefrontal cortex, thalamus, basal ganglia, cerebellum, midbrain, and visual cortex while viewing unpleasant pictures. Despite an equal behavioral result to controls, the patients showed less activation in the components of the circuit (right amygdala, bilateral hippocampal region, medial prefrontal cortex (MPFC), basal ganglia, thalamus, cerebellum, midbrain, and visual cortex). This study demonstrated functional abnormalities in the neural circuit of emotional processing in schizophrenia. In particular, decreased activation in the right amygdala and MPFC appears to be an important finding related to dysfunctional emotional behavior in schizophrenia. (C) 2004 Elsevier Inc. All rights reserved.

    DOI： 10.1016/j.neuroimage.2004.03.028

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Books

  • Clinical pharmacology that helps you understand the “why?” of prescriptions

    Yasushi Imai（ Role： ContributorChapter 2: Specifics: Reorganize drug therapy for each disease; 8. Psychotropic drugs/sleep medication - Focusing on insomnia and depression -）

    Yodosha  2023.11  （ ISBN:9784758127080 ）

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    Total pages：271p   Language：Japanese  

    CiNii Books

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  • The Medical Frontline, a separate volume, ABC of Diagnosis and Treatment, No. 136, Schizophrenia

    KOEDA Michihiko（ Role： ContributorThe second chapter: Pathology: Evaluation for pathophysiology with functional neuroimaging in schizophrenia - from the evidence by fMRI and PET studies）

    Latest Medical Inc.  2018.6 

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    Responsible for pages：85-94  

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  • Ideal examination for dementia

    Satoshi Ueda（ Role： Contributor1. Pros and Cons: Drugs for Alzheimer’s Disease: Are They Effective, or not?, 2. Dementia with Lewy bodies）

    Igaku-Shoin Ltd.  2017  （ ISBN:9784260032216 ）

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    Responsible for pages：1. 194-206, 2. 230-237   Language：Japanese   Book type：Textbook, survey, introduction

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Misc.

  • The evaluation of placebo effects in the view of brain function Invited

    Michihiko Koeda

    Japanese Journal of Clinical Psychopharmacology   26 ( 9 )   859 - 865   2023.9

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    Authorship：Lead author   Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

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  • 4大精神疾患の大脳構造の類似度の解析 大脳皮質厚と大脳皮質表面積の多施設共同疾患横断解析

    松本 純弥, 福永 雅喜, 三浦 健一郎, 根本 清貴, 岡田 直大, 橋本 直樹, 森田 健太郎, 越山 太輔, 大井 一高, 高橋 努, 肥田 道彦, 山森 英長, 藤本 美智子, 安田 由華, 伊藤 颯姫, 山崎 龍一, 長谷川 尚美, 成田 尚, 横山 仁史, 三嶋 亮, 宮田 淳, 小林 祐子, 笹林 大樹, 原田 健一郎, 山本 真江里, 平野 羊嗣, 板橋 貴史, 中瀧 理仁, 橋本 龍一郎, タ・キンキン, 小池 進介, 松原 敏郎, 岡田 剛, 吉村 玲児, 阿部 修, 鬼塚 俊明, 渡邊 嘉之, 松尾 幸治, 山末 英典, 岡本 泰昌, 鈴木 道雄, 尾崎 紀夫, 笠井 清登, 橋本 亮太

    国立精神・神経医療研究センター精神保健研究所年報   ( 36 )   210 - 210   2023.7

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    Language：Japanese   Publisher：(国研)国立精神・神経医療研究センター精神保健研究所  

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  • 4大精神疾患の大脳構造の類似度の解析 大脳皮質厚と大脳皮質表面積の多施設共同疾患横断解析

    松本 純弥, 福永 雅喜, 三浦 健一郎, 根本 清貴, 岡田 直大, 橋本 直樹, 森田 健太郎, 越山 太輔, 大井 一高, 高橋 努, 肥田 道彦, 山森 英長, 藤本 美智子, 安田 由華, 伊藤 颯姫, 山崎 龍一, 長谷川 尚美, 成田 尚, 横山 仁史, 三嶋 亮, 宮田 淳, 小林 祐子, 笹林 大樹, 原田 健一郎, 山本 真江里, 平野 羊嗣, 板橋 貴史, 中瀧 理仁, 橋本 龍一郎, タ・キンキン, 小池 進介, 松原 敏郎, 岡田 剛, 吉村 玲児, 阿部 修, 鬼塚 俊明, 渡邊 嘉之, 松尾 幸治, 山末 英典, 岡本 泰昌, 鈴木 道雄, 尾崎 紀夫, 笠井 清登, 橋本 亮太

    国立精神・神経医療研究センター精神保健研究所年報   ( 36 )   210 - 210   2023.7

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  • Behavioral and psychological symptoms of dementia and change of default mode network based on tau pathology Invited

    Michihiko Koeda, Amane Tateno, Yoshiro Okubo

    Community-based care system   25 ( 4 )   43 - 46   2023.4

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  • Biomarker of Neuroimaging: fMRI: default-mode network and neural basis on dementia based on cerebral circuit of tau pathology Invited

    Michihiko Koeda

    Cefiro   35   13 - 16   2022.6

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    Authorship：Lead author   Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

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  • Aberrant of default mode network based on tau pathology and behavioral and psychological symptoms of dementia Invited

    Michihiko Koeda, Amane Tateno, Yoshiro Okubo

    Chiiki Caring   24 ( 5 )   84 - 87   2022.5

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    Authorship：Lead author   Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

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  • Functional Neuroimaging of Auditory Linguistic and Vocal Affective Processing for Diagnosis and Treatment of Psychiatric Disorders Invited

    Michihiko Koeda

    Nihon Ika Daigaku Igakkai Zasshi   18 ( 1 )   72 - 85   2022.2

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    Authorship：Lead author   Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)   Publisher：Medical Association of Nippon Medical School  

    DOI： 10.1272/manms.18.72

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  • A review of suicide-related brain circuit and functional neuroimaging Invited

    Michihiko Koeda

    50 ( 6 )   585 - 593   2021.6

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    Authorship：Lead author   Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

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  • Impairment of default mode network based on tau pathology and behavioral and psychological symptoms of dementia Invited

    Michihiko Koeda, Amane Tateno, Yoshiro Okubo

    Community-based care system   23 ( 5 )   52 - 55   2021.5

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    Authorship：Lead author   Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

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  • Clarifi cation of the impairment of default mode network due to tau-pathology pathway for behavior problems of dementia Invited

    Michihiko Koeda, Amane Tateno, Yoshiro Okubo

    Cell   53 ( 1 )   64 - 67   2021.1

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    Authorship：Lead author   Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

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  • Brain structure and functional neuroimaging in anxiety disorders by using functional MRI

    Michihiko Koeda

    Journal of clinical and experimental medicine (IGAKU NO AYUMI)   270 ( 9 )   801 - 808   2019.8

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    Authorship：Lead author   Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

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  • The placebo effect in brain: based on the scientific evidence of functional neuroimaging with PET and fMRI Invited

    Michihiko Koeda

    Psychiatry   35 ( 1 )   35 - 40   2019.7

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    Authorship：Lead author   Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

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  • Evaluation by neuroimaging during vocal social recognition in schizophrenia: An fMRI study on cerebral activation in the recognition of attractiveness prosody

    Michihiko Koeda

    Japanese Journal of Biological Psychiatry   30 ( 2 )   67 - 72   2019.6

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  • 経頭蓋直流刺激による安静時機能的MRI施行時の機能的結合に対する影響:予備的fMRI研究

    肥田道彦, 濱智子, 中島創一郎, 秋山友美, 池田裕美子, 舘野周, 鈴木秀典, 大久保善朗

    日本生物学的精神医学会(Web)   41st   2019

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  • 経頭蓋直流刺激による言語流暢性課題施行時の脳賦活に対する影響:予備的fMRI研究

    中島創一郎, 肥田道彦, 濱智子, 秋山友美, 池田裕美子, 舘野周, 鈴木秀典, 大久保善朗

    日本生物学的精神医学会(Web)   41st   2019

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  • 近赤外線分光法(NIRS)によるうつ病の左前頭葉活動の低下

    木村 真人, 秋山 友美, 肥田 道彦, 下田 健吾

    Journal of International Society of Life Information Science   36 ( 2 )   111 - 111   2018.9

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    Language：Japanese   Publisher：国際生命情報科学会 ISLIS本部  

    J-GLOBAL

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  • 【診断と治療のABC[136]統合失調症】 (第2章)病態 脳機能画像を用いた統合失調症の病態評価 fMRI・PETによる知見を中心に

    肥田 道彦

    最新医学   別冊 ( 統合失調症 )   85 - 94   2018.7

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    Language：Japanese   Publisher：(株)最新医学社  

    近年、脳機能画像を用いた統合失調症の臨床症状の評価や抗精神病薬の薬効評価が行われている。本稿では、認知行動関連・脳機能画像研究と分子イメージング研究に分け、前者については情動や言語課題を用いた機能的磁気共鳴画像(fMRI)研究や安静時fMRI研究、後者については脳神経伝達機能やトランスポーターに特異的なトレーサーを用いたポジトロン断層撮影(PET)に関する研究を中心に、研究手法の概略と実際の研究内容の紹介を行った。(著者抄録)

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  • 声に含まれる好意的プロソディー認知時の前頭側頭の機能的結合に関する統合失調症fMRI研究

    肥田 道彦, 高橋 英彦, 浅井 邦彦, 大久保 善朗

    精神神経学雑誌   ( 2018特別号 )   S520 - S520   2018.6

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  • Change of Cerebral Function Before and After m-ECT in Patients with Mood Disorder:A Preliminary NIRS Study

    Kimura Mahito, Akiyama Tomomi, Koeda Michihiko, Shimoda Kengo

    Journal of International Society of Life Information Science   36 ( 1 )   26 - 27   2018.3

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    Background: Near-infrared spectroscopy (NIRS) is used as a clinically convenient application to evaluate pathophysiology in mood disorders. Modified electroconvulsive therapy (m-ECT) is used as one choice of the treatment for severe depression and treatment-resistant depression, but to our knowledge, few studies have investigated the m-ECT effect on cerebral function. Aim: We intended to investigate the therapeutic effect of m-ECT for mood disorders by NIRS. Methods: Based on the approved protocol by the ethics committee, fronto-temporal activity of 13 patients with mood disorders were evaluated during a verbal fluency procedure before and after m-ECT with NIRS. After a complete explanation of the study, written informed consent was obtained from all subjects. Patients with mood disorder were classified into one group with 6 depression patterns (D-pattern group) and a second group with 7 manic-depressive patterns (MDI-pattern group) by the frontal lobe mean oxy-hemoglobin pattern based on a previous NIRS study (Takizawa et al., 2014). Results: Depressed state in all 13 subjects was mitigated after m-ECT. Temporal lobe activity in both D-pattern group and MDI-pattern group significantly increased after m-ECT compared to before m-ECT. Frontal lobe activity in the MDI pattern group was much improved after m-ECT compared to frontal lobe activity in the D-pattern group. In the MDI pattern group, the mean of the frontal lobe activity after m-ECT was significantly greater than before m-ECT at the bilateral middle frontal region and the left orbitofrontal region. Conclusion: Our results suggest that temporal lobe activity increases in both D-pattern group and MDI-pattern group, but the frontal lobe activity increases only in MDI pattern group during the verbal fluency task as seen by NIRS after m-ECT accompanied by mitigation of the depressive state.

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  • ブプロピオンによる聴覚情動認知・機能的結合に対する効果:fMRI研究

    濱智子, 肥田道彦, 池田裕美子, 舘野周, 鈴木秀典, 大久保善朗

    日本ヒト脳機能マッピング学会プログラム・抄録集   20th   79   2018

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  • うつ病患者における言語流暢性課題施行時の左背外側前頭前野の機能低下に関する光トポグラフィ研究

    秋山友美, 秋山友美, 肥田道彦, 大久保善朗, 木村真人

    日本ヒト脳機能マッピング学会プログラム・抄録集   20th   2018

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  • 踏み台昇降を用いた高齢者うつ病に対する運動療法の予備的研究

    永田恵理香, 秋山友美, 太田杏奈, 鈴木清人, 肥田道彦, 池森紀夫, 下田健吾, 木村真人

    催眠と科学   30/31 ( 1 )   2018

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  • 若年性統合失調症に対し、アリピプラゾール持続型注射剤が奏功した一例

    藤本 泰樹, 野上 毅, 肥田 道彦, 成重 竜一郎, 舘野 周, 大久保 善朗

    精神神経学雑誌   119 ( 10 )   802 - 802   2017.10

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  • ブプロピオンの情動認知時脳賦活に与える影響 予備的fMRI研究

    肥田 道彦, 濱 智子, 池田 裕美子, 舘野 周, 鈴木 秀典, 大久保 善朗

    日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集   39回・47回   154 - 154   2017.9

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    Language：Japanese   Publisher：日本生物学的精神医学会・日本神経精神薬理学会  

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  • 音声情動認知時の機能的結合に対するブプロピオンの効果 予備的fMRI研究

    濱 智子, 肥田 道彦, 池田 裕美子, 舘野 周, 鈴木 秀典, 大久保 善朗

    日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集   39回・47回   164 - 164   2017.9

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    Language：Japanese   Publisher：日本生物学的精神医学会・日本神経精神薬理学会  

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  • 痛みの声を聴いたときの脳活動

    冨澤 大佑, 山崎 陽子, 嶋田 昌彦, 肥田 道彦, 舘野 周, 大久保 善朗

    日本慢性疼痛学会プログラム・抄録集   46回   60 - 60   2017.2

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  • ロラゼパム投与時の不安軽減度と恐怖感情認知脳内ネットワークの分布の関連:機能的MRI研究

    肥田道彦, 長谷武志, 濱智子, 濱智子, 池田裕美子, 舘野周, 鈴木秀典, 大久保善朗

    日本臨床精神神経薬理学会プログラム・抄録集   27th   119   2017

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  • 前頭側頭葉変性症9例における[11C]PBB3 PETを用いた脳内タウ集積の検討

    丹羽 文俊, 島田 斉, 高畑 圭輔, 篠遠 仁, 遠藤 浩信, 北村 聡一郎, 平野 成樹, 木村 泰之, 樋口 真人, 須原 哲也, 肥田 道彦, 田渕 肇, 三村 將

    臨床神経学   56 ( Suppl. )   S279 - S279   2016.12

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  • 【[改訂版]精神科・わたしの診療手順】(第18章)神経認知障害群 パーキンソン関連疾患に伴う精神症状

    肥田 道彦

    臨床精神医学   45 ( 増刊 )   475 - 479   2016.12

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  • 恐怖音声認知・脳処理時の機能的結合に対するプラセボ・ロラゼパムの効果 機能的MRI研究

    肥田 道彦, 長谷 武志, 濱 智子, 池田 裕美子, 八幡 憲明, 舘野 周, 高橋 英彦, 松浦 雅人, 鈴木 秀典, 大久保 善朗

    日本神経精神薬理学会年会プログラム・抄録集   46回   215 - 215   2016.7

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  • 気分障害に対する診断と治療の最前線 NIRSによる気分障害の病態研究 うつ状態の病態比較とmECT前後の前頭側頭機能比較

    肥田 道彦, 秋山 友美, 下田 健吾, 木村 真人, 大久保 善朗

    総合病院精神医学   28 ( 3 )   275 - 275   2016.7

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  • 軽度認知機能障害患者の顔認知時の脳機能に関する予備的検討 機能的MRI研究

    肥田 道彦, 舘野 周, 大久保 善朗

    老年精神医学雑誌   27 ( 増刊II )   172 - 172   2016.6

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  • PHQ-9によるうつ病評価とNIRSによる前頭側頭機能評価の関連

    肥田 道彦, 秋山 友美, 永田 恵理香, 太田 杏奈, 池森 紀夫, 下田 健吾, 木村 真人, 大久保 善朗

    精神神経学雑誌   112th ( 2016特別号 )   S624 - S624   2016.6

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  • 難治性うつ状態に電気けいれん療法が有効であったアミロイド関連うつ病の一例 3年の長期入院からの回復

    小林 まどか, 明野 薫, 肥田 道彦, 上田 諭, 舘野 周, 大久保 善朗

    老年精神医学雑誌   27 ( 増刊II )   168 - 168   2016.6

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  • 近赤外線スペクトロスコピーを用いたm-ECT治療前後の気分障害患者の前頭側頭波形パターンに関する予備的検討

    肥田 道彦, 秋山 友美, 永田 恵理香, 太田 杏奈, 内山 翔太郎, 岩本 康夫, 安田 毅, 鈴木 清人, 新貝 慈利, 池森 紀夫, 下田 健吾, 木村 真人

    総合病院精神医学   28 ( 1 )   55 - 56   2016.1

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  • プラセボ・ロラゼパム投与時の恐怖感情認知脳内ネットワークと不安軽減度の関連:機能的MRI研究

    肥田道彦, 長谷武志, 長谷武志, 濱智子, 濱智子, 池田裕美子, 八幡憲明, 舘野周, 高橋英彦, 松浦雅人, 鈴木秀典, 大久保善朗

    日本生物学的精神医学会(Web)   38th   60 (WEB ONLY)   2016

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  • EFFECT OF CNTNAP2 POLYMORPHISMS ON CEREBRAL RESPONSE TO HUMAN VOICE PERCEPTION AND HANDEDNESS: AN FMRI STUDY Reviewed

    Michihiko Koeda, Atsushi Watanabe, Kumiko Tsuda, Miwako Matsumoto, Yumiko Ikeda, Woochan Kim, Amane Tateno, Banyar Than Naing, Hiroyuki Karibe, Takashi Shimada, Hidenori Suzuki, Masato Matsuura, Yoshiro Okubo

    JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY   86 ( 9 )   2015.9

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    DOI： 10.1136/jnnp-2015-311750.64

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  • 近赤外線スペクトロスコピーを用いた気分障害に対するm-ECT治療前後の脳機能変化に関する予備的検討

    肥田 道彦, 秋山 友美, 永田 恵理香, 太田 杏奈, 安田 毅, 新貝 慈利, 鈴木 清人, 池森 紀夫, 下田 健吾, 木村 真人

    精神神経学雑誌   111th ( 2015特別 )   S327 - S327   2015.6

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  • CEREBRAL RESPONSE TO NONVERBAL AFFECTIVE VOCALIZATIONS AND CROSS-CULTURAL DIFFERENCES BY ASIAN AND CAUCASIAN LISTENERS: AN FMRI STUDY

    M. Koeda, D. Fleming, Y. Okubo, P. Belin

    AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY   49   87 - 87   2015.5

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  • Cross-cultural differences in the processing of fearful and painful vocalizations by Japanese and Canadian listeners

    M. Koeda, P. Belin, T. Hama, T. Matsuda, M. Matsuura, Y. Okubo

    PSYCHOTHERAPY AND PSYCHOSOMATICS   84   40 - 40   2015

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  • 非言語性感情音声聴取時の脳賦活に対するマジンドールの効果 fMRI研究

    肥田 道彦, 池田 裕美子, 舘野 周, 鈴木 秀典, 大久保 善朗

    日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集   24回・44回   160 - 160   2014.11

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  • 人の声に選択的な脳賦活部位に対するCNTNAP2多型の影響:機能的MRI研究

    肥田道彦, 渡辺淳, 池田裕美子, キム ウーチャン, 舘野周, 苅部洋行, 鈴木秀典, 松浦雅人, 大久保善朗

    日本生物学的精神医学会誌   384   2014

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  • CULTURAL EFFECTS ON THE PERCEPTION OF NON-LINGUISTIC AFFECTIVE VOCALISATION BY JAPANESE AND CANADIAN SUBJECTS

    M. Koeda, P. Belin, T. Hama, T. Masuda, M. Matsuura, Y. Okubo

    JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY   83 ( 10 )   2012.10

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    DOI： 10.1136/jnnp-2012-303538.27

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  • Effects of sports participation on psychiatric symptoms and brain activations during sports observation in schizophrenia

    H. Takahashi, T. Sassa, T. Shibuya, M. Kato, M. Koeda, T. Murai, M. Matsuura, K. Asai, T. Suhara, Y. Okubo

    TRANSLATIONAL PSYCHIATRY   2   2012.3

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    Weight gain has been identified as being responsible for increased morbidity and mortality rates of schizophrenia patients. For the management of weight gain, exercise is one of the most acknowledged interventions. At the same time, exercise and sports have been recognized for their positive impact on psychiatric symptoms of schizophrenia. However, the neurobiological basis for this remains poorly understood. We aimed to examine the effect of sports participation on weight gain, psychiatric symptoms and brain activation during sports observation in schizophrenia patients. Thirteen schizophrenia patients who participated in a 3-month program, including sports participation and 10 control schizophrenia patients were studied. In both groups, body mass index (BMI), Positive and Negative Syndrome Scale (PANSS), and brain activation during observation of sports-related actions measured by functional magnetic resonance imaging were accessed before and after a 3-month interval. BMI and general psychopathology scale of PANSS were significantly reduced in the program group but not in the control group after a 3-month interval. Compared with baseline, activation of the body-selective extrastriate body area (EBA) in the posterior temporal-occipital cortex during observation of sports-related actions was increased in the program group. In this group, increase in EBA activation was associated with improvement in the general psychopathology scale of PANSS. Sports participation had a positive effect not only on weight gain but also on psychiatric symptoms in schizophrenia. EBA might mediate these beneficial effects of sports participation. Our findings merit further investigation of neurobiological mechanisms underlying the therapeutic effect of sports for schizophrenia. Translational Psychiatry (2012) 2, e96; doi:10.1038/tp.2012.22; published online 20 March 2012

    DOI： 10.1038/tp.2012.22

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  • Caffeine effects on attentional networks: a pharmacological fMRI study Reviewed

    Yumiko Ikeda, Michihiko Koeda, Woochan Kim, Noriaki Yahata, Hidehiko Takahashi, Amane Tateno, Yoshiro Okubo, Hidenori Suzuki

    JOURNAL OF PHARMACOLOGICAL SCIENCES   118   263P - 263P   2012

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  • Modafinil使用時の音声情動認知の脳活動に関するfunctional MRI研究

    長濱健一郎, 戸田由美子, 肥田道彦, 池田裕美子, 舘野周, 鈴木秀典, 大久保善朗

    日本精神科診断学会プログラム・抄録集   32nd   114   2012

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  • Delirium induced by lafutidine, histamine H2-receptor antagonist in three postoperative cancer patients

    上田 諭, 肥田 道彦, 大久保 善朗

    Japanese journal of clinical psychiatry   40 ( 10 )   1359 - 1363   2011.10

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  • 精神疾患の臨床病態評価に向けた音声感情認知評価法の開発

    長濱 健一郎, 戸田 由美子, 原 真由美, 野々垣 香織, 園木 健太郎, 肥田 道彦, 舘野 周, 大久保 善朗

    日本医科大学医学会雑誌   7 ( 4 )   224 - 224   2011.10

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    DOI： 10.1272/manms.7.224

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  • A case with organic amnesic disorder syndrome diagnosed by fMRI

    肥田 道彦, 滝沢 勇一, 皆川 薫

    Japanese journal of clinical psychiatry   40 ( 10 )   1347 - 1351   2011.10

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  • Effects of caffeine on attentional networks in healthy individuals: A pharmacological fMRI study Reviewed

    Yumiko Ikeda, Michihiko Koeda, Woochan Kim, Noriaki Yahata, Hidehiko Takahashi, Amane Tateno, Yoshiro Okubo, Hidenori Suzuki

    NEUROSCIENCE RESEARCH   71   E174 - E174   2011

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    DOI： 10.1016/j.neures.2011.07.754

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  • Stroop課題関連の脳活動に対するcaffeineの効果―fMRlによるドーピング効果の検出―

    金禹瑣, 池田裕美子, 肥田道彦, 高橋英彦, 舘野周, 鈴木秀典, 大久保善朗

    日本生物学的精神医学会誌   21 ( Supplement )   101   2010.10

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  • 聴覚情動処理時の脳活動に対するカフェインの効果 機能的MRI研究

    渡部 友香理, 肥田 道彦, 金 禹叙, 池田 裕美子, 鈴木 秀典, 大久保 善朗, 田中 博

    臨床神経生理学   38 ( 5 )   354 - 354   2010.10

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  • 聴覚作動性記憶時の脳活動に対するカフェインの効果 機能的MRI研究

    肥田 道彦, 渡部 友香理, キム・ウーチャン, 池田 裕美子, 鈴木 秀典, 田中 博, 大久保 善朗

    臨床神経生理学   38 ( 5 )   354 - 354   2010.10

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  • 器質性気分障害が疑われた若年女性の1例

    山岡 宣行, 西條 朋行, 金 禹さん, 上田 諭, 肥田 道彦, 岸 泰宏, 齋藤 卓弥, 大久保 善朗

    精神神経学雑誌   112 ( 9 )   945 - 945   2010.9

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  • Psychoeducation for patients with dementia

    肥田 道彦, 野原 将英, 浅井 邦彦

    Japanese journal of clinical psychiatry   39 ( 6 )   759 - 763   2010.6

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  • H2ブロッカーlafutidineによる術後せん妄

    上田 諭, 肥田 道彦, 舘野 周, 大久保 善朗

    老年精神医学雑誌   21 ( 増刊II )   158 - 158   2010.6

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  • A case of catatonia successfully treated with combined benzodiazepine and electroconvulsive therapy using flumazenil, a benzodiazepine-competitive antagonist, as preanesthetic medication

    宮吉 孝明, 藤渡 辰馬, 肥田 道彦

    Japanese journal of clinical psychiatry   38 ( 9 )   1397 - 1403   2009.9

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  • Auditory selective attention as revealed by a diotic listening task: an fMRI study

    Yumiko Ikeda, Noriaki Yahata, Hidehiko Takahashi, Michihiko Koeda, Yoshiro Okubo, Hidenori Suzuki

    NEUROSCIENCE RESEARCH   65   S239 - S239   2009

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    DOI： 10.1016/j.neures.2009.09.1351

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  • Cerebral response to social interaction including human voice in schizophrenia : an fMRI study

    KOEDA Michihiko

    脳と精神の医学 = Brain science and mental disorders   19 ( 4 )   237 - 244   2008.12

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  • A functional MRI study: Cerebral activation for human voice inflexion in schizophrenia

    M. Koeda, H. Takahashi, N. Yahata, K. Asai, M. Matsuura, H. Tanaka, Y. Okubo

    JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY   79 ( 8 )   974 - 975   2008.8

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  • fMRI studies on auditory language processing and human voice perception in schizophrenia

    肥田 道彦

    Japanese journal of clinical psychiatry   37 ( 6 )   751 - 758   2008.6

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  • Cerebral response to recognition of the inflexion in human voice: A functional MRI study

    M. Koeda, M. Matsuura, H. Takahashi, Y. Okubo, H. Tanaka

    JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY   78 ( 7 )   785 - 785   2007.7

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  • A case of Fahr's Disease with Anorexia Nervosa

    Koeda Michihiko, Saito Takuya, Okubo Yoshiro

    Nihon Ika Daigaku Igakkai Zasshi   2 ( 4 )   202 - 205   2006

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    We report a case of anorexia nervosa with familial idiopathic basal ganglia calcification (IBGC, Fahr's disease). A 30-year-old woman with anorexia nervosa was brought to the Department of Critical Care Medicine because of severe weight loss and dehydration. Imaging studies revealed bilaterally symmetrical calcifications in the caudate nucleus, putamen, globus pallidus, and thalamus, and Fahr's disease was diagnosed. Fahr's disease sometimes has comorbid psychiatric conditions, such as schizophrenia and personality changes, but this is the first case of Fahr's disease with anorexia nervosa. This case illustrates the importance of comprehensive medical assessment for psychiatric patients admitted for the first time.<br>

    DOI： 10.1272/manms.2.202

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  • 階層分析法の医療技術評価への応用における問題点の解決方法に関する研究

    柴田健雄, 肥田道彦, 清水洋子

    医療情報学連合大会論文集   25th   1179 - 180   2005.11

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  • 痴呆患者家族の介護方針に関する心理構造の評価

    肥田道彦, 柴田健雄, 浅井邦彦, 田中博

    医療情報学連合大会論文集   24th   884 - 885   2004.11

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  • 階層分析法を利用した満足度評価における整合度改善のための数理的アプローチ

    柴田健雄, 肥田道彦, 田中博

    医療情報学連合大会論文集   23rd   458 - 459   2003.11

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  • 痴呆患者家族の介護方針に関連した心理的背景因子の評価法の改良及びその有用性の検討

    肥田道彦, 柴田健雄, 浅井邦彦, 田中博

    医療情報学連合大会論文集   23rd   455 - 457   2003.11

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  • 精神疾患における脳の画像解析学的研究 PET,MRIを用いた統合失調症の研究

    大久保 善朗, 須原 哲也, 肥田 道彦, 高野 晶寛, 高橋 英彦, 安野 史彦, 一宮 哲哉, 浅井 禎之, 織田 健司, 池田 裕美子, 室田 亜希子, 中山 貴至, 伊藤 滋朗, 西條 朋行, 生駒 洋子, 前田 純, 田中 博, 浅井 邦彦

    厚生労働省精神・神経疾患研究委託費研究報告集   平成14年度   503 - 503   2003.6

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  • 選択的聴取のfMRI解析

    池田 裕美子, 室田 亜希子, 肥田 道彦, 高橋 英彦, 織田 健司, 大久保 善朗

    臨床神経生理学   31 ( 2 )   181 - 181   2003.4

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  • 聴覚刺激を用いた情動反応の解析

    室田 亜希子, 池田 裕美子, 肥田 道彦, 高橋 英彦, 織田 健司, 大久保 善朗

    臨床神経生理学   31 ( 2 )   182 - 182   2003.4

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  • 痴呆患者の家族における介護支援の方針決定に関する心理的背景因子の評価

    肥田道彦, 柴田健雄, 浅井邦彦, 大久保善朗, 田中博

    日本社会精神医学会プログラム・抄録集   23rd   107   2003

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  • 痴呆患者の家族における介護支援の方針決定に関する心理的背景因子の評価

    肥田道彦, 柴田健雄, 浅井邦彦, 田中博

    医療情報学連合大会論文集   22nd   125 - 126   2002.11

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  • 歌の認知のfMRI

    肥田道彦, 高橋英彦, 室田亜希子, 池田裕美子, 織田健司, 浅井邦彦, 大久保善朗, 田中博

    情報計算化学生物学会大会論文集   3rd   316 - 317   2002.9

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  • PET,MRIを用いた精神分裂病の研究

    大久保 善朗, 須原 哲也, 高橋 英彦, 高野 晶寛, 安野 史彦, 一宮 哲哉, 浅井 禎之, 肥田 道彦, 織田 健司, 室田 亜希子, 中山 貴至, 伊藤 滋朗, 西條 朋行, 浅井 邦彦

    厚生労働省精神・神経疾患研究委託費総括研究報告書 精神疾患の生理学的・画像解析学的研究   平成11〜13年度   11,56 - 60   2002.3

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    Language：Japanese   Publisher：厚生労働省精神・神経疾患研究班  

    リスペリドン服用中の精神分裂病患者4例を対象とし,線条体外ドーパミンD2受容体占有率の経時的変化を調べた.又,精神分裂病患者13例と健康人13例を対象に,MRIを用いて視覚刺激による情動反応の評価を行った.リスペリドンでは血中濃度の減少に比し,大脳皮質ドーパミンD2受容体占有率の減少の程度は少なく,血中濃度が低下しても脳内では高い受容体占有率が維持されていた.分裂病群では,不快刺激に対する脳血流増加が低下し,分裂病における情動鈍麻やアンヘドニアに対応する所見と思われた

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Presentations

  • Current status and issues of support for returning to work during the coronavirus pandemic at our hospital

    Michihiko Koeda, Saho Wada, Eri Inamoto, Maya Fukugawa

    36th General Meeting of the Japanese Society of General Hospital Psychiatry  2023.11 

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    Event date： 2023.11

    Language：Japanese   Presentation type：Poster presentation  

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  • Cross-cultural differences of cerebral response to non-verbal auditory affective processing: An fMRI study

    Michihiko Koeda

    The 45th Annual Meeting of the Japanese Society of Biological Psychiatry  2023.11 

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    Event date： 2023.11

    Language：Japanese   Presentation type：Poster presentation  

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  • Effects of modafinil and bupropion on vocal affective processing and brain activity: a functional MRI study

    Michihiko Koeda, Tomoko Hama, Yumiko Ikeda, Hidenori Suzuki, Yoshiro Okubo, Amane Tateno

    The 33rd Annual Meeting of the Japanese Society of Clinical Neuropsychopharmacology  2023.9 

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    Event date： 2023.9

    Language：Japanese   Presentation type：Oral presentation (general)  

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  • Functional association between dopamine transporter density and salience network

    Michihiko Koeda

    The 41st annual meeting of Japanese society of dementia and the 37th annual meeting of Japanese society of geriatric psychiatry  2022.11 

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    Event date： 2022.11

    Language：Japanese   Presentation type：Poster presentation  

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  • Association between dopamine transporter density and dopamine related brain network

    Michihiko Koeda

    Japanese contract symposium on the society of biological psychiatry, clinical neuropsychopharmacology, neuropsychopharmacology, psychiatric pharmacy  2022.11 

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    Event date： 2022.11

    Language：Japanese   Presentation type：Poster presentation  

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  • Consultation-liaison psychiatry on pandemic period of covid-19 in Nippon Medical School Tama-Nagayama Hospital

    Michihiko Koeda

    The 35th annual meeting of Japanese society of general hospital psychiatry  2022.10 

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    Event date： 2022.10

    Language：Japanese   Presentation type：Poster presentation  

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  • evaluation of neural basis on language-related processing in the patients with Asperger's syndrome and depressive symptom

    Michihiko Koeda, Akihiro Kumagai, Saori Oshima, Yoko Nioka, Tatsuya Tokuda, Teruyo Doi, Atsushi Sawaya, Kengo Shimoda, Ippeita Dan, Mahito Kimura

    The 34th Annual Meeting of the Japanese Society of General Hospital Psychiatry  2021.12 

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    Event date： 2021.11 - 2021.12

    Language：Japanese   Presentation type：Oral presentation (general)  

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  • The effect of modafinil and bupropion to cerebral response to emotional voca lizations: A pharmacological functional MRI study

    Michihiko Koeda, Tomoko Hama, Yumiko Ikeda, Amane Tateno, Hidenori Suzuki, Yoshiro Okubo

    The 43rd Annual Meeting of the Japanese Society of Biological Psychiatry; The 51st Annual Meeting of the Japanese Society of Neuropsychopharmacology  2021.7 

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    Event date： 2021.7

    Language：Japanese   Presentation type：Oral presentation (general)  

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  • The influence to functional connectivity of resting state fMRI by transcranial direct-current stimulation: A preliminary fMRI study

    MIchihiko Koeda, Tomoko Hama, Soichiro Nakashima, Yomiko Ikeda, Amane Tateno, Hidenori Suziki, Yoshiro Okubo

    The 41st Annual Meeting of Japanese Society of Biological Psychiatry  2019.6 

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    Event date： 2019.6

    Language：Japanese   Presentation type：Oral presentation (general)  

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  • Evaluation of emotional processing by using non-verbal affective vocalization in depressive patients: A preliminary study

    Michihiko Koeda, Ai Nagamine, Tokuhiro Kawara, Yoshiro Okubo

    The 115th Annual Meeting of the Japanese Society of Psychiatry and Neurology  2019.6 

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    Event date： 2019.6

    Language：Japanese   Presentation type：Oral presentation (general)  

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  • Bupropion effect on affective network and subjective emotional evaluation

    Hama T, Koeda M, Ikeda Y, Tateno A, Kawara T, Suzuki H, Okubo Y

    The 25th Organization for Human Brain Mapping Annual Meeting  2019.6 

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    Event date： 2019.6

    Language：Japanese   Presentation type：Oral presentation (general)  

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  • Functional correlation between mesolimbic network & dopamine transporter density: An fMRI-PET study

    Koeda M, Ozawa S, Tomoko H, Moriya H, Sakayori T, Tateno A, and Okubo Y

    The 25th Organization for Human Brain Mapping Annual Meeting  2019.6 

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    Event date： 2019.6

    Language：English   Presentation type：Oral presentation (general)  

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  • Frontotemporal functional connectivity in the recognition of positive prosody in schizophrenia: An fMRI study

    KOEDA Michihiko, TAKAHASHI hidehiko, ASAI kunihiko, OKUBO yoshiro

    The 114th Annual Meeting of the Japanese Society of Psychiatry and Neurology  2018.6 

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  • Frontotemporal functional connectivity in recognition of vocal attractiveness in schizophrenia: An fMRI study International conference

    Michihiko Koeda, Hidehiko Takahashi, Kunihiko Asai, Yoshiro Okubo

    The British Neuropsychiatry Association - 31st AGM  2018.3 

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    Language：English   Presentation type：Poster presentation  

    Venue：Kings Place, London, UK  

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  • Frontotemporal functional connectivity in recognition of vocal attractiveness and hallucinatory behavior: An fMRI study International conference

    KOEDA Michihiko

    The 4th International Consortium Meeting on Hallucination Research  2017.11  "Nouveau Siecle" meeting center, Lille, France

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    Language：English   Presentation type：Oral presentation (general)  

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  • ロラゼパム投与時の不安軽減度と恐怖感情認知脳内ネットワークの関連：機能的MRI研究

    肥田 道彦

    第27回日本臨床精神神経薬理学会  2017.11 

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    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：松江テルサ、島根  

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  • The influence of handedness and BDNF Val157Met on Cerebral Responses to Language Processing and Human Voice Perception

    KOEDA Michihiko

    the 40th Annual Meeting of Japanese Society of Biological Psychiatry  2018.9 

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    Language：Japanese   Presentation type：Oral presentation (general)  

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  • The symposium on Current status of hallucination and delusion research: Evaluation for hallucinatory behavior by analysis of functional brain-connectivity in the recognition of emotional prosody in schizophrenia

    KOEDA Michihiko

    the 40th Annual Meeting of Japanese Society of Biological Psychiatry  2018.9 

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    Language：English   Presentation type：Symposium, workshop panel (public)  

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  • Symposium on Neurophysiology: Hallucinatory behavior and functional connectivity in the recognition of vocal attractiveness in schizophrenia International conference

    KOEDA Michihiko

    International Consortium on Hallucination Research and related symptoms Kyoto Satellite Meeting  2018.10 

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    Language：English   Presentation type：Symposium, workshop panel (nominated)  

    Venue：Kyoto University Clock Tower, Kyoto, Japan  

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  • The effect of modafinil and bupropion on cerebral response to vocal affective processing: A pharmacological MRI study

    Michihiko Koeda

    The 28th Organization for Human Brain Mapping Annual Meeting, Jun 7-8, 2022  2022.6 

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    Language：English   Presentation type：Poster presentation  

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  • fMRI in Psychiatric Research Invited

    Michihiko Koeda

    Online seminar at Center for Information and Neural Networks  2020.7 

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    Language：English   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

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  • Evaluation of neural basis on language processing of Autism Spectrum Disorders with depressive symptoms

    Michihiko Koeda

    The 118th Annual Meeting of the Japanese Society of Psychiatry and Neurology  2022.6 

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  • 統合失調症の選択的音声感受領域の脳病態とFOXP2関連遺伝子の影響に関する検討

    肥田 道彦

    第38回日本生物学的精神医学会：第5回若手研究者育成プログラム最優秀奨励賞選考  2016.9 

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    Language：Japanese  

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  • プラセボ・ロラゼパム投与時の恐怖感情認知ネットワークと不安軽減度の関連：機能的MRI研究

    肥田 道彦

    第38回日本生物学的精神医学会  2016.9 

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    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：福岡国際会議場、福岡  

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  • Effect of CNTNAP2 Polymorphisms on Cerebral Response to Human Voice Perception and Handedness: An fMRI Study International conference

    Koeda Michihiko, Watanabe Atsushi, Tsuda Kumiko, Matsumoto Miwako, Ikeda Yumiko, Kim Woochan, Tateno Amane, Than Naing Banyar, Karibe Hiroyuki, Shimada Takashi, Suzuki Hidenori, Matsuura Masato, Okubo Yoshiro

    The British Neuropsychiatry Association - 30th AGM  2017.2 

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  • Default mode network and Language-related resting state functional connectivity on handedness and family history International conference

    KOEDA Michihiko

    The 2nd meeting of International Conference on Brain Disorders and Therapeutics, 2016, Chicago  2016.10 

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    Language：English   Presentation type：Oral presentation (invited, special)  

    Venue：Chicago, USA  

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  • Comparison of frontal function during verbal fluency task by near-infrared spectroscopy and functional MRI International conference

    Michihiko Koeda, Moe Kidoguchi, Yuki Takahashi, Tomoko Hama, Tokuhiro Kawara, Yoshiro Okubo

    The 2nd meeting of International Conference on Brain Disorders and Therapeutics, 2016, Chicago  2016.10 

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    Language：English   Presentation type：Oral presentation (invited, special)  

    Venue：Chicago, USA  

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  • The infuence of language and default mode functional connectivity on handedness and family history International conference

    Michihiko Koeda, Yuki Takahashi, Moe Kidoguchi, Tokuhiro Kawara, Hiroyuki Karibe, Okubo Yoshiro

    The 22nd Organization for Human Brain Mapping 2016 Annual Meeting  2016.10 

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    Language：English   Presentation type：Poster presentation  

    Venue：Geneva, Switzerland  

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  • Interaction effect of voice-specific function and BDNF Val66Met: An fMRI study International conference

    Michihiko Koeda, Atsushi Watanabe, Yumiko Ikeda, Hiroyuki Karibe, Amane Tateno, Matsuura Masato, Hidenori Suzuki, Yoshiro Okubo

    The 23rd Organization for Human Brain Mapping 2017 Annual Meeting  2017.6 

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    Language：English   Presentation type：Poster presentation  

    Venue：Vancouver Convention Centre, Canada  

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  • 若年性統合失調症に対し、アリピプラゾール持続性注射剤が奏功した一例

    藤本 泰樹, 野上 毅, 肥田 道彦, 成重 竜一郎, 舘野 周, 大久保 善朗

    東京精神医学会学術集会  2017.3 

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    Language：Japanese   Presentation type：Oral presentation (general)  

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  • 音声認知時の脳機能と BDNF Val66Met の交互作用に関する fMRI 研究

    肥田道彦, 渡辺淳, 苅部洋行, 舘野周, 松浦雅人, 大久保善朗

    第20回日本ヒト脳機能マッピング学会  2017.3 

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  • 痛みの感情音聴取時の脳活動部位に関するfMRI研究

    冨澤大佑, 山崎陽子, 嶋田昌彦, 肥田道彦, 舘野周, 大久保善朗

    第46回慢性疼痛学会  2017.2 

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  • Effect of placebo and lorazepam on functional connectivity in fearful vocal processing: an fMRI study International conference

    KOEDA Michihiko

    The International College of Neuropsychopharmacology (CINP) World Congress  2016.6 

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  • 軽度認知機能障害患者の顔認知時の脳機能に関する予備的検討

    肥田道彦, 舘野 周, 大久保善朗

    第31回日本日本老年精神医学会  2016.6 

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    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：金沢歌劇座、金沢市、石川県  

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  • PHQ-9によるうつ病評価とNIRSによる前頭側頭機能評価の関連

    肥田道彦, 秋山友美, 下田健吾, 木村真人, 大久保善朗

    第112回日本精神神経学会総会学術総会  2016.6 

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    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：金沢歌劇座、金沢市、石川県  

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  • NIRSによる気分障害の病態研究～うつ状態の病態比較とm-ECT前後の前頭側頭機能比較～ Invited

    肥田道彦, 秋山友美, 下田健吾, 木村真人, 大久保善朗

    千葉総合病院精神科研究会  2016.4 

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    Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

    Venue：千葉市文化センター  

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  • 恐怖音声認知・脳処理時の機能的結合に対するプラセボ・ロラゼパムの効果：機能的MRI研究

    肥田 道彦

    第46回日本神経精神薬理学会年会  2016.7 

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  • アルツハイマー病と高齢者うつ病患者におけるseed-based解析を用いた安静時脳内ネットワークの比較に関する予備的検討

    濱 智子, 肥田道彦, 舘野 周, 川良 徳弘, 大久保善朗

    第20回日本ヒト脳機能マッピング学会  2017.10 

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  • ブプロピオンの情動認知時脳賦活に与える影響：予備的fMRI研究

    肥田道彦, 濱 智子, 池田裕美子, 舘野 周, 鈴木秀典, 大久保善朗

    第39回日本生物学的精神医学会・第47回日本神経精神薬理学会合同年会  2017.9 

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    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：札幌コンベンションセンター、北海道  

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  • 統合失調症の選択的音声感受領域の脳病態とFOXP2関連遺伝子の影響に関する検討:日本生物学的精神医学会若手研究者育成プログラム

    肥田 道彦

    第39回日本生物学的精神医学会・第47回日本神経精神薬理学会合同年会  2017.9 

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    Language：Japanese  

    Venue：札幌コンベンションセンター、北海道  

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  • Cerebral response to non-verbal painful vocalization: A preliminary fMRI study Invited International conference

    Michihiko Koeda, Daisuke Tomizawa, Tomoko Hama, Yuichi Kato, Hiroyuki Karibe, Amane Tateno, Yoshiro Okubo

    24th World Congress on Psychosomatic Medicine,  2017.9 

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    Language：English   Presentation type：Symposium, workshop panel (nominated)  

    Venue：China national convention center, Beijing, China  

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Awards

  • Best Poster Award

    2016.2   British Neuropsychiatory Association   Mazindol Effect on Cerebral Response to Nonverbal Affective Vocalization in Healthy Individuals: An fMRI Study

    KOEDA Michihiko

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  • Best Poster Award

    2015.8   International College of Psychosomatic Medicine   Cross-cultural Differences in the Processing of Fearful and Painful Vocalizations by Japanese and Canadian Listeners

    KOEDA Michihiko

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  • Award for Encouragement of Young Researcher

    2014.10   Japanese Society of Biological Psychiatry   Pathophysiology on Cerebral Processing of Selective Voice-specific Regions and its Influence by FOXP2-related gene in Schizophrenia

    KOEDA Michihiko

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  • Alwyn Lishman Prize

    2011.2   British Neuropsychiatry Association   Lorazepam and Placebo effect on cerebral processing of fearful vocalization: An fMRI study

    KOEDA Michihiko

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  • Award for Encouragement of Presentation at the International Congress

    2008.9   Japanese Society of Biological Psychiatry   Neural basis on Emotional Prosody in Schizophrenia: An fMRI Study

    KOEDA Michihiko

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  • Award for Encouragement of Research

    2007.9   Associate Professor and Lecturer Society, Nippon Medical School   Cerebral Laterality for Language Processing and Human Voice Perception, and its Pathophysiology in Schizophrenia

    KOEDA Michihiko

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  • Medical Research Institute Award

    2006.3   Medical Research Institute, Tokyo Medical and Dental University   Cerebral Processing of Language Processing and Human Voice Perception in Schizophrenia: An fMRI Study

    KOEDA Michihiko

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Research Projects

  • An attempt to elucidate the neurological basis of empathy and depression among medical professionals

    Grant number：23K09609  2023.4 - 2026.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    Eisho Yoshikawa, Michihiko Koeda, Amane Tateno, Nozumi Sukigara

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    Authorship：Coinvestigator(s) 

    Grant amount：\2990000 （ Direct Cost: \2300000 、 Indirect Cost：\690000 ）

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  • Development of treatment support program for dental phobia based on gaze measurement and brain activity analysis using VR technology

    Grant number：22K10299  2022.4 - 2026.3

    Hiroyuki Karibe, Michihiko Koeda, Satoshi Tanaka

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    Authorship：Coinvestigator(s) 

    Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）

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  • 薬理学的脳機能画像法と経頭蓋直流電気刺激法による痛みの共感に関する神経基盤の解明

    Grant number：19K07809  2019.4 - 2023.3

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    池田 裕美子, 舘野 周, 肥田 道彦

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    Authorship：Coinvestigator(s) 

    Grant amount：\4290000 （ Direct Cost: \3300000 、 Indirect Cost：\990000 ）

    共感は、重要な社会的認知機能の1つである。ヒトは、他者が喜びや悲しみといった情動および痛みのような感覚をどのように感じているかを理解することができる。近年、痛みの共感の障害が、神経障害性疼痛を始めとする様々な疾患で現れることが報告され、痛みの共感の神経基盤を解明する研究が活発に行われている。これまで痛みの共感に関する神経画像研究が行われているが、痛みの共感の神経基盤について一貫した見解は得られていない。本研究の目的は、薬理学的手法を使って、痛みの共感に関わる脳内ネットワークを特定することである。
    本年度は、薬理学的手法を用いた機能的磁気共鳴画像法(fMRI)によって特定された痛みの共感に関わる脳領域を検証するために、健常成人に経頭蓋直流電気刺激法(tDCS)を施行してfMRI検査を行い、取得したデータを使用して脳画像解析を行った。tDCSでは、シャム刺激を対照に処置を行い、電気刺激により下頭頂小葉を刺激した。fMRI検査では、被験者に他者が痛みを伴うような傷害を受けている画像と対照画像を呈示した。脳画像解析では、対照画像を見ている間の脳活動と比較して、他者が痛みを伴うような傷害を受けている画像を見ている間の脳活動が有意に増加している脳領域を、痛みの共感で活動する脳領域として評価した。その結果、痛みの共感では、島皮質を含む下前頭回、背内側前頭前野、下頭頂小葉の活動がみられた。現在、電気刺激による主観的な痛みの変化と上記の領域における脳活動変化を解析し、薬理学的手法によって特定された脳領域の検証を進めている。

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  • Clarification of the impairment of default mode/functional network due to tau-pathology pathway for Behavior problems of dementia

    Grant number：19K08028  2019.4 - 2022.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    Michihiko Koeda, Yoshiro Okubo, Amano Tateno

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    Authorship：Principal investigator 

    Grant amount：\4290000 （ Direct Cost: \3300000 、 Indirect Cost：\990000 ）

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  • Clarifying Brain Network on Dental Phobia by using non-invasive Neuroimaging and Development of its Coping Method

    2017.4 - 2021.3

    Nihon dental university  Grant-in-Aid for Scientific Research (C) 

    KOEDA Michihiko

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    Grant type：Competitive

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  • Development of Evaluation Methods of Affective Processing in Dementia Patients and Fusion Research between Default-Mode Neuroimaging and Molecular Neuroimaging

    2017.4 - 2020.3

    Nippon Medical School  Grants-in-Aid for Scientific Research (KAKENHI (Multi-year Fund)) - “Fund for the Promotion of Joint International Research (Fostering Joint International Research)” 

    KOEDA Michihiko

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    Authorship：Principal investigator  Grant type：Competitive

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  • Molecular Neuroimaging on Depression related to Amyloid plaque

    2015.4 - 2019.3

    Nippon Medical School  Grant-in-Aid for Scientific Research (B) 

    Yoshiro Okubo

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    Grant type：Competitive

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  • The Research of Molecular Neuroimaging related to Abnormality of Default-Mode Network in Dementia

    2015.4 - 2018.3

    Nippon Medical School  Grant-in-Aid for Scientific Research (C) 

    KOEDA Michihiko

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    Authorship：Principal investigator  Grant type：Competitive

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  • Quantitative Evaluation of Effective Cognitive-Behavioral Therapy for Dental Phobia by using non-invasive Neuroimaging

    2013.4 - 2017.3

    Nihon dental university  Grant-in-Aid for Scientific Research (C) 

    Hiroyuki Karibe

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    Grant type：Competitive

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  • Detection of Precursor Lesion of Alzheimer's Disease on Depression in Middle aged and Older Adults by Amyloid-molecular Neuroimaging

    2011.4 - 2015.3

    Nippon Medical School  Grant-in-Aid for Scientific Research (B) 

    Yoshiro Okubo

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    Grant type：Competitive

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  • Functional Neuroimaging and Genetic Research on Auditory Language Processing in Schizophrenia

    2007.4 - 2009.3

    Nippon Medical School  Grant-in-Aid for Young Scientists (B) 

    KOEDA Michihiko

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    Authorship：Principal investigator  Grant type：Competitive

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  • Molecular imaging of altered dopamine transmission in patients with schizophrenia

    Grant number：19390308  2007 - 2010

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    OKUBO Yoshiro, SAITO Takuya, TATENO Amane, ICHIMIYA Tetsuya, KOEDA Michihiko

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    Grant amount：\18330000 （ Direct Cost: \14100000 、 Indirect Cost：\4230000 ）

    Using positron emission tomography (PET) and different radioligands, we aimed to elucidate altered dopamine transmission in patients with schizophrenia. Using two different radioligands, [^<11>C]NNC112 and [^<11>C]SCH23390, we measured dopamine D1 receptor binding in patients with chronic schizophrenia and healthy controls. In patients with schizophrenia, the binding potentials of both ligands were significantly lower in the striatum and cortical regions than those of healthy controls. We measured presynaptic dopamine synthesis using PET with L-[β-^<11>C]DOPA and found that patients with schizophrenia showed higher dopamine synthesis in the left caudate nucleus, and that dopaminergic transmission in the thalamus and right temporal cortex might be implicated in the expression of symptoms in schizophrenia. Finally, we performed PET using [^<11>C]PE2I in patients with schizophrenia and healthy subjects to investigate dopamine transporter binding. Dopamine transporter binding in the thalamus of patients with schizophrenia was significantly higher than in control subjects. There were significant correlations between dopamine transporter binding and clinical symptom scores suggesting that altered dopamine transporter binding in the thalamus might be related to the pathophysiology and clinical symptoms of schizophrenia.

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  • An fMRI study in auditory task

    2000

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    Grant type：Competitive

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  • Reorganization of central nervous system

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    Grant type：Competitive

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Other research activities

  • Specialist

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    - Psychiatrist (acquired by the Japanese Society of Psychiatry and Neurology)
    - Designated Psychiatrist (acquired by Minister of Health, Labour and Welfare)
    - Geriatric Psychiatrist (acquired by the Japanese geriatric Psychiatry)
    - Specialist for Dementia (acquired by the Japanese society for Dementia)
    - Specialist for General Hospital Psychiatry (acquired by the Japanese society of GHP)

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Teaching Experience

  • 神経内科学

    Institution：文京学院大学

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  • 脳機能画像解析学

    Institution：東京医科歯科大学

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  • 医療統計学

    Institution：東京医科歯科大学

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  • Functional Neuroimaging and Analysis

    Institution：Tokyo Medical and Dental University

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  • Medical Statistics

    Institution：Tokyo Medical and Dental University

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  • 精神医学

    Institution：日本医科大学

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  • Clinical Psychiatry

    Institution：Nippon Medical School

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  • Neurology

    Institution：Bunkyo Gakuin University

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Social Activities

  • How to spend your climacteric period lively and in your own way: From a mental health perspective

    Role(s)： Lecturer

    Health Promotion Division, Tama City, Tokyo  Menopause course for women: Live your climacteric period in your own way  2024.3

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    Type：Lecture

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  • Progression and prevention of dementia: Towards the beginning of new treatment

    Role(s)： Lecturer

    Japanese society of Artificial Hearing Information, Chiba Prefecture Health Insurance Doctor Association  2024.2

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    Type：Lecture

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  • ~Dementia Q&A~ Would you like to think about the problem of forgetfulness together?

    Role(s)： Panelist,　Lecturer

    Shikaoi city, Kato-Gun, Shikaoi City  FY2023 Dementia/Adult Guardian Seminar  2024.1

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    Type：Lecture

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  • Special talk event: Mini-seminar to think about hearing from the brain: “Hearing loss and dementia” special talk; Recommendation of Cognisize

    Role(s)： Appearance,　Panelist,　Commentator,　Lecturer,　Advisor,　Informant

    Demant Japan Co., Ltd. 50th Anniversary Event Secretariat  Demanto Japan 50th Anniversary Event “Hearing Technology that Changes Lives”  2023.9

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    Type：Seminar, workshop

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  • Recognition of sounds & words and dementia -How does dementia progress? ~

    Role(s)： Appearance,　Panelist,　Lecturer

    The Japanese society of Artificial Auditory Information Society  deafness expo 2023  2023.4

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    Type：Lecture

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  • It’s a worry. A disease of "cognition": cutting-edge of forgetfulness; clinical care of dementia

    Role(s)： Appearance,　Panelist,　Lecturer

    Shikaoi city, Kato-Gun, Shikaoi City  townspeople lecture  2022.12

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    Type：Lecture

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  • It’s a worry. A disease of "cognition": cutting-edge of research and clinical care of dementia

    Role(s)： Appearance,　Panelist,　Lecturer

    Women's Organizations Liaison Committee in Bunkyo-Ku, Tokyo, Japan  Gender Equality Center Project in Bunkyo-Ku, Tokyo: plus One Seminar  2022.7

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    Type：Lecture

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Media Coverage