Updated on 2024/03/24

写真a

 
Go Ichikawa
 
Affiliation
Chibahokusoh Hospital, Department of Obstetrics and Gynecology, Senior Assistant Professor
Title
Senior Assistant Professor
External link

Degree

  • 医学博士 ( 日本大学大学院医学研究科外科系産婦人科学 )

Research Interests

  • endometriosis

  • Reproductive Immunology

  • 早産

  • 不育症

  • obstetrics and gynecology

  • 母体救命

Research Areas

  • Life Science / Immunology

  • Life Science / Embryonic medicine and pediatrics  / 胎児超音波

  • Life Science / Obstetrics and gynecology

Education

  • Nihon University   Graduate School, Division of Medicine   reproductive immunology

    2005.4 - 2009.3

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  • Nihon University   School of Medicine

    1996.4 - 2002.3

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  • Gyosei high school

    1990.4 - 1993.3

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Research History

  • Nippon Medical School Chiba Hokuso Hospital   Division of Obstetrics and Gynecology

    2022.4

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    Country：Japan

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  • NIPPON MEDICAL SCHOOL MUSASHIKOSUGI HOSPITAL   Division of Obstetrics and Gynecology   Assistant Professor   Assistant Professor

    2020.10 - 2022.3

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    Country：Japan

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  • Kawaguchi Municipal Medical Center   obstetrics and gynecology

    2018.4 - 2020.9

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  • Yale University   Department of Obstetrics Gynecology & Reproductive Sciences   Guest assistant professor

    2015.1 - 2015.10

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  • Nihon University School of Medicine, Department of Medicine   Assistant Professor

    2009.4 - 2018.3

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Professional Memberships

  • Japan Society of Clinical Genetics in Obstetrics and Gynecology (JSGOG)

    2021.4

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  • International Society for immunology of reproduction

    2015.4

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  • 日本癌治療学会

    2011.4

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  • 日本胎盤学会

    2007.4

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  • The American Society for Reproductive Immunology

    2007.4

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  • 日本妊娠高血圧学会

    2007.4

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  • 日本産婦人科内視鏡学会

    2006.7

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  • 日本周産期新生児学会

    2003.4

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  • Japan Society of Obstetrics and Gynecoligy

    2002.4

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Papers

  • Kikuchi–Fujimoto disease during early pregnancy

    Go Ichikawa, Yasuyuki Negishi, Fumihisa Chishima, Shunji Suzuki

    Journal of Obstetrics and Gynaecology Research   2024.3

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    Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    Abstract

    Kikuchi–Fujimoto disease (KFD) is rare during pregnancy. It is characterized by necrotizing lymphadenitis and often occurs in young Asian women. We report a case of KFD during pregnancy, which was difficult to diagnose. A 37‐year‐old pregnant female (gestational week [GW] 7+5) was admitted to our hospital because of hyperemesis gravidarum. On the eighth day of hospitalization (GW 8+6), she suddenly developed a fever (38.0°C) with skin rash and posterior pharynx redness. Blood tests showed pancytopenia and abnormal liver function. The patient was misdiagnosed with severe Epstein–Barr virus infection and administered with prednisolone. Subsequently, cervical lymphadenopathy was observed, and biopsy results led to the diagnosis of KFD. Thereafter, her symptoms improved, and she was discharged at GW 13+4. KFD must be included as a differential diagnosis for patients with fever, abnormal liver function, and pancytopenia during pregnancy.

    DOI： 10.1111/jog.15928

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  • 低用量エストロゲン・プロゲスチン配合剤投与で疼痛を制御できたAccessory cavitated uterine mass(ACUM)を強く疑う1例

    施 紅蓮, 松島 隆, 滝澤 彩子, 長島 麻子, 針金 永佳, 渡邉 朝子, 角田 陽平, 新村 裕樹, 倉品 隆平, 市川 剛, 鈴木 俊治

    日本エンドメトリオーシス学会会誌   44   65 - 68   2023.9

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    Language：Japanese   Publisher：日本エンドメトリオーシス学会  

    Accessory cavitated uterine mass(ACUM)はまれな子宮嚢胞性疾患で,30歳未満の若年女性に好発し,重症の月経困難症や慢性的な下腹部痛を症状とする.ACUMの多くは,ホルモン療法に抵抗するといわれている.今回,低用量エストロゲン・プロゲスチン配合剤(LEP)投与により疼痛が軽快し保存療法を継続できているACUMを強く疑う1症例を経験したので報告する.症例は23歳,未妊の女性で,1年前から月経痛と持続下腹部痛を認め,経腟超音波断層像では子宮は正常大を示し,子宮左側壁に内腔を有する約3cm大の腫瘤を認めた.骨盤部MRIでは子宮筋腫や子宮腺筋症は検出されず,左子宮円索起始部付近にT1強調画像で高信号,T2強調画像でshadingを示す内腔を有する嚢胞を認めACUMを強く疑った.治療方針として手術を提案したが希望されず,保存的治療としてLEPを投与した.投与開始2ヵ月後には,疼痛は減少した.ACUMが疑われるが手術を希望されない症例にLEP投与が有効となりうると考えられた.(著者抄録)

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  • Evaluating the effectiveness of lateral postural management for breech presentation: study protocol for a randomized controlled trial (BRLT study). International journal

    Hiroki Shinmura, Takashi Matsushima, Asako Watanabe, Honglian Shi, Asako Nagashima, Ayako Takizawa, Mayu Yamada, Eika Harigane, Youhei Tsunoda, Ryuhei Kurashina, Go Ichikawa, Shunji Suzuki

    Trials   24 ( 1 )   360 - 360   2023.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: Breech presentation is observed in 3-4% at term of pregnancy and is one of the leading causes of cesarean section. There is no established treatment for breech presentation before 36 weeks. A retrospective cohort study was conducted to demonstrate that the lateral position is effective for breech presentation. However, there are no randomized controlled trials evaluating lateral position management for breech presentation. Here, we described the methodology of a randomized controlled trial of a cephalic version for breech presentation in the third trimester by lateral postural management (BRLT study). METHODS: The BRLT study is an open-label, randomized controlled trial with two parallel groups allocated in a 1:1 ratio to examine the lateral position management for breech presentation, as compared with expectant management care. An academic hospital in Japan will enroll 200 patients diagnosed with a breech presentation by ultrasonography between 28 + 0 weeks and 30 + 0 weeks. Participants in the intervention group will be instructed to lie on their right sides for 15 min three times per day if the fetal back was on the left side or lie on their left sides if the fetal back was on the right side. The instruction will be given every 2 weeks after confirmation of fetal position, and the lateral position will be instructed until the cephalic version, and after the cephalic version, the reverse lateral position will be instructed until delivery. The primary outcome is cephalic presentation at term. The secondary outcomes are cesarean delivery, cephalic presentation 2, 4, and 6 weeks after the instruction, and at delivery, recurrent breech presentation after cephalic version, and adverse effects. DISCUSSION: This trial will answer whether the lateral positioning technique is effective in treating breech presentation and, depending on the results, may provide a very simple, less painful, and safe option for treating breech presentation before 36 weeks, and it may impact breech presentation treatment. TRIAL REGISTRATION: UMIN Clinical Trials Registry UMIN000043613. Registered on 15 March 2021 https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000049800 .

    DOI： 10.1186/s13063-023-07395-w

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  • Pseudo Meigs症候群を呈した卵巣甲状腺腫の一例

    松原 怜, 白井 有香, 市川 直樹, 田中 孝和, 吉川 千晶, 門屋 悠里, 尾市 有里, 深川 知明, 中西 一歩, 可世木 華子, 市川 剛, 鈴木 俊治

    関東連合産科婦人科学会誌   59 ( 3 )   311 - 311   2022.10

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    Language：Japanese   Publisher：(一社)関東連合産科婦人科学会  

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  • OHSSに脳梗塞を合併した1例

    名川 歩美, 倉品 隆平, 施 紅蓮, 滝澤 彩子, 山田 舞夕, 針金 永佳, 渡邉 朝子, 角田 陽平, 新村 裕樹, 市川 剛, 松島 隆, 鈴木 俊治

    神奈川産科婦人科学会誌   59 ( 1 )   89 - 89   2022.9

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    Language：Japanese   Publisher：神奈川産科婦人科学会  

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  • Allergy testing for Cremophor in a patient with cervical cancer with infusion reactions to paclitaxel and docetaxel. International journal

    Kazuho Nakanishi, Shizuka Okazaki, Go Ichikawa, Shunji Suzuki

    BMJ case reports   15 ( 6 )   2022.6

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    Language：English   Publishing type：Research paper (scientific journal)  

    A woman in her 30s with cervical cancer underwent postoperative chemotherapy and showed allergic reactions to multiple taxanes. As the patient had infusion reactions to both paclitaxel and docetaxel, a prick test with Cremophor was conducted. In the absence of an allergic reaction to etoposide, we determined that the patient was allergic to pure taxane compounds. Among infusion reactions caused by taxanes, Cremophor allergy is reported in 3% of cases. Therefore, a prick test with Cremophor performed on a taxane infusion reaction will be useful in diagnosing allergy. In addition, allergy due to docetaxel may be managed by adequate premedication and continuous intravenous chlorpheniramine administration.

    DOI： 10.1136/bcr-2022-250960

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  • 当院で入院管理した卵巣過剰刺激症候群21症例の検討

    施 紅蓮, 倉品 隆平, 市川 剛, 新村 裕樹, 滝澤 彩子, 角田 陽平, 長島 麻子, 針金 永佳, 松島 隆, 山田 舞夕, 渡邉 朝子, 鈴木 俊治

    関東連合産科婦人科学会誌   59 ( 2 )   218 - 218   2022.5

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    Language：Japanese   Publisher：(一社)関東連合産科婦人科学会  

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  • 後期早産期の前置胎盤合併妊婦から出生した新生児の呼吸適応への影響

    角田 陽平, 施 紅蓮, 滝澤 彩子, 長島 麻子, 山田 舞夕, 針金 永佳, 渡邉 朝子, 新村 裕樹, 倉品 隆平, 市川 剛, 松島 隆, 鈴木 俊治

    日本産科婦人科学会雑誌   74 ( 臨増 )   S - 393   2022.2

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    Language：Japanese   Publisher：(公社)日本産科婦人科学会  

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  • Cephalic version by postural management in the lateral position without the knee-chest position for primiparous breech presentation: A retrospective cohort study. International journal

    Hiroki Shinmura, Takashi Matsushima, Naofumi Okuda, Asako Watanabe, Asako Nagashima, Mayu Yamada, Eika Harigane, Youhei Tsunoda, Go Ichikawa, Shunji Suzuki

    The journal of obstetrics and gynaecology research   48 ( 3 )   703 - 708   2022.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    AIM: This study aimed to determine the efficacy of postural management in the lateral position for primiparous breech presentation. METHODS: A retrospective cohort study was conducted at a single institution from January 2020 through December 2020. Participants were singleton primiparous pregnant women diagnosed with breech presentation between 28 + 0 and 29 + 6 weeks of gestation. The exclusion criteria were scheduled cesarean delivery, uterine malformation, transverse position, and scheduled delivery at another hospital. A doctor instructed the women in the intervention group to lie on their right sides several times a day if the fetal back was on the left side or lie on their left sides if the fetal back was on the right side. The knee-chest position and other methods were not recommended. The control group received expectant management care. The primary endpoint was the percentage of fetuses in a cephalic presentation 2 weeks later. RESULTS: Of the 56 women included in the study, 17 women were instructed to lie in the lateral position, and 39 women received expectant management care only. After 2 weeks, women who were instructed to lie in lateral position had a higher rate of fetal cephalic version than the control group (82.4% [14/17] vs. 43.6% [17/39], p = 0.017). No study participants experienced adverse effects. CONCLUSIONS: Two weeks of postural management in the lateral position without the knee-chest position significantly reduced the rate of primiparous breech presentation in the third trimester of pregnancy.

    DOI： 10.1111/jog.15149

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  • Zinc deficiency is associated with gynecologic cancer recurrence. International journal

    Kazuho Nakanishi, Masafumi Toyoshima, Go Ichikawa, Shunji Suzuki

    Frontiers in oncology   12   1025060 - 1025060   2022

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    Language：English   Publishing type：Research paper (scientific journal)  

    Zinc deficiency can cause various symptoms, including hair loss, anemia, and taste disorders. Recently, the association between cancer and zinc deficiency has received much attention with respect to its antioxidant properties. However, only a few studies have investigated the association between gynecologic cancers and zinc; to date, no studies have evaluated serum zinc status at the onset of gynecologic cancer or the relationship between zinc and cancer recurrence. The objectives of the present study were to determine whether serum zinc concentrations are associated with the development of gynecologic cancer, to clarify serum zinc dynamics between the onset and recurrence of gynecologic cancer, and to identify the associated factors. Accordingly, we retrospectively determined serum zinc concentrations before treatment in gynecologic patients with benign disease or cancer at the Nippon Medical School Chiba Hokusoh Hospital. We investigated anemia and hypoalbuminemia-the most common causes of zinc deficiency-as indicators of hyponutrition to determine the causal relationship of this deficiency with chemotherapy, radiation therapy, and recurrence, which may affect zinc concentration during cancer recurrence. The results indicated that there was no difference in zinc concentration between preoperative cancer patients and noncancer patients and that serum zinc concentrations were not associated with developing gynecologic cancers. However, patients with gynecologic cancer exhibited significantly lower serum zinc concentrations following treatment, and patients with recurrent cancer were 4.8 times more likely to develop zinc deficiency than those with nonrecurrent cancer. A serum zinc concentration of <61 μg/dL was an independent predictor of recurrence. Once zinc deficiency occurred, the recurrence rate of zinc deficiency reached as high as 69%. Overall, our study indicates that zinc deficiency is associated with recurrence in gynecological cancers and physicians should monitor zinc levels during disease management.

    DOI： 10.3389/fonc.2022.1025060

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  • Retained products of conceptionに対し総腸骨動脈バルーン閉塞術と子宮脈塞栓術を併用し子宮鏡下に摘出し治療しえた1例

    滝澤 彩子, 松島 隆, 施 紅蓮, 長島 麻子, 山田 舞夕, 針金 永佳, 渡邉 朝子, 角田 陽平, 新村 裕樹, 倉品 隆平, 市川 剛, 明楽 重夫, 鈴木 俊治

    日本産科婦人科内視鏡学会雑誌   37 ( Suppl.I )   360 - 360   2021.9

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    Language：Japanese   Publisher：(一社)日本産科婦人科内視鏡学会  

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  • 骨盤高位ポジショニングパッドの導入

    市川 剛, 施 紅蓮, 滝澤 彩子, 長島 麻子, 山田 舞夕, 針金 永佳, 渡邉 朝子, 角田 陽平, 新村 裕樹, 倉品 隆平, 可世木 華子, 市川 雅男, 松島 隆, 明樂 重夫, 鈴木 俊治

    日本産科婦人科内視鏡学会雑誌   37 ( Suppl.I )   384 - 384   2021.9

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    Language：Japanese   Publisher：(一社)日本産科婦人科内視鏡学会  

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  • 腸管子宮内膜症による腸管狭窄で腸閉塞を繰り返し、腹腔鏡下S状結腸切除を施行し改善した1例

    角田 陽平, 市川 剛, 横山 康行, 施 江蓮, 滝澤 彩子, 長島 麻子, 山田 舞夕, 針金 永佳, 渡邉 朝子, 新村 裕樹, 可世木 華子, 倉品 隆平, 市川 雅夫, 松島 隆, 明樂 重夫, 鈴木 俊治

    日本産科婦人科内視鏡学会雑誌   37 ( Suppl.I )   286 - 286   2021.9

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  • 子宮鏡下胎嚢切除術を施行した子宮峡部妊娠の2症例

    菅原 望央, 稲垣 知子, 奥田 直史, 長島 麻子, 山田 舞夕, 針金 永佳, 角田 陽平, 渡邉 朝子, 新村 裕樹, 加藤 雅彦, 市川 剛, 深見 武彦, 松島 隆

    神奈川産科婦人科学会誌   58 ( 1 )   117 - 117   2021.9

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    Language：Japanese   Publisher：神奈川産科婦人科学会  

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  • 子宮鏡下胎嚢切除術を施行した子宮峡部妊娠の2症例

    菅原 望央, 稲垣 知子, 奥田 直史, 長島 麻子, 山田 舞夕, 針金 永佳, 角田 陽平, 渡邉 朝子, 新村 裕樹, 加藤 雅彦, 市川 剛, 深見 武彦, 松島 隆

    神奈川医学会雑誌   48 ( 2 )   49 - 50   2021.7

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    Language：Japanese   Publisher：神奈川県医師会  

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  • 心臓、肝臓、胆嚢を共有している胸腹部結合双胎の1例

    橋本 恵里那, 市川 剛, 河野 愛, 中山 琢生, 仲尾 岳大, 東 裕福, 林 忠佑, 小松 篤史, 千島 史尚, 高田 眞一, 宮川 康司, 川名 敬

    東京産科婦人科学会会誌   67 ( 3 )   520 - 524   2018.7

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    Language：Japanese   Publisher：(一社)東京産科婦人科学会  

    結合双胎は非常に稀な疾患であり超音波断層法検査の進歩によって早期診断が可能となってきたが、共有臓器が多い場合などは現在も診断は容易ではなく見落とされる可能性もある。今回妊娠17週に胸腹部結合双胎と診断された症例を経験したので報告する。症例:36歳、2妊0産(自然流産1回)。夫はEDに対してPDE5阻害薬(バイアグラ)を内服しておりカンボジア滞在が長期にわたっていた。クロミフェンクエン酸塩+人工授精(AIH)で妊娠し、妊娠14週までは異常を指摘されなかったが、妊娠17週で脊椎が2本確認され心臓を共有する胸腹部結合双胎が疑われた。患者・家族と相談し人工妊娠中絶を行う方針となり妊娠19週に経腟分娩で死産となった。児は胸壁から臍上部までの結合と臍帯ヘルニアを認めた。結論:超音波断層法検査で胎児を観察する場合には、妊娠初期であっても長軸方向だけでなく短軸方向も確認する必要がある。(著者抄録)

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  • クローン病合併妊娠の経腟分娩後に長期間持続する外陰部膿瘍を伴った潜在的な直腸腟瘻の1例

    長谷川 怜美, 新屋 芳里, 大熊 勇気, 橋本 恵里那, 小林 理, 仲尾 岳大, 春日 晃子, 林 忠佑, 東 裕福, 市川 剛, 小松 篤史, 千島 史尚, 高田 眞一, 川名 敬

    東京産科婦人科学会会誌   67 ( 1 )   36 - 41   2018.1

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    Language：Japanese   Publisher：(一社)東京産科婦人科学会  

    直腸腟瘻は分娩外傷やクローン病、放射線治療が原因となって起こることが知られている。我々はクローン病合併患者で分娩後に外陰部膿瘍に進行した潜在的な直腸腟瘻の症例を経験した。症例:31歳女性。前医の総合周産期センターで正常経腟分娩にて第1子を出産した。3時と6時方向に第2度会陰裂傷を認め、会陰縫合施行後、経過良好で退院した。退院後発熱と下痢を認め、産後にクローン病と診断された。その後「腟からガスが出る」との自覚症状が出現。外陰部膿瘍を認め徐々に増大。2年症状が持続し当科初診。手術にて、腟口部直下からの瘻孔を認め、瘻孔と膿瘍腔の交通を確認した。外陰部膿瘍除去術・瘻孔閉鎖術を施行した。術後、自覚症状は速やかに消失し、膿瘍の再発なく経過している。結論:クローン病合併妊婦では、経腟分娩後の直腸腟瘻のリスクが高い。外陰部膿瘍は潜在的な直腸腟瘻の存在を知る手がかりとなると考えられた。(著者抄録)

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  • The Expression of MAS1, an Angiotensin (1-7) Receptor, in the Eutopic Proliferative Endometria of Endometriosis Patients. International journal

    Takahiro Nakajima, Fumihisa Chishima, Takehiro Nakao, Chuyu Hayashi, Akiko Kasuga, Kaori Shinya, Takuo Nakayama, Hiromitsu Azuma, Go Ichikawa, Atsushi Komatsu, Tatsuo Yamamoto, Kei Kawana

    Gynecologic and obstetric investigation   83 ( 6 )   600 - 607   2018

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    BACKGROUND/AIM: We demonstrated that AT1 and AT2 are expressed and both pathways balance the renin-angiotensin system in endometriosis. MAS1, a specific receptor of angiotensin (1-7), opposes AT1 pathway-associated tissue remodelling. It is not known whether MAS1 has an effect on the pathogenesis of endometriosis or not. MATERIALS AND METHODS: Ovarian endometriotic tissues (endo-Ov) and eutopic endometrial tissues (endo-Em) were obtained from 29 patients with endometrial cysts. Normal endometrial tissues (cont-Em) were obtained from patients without endometriosis. Immunohistochemical staining was performed for MAS1, AT1 and AT2 in the endometriosis-associated tissues. The mRNA levels of these receptors were examined by quantitative reverse transcription PCR. RESULTS: MAS1 was immune-positive at the apical side of the glandular epithelium in the endometriotic lesions. The MAS1 mRNA levels in endo-Ov were increased significantly, irrespective of the menstrual cycle phase. The MAS1 mRNA levels were significantly higher in the proliferative-tissues of the endometriosis patients than in those of the controls. The ratio of the MAS1 to the AT1 mRNA in the proliferative tissues was increased predominantly in the endometriosis patients compared with that in the controls. CONCLUSION: High MAS1 expression in the endometrium might promote the initiation of endometriosis via migration of proliferative tissue.

    DOI： 10.1159/000490561

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  • 妊娠中後期の経腟color Doppler法が有用だった前置血管の1例

    庄司 果野子, 市川 剛, 河野 愛, 松野 孝幸, 中山 琢生, 加藤 恵利奈, 東 裕福, 林 忠佑, 宮川 泰司, 小松 篤史, 高田 眞一, 千島 史尚, 川名 敬

    東京産科婦人科学会会誌   66 ( 4 )   673 - 676   2017.10

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    前置血管は断裂した場合、胎児死亡率が75～100%に至る疾患で、最も安全で最適な娩出法はエビデンスや管理法が確立されていない。今回、出生前診断により適切に入院管理し、合併症なく娩出し得た前置血管の症例を経験した。37歳の1回経産婦が妊娠31週に前置血管を疑われ、当院を紹介受診した。経腟超音波検査で内子宮口近傍に卵膜に付着するように走行する管状構造を認め、color Doppler法を併用し、前置血管と診断した。同日より血管の破綻のリスクを回避するため入院管理とした。妊娠36週に選択的帝王切開し健児を得た。経腟超音波検査のcolor Doppler法は出生前診断に有用である。妊婦健診で頸管長を観察する際には前置血管も念頭に診察すべきである。(著者抄録)

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  • Successful pregnancy in a case of bladder and ovary endometriosis following cystoscopy-assisted laparoscopic resection Reviewed

    Fumihisa Chishima, Go Ichikawa, Katsuhiko Sato, Toshiyuki Ishige, Masahiko Sugitani, Tatsuo Yamamoto

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   40 ( 6 )   1803 - 1806   2014.6

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    A 34-year-old, gravida 0 para 0 Japanese woman visited a regional hospital complaining of dysmenorrhea, hematuria during menstruation, and right inguinal pain. She had a history of dysmenorrhea and three prior rounds of in vitro fertilization with embryo transfer, which were all with transfers of cryopreserved-thawed single embryos in natural cycles, resulting in no pregnancy. An ultrasound revealed a large 2x1-cm nodule between the bladder and the anterior wall of the uterus and a 3-cm cystic lesion in the right adnexal area. A combined cystoscopic and laparoscopic resection of the bladder endometriosis and cystectomy of the right endometrioma were carried out. A single ultrasound-guided transfer of a cryopreserved-thawed embryo in the cleavage stage was performed 4 months postoperatively, which resulted in an uncomplicated pregnancy. The combined, single procedure was minimally invasive and eradicated the lesions that may have caused the infertility.

    DOI： 10.1111/jog.12397

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  • 血流豊富な胎盤ポリープに対する内腸骨動脈バルーン閉鎖を用い妊孕性を重視した治療戦略

    市川 剛, 千島 史尚, 松野 孝幸, 高橋 英幹, 高田 眞一, 山本 樹生, 前林 俊也

    日本産科婦人科内視鏡学会雑誌   29 ( Suppl.I )   123 - 123   2013.8

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  • Rare case of primary peritoneal pregnancy infiltrated into the Gerota's fascia of the right kidney Reviewed International journal

    Fumihisa Chishima, Erina Kato-Suzuki, Go Ichikawa, Chuyu Hayashi, Sumie Ohni, Tatsuo Yamamoto

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   39 ( 5 )   1073 - 1076   2013.5

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    A 33-year-old, gravida 3, para 2, woman was transferred to our hospital, with acute abdominal pain. Abdominal computed tomography (CT) revealed a cystic lesion accompanied by ring-enhancement between the liver and right kidney with fluid collection in the pelvic cavity. Serum hCG value was 3100mIU/mL. Transvaginal sonography revealed a pseudo-gestational sac in a thickened endometrium. With a preoperative diagnosis of ectopic pregnancy at 7 weeks of gestation, laparotomy was performed. Following careful removal of clots between the liver and right kidney that contained a gestational sac, continuous bleeding from a defect in the Gerota's fascia of the right kidney was noted. The postoperative course was uneventful and the serum hCG concentration decreased markedly. This case demonstrates that the Gerota's fascia is a possible site of ectopic pregnancy, and that CT can identify a pregnancy in the Gerota's fascia as well as in the liver and spleen.

    DOI： 10.1111/j.1447-0756.2012.02057.x

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  • Relationship Between Toll-like Receptor-4 and mPGES-1 Gene Expression in Local Lesions of Endometriosis Patients Reviewed International journal

    Chuyu Hayashi, Fumihisa Chishima, Masahiko Sugitani, Go Ichikawa, Teine Nakazawa-Watanabe, Kenji Sugita, Manami Suzuki, Norimichi Nemoto, Tatsuo Yamamoto

    AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY   69 ( 3 )   231 - 239   2013.3

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    Problem Toll-like receptors (TLRs) are innate immune receptors that mediate the pattern recognition of, and response toward, pathogens and host-derived danger signals. We reported that cyclooxygenase-2 (COX-2) and microsomal prostaglandin E synthase (mPGES) mRNA were expressed in cases of endometriosis. The relationship between COX-2, mPGES-1, and TLR4 in endometriotic lesions has yet to be determined. Method of study Endometriosis samples were obtained from 37 patients with endometrial cysts. Endometrial tissues were obtained from patients undergoing surgical procedures for benign gynecological conditions. COX-2, mPGES-1, and TLR4 mRNA expressions were examined by real-time quantitative reverse transcription PCR (qRT-PCR) and mPGES-1, and TLR4 protein localization was examined by immunohistochemistry. Results TLR4 proteins were mostly located to the glandular epithelium. The immunoreactivities of TLR4 and mPGES-1 from endometriosis lesions were significantly higher than those in eutopic endometrium in the proliferative phase. The expression levels of mPGES-1 mRNA in peritoneal endometriosis were higher than those in eutopic endometrium in the proliferative phase. The expression of TLR4 mRNA correlates with that of mPGES-1 mRNA and not with that of COX-2 in endometriotic lesions. Conclusion Relationship between TLR4 and mPGES-1 mRNA in endometriotic lesions indicate that innate immunity may play an important role in the pathogenesis of endometriosis.

    DOI： 10.1111/aji.12056

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  • Effects of anti-beta 2-glycoprotein I antibody on PlGF, VEGF and sVEGFR1 production from cultured choriocarcinoma cell line Reviewed International journal

    Go Ichikawa, Tatsuo Yamamoto, Fumihisa Chishima, Akikazu Nakamura, Souichirou Kuno, Takayuki Murase, Manami Suzuki

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   37 ( 8 )   1076 - 1083   2011.8

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：WILEY-BLACKWELL  

    Aim: Anti-beta 2-glycoprotein I (Anti-beta 2-GPI) antibody has been detected in cases of recurrent abortion and intrauterine death. Placenta growth factor (PlGF) and vascular endothelial growth factor (VEGF) are growth factors that accelerate villous proliferation. Soluble VEGF receptor-1 (sVEGFR1) is a soluble receptor for PlGF and suppresses the function of PlGF. In order to study the pathological mechanism of Anti-beta 2-GPI antibody, we evaluated the effects of Anti-beta 2-GPI antibody on PlGF, VEGF and sVEGFR1 production from cultured choriocarcinoma cells.
    Methods: The sera were taken from six Anti-beta 2-GPI antibody-positive and six Anti-beta 2-GPI antibody-negative patients with recurrent miscarriages. Choriocarcinoma cells (JEG-3) were cultured in 24-well plates. After each serum and isolated immunoglobulin G (IgG) were added to the culture medium, the PlGF, VEGF and sVEGFR1 in the culture medium were measured by ELISA 24 h later. When the isolated IgG was added to culture medium, only the levels of PlGF were measured.
    Results: The Anti-beta 2-GPI antibody-positive sera and isolated IgG significantly suppressed the production of PlGF from JEG-3 cells more strongly than the Anti-beta 2-GPI antibody-negative sera. The suppressive effects were not changed by serum inactivation. There was no significant difference in the values of the XTT assay and the production of VEGF and sVEGFR1 between the antibody-positive and antibody-negative sera.
    Conclusions: Anti-beta 2-GPI antibody-positive sera and IgG suppress the production of PlGF from JEG-3 cells. We suggest that the Anti-beta 2-GPI antibodies may suppress PlGF production from trophoblasts and cause the failure of placenta formation and function.

    DOI： 10.1111/j.1447-0756.2010.01490.x

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  • Placental trophoblast damage by anti-β2-glycoprotein 1 antibody

    Clinical immunology & allergology   52 ( 2 )   188 - 193   2009.8

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  • 抗β2グリコプロテインI抗体による絨毛障害

    市川 剛, 山本樹生

    臨床免疫・アレルギー科   52 ( 2 )   188-189   2009.2

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  • Leukocyte subpopulation in ascites of women with pre-eclampsia. Reviewed International journal

    Tatsuo Yamamoto, Takayuki Murase, Souichiro Kuno, Go Ichikawa, Fumihisa Chisima

    American journal of reproductive immunology (New York, N.Y. : 1989)   60 ( 4 )   318 - 24   2008.10

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    Problem
    Pre-eclampsia is associated with excessive maternal systemic inflammatory response. The immune cells in ascites of pre-eclampsia have not been studied well. In order to investigate the inflammatory response in ascites of pre-eclampsia, we studied leukocytes subpopulation in ascites.
    Method of study
    Maternal peripheral blood samples and ascites were taken from 10 cases of pre-eclampsia. Antibody-labeled cells were analyzed by flow cytometry.
    Results
    The leukocytes subpopulation in ascites taken from pre-eclampsia was different from that in the peripheral blood. The largest population of leukocytes in ascites was CD14+ monocyte/macrophage. The percentages of macrophage, CD56+ cells, CD56 + 16-3- NK cell (immunoregulatory NK cell), and CD56 + 3+ T cell (CD56+ T cell including NK T cell) increased in ascites compared with those in the peripheral blood. The median percentages of CD56 + 16-3- NK cells were 22.2%. The half of the CD3+ T cells originated from the increased CD56 + 3+ T cells.
    Conclusion
    We demonstrated the accumulation of the macrophage and the CD56+ cells into the ascites taken from pre-eclampsia patients. This finding may relate to excessive inflammatory response in pre-eclampsia.

    DOI： 10.1111/j.1600-0897.2008.00629.x

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  • [A case of brain metastasis from advanced ovarian clear-cell carcinoma during maintenance chemotherapy with irinotecan+cisplatin].

    Masashi Takami, Eisuke Kita, Yoshikazu Kuwana, Yoshiaki Ohta, Yasuo Nakayama, Hiroshi Fukai, Hiroshi Matsumoto, Toshirou Takimoto, Go Ichikawa, Tatsuo Yamamoto

    Gan to kagaku ryoho. Cancer & chemotherapy   35 ( 7 )   1243 - 5   2008.7

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    Clear-cell carcinoma of the ovary is a highly malignant neoplasm. Survival of patients in the advanced stage is poor, and the best treatment is not clear. We report here a case of a 57-year-old woman who had Stage IIIb advanced clearcell carcinoma of the ovary. We performed abdominal hysterectomy, bilateral salpingo-oophorectomy, pelvic lympho adenectomy and partial omentectomy. After the operation she was placed on induction and maintenance chemotherapy with a combination of irinotecan(CPT-11)(60 mg/m2, day 1, 15)plus cisplatin(CDDP)(60 mg/m2, day 1). Four years after surgery, a metastatic tumor was found in the brain. Considering the poor prognosis of clear-cell carcinoma, this regimen is thought to be effective for advanced clear-cell carcinoma of the ovary. It is important to check brain metastases under maintenance chemotherapy.

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  • 妊娠時の免疫系 (周産期臨床検査のポイント) -- (産科編 基本的な検査)

    山本 樹生, 松浦 眞彦, 市川 剛

    周産期医学   38   48 - 53   2008

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    Other Link： http://search.jamas.or.jp/link/ui/2009071364

  • 体外受精症例における卵管性不妊の取り扱い 特に卵管留症に対する卵管開口術、卵管クリッピングの効果について

    長田 尚夫, 柿沼 敏行, 市川 剛, 山本 範子, 山本 樹生, 加藤 恵一, 井上 正樹, 瀬川 智也, 奥野 隆, 貝嶋 弘恒, 寺元 章吉, 加藤 修, 越智 正憲, 川村 寿宏, 辰巳 賢一

    日本産科婦人科内視鏡学会雑誌   23 ( 1 )   59 - 66   2007.12

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    卵管留症の頻度・病態、診断、治療法、手術成績、予後因子からみた治療法選択について述べた後、体外受精による胚移植(IVF-ET)症例の卵管留症に対する治療成績を報告した。内訳はIVF-ETの際に卵管留症を認め、卵管内貯留液を吸引してから胚移植を行った52例(A群)と、吸引法で妊娠が成立せず、腹腔鏡下手術により卵管開口術後に子宮と卵管の交通を遮断(卵管峡部部分切除・卵管クリッピング)してから胚移植を行った45例(B群)であった。A群の累積妊娠率は32.7%で、1回目の胚移植で妊娠したのは13.5%、2回目21.1%、3回目26.9%、4回目32.7%であった。B群の累積妊娠率は53.3%で、1回目の胚移植で妊娠したのは37.8%、2回目46.7%、3回目48.9%、4回目53.3%であった。両群間で初回妊娠率および累積妊娠率に有意差を認めた。卵管留症に対する卵管開口術およびクリッピングは、IVF-ETの成績向上に寄与すると考えられた。

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    Other Link： https://search.jamas.or.jp/default/link?pub_year=2007&ichushi_jid=J02563&link_issn=&doc_id=20080416480001&doc_link_id=%2Fcj7sanai%2F2007%2F002301%2F001%2F0059-0066%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fcj7sanai%2F2007%2F002301%2F001%2F0059-0066%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

  • 子宮内膜症性嚢胞として経過観察中、腹腔鏡下手術により悪性腫瘍が確認された3例

    市川 剛, 長田 尚夫, 柿沼 敏行, 山本 範子, 永石 匡司, 松浦 眞彦, 山本 樹生

    エンドメトリオージス研究会会誌   28   126 - 129   2007.7

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    子宮内膜症性嚢胞は、Gn-RHアナログ療法などの普及により保存的に経過観察される場合も多く、IVF-ETなどの不妊治療を受けている症例では、嚢胞摘出術後の卵胞発育が不良であるなどの理由から摘出術を行わずに不妊治療を続行するケースが増えている。今回、不妊治療(IVF-ET)を続行中に嚢胞内に乳頭様発育あるいは充実部分が認められ、腹腔鏡下手術での術中迅速病理診断がadenocarcinomaであったため開腹手術に移行され、摘出標本検査により類内膜腺癌と診断された3例を経験したので報告した。

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  • 妊孕性温存のための多発性粘膜下子宮筋腫の術式とその予後

    山本 範子, 長田 尚夫, 市川 剛, 柿沼 敏行, 永石 匡司, 松浦 眞彦, 藤井 トム清, 山本 樹生

    産婦人科手術   ( 18 )   212 - 212   2007.6

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  • Extreme hypertrophy of the labia minora. International journal

    H Sakamoto, G Ichikawa, Y Shimizu, A Kikuchi, T Yamamoto

    Acta obstetricia et gynecologica Scandinavica   83 ( 12 )   1225 - 6   2004.12

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Misc.

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Presentations

  • Inflammatory cytokine production related to inflammasomes in decidualized human endometrial stromal cells

    Go Ichikawa, Yasuyuki Negishi, Tomoko Ichikawa, Syunji Suzuki

    Japan Society for Immunology of Reproduction  2021.10 

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    Event date： 2021.10

    Language：Japanese   Presentation type：Oral presentation (general)  

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  • Role of Type I Interferon and IRF-7 in anti-viral responses at the placenta

    Go Ichikawa

    69th Annual Congress of the Japan Society of Obstetrics and GynecologyRole of Type I Interferon and IRF!7 in anti!viral responses at the placenta  2017.4 

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    Event date： 2017.4

    Language：English   Presentation type：Symposium, workshop panel (public)  

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  • Introducing high resilience pads for trendelenburg positions

    Go Ichikawa, Shi Koren, Ayako Takizawa, Asako Nagashima, Mayu Yamada, Eika Harigane, Asako Watanabe, Yohei Tsunoda, Hiroki Shinmura, Ryuhei Kurashina, Hanako Kaseki, Masako Ichikawa, Takashi Matsushima, Shigeo Akira, Shunji Suzuki

    21st Asia-Pacific assonciation for gynecologic endoscopic surgeons  2021.9 

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    Event date： 2021.9

    Language：English   Presentation type：Oral presentation (general)  

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  • Introducing high resilience pads for trendelenburg positions

    Go Ichikawa, Shi Koren, Ayako Takizawa, Asako Nagashima, Mayu Yamada, Eika Harigane, Asako Watanabe, Yohei Tsunoda, Hiroki Shinmura, Ryuhei Kurashina, Hanako Kaseki, Masako Ichikawa, Takashi Matsushima, Shigeo Akira, Shunji Suzuki

    Japan Society of Gynecologic and Obstetric Endoscopy and Minimally Invasive Therapy  2021.9 

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    Event date： 2021.9

    Language：Japanese  

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  • Pregnancy complicated by Kikuchi desease

    Go Ichiakwa, Eri Takashima, Norio Takeda, Takasi Ashida

    Japan Society of Perinatal and Neonatal Medicine  2021.7 

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    Event date： 2021.7

    Language：Japanese   Presentation type：Oral presentation (general)  

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  • Role of type I interferon and IRF-7 in the placenta anti-viral responses

    Go ICHIKAWA

    American Society for Reproductive Immunology 36th Annual Meeting  2016.11 

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    Event date： 2016.11

    Language：English   Presentation type：Poster presentation  

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  • A CASE OF PLACENTAL POLYP TREATED WITH ILIAC ARTERY OCCLUSION AND TRANSCEVICAL RESECTION

    Go Ichikawa, Fumihisa Chishima, Takayuki Matsuno, Talmo Nakayama, Shinichi Takada, Tatsuo Yamamoto

    PLACENTA  2013.10  W B SAUNDERS CO LTD

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    Event date： 2013.10

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  • 血流豊富な胎盤ポリープに対する内腸骨動脈バルーン閉鎖を用い妊孕性を重視した治療戦略

    市川剛, 千島史尚, 松野孝幸, 高橋英幹, 高田眞一, 山本樹生, 前林俊也

    日本産科婦人科内視鏡学会雑誌  2013 

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  • Effects of anti-beta(2)-GPI antibody on normal trophoblast and choriocarcinoma cells

    Go Ichikawa, Hiromitu Azuma, Akikazu Nakamura, Mami Suzuki, Takayuki Murase, Fumihisa Chishima, Tatsuo Yamamoto

    PLACENTA  2011.9  W B SAUNDERS CO LTD

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    Event date： 2011.9

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  • P1-29-4 β2-GPIを結合させた絨毛癌細胞(BeWo)内での抗β2-GPI抗体によるシグナル伝達機構の解明(Group63 不育症2,一般演題,第63回日本産科婦人科学会学術講演会)

    市川 剛, 加藤 恵利奈, 中村 晃和, 前林 亜紀, 林 忠佑, 久野 宗一郎, 千島 史尚, 山本 樹生

    日本産科婦人科學會雜誌  2011  日本産科婦人科学会

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Research Projects

  • Analysis of innate immune lymphocytes (ILC) involved in the aggravation of influenza virus infection during pregnancy

    Grant number：16K11115  2016.4 - 2019.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    YAMAZAKI Motomi

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    Significant suppression of maternal weight was observed in pregnant mice infected with H1N1 influenza virus. Although fetal weight suppression was observed, there was no difference in the number of fetuses.
    In lung tissues of infected pregnant mice, expression of IFN-β, which plays an important role in infection protection, was increased by about 300-fold in non-pregnant mice due to H1N1 infection. On the other hand, about 3000 times increase was recognized in the pregnant mouse. In addition, infection with H1N1 increased GATA-3, which is a transcription factor for ILC-2, one of the innate immune lymphocytes, only in the lungs of pregnant mice. Only in infected pregnant mice, increased expression of Foxp3 and IL-10 was also confirmed.

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  • New strategy for the treatment of adenomyosis and endometriosis via angiotensin receptors

    Grant number：15K10734  2015.4 - 2019.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    CHISHIMA Fumihisa

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    Grant amount：\2730000 （ Direct Cost: \2100000 、 Indirect Cost：\630000 ）

    The AT1/AT2 ratio in endometriotic cysts was significantly increased compared with that in the eutopic endometrium in the proliferativephase in controls. There was a relationship between the AT1 mRNA expression and that of mPGES-1 mRNA in the endometriotic cysts. There was a significant relationship between the mRNA expression of the AT2 receptor and that of mPGES-1 in eutopic endometrium of non-endometriotic control.
    The MAS1 mRNA levels in ovarian endometriotic tissue were increased significantly regardless of the menstrual cycle phase. The MAS1 mRNA levels were significantly higher in the proliferative-tissues of the endometriosis patients than in those of the controls. The ratio of the MAS1 to the AT1 mRNA in the proliferative-tissues was increased predominantly in the endometriosis patients compared with that in the controls. Renin-angiotensinsystem may play an important role in the pathophysiology of endometriosis.

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  • Expression of vascular growth factor and hypoxia responsive factor in preeclampsia placenta

    Grant number：24592486  2012.4 - 2015.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    YAMAMOTO Tatsuo, CHISHIMA Fumihisa, KUNO Souichiro, ICHIKAWA Go

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    Grant amount：\3900000 （ Direct Cost: \3000000 、 Indirect Cost：\900000 ）

    In order to investigate pathophysiology in preeclampsia, we studied the effect of preeclampsia sera on their expression from trophoblast derived cells and the expression of PlGF, sFlt-1,MTF-1,HO-1 and HIF-1α mRNAs in placenta taken from preeclampsia. The changes of PlGF mRNA in preeclampsia placenta may relate to serum factor and the expression of MTF-1 and HIF-αmRNA. The changes of sFlt-1mRNA may relate to serum factor and the expression of HIF-alpha mRNA. We suggested that not only hypoxia but also serum factor may play a role in the levels of PlGF and sFlt-1 in preeclampsia placenta.

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